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2. Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Author

Nguyen, Phong D., primary, Gooijers, Iris, additional, Campostrini, Giulia, additional, Verkerk, Arie O., additional, Honkoop, Hessel, additional, Bouwman, Mara, additional, de Bakker, Dennis E. M., additional, Koopmans, Tim, additional, Vink, Aryan, additional, Lamers, Gerda E. M., additional, Shakked, Avraham, additional, Mars, Jonas, additional, Mulder, Aat A., additional, Chocron, Sonja, additional, Bartscherer, Kerstin, additional, Tzahor, Eldad, additional, Mummery, Christine L., additional, de Boer, Teun P., additional, Bellin, Milena, additional, and Bakkers, Jeroen, additional

Published
2023
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3. Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Author

Nguyen, Phong D, Gooijers, Iris, Campostrini, Giulia, Verkerk, Arie O, Honkoop, Hessel, Bouwman, Mara, de Bakker, Dennis E M, Koopmans, Tim, Vink, Aryan, Lamers, Gerda E M, Shakked, Avraham, Mars, Jonas, Mulder, Aat A, Chocron, Sonja, Bartscherer, Kerstin, Tzahor, Eldad, Mummery, Christine L, de Boer, Teun P, Bellin, Milena, Bakkers, Jeroen, Nguyen, Phong D, Gooijers, Iris, Campostrini, Giulia, Verkerk, Arie O, Honkoop, Hessel, Bouwman, Mara, de Bakker, Dennis E M, Koopmans, Tim, Vink, Aryan, Lamers, Gerda E M, Shakked, Avraham, Mars, Jonas, Mulder, Aat A, Chocron, Sonja, Bartscherer, Kerstin, Tzahor, Eldad, Mummery, Christine L, de Boer, Teun P, Bellin, Milena, and Bakkers, Jeroen

Abstract

Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proliferation and redifferentiation to a mature state. We found that the cardiac dyad, a structure that regulates calcium handling and excitation-contraction coupling, played a key role in the redifferentiation process. A component of the cardiac dyad called leucine-rich repeat-containing 10 (Lrrc10) acted as a negative regulator of proliferation, prevented cardiomegaly, and induced redifferentiation. We found that its function was conserved in mammalian cardiomyocytes. This study highlights the importance of the underlying mechanisms required for heart regeneration and their application to the generation of fully functional cardiomyocytes.

Published
2023

4. Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Author

Medische Fysiologie, Pathologie Pathologen staf, Circulatory Health, Child Health, Onderzoek, Cardiologie onderzoek 2, Nguyen, Phong D, Gooijers, Iris, Campostrini, Giulia, Verkerk, Arie O, Honkoop, Hessel, Bouwman, Mara, de Bakker, Dennis E M, Koopmans, Tim, Vink, Aryan, Lamers, Gerda E M, Shakked, Avraham, Mars, Jonas, Mulder, Aat A, Chocron, Sonja, Bartscherer, Kerstin, Tzahor, Eldad, Mummery, Christine L, de Boer, Teun P, Bellin, Milena, Bakkers, Jeroen, Medische Fysiologie, Pathologie Pathologen staf, Circulatory Health, Child Health, Onderzoek, Cardiologie onderzoek 2, Nguyen, Phong D, Gooijers, Iris, Campostrini, Giulia, Verkerk, Arie O, Honkoop, Hessel, Bouwman, Mara, de Bakker, Dennis E M, Koopmans, Tim, Vink, Aryan, Lamers, Gerda E M, Shakked, Avraham, Mars, Jonas, Mulder, Aat A, Chocron, Sonja, Bartscherer, Kerstin, Tzahor, Eldad, Mummery, Christine L, de Boer, Teun P, Bellin, Milena, and Bakkers, Jeroen

Published
2023

5. A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism

Author

Sub Developmental Biology, Developmental Biology, Rella, Lorenzo, Fernandes Póvoa, Euclides E, Mars, Jonas, Ebbing, Annabel L P, Schoppink, Luc, Betist, Marco C, Korswagen, Hendrik C, Sub Developmental Biology, Developmental Biology, Rella, Lorenzo, Fernandes Póvoa, Euclides E, Mars, Jonas, Ebbing, Annabel L P, Schoppink, Luc, Betist, Marco C, and Korswagen, Hendrik C

Published
2021

6. Spatial transcriptomics of the nematode Caenorhabditis elegans using RNA tomography

Author

Schild, Erik S, Mars, Jonas, Ebbing, Annabel, Vivié, Judith, Betist, Marco, Korswagen, Hendrik C, Schild, Erik S, Mars, Jonas, Ebbing, Annabel, Vivié, Judith, Betist, Marco, and Korswagen, Hendrik C

Abstract

RNA tomography or tomo-seq combines mRNA sequencing and cryo-sectioning to spatially resolve gene expression. We have adapted this method for the nematode Caenorhabditis elegans to generate anteroposterior gene expression maps at near-cellular resolution. Here, we provide a detailed overview of the method and present two approaches: one that includes RNA isolation for maximum sensitivity and one that is suitable for partial automatization and is therefore less time-consuming. For complete details on the use and execution of this protocol, please refer to Ebbing et al. (2018).

Published
2021

7. A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism

Author

Developmental Biology, Sub Developmental Biology, Rella, Lorenzo, Fernandes Póvoa, Euclides E, Mars, Jonas, Ebbing, Annabel L P, Schoppink, Luc, Betist, Marco C, Korswagen, Hendrik C, Developmental Biology, Sub Developmental Biology, Rella, Lorenzo, Fernandes Póvoa, Euclides E, Mars, Jonas, Ebbing, Annabel L P, Schoppink, Luc, Betist, Marco C, and Korswagen, Hendrik C

Published
2021

11. Spatial transcriptomics of the nematode Caenorhabditis elegansusing RNA tomography

Author

Schild, Erik S., Mars, Jonas, Ebbing, Annabel, Vivié, Judith, Betist, Marco, and Korswagen, Hendrik C.

Abstract

RNA tomography or tomo-seq combines mRNA sequencing and cryo-sectioning to spatially resolve gene expression. We have adapted this method for the nematode Caenorhabditis elegansto generate anteroposterior gene expression maps at near-cellular resolution. Here, we provide a detailed overview of the method and present two approaches: one that includes RNA isolation for maximum sensitivity and one that is suitable for partial automatization and is therefore less time-consuming.

Published
2021
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12. Low-cost, rapid and reliable DNA extraction from mammalian organoids using a C. elegans toolbox.

Author

Mars J, Darmasaputra GS, Galli M, and Korswagen HC

Abstract

High-quality DNA extraction from organoids is an important step in molecular genetics research. Here, we show that a lysis buffer from the field of Caenorhabditis elegans research, called Single Worm Lysis Buffer (SWLB), is a low-cost, yet reliable method for DNA extraction from mammalian organoids. SWLB is superior in terms of price, storage, hands-on time and sustainability compared to current standardized DNA extraction protocols, while equally effective. This work indicates that it is useful to compare methods from different model systems, such as mammalian organoids and invertebrate nematodes, to find useful alternatives for research methodologies., Competing Interests: The authors declare that there are no conflicts of interest present., (Copyright: © 2024 by the authors.)

Published
2024
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