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1. Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy

Author

M. Naeini, Marjan, Newell, Felicity, Aoude, Lauren G., Bonazzi, Vanessa F., Patel, Kalpana, Lampe, Guy, Koufariotis, Lambros T., Lakis, Vanessa, Addala, Venkateswar, Kondrashova, Olga, Johnston, Rebecca L., Sharma, Sowmya, Brosda, Sandra, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Qinying, Thomas, Janine, Walpole, Euan, Tao Mai, G., Ackland, Stephen P., Martin, Jarad, Burge, Matthew, Finch, Robert, Karapetis, Christos S., Shannon, Jenny, Nott, Louise, Bohmer, Robert, Wilson, Kate, Barnes, Elizabeth, Zalcberg, John R., Mark Smithers, B., Simes, John, Price, Timothy, Gebski, Val, Nones, Katia, Watson, David I., Pearson, John V., Barbour, Andrew P., and Waddell, Nicola

Published
2023
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2. Long–Term Oncologic Outcomes After Isolated Limb Infusion for Locoregionally Metastatic Melanoma: An International Multicenter Analysis

Author

Miura, John T., Kroon, Hidde M., Beasley, Georgia M., Mullen, Dean, Farrow, Norma E., Mosca, Paul J., Lowe, Michael C., Farley, Clara R., Kim, Youngchul, Naqvi, Syeda Mahrukh Hussnain, Potdar, Aishwarya, Daou, Hala, Sun, James, Farma, Jeffrey M., Henderson, Michael A., Speakman, David, Serpell, Jonathan, Delman, Keith A., Mark Smithers, B., Coventry, Brendon J., Tyler, Douglas S., Thompson, John F., and Zager, Jonathan S.

Published
2019
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10. Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society Recommendations

Author

Low, Donald E., primary, Allum, William, additional, De Manzoni, Giovanni, additional, Ferri, Lorenzo, additional, Immanuel, Arul, additional, Kuppusamy, MadhanKumar, additional, Law, Simon, additional, Lindblad, Mats, additional, Maynard, Nick, additional, Neal, Joseph, additional, Pramesh, C. S., additional, Scott, Mike, additional, Mark Smithers, B., additional, Addor, Valérie, additional, and Ljungqvist, Olle, additional

Published
2018
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11. Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts

Author

Carbone, David, primary, Sharpnack, Michael, additional, He, Kai, additional, Butterfield, Lisa H., additional, Eggermont, Alexander M. M., additional, Gonzalez-Cao, Maria, additional, Karachaliou, Niki, additional, Crespo, Guillermo, additional, Aldeguer, Erika, additional, Drozdowskyj, Ana, additional, Giménez-Capitán, Ana, additional, Teixidó, Cristina, additional, Molina-Vila, Miguel Angel, additional, Ramírez, Santiago Viteri, additional, Algarra, Salvador Martin, additional, Pérez-Ruiz, Elisabeth, additional, Márquez-Rodas, Iván, additional, Rodriguez-Abreu, Delvys, additional, Blanco, Remei, additional, Puértolas, Teresa, additional, Royo, Maria Angeles, additional, Rosell, Rafael, additional, Ascierto, Maria Libera, additional, Hamm, Svetlana, additional, Wulff, Tanja, additional, Kronthaler, Kerstin, additional, Schrepfer, Sabine, additional, Parnitzke, Ulrike, additional, Bretz, Anne Catherine, additional, Baumgartner, Roland, additional, Ferrucci, Veronica, additional, Pennino, Francesco Paolo, additional, Dassi, Luisa, additional, Asadzadeh, Fatemeh, additional, Siciliano, Roberto, additional, Carotenuto, Marianeve, additional, Spano, Daniela, additional, Chiarolla, Cristina Maria, additional, Greco, Adelaide, additional, Cantile, Monica, additional, Di Bonito, Maurizio, additional, Botti, Gerardo, additional, Jonathan, Vandenbussche, additional, Kris, Gevaert, additional, Zollo, Massimo, additional, Amaral, Teresa, additional, Tampouri, Ioanna, additional, Keim, Ulrike, additional, Eigentler, Thomas, additional, Garbe, Claus, additional, Forschner, Andrea, additional, Cesano, Alessandra, additional, Warren, Sarah, additional, Moogk, Duane, additional, Li, Kaitao, additional, Yuan, Zhou, additional, Zhong, Shi, additional, Yu, Zhiya, additional, Liadi, Ivan, additional, Rittase, William, additional, Fang, Victoria, additional, Dougherty, Janna, additional, Perez-Garcia, Arianne, additional, Osman, Iman, additional, Varadarajan, Navin, additional, Restifo, Nicholas P., additional, Frey, Alan, additional, Zhu, Cheng, additional, Krogsgaard, Michelle, additional, Vanpouille-Box, Claire, additional, Formenti, Silvia C., additional, Demaria, Sandra, additional, Nigro, Cristiana Lo, additional, Renziehausen, Alexander, additional, Tzakos, Andreas G., additional, Wang, Hexiao, additional, Rao, Bhavya, additional, Matin, Rubeta, additional, Harwood, Catherine, additional, Vivenza, Daniela, additional, Tonissi, Federica, additional, Occelli, Marcella, additional, Weir, Lynda, additional, Li, Su, additional, Sim, Van Ren, additional, O’Neill, Kevin, additional, Evans, Alan, additional, Thompson, Alastair, additional, Szlosarek, Peter, additional, Fleming, Colin, additional, Proby, Charlotte, additional, Syed, Nelofer, additional, Merlano, Marco, additional, Crook, Tim, additional, Ferguson, Robert, additional, Simpson, Danny, additional, Martinez, Carlos, additional, Vogelsang, Matjaz, additional, Kazlow, Esther, additional, Wilson, Melissa, additional, Pavlick, Anna, additional, Weber, Jeffrey, additional, Sullivan, Ryan, additional, Flaherty, Keith, additional, Ribas, Antoni, additional, Kirchhoff, Tomas, additional, D’Avino, Antonio, additional, Guida, Licia, additional, Cosacco, Augusto, additional, D’Aniello, Roberta, additional, Maiolino, Piera, additional, Tramontano, Teresa, additional, Sarno, Maria R., additional, Palazzo, Ida, additional, Di Napoli, Angela, additional, Acunzo, Gianclaudio, additional, De Fina, Mariarosanna, additional, Silvestri, Antonia, additional, Specchia, Monica, additional, Musacchio, Michela, additional, Giglio, Gianfranco, additional, Carrozza, Francesco, additional, Di Lullo, Liberato, additional, De Maddi, Gian Marco, additional, Venturelli, Adele, additional, Gambale, Elisabetta, additional, Gatta, Alessia, additional, Brocco, Davide, additional, Carella, Consiglia, additional, De Tursi, Michele, additional, Gajewski, Thomas F., additional, Cristiani, Costanza M., additional, Tallerico, Rossana, additional, Ventura, Valeria, additional, Capone, Mariaelena, additional, Madonna, Gabriele, additional, Mallardo, Domenico, additional, Selinger, Eliska, additional, Garofalo, Cinzia, additional, Staaf, Elina, additional, Simeone, Ester, additional, Grimaldi, Antonio M., additional, del Zotto, Genny, additional, Gulletta, Elio, additional, Ciliberto, Gennaro, additional, Moretta, Alessandro, additional, Ascierto, Paolo A., additional, Carbone, Ennio, additional, Costantini, Susan, additional, Sorice, Angela, additional, Capone, Francesca, additional, Budillon, Alfredo, additional, Cauchi, Carolina, additional, Sciancalepore, Grazia, additional, Rovera, Michela, additional, Varamo, Chiara, additional, Seia, Zelda, additional, Palazzini, Stefania, additional, Errico, Fabiana, additional, Basso, Davide, additional, Quaranta, Laura, additional, Forte, Giuseppe, additional, Lavagna, Fulvio, additional, Violante, Silvia, additional, Bosio, Paolo, additional, Lattanzio, Laura, additional, Merlano, Marco C, additional, Gowen, Mike, additional, Tchack, Jeremy, additional, Zhou, Hua, additional, Giles, Keith, additional, Paschke, Scott, additional, Moran, Una, additional, Fenyo, David, additional, Tsirigos, Aris, additional, Pacold, Michael, additional, Morello, Silvana, additional, Sorrentino, Claudia, additional, Giannarelli, Diana, additional, Pinto, Aldo, additional, Fratangelo, Federica, additional, Falcone, Rosaria, additional, Vanella, Vito, additional, Schadendorf, Dirk, additional, Lewis, Karl, additional, Maio, Michele, additional, Demidov, Lev, additional, Mandalà, Mario, additional, Bondarenko, Igor, additional, Herbert, Christopher, additional, Mackiewicz, Andrzej, additional, Rutkowski, Piotr, additional, Guminski, Alexander, additional, Goodman, Grant, additional, Simmons, Brian, additional, Ye, Chenglin, additional, Hooper, Gregory, additional, Wongchenko, Matthew J., additional, Yan, Yibing, additional, Hermann, Frank, additional, Ammendola, Astrid, additional, Bartz, René, additional, Alessandra, Bulotta, additional, Letizia, Colombo, additional, Aurora, Mirabile, additional, Chiara, Lazzari, additional, Raffaele, Mercuri Santo, additional, Danilo, Parolini, additional, Nathalie, Rizzo, additional, Stefano, Martella, additional, Giulio, Modorati, additional, Pina, Brianti, additional, Enza, Cestone, additional, Federica, Bellinzona, additional, Elisabetta, Miserocchi, additional, Luca, Gianni, additional, Vanesa, Gregorc, additional, Agarwala, Sanjiv, additional, Mark Smithers, B., additional, Haushild, Axel, additional, Watcher, Eric, additional, Fattore, Luigi, additional, Ruggiero, Ciro Francesco, additional, Liguoro, Domenico, additional, Cerri, Andrea, additional, Pisanu, Maria Elena, additional, and Mancini, Rita, additional

Published
2018
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12. Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society Recommendations.

Author

Low, Donald E., Allum, William, De Manzoni, Giovanni, Ferri, Lorenzo, Immanuel, Arul, Kuppusamy, MadhanKumar, Law, Simon, Lindblad, Mats, Maynard, Nick, Neal, Joseph, Pramesh, C. S., Scott, Mike, Mark Smithers, B., Addor, Valérie, and Ljungqvist, Olle

Subjects
SURGERY, ESOPHAGECTOMY, SURGICAL excision, ESOPHAGEAL cancer, MORTALITY
Abstract

Introduction: Enhanced recovery after surgery (ERAS) programs provide a format for multidisciplinary care and has been shown to predictably improve short term outcomes associated with surgical procedures. Esophagectomy has historically been associated with significant levels of morbidity and mortality and as a result routine application and audit of ERAS guidelines specifically designed for esophageal resection has significant potential to improve outcomes associated with this complex procedure.Methods: A team of international experts in the surgical management of esophageal cancer was assembled and the existing literature was identified and reviewed prior to the production of the guidelines. Well established procedure specific components of ERAS were reviewed and updated with changes relevant to esophagectomy. Procedure specific, operative and technical sections were produced utilizing the best current level of evidence. All sections were rated regarding the level of evidence and overall recommendation according to the evaluation (GRADE) system.Results: Thirty-nine sections were ultimately produced and assessed for quality of evidence and recommendations. Some sections were completely new to ERAS programs due to the fact that esophagectomy is the first guideline with a thoracic component to the procedure.Conclusions: The current ERAS society guidelines should be reviewed and applied in all centers looking to improve outcomes and quality associated with esophageal resection. [ABSTRACT FROM AUTHOR]

Published
2019
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15. A combined modality approach to the management of oesophageal cancer

Author

Mark Smithers, B., primary, Devitt, Peter, additional, Jamieson, Glyn G., additional, Bessell, Justin, additional, Gotley, David, additional, Grantley Gill, P., additional, Neely, Mervyn, additional, Joseph, David J., additional, Yeoh, Eric K., additional, Burmeister, Bryan, additional, and Denham, James W., additional

Published
1997
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16. Feasibility of chemoradiation therapy with protracted infusion of 5-fluorouracil for esophageal cancer patients not suitable for cisplatin.

Author

Burmeister BH, Walpole ET, Burmeister EA, Thomas J, Thomson DB, Harvey JA, Mark Smithers B, and Gotley DC

Subjects
Adenocarcinoma drug therapy, Adenocarcinoma radiotherapy, Adenocarcinoma secondary, Aged, Aged, 80 and over, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell radiotherapy, Carcinoma, Squamous Cell secondary, Combined Modality Therapy, Drug Administration Schedule, Esophageal Neoplasms pathology, Feasibility Studies, Female, Humans, Lymphatic Metastasis prevention & control, Male, Middle Aged, Quality of Life, Survival Rate, Antimetabolites, Antineoplastic therapeutic use, Esophageal Neoplasms drug therapy, Esophageal Neoplasms radiotherapy, Fluorouracil therapeutic use, Salvage Therapy
Abstract

Background: Chemoradiation therapy is the standard treatment for esophageal cancer in patients not fit for surgery. The regimen most commonly used includes cisplatin and 5-fluorouracil. Little data exists regarding alternative chemotherapy regimens in patients not suitable for cisplatin. We report on a regimen using protracted infusion 5-fluorouracil alone for both curative and palliative indications., Methods: Twenty-two patients with localized esophageal cancer suitable for curative chemoradiation therapy and 24 patients suitable for palliative therapy were enrolled. Chemotherapy consisted of 5-fluorouracil 225 mg/m(2) daily throughout the radiation therapy. The radiation dose was 56 to 60 Gy in 28 to 30 fractions (curative patients) and 30 to 35 Gy in 15 fractions (palliative patients)., Results: The median age of the patients was 75 years. The regimen was tolerable. Significant grade 3 toxicities experienced were esophagitis (11%) and venous catheter toxicity (9%). The median survival was 17 months for curative patients and 9 months for palliative patients. The complete response rate was 86% endoscopically and 45% radiologically for curative patients. Relief of dysphagia was experienced in 67% of palliative patients. Quality of life was satisfactory in both groups., Conclusions: This study showed that continuous-infusion 5-fluorouracil given concurrently with radiation therapy is a useful alternative to platinum-based chemoradiation therapy in patients with esophageal carcinoma.

Published
2005
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