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31 results on '"Martínez, C.M."'

6. Defibrotide inhibits donor leucocyte‐endothelial interactions and protects against acute graft‐versus‐host disease

Author

García-Bernal, D., Palomo, Marta, Martínez, C.M., Millán-Rivero, J.E., García-Guillén, A.I., Blanquer, M., Díaz-Ricart, M., Sackstein, R., Carreras, Enric, Moraleda, J.M., and Universitat Autònoma de Barcelona

Subjects
0301 basic medicine, Defibrotide, medicine.medical_treatment, Biopsy, Improved survival, Graft vs Host Disease, Hematopoietic stem cell transplantation, Disease, Cell Communication, defibrotide, Mice, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Leukocytes, media_common, Cell adhesion molecule, Hematopoietic Stem Cell Transplantation, Tissue Donors, acute GvHD, Chemotaxis, Leukocyte, medicine.anatomical_structure, surgical procedures, operative, 030220 oncology & carcinogenesis, Acute Disease, Molecular Medicine, Cytokines, Original Article, Inflammation Mediators, medicine.drug, Drug, Acute GvHD, media_common.quotation_subject, T cell, Cell Line, 03 medical and health sciences, Polydeoxyribonucleotides, Acute graft versus host disease, medicine, Animals, Humans, Transplantation, Homologous, Endothelium, business.industry, Cell Biology, Original Articles, Disease Models, Animal, 030104 developmental biology, Immunology, business, Biomarkers
Abstract

Altres ajuts: This study has been funded by Josep Carreras Leukaemia Foundation (Grant 11R/2016 and 03R/2019). Allogeneic hematopoietic stem cell transplantation (allo-HCT) is an effective therapy for the treatment of high-risk haematological malignant disorders and other life-threatening haematological and genetic diseases. Acute graft-versus-host disease (aGvHD) remains the most frequent cause of non-relapse mortality following allo-HCT and limits its extensive clinical application. Current pharmacologic agents used for prophylaxis and treatment of aGvHD are not uniformly successful and have serious secondary side effects. Therefore, more effective and safe prophylaxis and therapy for aGvHD are an unmet clinical need. Defibrotide is a multi-target drug successfully employed for prophylaxis and treatment of veno-occlusive disease/sinusoidal obstruction syndrome. Recent preliminary clinical data have suggested some efficacy of defibrotide in the prevention of aGvHD after allo-HCT. Using a fully MHC-mismatched murine model of allo-HCT, we report here that defibrotide, either in prophylaxis or treatment, is effective in preventing T cell and neutrophil infiltration and aGvHD-associated tissue injury, thus reducing aGvHD incidence and severity, with significantly improved survival after allo-HCT. Moreover, we performed in vitro mechanistic studies using human cells revealing that defibrotide inhibits leucocyte-endothelial interactions by down-regulating expression of key endothelial adhesion molecules involved in leucocyte trafficking. Together, these findings provide evidence that defibrotide may represent an effective and safe clinical alternative for both prophylaxis and treatment of aGvHD after allo-HCT, paving the way for new therapeutic approaches.

Published
2020

21. Valor predictivo de los factores de riesgo propuestos para el diagnóstico de enfermería: «riesgo de caídas» en la población geriátrica institucionalizada

Author

López-López, Rocío, Lorenzo-López, Laura, García-Martínez, C.M., Maseda, Ana, Cancela Carral, Xosé María, Millán-Calenti, José Carlos, López-López, Rocío, Lorenzo-López, Laura, García-Martínez, C.M., Maseda, Ana, Cancela Carral, Xosé María, and Millán-Calenti, José Carlos

Published
2018

23. Prognostic Impact of Circulating Plasma Cells on Survival of Patients With Multiple Myeloma

Author

Granell, M., primary, Calvo, X., additional, García, A., additional, Escoda, L., additional, Martínez, C.M., additional, Teixidó, M., additional, Gimenez, M.T., additional, Sanz, P., additional, Campoy, D., additional, Vicent, A., additional, Rosiñol, L., additional, Sierra, J., additional, Bladé, J., additional, and Fernández de Larrea, C., additional

Published
2015
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30. Relative Importance of CD4+ and CD8+ T Cells in the Resolution of Chlamydophila abortus Primary Infection in Mice.

Author

Martínez, C.M., Buendía, A.J., Sánchez, J., Ortega, N., Caro, M.R., Gallego, M.C., Navarro, J.A., Cuello, F., and Salinas, J.

Subjects
IMMUNE response, CHLAMYDIACEAE, INFECTION, T cells
Abstract

Summary: The role of the specific cellular immune response is well established in Chlamydiaceae infections, but the importance of each T-cell subset seems to be species-dependent. This study was designed to clarify the role of T-cell subsets in the response to Chlamydophila abortus primary infection. C57BL/6 mice were depleted of CD4+or CD8+, or both, by monoclonal antibody injections and subsequently infected with C. abortus. Mice were killed at intervals and samples were collected for bacteriological and histopathological analysis. Also carried out were spleen cell culture, cytokine quantification, immunolabelling for C. abortus antigen, and a TUNEL assay for apoptosis. CD8+ T cell-depleted mice all died within 12 days of C. abortus infection, while no mortality was observed in the other groups; surprisingly, CD4+ T cell-depleted mice showed lower morbidity (expressed as weight loss) than did a non-depleted (control) group. CD8+ T cell-depleted mice also differed from the other groups in showing a significantly higher chlamydial burden in the liver. CD8+ T cell-depleted mice also had a higher number of apoptotic cells in hepatic inflammatory foci and showed exacerbated IFN-γ production by spleen cells after specific stimulation. Simultaneous depletion of both T-cell subpopulations led to a chronic infection, but not to early mortality. It is concluded that CD8+ T cells may play a role in the regulatory control of the CD4+ T-cell response and may have a direct cytotoxic or IFN-γ-mediated effect on infected cells. [Copyright &y& Elsevier]

Published
2006
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