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35 results on '"Marshall, Damian"'

3. Does political affiliation predict perception of whether certain crimes are morally permissible?

Author

Marshall, Damian and Marsh, Tim

Subjects
Political Science, FOS: Political science, Life Sciences, Psychiatry and Psychology, FOS: Law, moral permissibility, Social and Behavioral Sciences, Morality-as-Cooperation, FOS: Philosophy, ethics and religion, FOS: Psychology, Philosophy, Psychological Phenomena and Processes, moral psychology, white-collar crime, Personality and Social Contexts, Medicine and Health Sciences, Other Philosophy, Psychology, Arts and Humanities, blue-collar crime, Law, political psychology, crime
Abstract

Investigating whether Morality as Cooperation is as capable as Moral Foundations Theory at predicting political affiliation and whether that political affiliation predicts the moral permissibility of particular crimes.

Published
2022
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17. Comparability:Manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015

Author

Williams, David J., Archer, Richard, Archibald, Peter, Bantounas, Ioannis, Baptista, Ricardo, Barker, Roger, Barry, Jacqueline, Bietrix, Florence, Blair, Nicholas, Braybrook, Julian, Campbell, Jonathan, Canham, Maurice, Chandra, Amit, Foldes, Gabor, Gilmanshin, Rudy, Girard, Mathilde, Gorjup, Erwin, Hewitt, Zöe, Hourd, Paul, Hyllner, Johan, Jesson, Helen, Kee, Jasmin, Kerby, Julie, Kotsopoulou, Nina, Kowalski, Stanley, Leidel, Chris, Marshall, Damian, Masi, Louis, McCall, Mark, McCann, Conor, Medcalf, Nicholas, Moore, Harry, Ozawa, Hiroki, Pan, David, Parmar, Malin, Plant, Anne L., Reinwald, Yvonne, Sebastian, Sujith, Stacey, Glyn, Thomas, Robert J., Thomas, Dave, Thurman-Newell, Jamie, Turner, Marc, Vitillio, Loriana, Wall, Ivan, Wilson, Alison, Wolfrum, Jacqueline, Yang, Ying, and Zimmerman, Heiko

Abstract

This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to demonstrate equivalence of product after a process change; a recent publication states that this 'may be difficult for cell-based medicinal products'. Therefore a well-managed change process is required which needs access to good science and regulatory advice and developers are encouraged to seek help early. The workshop shared current thinking and best practice and allowed the definition of key research questions. The intent of this report is to summarize the key issues and the consensus reached on each of these by the expert delegates.

Published
2016

19. Writing craft

Author

Marshall, Damian M.

Subjects
Literature/writing
Abstract

I am most impressed with the variety of articles that deal with writing craft in The Writer. When I first began receiving your magazine, in my naivete I thought: What [...]

Published
2008

21. Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14–15 September 2015

Author

Williams, David J, primary, Archer, Richard, additional, Archibald, Peter, additional, Bantounas, Ioannis, additional, Baptista, Ricardo, additional, Barker, Roger, additional, Barry, Jacqueline, additional, Bietrix, Florence, additional, Blair, Nicholas, additional, Braybrook, Julian, additional, Campbell, Jonathan, additional, Canham, Maurice, additional, Chandra, Amit, additional, Foldes, Gabor, additional, Gilmanshin, Rudy, additional, Girard, Mathilde, additional, Gorjup, Erwin, additional, Hewitt, Zöe, additional, Hourd, Paul, additional, Hyllner, Johan, additional, Jesson, Helen, additional, Kee, Jasmin, additional, Kerby, Julie, additional, Kotsopoulou, Nina, additional, Kowalski, Stanley, additional, Leidel, Chris, additional, Marshall, Damian, additional, Masi, Louis, additional, McCall, Mark, additional, McCann, Conor, additional, Medcalf, Nicholas, additional, Moore, Harry, additional, Ozawa, Hiroki, additional, Pan, David, additional, Parmar, Malin, additional, Plant, Anne L, additional, Reinwald, Yvonne, additional, Sebastian, Sujith, additional, Stacey, Glyn, additional, Thomas, Robert J, additional, Thomas, Dave, additional, Thurman-Newell, Jamie, additional, Turner, Marc, additional, Vitillo, Loriana, additional, Wall, Ivan, additional, Wilson, Alison, additional, Wolfrum, Jacqueline, additional, Yang, Ying, additional, and Zimmerman, Heiko, additional

Published
2016
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22. NM-Series of Representative Manufactured Nanomaterials - Zinc Oxide NM-110, NM-111, NM-112, NM-113: Characterisation and Test Item Preparation

Author

SINGH Charanjeet, FRIEDRICHS Steffi, LEVIN Michael, BIRKEDAL Rene, JENSEN Keld Astrup, POJANA Giulio, WOHLLEBEN Wendel, SCHULTE Stefan, WIENCH Karin, TURNEY T, KOULAEVA D, MARSHALL Damian, HUND-RINKE K., KOERDEL W., VAN DOREN E, DE TEMMERMAN Pieter-Jan, ABI DAOUD FRANCISCO M, MAST Jan, GIBSON Peter, KOEBER Robert, LINSINGER Thomas, and KLEIN Christoph

Abstract

The European Commission Joint Research Centre (JRC) provides scientific support to European Union policy regarding nanotechnology. Over the last three years, the JRC, in collaboration with international public and private partners, focused part of its work on establishing and applying a priority list (NM-Series) of Representative Manufactured Nanomaterials (RMNs) in support of one of the most comprehensive nanomaterial research programmes that is currently being carried out: the Organisation for Economic Co-operation and Development’s (OECD) Working Party on Manufactured Nanomaterials (WPMN) Sponsorship Programme; this collaborative programme ultimately enables the development and collection of data on characterisation, measurement, toxicological and eco-toxicological testing, as well as risk assessment and safety evaluation of nanomaterials (NMs). It is of utmost timely importance to make representative nanomaterials available to the international scientific community, in order to enable innovation and development of safe materials and products. The present report describes the characterisation of NM-110, NM-111, NM-112, and NM-113, RMN Zinc Oxide substances, originating from defined batches of commercially manufactured material, respectively. The NM-Series materials were subsampled in collaboration with Fraunhofer Institute for Molecular and Applied Ecology (Fh IME), in order to be made available for measurement and testing for hazard identification, risk and exposure assessment studies. The results for more than 15 endpoints are addressed in the present report, including physical-chemical properties, such as size and size distribution, crystallite size and electron microscopy images. Sample and test item preparation procedures are addressed. The RMNs are studied by a number of international laboratories. The properties of the Zinc Oxide RMNs NM-110, NM-111, NM-112, and NM-113 studied and described in this report demonstrate their relevance for use in measurement and testing studies of nanomaterials. The studies were performed in close collaboration between the PROSPECT consortium partners, the JRC, the Fraunhofer Institute for Molecular and Applied Ecology (Fh-IME), BASF AG Ludwigshafen, LGC standards, the National Physical Laboratory (NPL) as national metrology institute of the United Kingdom, the National Research Centre for the Working Environment, Denmark, CSIRO and the National Measurement Institute of Australia., JRC.D-Institute for Reference Materials and Measurements (Geel)

Published
2011

24. Quantification of cells with specific phenotypes I: Determination of CD4+ cell count per microliter in reconstituted lyophilized human PBMC prelabeled with anti‐CD4 FITC antibody

Author

Stebbings, Richard, primary, Wang, Lili, additional, Sutherland, Janet, additional, Kammel, Martin, additional, Gaigalas, Adolfas K., additional, John, Manuela, additional, Roemer, Bodo, additional, Kuhne, Maren, additional, Schneider, Rudolf J., additional, Braun, Michael, additional, Engel, Andrea, additional, Dikshit, Dinesh K., additional, Abbasi, Fatima, additional, Marti, Gerald E., additional, Paola Sassi, Maria, additional, Revel, Laura, additional, Kim, Sook‐Kyung, additional, Baradez, Marc‐Olivier, additional, Lekishvili, Tamara, additional, Marshall, Damian, additional, Whitby, Liam, additional, Jing, Wang, additional, Ost, Volker, additional, Vonsky, Maxim, additional, and Neukammer, Jörg, additional

Published
2015
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25. Joined at the hip

Author

Marshall, Damian and Tomlins, Paul

Subjects
Medical screening -- Methods, Prosthesis -- Research, Biocompatibility -- Research, Implants, Artificial -- Research, Business, Chemicals, plastics and rubber industries
Abstract

Information about an in vitro approach for optimizing implant biocompatibility is presented. The screening system helps in predicting implant integration and quantifies cell attachment to several surface textures. Commercially available nickel comparator plates are used for the system.

Published
2010

34. Shining a Light on 3D Cell Culture.

Author

Watts, Sam and Marshall, Damian

Subjects
CELL culture, BIOREACTORS, CELL growth, OPTICAL detectors, CYTOLOGICAL techniques
Abstract

The article reports on the use of three-dimensional (3D) bioreactor-based methods of cell culture by researchers in response to the limitations of traditional ways of growing cells. The two major factors to consider when growing cells in culture include cell growth rate and cell viability. The article also presents a proof-of-principle study, illustrating that real-time monitoring utilizing an optical sensor can offer useful cell culture insights.

Published
2011

35. Dynamic monitoring of metal oxide nanoparticle toxicity by label free impedance sensing.

Author

Seiffert JM, Baradez MO, Nischwitz V, Lekishvili T, Goenaga-Infante H, and Marshall D

Subjects
Cell Line, Tumor, Cell Survival drug effects, Electric Impedance, Glutathione metabolism, Humans, Reactive Oxygen Species metabolism, Copper toxicity, Metal Nanoparticles toxicity, Titanium toxicity, Zinc Oxide toxicity
Abstract

The increased use of nanoparticles in industrial and medical products is driving the need for accurate, high throughput in vitro testing procedures to screen new particles for potential toxicity. While approaches using standard viability assays have been widely used, there have been increased reports of the interactions of nanoparticles with their soluble labels or optical readouts which raise concerns over the potential generation of false positive results. Here, we describe the use of an impedance spectroscopy approach to provide real-time reagent free detection of toxicity for a panel of metal oxide nanoparticles (ZnO, CuO, and TiO(2)). Using this approach, we show how impedance measurements can be used to track nanoparticle toxicity over time with comparable IC(50) values to those of standard assays (ZnO-55 μg/mL, CuO-28 μg/mL) as well as being used to identify a critical 6 h period following exposure during which the nanoparticles trigger rapid cellular responses. Through targeted analysis during this response period and the use of a novel image analysis approach, we show how the ZnO and CuO nanoparticles trigger the active export of intracellular glutathione via an increase in the activity of the ATP dependent MRP/1 efflux pumps. The loss of glutathione leads to increased production of reactive oxygen species which after 2.5 h triggers the cells to enter apoptosis resulting in a dose dependent cytotoxic response. This targeted testing strategy provides comprehensive information beyond that achieved with standard toxicity assays and indicates the potential for cell-nanoparticle interactions that could occur following in vivo exposure.

Published
2012
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