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Con el objeto de evaluar el efecto de la densidad de siembra en el alevinaje de dorada Brycon sinuensis se sembraron postlarvas (PL) de dos días de nacidas, con 8.0 mm de longitud total (LT) y 6.3 mg de peso (P), a tres densidades diferentes (50, 100 y 150 PL/m²), en nueve estanques en tierra de 50 m² en el Centro de Investigación Piscícola de la Universidad de Córdoba (CINPIC). Las PL fueron alimentadas dos veces al día con dieta comercial de 34% de proteína bruta. Se realizaron muestreos los días 0, 6, 12 y 18 para evaluar el crecimiento; con los valores promedio de LT y P se calculó la tasa de crecimiento específico (G). La productividad final se evaluó a través de la biomasa por área (BA) y el número de alevinos por área (AA). Se realizó un monitoreo diario de temperatura, oxígeno disuelto, pH y transparencia del agua de los estanques. La dureza, alcalinidad y amonio total se midieron cada cinco días. Los resultados se expresaron como promedio±desviación estándar. Las características del agua de los estanques se mantuvieron dentro del rango considerado normal para la piscicultura de especies neotropicales. Al final de los 18 días de cultivo los valores de LT y P oscilaron entre 30.3 mm y 357.5 mg (150 PL/m²) y 37.5 mm y 743.9 mg (50 PL/m²), respectivamente. La sobrevivencia osciló entre 59.9 (150 PL/m²) y 85.4% (100 PL/m²). Los valores de G oscilaron entre 25.1 (150 PL/m²) y 28.9%/día (50 PL/m²). La BA osciló entre 22.2 (50 PL/m²) y 46.0 g/m² (100 PL/m²). En ninguna de las anteriores variables se observó diferencia estadística significativa entre las densidades evaluadas (p>0.05). Los valores de AA en el alevinaje donde se sembró a 100 PL/m² (85.4 Ind/m²) y 150 PL/m² (89.8 Ind/m²) no presentaron diferencia estadistica significativa (p>0.05); pero fueron entre 2.4 y 2.6 veces el obtenido a 50 PL/m² (34.9 Ind/m²) (pThis study was conducted to investigate the effect of stocking density in the rearing of dorada (Brycon sinuensis Dahl, 1955) fingerlings. At the Fish Culture Research Center at the Córdoba University, Montería, Colombia, were stocked dorada post-larvae (PL) at 2 days after hatch, with total length to 8.0 mm (TL) and body weight to 6.3 mg (BW), in nine 50 m² earthen ponds involving three stocking densities (50, 100, 150 PL/m²). The PL were fed twice daily with artificial food of 34% crude protein. The ponds were sampled at days 0, 6, 12 and 18 to evaluate growth. It was estimated length gain, weight gain and weight-specific growth rate (G). Final yield was estimate to final biomass per area (BA) and final number of fingerlings per area (FA). Water temperature, dissolved-oxygen, pH and transparency readings were taken daily. Total hardness, alkalinity and total ammonium were measured five days each. The present study showed than water quality parameters ranged normal values to rearing neotropical fishes. The mean values of TL and BW ranged from 30.3 mm and 357.5 mg (150 PL/m²) to 37.5 mm and 743.9 mg (50 PL/m²). The survival rate ranging from 59.9 (150 PL/m²) to 85.4% (100 PL/m²). The mean G ranged from 25.1 (150 PL/ m²) to 28.9%/dia (50 PL/m²). The BA ranging from 22.2 (50 PL/m²) to 46.0 (100 PL/m²). Neither of the differences were significant (p>00.5). When PL were stocked to 100 PL/m² (85.4 Ind/m²) and 150 PL/m² (89.8 Ind/m²) the mean FA was no significant difference (p>0.05) but it was between 2.4 and 2.6 times more than when they were stocked to 50 PL/m² (34.0 Ind/m²). Based on the results from the study, is suggested that rearing of dorada fingerlings should be carried out stocking density to 150 PL/m², because the growth and survival were no different when stocked to 50 PL/m², but it is obtained higher final number of fingerlings per area.

Background: Ustekinumab is approved for ulcerative colitis (UC)., Aims: To assess the durability of ustekinumab in patients with UC and its short-term effectiveness, durability and tolerability in clinical practice., Methods: Retrospective, multicentre study of patients who had received their first ustekinumab dose at least 16 weeks before inclusion. Patients were followed until treatment discontinuation or last visit. Only patients with active disease at the start of ustekinumab treatment were considered in the effectiveness analysis. Patients who stopped ustekinumab before their last visit were considered not to be in subsequent remission., Results: We included 620 patients; 155 (25%) discontinued ustekinumab during follow-up (median 12 months). Rate of discontinuation was 20% per patient-year of follow-up. Anaemia at baseline (hazard ratio, HR 1.5; 95% confidence interval [CI] 1.1-2.1), steroids at baseline (HR 1.5; 95% CI 1.06-2.08) and more severe clinical activity at baseline (HR 1.5; 95% CI 1.09-2.06) were associated with higher risk of discontinuation. At the end of induction, 226 (40%) patients were in steroid-free clinical remission. Moderate-severe vs mild disease activity at baseline (odds ratio [OR] 0.3; 95% CI 0.2-0.5), male sex (OR 0.5; 95% CI 0.4-0.8), and increased number of previous biologics (OR 0.6; 95% CI 0.6-0.8) were associated with lower likelihood of steroid-free clinical remission at week 16. One hundred and seventy-six patients (28%) had at least one adverse event. We observed no negative impact of ustekinumab on extraintestinal manifestations and/or immune-mediated diseases., Conclusions: Ustekinumab durability in UC was relatively high, and treatment was effective in highly refractory patients. The safety profile was consistent with previous studies., (© 2024 The Author(s). Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.)

Doxycycline is a bacteriostatic antibiotic of the tetracycline group widely indicated in the treatment of numerous infections (skin, soft tissues...). Given its acid nature, doxycycline is able to potentially generate mucous damage acting as a caustic; therefore, when the capsule of doxycycline (high concentrated substance) is taken inappropriately (with a small quantity of liquid or just before laying down) and remains for a longer time in contact with the esophagus, doxycycline may cause esophagitis-type lesions and ulcerations.

Tuberculosis (TB) is a common disease in Spain, whose incidence has increased due to AIDS, immunotherapy and immigration. Intestinal disease is rare and can be difficult to diagnose because its symptoms and laboratory results are nonspecific. In addition, endoscopic lesions resemble those of other diseases such as Crohns disease (CD). Differentiating between intestinal TB and CD is very important since steroid treatment con be life saving in CD and lethal in intestinal TB. Colonoscopy plays an important role in establishing a suspected diagnosis. The endoscopic findings most characteristic of intestinal TB are circular ulcers, small diverticula (3-5 mm), and sessile firm polyps. The suspected diagnosis must be confirmed by the presence of caseating granulomas and/or acid fast bacilli. Polymerase chain reaction is currently recommended for assessing the presence of tubercle bacilli in tissue specimens obtained by endoscopic biopsy. We report a case of intestinal TB in a female renal transplant recipient that demonstrates the difficulty of making this diagnosis.

Eosinophilic gastroenteritis is rare. Fewer than 30 cases have been published in the Spanish literature, although Kaijser first described this entity in 1937. Its etiology is still unknown and it has frequently been reported to involve the stomach and small bowel, with characteristic eosinophilic infiltration of the bowel wall. The colon has rarely been reported as a site of this condition, which manifests as acute abdominal pain due to intestinal obstruction. We report the case of a 38-year-old woman who presented eosinophilic gastroenteritis. Onset was acute colitis causing acute abdomen. The patient received conservative treatment and responded well to steroids. To our knowledge, such a case has not previously been reported.