260 results on '"Marshall, Christopher B."'
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2. Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3
3. Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant
4. Regulation of GTPase function by autophosphorylation
5. Lung Cancer Driven by BRAFG469V Mutation Is Targetable by EGFR Kinase Inhibitors
6. Reconstitution and characterization of BRAF in complex with 14‐3‐3 and KRAS4B on nanodiscs
7. Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane
8. NMR in integrated biophysical drug discovery for RAS: past, present, and future
9. Hitting the hotspots
10. The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
11. Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1)
12. Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12
13. Real-Time NMR
14. Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
15. The Self‐Association of the KRAS4b Protein is Altered by Lipid‐Bilayer Composition and Electrostatics
16. Real-time NMR monitoring of biological activities in complex physiological environments
17. Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum
18. Structure and Function of the mTOR Activator Rheb
19. Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
20. Calmodulin
21. Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)
22. The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1
23. An Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis
24. Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment
25. Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts
26. Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition
27. Antifreeze Protein from Freeze-Tolerant Grass Has a Beta-Roll Fold with an Irregularly Structured Ice-Binding Site
28. Abstract 670: Distinct biochemical properties of KRAS Q61H mutant render cancer cells resistant to SHP2 inhibitors
29. Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF
30. Real-time NMR Study of Three Small GTPases Reveals That Fluorescent 2′(3′)-O-(N-Methylanthraniloyl)-tagged Nucleotides Alter Hydrolysis and Exchange Kinetics
31. Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition
32. Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53
33. Direct Visualization of Spruce Budworm Antifreeze Protein Interacting with Ice Crystals: Basal Plane Affinity Confers Hyperactivity
34. Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS
35. Regulation of GTPase function by autophosphorylation
36. Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs
37. Fluorescence Microscopy Evidence for Quasi-Permanent Attachment of Antifreeze Proteins to Ice Surfaces
38. Enhancing the activity of a beta-helical antifreeze protein by the engineered addition of coils
39. The basis for hyperactivity of antifreeze proteins
40. Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine–dependent interface: a model for KRAS oligomerization
41. Abstract A04: Biophysical and biochemical characterization of Src-phosphorylated KRas
42. Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement
43. A Non-Canonical Calmodulin Target Motif Comprising a Polybasic Region and Lipidated Terminal Residue Regulates Localization
44. Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety
45. Hyperactive Antifreeze Protein from Winter Flounder Is a Very Long Rod-like Dimer of α-Helices
46. Lung Cancer Driven by BRAFG469V Mutation Is Targetable by EGFR Kinase Inhibitors.
47. Hyperactive antifreeze protein in flounder species: The sole freeze protectant in American plaice
48. Hyperactive antifreeze protein in a fish
49. A facile method for determining ice recrystallization inhibition by antifreeze proteins
50. Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways
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