1. Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil.
- Author
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Reis PG, Ayo CM, de Mattos LC, Brandão de Mattos CC, Sakita KM, de Moraes AG, Muller LP, Aquino JS, Conci Macedo L, Mazini PS, Sell AM, Marques DSO, Bestetti RB, and Visentainer JEL
- Subjects
- Adult, Aged, Aged, 80 and over, Alleles, Brazil epidemiology, Chagas Cardiomyopathy complications, Chagas Cardiomyopathy parasitology, Chagas Disease complications, Chagas Disease epidemiology, Chagas Disease parasitology, Female, Genotype, Humans, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Sex Characteristics, Trypanosoma cruzi isolation & purification, Ventricular Dysfunction, Left etiology, Ventricular Dysfunction, Left parasitology, Chagas Disease genetics, Genetic Predisposition to Disease, Interleukin-17 genetics, Polymorphism, Single Nucleotide
- Abstract
The aim of this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC). The study with 260 patients and 150 controls was conducted in the South and Southeast regions of Brazil. The genotyping was performed by PCR-RFLP. The A allele and A/A genotype of IL17A were significantly increased in patients and their subgroups (patients with CCC; patients with CCC and LVSD; and patients with CCC and severe LVSD) when compared to the control group. The analysis according to the gender showed that the A/A genotype of IL17A was more frequent in female with LVSD and mild to moderate LVSD and also in male patients with LVSD. The frequency of IL17F T/C genotype was higher in male patients with CCC and severe LVSD and in female with mild to moderate LVSD. The results suggest the possible involvement of the polymorphisms of IL17A and IL17F in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy., Competing Interests: The authors declare that there is no conflict of interests involved.
- Published
- 2017
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