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8. Table S2 from Therapeutic Drug Monitoring of Carboplatin in High-Dose Protocol (TI-CE) for Advanced Germ Cell Tumors: Pharmacokinetic Results of a Phase II Multicenter Study

Author

Moeung, Sotheara, primary, Chevreau, Christine, primary, Broutin, Sophie, primary, Guitton, Jérôme, primary, Lelièvre, Bénédicte, primary, Ciccolini, Joseph, primary, Massart, Christophe, primary, Fléchon, Aude, primary, Delva, Rémy, primary, Gravis, Gwenaëlle, primary, Lotz, Jean-Pierre, primary, Bay, Jacques-Olivier, primary, Gross-Goupil, Marine, primary, Paci, Angelo, primary, Marsili, Sabrina, primary, Malard, Laurence, primary, Chatelut, Etienne, primary, and Thomas, Fabienne, primary

Published
2023
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9. Figure S3 from Therapeutic Drug Monitoring of Carboplatin in High-Dose Protocol (TI-CE) for Advanced Germ Cell Tumors: Pharmacokinetic Results of a Phase II Multicenter Study

Author

Moeung, Sotheara, primary, Chevreau, Christine, primary, Broutin, Sophie, primary, Guitton, Jérôme, primary, Lelièvre, Bénédicte, primary, Ciccolini, Joseph, primary, Massart, Christophe, primary, Fléchon, Aude, primary, Delva, Rémy, primary, Gravis, Gwenaëlle, primary, Lotz, Jean-Pierre, primary, Bay, Jacques-Olivier, primary, Gross-Goupil, Marine, primary, Paci, Angelo, primary, Marsili, Sabrina, primary, Malard, Laurence, primary, Chatelut, Etienne, primary, and Thomas, Fabienne, primary

Published
2023
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10. Supplementary Data from Tipifarnib Plus Tamoxifen in Tamoxifen-Resistant Metastatic Breast Cancer: A Negative Phase II and Screening of Potential Therapeutic Markers by Proteomic Analysis

Author

Dalenc, Florence, primary, Doisneau-Sixou, Sophie F., primary, Allal, Ben C., primary, Marsili, Sabrina, primary, Lauwers-Cances, Valérie, primary, Chaoui, Karima, primary, Schiltz, Odile, primary, Monsarrat, Bernard, primary, Filleron, Thomas, primary, Renée, Nicole, primary, Malissein, Emilie, primary, Meunier, Elise, primary, Favre, Gilles, primary, and Roché, Henri, primary

Published
2023
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12. Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer

Author

Galluzzi, Lorenzo, Vitale, Ilio, Senovilla, Laura, Olaussen, Ken André, Pinna, Guillaume, Eisenberg, Tobias, Goubar, Aïcha, Martins, Isabelle, Michels, Judith, Kratassiouk, Gueorgui, Carmona-Gutierrez, Didac, Scoazec, Marie, Vacchelli, Erika, Schlemmer, Frederic, Kepp, Oliver, Shen, Shensi, Tailler, Maximilien, Niso-Santano, Mireia, Morselli, Eugenia, Criollo, Alfredo, Adjemian, Sandy, Jemaà, Mohamed, Chaba, Kariman, Pailleret, Claire, Michaud, Mickaël, Pietrocola, Federico, Tajeddine, Nicolas, de La Motte Rouge, Thibault, Araujo, Natalia, Morozova, Nadya, Robert, Thomas, Ripoche, Hugues, Commo, Frederic, Besse, Benjamin, Validire, Pierre, Fouret, Pierre, Robin, Angélique, Dorvault, Nicolas, Girard, Philippe, Gouy, Sébastien, Pautier, Patricia, Jägemann, Nora, Nickel, Ann-Christin, Marsili, Sabrina, Paccard, Caroline, Servant, Nicolas, Hupé, Philippe, Behrens, Carmen, Behnam-Motlagh, Parviz, Kohno, Kimitoshi, Cremer, Isabelle, Damotte, Diane, Alifano, Marco, Midttun, Øivind, Ueland, Per Magne, Lazar, Vladimir, Dessen, Philippe, Zischka, Hans, Chatelut, Etienne, Castedo, Maria, Madeo, Frank, Barillot, Emmanuel, Thomale, Juergen, Wistuba, Ignacio Ivan, Sautès-Fridman, Catherine, Zitvogel, Laurence, Soria, Jean-Charles, Harel-Bellan, Annick, and Kroemer, Guido

Published
2012
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15. Population pharmacokinetics of peritoneal, plasma ultrafiltrated and protein-bound oxaliplatin concentrations in patients with disseminated peritoneal cancer after intraperitoneal hyperthermic chemoperfusion of oxaliplatin following cytoreductive surgery: correlation between oxaliplatin exposure and thrombocytopenia

Author

Chalret du Rieu, Quentin, White-Koning, Mélanie, Picaud, Laetitia, Lochon, Isabelle, Marsili, Sabrina, Gladieff, Laurence, Chatelut, Etienne, and Ferron, Gwenaël

Published
2014
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21. Therapeutic Drug Monitoring of Carboplatin in High-Dose Protocol (TI-CE) for Advanced Germ Cell Tumors: Pharmacokinetic Results of a Phase II Multicenter Study

Author

Moeung, Sotheara, primary, Chevreau, Christine, additional, Broutin, Sophie, additional, Guitton, Jérôme, additional, Lelièvre, Bénédicte, additional, Ciccolini, Joseph, additional, Massart, Christophe, additional, Fléchon, Aude, additional, Delva, Rémy, additional, Gravis, Gwenaëlle, additional, Lotz, Jean-Pierre, additional, Bay, Jacques-Olivier, additional, Gross-Goupil, Marine, additional, Paci, Angelo, additional, Marsili, Sabrina, additional, Malard, Laurence, additional, Chatelut, Etienne, additional, and Thomas, Fabienne, additional

Published
2017
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23. Prognostic impact of vitamin B6 metabolism in lung cancer.

Author

UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Galluzzi, Lorenzo, Vitale, Ilio, Senovilla, Laura, Olaussen, Ken André, Pinna, Guillaume, Eisenberg, Tobias, Goubar, Aïcha, Martins, Isabelle, Michels, Judith, Kratassiouk, Gueorgui, Carmona-Gutierrez, Didac, Scoazec, Marie, Vacchelli, Erika, Schlemmer, Frederic, Kepp, Oliver, Shen, Shensi, Tailler, Maximilien, Niso-Santano, Mireia, Morselli, Eugenia, Criollo, Alfredo, Adjemian, Sandy, Jemaà, Mohamed, Chaba, Kariman, Pailleret, Claire, Michaud, Mickaël, Pietrocola, Federico, Tajeddine, Nicolas, de La Motte Rouge, Thibault, Araujo, Natalia, Morozova, Nadya, Robert, Thomas, Ripoche, Hugues, Commo, Frederic, Besse, Benjamin, Validire, Pierre, Fouret, Pierre, Robin, Angélique, Dorvault, Nicolas, Girard, Philippe, Gouy, Sébastien, Pautier, Patricia, Jägemann, Nora, Nickel, Ann-Christin, Marsili, Sabrina, Paccard, Caroline, Servant, Nicolas, Hupé, Philippe, Behrens, Carmen, Behnam-Motlagh, Parviz, Kohno, Kimitoshi, Cremer, Isabelle, Damotte, Diane, Alifano, Marco, Midttun, Oivind, Ueland, Per Magne, Lazar, Vladimir, Dessen, Philippe, Zischka, Hans, Chatelut, Etienne, Castedo, Maria, Madeo, Frank, Barillot, Emmanuel, Thomale, Juergen, Wistuba, Ignacio Ivan, Sautès-Fridman, Catherine, Zitvogel, Laurence, Soria, Jean-Charles, Harel-Bellan, Annick, Kroemer, Guido, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Galluzzi, Lorenzo, Vitale, Ilio, Senovilla, Laura, Olaussen, Ken André, Pinna, Guillaume, Eisenberg, Tobias, Goubar, Aïcha, Martins, Isabelle, Michels, Judith, Kratassiouk, Gueorgui, Carmona-Gutierrez, Didac, Scoazec, Marie, Vacchelli, Erika, Schlemmer, Frederic, Kepp, Oliver, Shen, Shensi, Tailler, Maximilien, Niso-Santano, Mireia, Morselli, Eugenia, Criollo, Alfredo, Adjemian, Sandy, Jemaà, Mohamed, Chaba, Kariman, Pailleret, Claire, Michaud, Mickaël, Pietrocola, Federico, Tajeddine, Nicolas, de La Motte Rouge, Thibault, Araujo, Natalia, Morozova, Nadya, Robert, Thomas, Ripoche, Hugues, Commo, Frederic, Besse, Benjamin, Validire, Pierre, Fouret, Pierre, Robin, Angélique, Dorvault, Nicolas, Girard, Philippe, Gouy, Sébastien, Pautier, Patricia, Jägemann, Nora, Nickel, Ann-Christin, Marsili, Sabrina, Paccard, Caroline, Servant, Nicolas, Hupé, Philippe, Behrens, Carmen, Behnam-Motlagh, Parviz, Kohno, Kimitoshi, Cremer, Isabelle, Damotte, Diane, Alifano, Marco, Midttun, Oivind, Ueland, Per Magne, Lazar, Vladimir, Dessen, Philippe, Zischka, Hans, Chatelut, Etienne, Castedo, Maria, Madeo, Frank, Barillot, Emmanuel, Thomale, Juergen, Wistuba, Ignacio Ivan, Sautès-Fridman, Catherine, Zitvogel, Laurence, Soria, Jean-Charles, Harel-Bellan, Annick, and Kroemer, Guido

Abstract

Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo. By aggravating a bioenergetic catastrophe that involves the depletion of intracellular glutathione, vitamin B6 exacerbates cisplatin-mediated DNA damage, thus sensitizing a large panel of cancer cell lines to apoptosis. Moreover, vitamin B6 sensitizes cancer cells to apoptosis induction by distinct types of physical and chemical stress, including multiple chemotherapeutics. This effect requires pyridoxal kinase (PDXK), the enzyme that generates the bioactive form of vitamin B6. In line with a general role of vitamin B6 in stress responses, low PDXK expression levels were found to be associated with poor disease outcome in two independent cohorts of patients with NSCLC. These results indicate that PDXK expression levels constitute a biomarker for risk stratification among patients with NSCLC.

Published
2012

25. Tipifarnib Plus Tamoxifen in Tamoxifen-Resistant Metastatic Breast Cancer: A Negative Phase II and Screening of Potential Therapeutic Markers by Proteomic Analysis

Author

Dalenc, Florence, primary, Doisneau-Sixou, Sophie F., additional, Allal, Ben C., additional, Marsili, Sabrina, additional, Lauwers-Cances, Valérie, additional, Chaoui, Karima, additional, Schiltz, Odile, additional, Monsarrat, Bernard, additional, Filleron, Thomas, additional, Renée, Nicole, additional, Malissein, Emilie, additional, Meunier, Elise, additional, Favre, Gilles, additional, and Roché, Henri, additional

Published
2010
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