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212 results on '"Marongiu, Fabio"'

1. Lung adenocarcinoma promotion by air pollutants

Author

Hill, William, Lim, Emilia L., Weeden, Clare E., Lee, Claudia, Augustine, Marcellus, Chen, Kezhong, Kuan, Feng-Che, Marongiu, Fabio, Evans, Jr, Edward J., Moore, David A., Rodrigues, Felipe S., Pich, Oriol, Bakker, Bjorn, Cha, Hongui, Myers, Renelle, van Maldegem, Febe, Boumelha, Jesse, Veeriah, Selvaraju, Rowan, Andrew, Naceur-Lombardelli, Cristina, Karasaki, Takahiro, Sivakumar, Monica, De, Swapnanil, Caswell, Deborah R., Nagano, Ai, Black, James R. M., Martínez-Ruiz, Carlos, Ryu, Min Hyung, Huff, Ryan D., Li, Shijia, Favé, Marie-Julie, Magness, Alastair, Suárez-Bonnet, Alejandro, Priestnall, Simon L., Lüchtenborg, Margreet, Lavelle, Katrina, Pethick, Joanna, Hardy, Steven, McRonald, Fiona E., Lin, Meng-Hung, Troccoli, Clara I., Ghosh, Moumita, Miller, York E., Merrick, Daniel T., Keith, Robert L., Al Bakir, Maise, Bailey, Chris, Hill, Mark S., Saal, Lao H., Chen, Yilun, George, Anthony M., Abbosh, Christopher, Kanu, Nnennaya, Lee, Se-Hoon, McGranahan, Nicholas, Berg, Christine D., Sasieni, Peter, Houlston, Richard, Turnbull, Clare, Lam, Stephen, Awadalla, Philip, Grönroos, Eva, Downward, Julian, Jacks, Tyler, Carlsten, Christopher, Malanchi, Ilaria, Hackshaw, Allan, Litchfield, Kevin, DeGregori, James, Jamal-Hanjani, Mariam, and Swanton, Charles

Published
2023
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6. The effect of environmental chemicals on the tumor microenvironment

Author

Casey, Stephanie C, Vaccari, Monica, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Barcellos-Hoff, Mary Helen, Brown, Dustin G, Chapellier, Marion, Christopher, Joseph, Curran, Colleen S, Forte, Stefano, Hamid, Roslida A, Heneberg, Petr, Koch, Daniel C, Krishnakumar, PK, Laconi, Ezio, Maguer-Satta, Veronique, Marongiu, Fabio, Memeo, Lorenzo, Mondello, Chiara, Raju, Jayadev, Roman, Jesse, Roy, Rabindra, Ryan, Elizabeth P, Ryeom, Sandra, Salem, Hosni K, Scovassi, A Ivana, Singh, Neetu, Soucek, Laura, Vermeulen, Louis, Whitfield, Jonathan R, Woodrick, Jordan, Colacci, Annamaria, Bisson, William H, and Felsher, Dean W

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Stem Cell Research, Cancer, Prevention, 2.2 Factors relating to the physical environment, Aetiology, 2.1 Biological and endogenous factors, Animals, Carcinogenesis, Environmental Exposure, Hazardous Substances, Humans, Neoplasms, Tumor Microenvironment, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects on the tumor microenvironment. In turn, the tumor microenvironment consists of a complex interaction among blood vessels that feed the tumor, the extracellular matrix that provides structural and biochemical support, signaling molecules that send messages and soluble factors such as cytokines. The tumor microenvironment also consists of many host cellular effectors including multipotent stromal cells/mesenchymal stem cells, fibroblasts, endothelial cell precursors, antigen-presenting cells, lymphocytes and innate immune cells. Carcinogens can influence the tumor microenvironment through effects on epithelial cells, the most common origin of cancer, as well as on stromal cells, extracellular matrix components and immune cells. Here, we review how environmental exposures can perturb the tumor microenvironment. We suggest a role for disrupting chemicals such as nickel chloride, Bisphenol A, butyltins, methylmercury and paraquat as well as more traditional carcinogens, such as radiation, and pharmaceuticals, such as diabetes medications, in the disruption of the tumor microenvironment. Further studies interrogating the role of chemicals and their mixtures in dose-dependent effects on the tumor microenvironment could have important general mechanistic implications for the etiology and prevention of tumorigenesis.

Published
2015

7. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Author

Goodson, William H, Lowe, Leroy, Carpenter, David O, Gilbertson, Michael, Manaf Ali, Abdul, Lopez de Cerain Salsamendi, Adela, Lasfar, Ahmed, Carnero, Amancio, Azqueta, Amaya, Amedei, Amedeo, Charles, Amelia K, Collins, Andrew R, Ward, Andrew, Salzberg, Anna C, Colacci, Annamaria, Olsen, Ann-Karin, Berg, Arthur, Barclay, Barry J, Zhou, Binhua P, Blanco-Aparicio, Carmen, Baglole, Carolyn J, Dong, Chenfang, Mondello, Chiara, Hsu, Chia-Wen, Naus, Christian C, Yedjou, Clement, Curran, Colleen S, Laird, Dale W, Koch, Daniel C, Carlin, Danielle J, Felsher, Dean W, Roy, Debasish, Brown, Dustin G, Ratovitski, Edward, Ryan, Elizabeth P, Corsini, Emanuela, Rojas, Emilio, Moon, Eun-Yi, Laconi, Ezio, Marongiu, Fabio, Al-Mulla, Fahd, Chiaradonna, Ferdinando, Darroudi, Firouz, Martin, Francis L, Van Schooten, Frederik J, Goldberg, Gary S, Wagemaker, Gerard, Nangami, Gladys N, Calaf, Gloria M, Williams, Graeme, Wolf, Gregory T, Koppen, Gudrun, Brunborg, Gunnar, Lyerly, H Kim, Krishnan, Harini, Ab Hamid, Hasiah, Yasaei, Hemad, Sone, Hideko, Kondoh, Hiroshi, Salem, Hosni K, Hsu, Hsue-Yin, Park, Hyun Ho, Koturbash, Igor, Miousse, Isabelle R, Scovassi, A Ivana, Klaunig, James E, Vondráček, Jan, Raju, Jayadev, Roman, Jesse, Wise, John Pierce, Whitfield, Jonathan R, Woodrick, Jordan, Christopher, Joseph A, Ochieng, Josiah, Martinez-Leal, Juan Fernando, Weisz, Judith, Kravchenko, Julia, Sun, Jun, Prudhomme, Kalan R, Narayanan, Kannan Badri, Cohen-Solal, Karine A, Moorwood, Kim, Gonzalez, Laetitia, Soucek, Laura, Jian, Le, D'Abronzo, Leandro S, Lin, Liang-Tzung, Li, Lin, Gulliver, Linda, McCawley, Lisa J, Memeo, Lorenzo, Vermeulen, Louis, Leyns, Luc, Zhang, Luoping, Valverde, Mahara, Khatami, Mahin, Romano, Maria Fiammetta, Chapellier, Marion, Williams, Marc A, and Wade, Mark

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, 2.2 Factors relating to the physical environment, Animals, Carcinogenesis, Carcinogens, Environmental, Environmental Exposure, Hazardous Substances, Humans, Neoplasms, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.

Published
2015

10. Dietary Microplastic Administration during Zebrafish (Danio rerio) Development: A Comprehensive and Comparative Study between Larval and Juvenile Stages.

Author

Cattaneo, Nico, Zarantoniello, Matteo, Conti, Federico, Frontini, Andrea, Chemello, Giulia, Dimichino, Beniamino, Marongiu, Fabio, Cardinaletti, Gloriana, Gioacchini, Giorgia, and Olivotto, Ike

Subjects
FISH farming, ZEBRA danio, COMPARATIVE method, BRACHYDANIO, FLUORESCENT polymers, FISH growth, OXIDATIVE stress, LARVAE, FISH larvae
Abstract

Simple Summary: Microplastics (MPs) contamination is a worldwide problem. Studies have also demonstrated their presence in fish feed, posing serious issues for the aquaculture sector. The present study investigated, for the first time through a comparative approach, the effects of different-sized fluorescent MPs included in a diet intended for zebrafish (Danio rerio). A comparison based on fish developmental stage (larval vs. juvenile), exposure time, and dietary MPs' size and concentration was performed, applying a set of laboratory analyses to elucidate MPs' possible effects on fish growth and welfare, translocation among tissues and organs, and the presence of biological barriers capable of trapping MPs. Results showed that smaller MPs and longer dietary exposure are responsible for translocation of MPs from the gut to other tissues and organs. However, the biological barriers of zebrafish are able to limit MPs' translocation to the muscle. Results obtained in this experimental model are important for possible application to other farmed finfish species. One of the main sources of MPs contamination in fish farms is aquafeed. The present study investigated, for the first time through a comparative approach, the effects of different-sized fluorescent MPs included in a diet intended for zebrafish (Danio rerio). A comparison based on fish developmental stage (larval vs. juvenile), exposure time, and dietary MPs' size and concentration was performed. Four experimental diets were formulated, starting from the control, by adding fluorescent polymer A (size range 1–5 µm) and B (size range 40–47 µm) at two different concentrations (50 and 500 mg/kg). Zebrafish were sampled at 20 (larval phase) and 60 dpf (juvenile stage). Whole larvae, intestine, liver and muscles of juveniles were collected for the analyses. Polymer A was absorbed at the intestinal level in both larvae and juveniles, while it was evidenced at the hepatic and muscular levels only in juveniles. Hepatic accumulation caused an increase in oxidative stress markers in juveniles, but at the same time significantly reduced the number of MPs able to reach the muscle, representing an efficient barrier against the spread of MPs. Polymer B simply transited through the gut, causing an abrasive effect and an increase in goblet cell abundance in both stages. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Non-Small-Cell Lung Cancer Promotion by Air Pollutants

Author

Swanton, Charles, primary, Hill, William, additional, Lim, Emilia, additional, Lee, Claudia, additional, Weeden, Clare, additional, Augustine, Marcellus, additional, Chen, Kezhong, additional, Kuan, Feng-Che, additional, Marongiu, Fabio, additional, Evans, Edward, additional, Moore, David, additional, Rodrigues, Felipe, additional, Maldegem, Febe van, additional, Boumelha, Jesse, additional, Veeriah, Selvaraju, additional, Rowan, Andrew, additional, Naceur-Lombardelli, Cristina, additional, Karasaki, Takahiro, additional, Sivakumar, Monica, additional, Caswell, Deborah, additional, Nagano, Ai, additional, Ryu, Min Hyung, additional, Huff, Ryan, additional, Li, Shijia, additional, Magness, Alastair, additional, Suarez-Bonnet, Alejandro, additional, Priestnall, Simon, additional, Lüchtenborg, Margreet, additional, Lavelle, Katrina, additional, Pethick, Joanna, additional, Hardy, Steven, additional, McRonald, Fiona, additional, Lin, Meng-Hung, additional, Troccoli, Clara, additional, Ghosh, Moumita, additional, Miller, York, additional, Merrick, Daniel, additional, Keith, Robert, additional, Bakir, Maise Al, additional, Bailey, Chris, additional, Saal, Lao, additional, Chen, Yilun, additional, George, Anthony, additional, Abbosh, Chris, additional, Kanu, Nnennaya, additional, Lee, Se-Hoon, additional, McGranahan, Nicholas, additional, Berg, Chistine, additional, Grönroos, Eva, additional, Downward, Julian, additional, Jacks, Tyler, additional, Carlsten, Christopher, additional, Malanchi, Ilaria, additional, Hackshaw, Allan, additional, Litchfield, Kevin, additional, Jamal-Hanjani, Mariam, additional, and DeGregori, James, additional

Published
2022
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29. Production of Hepatocyte-Like Cells from Human Amnion

Author

Miki, Toshio, primary, Marongiu, Fabio, additional, Ellis, Ewa C.S., additional, Dorko, Ken, additional, Mitamura, Keitaro, additional, Ranade, Aarati, additional, Gramignoli, Roberto, additional, Davila, Julio, additional, and Strom, Stephen C., additional

Published
2009
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31. Hepatic differentiation of amniotic epithelial cells

Author

Marongiu, Fabio, Gramignoli, Roberto, Dorko, Kenneth, Miki, Toshio, Ranade, Aarati R., Paola Serra, Maria, Doratiotto, Silvia, Sini, Marcella, Sharma, Shringi, Mitamura, Keitaro, Sellaro, Tiffany L., Tahan, Veysel, Skvorak, Kristen J., Ellis, Ewa C. S., Badylak, Stephen F., Davila, Julio C., Hines, Ronald, Laconi, Ezio, and Strom, Stephen C.

Published
2011
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34. Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

Author

Gensous, Noémie, primary, Ravaioli, Francesco, additional, Pirazzini, Chiara, additional, Gramignoli, Roberto, additional, Ellis, Ewa, additional, Storci, Gianluca, additional, Capri, Miriam, additional, Strom, Stephen, additional, Laconi, Ezio, additional, Franceschi, Claudio, additional, Garagnani, Paolo, additional, Marongiu, Fabio, additional, and Bacalini, Maria Giulia, additional

Published
2020
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42. Regenerative Medicine

Author

Marongiu, Fabio, primary, Serra, Maria Paola, additional, Fanti, Maura, additional, Cadoni, Erika, additional, Serra, Monica, additional, and Laconi, Ezio, additional

Published
2017
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47. The History and Use of Human Hepatocytes for the Study and Treatment of Liver Metabolic Diseases

Author

Hansel, Marc C., Gramignoli, Roberto, Skvorak, Kristen J., Dorko, Kenneth, Marongiu, Fabio, Blake, William, Davila, Julio, and Strom, Stephen C.

Subjects
Liver Diseases, Hepatocytes, Humans, Article, Liver Transplantation
Abstract

Orthotopic liver transplantation remains the only curative treatment for many end-stage liver diseases, yet the number of patients receiving liver transplants remains limited by the number of organs available for transplant. There is a need for alternative therapies for liver diseases. The transplantation of isolated hepatocytes (liver cells) has been used as an experimental therapy for liver disease in a limited number of cases. Recently, the 100th case of hepatocyte transplantation was reported. This review discusses the history of the hepatocyte transplant field, the major discoveries that supported and enabled the first hepatocyte transplants, and reviews the cases and outcomes of the first 100 clinical transplants. Some of the problems that limit the application or efficacy of hepatocyte transplantation are discussed, as are possible solutions to these problems. In conclusion, hepatocyte transplants have proven effective particularly in cases of metabolic liver disease where reversal or amelioration of the characteristic symptoms of the disease is easily quantified. However, no patients have been completely corrected of a metabolic liver disease for a significant amount of time by hepatocyte transplantation alone. It is likely that future developments in new sources of cells for transplantation will be required before this cellular therapy can be fully implemented and available for large numbers of patients.

Published
2014

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