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1. Herpes zoster after the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in actively treated cancer patients: a prospective study

Author

Nelli, Fabrizio, Fabbri, Agnese, Virtuoso, Antonella, Giannarelli, Diana, Marrucci, Eleonora, Fiore, Cristina, Giron Berrios, Julio Rodrigo, Schirripa, Marta, Signorelli, Carlo, Chilelli, Mario Giovanni, Primi, Francesca, Panichi, Valentina, Caterini, Luciano, Farinelli, Stefania, Silvestri, Maria Assunta, and Ruggeri, Enzo Maria

Published
2024
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2. Immune-related adverse events and disease outcomes after the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in cancer patients receiving immune checkpoint inhibitors

Author

Nelli, Fabrizio, Giannarelli, Diana, Fabbri, Agnese, Virtuoso, Antonella, Giron Berrios, Julio Rodrigo, Marrucci, Eleonora, Fiore, Cristina, Schirripa, Marta, Signorelli, Carlo, Chilelli, Mario Giovanni, Primi, Francesca, Panichi, Valentina, Topini, Giuseppe, Silvestri, Maria Assunta, and Ruggeri, Enzo Maria

Published
2023
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3. Dynamic changes in peripheral lymphocytes and antibody response following a third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in cancer patients

Author

Ruggeri, Enzo Maria, Nelli, Fabrizio, Giannarelli, Diana, Fabbri, Agnese, Giron Berrios, Julio Rodrigo, Virtuoso, Antonella, Marrucci, Eleonora, Mazzotta, Marco, Schirripa, Marta, Signorelli, Carlo, Chilelli, Mario Giovanni, Primi, Francesca, Fiore, Cristina, Panichi, Valentina, Topini, Giuseppe, and Silvestri, Maria Assunta

Published
2022
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5. Immune responses and clinical outcomes following the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in advanced breast cancer patients receiving targeted therapies: a prospective study

Author

Nelli, Fabrizio, primary, Fabbri, Agnese, additional, Botticelli, Andrea, additional, Giannarelli, Diana, additional, Marrucci, Eleonora, additional, Fiore, Cristina, additional, Virtuoso, Antonella, additional, Berrios, Julio Rodrigo Giron, additional, Scagnoli, Simone, additional, Pisegna, Simona, additional, Cirillo, Alessio, additional, Panichi, Valentina, additional, Massari, Annalisa, additional, Silvestri, Maria Assunta, additional, and Ruggeri, Enzo Maria, additional

Published
2023
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7. Changes in Peripheral Immune Cells after the Third Dose of SARS-CoV-2 mRNA-BNT162b2 Vaccine and Disease Outcomes in Cancer Patients Receiving Immune Checkpoint Inhibitors: A Prospective Analysis of the Vax-on-Third-Profile Study

Author

Nelli, Fabrizio, primary, Signorelli, Carlo, additional, Fabbri, Agnese, additional, Giannarelli, Diana, additional, Virtuoso, Antonella, additional, Giron Berrios, Julio Rodrigo, additional, Marrucci, Eleonora, additional, Fiore, Cristina, additional, Schirripa, Marta, additional, Chilelli, Mario Giovanni, additional, Primi, Francesca, additional, Panichi, Valentina, additional, Topini, Giuseppe, additional, Silvestri, Maria Assunta, additional, and Ruggeri, Enzo Maria, additional

Published
2023
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8. Pathologic response and survival after neoadjuvant chemotherapy with or without pertuzumab in patients with HER2-positive breast cancer: the Neopearl nationwide collaborative study

Author

Fabbri, Agnese, primary, Nelli, Fabrizio, additional, Botticelli, Andrea, additional, Giannarelli, Diana, additional, Marrucci, Eleonora, additional, Fiore, Cristina, additional, Virtuoso, Antonella, additional, Scagnoli, Simone, additional, Pisegna, Simona, additional, Alesini, Daniele, additional, Sini, Valentina, additional, Orlandi, Armando, additional, Fabi, Alessandra, additional, Piacentini, Federico, additional, Moscetti, Luca, additional, D’Auria, Giuliana, additional, Gamucci, Teresa, additional, Mazzotta, Marco, additional, Pizzuti, Laura, additional, Vici, Patrizia, additional, Cretella, Elisabetta, additional, Scavina, Paola, additional, La Cesa, Annalisa, additional, Persano, Mara, additional, Atzori, Francesco, additional, and Ruggeri, Enzo Maria, additional

Published
2023
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9. Effects of Antibody Response after Booster Vaccination on SARS-CoV-2 Breakthrough Infections and Disease Outcomes in Advanced Cancer Patients: A Prospective Analysis of the Vax-on-Third Study

Author

Nelli, Fabrizio, primary, Fabbri, Agnese, additional, Virtuoso, Antonella, additional, Giannarelli, Diana, additional, Giron Berrios, Julio Rodrigo, additional, Marrucci, Eleonora, additional, Fiore, Cristina, additional, Schirripa, Marta, additional, Signorelli, Carlo, additional, Chilelli, Mario Giovanni, additional, Primi, Francesca, additional, Pessina, Gloria, additional, Natoni, Federica, additional, Silvestri, Maria Assunta, additional, and Ruggeri, Enzo Maria, additional

Published
2023
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10. Real-Life Experience of the Prognostic Significance of the Primary Tumor Location on the Timing of Colorectal Liver Metastases: A Retrospective Analysis

Author

Signorelli, Carlo, primary, Amodio, Pietro Maria, additional, Chilelli, Mario Giovanni, additional, Santoro, Roberto, additional, Schirripa, Marta, additional, Ranalli, Teresa Valentina, additional, Pessina, Gloria, additional, Giron Berrios, Julio Rodrigo, additional, Natoni, Federica, additional, Virtuoso, Antonella, additional, Primi, Francesca, additional, Mazzotta, Marco, additional, Nelli, Fabrizio, additional, Fabbri, Agnese, additional, Marrucci, Eleonora, additional, and Ruggeri, Enzo Maria, additional

Published
2022
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11. Peripheral lymphocyte subset counts predict antibody response after SARS-CoV-2 mRNA-BNT162b2 vaccine in cancer patients: Results from the Vax-On-Profile study

Author

Nelli, Fabrizio, primary, Fabbri, Agnese, additional, Panichi, Valentina, additional, Giannarelli, Diana, additional, Topini, Giuseppe, additional, Giron Berrios, Julio R., additional, Virtuoso, Antonella, additional, Marrucci, Eleonora, additional, Mazzotta, Marco, additional, Schirripa, Marta, additional, Signorelli, Carlo, additional, Chilelli, Mario G., additional, Primi, Francesca, additional, Silvestri, Maria A., additional, and Ruggeri, Enzo M., additional

Published
2022
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12. Dynamic Changes of Peripheral NK Cells Predict Outcome in Patients with PD-L1 Positive Non-small-cell Lung Cancer Undergoing Immune Checkpoint Inhibitors as Second-line Therapy

Author

Nelli, Fabrizio, primary, Panichi, Valentina, additional, Fabbri, Agnese, additional, Natoni, Federica, additional, Giannarelli, Diana, additional, Topini, Giuseppe, additional, Virtuoso, Antonella, additional, Giron Berrios, Julio Rodrigo, additional, Marrucci, Eleonora, additional, Pessina, Gloria, additional, Silvestri, Maria Assunta, additional, and Ruggeri, Enzo Maria, additional

Published
2022
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13. Effects of the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine on immune-related adverse events and disease outcomes in cancer patients receiving immune checkpoint inhibitors

Author

Nelli, Fabrizio, primary, Giannarelli, Diana, additional, Fabbri, Agnese, additional, Virtuoso, Antonella, additional, Berrios, Julio Rodrigo Giron, additional, Marrucci, Eleonora, additional, Mazzotta, Marco, additional, Schirripa, Marta, additional, Signorelli, Carlo, additional, Chilelli, Mario Giovanni, additional, Primi, Francesca, additional, Panichi, Valentina, additional, Topini, Giuseppe, additional, Silvestri, Maria Assunta, additional, and Ruggeri, Enzo Maria, additional

Published
2022
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14. Abstract P3-11-02: Evaluation of the effects of anticancer treatments in cancer patients undergoing SARS-COV2 vaccination (VAX-on study: Breast cancer subgroup analysis)

Author

Fabbri, Agnese, primary, Marrucci, Eleonora, additional, Nelli, Fabrizio, additional, Mazzotta, Marco, additional, Onorato, Angelo, additional, Francesca, Primi, additional, Chilelli, Mario Giovanni, additional, Virtuoso, Antonella, additional, Signorelli, Carlo, additional, Berrios, Julio R Giron, additional, Schirripa, Marta, additional, Donghia, Rossella, additional, and Ruggeri, Enzo Maria, additional

Published
2022
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15. The Role of the CDK4/6 Inhibitor Ribociclib in Locally Advanced and Oligometastatic Hormone Receptor Positive, Her2 Negative, Advanced Breast Cancer: Case Series and Review of the Literature

Author

Botticelli, Andrea, primary, Fabbri, Agnese, additional, Roberto, Michela, additional, Alesini, Daniele, additional, Cirillo, Alessio, additional, D’Auria, Giuliana, additional, Krasniqi, Eriseld, additional, Marrucci, Eleonora, additional, Muratore, Margherita, additional, Pantano, Francesco, additional, Pizzuti, Laura, additional, Portarena, Ilaria, additional, Rossi, Rosalina, additional, Scagnoli, Simone, additional, and Marchetti, Paolo, additional

Published
2022
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16. Immune-related Thyroid Dysfunction (irTD) in Non-small Cell Lung Cancer (NSCLC) Correlates With Response and Survival

Author

CHILELLI, MARIO GIOVANNI, primary, SIGNORELLI, CARLO, additional, GIRON BERRIOS, JULIO RODRIGO, additional, ONORATO, ANGELO, additional, NELLI, FABRIZIO, additional, FABBRI, MARIA AGNESE, additional, PRIMI, FRANCESCA, additional, MARRUCCI, ELEONORA, additional, VIRTUOSO, ANTONELLA, additional, SCHIRRIPA, MARTA, additional, MAZZOTTA, MARCO, additional, and RUGGERI, ENZO MARIA, additional

Published
2022
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22. Ectopic salivary gland tissue in a Rathke’s cleft cyst

Author

Ranucci, Valentina, Coli, Antonella, Marrucci, Eleonora, Paolo, Mattogno Pier, Pepa, Giuseppe Della, Anile, Carmelo, and Mangiola, Annunziato

Subjects
Male, Settore MED/08 - ANATOMIA PATOLOGICA, Adolescent, Biopsy, Headache, Rathke’s cleft cyst, Case Report, Choristoma, pituitary, Magnetic Resonance Imaging, Salivary Glands, Hyperprolactinemia, Salivary gland tissue, Treatment Outcome, Predictive Value of Tests, Humans, Sella Turcica, Central Nervous System Cysts
Abstract

The presence of salivary gland tissue in the sella turcica has rarely been reported, mainly after pituitary examination at autopsy. Only five symptomatic cases have previously been described, mainly associated with Rathke's cleft cyst. We report a 17-year-old boy presenting with headaches and hyperprolactinemia. The MRI showed a 19 mm sellar mass that at surgery revealed as a cystic lesion filled with mucinous fluid. The histological examination documented the presence of ectopic salivary gland tissue in the wall of a Rathke's cleft cyst. The present report focuses on the possible pitfalls when dealing with unusual sellar lesions, and the need of increased awareness of this rare condition.

Published
2013

24. How to improve MRI accuracy in detecting deep infiltrating colorectal endometriosis: MRI findings vs. laparoscopy and histopathology

Author

Valentini, Anna Lia, Gui, Benedetta, Micco', Maura, Mingote, Maria Carla, Ninivaggi, Valeria, Guido, Maurizio, Zannoni, Gian Franco, Marrucci, Eleonora, Bonomo, Lorenzo, Valentini, Anna Lia (ORCID:0000-0001-6746-692X), Guido, Maurizio (ORCID:0000-0001-6554-0874), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Bonomo, Lorenzo (ORCID:0000-0001-5101-9367), Valentini, Anna Lia, Gui, Benedetta, Micco', Maura, Mingote, Maria Carla, Ninivaggi, Valeria, Guido, Maurizio, Zannoni, Gian Franco, Marrucci, Eleonora, Bonomo, Lorenzo, Valentini, Anna Lia (ORCID:0000-0001-6746-692X), Guido, Maurizio (ORCID:0000-0001-6554-0874), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), and Bonomo, Lorenzo (ORCID:0000-0001-5101-9367)

Abstract

Objective To verify whether the capability of magnetic resonance imaging (MRI) in diagnosing deep infiltrating colorectal endometriosis (DICE) is improved using an association of MRI findings. Methods and materials The imaging database of our Institute of Radiology was retrospectively reviewed to identify patients subjected to MRI for a suspicion of deep infiltrating endometriosis. Medical history was then investigated and only patients who were also subjected to laparoscopy (LA) were included. Absence of LA represented the exclusion criterion. Images were evaluated twice by two radiologists using two different diagnostic criteria for an abnormal result: the contemporary presence of nodules or hypointense plaque-like lesions in the adjacent fat plane and bowel wall thickness, without (first criterion) or with (second criterion) semicircular shape (i.e. ‘‘radial and retracting shape’’). Radiologists worked in consensus evaluating images in two separate sessions, using the first criterion in the first section and the second criterion in the second one. MRI results were compared with LA or histopathology as the gold standard by 2 9 2 tables and statistically analyzed (k statistics). Likelihood-ratio test was also performed, being independent from the prevalence of the disease. Results By consulting case sheets, 33/50 females (ranging age 24–39 years, mean age 32.2 years) who were subjected to MRI also underwent LA. Intestinal resection for DICE was performed in 11/33 patients; in 22/33 superficial intestinal foci, adhesions/nodules in the fat plane were simply removed. When the first criterion was applied, MRI agreement with histopathology or LA was poor (51.5 %) (k value = 0.20; p\0.055), while it was improved (96.9 %) when using the second diagnostic criterion (k value = 0.93; p\0.0000). Likelihood ratio was 1.375 (95 % CI 0.69–2.72) using the first and 22 (95 % CI 20.08–24.1) using the second criterion. Conclusion The second criterion, or the joint presence of nodul

Published
2013

25. The cytologic category of oncocytic (Hurthle) cell neoplasm mostly includes low-risk lesions at histology: an institutional experience

Author

Rossi, Esther, Martini, Maurizio, Straccia, Patrizia, Raffaelli, Marco, Pennacchia, Ilaria, Marrucci, Eleonora, Lombardi, Celestino Pio, Pontecorvi, Alfredo, Fadda, Guido, Rossi, Esther (ORCID:0000-0003-3819-4229), Martini, Maurizio (ORCID:0000-0002-6260-6310), Raffaelli, Marco (ORCID:0000-0002-1259-2491), Lombardi, Celestino Pio (ORCID:0000-0001-8910-6693), Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865), Fadda, Guido (ORCID:0000-0003-2013-7293), Rossi, Esther, Martini, Maurizio, Straccia, Patrizia, Raffaelli, Marco, Pennacchia, Ilaria, Marrucci, Eleonora, Lombardi, Celestino Pio, Pontecorvi, Alfredo, Fadda, Guido, Rossi, Esther (ORCID:0000-0003-3819-4229), Martini, Maurizio (ORCID:0000-0002-6260-6310), Raffaelli, Marco (ORCID:0000-0002-1259-2491), Lombardi, Celestino Pio (ORCID:0000-0001-8910-6693), Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865), and Fadda, Guido (ORCID:0000-0003-2013-7293)

Abstract

DESIGN: The cytological diagnosis of oncocytic/Hurthle cell neoplasms (OCN) represents a challenge with which cytopathologists face up to in their practice. The majority of these lesions undergo surgery for a definitive characterization of the nature mainly due to their more aggressive behavior than other malignant follicular lesions. In this study, we aimed at the evaluation of the effective malignant rate in a large cohort of OCNs. METHODS: From January 2008 to December 2011, we analyzed 150 cyto-histological OCNs and 64 benign oncocytic/Hurthle lesions (BOL). Both groups of patients were analyzed for clinical and cyto-histological parameters. All the nodules were sampled under sonographic guidance and processed with the liquid-based cytological method. RESULTS: In agreement with literature, we found a significant correlation only with female gender in both OCN (P=0.0160) and BOL groups. The 64 BOLs were histologically diagnosed as 15 Hashimoto thyroiditis (HT), 45 hyperplastic nodules in HT, and four papillary thyroid carcinomas (PTC, 6.2%). The 150 OCNs resulted in 141 (94%) oncocytic adenomas and nine (6%) malignant lesions. The latter group included five oncocytic carcinomas (OCC), three oncocytic variants of PTC, and one macrofollicular PTC featured by mild nuclear clearing with a dispersive cellular pattern. The malignant rate was respectively 6.2% in BOLs without any OCC whereas 3.3% OCC diagnosed in the OCN category. CONCLUSIONS: Our OCNs mostly resulted in histological adenomas with a lower rate of malignancy than in other series. Some morphological parameters (nuclear clearing, dysplasia, and dispersive cellular pattern) might be helpful in stratifying OCN patients into different risks of malignancy.

Published
2013

27. Role of SOCS3 evaluated by immunohistochemical analysis in a cohort of patients affected by prostate cancer: preliminary results

Author

Calarco, Alessandro, Pinto, Francesco, Pierconti, Francesco, Sacco, Emilio, Marrucci, Eleonora, Totaro, Angelo, Palermo, Giuseppe, Vittori, Matteo, Bassi, Pierfrancesco, Pierconti, Francesco (ORCID:0000-0003-0951-4131), Sacco, Emilio (ORCID:0000-0003-4640-8354), Bassi, Pierfrancesco (ORCID:0000-0002-4313-8427), Calarco, Alessandro, Pinto, Francesco, Pierconti, Francesco, Sacco, Emilio, Marrucci, Eleonora, Totaro, Angelo, Palermo, Giuseppe, Vittori, Matteo, Bassi, Pierfrancesco, Pierconti, Francesco (ORCID:0000-0003-0951-4131), Sacco, Emilio (ORCID:0000-0003-4640-8354), and Bassi, Pierfrancesco (ORCID:0000-0002-4313-8427)

Abstract

Chronic inflammation may play a role in prostate carcinogenesis. Molecular alterations of the Suppressor of Cytokine Signaling (SOCS)-3 can contribute to explain the pleiotropic role of interleukin (IL)-6 in this type of cancer. Recently, the methylation of SOCS3 gene has been demonstrated to cause the non-expression of the protein, being involved in the pathogenesis of prostate cancer (PC) and identifying a subset of aggressive tumors. We evaluated the expression of SOCS3 protein in patients (pt) with bioptically-diagnosed PC by immunohistochemical analysis, which is easier to perform, cheaper and more reproducible compared to DNA analysis.

Published
2012

30. Ectopic salivary gland tissue in a Rathke's cleft cyst.

Author

Ranucci V, Coli A, Marrucci E, Paolo MP, Della Pepa G, Anile C, and Mangiola A

Subjects
Adolescent, Biopsy, Central Nervous System Cysts complications, Central Nervous System Cysts surgery, Choristoma complications, Choristoma surgery, Headache etiology, Humans, Hyperprolactinemia etiology, Magnetic Resonance Imaging, Male, Predictive Value of Tests, Sella Turcica surgery, Treatment Outcome, Central Nervous System Cysts pathology, Choristoma pathology, Salivary Glands, Sella Turcica pathology
Abstract

The presence of salivary gland tissue in the sella turcica has rarely been reported, mainly after pituitary examination at autopsy. Only five symptomatic cases have previously been described, mainly associated with Rathke's cleft cyst. We report a 17-year-old boy presenting with headaches and hyperprolactinemia. The MRI showed a 19 mm sellar mass that at surgery revealed as a cystic lesion filled with mucinous fluid. The histological examination documented the presence of ectopic salivary gland tissue in the wall of a Rathke's cleft cyst. The present report focuses on the possible pitfalls when dealing with unusual sellar lesions, and the need of increased awareness of this rare condition.

Published
2013

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