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5. 216P Relationship between regulatory T lymphocytes (Treg): Related genes and pathological response to neoadjuvant docetaxel-carboplatin in early-stage triple-negative breast cancer (TNBC)

Author

Martín Lozano, R., Roche-Molina, M., Alvarez, E., Del Monte-Millan, M., Jerez Gilarranz, Y., Moreno Anton, F., García Saenz, J.Á., Echavarria Diaz-Guardamino, I., Massarrah, T., Cebollero, M., Ballesteros Garcia, A.I., Bohn Sarmiento, U., Gomez Moreno, H.L., Fuentes, H.A., Herrero Lopez, B., Gamez Casado, S., Bueno Muiño, C., Bueno, O., Lopez-Tarruella Cobo, S., and Martin Jimenez, M.

Published
2022
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10. LBA17 Adjuvant abemaciclib plus endocrine therapy for HR+, HER2-, high-risk early breast cancer: Results from a preplanned monarchE overall survival interim analysis, including 5-year efficacy outcomes

Author

Harbeck, N., Rastogi, P., O'Shaughnessy, J., Boyle, F., Cortés, J., Rugo, H.S., Goetz, M.P., Hamilton, E.P., Huang, C., Senkus-Konefka, E., Tryakin, A., Neven, P., Huober, J., Wei, R.J., Andre, V., Muñoz, M., San Antonio, B., Shahir, A., Martin Jimenez, M., and Johnston, S.R.D.

Published
2023
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11. 233P Germline genetic testing before formal counseling: Impact in cancer management in a Spanish university hospital

Author

Bringas Beranek, M., Echavarria Diaz-Guardamino, I., Polo, C., Flores Sanchez, C., Munoz Martin, A.J., Ortega Morán, L., Herrero Lopez, B., Calvo Ferrandiz, P.A., Jerez Gilarranz, Y., Torres Perez-Solero, G., Lopez-Tarruella Cobo, S., Gamez Casado, S., Perez Ramirez, S., Veiga Fernández, A., Pajares, J.A., Sanz, M., Suarez, J., Del Monte-Millan, M., Martin Jimenez, M., and Marquez-Rodas, I.

Published
2023
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12. 1654P Circulating tumor cells (CTCs) as prognostic factor for pancreatic cancer: Updated of a prospective study

Author

Gutierrez Alonso, N., Benavente, M., Bringas Beranek, M., Soto Alsar, J., Palma, M., Cañete Muñoz, M.A., Lopez Alfonso, A., Rahimi Mousavi, P., Roche-Molina, M., Del Monte-Millan, M., Megias, D., García Pérez, Á., Mullor Delgado, L.A., Ortega Morán, L., Torres Perez-Solero, G., Morón, B.I., Calvo Ferrandiz, P.A., García Alfonso, P., Martin Jimenez, M., and Munoz Martin, A.J.

Published
2023
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13. 1648P Association between circulating tumor cell count and thrombosis in pancreatic cancer

Author

Benavente, M., Gutierrez Alonso, N., Bringas Beranek, M., Soto Alsar, J., Palma, M., Cañete Muñoz, M.A., López Jiménez, C., Gutierrez Ortiz, A., Juliao Caamaño, D.S., Lopez Alfonso, A., Ortega Morán, L., Torres Perez-Solero, G., Megias, D., Calvo Ferrandiz, P.A., Del Monte-Millan, M., Rahimi Mousavi, P., Roche-Molina, M., García Alfonso, P., Martin Jimenez, M., and Munoz Martin, A.J.

Published
2023
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19. A new Iberian pleurosternid (Jurassic-Cretaceous transition, Spain) and first neuroanatomical study of this clade of stem turtles.

Author

Pérez-García, A., Martín-Jiménez, M., Aurell, M., Canudo, J.I., and Castanera, D.

Subjects
*TURTLES, *AQUATIC animals, *FRESH water, *SPECIES
Abstract

A partial skeleton of a pleurosternid turtle (Paracryptodira), from the Jurassic-Cretaceous transition at the Spanish locality of Ágreda (Moncayo Region, Soria Province), is presented here. Its partial skull represents the third of this lineage to be recognised in the European record, with the previously known specimens corresponding to British species. The specimen of Pleurosternidae studied here is attributed to a new species, Pleurosternon moncayensis. This lineage of stem turtles is identified as the most abundant and diverse group of freshwater aquatic turtles in Europe for the stages adjacent to the Jurassic-Cretaceous transition. Its presence decreased radically at post-Berriasian levels, when freshwater lineages of Eucryptodira, of Asian origin, are identified as the dominant forms at these aquatic turtle faunas. The confirmation of Pleurosternidae as freshwater inhabitants is made here, through the first neuroanatomical study for this lineage. Thus, the neuroanatomical reconstruction of Pleurosternon moncayensis sp. nov. is the first to be carried out for a freshwater stem turtle, and it allows us to identify convergent adaptations with freshwater members of the crown Testudines. [ABSTRACT FROM AUTHOR]

Published
2022
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20. 273TiP ACE-Breast-03: A phase II study patients with HER2-positive metastatic breast cancer whose disease is resistant or refractory to T-DM1, and/or T-DXd, and/or tucatinib-containing regimens treated with ARX788

Author

Hurvitz, S.A., Kalinsky, K., Tripathy, D., Sledge, G., Gradishar, W.J., O'Shaughnessy, J., Modi, S., Park, H., McCartney, A., Frentzas, S., Shannon, C., Cuff, K., Eek, R.W., Martin Jimenez, M., Curigliano, G., Jerusalem, G., Huang, C., Press, M., and Lu, J.

Published
2022
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21. 1589P Chronological pattern of venous thromboembolism (VTE) occurrence impacts in survival of pancreatic ductal adenocarcinoma (PDAC)

Author

Gonzalez Caraballo, I., Martín Lozano, R., Jiménez Rodríguez, R., Lobato Delgado, B., Cañete Muñoz, M.A., Benavente, M., Palma, M., De Toro Carmena, M.T., Morón, B.I., Tirado Anula, V.C., Soto Alsar, J., Bringas Beranek, M., Gutierrez Alonso, N., López Jiménez, C., Gutiérrez Ortiz de la Tabla, A., Juliao Caamaño, D.S., Ortega Morán, L., Soria Fernandez, J.M., Martin Jimenez, M., and Munoz Martin, A.J.

Published
2022
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22. 211MO Giredestrant (GDC-9545) vs physician choice of endocrine monotherapy (PCET) in patients (pts) with ER+, HER2– locally advanced/metastatic breast cancer (LA/mBC): Primary analysis of the phase II, randomised, open-label acelERA BC study

Author

Martin Jimenez, M., Lim, E., Chavez Mac Gregor, M., Bardia, A., Wu, J., Zhang, Q., Nowecki, Z., Cruz, F., Safin, R., Kim, S-B., Schem, C., Montero, A., Khan, S., Bandyopadhyay, R., Shivhare, M., Patre, M., Martinalbo, J., Roncoroni, L., Pérez-Moreno, P.D., and Sohn, J.

Published
2022
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23. 141MO Pathological response and early survival data according to TNBCtype4 classifier in operable triple-negative breast cancer (TNBC) treated with neoadjuvant carboplatin and docetaxel

Author

Echavarria Diaz-Guardamino, I., Lopez-Tarruella Cobo, S., Del Monte-Millan, M., Alvarez, E., Jerez, Y., Moreno Anton, F., García Saenz, J.Á., Massarrah, T., Ocaña, I., Cebollero, M., Ballesteros Garcia, A.I., Bohn Sarmiento, U., Gomez, H., Fuentes, H.A., Herrero Lopez, B., Gamez Casado, S., Bueno, O., Jiménez-Santos, M.J., Roche-Molina, M., and Martin Jimenez, M.

Published
2022
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24. LBA4 Updated overall survival (OS) results from the first-line (1L) population in the phase III MONALEESA-3 trial of postmenopausal patients (PTS) with HR+/HER2− advanced breast cancer (ABC) treated with ribociclib (RIB) + fulvestrant (FUL)

Author

Neven, P., Fasching, P.A., Chia, S., Jerusalem, G., De Laurentiis, M., Im, S.-A., Petrakova, K., Bianchi, G.V., Martin Jimenez, M., Nusch, A., Sonke, G.S., de la Cruz Merino, L., Beck, J.T., Zarate, J.P., Wang, Y., Chakravartty, A., Wang, C., and Slamon, D.

Published
2022
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26. 162O Primary analysis from DS8201-A-U105: A 2-part, open label, phase Ib trial assessing trastuzumab deruxtecan (T-DXd) with nivolumab (nivo) in patients (pts) with HER2-expressing advanced breast cancer

Author

Hamilton, E.P., Shapiro, C.L., Boni, V., Martin Jimenez, M., Del Conte, G., Cortés, J., Agrawal, L., Arkenau, H-T., Tan, A.R., Debruyne, P.R., Minchom, A.R., Rutten, A., Valdes-Albini, F., Yu, E., Suto, F., Cheng, F-C., Augustine, B., Cheng, B., Barrios, D., and Hurvitz, S.A.

Published
2022
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27. 62P Outcomes of high-risk breast cancer (BC) patients from El Álamo IV registry and GEICAM adjuvant clinical trials

Author

Martin Jimenez, M., Rodríguez-Lescure, A., Andres Conejero, R., Servitja Tormo, S., Anton Torres, A., Ruiz Borrego, M., Bermejo De Las Heras, B., Guerrero, A., Ramos Vazquez, M., Santaballa Bertran, A., Munoz, M., Batista, J.N., Lopez-Tarruella Cobo, S., Chacon Lopez-Muniz, J.I., Alvarez Lopez, I., Martinez del Prado, M.P., Miralles, J.J., Polonio, O., Jara Sanchez, C., and Mori de Santiago, M.

Published
2022
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28. 60MO Ovarian function in young patients (pts) treated with postneoadjuvant palbociclib (PAL) and endocrine therapy (ET) for hormone receptor (HR)-positive, HER2-negative early breast cancer (BC): Explorative analysis in Penelope-B

Author

Furlanetto, J., Marmé, F., Thode, C., Nekljudova, V., Liu, Y., Martin Jimenez, M., Reimer, T., Knudsen, E., Denkert, C., Bassy, M., Martin, L-A., Karn, T., Sinn, B.V., Filipitis, M., van Mackelenbergh, M., Fasching, P.A., Müller, V., Stickeler, E., Schem, C., and Loibl, S.

Published
2022
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30. 229MO Overall survival (OS) of palbociclib (P) plus endocrine therapy (ET) versus capecitabine (CAP) in hormone-receptor+/HER2- metastatic breast cancer (MBC) that progressed on aromatase inhibitors (AIs): Final results of the PEARL study

Author

Martin Jimenez, M., Zielinski, C., Ruiz-Borrego, M., Carrasco, E., Ciruelos, E.M., Muñoz, M., Bermejo, B., Margeli, M., Csoszi, T., Anton, A., Turner, N., Casas, M.I., Morales, S., Alba, E., Calvo, L., De La Haba, J., Ramos, M., Corsaro, M., Kahan, Z., and Gil-Gil, M.

Published
2021
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34. 143P Quality of life (QoL) with palbociclib (PAL) plus endocrine therapy (ET) versus (vs) capecitabine (CAP) in luminal metastatic breast cancer (MBC) patients (pts) in the PEARL study

Author

Kahan, Z., Gil-Gil, M., Ruiz-Borrego, M., Carrasco, E.M., Ciruelos, E.M., Muñoz, M., Bermejo De Las Heras, B., Margeli Vila, M., Anton, A., Casas, M., Calvo, L., de la Haba, J., Ramos, M., Álvarez-López, I., Gal-Yam, E., Gautier, E., Corsaro, M., Rodrigálvarez, G., Zielinski, C., and Martin Jimenez, M.

Published
2020
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38. Systematic study of the historical material of Upper Cretaceous reptiles from the Tremp Basin (Catalonia, Spain) housed at the Museo Nacional de Ciencias Naturales (Madrid)

Author

Ministerio de Ciencia e Innovación (España), Martín Jiménez, M., Sánchez Chillón, Begoña, Escaso, Fernando, Mocho, Pedro, Narváez, Iván, Ortega, Francisco, Pérez-García, Adán, Ministerio de Ciencia e Innovación (España), Martín Jiménez, M., Sánchez Chillón, Begoña, Escaso, Fernando, Mocho, Pedro, Narváez, Iván, Ortega, Francisco, and Pérez-García, Adán

Abstract

[Purpose]: The development of the studies on Mesozoic reptiles of the Spanish record occurred much later than in several European countries such as United Kingdom, France or Germany. Thus, very scarce and punctual findings were performed in the second half of the 19th century, followed by the work of José Royo y Gómez, which was stopped by the Spanish Civil War. The professional surveys and studies carried out in the 1950s in the Upper Cretaceous levels of the Tremp Basin (Lleida, Catalonia, Spain) can be considered as the origins of the development of this discipline in Spain. The works in the Tremp Basin were performed through the collaboration of national and foreign researchers. The Spanish palaeontologist Emiliano Aguirre and the French Albert Félix de Lapparent published some preliminary notes on the vertebrate fauna identified there. However, no detailed systematic study of these historical remains was ever done., [Methods]: The unpublished historical remains from the Tremp Basin collected by Aguirre and Lapparent, and preserved in the Museo Nacional de Ciencias Naturales (Madrid) collections, are studied here., [Results]: The analysis of unpublished historical documentation housed in the archive of that institution allows us to improve the knowledge about the history of these findings, as well as to recognize the precise sites from which each of these fossils come., [Conclusion]: The systematic study of these specimens, corresponding to turtles, crocodiles and dinosaurs, is performed here. They are attributed to Bothremydidae indet., cf. Pan-Cryptodira, cf. Allodaposuchidae, Titanosauria indet., Nodosauridae indet. and Ornithopoda indet.

Published
2017

39. Sistemas ultrasónicos para la irrigación del sistema de conductos radiculares

Author

García Delgado, A., Martín-González, J., Castellanos-Cosano, L., Martín Jiménez, M., and Segura-Egea, J.J.

Subjects
endodontics, ultrasonic irrigation, Ultrasound, CUI, Ultrasonidos, irrigación ultrasónica, PUI, endodoncia
Abstract

La eliminación de los restos de tejido pulpar vital y necrótico y de los microorganismos del sistema de conductos radiculares, es esencial para el éxito en endodoncia. La desinfección del canal radicular mediante la irrigación e instrumentación es el factor más importante en la prevención y tratamiento de la periodontitis apical. Al ser imposible con la instrumentación llegar a todas las áreas del sistema de conductos, la irrigación cobra especial importancia. Por este motivo, en la última década se han desarrollado una serie de sistemas de dispensación y agitación de irrigantes, tales como los ultrasonidos. En concreto, en este artículo de revisión se evalúa la información disponible de los diez últimos años sobre la efectividad de los sistemas ultrasónicos para eliminar bacterias, tejido pulpar, restos de dentina y barrillo dentinario, la capacidad de estos dispositivos para hacer que el irrigante penetre en el sistema de conductos radiculares y la seguridad en su uso. Los resultados de la revisión muestran que los sistemas ultrasónicos son más eficaces en el desbridamiento químico, biológico y físico del sistema de conductos radiculares que los sistemas de irrigación convencional, a la vez que son seguros. Removal of vital and necrotic remnants of pulp tissues and microorganisms from the root canal system is essential for endodontic success. Disinfection of the root canal by irrigation and instrumentation are the most important factors in the prevention and treatment of apical periodontitis. As it is impossible for the instruments to reach all the areas of the root canal system, the irrigation has gained special importance. Due to this fact, technological advances during the last decade have brought new delivery and agitation devices, such as ultrasonic devices. Particularly, this review article assesses the available information from the last ten years about the effectiveness of ultrasonic devices to remove bacteria, pulp tissue, dentin debris and smear layer, and the ability of these devices to make the irrigant solution penetrate into the root canal system and the safety of its use. Nowadays scientific literature reveals that ultrasonic devices are more effective on chemical, biological and physical debridement of the root canal system than conventional technique and being safety devices at the same time.

Published
2014

41. 323TiP - EarLEE-1: A phase 3 study of ribociclib + endocrine therapy (ET) for adjuvant treatment of patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–), high-risk, early breast cancer (EBC)

Author

Martin Jimenez, M., Bachelot, T., Barrios, C., Blackwell, K., Chia, S., De Laurentiis, M., Hurvitz, S., Janni, W., Kaufman, B., Loi, S., Schmid, P., Slamon, D., Hazell, K., Mondal, S., Shilkrut, M., Germa, C., and Hortobagyi, G.

Published
2017
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44. 186P - Breast cancer PAM50 subtypes: Correlation between RNA-Seq and multiplexed gene expression platforms

Author

Picornell, A.C., Echavarria Diaz-Guardamino, I., Alvarez Castillo, E.L., Lopez-Tarruella Cobo, S., Jerez, Y., Hoadley, K., Parker, J., del Monte-Millán, M., Ramos Medina, R., Gayarre, J., Ocaña, I., Cebollero, M., Massarrah, T., Moreno Antón, F., García-Saenz, J.A., Gomez Moreno, H., Ballesteros Garcia, A.I., Ruiz Borrego, M., Perou, C., and Martin Jimenez, M.

Published
2017
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45. 184P - Distribution of genomically defined recurrence risk in luminal A and B breast tumors defined by inmunohistochemistry: A retrospective study in Spanish population

Author

Perez Ramirez, S., del Monte-Millán, M., López-Tarruella, S., Márquez-Rodas, I., Jerez, Y., Lobo Samper, F., Izarzugaza Peron, Y., Martínez Jañez, N., García-Saenz, J.A., Moreno Antón, F., Zamora Auñón, P., Arroyo Yustos, M., Lara Álvarez, M.Á., Ciruelos Gil, E.M., Manso Sánchez, L., Echarri González, M.J., Guerra Martínez, J.A., Jara Sánchez, C., Valentín Maganto, V., and Martin Jimenez, M.

Published
2017
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46. 148O - Phase III evaluating the addition of fulvestrant (F) to anastrozol (A) as adjuvant therapy in postmenopausal women with hormone receptor positive HER2 negative (HR+/HER2-) early breast cancer (EBC): Results from the GEICAM/2006-10 study

Author

Ruiz-Borrego, M., Martin Jimenez, M., Ruiz, A., Lluch, A., Ramos, M., Cruz Jurado, J., Baena-Canada, J.M., Cirauqui, B., Rodriguez-Lescure, A., Alba Conejo, E., Martínez Jañez, N., Muñoz, M., Antolin, S., Álvarez López, I., Del Barco, S., Garcia-Estevez, L., Chacon Lopez-Muniz, J.I., Anton Torres, A., and Carrasco, E.

Published
2017
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47. 162PD - Pathological response in a triple-negative breast cancer cohort treated with neoadjuvant carboplatin and docetaxel according to Lehmann’s refined classification (TNBCtype-4)

Author

Echavarria Diaz-Guardamino, I., Picornell, A.C., López-Tarruella, S., Jerez, Y., Hoadley, K., Alvarez, E., del Monte-Millán, M., Gayarre, J., Ramos-Medina, R., Massarrah, T., Ocaña, I., Cebollero, M., Moreno Antón, F., García-Saenz, J.A., Gomez Moreno, H., Fuentes, H., Ballesteros Garcia, A.I., Bohn Sarmiento, U., Perou, C., and Martin Jimenez, M.

Published
2017
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49. Dental students' knowledge regarding the indications for antibiotics in the management of endodontic infections.

Author

Martín‐Jiménez, M., Martín‐Biedma, B., López‐López, J., Alonso‐Ezpeleta, O., Velasco‐Ortega, E., Jiménez‐Sánchez, M. C., and Segura‐Egea, J. J.

Subjects
*DENTAL students, *ANTIBIOTICS, *ENDODONTICS, *DENTAL education, *THERAPEUTICS, *CURRICULUM, INFECTION treatment
Abstract

Aim To determine the knowledge of undergraduate Spanish dental students regarding the indications of systemic antibiotics in the management of endodontic infections. Methodology The final year dental students from four Spanish dental schools were requested to answer a one-page questionnaire on the indications for systemic antibiotics in the treatment of endodontic infections. One hundred and seventy-five students were asked to participate in this research. Data were analysed using descriptive statistics and chi-square test. Results One hundred and four students (93.7%) completed satisfactorily the survey and were included in the study. The average duration of antibiotic therapy was 7.0 ± 2.0 days. All respondents chose amoxicillin as the first-choice antibiotic in patients with no medical allergies, alone (47%) or associated with clavulanic acid (53%). The first drug of choice for patients with an allergy to penicillin was clindamycin 300 mg (99%). For cases of irreversible pulpitis, up to 63% of students would prescribe antibiotics. For the scenario of a necrotic pulp, symptomatic apical periodontitis and no swelling, 44% would prescribe antibiotics. Almost 40% of students would prescribe antibiotics for necrotic pulps with asymptomatic apical periodontitis and a sinus tract. Conclusions It is necessary for the Spanish schools of dentistry to improve students' knowledge about antibiotics and their indications in endodontics. Interactive education analysing real endodontic cases using problem-based learning would help students acquire better skills in prescribing antibiotics in pulp-periapical pathosis. [ABSTRACT FROM AUTHOR]

Published
2018
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