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C2-dissymmetric PyOX-ligands have been applied to the asymmetric Henry reaction. This widely applicable reaction is easy to perform, requires no inert atmospheres or dry solvents, and gives good selectivities. By adjusting ligand side-chains, a significant impact on selectivities was observed.

Preparation of novel chiral gold nanoparticles (AuNP) is described. The major advantage of nanoparticles is to combine the easy handling of solid-supported ligands and the efficiency of soluble ligands, as the molecular size of the support approaches the minimum. This is even of industrial interest, because this kind of technology offers a way of avoiding leaching of the catalyst metal in the reaction and separation of the entire catalyst using simple filtration. In this paper, we describe the attachment of a chiral soluble PyOX-ligand on a nano support via simple ligand exchange. As a result, we achieved a core smaller than ever before in experimental chemistry (1.2 ± 0.2 nm) and promising enantioselectivity in a preliminary test reaction.

A novel supported amino alcohol linker was synthesized and utilized for attachment of picolinic acid derivatives onto different supports. When the resin bound molecule was further activated, the PyOX-moiety could be constructed reliably in enantiopure form. Furthermore, an efficient Pd-catalyzed modification of a picolinic acid derivative is presented.

A short and convenient synthesis of a carboxy functionalized PyOX-core is presented. The carboxy functionality offers a wide variety of possibilities for further modification. In this paper, the core is functionalized with a mercapto tail.

A simple synthesis of a totally new enantiopure compound family, the IndOX compounds, is presented. These chiral compounds can be prepared in two simple steps from commercial starting materials, using no protective groups. The motive for preparing this family is the promising ligand activity of the already known analogs and structural similarity to active pharmaceuticals.

A simple synthesis of a totally new enantiopure compound family, the IndOX compounds, is presented. These chiral compounds can be prepared in two simple steps from commercial starting materials, using no protective groups. The motive for preparing this family is the promising ligand activity of the already known analogs and structural similarity to active pharmaceuticals.