1,092 results on '"Marks, Michael P."'
Search Results
2. Accelerating Progress Towards the 2030 Neglected Tropical Diseases Targets: How Can Quantitative Modeling Support Programmatic Decisions?
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Borlase, Anna, Brady, Oliver, Browning, Raiha, Chitnis, Nakul, Coffeng, Luc, Crowley, Emily, Cucunubá, Zulma, Cummings, Derek, Davis, Christopher, Davis, Emma, Dixon, Matthew, Dobson, Andrew, Dyson, Louise, French, Michael, Fronterre, Claudio, Giorgi, Emanuele, Huang, Ching-I, Jain, Saurabh, James, Ananthu, Kim, Sung, Kura, Klodeta, Lucianez, Ana, Marks, Michael, Mbabazi, Pamela, Medley, Graham, Michael, Edwin, Montresor, Antonio, Mutono, Nyamai, Mwangi, Thumbi, Rock, Kat, Saboyá-Díaz, Martha-Idalí, Sasanami, Misaki, Schwehm, Markus, Spencer, Simon, Srivathsan, Ariktha, Stawski, Robert, Stolk, Wilma, Sutherland, Samuel, Tchuenté, Louis-Albert, de Vlas, Sake, Walker, Martin, Brooker, Simon, Hollingsworth, T, Solomon, Anthony, Fall, Ibrahima, Vasconcelos, Andreia, King, Jonathan, Nunes-Alves, Cláudio, Anderson, Roy, Argaw, Daniel, Basáñez, Maria-Gloria, Bilal, Shakir, Blok, David, and Blumberg, Seth
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control ,elimination ,mathematical models ,neglected tropical diseases ,policy-making ,Neglected Diseases ,Humans ,Tropical Medicine ,COVID-19 ,Models ,Theoretical ,World Health Organization ,SARS-CoV-2 ,Decision Making ,Global Health - Abstract
Over the past decade, considerable progress has been made in the control, elimination, and eradication of neglected tropical diseases (NTDs). Despite these advances, most NTD programs have recently experienced important setbacks; for example, NTD interventions were some of the most frequently and severely impacted by service disruptions due to the coronavirus disease 2019 (COVID-19) pandemic. Mathematical modeling can help inform selection of interventions to meet the targets set out in the NTD road map 2021-2030, and such studies should prioritize questions that are relevant for decision-makers, especially those designing, implementing, and evaluating national and subnational programs. In September 2022, the World Health Organization hosted a stakeholder meeting to identify such priority modeling questions across a range of NTDs and to consider how modeling could inform local decision making. Here, we summarize the outputs of the meeting, highlight common themes in the questions being asked, and discuss how quantitative modeling can support programmatic decisions that may accelerate progress towards the 2030 targets.
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- 2024
3. rVSV-ZEBOV vaccination in people with pre-existing immunity to Ebolavirus: an open-label safety and immunogenicity study in Guinean communities affected by Ebola virus disease (l’essai proches)
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Watson, Conall H., Gsell, Pierre-Stéphane, Hall, Yper, Camacho, Anton, Riveros, Ximena, Enwere, Godwin, Vicari, Andrea, Nadlaou, Séverine Danmadji, Toure, Alhassane, Sani, Ismaila M., Diallo, Abdourahamane, Kolie, Cece, Duraffour, Sophie, Ifono, Kékoura, Maomou, Andre, Dore, Kassie, Djidonou, Honora A., Bagayoko, Aminata, Damey, Philos P., Camara, Mabetty Nancy, Diallo, Fatoumata Battouly, Oumar, Fofana Thierno, Toure, Kalidou, Diaby, Mohamed Lamine, Sylla, Lansana, Conde, Doussou, Kaba, Ibrahima Lansana, Tipton, Tom, Eggo, Rosalind M., Marks, Michael, Roberts, Chrissy H., Strecker, Thomas, Günther, Stephan, Keita, Sakoba, Edmunds, W. John, Carroll, Miles W., and Henao-Restrepo, Ana Maria
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- 2024
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4. Healthcare utilisation in people with long COVID: an OpenSAFELY cohort study
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Lin, Liang-Yu, Henderson, Alasdair D., Carlile, Oliver, Dillingham, Iain, Butler-Cole, Ben F. C., Marks, Michael, Briggs, Andrew, Jit, Mark, Tomlinson, Laurie A., Bates, Chris, Parry, John, Bacon, Sebastian C. J., Goldacre, Ben, Mehrkar, Amir, MacKenna, Brian, Eggo, Rosalind M., and Herrett, Emily
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- 2024
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5. Risk factors for non-participation in ivermectin and dihydroartemisinin-piperaquine mass drug administration for malaria control in the MASSIV trial
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Kositz, Christian, Vasileva, Hristina, Mohammed, Nuredin, Achan, Jane, Dabira, Edgard Diniba, D’Alessandro, Umberto, Bradley, John, and Marks, Michael
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- 2024
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6. Accelerated immune ageing is associated with COVID-19 disease severity
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Lord, Janet M., Veenith, Tonny, Sullivan, Jack, Sharma-Oates, Archana, Richter, Alex G., Greening, Neil J., McAuley, Hamish J. C., Evans, Rachael A., Moss, Paul, Moore, Shona C., Turtle, Lance, Gautam, Nandan, Gilani, Ahmed, Bajaj, Manan, Wain, Louise V., Brightling, Christopher, Raman, Betty, Marks, Michael, Singapuri, Amisha, Elneima, Omer, Openshaw, Peter J. M., and Duggal, Niharika A.
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- 2024
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7. Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
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Liew, Felicity, Efstathiou, Claudia, Fontanella, Sara, Richardson, Matthew, Saunders, Ruth, Swieboda, Dawid, Sidhu, Jasmin K., Ascough, Stephanie, Moore, Shona C., Mohamed, Noura, Nunag, Jose, King, Clara, Leavy, Olivia C., Elneima, Omer, McAuley, Hamish J. C., Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Harris, Victoria C., Houchen-Wolloff, Linzy, Greening, Neil J., Lone, Nazir I., Thorpe, Matthew, Thompson, A. A. Roger, Rowland-Jones, Sarah L., Docherty, Annemarie B., Chalmers, James D., Ho, Ling-Pei, Horsley, Alexander, Raman, Betty, Poinasamy, Krisnah, Marks, Michael, Kon, Onn Min, Howard, Luke S., Wootton, Daniel G., Quint, Jennifer K., de Silva, Thushan I., Ho, Antonia, Chiu, Christopher, Harrison, Ewen M., Greenhalf, William, Baillie, J. Kenneth, Semple, Malcolm G., Turtle, Lance, Evans, Rachael A., Wain, Louise V., Brightling, Christopher, Thwaites, Ryan S., and Openshaw, Peter J. M.
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- 2024
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8. Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans
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Feng, Yuanqing, Xie, Ning, Inoue, Fumitaka, Fan, Shaohua, Saskin, Joshua, Zhang, Chao, Zhang, Fang, Hansen, Matthew E. B., Nyambo, Thomas, Mpoloka, Sununguko Wata, Mokone, Gaonyadiwe George, Fokunang, Charles, Belay, Gurja, Njamnshi, Alfred K., Marks, Michael S., Oancea, Elena, Ahituv, Nadav, and Tishkoff, Sarah A.
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- 2024
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9. Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features.
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Lorenzini, Ileana, Alsop, Eric, Levy, Jennifer, Gittings, Lauren M, Lall, Deepti, Rabichow, Benjamin E, Moore, Stephen, Pevey, Ryan, Bustos, Lynette M, Burciu, Camelia, Bhatia, Divya, Singer, Mo, Saul, Justin, McQuade, Amanda, Tzioras, Makis, Mota, Thomas A, Logemann, Amber, Rose, Jamie, Almeida, Sandra, Gao, Fen-Biao, Marks, Michael, Donnelly, Christopher J, Hutchins, Elizabeth, Hung, Shu-Ting, Ichida, Justin, Bowser, Robert, Spires-Jones, Tara, Blurton-Jones, Mathew, Gendron, Tania F, Baloh, Robert H, Van Keuren-Jensen, Kendall, and Sattler, Rita
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C9orf72 ,amyotrophic lateral sclerosis ,frontotemporal dementia ,iPSC-microglia ,neuroinflammation ,Aging ,Neurosciences ,Acquired Cognitive Impairment ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurodegenerative ,ALS ,Stem Cell Research - Induced Pluripotent Stem Cell - Human ,Stem Cell Research ,Brain Disorders ,Rare Diseases ,Dementia ,Frontotemporal Dementia (FTD) ,Alzheimer's Disease Related Dementias (ADRD) ,Genetics ,Stem Cell Research - Induced Pluripotent Stem Cell ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Biochemistry and Cell Biology - Abstract
While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal cells induce or exacerbate neuronal damage. We differentiated C9orf72 ALS/FTD patient-derived induced pluripotent stem cells into microglia (iPSC-MG) and examined their intrinsic phenotypes. Similar to iPSC motor neurons, C9orf72 ALS/FTD iPSC-MG mono-cultures form G4C2 repeat RNA foci, exhibit reduced C9orf72 protein levels, and generate dipeptide repeat proteins. Healthy control and C9orf72 ALS/FTD iPSC-MG equally express microglial specific genes and perform microglial functions, including inflammatory cytokine release and phagocytosis of extracellular cargos, such as synthetic amyloid beta peptides and healthy human brain synaptoneurosomes. RNA sequencing analysis revealed select transcriptional changes of genes associated with neuroinflammation or neurodegeneration in diseased microglia yet no significant differentially expressed microglial-enriched genes. Moderate molecular and functional differences were observed in C9orf72 iPSC-MG mono-cultures despite the presence of C9orf72 pathological features suggesting that a diseased microenvironment may be required to induce phenotypic changes in microglial cells and the associated neuronal dysfunction seen in C9orf72 ALS/FTD neurodegeneration.
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- 2023
10. Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
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Taquet, Maxime, Skorniewska, Zuzanna, Hampshire, Adam, Chalmers, James D., Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Raman, Betty, Leavy, Olivia C., Richardson, Matthew, Elneima, Omer, McAuley, Hamish J. C., Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M., Harris, Victoria C., Houchen-Wolloff, Linzy, Greening, Neil J., Mansoori, Parisa, Harrison, Ewen M., Docherty, Annemarie B., Lone, Nazir I., Quint, Jennifer, Sattar, Naveed, Brightling, Christopher E., Wain, Louise V., Evans, Rachael E., Geddes, John R., and Harrison, Paul J.
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- 2023
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11. Percutaneous Disc Biopsy versus Bone Biopsy for the Identification of Infectious Agents in Osteomyelitis/Discitis
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Zamarud, Aroosa, Kesten, Jamie, Park, David J., Pulli, Benjamin, Telischak, Nicholas A., Dodd, Robert L., Do, Huy M., Marks, Michael P., and Heit, Jeremy J.
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- 2024
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12. Most Promising Approaches to Improve Brain AVM Management: ARISE I Consensus Recommendations
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Samaniego, Edgar A., Dabus, Guilherme, Meyers, Philip M., Kan, Peter T., Frösen, Juhana, Lanzino, Giuseppe, Welch, Babu G., Volovici, Victor, Gonzalez, Fernando, Fifi, Johana, Charbel, Fady T., Hoh, Brian L., Khalessi, Alexander, Marks, Michael P., Berenstein, Alejandro, Pereira, Victor M., Bain, Mark, Colby, Geoffrey P., Narayanan, Sandra, Tateshima, Satoshi, Siddiqui, Adnan H., Wakhloo, Ajay K., Arthur, Adam S., and Lawton, Michael T.
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- 2024
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13. Optimizing Peer Distribution of Syphilis Self-Testing Among Men Who Have Sex with Men in China: A Multi-City Pragmatic Randomized Controlled Trial
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Wang, Yajie, Zhang, Wei, Gong, Xiao, Ong, Jason J., Marks, Michael, Zhao, Peizhen, Tucker, Joseph D., Tang, Weiming, Wu, Dan, and Wang, Cheng
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- 2023
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14. Correction: The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium
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Daynes, Enya, Baldwin, Molly, Greening, Neil J., Yates, Thomas, Bishop, Nicolette C., Mills, George, Roberts, Matthew, Hamrouni, Malik, Plekhanova, Tatiana, Vogiatzis, Ioannis, Echevarria, Carlos, Nathu, Rashmita, McAuley, Hamish J. C., Latimer, Lorna, Glennie, Jennifer, Chambers, Francesca, Penfold, Ruth, Hume, Emily, Megaritis, Dimitrios, Alexiou, Charikleia, Potthof, Sebastian, Hogg, Mitchell James, Haighton, Catherine, Nichol, Bethany, Leavy, Olivia C., Richardson, Matthew, Elneima, Omer, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M., Harris, Victoria C., Nolan, Claire M., Bolton, Charlotte, Houchen-Wolloff, Linzy, Harrison, Ewen M., Lone, Nazir, Quint, Jennifer, Chalmers, James D., Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Ramen, Betty, Wain, Louise V., Brightling, Christopher, Man, William D.-C., Evans, Rachael, and Singh, Sally J.
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- 2023
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15. The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium
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Daynes, Enya, Baldwin, Molly, Greening, Neil J., Yates, Thomas, Bishop, Nicolette C., Mills, George, Roberts, Matthew, Hamrouni, Malik, Plekhanova, Tatiana, Vogiatzis, Ioannis, Echevarria, Carlos, Nathu, Rashmita, McAuley, Hamish J. C., Latimer, Lorna, Glennie, Jennifer, Chambers, Francesca, Penfold, Ruth, Hume, Emily, Megaritis, Dimitrios, Alexiou, Charikleia, Potthoff, Sebastian, Hogg, Mitchell James, Haighton, Catherine, Nichol, Bethany, Leavy, Olivia C., Richardson, Matthew, Elneima, Omer, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M., Harris, Victoria C., Nolan, Claire M., Bolton, Charlotte, Houchen-Wolloff, Linzy, Harrison, Ewen M., Lone, Nazir, Quint, Jennifer, Chalmers, James D., Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Ramen, Betty, Wain, Louise V., Brightling, Christopher, Man, William D.-C., Evans, Rachael, and Singh, Sally J.
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- 2023
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16. Two distinct age groups of melilitites, foidites, and basanites from the southern Central European Volcanic Province reflect lithospheric heterogeneity
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Binder, Thomas, Marks, Michael A. W., Gerdes, Axel, Walter, Benjamin F., Grimmer, Jens, Beranoaguirre, Aratz, Wenzel, Thomas, and Markl, Gregor
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- 2023
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17. Chest radiograph classification and severity of suspected COVID-19 by different radiologist groups and attending clinicians: multi-reader, multi-case study
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Nair, Arjun, Procter, Alexander, Halligan, Steve, Parry, Thomas, Ahmed, Asia, Duncan, Mark, Taylor, Magali, Chouhan, Manil, Gaunt, Trevor, Roberts, James, van Vucht, Niels, Campbell, Alan, Davis, Laura May, Jacob, Joseph, Hubbard, Rachel, Kumar, Shankar, Said, Ammaarah, Chan, Xinhui, Cutfield, Tim, Luintel, Akish, Marks, Michael, Stone, Neil, and Mallet, Sue
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- 2023
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18. Contralateral Hemispheric Cerebral Blood Flow Measured With Arterial Spin Labeling Can Predict Outcome in Acute Stroke
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Thamm, Thoralf, Guo, Jia, Rosenberg, Jarrett, Liang, Tie, Marks, Michael P, Christensen, Soren, Do, Huy M, Kemp, Stephanie M, Adair, Emma, Eyngorn, Irina, Mlynash, Michael, Jovin, Tudor G, Keogh, Bart P, Chen, Hui J, Lansberg, Maarten G, Albers, Gregory W, and Zaharchuk, Greg
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Neurosciences ,Brain Disorders ,Stroke ,Biomedical Imaging ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Aged ,Brain ,Brain Ischemia ,Cerebrovascular Circulation ,Female ,Humans ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Neuroimaging ,Prospective Studies ,Treatment Outcome ,cerebrovascular circulation ,magnetic resonance imaging ,perfusion imaging ,prognosis ,prospective studies ,stroke ,Cardiorespiratory Medicine and Haematology ,Neurology & Neurosurgery ,Clinical sciences ,Allied health and rehabilitation science - Abstract
Background and Purpose- Imaging is frequently used to select acute stroke patients for intra-arterial therapy. Quantitative cerebral blood flow can be measured noninvasively with arterial spin labeling magnetic resonance imaging. Cerebral blood flow levels in the contralateral (unaffected) hemisphere may affect capacity for collateral flow and patient outcome. The goal of this study was to determine whether higher contralateral cerebral blood flow (cCBF) in acute stroke identifies patients with better 90-day functional outcome. Methods- Patients were part of the prospective, multicenter iCAS study (Imaging Collaterals in Acute Stroke) between 2013 and 2017. Consecutive patients were enrolled after being diagnosed with anterior circulation acute ischemic stroke. Inclusion criteria were ischemic anterior circulation stroke, baseline National Institutes of Health Stroke Scale score ≥1, prestroke modified Rankin Scale score ≤2, onset-to-imaging time
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- 2019
19. Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis
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Jovin, Tudor G, Nogueira, Raul G, Lansberg, Maarten G, Demchuk, Andrew M, Martins, Sheila O, Mocco, J, Ribo, Marc, Jadhav, Ashutosh P, Ortega-Gutierrez, Santiago, Hill, Michael D, Lima, Fabricio O, Haussen, Diogo C, Brown, Scott, Goyal, Mayank, Siddiqui, Adnan H, Heit, Jeremy J, Menon, Bijoy K, Kemp, Stephanie, Budzik, Ron, Urra, Xabier, Marks, Michael P, Costalat, Vincent, Liebeskind, David S, and Albers, Gregory W
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- 2022
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20. Perfusion Imaging Collateral Scores Predict Infarct Growth in Non-Reperfused DEFUSE 3 Patients
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MacLellan, Adam, Mlynash, Michael, Kemp, Stephanie, Ortega-Gutierrez, Santiago, Heit, Jeremy J., Marks, Michael P., Lansberg, Maarten G., and Albers, Gregory W.
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- 2022
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21. Transmission dynamics of SARS-CoV-2 in a strictly-Orthodox Jewish community in the UK
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Waites, William, Pearson, Carl A. B., Gaskell, Katherine M., House, Thomas, Pellis, Lorenzo, Johnson, Marina, Gould, Victoria, Hunt, Adam, Stone, Neil R. H., Kasstan, Ben, Chantler, Tracey, Lal, Sham, Roberts, Chrissy H., Goldblatt, David, Marks, Michael, and Eggo, Rosalind M.
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- 2022
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22. Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study
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Plekhanova, Tatiana, Rowlands, Alex V., Evans, Rachael A., Edwardson, Charlotte L., Bishop, Nicolette C., Bolton, Charlotte E., Chalmers, James D., Davies, Melanie J., Daynes, Enya, Dempsey, Paddy C., Docherty, Annemarie B., Elneima, Omer, Greening, Neil J., Greenwood, Sharlene A., Hall, Andrew P., Harris, Victoria C., Harrison, Ewen M., Henson, Joseph, Ho, Ling-Pei, Horsley, Alex, Houchen-Wolloff, Linzy, Khunti, Kamlesh, Leavy, Olivia C., Lone, Nazir I., Marks, Michael, Maylor, Ben, McAuley, Hamish J. C., Nolan, Claire M., Poinasamy, Krisnah, Quint, Jennifer K., Raman, Betty, Richardson, Matthew, Sargeant, Jack A., Saunders, Ruth M., Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Steiner, Michael, Stensel, David J., Wain, Louise V., Whitney, Julie, Wootton, Dan G., Brightling, Christopher E., Man, William D-C., Singh, Sally J., and Yates, Tom
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- 2022
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23. Halogens in serpentinised-troctolites from the Atlantis Massif: implications for alteration and global volatile cycling
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Kendrick, Mark A., Marks, Michael A. W., and Godard, Marguerite
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- 2022
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24. Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
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Taquet, Maxime, Skorniewska, Zuzanna, De Deyn, Thomas, Hampshire, Adam, Trender, William R, Hellyer, Peter J, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Raman, Betty, Leavy, Olivia C, Richardson, Matthew, Elneima, Omer, McAuley, Hamish J C, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M, Harris, Victoria C, Rogers, Natalie, Houchen-Wolloff, Linzy, Greening, Neil J, Mansoori, Parisa, Harrison, Ewen M, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Brightling, Christopher E, Wain, Louise V, Evans, Rachael A, Geddes, John R, Harrison, Paul J, Lone, Nazir, Baillie, Kenneth, Pairo-Castineira, Erola, Avramidis, Nikos, Wain, Louise, Guillen-Guio, Beatriz, Leavy, Olivia, Jones, S, Armstrong, Lisa, Hairsine, Brigid, Henson, Helen, Kurasz, Claire, Shaw, Alison, Shenton, Liz, Dobson, Hannah, Dell, Amanda, Fairbairn, Sara, Hawkings, Nancy, Haworth, Jill, Hoare, Michaela, Lewis, Victoria, Lucey, Alice, Mallison, Georgia, Nassa, Heeah, Pennington, Chris, Price, Andrea, Price, Claire, Storrie, Andrew, Willis, Gemma, Young, Susan, Poinasamy, Krisnah, Walker, Samantha, Jarrold, Ian, Rawlik, Konrad, Sanderson, Amy, Chong-James, K, David, C, James, W Y, Pfeffer, Paul, Zongo, O, Martineau, Adrian, Manisty, C, Armour, Cherie, Brown, Vanessa, Busby, John, Connolly, Bronwen, Craig, Thelma, Drain, Stephen, Heaney, Liam, King, Bernie, Magee, Nick, Major, E, McAulay, Danny, McGarvey, Lorcan, McGinness, Jade, Peto, Tunde, Stone, Roisin, Bolger, Annette, Davies, Ffyon, Haggar, Ahmed, Lewis, Joanne, Lloyd, Arwel, Manley, R, McIvor, Emma, Menzies, Daniel, Roberts, K, Saxon, W, Southern, David, Subbe, Christian, Whitehead, Victoria, Bularga, Anda, Mills, Nicholas, Dawson, Joy, El-Taweel, Hosni, Robinson, Leanne, Brear, Lucy, Regan, Karen, Saralaya, Dinesh, Storton, Kim, Amoils, Shannon, Bermperi, Areti, Cruz, Isabel, Dempsey, K, Elmer, Anne, Fuld, Jonathon, Jones, H, Jose, Sherly, Marciniak, Stefan, Parkes, M, Ribeiro, Carla, Taylor, Jessica, Toshner, Mark, Watson, L, Worsley, J, Broad, Lauren, Evans, Teriann, Haynes, Matthew, Jones, L, Knibbs, Lucy, McQueen, Alison, Oliver, Catherine, Paradowski, Kerry, Sabit, Ramsey, Williams, Jenny, Jones, Ian, Milligan, Lea, Harris, Edward, Sampson, Claire, Davies, Ellie, Evenden, Cerys, Hancock, Alyson, Hancock, Kia, Lynch, Ceri, Rees, Meryl, Roche, Lisa, Stroud, Natalie, Thomas-Woods, T, Heller, Simon, Chalder, Trudie, Shah, Kamini, Robertson, Elizabeth, Young, Bob, Babores, Marta, Holland, Maureen, Keenan, Natalie, Shashaa, Sharlene, Wassall, Helen, Austin, Liam, Beranova, Eva, Cosier, Tracey, Deery, Joanne, Hazelton, Tracy, Price, Carly, Ramos, Hazel, Solly, Reanne, Turney, Sharon, Weston, Heather, Coughlan, Eamon, Ralser, Markus, Pearce, Lorraine, Pugmire, S, Stoker, Wendy, Wilson, Ann, McCormick, W, Fraile, Eva, Ugoji, Jacinta, Aguilar Jimenez, Laura, Arbane, Gill, Betts, Sarah, Bisnauthsing, Karen, Dewar, A, Hart, Nicholas, Kaltsakas, G, Kerslake, Helen, Magtoto, Murphy, Marino, Philip, Martinez, L M, Ostermann, Marlies, Rossdale, Jennifer, Solano, Teresa, Alvarez Corral, Maria, Arias, Ava Maria, Bevan, Emily, Griffin, Denise, Martin, Jane, Owen, J, Payne, Sheila, Prabhu, A, Reed, Annabel, Storrar, Will, Williams, Nick, Wrey Brown, Caroline, Burdett, Tracy, Featherstone, James, Lawson, Cathy, Layton, Alison, Mills, Clare, Stephenson, Lorraine, Ellis, Yvette, Atkin, Paul, Brindle, K, Crooks, Michael, Drury, Katie, Easom, Nicholas, Flockton, Rachel, Holdsworth, L, Richards, A, Sykes, D L, Thackray-Nocera, Susannah, Wright, C, Coetzee, S, Davies, Kim, Hughes, Rachel Ann, Loosley, Ronda, McGuinness, Heather, Mohamed, Abdelrahman, O'Brien, Linda, Omar, Zohra, Perkins, Emma, Phipps, Janet, Ross, Gavin, Taylor, Abigail, Tench, Helen, Wolf-Roberts, Rebecca, Burden, L, Calvelo, Ellen, Card, Bethany, Carr, Caitlin, Chilvers, Edwin, Copeland, Donna, Cullinan, P, Daly, Patrick, Evison, Lynsey, Fayzan, Tamanah, Gordon, Hussain, Haq, Sulaimaan, Jenkins, Gisli, King, Clara, Kon, Onn Min, March, Katherine, Mariveles, Myril, McLeavey, Laura, Mohamed, Noura, Moriera, Silvia, Munawar, Unber, Nunag, Jose Lloyd, Nwanguma, Uchechi, Orriss-Dib, Lorna, Ross, Alexandra, Roy, Maura, Russell, Emily, Samuel, Katherine, Schronce, J, Simpson, Neil, Tarusan, Lawrence, Thomas, David, Wood, Chloe, Yasmin, Najira, Altmann, Danny, Howard, Luke, Johnston, Desmond, Lingford-Hughes, Anne, Man, William, Mitchell, Jane, Molyneaux, Philip, Nicolaou, Christos, O'Regan, D P, Price, L, Quint, Jenni, Smith, David, Thwaites, Ryan, Valabhji, Jonathon, Walsh, Simon, Efstathiou, Claudia, Liew, Felicity, Frankel, Anew, Lightstone, Liz, McAdoo, Steve, Wilkins, Martin, Willicombe, Michelle, Touyz, R, Guerdette, Anne-Marie, Hewitt, Melanie, Reddy, R, Warwick, Katie, White, Sonia, McMahon, Aisling, Adeyemi, Oluwaseun, Adrego, Rita, Assefa-Kebede, Hosanna, Breeze, Jonathon, Byrne, S, Dulawan, Pearl, Hoare, Amy, Jolley, Caroline, Knighton, Abigail, Patale, Sheetal, Peralta, Ida, Powell, Natassia, Ramos, Albert, Shevket, K, Speranza, Fabio, Te, Amelie, Malim, M, Bramham, Kate, Brown, M, Ismail, Khalida, Nicholson, Tim, Pariante, Carmen, Sharpe, Claire, Wessely, Simon, Whitney, J, Shah, Ajay, Chiribiri, A, O'Brien, C, Hayday, A, Ashworth, Andrew, Beirne, Paul, Clarke, Jude, Coupland, C, Dalton, Matthhew, Favager, Clair, Glossop, Jodie, Greenwood, John, Hall, Lucy, Hardy, Tim, Humphries, Amy, Murira, Jennifer, Peckham, Dan, Plein, S, Rangeley, Jade, Saalmink, Gwen, Tan, Ai Lyn, Wade, Elaine, Whittam, Beverley, Window, Nicola, Woods, Janet, Coakley, G, Turtle, Lance, Allerton, Lisa, Allt, Ann Marie, Beadsworth, M, Berridge, Anthony, Brown, Jo, Cooper, Shirley, Cross, Andy, Defres, Sylviane, Dobson, S L, Earley, Joanne, French, N, Greenhalf, William, Hainey, Kera, Hardwick, Hayley, Hawkes, Jenny, Highett, Victoria, Kaprowska, Sabina, Key, Angela, Lavelle-Langham, Lara, Lewis-Burke, N, Madzamba, Gladys, Malein, Flora, Marsh, Sophie, Mears, Chloe, Melling, Lucy, Noonan, Matthew, Poll, L, Pratt, James, Richardson, Emma, Rowe, Anna, Semple, Calum, Shaw, Victoria, Tripp, K A, Wajero, Lilian, Williams-Howard, S A, Wootton, Dan, Wyles, J, Diwanji, Shalin, Gurram, Sambasivarao, Papineni, Padmasayee, Quaid, Sheena, Tiongson, Gerlynn, Watson, Ekaterina, Briggs, Andrew, Marks, Michael, Hastie, Claire, Rogers, Natalie, Smith, Nikki, Stensel, David, Bishop, Lettie, McIvor, Katherine, Rivera-Ortega, Pilar, Al-Sheklly, Bashar, Avram, Cristina, Blaikely, John, Buch, M, Choudhury, N, Faluyi, David, Felton, T, Gorsuch, T, Hanley, Neil, Horsley, Alex, Hussell, Tracy, Kausar, Zunaira, Odell, Natasha, Osbourne, Rebecca, Piper Hanley, Karen, Radhakrishnan, K, Stockdale, Sue, Kabir, Thomas, Scott, Janet, Stewart, Iain, Openshaw, Peter, Burn, David, Ayoub, A, Brown, J, Burns, G, Davies, Gareth, De Soyza, Anthony, Echevarria, Carlos, Fisher, Helen, Francis, C, Greenhalgh, Alan, Hogarth, Philip, Hughes, Joan, Jiwa, Kasim, Jones, G, MacGowan, G, Price, D, Sayer, Avan, Simpson, John, Tedd, H, Thomas, S, West, Sophie, Witham, M, Wright, S, Young, A, McMahon, Michael, Neill, Paula, Anderson, David, Basu, Neil, Bayes, Hannah, Brown, Ammani, Dougherty, Andrew, Fallon, K, Gilmour, L, Grieve, D, Mangion, K, Morrow, A, Sykes, R, Berry, Colin, McInnes, I B, Scott, Kathryn, Barrett, Fiona, Donaldson, A, Sage, Beth, Bell, Murdina, Brown, Angela, Brown, M, Hamil, R, Leitch, Karen, Macliver, L, Patel, Manish, Quigley, Jackie, Smith, Andrew, Welsh, B, Choudhury, Gaunab, Clohisey, S, Deans, Andrew, Docherty, Annemarie, Furniss, J, Harrison, Ewen, Kelly, S, Sheikh, Aziz, Chalmers, James, Connell, David, Deas, C, Elliott, Anne, George, J, Mohammed, S, Rowland, J, Solstice, AR, Sutherland, Debbie, Tee, Caroline, Bunker, Jenny, Gill, Rhyan, Nathu, Rashmita, Holmes, Katie, Adamali, H, Arnold, David, Barratt, Shaney, Dipper, A, Dunn, Sarah, Maskell, Nick, Morley, Anna, Morrison, Leigh, Stadon, Louise, Waterson, Samuel, Welch, H, Jayaraman, Bhagy, Light, Tessa, Vogiatzis, Ioannis, Almeida, Paula, Bolton, Charlotte, Hosseini, Akram, Matthews, Laura, Needham, Robert, Shaw, Karen, Thomas, Andrew, Bonnington, J, Chrystal, Melanie, Dupont, Catherine, Greenhaff, Paul, Gupta, Ayushman, Jang, W, Linford, S, Nikolaidis, Athanasios, Prosper, Sabrina, Burns, A, Kanellakis, N, Ferreira, V, Nikolaidou, C, Xie, C, Ainsworth, Mark, Alamoudi, Asma, Bloss, Angela, Carter, Penny, Cassar, M, Chen, Jin, Conneh, Florence, Dong, T, Evans, Ranuromanana, Fraser, Emily, Geddes, John, Gleeson, F, Harrison, Paul, Havinden-Williams, May, Ho, Ling Pei, Jezzard, P, Koychev, Ivan, Kurupati, Prathiba, McShane, H, Megson, Clare, Neubauer, Stefan, Nicoll, Debby, Ogg, G, Pacpaco, Edmund, Pavlides, M, Peng, Yanchun, Petousi, Nayia, Pimm, John, Rahman, Najib, Raman, Betty, Rowland, M J, Saunders, Kathryn, Sharpe, Michael, Talbot, Nick, Tunnicliffe, E M, Korszun, Ania, Kerr, Steven, Barker, R E, Cristiano, Daniele, Dormand, N, George, P, Gummadi, Mahitha, Kon, S, Liyanage, Kamal, Nolan, C M, Patel, B, Patel, Suhani, Polgar, Oliver, Price, L, Shah, P, Singh, Suver, Walsh, J A, Gibbons, Michael, Ahmad, Shanaz, Brill, Simon, Hurst, John, Jarvis, Hannah, Lim, Lai, Mandal, S, Matila, Darwin, Olaosebikan, Olaoluwa, Singh, Claire, Laing, C, Baxendale, Helen, Garner, Lucie, Johnson, C, Mackie, J, Michael, Alice, Newman, J, Pack, Jamie, Paques, K, Parfrey, H, Parmar, J, Reddy, A, Halling-Brown, Mark, Dark, P, Diar-Bakerly, Nawar, Evans, D, Hardy, E, Harvey, Alice, Holgate, D, Knight, Sean, Mairs, N, Majeed, N, McMorrow, L, Oxton, J, Pendlebury, Jessica, Summersgill, C, Ugwuoke, R, Whittaker, S, Matimba-Mupaya, Wadzanai, Strong-Sheldrake, Sophia, Chowienczyk, Phillip, Bagshaw, J, Begum, M, Birchall, K, Butcher, Robyn, Carborn, H, Chan, Flora, Chapman, Kerry, Cheng, Yutung, Chetham, Luke, Clark, Cameron, Coburn, Zach, Cole, Joby, Dixon, Myles, Fairman, Alexandra, Finnigan, J, Foot, H, Foote, David, Ford, Amber, Gregory, Rebecca, Harrington, Kate, Haslam, L, Hesselden, L, Hockridge, J, Holbourn, Ailsa, Holroyd-Hind, B, Holt, L, Howell, Alice, Hurditch, E, Ilyas, F, Jarman, Claire, Lawrie, Allan, Lee, Ju Hee, Lee, Elvina, Lenagh, Rebecca, Lye, Alison, Macharia, Irene, Marshall, M, Mbuyisa, Angeline, McNeill, J, Megson, Sharon, Meiring, J, Milner, L, Misra, S, Newell, Helen, Newman, Tom, Norman, C, Nwafor, Lorenza, Pattenadk, Dibya, Plowright, Megan, Porter, Julie, Ravencroft, Phillip, Roddis, C, Rodger, J, Rowland-Jones, Sarah, Saunders, Peter, Sidebottom, J, Smith, Jacqui, Smith, Laurie, Steele, N, Stephens, G, Stimpson, R, Thamu, B, Thompson, A. A. Roger, Tinker, N, Turner, Kim, Turton, Helena, Wade, Phillip, Walker, S, Watson, James, Wilson, Imogen, Zawia, Amira, Allsop, Lynne, Bennett, Kaytie, Buckley, Phil, Flynn, Margaret, Gill, Mandy, Goodwin, Camelia, Greatorex, M, Gregory, Heidi, Heeley, Cheryl, Holloway, Leah, Holmes, Megan, Hutchinson, John, Kirk, Jill, Lovegrove, Wayne, Sewell, Terri Ann, Shelton, Sarah, Sissons, D, Slack, Katie, Smith, Susan, Sowter, D, Turner, Sarah, Whitworth, V, Wynter, Inez, Tomlinson, Johanne, Warburton, Louise, Painter, Sharon, Palmer, Sue, Redwood, Dawn, Tilley, Jo, Vickers, Carinna, Wainwright, Tania, Breen, G, Hotopf, M, Aul, Raminder, Forton, D, Ali, Mariam, Dunleavy, A, Mencias, Mark, Msimanga, N, Samakomva, T, Siddique, Sulman, Tavoukjian, Vera, Teixeira, J, Ahmed, Rubina, Francis, Richard, Connor, Lynda, Cook, Amanda, Davies, Gwyneth, Rees, Tabitha, Thaivalappil, Favas, Thomas, Caradog, McNarry, M, Williams, N, Lewis, Keir, Coulding, Martina, Jones, Heather, Kilroy, Susan, McCormick, Jacqueline, McIntosh, Jerome, Turner, Victoria, Vere, Joanne, Butt, Al-Tahoor, Savill, Heather, Kon, Samantha, Landers, G, Lota, Harpreet, Portukhay, Sofiya, Nasseri, Mariam, Daniels, Alison, Hormis, Anil, Ingham, Julie, Zeidan, Lisa, Chablani, Manish, Osborne, Lynn, Aslani, Shahab, Banerjee, Amita, Batterham, R, Baxter, Gabrielle, Bell, Robert, David, Anthony, Denneny, Emma, Hughes, Alun, Lilaonitkul, W, Mehta, P, Pakzad, Ashkan, Rangelov, Bojidar, Williams, B, Willoughby, James, Xu, Moucheng, Ahwireng, Nyarko, Bang, Dongchun, Basire, Donna, Brown, Jeremy, Chambers, Rachel, Checkley, A, Evans, R, Heightman, M, Hillman, T, Jacob, Joseph, Jastrub, Roman, Lipman, M, Logan, S, Lomas, D, Merida Morillas, Marta, Plant, Hannah, Porter, Joanna, Roy, K, Wall, E, Treibel, T, Ahmad Haider, N, Atkin, Catherine, Baggott, Rhiannon, Bates, Michelle, Botkai, A, Casey, Anna, Cooper, B, Dasgin, Joanne, Dawson, Camilla, Draxlbauer, Katharine, Gautam, N, Hazeldine, J, Hiwot, T, Holden, Sophie, Isaacs, Karen, Jackson, T, Kamwa, Vicky, Lewis, D, Lord, Janet, Madathil, S, McGee, C, Mcgee, K, Neal, Aoife, Newton-Cox, Alex, Nyaboko, Joseph, Parekh, Dhruv, Peterkin, Z, Qureshi, H, Ratcliffe, Liz, Sapey, Elizabeth, Short, J, Soulsby, Tracy, Stockley, J, Suleiman, Zehra, Thompson, Tamika, Ventura, Maximina, Walder, Sinead, Welch, Carly, Wilson, Daisy, Yasmin, S, Yip, Kay Por, Chaudhuri, N, Childs, Caroline, Djukanovic, R, Fletcher, S, Harvey, Matt, Jones, Mark, Marouzet, Elizabeth, Marshall, B, Samuel, Reena, Sass, T, Wallis, Tim, Wheeler, Helen, Steeds, R, Beckett, Paul, Dickens, Caroline, Nanda, Uttam, Aljaroof, M, Armstrong, Natalie, Arnold, H, Aung, Hnin, Bakali, Majda, Bakau, M, Baldry, E, Baldwin, Molly, Bourne, Charlotte, Bourne, Michelle, Brightling, Chris, Brunskill, Nigel, Cairns, P, Carr, Liesel, Charalambou, Amanda, Christie, C, Davies, Melanie, Daynes, Enya, Diver, Sarah, Dowling, Rachael, Edwards, Sarah, Edwardson, C, Elneima, Omer, Evans, H, Evans, Rachael, Finch, J, Glover, Sarah, Goodman, Nicola, Gooptu, Bibek, Greening, Neil, Hadley, Kate, Haldar, Pranab, Hargadon, Beverley, Harris, Victoria, Houchen-Wolloff, Linzy, Ibrahim, W, Ingram, L, Khunti, Kamlesh, Lea, A, Lee, D, McAuley, Hamish, McCann, Gerry, McCourt, P, Mcnally, Teresa, Mills, George, Monteiro, Will, Pareek, Manish, Parker, S, Prickett, Anne, Qureshi, I N, Rowland, A, Russell, Richard, Sereno, Marco, Shikotra, Aarti, Siddiqui, Salman, Singapuri, Ananga, Singh, Sally, Skeemer, J, Soares, M, Stringer, E, Thornton, T, Tobin, Martin, Ward, T J C, Woodhead, F, Yates, Tom, Yousuf, A J, Broome, Mattew, McArdle, Paul, Thickett, David, Upthegrove, Rachel, Wilkinson, Dan, Moss, Paul, Wraith, David, Evans, Jonathon, Bullmore, Ed, Heeney, Jonathon, Langenberg, Claudia, Schwaeble, William, Summers, Charlotte, Weir McCall, J, Adeloye, Davies, Newby, D E, Pius, Riinu, Rudan, Igor, Shankar-Hari, Manu, Sudlow, Catherine, Thorpe, Mat, Walmsley, Sarah, Zheng, Bang, Allan, Louise, Ballard, Clive, McGovern, Andrew, Dennis, J, Cavanagh, Jonathon, MacDonald, S, O'Donnell, Kate, Petrie, John, Sattar, Naveed, Spears, Mark, Guthrie, Elspeth, Henderson, Max, Allen, Richard, Bingham, Michelle, Brugha, Terry, Finney, Selina, Free, Rob, Jones, Don, Lawson, Claire, Lucy, Gardiner, Moss, Alistair, Mukaetova-Ladinska, Elizabeta, Novotny, Petr, Overton, Charlotte, Pearl, John, Plekhanova, Tatiana, Richardson, M, Samani, Nilesh, Sargant, Jack, Sharma, M, Steiner, Mike, Taylor, Chris, Terry, Sarah, Tong, C, Turner, E, Wormleighton, J, Zhao, Bang, Ntotsis, Kimon, Saunders, Ruth, Lozano-Rojas, Daniel, Goemans, Anne, Cuthbertson, D, Kemp, G, McArdle, Anne, Michael, Benedict, Reynolds, Will, Spencer, Lisa, Vinson, Ben, Ashworth, M, Abel, Kathryn, Chinoy, H, Deakin, Bill, Harvie, M, Miller, C A, Stanel, Stefan, Barran, Perdita, Trivedi, Drupad, McAllister-Williams, Hamish, Paddick, Stella-Maria, Rostron, Anthony, Taylor, John Paul, Baguley, David, Coleman, Chris, Cox, E, Fabbri, Laura, Francis, Susan, Hall, Ian, Hufton, E, Johnson, Simon, Khan, Fasih, Kitterick, Paaig, Morriss, Richard, Selby, Nick, Wright, Louise, Antoniades, Charalambos, Bates, A, Beggs, M, Bhui, Kamaldeep, Breeze, Katie, Channon, K M, Clark, David, Fu, X, Husain, Masud, Li, X, Lukaschuk, E, McCracken, Celeste, McGlynn, K, Menke, R, Motohashi, K, Nichols, T E, Ogbole, Godwin, Piechnik, S, Propescu, I, Propescu, J, Samat, A A, Sanders, Z B, Sigfrid, Louise, Webster, M, Kingham, Lucy, Klenerman, Paul, Lamlum, Hanan, Taquet, Maxime, Carson, G, Finnigan, L, Saunders, Laura, Wild, James, Calder, P C, Huneke, Nathan, Simons, Gemma, Baldwin, David, Bain, Steve, Daines, Luke, Bright, E, Crisp, P, Dharmagunawardena, Ruvini, Stern, M, Bailey, Elisabeth, Reddington, Anne, Wight, Andrew, Ashish, A, Cooper, Josh, Robinson, Emma, Broadley, Andrew, Barman, Laura, Brookes, Claire, Elliott, K, Griffiths, L, Guy, Zoe, Howard, Kate, Ionita, Diana, Redfearn, Heidi, Sarginson, Carol, and Turnbull, Alison
- Abstract
COVID-19 is known to be associated with increased risks of cognitive and psychiatric outcomes after the acute phase of disease. We aimed to assess whether these symptoms can emerge or persist more than 1 year after hospitalisation for COVID-19, to identify which early aspects of COVID-19 illness predict longer-term symptoms, and to establish how these symptoms relate to occupational functioning.
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- 2024
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25. Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis
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Beale, Mathew A., Marks, Michael, Cole, Michelle J., Lee, Min-Kuang, Pitt, Rachel, Ruis, Christopher, Balla, Eszter, Crucitti, Tania, Ewens, Michael, Fernández-Naval, Candela, Grankvist, Anna, Guiver, Malcolm, Kenyon, Chris R., Khairullin, Rafil, Kularatne, Ranmini, Arando, Maider, Molini, Barbara J., Obukhov, Andrey, Page, Emma E., Petrovay, Fruzsina, Rietmeijer, Cornelis, Rowley, Dominic, Shokoples, Sandy, Smit, Erasmus, Sweeney, Emma L., Taiaroa, George, Vera, Jaime H., Wennerås, Christine, Whiley, David M., Williamson, Deborah A., Hughes, Gwenda, Naidu, Prenilla, Unemo, Magnus, Krajden, Mel, Lukehart, Sheila A., Morshed, Muhammad G., Fifer, Helen, and Thomson, Nicholas R.
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- 2021
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26. Concurrent outbreaks of mpox in Africa—an update
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Beiras, Camila G, Malembi, Emile, Escrig-Sarreta, Roser, Ahuka, Steve, Mbala, Placide, Mavoko, Hypolite M, Subissi, Lorenzo, Abecasis, Ana B, Marks, Michael, and Mitjà, Oriol
- Abstract
In this Review, we examine the concurrent outbreaks of mpox in Africa, focusing on clade 1a, the newly emerged clade 1b, and clade 2b lineage A, and how they differ from the 2022 global outbreak caused by clade 2b lineage B.1. Historically, clades 1a and 2a have caused sporadic, small outbreaks in central and west Africa, respectively, primarily through zoonotic transmission. Clade 2b first caused an outbreak in Nigeria in 2017, and later spread globally via sexual contact in 2022. In August, 2024, WHO declared a global health emergency due to the newly identified clade 1b outbreak in eastern Democratic Republic of the Congo. This outbreak has now expanded to several other countries and is spreading through direct and sexual contact in urban centres and refugee camps. Clades, route of exposure, infectious dose, and host immune response are the main factors influencing clinical presentation of mpox. For clades 1a and 2a, zoonotic transmission plays an important role, whereas for clades 1b and 2b, the spread occurs through sustained human-to-human transmission without zoonotic exposure. For both clades 1a and 2a, lesions have a generalised centrifugal distribution, whereas for clade 2b they are mainly localised to the anogenital area. For clade 1b, data are still emerging, but current cases show a mix of localised lesions and centrifugal distribution. The severity of the disease is higher for clade 1a (case fatality rate up to 12%) compared with other clades (case fatality rates 0–3·6%). Diagnostic challenges include false negative results for clade 1b with existing PCR assays and poor testing access in remote areas. Tecovirimat, the primary antiviral during the 2022 outbreak, has shown reduced effectiveness against clade 1a in preliminary study results, whereas its efficacy against other clades is still under investigation. The modified vaccinia Ankara–Bavarian Nordic vaccine has been shown to be up to 90% effective against clade 2b after two doses and is safe for children, although its effectiveness drops to 20% when used as post-exposure prophylaxis. Given the evolving nature of the monkeypox virus, ongoing research and strong public health responses are key to managing potential future outbreaks.
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- 2025
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27. M-dwarf binaries as tracers of star and brown dwarf formation
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Marks, Michael, Janson, Markus, Kroupa, Pavel, Leigh, Nathan, and Thies, Ingo
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The separation distribution for M-dwarf binaries in the ASTRALUX survey is narrower and peaking at smaller separations than the distribution for solar-type binaries. This is often interpreted to mean that M-dwarfs constitute a continuous transition from brown dwarfs (BDs) to stars. Here a prediction for the M-dwarf separation distribution is presented, using a dynamical population synthesis (DPS) model in which "star-like" binaries with late-type primaries ($\lesssim1.5 M_{\rm sun}$) follow universal initial distribution functions and are dynamically processed in their birth embedded clusters. A separate "BD-like" population has both its own distribution functions for binaries and initial mass function (IMF), which overlaps in mass with the IMF for stars. Combining these two formation modes results in a peak on top of a wider separation distribution for late M-dwarfs consistent with the late ASTRALUX sample. The DPS separation distribution for early M-dwarfs shows no such peak and is in agreement with the M-dwarfs in Multiples (MinMS) data. We note that the latter survey is potentially in tension with the early ASTRALUX data. Concluding, the ASTRALUX and MinMS data are unable to unambiguously distinguish whether or not BDs are a continuous extension of the stellar IMF. Future observational efforts are needed to fully answer this interesting question. The DPS model predicts that binaries outside the sensitivity range of the ASTRALUX survey remain to be detected. For application to future data, we present a means to observationally measure the overlap of the putative BD-like branch and the stellar branch. We discuss the meaning of universal star formation and distribution functions., Comment: accepted for publication in MNRAS; 13 pages; 7 figures; 1 table
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- 2015
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28. Bad people doing good things: Attributions about people with immoral traits
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An, Sieun, Marks, Michael J., Trafimow, David, and Fedyk, Mark
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- 2021
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29. A retrospective cohort study of risk factors for mortality among nursing homes exposed to COVID-19 in Spain
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Suñer, Clara, Ouchi, Dan, Mas, Miquel Àngel, Lopez Alarcon, Rosa, Massot Mesquida, Mireia, Prat, Núria, Bonet-Simó, Josep Maria, Expósito Izquierdo, Marta, Garcia Sánchez, Irene, Rodoreda Noguerola, Sara, Teixidó Colet, Montserrat, Verdaguer Puigvendrelló, Joaquim, Henríquez, Norma, Miralles, Ramón, Negredo, Eugènia, Noguera-Julian, Marc, Marks, Michael, Estrada, Oriol, Ara, Jordi, and Mitjà, Oriol
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- 2021
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30. Intravenous tPA (Tissue-Type Plasminogen Activator) Correlates With Favorable Venous Outflow Profiles in Acute Ischemic Stroke
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Faizy, Tobias D., Mlynash, Michael, Marks, Michael P., Christensen, Soren, Kabiri, Reza, Kuraitis, Gabriella M., Broocks, Gabriel, Winkelmeier, Laurens, Geest, Vincent, Nawabi, Jawed, Lansberg, Maarten G., Albers, Gregory W., Fiehler, Jens, Wintermark, Max, and Heit, Jeremy J.
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- 2022
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31. Characterizing the Brown Dwarf Formation Channels from the Initial Mass Function and Binary-star Dynamics
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Thies, Ingo, Pflamm-Altenburg, Jan, Kroupa, Pavel, and Marks, Michael
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The stellar initial mass function (IMF) is a key property of stellar populations. There is growing evidence that the classical star-formation mechanism by the direct cloud fragmentation process has difficulties reproducing the observed abundance and binary properties of brown dwarfs and very-low-mass stars. In particular, recent analytical derivations of the stellar IMF exhibit a deficit of brown dwarfs compared to observational data. Here we derive the residual mass function of brown dwarfs as an empirical measure of the brown dwarf deficiency in recent star-formation models with respect to observations and show that it is compatible with the substellar part of the Thies-Kroupa IMF and the mass function obtained by numerical simulations. We conclude that the existing models may be further improved by including a substellar correction term that accounts for additional formation channels like disk or filament fragmentation. The term "peripheral fragmentation" is introduced here for such additional formation channels. In addition, we present an updated analytical model of stellar and substellar binarity. The resulting binary fraction and the dynamically evolved companion mass-ratio distribution are in good agreement with observational data on stellar and very-low-mass binaries in the Galactic field, in clusters, and in dynamically unprocessed groups of stars if all stars form as binaries with stellar companions. Cautionary notes are given on the proper analysis of mass functions and the companion mass-ratio distribution and the interpretation of the results. The existence of accretion disks around young brown dwarfs does not imply that these form just like stars in direct fragmentation., Comment: 10 pages, 9 figures, published in ApJ
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- 2015
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32. Quantitative Characterization of Recanalization and Distal Emboli with a Novel Thrombectomy Device
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Chueh, Ju-Yu, Marosfoi, Miklos G., Anagnostakou, Vania, Arslanian, Rose A., Marks, Michael P., and Gounis, Matthew J
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- 2021
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33. Acute Stroke Imaging Research Roadmap III Imaging Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials: Consensus Recommendations and Further Research Priorities.
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Warach, Steven, Luby, Marie, Albers, Gregory, Bammer, Roland, Bivard, Andrew, Campbell, Bruce, Derdeyn, Colin, Heit, Jeremy, Khatri, Pooja, Lansberg, Maarten, Liebeskind, David, Majoie, Charles, Marks, Michael, Menon, Bijoy, Muir, Keith, Parsons, Mark, Vagal, Achala, Yoo, Albert, Alexandrov, Andrei, Baron, Jean-Claude, Fiorella, David, Furlan, Anthony, Puig, Josep, Schellinger, Peter, and Wintermark, Max
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angiography ,clinical trial ,ischemia ,reperfusion ,stroke ,Clinical Trials as Topic ,Consensus ,Education ,Endovascular Procedures ,Humans ,Neuroimaging ,Stroke ,Thrombolytic Therapy - Abstract
BACKGROUND AND PURPOSE: The Stroke Imaging Research (STIR) group, the Imaging Working Group of StrokeNet, the American Society of Neuroradiology, and the Foundation of the American Society of Neuroradiology sponsored an imaging session and workshop during the Stroke Treatment Academy Industry Roundtable (STAIR) IX on October 5 to 6, 2015 in Washington, DC. The purpose of this roadmap was to focus on the role of imaging in future research and clinical trials. METHODS: This forum brought together stroke neurologists, neuroradiologists, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke (NINDS), industry representatives, and members of the US Food and Drug Administration to discuss STIR priorities in the light of an unprecedented series of positive acute stroke endovascular therapy clinical trials. RESULTS: The imaging session summarized and compared the imaging components of the recent positive endovascular trials and proposed opportunities for pooled analyses. The imaging workshop developed consensus recommendations for optimal imaging methods for the acquisition and analysis of core, mismatch, and collaterals across multiple modalities, and also a standardized approach for measuring the final infarct volume in prospective clinical trials. CONCLUSIONS: Recent positive acute stroke endovascular clinical trials have demonstrated the added value of neurovascular imaging. The optimal imaging profile for endovascular treatment includes large vessel occlusion, smaller core, good collaterals, and large penumbra. However, equivalent definitions for the imaging profile parameters across modalities are needed, and a standardization effort is warranted, potentially leveraging the pooled data resulting from the recent positive endovascular trials.
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- 2016
34. Effect of endovascular reperfusion in relation to site of arterial occlusion
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Lemmens, Robin, Hamilton, Scott A, Liebeskind, David S, Tomsick, Tom A, Demchuk, Andrew M, Nogueira, Raul G, Marks, Michael P, Jahan, Reza, Gralla, Jan, Yoo, Albert J, Yeatts, Sharon D, Palesch, Yuko Y, Saver, Jeffrey L, Pereira, Vitor M, Broderick, Joseph P, Albers, Gregory W, and Lansberg, Maarten G
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Trials and Supportive Activities ,Neurosciences ,Stroke ,Clinical Research ,Brain Disorders ,Cardiovascular ,Arterial Occlusive Diseases ,Carotid Artery ,Internal ,Endovascular Procedures ,Female ,Humans ,Infarction ,Middle Cerebral Artery ,Male ,Prospective Studies ,Randomized Controlled Trials as Topic ,Reperfusion ,Thrombectomy ,Treatment Outcome ,DEFUSE 2 ,IMS III ,STAR ,and SWIFT trialists ,DEFUSE 2 IMS III STAR and SWIFT trialists ,Cognitive Sciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
ObjectiveTo assess whether the association between reperfusion and improved clinical outcomes after stroke differs depending on the site of the arterial occlusive lesion (AOL).MethodsWe pooled data from Solitaire With the Intention for Thrombectomy (SWIFT), Solitaire FR Thrombectomy for Acute Revascularisation (STAR), Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study 2 (DEFUSE 2), and Interventional Management of Stroke Trial (IMS III) to compare the strength of the associations between reperfusion and clinical outcomes in patients with internal carotid artery (ICA), proximal middle cerebral artery (MCA) (M1), and distal MCA (M2/3/4) occlusions.ResultsAmong 710 included patients, the site of the AOL was the ICA in 161, the proximal MCA in 389, and the distal MCA in 160 patients (M2 = 131, M3 = 23, and M4 = 6). Reperfusion was associated with an increase in the rate of good functional outcome (modified Rankin Scale [mRS] score 0-2) in patients with ICA (odds ratio [OR] 3.5, 95% confidence interval [CI] 1.7-7.2) and proximal MCA occlusions (OR 6.2, 95% CI 3.8-10.2), but not in patients with distal MCA occlusions (OR 1.4, 95% CI 0.8-2.6). Among patients with M2 occlusions, a subset of the distal MCA cohort, reperfusion was associated with excellent functional outcome (mRS 0-1; OR 2.2, 95% CI 1.0-4.7).ConclusionsThe association between endovascular reperfusion and better clinical outcomes is more profound in patients with ICA and proximal MCA occlusions compared to patients with distal MCA occlusions. Because there are limited data from randomized controlled trials on the effect of endovascular therapy in patients with distal MCA occlusions, these results underscore the need for inclusion of this subgroup in future endovascular therapy trials.
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- 2016
35. Monte Carlo modelling of globular star clusters - many primordial binaries, IMBH formation
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Giersz, Mirek, Leigh, Nathan, Marks, Michael, Hypki, Arkadiusz, and Askar, Abbas
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Astrophysics - Astrophysics of Galaxies - Abstract
We will discuss the evolution of star clusters with an large initial binary fraction, up to 95%. The initial binary population is chosen to follow the invariant orbital-parameter distributions suggested by Kroupa (1995). The Monte Carlo MOCCA simulations of star cluster evolution are compared to the observations of Milone et al. (2012) for photometric binaries. It is demonstrated that the observed dependence on cluster mass of both the binary fraction and the ratio of the binary fractions inside and outside of the half mass radius are well recovered by the MOCCA simulations. This is due to a rapid decrease in the initial binary fraction due to the strong density-dependent destruction of wide binaries described by Marks, Kroupa & Oh (2011). We also discuss a new scenario for the formation of intermediate mass black holes in dense star clusters. In this scenario, intermediate mass black holes are formed as a result of dynamical interactions of hard binaries containing a stellar mass black hole, with other stars and binaries. We will discuss the necessary conditions to initiate the process of intermediate mass black hole formation and the dependence of its mass accretion rate on the global cluster properties., Comment: 12 pages and 7 figures. Presented at IAU312, to be published as Conference Proceedings
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- 2014
36. The state of globular clusters at birth II: primordial binaries
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Leigh, Nathan W. C., Giersz, Mirek, Marks, Michael, Webb, Jeremy J., Hypki, Arkadiusz, Heinke, Craig O., Kroupa, Pavel, and Sills, Alison
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Astrophysics - Solar and Stellar Astrophysics - Abstract
(abridged) In this paper, we constrain the properties of primordial binary populations in Galactic globular clusters using the MOCCA Monte Carlo code for cluster evolution. Our results are compared to the observations of Milone et al. (2012) using the photometric binary populations as proxies for the true underlying distributions, in order to test the hypothesis that the data are consistent with an universal initial binary fraction near unity and the binary orbital parameter distributions of Kroupa (1995). With the exception of a few possible outliers, we find that the data are to first-order consistent with the universality hypothesis. Specifically, the present-day binary fractions inside the half-mass radius r$_{\rm h}$ can be reproduced assuming either high initial binary fractions near unity with a dominant soft binary component as in the Kroupa distribution combined with high initial densities (10$^4$-10$^6$ M$_{\odot}$ pc$^{-3}$), or low initial binary fractions ($\sim$ 5-10%) with a dominant hard binary component combined with moderate initial densities near their present-day values (10$^2$-10$^3$ M$_{\odot}$ pc$^{-3}$). This apparent degeneracy can be broken using the binary fractions outside r$_{\rm h}$- only high initial binary fractions with a significant soft component combined with high initial densities can contribute to reproducing the observed anti-correlation between the binary fractions outside r$_{\rm h}$ and the total cluster mass. We further illustrate using the simulated present-day binary orbital parameter distributions and the technique introduced in Leigh et al. (2012) that the relative fractions of hard and soft binaries can be used to further constrain the initial cluster density and mass-density relation. Our results favour an initial mass-density relation of the form r$_{\rm h} \propto$ M$_{\rm clus}^{\alpha}$ with $\alpha <$ 1/3., Comment: 17 pages; 5 figures; 1 table; accepted for publication in MNRAS
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- 2014
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37. Revisiting the universality of (multiple) star formation in present-day star formation regions
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Marks, Michael, Leigh, Nathan, Giersz, Mirek, Pfalzner, Susanne, Pflamm-Altenburg, Jan, and Oh, Seungkyung
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Populations of multiple stars inside clustered regions are known to change through dynamical interactions. The efficiency of binary disruption is thought to be determined by stellar density. King and collaborators recently investigated the multiplicity properties in young star forming regions and in the Galactic field. They concluded that stellar density-dependent modification of a universal initial binary population (the standard or null hypothesis model) cannot explain the observations. We re-visit their results, analyzing the data within the framework of different model assumptions, namely non-universality without dynamical modification and universality with dynamics. We illustrate that the standard model does account for all known populations if regions were significantly denser in the past. Some of the effects of using present-day cluster properties as proxies for their past values are emphasized and that the degeneracy between age and density of a star forming region can not be omitted when interpreting multiplicity data. A new analysis of the Corona Australis region is performed within the standard model. It is found that this region is likely as unevolved as Taurus and an initial density of $\approx190M_{\odot}\;pc^{-3}$ is required to produce the presently observed binary population, which is close to its present-day density., Comment: accepted for publication in MNRAS; 12 pages; 4 figures; 3 tables
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- 2014
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38. Metaphors of Democratization
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Marks, Michael P. and Marks, Michael P.
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- 2018
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39. Metaphors of International Political Economy
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Marks, Michael P. and Marks, Michael P.
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- 2018
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40. The Role of Metaphors in International Relations Theory
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Marks, Michael P. and Marks, Michael P.
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- 2018
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41. Theoretical Reflections
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Marks, Michael P. and Marks, Michael P.
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- 2018
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42. The Significance of Metaphors in International Relations Theory
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Marks, Michael P. and Marks, Michael P.
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- 2018
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43. Resiliency and Retention in Veterans Returning to College: Results of a Pilot Study
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Markel, Nicholas, Trujillo, Ralph, Callahan, Philip, and Marks, Michael
- Abstract
The intent of this pilot program of studies is to transition returning veterans into an academic setting by establishing an academic and social framework to foster resiliency and retention. This curriculum, composed of three courses addressing resiliency, learning-teaching, and leadership, uses a recovery model approach. The program was repeated over two semesters with veterans-only cohorts. The two cohorts demonstrated significant gains in resiliency and unanimously perceived the courses as having improved their likelihood of completing college. Early results show good retention and a strong perception of success and likelihood of graduation. (Contains 2 figures.)
- Published
- 2010
44. Combining Ion Chromatography and Total Reflection X-ray Fluorescence for Detection of Major, Minor and Trace Elements in Quartz-Hosted Fluid Inclusions
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Sara Ladenburger, Walter, Benjamin F., Marks, Michael A. W., and Markl, Gregor
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- 2020
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45. BLOC1S5 pathogenic variants cause a new type of Hermansky–Pudlak syndrome
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Pennamen, Perrine, Le, Linh, Tingaud-Sequeira, Angèle, Fiore, Mathieu, Bauters, Anne, Van Duong Béatrice, Nguyen, Coste, Valentine, Bordet, Jean-Claude, Plaisant, Claudio, Diallo, Modibo, Michaud, Vincent, Trimouille, Aurélien, Lacombe, Didier, Lasseaux, Eulalie, Delevoye, Cédric, Picard, Fanny Morice, Delobel, Bruno, Marks, Michael S., and Arveiler, Benoit
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- 2020
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46. Double Standards in Perceived Traits of Women Labeled Victims Versus Survivors
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Setia, Aanchal, Marks, Michael, and An, Sieun
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- 2020
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47. Case Study: A Hispanic Combat Veteran Returns to College
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Brito, Javier, Callahan, Philip, and Marks, Michael Wm
- Abstract
This exploratory case study focuses on a returning Hispanic combat veteran and his perceptions and experiences regarding transition from a military setting to a higher education setting. Focus is placed on a cohort-based transition educational program of studies designed to provide coping skills that foster resiliency so as to minimize stigmatization and traditional psychological interventions while increasing the likelihood of retention and graduation. While this study looks at a single individual attending the program, his perceptions advise to the efficacy of such an endeavor for returning veterans.
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- 2008
48. Data collection for outbreak investigations: process for defining a minimal data set using a Delphi approach
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Perrocheau, Anne, Brindle, Hannah, Roberts, Chrissy, Murthy, Srinivas, Shetty, Sharmila, Martin, Antonio Isidro Carrion, Marks, Michael, and Schenkel, Karl
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- 2021
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49. Neogene hyperaridity in Arabia drove the directions of mammalian dispersal between Africa and Eurasia
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Böhme, Madelaine, Spassov, Nikolai, Majidifard, Mahmoud Reza, Gärtner, Andreas, Kirscher, Uwe, Marks, Michael, Dietzel, Christian, Uhlig, Gregor, El Atfy, Haytham, Begun, David R., and Winklhofer, Michael
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- 2021
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50. Estimation of scabies prevalence using simplified criteria and mapping procedures in three Pacific and southeast Asian countries
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Tsoi, Shu Ki, Lake, Susanna J., Thean, Li Jun, Matthews, Alexander, Sokana, Oliver, Kama, Mike, Amaral, Salvador, Romani, Lucia, Whitfeld, Margot, Francis, Joshua R., Vaz Nery, Susana, Marks, Michael, Kaldor, John M., Steer, Andrew C., and Engelman, Daniel
- Published
- 2021
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