Search

Your search keyword '"Marois, Louis"' showing total 32 results
Start Over Author "Marois, Louis"
32 results on '"Marois, Louis"'

1. Clinical and functional spectrum of RAC2-related immunodeficiency

Author

Donkó, Ágnes, Sharapova, Svetlana O., Kabat, Juraj, Ganesan, Sundar, Hauck, Fabian H., Bergerson, Jenna R. E., Marois, Louis, Abbott, Jordan, Moshous, Despina, Williams, Kelli W., Campbell, Nicholas, Martin, Paul L., Lagresle-Peyrou, Chantal, Trojan, Timothy, Kuzmenko, Natalia B., Deordieva, Ekaterina A., Raykina, Elena V., Abers, Michael S., Abolhassani, Hassan, Barlogis, Vincent, Milla, Carlos, Hall, Geoffrey, Mousallem, Talal, Church, Joseph, Kapoor, Neena, Cros, Guilhem, Chapdelaine, Hugo, Franco-Jarava, Clara, Lopez-Lerma, Ingrid, Miano, Maurizio, Leiding, Jennifer W., Klein, Christoph, Stasia, Marie José, Fischer, Alain, Hsiao, Kuang-Chih, Martelius, Timi, Sepännen, Mikko R. J., Barmettler, Sara, Walter, Jolan, Masmas, Tania N., Mukhina, Anna A., Falcone, Emilia Liana, Kracker, Sven, Shcherbina, Anna, Holland, Steven M., Leto, Thomas L., and Hsu, Amy P.

Published
2024
Full Text
View/download PDF

3. 96 Molecular and functional identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutation

Author

Borna, Simon, primary, Lee, Esmond, additional, Nideffer, Jason, additional, Ramachandran, Akshaya, additional, Wang, Bing, additional, Mavers, Melissa, additional, Narula, Mansi, additional, Garrett, Amy Kang-hee, additional, Schulze, Janika, additional, Marois, Louis, additional, Gernez, Yael, additional, Bathia, Monica, additional, Chong, Hey, additional, Walter, Jolan, additional, Kitcharoensakkul, Maleewan, additional, Lang, Abigail, additional, Cooper, Megan, additional, Bertaina, Alice, additional, Meffre, Eric, additional, Roncarolo, Maria-Grazia, additional, and Bacchetta, Rosa, additional

Published
2024
Full Text
View/download PDF

4. Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations

Author

Borna, Šimon, primary, Lee, Esmond, additional, Nideffer, Jason, additional, Ramachandran, Akshaya, additional, Wang, Bing, additional, Baker, Jeanette, additional, Mavers, Melissa, additional, Lakshmanan, Uma, additional, Narula, Mansi, additional, Garrett, Amy Kang-hee, additional, Schulze, Janika, additional, Olek, Sven, additional, Marois, Louis, additional, Gernez, Yael, additional, Bhatia, Monica, additional, Chong, Hey Jin, additional, Walter, Jolan, additional, Kitcharoensakkul, Maleewan, additional, Lang, Abigail, additional, Cooper, Megan A., additional, Bertaina, Alice, additional, Roncarolo, Maria Grazia, additional, Meffre, Eric, additional, and Bacchetta, Rosa, additional

Published
2023
Full Text
View/download PDF

6. Safety of Direct Drug Provocation for the Evaluation of Penicillin Allergy in Low-Risk Adults

Author

Brillant-Marquis, Frédéric, primary, Proulx, Émilie, additional, Ratnarajah, Kayadri, additional, Lavoie, Aubert, additional, Gauthier, Amélie, additional, Gagnon, Rémi, additional, Boursiquot, Jean-Nicolas, additional, Verreault, Nina, additional, Marois, Louis, additional, Bédard, Marc-Antoine, additional, Boivin, Martine, additional, Bédard, Pierre-Michel, additional, Ouakki, Manale, additional, De Serres, Gaston, additional, and Drolet, Jean-Philippe, additional

Published
2023
Full Text
View/download PDF

9. Analysis of novel RAC2 variants associated with neutrophil dysfunction, lymphopenia, and primary immunodeficiency

Author

Donko, Agnes P, primary, Sharapova, Svetlana O, additional, Marois, Louis, additional, Winterbourn, Christine, additional, Ashby, Louisa, additional, Martelius, Timi, additional, Seppänen, Mikko, additional, Andreae, Doerthe A., additional, Leiding, Jennifer W., additional, Gauthier, Amélie, additional, Campbell, Nicholas, additional, Ganesan, Sundar, additional, Hsiao, Kuang-Chih, additional, Holland, Steven M., additional, Falcone, Emilia L., additional, Hsu, Amy P., additional, and Leto, Thomas L., additional

Published
2023
Full Text
View/download PDF

11. Loss of FOXP3 function causes expansion of two pools of autoreactive T cells in patients with IPEX syndrome

Author

Borna, Šimon, primary, Lee, Esmond, additional, Lakshmanan, Uma, additional, Mavers, Melissa, additional, Narula, Mansi, additional, Ramachandran, Akshaya, additional, Baker, Jeanette, additional, Schulze, Janika, additional, Olek, Sven, additional, Marois, Louis, additional, Gernez, Yael, additional, Bhatia, Monica, additional, Bertaina, Alice, additional, Roncarolo, Maria Grazia, additional, Meffre, Eric, additional, and Bacchetta, Rosa, additional

Published
2022
Full Text
View/download PDF

15. Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study

Author

Yea, Carmen, primary, Bitnun, Ari, additional, Branson, Helen M, additional, Ciftci-Kavaklioglu, Beyza, additional, Rafay, Mubeen F, additional, Fortin, Olivier, additional, Moresoli, Paola, additional, Sébire, Guillaume, additional, Srour, Myriam, additional, Decaluwe, Hélène, additional, Marois, Louis, additional, Pelletier, Félixe, additional, Barton, Michelle, additional, Nouri, Maryam Nabavi, additional, Brophy, Jason, additional, Venkateswaran, Sunita, additional, Pohl, Daniela, additional, Selby, Kathryn, additional, Jones, Kevin, additional, Robinson, Joan, additional, Mineyko, Aleksandra, additional, Licht, Christoph, additional, Ertl-Wagner, Birgit, additional, and Yeh, E Ann, additional

Published
2020
Full Text
View/download PDF

16. Identification of Enterovirus at Presentation Predicts Outcomes in Acute Flaccid Myelitis A Canadian Nationwide Study in Canada

Author

Yea, Carmen, primary, Bitnun, Ari, additional, Branson, Helen M., additional, Ciftci-Kavaklioglu, Beyza, additional, Rafay, Mubeen F., additional, Fortin, Olivier, additional, Moresoli, Paola, additional, Sébire, Guillaume, additional, Srour, Myriam, additional, Decaluwe, Hélène, additional, Marois, Louis, additional, Pelletier, Félixe, additional, Barton, Michelle, additional, Nouri, Maryam Nabavi, additional, Brophy, Jason, additional, Venkateswaran, Sunita, additional, Pohl, Daniela, additional, Selby, Kathryn, additional, Jones, Kevin, additional, Robinson, Joan, additional, Mineyko, Aleksandra, additional, Licht, Christoph, additional, Ertl-Wager, Birgit, additional, and Yeh, E. Ann, additional

Published
2020
Full Text
View/download PDF

21. DOCK2 Deficiency Diagnosed 18 Years After Hematopoietic Stem Cell Transplantation.

Author

D'Astous-Gauthier, Katherine, Desjardins, Aléhandra, Marois, Louis, Falcone, Emilia Liana, and Chapdelaine, Hugo

Subjects
HEMATOPOIETIC stem cell transplantation, SEVERE combined immunodeficiency, DIAGNOSIS, GRAFT versus host disease, GUANINE nucleotide exchange factors
Abstract

Interestingly, 2 reported patients with colitis were found to have focal neutrophil infiltrates while follow-up mechanistic studies showed that DOCK2-defective neutrophils have impaired F-actin polymerization, motility, and respiratory burst [[3]]. To demonstrate that the patient's mutation does not result in stable DOCK2 protein expression, proteins were extracted from the patient's primary fibroblast culture and analyzed by immunoblotting as described in [[4]]. Keywords: DOCK2; primary immunodeficiency; Hematopoietic stem cell transplantation; combined immunodeficiency; Colitis EN DOCK2 primary immunodeficiency Hematopoietic stem cell transplantation combined immunodeficiency Colitis 1400 1402 3 07/27/21 20210801 NES 210801 Katherine D'Astous-Gauthier and Aléhandra Desjardins contributed equally to this manuscript. [Extracted from the article]

Published
2021
Full Text
View/download PDF

30. Refractory pruritus responds to dupilumab in a patient with TTC7A mutation.

Author

Alipour Tehrany Y, Marois L, Colmant C, Marchand V, Kokta V, Coulombe J, Marcoux D, Haddad E, and McCuaig C

Abstract

Competing Interests: Dr Danielle Marcoux has been primary investigator, speaker, and on advisory board for Sanofi Genzyme. Drs Yassaman Alipour Tehrany, Louis Marois, Caroline Colmant, Valérie Marchand, Victor Kokta, Jérôme Coulombe, Elie Haddad, and Catherine McCuaig have no conflicts of interest to declare.

Published
2020
Full Text
View/download PDF

31. CIN85 modulates the down-regulation of Fc gammaRIIa expression and function by c-Cbl in a PKC-dependent manner in human neutrophils.

Author

Marois L, Vaillancourt M, Paré G, Gagné V, Fernandes MJ, Rollet-Labelle E, and Naccache PH

Subjects
Adaptor Proteins, Signal Transducing metabolism, Down-Regulation genetics, Humans, Protein Stability, Protein Transport, Signal Transduction immunology, Ubiquitination, Adaptor Proteins, Signal Transducing physiology, Neutrophils metabolism, Protein Kinase C metabolism, Proto-Oncogene Proteins c-cbl physiology, Receptors, IgG biosynthesis
Abstract

We previously described a non-classical mechanism that arrests FcγRIIa signaling in human neutrophils once engaged by immune complexes or opsonized pathogens. The engagement of FcγRIIa leads to its ubiquitination by the ubiquitin ligase c-Cbl and degradation by the proteasome. Herein, we further examined some of the events regulating this novel pathway. The adaptor protein CIN85 was described in other systems to be involved in the regulation of the c-Cbl-dependent pathway. We found that CIN85 is expressed in human neutrophils and that it translocates like c-Cbl from the cytosol to the plasma membrane following receptor cross-linking. CIN85 was also recruited to the same subset of high density detergent-resistant membrane fractions in which stimulated FcγRIIa partitioned with c-Cbl. The integrity of these microdomains is essential to the FcγRIIa degradation process because the cholesterol-depleting agent methyl-β-cyclodextrin inhibits this event. Silencing the expression of CIN85 by siRNA in dibutyryl cyclic AMP-differentiated PLB 985 cells prevented FcγRIIa degradation and increased IgG-mediated phagocytosis. Confocal microscopy revealed that the presence of CIN85 is essential to the proper sorting of FcγRIIa during endocytosis. We also provide direct evidence that CIN85 is a substrate of serine/threonine kinase PKCs. Classical PKCs positively regulate FcγRIIa ubiquitination and degradation because these events were inhibited by Gö6976, a classical PKC inhibitor. We conclude that the ubiquitination and degradation of stimulated FcγRIIa mediated by c-Cbl are positively regulated by the adaptor protein CIN85 in a PKC-dependent manner and that these events contribute to the termination of FcγRIIa signaling.

Published
2011
Full Text
View/download PDF

32. Fc gammaRIIIb triggers raft-dependent calcium influx in IgG-mediated responses in human neutrophils.

Author

Marois L, Paré G, Vaillancourt M, Rollet-Labelle E, and Naccache PH

Subjects
Calcium Signaling immunology, GPI-Linked Proteins genetics, GPI-Linked Proteins physiology, Gene Expression immunology, Humans, Phagocytosis immunology, Receptors, IgG genetics, Receptors, IgG immunology, Calcium metabolism, Immunoglobulin G immunology, Membrane Microdomains immunology, Neutrophils immunology, Receptors, IgG physiology
Abstract

Human neutrophils constitutively express a unique combination of FcγRs, namely FcγRIIa and FcγRIIIb. Numerous lines of evidence support the concept that these FcγRs generate only partially characterized intracellular signals. However, despite the fact that both receptors are likely to be engaged simultaneously in a physiological setting, no recent publications have investigated the distinct, although partially convergent, results of their joint activation in IgG-dependent responses. To examine the significance of the co-expression of FcγRIIa and FcγRIIIb on human neutrophils, we analyzed the neutrophil responses to stimuli that engage these FcγRs, namely the phagocytosis of human IgG-opsonized zymosan and the responses to heat-aggregated IgGs. Blocking antibodies to either FcγR significantly decreased the phagocytic index and the stimulated production of superoxide anions. Both receptors are required for optimal IgG-dependent responses by human neutrophils. On the other hand, only blocking antibodies to FcγRIIIb, but not to FcγRIIa, inhibited the mobilization of calcium in response to heat-aggregated IgGs. Furthermore, phagocytosis of IgG-opsonized zymosan by human neutrophils required an extracellular influx of calcium that was blocked only by antibodies against FcγRIIIb. We also observed that this calcium influx as well as the IgG-dependent phagocytosis were dependent on the integrity of the plasma membrane detergent-resistant microdomains to which both isoforms were recruited following stimulation by heat-aggregated IgGs. These data clarify the mechanisms that regulate the FcγRs constitutively expressed on human neutrophils, describe a specific contribution of FcγRIIIb at the level of the mobilization of calcium, and provide evidence for a crucial role of detergent-resistant microdomains in this process.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results