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189 results on '"Marksteiner, rainer"'

1. Potency Assay Development: A Keystone for Clinical Use

Author

Torggler, Raffaela, Margreiter, Eva, Marksteiner, Rainer, Thurner, Marco, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Burns, Jorge S., editor

Published
2023
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2. Skeletal Muscle–Derived Cell Implantation for the Treatment of Fecal Incontinence: A Randomized, Placebo-Controlled Study

Author

Frudinger, Andrea, Gauruder-Burmester, Annett, Graf, Wilhelm, Lehmann, Jan-Peter, Gunnarsson, Ulf, Mihov, Minko, Ihnát, Peter, Kosorok, Pavle, Orhalmi, Julius, Slauf, Petr, Emmanuel, Anton, Hristov, Vladislav, Jungwirthova, Anna, Lehur, Paul-Antoine, Müller, Andreas, Amort, Melanie, Marksteiner, Rainer, and Thurner, Marco

Published
2023
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14. A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of [Ca.sub.v]1.4 channel activation

Author

Hemara-Wahanui, Ariana, Berjukow, Stanislav, Hope, Carolyn I., Dearden, Peter K., Wu, Shu-Biao, Wilson-Wheeler, Jane, Sharp, Dianne M., Lundon-Treweek, Patricia, Clover, Gillian M., Hoda, Jean-Charles, Striessnig, Jorg, Marksteiner, Rainer, Hering, Steffen, and Maw, Marion A.

Subjects
Mutation (Biology) -- Research, Calcium compounds -- Research, Science and technology
Abstract

Light stimuli produce graded hyperpolarizations of the photoreceptor plasma membrane and an associated decrease in a voltage-gated calcium channel conductance that mediates release of glutamate neurotransmitter. The [Ca.sub.v]1.4 channel is thought to be involved in this process. The CACNA1F gene encodes the pore-forming subunit of the [Ca.sub.v]1.4 channel and various mutations in CACNA1F cause X-linked incomplete congenital stationary night blindness (CSNB2). The molecular mechanism of the pathology underlying the CSNB2 phenotype remains to be established. Recent clinical investigations of a New Zealand family found a severe visual disorder that has some clinical similarities to, but is clearly distinct from, CSNB2. Here, we report investigations into the molecular mechanism of the pathology of this condition. Molecular genetic analyses identified a previously undescribed nucleotide substitution in CACNA1F that is predicted to encode an isoleucine to threonine substitution at CACNA1F residue 745. The I745T CACNA1F allele produced a remarkable approximately -30-mV shift in the voltage dependence of [Ca.sub.v]1.4 channel activation and significantly slower inactivation kinetics in an expression system. These findings imply that substitution of this wild-type residue in transmembrane segment IIS6 may have decreased the energy required to open the channel. Collectively, these findings suggest that a gain-of-function mechanism involving increased [Ca.sub.v]1.4 channel activity is likely to cause the unusual phenotype.

Published
2005

15. Myogenic progenitor cell transplantation for muscle regeneration following hindlimb ischemia and reperfusion

Author

Messner, Franka, primary, Thurner, Marco, additional, Müller, Jule, additional, Blumer, Michael, additional, Hofmann, Julia, additional, Marksteiner, Rainer, additional, Couillard-Despres, Sebastien, additional, Troppmair, Jakob, additional, Öfner, Dietmar, additional, Schneeberger, Stefan, additional, and Hautz, Theresa, additional

Published
2021
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16. Myogenic Progenitor Cell Transplantation for Muscle Regeneration Following Hindlimb Ischemia and Reperfusion 

Author

Messner, Franka, primary, Thurner, Marco, additional, Müller, Jule, additional, Blumer, Michael, additional, Hofmann, Julia, additional, Marksteiner, Rainer, additional, Couillard-Despres, Sebastien, additional, Troppmair, Jakob, additional, Öfner, Dietmar, additional, Schneeberger, Stefan, additional, and Hautz, Theresa, additional

Published
2020
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19. Additional file 4 of Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration

Author

Thurner, Marco, Deutsch, Martin, Janke, Katrin, Messner, Franka, Kreutzer, Christina, Beyl, Stanislav, Couillard-Després, Sébastien, Hering, Steffen, Troppmair, Jakob, and Marksteiner, Rainer

Abstract

Additional file 4: S4 Fig. Characterization of murine MPC and MPC-SMC. (A) AChE and (B) CK activity was measured by enzyme kinetics and is represented by OD412nm and OD340nm at specific time points (AChE: 60 min, CK: 10 min). Enzyme activities were compared between skeletal muscle-derived mMPC and non-myogenic cells after 6 days in skeletal muscle differentiation medium. (C) Desmin expression of mMPC visualized by immunofluorescence staining. (D) Formation of multinucleated myotubes by mMPC during differentiation in skeletal muscle differentiation medium for six days in vitro was observed. TdTomato and nuclei were stained on histological cross sections of tibialis anterior muscles of (E) control untreated mice and (F) SHO mice 70 days after intramuscular injection with TdTomato mMPC and fluorescent beads. Scale bar = 100 μm.

Published
2020
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20. Additional file 2 of Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration

Author

Thurner, Marco, Deutsch, Martin, Janke, Katrin, Messner, Franka, Kreutzer, Christina, Beyl, Stanislav, Couillard-Després, Sébastien, Hering, Steffen, Troppmair, Jakob, and Marksteiner, Rainer

Subjects
cardiovascular system, musculoskeletal system, tissues
Abstract

Additional file 2: S2 Fig. Contractile protein expression in bladder smooth muscle cells compared to MSC-SMC and MPC-SMC. Human skeletal muscle-derived MPC-SMC and MSC-SMC were compared to bladder smooth muscle-derive hBd-SMC by immunostaining for aSMA (green), SM-MHC (green), desmin (red) and vimentin (green), each combined by nuclear staining with Hoechst dye (blue). Representative images from at least three individual experiments are shown. Scale bars = 100 μm.

Published
2020
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22. Additional file 3 of Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration

Author

Thurner, Marco, Deutsch, Martin, Janke, Katrin, Messner, Franka, Kreutzer, Christina, Beyl, Stanislav, Couillard-Després, Sébastien, Hering, Steffen, Troppmair, Jakob, and Marksteiner, Rainer

Subjects
cardiovascular system, musculoskeletal system
Abstract

Additional file 3: S3 Fig. Contractility measurements in collagen gel lattices. Contractility of MPC, MSC, MPC-SMC and MSC-SMC as well as hBd-SMC was quantified by collagen gel lattice contraction. (A) Percent gel contraction from original size within 48 h of cells is shown in bar graphs. Data presented as mean ± SEM of cell preparations from each at least three individual human muscle biopsies (MSC, MPC) or three individual experiments (hBd-SMC). (B) Representative stereomicroscopic images of the collagen gels with embedded MSC, MSC and SMC each derived thereof as well as hBd-SMC in wells of a 24-well plate 48 h after gel formation.

Published
2020
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23. Additional file 1 of Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration

Author

Thurner, Marco, Deutsch, Martin, Janke, Katrin, Messner, Franka, Kreutzer, Christina, Beyl, Stanislav, Couillard-Després, Sébastien, Hering, Steffen, Troppmair, Jakob, and Marksteiner, Rainer

Abstract

Additional file 1: S1 Fig. Surface marker expression in synthetic and contractile hBd-SMC compared to MPC and MPC-SMC. Immunocytochemistry against CD146 or CD49a combined each with hematoxylin staining on MPC and SMCs cultivated in either growth medium (MPC and s-hBd-SMC) or smooth muscle differentiation medium (MPC-SMC and hBd-SMC) for 6 days. Representative images of MPC/MPC-SMC from at least two individual muscle biopsies and of two individual experiments (hBd-SMC and s-hBd-SMC). Scale bar = 100 μm.

Published
2020
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29. Stem cell therapy for SUI: a cure within reach?

Author

Strasser, Hannes, Marksteiner, Rainer, Mitterberger, Michael, Margreiter, Eva, Frauscher, Ferdinand, and Bartsch, Georg

Subjects
Urinary stress incontinence -- Care and treatment, Stem cells -- Transplantation, Stem cells -- Usage, Stem cells -- Physiological aspects, Health
Published
2008

31. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 bind to a single leucine-rich motif of Trk

Author

Windisch, Jorg M., Marksteiner, Rainer, Lang, Monika E., Auer, Bernhard, and Schneider, Rainer

Subjects
Neurons -- Growth, Leucine -- Analysis, Ligand binding (Biochemistry) -- Research, Neurotropin -- Research, Biological sciences, Chemistry
Abstract

A study used a recombinant receptor technique to establish the capacity of the various structural entities within the extracellular domain of neurotrophic receptors (TrkB) to bind the various neutrophins. Brain-derived neurotrophic factor, neurotrophin-3, and neutrophin-4 bound to the LRM3 cassette of TrkB. However, nerve growth factor did not bind. These results indicate in vivo specificities.

Published
1995

36. Three-dimensional photonic structures on transparent substrates fabricated by two-photon polymerization for use as cell substrates and for wetting experiments

Author

Heitz, Johannes, primary, Plamadeala, Cristina, additional, Wiesbauer, Moritz, additional, Freudenthaler, Peter, additional, Wollhofen, Richard, additional, Jacak, Jaroslaw, additional, Puthukodan, Sujitha, additional, Klar, Thomas A., additional, Weth, Agnes, additional, Baumgartner, Werner, additional, Magnus, Birte, additional, and Marksteiner, Rainer, additional

Published
2016
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