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Dengue fever is the most important arboviral disease of modernity. It is caused by four serologically distinct viruses transmitted by Aedes mosquitoes. Over 2.3 million cases were reported in the Americas during 2013. More than half of the world’s population is at risk of infection and the vectors’ distributions are increasing. Current prevention strategies involve personal protection and disruption of vector breeding sites as no vaccine is available. Accordingly, it is important to understand the underlying risk factors of dengue prevention if transmission risk is to be reduced. To assess underlying risk factors, three studies were conducted using data from Ribeirao Preto, Brazil. The first characterized epidemiologic patterns of dengue surveillance data that included all reported cases in the city during 2003-2012. The second study employed a negative binomial GLM to assess the potential links between weather and dengue. Finally, a large survey was conducted in 2012 aimed at characterizing population-level knowledge of dengue. Annual dengue incidence varied considerably from