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3. Diagnostic Performance of Magnetic Resonance Imaging for Pediatric Ovarian Neoplasms: A Multi-Institutional Review

Author

Bergus, Katherine C., Knaus, Maria E., Onwuka, Amanda J., Afrazi, Amin, Breech, Lesley, Corkum, Kristine S., Dillon, Patrick A., Ehrlich, Peter F., Fallat, Mary E., Fraser, Jason D., Gadepalli, Samir K., Grabowski, Julia E., Hertweck, S. Paige, Kabre, Rashmi, Lal, Dave R., Landman, Matthew P., Leys, Charles M., Mak, Grace Z., Markel, Troy A., Merchant, Naila, Overman, R. Elliott, Rademacher, Brooks L., Raiji, Manish T., Rymeski, Beth, Sato, Thomas T., Wright, Tiffany, Aldrink, Jennifer H., Hewitt, Geri D., Minneci, Peter C., and Deans, Katherine J.

Published
2024
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5. Relationship between the COVID-19 pandemic and structural inequalities within the pediatric trauma population

Author

Georgeades, Christina, Collings, Amelia T., Farazi, Manzur, Bergner, Carisa, Fallat, Mary E., Minneci, Peter C., Speck, K. Elizabeth, Van Arendonk, Kyle J., Deans, Katherine J., Falcone, Jr., Richard A., Foley, David S., Fraser, Jason D., Gadepalli, Samir K., Keller, Martin S., Kotagal, Meera, Landman, Matthew P., Leys, Charles M., Markel, Troy A., Rubalcava, Nathan S., St. Peter, Shawn D., Sato, Thomas T., and Flynn-O’Brien, Katherine T.

Published
2023
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6. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial.

Author

Blakely, Martin L, Tyson, Jon E, Lally, Kevin P, Hintz, Susan R, Eggleston, Barry, Stevenson, David K, Besner, Gail E, Das, Abhik, Ohls, Robin K, Truog, William E, Nelin, Leif D, Poindexter, Brenda B, Pedroza, Claudia, Walsh, Michele C, Stoll, Barbara J, Geller, Rachel, Kennedy, Kathleen A, Dimmitt, Reed A, Carlo, Waldemar A, Cotten, C Michael, Laptook, Abbot R, Van Meurs, Krisa P, Calkins, Kara L, Sokol, Gregory M, Sanchez, Pablo J, Wyckoff, Myra H, Patel, Ravi M, Frantz, Ivan D, Shankaran, Seetha, D'Angio, Carl T, Yoder, Bradley A, Bell, Edward F, Watterberg, Kristi L, Martin, Colin A, Harmon, Carroll M, Rice, Henry, Kurkchubasche, Arlet G, Sylvester, Karl, Dunn, James CY, Markel, Troy A, Diesen, Diana L, Bhatia, Amina M, Flake, Alan, Chwals, Walter J, Brown, Rebeccah, Bass, Kathryn D, St Peter, Shawn D, Shanti, Christina M, Pegoli, Walter, Skarda, David, Shilyansky, Joel, Lemon, David G, Mosquera, Ricardo A, Peralta-Carcelen, Myriam, Goldstein, Ricki F, Vohr, Betty R, Purdy, Isabell B, Hines, Abbey C, Maitre, Nathalie L, Heyne, Roy J, DeMauro, Sara B, McGowan, Elisabeth C, Yolton, Kimberly, Kilbride, Howard W, Natarajan, Girija, Yost, Kelley, Winter, Sarah, Colaizy, Tarah T, Laughon, Matthew M, Lakshminrusimha, Satyanarayana, and Higgins, Rosemary D

Subjects
Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Infant Mortality, Rare Diseases, Digestive Diseases, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Clinical Trials and Supportive Activities, Good Health and Well Being, Drainage, Enterocolitis, Necrotizing, Feasibility Studies, Female, Humans, Infant, Extremely Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Intestinal Perforation, Laparotomy, Male, Neurodevelopmental Disorders, Survival Rate, Treatment Outcome, isolated intestinal perforation, neonatal surgery, premature infant, randomized clinical trial, surgical necrotizing enterocolitis, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network, Medical and Health Sciences, Surgery
Abstract

ObjectiveThe aim of this study was to determine which initial surgical treatment results in the lowest rate of death or neurodevelopmental impairment (NDI) in premature infants with necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP).Summary background dataThe impact of initial laparotomy versus peritoneal drainage for NEC or IP on the rate of death or NDI in extremely low birth weight infants is unknown.MethodsWe conducted the largest feasible randomized trial in 20 US centers, comparing initial laparotomy versus peritoneal drainage. The primary outcome was a composite of death or NDI at 18 to 22 months corrected age, analyzed using prespecified frequentist and Bayesian approaches.ResultsOf 992 eligible infants, 310 were randomized and 96% had primary outcome assessed. Death or NDI occurred in 69% of infants in the laparotomy group versus 70% with drainage [adjusted relative risk (aRR) 1.0; 95% confidence interval (CI): 0.87-1.14]. A preplanned analysis identified an interaction between preoperative diagnosis and treatment group (P = 0.03). With a preoperative diagnosis of NEC, death or NDI occurred in 69% after laparotomy versus 85% with drainage (aRR 0.81; 95% CI: 0.64-1.04). The Bayesian posterior probability that laparotomy was beneficial (risk difference

Published
2021

9. Use and Accuracy of Intraoperative Frozen Section Analysis for Ovarian Masses in Children and Adolescents

Author

Gil, Lindsay A., Lutz, Carley M., Dillon, Patrick A., Downard, Cynthia D., Ehrlich, Peter F., Fallat, Mary E., Fraser, Jason D., Grabowski, Julia E., Helmrath, Michael A., Hertweck, S. Paige, Hirschl, Ronald B., Kabre, Rashmi, Lal, Dave R., Landman, Matthew P., Lawrence, Amy E., Leys, Charles M., Mak, Grace Z., Markel, Troy A., Raiji, Manish T., Rymeski, Beth, Saito, Jacqueline M., Sato, Thomas T., St. Peter, Shawn D., Stafford, Linda M. Cherney, Deans, Katherine J., Minneci, Peter C., Hewitt, Geri D., and Aldrink, Jennifer H.

Published
2023
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12. Pediatric Injury Transfer Patterns During the COVID-19 Pandemic: An Interrupted time Series Analysis

Author

Flynn-O’Brien, Katherine T., Collings, Amelia T., Farazi, Manzur, Fallat, Mary E., Minneci, Peter C., Speck, K. Elizabeth, Van Arendonk, Kyle, Deans, Katherine J., Falcone, Richard A., Jr., Foley, David S., Fraser, Jason D., Gadepalli, Samir, Keller, Martin S., Kotagal, Meera, Landman, Matthew P., Leys, Charles M., Markel, Troy A., Rubalcava, Nathan, St. Peter, Shawn D., and Sato, Thomas T.

Published
2023
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13. Thoracoscopy versus thoracotomy for esophageal atresia and tracheoesophageal fistula: Outcomes from the Midwest Pediatric Surgery Consortium

Author

Marquart, John P., Bowder, Alexis N, Bence, Christina M., St. Peter, Shawn D., Gadepalli, Samir K., Sato, Thomas T., Szabo, Aniko, Minneci, Peter C., Hirschl, Ronald B., Rymeski, Beth A., Downard, Cynthia D., Markel, Troy A., Deans, Katherine J., Fallat, Mary E., Fraser, Jason D., Grabowski, Julia E., Helmrath, Michael A., Kabre, Rashmi D., Kohler, Jonathan E., Landman, Matthew P., Lawrence, Amy E., Leys, Charles M., Mak, Grace Z., Port, Elissa, Saito, Jacqueline, Silverberg, Jared, Slidell, Mark B., Wright, Tiffany N., and Lal, Dave R.

Published
2023
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16. Evaluating the risk of peri-umbilical hernia after sutured or sutureless gastroschisis closure

Author

Fraser, James A., Deans, Katherine J., Fallat, Mary E., Helmrath, Michael, Kabre, Rashmi, Leys, Charles M., Markel, Troy A., Dillon, Patrick A., Downard, Cynthia, Wright, Tiffany N., Gadepalli, Samir K., Grabowski, Julia E., Hirschl, Ronald, Johnson, Kevin N., Kohler, Jonathan E., Landman, Matthew P., Mak, Grace Z., Minneci, Peter C., Rymeski, Beth, Sato, Thomas T., Slater, Bethany J., Peter, Shawn D. St, and Fraser, Jason D.

Published
2022
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17. Multi-Institutional Review of the Preoperative Diagnostic Accuracy for Pediatric Ovarian Mature Cystic Teratomas

Author

Knaus, Maria E., Onwuka, Amanda J., Afrazi, Amin, Breech, Lesley, Corkum, Kristine S., Dillon, Patrick A., Ehrlich, Peter F., Fallat, Mary E., Fraser, Jason D., Gadepalli, Samir K., Grabowski, Julia E., Hertweck, S. Paige, Kabre, Rashmi, Lal, Dave R., Landman, Matthew P., Lawrence, Amy E., Leys, Charles M., Mak, Grace Z., Markel, Troy A., Merchan, Naila, Overman, R. Elliott, Rademacher, Brooks L., Raiji, Manish T., Rymeski, Beth, Sato, Thomas T., Scannel, Madeline, Schikler, Allegra G., Sujka, Joseph A., Wright, Tiffany, Aldrink, Jennifer H., Hewitt, Geri D., Minneci, Peter C., and Deans, Katherine J.

Published
2022
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18. The COVID-19 pandemic and associated rise in pediatric firearm injuries: A multi-institutional study

Author

Collings, Amelia T., Farazi, Manzur, Van Arendonk, Kyle J., Fallat, Mary E., Minneci, Peter C., Sato, Thomas T., Speck, K. Elizabeth, Deans, Katherine J., Falcone Jr, Richard A., Foley, David S., Fraser, Jason D., Gadepalli, Samir K., Keller, Martin S., Kotagal, Meera, Landman, Matthew P., Leys, Charles M., Markel, Troy A., Rubalcava, Nathan, St. Peter, Shawn D., and Flynn-O'Brien, Katherine T.

Published
2022
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19. Acid suppression duration does not alter anastomotic stricture rates after esophageal atresia with distal tracheoesophageal fistula repair: A prospective multi-institutional cohort study

Author

Bowder, Alexis N, Bence, Christina M., Rymeski, Beth A, Gadepalli, Samir K., Sato, Thomas T., Szabo, Aniko, Arendonk, Kyle Van, Minneci, Peter C., Downard, Cynthia D., Hirschl, Ronald B., Markel, Troy, Courtney, Cathleen M., Deans, Katherine J., Fallat, Mary E., Fraser, Jason D., Grabowski, Julia E., Helmrath, Michael A., Kabre, Rashmi D., Kohler, Jonathan E., Landman, Matthew P., Lawrence, Amy E., Leys, Charles M., Mak, Grace, Port, Elissa, Saito, Jacqueline, Silverberg, Jared, Slidell, Mark B., St Peter, Shawn D., Troutt, Misty, Wright, Tiffany N., and Lal, Dave R.

Published
2022
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20. Laparoscopy versus laparotomy for pediatric ovarian dermoids

Author

Knaus, Maria E., Onwuka, Amanda J., Afrazi, Amin, Breech, Lesley, Corkum, Kristine S., Dillon, Patrick A., Ehrlich, Peter F., Fallat, Mary E., Fraser, Jason D., Gadepalli, Samir K., Grabowski, Julia E., Hertweck, S. Paige, Kabre, Rashmi, Lal, Dave R., Landman, Matthew P., Lawrence, Amy E., Leys, Charles M., Mak, Grace Z., Markel, Troy A., Merchant, Naila, Elliott Overman, R., Rademacher, Brooks L., Raiji, Manish T., Rymeski, Beth, Sato, Thomas T., Scannell, Madeline, Schikler, Allegra G., Sujka, Joseph A., Wright, Tiffany, Aldrink, Jennifer H., Hewitt, Geri D., Minneci, Peter C., and Deans, Katherine J.

Published
2022
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21. Impact of “Stay-at-Home” orders on non-accidental trauma: A multi-institutional study

Author

Collings, Amelia T., Farazi, Manzur, Van Arendonk, Kyle, Fallat, Mary E., Minneci, Peter C., Sato, Thomas T., Speck, K. Elizabeth, Deans, Katherine J., Falcone, Richard A., Foley, David S., Fraser, Jason D., Keller, Martin S., Kotagal, Meera, Landman, Matthew P., Leys, Charles M., Markel, Troy, Rubalcava, Nathan, St Peter, Shawn D., and Flynn-O'Brien, Katherine T.

Published
2022
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22. Circuit change in neonatal and pediatric extracorporeal membrane oxygenation is associated with adverse outcomes.

Author

Hafezi, Niloufar, Markel, Troy A, Mark, Natalie M, Colgate, Cameron L, Shah, Supriya, Ninad, Nehal, Masso Maldonado, Sarina, and Gray, Brian W

Subjects
*DISEASE risk factors, *RISK assessment, *EXTRACORPOREAL membrane oxygenation, *T-test (Statistics), *HUMAN beings, *MULTIPLE regression analysis, *FISHER exact test, *MEDICAL device removal, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *CHI-squared test, *MANN Whitney U Test, *PEDIATRICS, *INFUSION therapy equipment, *ODDS ratio, *MEDICAL records, *ACQUISITION of data, *STATISTICS, *RESEARCH, *CONFIDENCE intervals, *DATA analysis software, MORTALITY risk factors
Abstract

Introduction: Extracorporeal membrane oxygenation (ECMO) circuits may be changed during the run for multiple reasons; however, these circuit changes may be associated with adverse events. Predictors for undergoing a circuit change (CC) and their outcomes remain unclear. We hypothesized that neonatal and pediatric CC correlates with increased morbidity and mortality. Methods: Pediatric and neonatal patients who underwent one ECMO run lasting <30 days at a tertiary children's hospital from 2011 through 2017 were retrospectively reviewed. Bivariate regression analysis evaluated factors associated with ECMO mortality and morbidity. LASSO logistic regression models identified independent risk factors for undergoing a CC. p <.05 was significant. Results: One hundred 85 patients were included; 137 (74%) underwent no CC, while 48 (26%) underwent one or more. Undergoing a CC was associated with longer ECMO duration (p <.001), higher blood transfusion volumes (p <.001), increased hemorrhagic complications (p <.001) and increased mortality (p =.002). Increased platelet (p =.001) and FFP (p =.016) transfusion volumes at any time while on ECMO were independent factors associated with undergoing a CC. Conclusions: Changing the circuit during the ECMO run occurs frequently and may be associated with poorer outcomes. Understanding the outcomes and predictors for CC may guide management protocols for more efficient circuit changes given its important association with overall outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Venous Thromboembolism Prophylaxis in High-Risk Pediatric Trauma Patients.

Author

Witte, Amanda B., Van Arendonk, Kyle, Bergner, Carisa, Bantchev, Martin, Falcone Jr, Richard A., Moody, Suzanne, Hartman, Heather A., Evans, Emily, Thakkar, Rajan, Patterson, Kelli N., Minneci, Peter C., Mak, Grace Z., Slidell, Mark B., Johnson, MacKenton, Landman, Matthew P., Markel, Troy A., Leys, Charles M., Cherney Stafford, Linda, Draper, Jessica, and Foley, David S.

Published
2024
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25. A Multi-institutional Study Evaluating Pediatric Burn Injuries During the COVID-19 Pandemic

Author

Georgeades, Christina M, Collings, Amelia T, Farazi, Manzur, Fallat, Mary E, Minneci, Peter C, Sato, Thomas T, Speck, Karen Elizabeth, Van Arendonk, Kyle, Deans, Katherine J, Falcone, Richard A, Jr, Foley, David S, Fraser, Jason, Gadepalli, Samir, Keller, Martin S, Kotagal, Meera, Landman, Matthew P, Leys, Charles M, Markel, Troy A, Rubalcava, Nathan, St. Peter, Shawn D, and Flynn-O’Brien, Katherine T

Published
2023
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29. Stem Cells and Tissue Engineering

Author

Markel, Troy A., Kao, Lillian, Series Editor, Chen, Herbert, Series Editor, Kennedy, Gregory, editor, Gosain, Ankush, editor, Kibbe, Melina, editor, and LeMaire, Scott A., editor

Published
2019
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37. Diagnostic Performance of Magnetic Resonance Imaging for Pediatric Ovarian Neoplasms: A Multi-Institutional Review

Author

Bergus, Katherine C., primary, Knaus, Maria E., additional, Onwuka, Amanda J., additional, Afrazi, Amin, additional, Breech, Lesley, additional, Corkum, Kristine S., additional, Dillon, Patrick A., additional, Ehrlich, Peter F., additional, Fallat, Mary E., additional, Fraser, Jason D., additional, Gadepalli, Samir K., additional, Grabowski, Julia E., additional, Hertweck, S. Paige, additional, Kabre, Rashmi, additional, Lal, Dave R., additional, Landman, Matthew P., additional, Leys, Charles M., additional, Mak, Grace Z., additional, Markel, Troy A., additional, Merchant, Naila, additional, Overman, R. Elliott, additional, Rademacher, Brooks L., additional, Raiji, Manish T., additional, Rymeski, Beth, additional, Sato, Thomas T., additional, Wright, Tiffany, additional, Aldrink, Jennifer H., additional, Hewitt, Geri D., additional, Minneci, Peter C., additional, and Deans, Katherine J., additional

Published
2023
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49. Role of innate T cells in necrotizing enterocolitis.

Author

Jianyun Liu, Joseph, Sharon, Manohar, Krishna, Lee, Jasmine, Brokaw, John P., Shelley, W. Christopher, and Markel, Troy A.

Subjects
ENTEROCOLITIS, T cells, VERY low birth weight, NEONATAL intensive care units, PREMATURE infants, LITERATURE reviews
Abstract

Necrotizing enterocolitis (NEC) is a destructive gastrointestinal disease primarily affecting preterm babies. Despite advancements in neonatal care, NEC remains a significant cause of morbidity and mortality in neonatal intensive care units worldwide and the etiology of NEC is still unclear. Risk factors for NEC include prematurity, very low birth weight, feeding with formula, intestinal dysbiosis and bacterial infection. A review of the literature would suggest that supplementation of prebiotics and probiotics prevents NEC by altering the immune responses. Innate T cells, a highly conserved subpopulation of T cells that responds quickly to stimulation, develops differently from conventional T cells in neonates. This review aims to provide a succinct overview of innate T cells in neonates, encompassing their phenotypic characteristics, functional roles, likely involvement in the pathogenesis of NEC, and potential therapeutic implications. [ABSTRACT FROM AUTHOR]

Published
2024
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