792 results on '"Mark D. Miller"'
Search Results
2. No Deficits in Functional Outcomes of the Contralateral Limb Are Seen When the Hamstring Is Harvested for Augmentation of Small Diameter Ipsilateral Hamstring Autograft
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Thomas E. Moran, M.D., Pradip Ramamurti, M.D., Douglas K. Wells, M.D., Xavier Thompson, A.T.C., Joseph M. Hart, Ph.D., David R. Diduch, M.D., Stephen F. Brockmeier, M.D., Mark D. Miller, M.D., Winston F. Gwathmey, M.D., and Brian C. Werner, M.D.
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Sports medicine ,RC1200-1245 - Abstract
Purpose: To evaluate clinical outcomes of the contralateral, nonoperative limb in patients undergoing contralateral hamstring (HS) autograft harvest compared with patients undergoing ipsilateral HS autograft harvest alone. Methods: This study included 96 patients who underwent isolated anterior cruciate ligament reconstruction (ACLR) using 4-stranded HS autograft (n = 85) or 4-stranded HS autograft augmented with contralateral HS (n = 13) due to inclusion of ipsilateral graft diameter
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- 2023
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3. Potential impacts of synthetic food dyes on activity and attention in children: a review of the human and animal evidence
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Mark D. Miller, Craig Steinmaus, Mari S. Golub, Rosemary Castorina, Ruwan Thilakartne, Asa Bradman, and Melanie A. Marty
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Synthetic food dyes ,Children ,Behavior ,Clinical trials ,Animal toxicology ,Industrial medicine. Industrial hygiene ,RC963-969 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Concern that synthetic food dyes may impact behavior in children prompted a review by the California Office of Environmental Health Hazard Assessment (OEHHA). OEHHA conducted a systematic review of the epidemiologic research on synthetic food dyes and neurobehavioral outcomes in children with or without identified behavioral disorders (particularly attention and activity). We also conducted a search of the animal toxicology literature to identify studies of neurobehavioral effects in laboratory animals exposed to synthetic food dyes. Finally, we conducted a hazard characterization of the potential neurobehavioral impacts of food dye consumption. We identified 27 clinical trials of children exposed to synthetic food dyes in this review, of which 25 were challenge studies. All studies used a cross-over design and most were double blinded and the cross-over design was randomized. Sixteen (64%) out of 25 challenge studies identified some evidence of a positive association, and in 13 (52%) the association was statistically significant. These studies support a relationship between food dye exposure and adverse behavioral outcomes in children. Animal toxicology literature provides additional support for effects on behavior. Together, the human clinical trials and animal toxicology literature support an association between synthetic food dyes and behavioral impacts in children. The current Food and Drug Administration (FDA) acceptable daily intakes are based on older studies that were not designed to assess the types of behavioral effects observed in children. For four dyes where adequate dose-response data from animal and human studies were available, comparisons of the effective doses in studies that measured behavioral or brain effects following exposure to synthetic food dyes indicate that the basis of the ADIs may not be adequate to protect neurobehavior in susceptible children. There is a need to re-evaluate exposure in children and for additional research to provide a more complete database for establishing ADIs protective of neurobehavioral effects.
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- 2022
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4. Lateral Extra-Articular Tenodesis Staple Risks Penetration of Anterior Cruciate Ligament Reconstruction Tunnel
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Thomas E. Moran, M.D., Ian S. MacLean, M.D., Gregory R. Anderson, M.D., Laurel A. Barras, M.D., Ryan M. Graf, M.D., David R. Diduch, M.D., and Mark D. Miller, M.D.
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Sports medicine ,RC1200-1245 - Abstract
Purpose: To identify the risk of anterior cruciate ligament (ACL) femoral tunnel penetration with the use of a staple for lateral extra-articular tenodesis (LET) graft fixation and to determine whether this varied between 2 different techniques for ACL femoral tunnel drilling. Methods: Twenty paired, fresh-frozen, cadaver knees underwent ACL reconstruction with a LET. Left and right knees were randomized to ACL reconstruction with femoral tunnel creation by use of either a rigid guide pin and reamer through the accessory anteromedial portal or by the use of a flexible guide pin and reamer through the anteromedial portal. Immediately after tunnel creation, the LET was performed and fixated with a small Richard’s staple. Fluoroscopy was used to obtain a lateral view of the knee to determine staple position, and visualization of the ACL femoral tunnel was performed with the arthroscope to investigate penetration of the staple into the femoral tunnel. The Fisher exact test was conducted to determine whether there was any difference in tunnel penetration between tunnel creation techniques. Results: The staple was noted to penetrate the ACL femoral tunnel in 8 of 20 (40%) extremities. When stratified by tunnel creation technique, the Richards staple violated 5 of 10 (50%) of the tunnels made via the rigid reaming technique compared with 3 of 10 (30%) of those created with a flexible guide pin and reamer (P = .65). Conclusions: A high incidence of femoral tunnel violation is seen with lateral extra-articular tenodesis staple fixation. Level of Evidence: Level IV, controlled laboratory study. Clinical Relevance: The risk of penetrating the ACL femoral tunnel with a staple for LET graft fixation is not well understood. Yet, the integrity of the femoral tunnel is important for the success of ACL reconstruction. Surgeons can use the information in this study to consider adjustments to operative technique, sequence, or fixation devices used when performing ACL reconstruction with concomitant LET to avoid the potential for disruption of ACL graft fixation.
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- 2023
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5. Dataset of FD&C Certified Food Dyes in Foods Commonly Consumed by Children
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Arlie L. Lehmkuhler, Mark D. Miller, Asa Bradman, Rosemary Castorina, Mary-Ann Chen, Tonya Xie, and Alyson E. Mitchell
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FD&C dyes ,Food samples ,Estimated dietary intake ,High performance liquid chromatography ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
This is dataset describing the levels of Food, Drug, & Cosmetic (FD&C) dye in juice drinks, breakfast cereals, frozen desserts, ice cream cones, fruit flavored soft drinks, frostings & icings, fruit snacks/candy, decoration chips for baking, water enhancers, and flavored fruit drink powder. Data values are organized by absolute values, averages, SDs and % RSD. High performance liquid chromatography with a photometric diode array detector (HPLC-PDA) was used to measure dye levels and generate the data. These values can be used to calculate levels of dyes consumed within various populations, such as children, and compare them to accepted daily intake (ADIs) values established by the United States Food & Drug Administration (US FDA). The data are interpreted in “Survey of Certified Food Dye Levels in Food Samples Consumed by Children for Updated Exposure Levels” in the Journal of Food Additives and Contaminants: Part B.1
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- 2023
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6. Developing and implementing core competencies in children’s environmental health for students, trainees and healthcare providers: a narrative review
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Rose Hannah Goldman, Lauren Zajac, Robert J. Geller, and Mark D. Miller
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Environmental health ,Pediatric environmental health ,Health disparities ,Climate change ,Medical education ,Competencies ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Knowledge of the health impacts of environmental exposures (such as pollution disasters, poor air quality, water contamination, climate change) on children’s health has dramatically increased in the past 40 years. The World Health Organization (WHO) estimated that 23% of all deaths worldwide were attributable to the environment, and 26% of deaths in children less than 5 years old could be prevented with removal of environmental risks factors. Yet, little has permeated medical education, leaving pediatric providers ill equipped to address these issues. To address this gap, members from the Pediatric Environmental Health Specialty Units, a United States nationwide network of academically affiliated experts who have created numerous environmental health educational materials and programs, have identified fifteen core environmental health (EH) competencies needed by health care providers to enable them to effectively address environmental health concerns. These competencies can serve as the foundation for the development and implementation of relevant educational programs. The core EH competencies are based upon these foundational elements: 1) Definition of “children’s environmental health” that describes how environmental exposures (positive and negative) in early life influence the health and development in childhood and across the entire human life span 2) Children are not “little adults” and so have unique vulnerabilities to environmental hazards; 3) Environmental health inequities exist, causing some children to have a disproportionate amount of unhealthy exposures and consequently a greater risk of adverse effects; 4) Climate change will translate to numerous adverse health effects that will particularly affect children worldwide. In this article, the authors describe the core environmental health competencies and provide resources, online tools, strategies, and examples targeted to all levels of training and practice to better enable leaders and educators to bring this important content to the forefront.
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- 2021
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7. All-Inside Meniscal Repair: A Historical View
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Ian S. MacLean MD and Mark D. Miller MD
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Sports medicine ,RC1200-1245 ,Orthopedic surgery ,RD701-811 - Abstract
Background: All-inside meniscal repair first became popularized in the early 2000s. Since that time, there has been a wide variety of all-inside implants on the market with rapid changes and developments in recent years. Indications: Small, peripheral, longitudinal tears are best suited for all-inside repair, but this technique may even be used for large bucket handle tears especially when hybridized with an inside-out repair. Technique Description: A percutaneous release of the medial collateral ligament (MCL) with an 18-g spinal needle is frequently performed when working in the medial compartment to improve visualization and decrease risk of iatrogenic chondral injury. Close familiarity with the characteristics of the chosen all-inside device including device angle, modifiability of device angle, modifiability of needle depth, deployment method, and tensioning technique is important for obtaining reproducible results. Typically, obtaining a vertical mattress stitch configuration is optimal as it captures more circumferential collagen fibers in the repair. Results: Factors to consider when selecting an all-inside meniscal repair device include the ergonomics of the device, implant cost, availability, rigid versus suture-based anchor, core needle diameter, device flexibility, and percent of misfires. Discussion: Complications from use of all-inside meniscus repair devices include device failure, soft tissue entrapment, cyst formation, and injury to the popliteal artery. Outcomes, however, with current devices are good and comparable to inside-out meniscus repair with about a 90% return to sports rate at 12 months postoperatively. The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
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- 2022
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8. Varus collapse following anterior closing wedge proximal tibial osteotomy for ACL revision reconstruction: a case series
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Ian S. MacLean, William A. Tyndall, Robert C. Schenck, and Mark D. Miller
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ACL ,Revision ,Posterior tibial slope ,Proximal tibial osteotomy ,Slope correcting osteotomy ,varus collapse ,Orthopedic surgery ,RD701-811 - Abstract
Abstract A slope‐correcting anterior closing wedge proximal tibial osteotomy is a powerful tool for correcting increased posterior tibial slope in the setting of a failed anterior cruciate ligament reconstruction. This case series documents three cases in which patients collapsed into varus following an anterior closing wedge proximal tibia osteotomy. Two patients had osteotomies fixated with a “suture‐staple” construct, and all had medical comorbidities or reported noncompliance post‐operatively. Therefore, meticulous care during the planning, execution, and rehabilitation phases is critical as multiple factors throughout the arc of care may contribute towards anterior closing wedge proximal tibial osteotomy varus collapse. Careful optimization of medical comorbidities and rigid fixation with either a plate and screws or compression staples should be used rather than a “suture‐staple” to mitigate this risk. Level of evidence: IV.
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- 2022
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9. Prevalence, Biomechanics, and Pathologies of the Meniscofemoral Ligaments: A Systematic Review
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David G. Deckey, M.D., Sailesh Tummala, M.D., Jens T. Verhey, B.S., Jeffrey D. Hassebrock, M.D., Donald Dulle, M.S., P.A.-C., Mark D. Miller, M.D., and Anikar Chhabra, M.D.
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Sports medicine ,RC1200-1245 - Abstract
Purpose: To systematically review the literature to examine current understanding of the meniscofemoral ligaments (MFLs), their function, their importance in clinical management, and known anatomical variants. Methods: A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using PubMed, EMBASE, and Cochrane databases. Studies were included if they reported on the biomechanical, radiographic, or arthroscopic evaluation of human MFLs, or if they reported on an anatomical variant. These were then categorized as cadaveric, radiographic, or clinical. Biomechanical, radiographic, patient-reported, and functional outcomes data were recorded. Results: Forty-seven studies were included in the qualitative analysis, and 26 of them were included in the quantitative analysis. Of these, there were 15 cadaveric, 3 arthroscopic, and 9 radiographic studies that reported on the prevalence of MFLs. Overall, when looking at all modalities, the presence of either the anterior or posterior MFL (aMFL, pMFL) has been noted to be 70.8%, with it being the aMFL 17.4% and the pMFL 40.6%. The presence of both ligaments occurs in approximately 17.6% of individuals. Eleven reported on mean MFL length and thickness. When evaluating mean length in both men and women, the aMFL has been reported between 21.6 and 28.3 mm and the pMFL length in this population is between 23.4 and 31.2 mm. Five reported on cross-sectional area. Nine additional papers report anatomical variants. Conclusions: This review shows that there continues to be a variable incidence of MFLs reported in the literature, but our understanding of their function continues to broaden. A growing number of anatomic and biomechanical studies have demonstrated the importance of the MFLs in supporting knee stability. Specifically, the MFLs serve an important role in protecting the lateral meniscus and augmenting the function of the posterior cruciate ligament. Clinical Relevance: Our findings will aid the clinician in both identifying and treating pathologies of the meniscofemoral ligaments.
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- 2021
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10. Percutaneous Medial Collateral Ligament Release Improves Medial Compartment Access During Knee Arthroscopy
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Thomas E. Moran, M.D., Alex J. Demers, B.S., Kaitlyn M. Shank, Ed.A.T.C., John T. Awowale, M.D., and Mark D. Miller, M.D.
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Sports medicine ,RC1200-1245 - Abstract
Purpose: To quantify intraoperative joint space widening afforded by the outside-in, percutaneous release of the medial collateral ligament (MCL) and to evaluate its impact on medial compartment width and functional outcomes at 6-week follow-up for patients undergoing a partial medial meniscectomy without postoperative bracing. Methods: Patients with posteromedial meniscus tears and no evidence of ipsilateral knee pathology, undergoing partial medial meniscectomy, were enrolled. Intraoperatively, medial compartment width was quantified with fluoroscopy before and after the percutaneous MCL release with an 18-gauge spinal needle proximal to the joint line. At 6-week follow-up, valgus stress radiographs re-evaluated medial compartment width. International Knee Documentation Committee (IKDC) and Patient-Reported Outcomes Measurement Information System (PROMIS) scores were completed preoperatively and at 6-week follow-up to evaluate functional outcomes. A paired sample t test performed at a 95% confidence interval (CI) was used to compare these variables. Results: Forty-two patients, mean (± standard deviation) age 55.3 ± 10.7 years, were available for analysis of intraoperative medial compartment widening. Medial compartment width increased from 5.95 ± 1.32 to 11.09 ± 1.74 mm intraoperatively after MCL release. At 6-week follow-up, radiographic assessment demonstrated a mean medial compartment width of 5.85 ± .99 mm, which represented an insignificant change compared with the preoperative value (CI –0.68 to .33, P = .474). PROMIS and IKDC scores significantly improved from baseline, with increases of 6.9 ± 12.4 (CI 2.0 to 11.8, P = .008) and 11.7 ± 17.8 (CI 4.7 to 18.8, P = .002), respectively. Conclusions: Percutaneous MCL release during knee arthroscopy improves visualization and facilitates instrumentation by providing an almost 2× wider working space within the medial tibiofemoral joint. In this study, the performance of percutaneous MCL release did not result in any complications. Radiographic and clinical resolution of iatrogenic laxity was demonstrated by 6-weeks postoperatively, without the use of postoperative bracing. Level of Evidence: IV, therapeutic case series.
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- 2021
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11. Dataset of certified food dye levels in over the counter medicines and vitamins intended for consumption by children and pregnant women
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Arlie L. Lehmkuhler, Mark D. Miller, Asa Bradman, Rosemary Castorina, and Alyson E. Mitchell
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FD&C dyes ,Vitamins ,Over the counter medications ,High performance liquid chromatography ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
Food, Drug, & Cosmetic (FD&C) dyes can be found in various products outside of food that are consumed by children. The amount of FD&C dyes used in commercial products is proprietary. Determining the contribution of dye intake from commercial products requires direct assessment of FD&C dyes in the products. This dataset contains the raw data of HPLC peak areas, absolute values, averages, SDs and % RSD for FD&C dyes in children's gummy vitamins, children's tablet vitamins, prenatal vitamins, children's cough/cold/allergy tablets & syrups, and children's pain reliever tablets & syrups obtained using high performance liquid chromatography with a photometric diode array detector (HPLC-PDA). The data can be used for further interpretations of dye intake in children, based upon dose levels suggested for distinct age groups, to evaluate the consumption of the FD&C dyes and accepted daily intake (ADIs) suggested for each FD&C dye by the United States Food & Drug Administration (US FDA). The variability associated within each category is critical for understanding how products on the market can differ between lot especially with large gaps between expiration dates. The interpretation of the data is described in “Certified Food Dyes in Over the Counter Medicines and Supplements Marketed for Children and Pregnant Women” in the Journal of Food and Chemical Toxicology [1].
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- 2020
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12. The Outside-In, Percutaneous Release of the Medial Collateral Ligament for Knee Arthroscopy
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Thomas E. Moran, M.D., Alex Demers, B.S., John T. Awowale, M.D., Brian C. Werner, M.D., and Mark D. Miller, M.D.
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Orthopedic surgery ,RD701-811 - Abstract
The outside-in, percutaneous release of the medial collateral ligament (MCL) is a technique used to increase the medial tibiofemoral joint space during arthroscopy to facilitate the use of instrumentation and improve visualization without causing iatrogenic cartilage damage. A recent systematic review of the literature has shown this technique to be efficacious and safe, with no evidence of associated short- or long-term complications. This technique has been used for this indication by the senior author without requiring any deviation from our institution’s standard protocol for knee arthroscopy. In an attempt to standardize this technique’s utilization and allow for further evaluation in the literature, the senior author’s method for this percutaneous, outside-in approach of “pie crusting” the MCL is described.
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- 2020
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13. Surgical Management of the Multiple-Ligament Knee Injury
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Kadir Buyukdogan, M.D., Michael S. Laidlaw, M.D., and Mark D. Miller, M.D.
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Orthopedic surgery ,RD701-811 - Abstract
The management of multiligament knee injury is a complex process starting with the adequate identification of the injury. A detailed physical and radiographic examination with a thorough understanding of knee anatomy is crucial to assess all damaged structures: anterior cruciate ligament, posterior cruciate ligament, posteromedial corner including the medial collateral ligament, and posterolateral corner including the lateral collateral ligament. Several surgical techniques have been developed throughout the years to adequately address these ligament insufficiencies. In this surgical technique description, we describe a reproducible method for the assessment and surgical management of a knee dislocation (KDIV) injury. Our approach includes using anatomic single-bundle cruciate ligament reconstructions with modified Bosworth technique for medial-side injuries and a combination of Müller popliteal bypass and Larson figure-of-8 techniques for posterolateral corner injuries. The orders of surgical steps is described concisely, and technical controversies such as graft choice, tunnel positioning, and sequence of graft fixation are discussed in detail.
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- 2018
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14. Two-Stage Revision Anterior Cruciate Ligament Reconstruction Using Allograft Bone Dowels
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Kadir Buyukdogan, M.D., Michael S. Laidlaw, M.D., and Mark D. Miller, M.D.
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Orthopedic surgery ,RD701-811 - Abstract
Revision anterior cruciate ligament (ACL) reconstruction is substantially more challenging than primary reconstruction. Management of previously malpositioned or widened tunnels often requires innovative approaches for managing bony defects. Massive osteolysis with poor bone stock and convergence or overlapping of revision tunnels into the previously placed tunnels may necessitate a staged revision procedure. In this surgical technique description, we describe a method for the management of bony deficiencies using allograft bone dowels in staged revision ACL reconstruction.
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- 2017
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15. Meniscal Ramp Lesion Repair by a Trans-septal Portal Technique
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Kadir Buyukdogan, M.D., Michael S. Laidlaw, M.D., and Mark D. Miller, M.D.
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Orthopedic surgery ,RD701-811 - Abstract
The identification of meniscal ramp lesions can be quite difficult or even impossible with conventional anterior arthroscopic viewing and working portals. Although even the use of transnotch viewing maneuvers into the posteromedial compartment increases the likelihood of diagnosis, it is the posteromedial and trans-septal portals that provide the best direct visualization of these many times “hidden lesions.” In this surgical technique description, we describe a method to not only adequately visualize the ramp lesion, but also provide subtle variations to existing surgical techniques that can help limit injury to neurovascular structures as well as gain satisfactory vertical suture repair of this posteromedial meniscocapsular injury.
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- 2017
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16. Clinical and Functional Outcomes following Primary Repair versus Reconstruction of the Medial Patellofemoral Ligament for Recurrent Patellar Instability
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Marc Tompkins, Christopher M. Kuenze, David R. Diduch, Mark D. Miller, Matthew D. Milewski, and Joseph P. Hart
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Sports medicine ,RC1200-1245 - Abstract
Background. The purpose of this study was to compare outcomes of medial patellofemoral ligament (MPFL) repair or reconstruction. Methods. Fourteen knees that underwent MPFL repair and nine (F5, M4) knees that underwent reconstruction at our institution were evaluated for objective and subjective outcomes. The mean age at operation was 20.1 years for repair and 19.8 years for reconstruction. All patients had a minimum of 2 years of follow-up (range: 24–75 months). Patient subjective outcomes were obtained using the International Knee Documentation Committee (IKDC) and Kujala patellofemoral subjective evaluations, as well as Visual Analog (VAS) and Tegner Activity Scales. Bilateral isometric quadriceps strength and vastus medialis obliquus (VMO) and vastus lateralis (VL) surface EMG were measured during maximal isometric quadriceps contractions at 30° and 60° of flexion. Results. There were no redislocations in either group. There was no difference in IKDC (P=0.16), Kujala (P=0.43), Tegner (P=0.12), or VAS (P=0.05) scores at follow-up. There were no differences between repair and reconstruction in torque generation of the involved side at 30° (P=0.96) and 60° (P=0.99). In addition, there was no side to side difference in torque generation or surface EMG activation of VL or VMO. Conclusions. There were minimal differences found between patients undergoing MPFL repair and MPFL reconstruction for the objective and subjective evaluations in this study.
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- 2014
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17. Treatment of a Patellar Chondral Defect Using Juvenile Articular Cartilage Allograft Implantation
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Justin W. Griffin, M.D., C. Jan Gilmore, M.D., and Mark D. Miller, M.D.
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Orthopedic surgery ,RD701-811 - Abstract
Focal articular cartilage defects of the knee commonly occur. Various arthroscopic and open procedures have been developed to address these lesions when they are symptomatic, all aimed at defect filling. Juvenile cartilage transplantation procedures have recently been described as an option for managing symptomatic cartilage lesions. We present a technique using transfer of juvenile cartilage allograft transplantation into the defect with subsequent second-look arthroscopy and biopsy results after implantation.
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- 2013
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18. Influence of interim functional assessments on patient outcomes at the time of return to activity following ACL-reconstruction
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Stephan G. Bodkin, Amelia S. Bruce, Brian C. Werner, David R. Diduch, Stephen F. Brockmeier, Mark D. Miller, F. Winston Gwathmey, and Joe M. Hart
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Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,General Medicine - Published
- 2023
19. Coaching in Sports Medicine
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F. Winston Gwathmey and Mark D. Miller
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Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Published
- 2023
20. Predicting Anterior Cruciate Ligament Reinjury From Return-to-Activity Assessments at 6 Months Postsurgery: A Prospective Cohort Study
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Mark D. Miller, Stephan G. Bodkin, Frank W. Gwathmey, David R. Diduch, Susan A. Saliba, Brian C. Werner, Jay Hertel, Wendy M. Novicoff, Stephen F. Brockmeier, and Joseph M. Hart
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Male ,medicine.medical_specialty ,Quadriceps strength ,Physical Therapy, Sports Therapy and Rehabilitation ,Context (language use) ,Post surgery ,Quadriceps Muscle ,medicine ,Humans ,Orthopedics and Sports Medicine ,In patient ,Knee ,Muscle Strength ,Prospective Studies ,Anterior Cruciate Ligament ,Prospective cohort study ,Reinjuries ,business.industry ,Anterior Cruciate Ligament Injuries ,Return to activity ,General Medicine ,medicine.disease ,ACL injury ,Return to Sport ,Physical therapy ,Female ,business ,Knee flexor - Abstract
Context Return-to-activity (RTA) assessments are commonly administered after anterior cruciate ligament reconstruction (ACLR) to manage the patient's postoperative progressions back to activity. To date, few data are available on the clinical utility of these assessments to predict patient outcomes such as secondary anterior cruciate ligament (ACL) injury once the athlete has returned to activity. Objective To identify the measures of patient function at 6 months post-ACLR that best predict RTA and second ACL injury at a minimum of 2 years after ACLR. Design Prospective cohort study. Setting Laboratory. Patients or Other Participants A total of 234 patients with primary, unilateral ACLR completed functional assessments at approximately 6 months post-ACLR. Of these, 192 (82.1%) completed follow-up at ≥2 years post-ACLR. Main Outcome Measure(s) The 6-month functional assessments consisted of patient-reported outcomes, isokinetic knee-flexor and -extensor strength, and single-legged hopping. We collected RTA and secondary ACL injury data at ≥2 years after ACLR. Results Of the patients who were able to RTA (n = 155), 44 (28.4%) had a subsequent ACL injury, 24 (15.5%) to the ipsilateral graft ACL and 20 (12.9%) to the contralateral ACL. A greater proportion of females had a secondary injury to the contralateral ACL (15/24, 62.5%), whereas a greater proportion of males reinjured the ipsilateral ACL graft (15/20, 75.0%; P = .017). Greater knee-extension symmetry at 6 months increased the probability of reinjury (B = 0.016, P = .048). Among patients with RTA at 8 months, every month that RTA was delayed reduced the risk of reinjury by 28.4% (B = –0.284, P = .042). Descriptive statistics of patient function stratified between the early and delayed RTA groups can be found in the Supplemental Table (available online at http://dx.doi.org/10.4085/1062-6050-0407.20.S1). Conclusions Patients with more symmetric quadriceps strength at 6 months post-ACLR were more likely to experience another ACL rupture, especially those who returned to sport at
- Published
- 2023
21. Hours of Boredom, Punctuated by Moments of Sheer Terror
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Mark D. Miller
- Subjects
Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Published
- 2023
22. Vascular Complications in Sports Surgery: Diagnosis and Management
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Scott E. Dart, Greg R. Anderson, Mark D. Miller, and Brian C. Werner
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Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Published
- 2022
23. Put Me in Coach!
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Mark D. Miller
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Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Published
- 2023
24. Prevalence, Biomechanics, and Pathologies of the Meniscofemoral Ligaments: A Systematic Review
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Mark D. Miller, Jens T. Verhey, David G. Deckey, Donald L. Dulle, Anikar Chhabra, Jeffrey D. Hassebrock, and Sailesh V. Tummala
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Lateral meniscus ,Orthodontics ,education.field_of_study ,business.industry ,Radiography ,Rehabilitation ,Population ,Public Health, Environmental and Occupational Health ,Biomechanics ,Physical Therapy, Sports Therapy and Rehabilitation ,Systematic review ,medicine.anatomical_structure ,Posterior cruciate ligament ,Sports medicine ,medicine ,Orthopedics and Sports Medicine ,Clinical significance ,Systematic Review ,Cadaveric spasm ,education ,business ,RC1200-1245 - Abstract
Purpose To systematically review the literature to examine current understanding of the meniscofemoral ligaments (MFLs), their function, their importance in clinical management, and known anatomical variants. Methods A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using PubMed, EMBASE, and Cochrane databases. Studies were included if they reported on the biomechanical, radiographic, or arthroscopic evaluation of human MFLs, or if they reported on an anatomical variant. These were then categorized as cadaveric, radiographic, or clinical. Biomechanical, radiographic, patient-reported, and functional outcomes data were recorded. Results Forty-seven studies were included in the qualitative analysis, and 26 of them were included in the quantitative analysis. Of these, there were 15 cadaveric, 3 arthroscopic, and 9 radiographic studies that reported on the prevalence of MFLs. Overall, when looking at all modalities, the presence of either the anterior or posterior MFL (aMFL, pMFL) has been noted to be 70.8%, with it being the aMFL 17.4% and the pMFL 40.6%. The presence of both ligaments occurs in approximately 17.6% of individuals. Eleven reported on mean MFL length and thickness. When evaluating mean length in both men and women, the aMFL has been reported between 21.6 and 28.3 mm and the pMFL length in this population is between 23.4 and 31.2 mm. Five reported on cross-sectional area. Nine additional papers report anatomical variants. Conclusions This review shows that there continues to be a variable incidence of MFLs reported in the literature, but our understanding of their function continues to broaden. A growing number of anatomic and biomechanical studies have demonstrated the importance of the MFLs in supporting knee stability. Specifically, the MFLs serve an important role in protecting the lateral meniscus and augmenting the function of the posterior cruciate ligament. Clinical Relevance Our findings will aid the clinician in both identifying and treating pathologies of the meniscofemoral ligaments.
- Published
- 2021
25. A novel meniscofemoral ligament variant intra-substance to the PCL
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Sailesh V. Tummala, Donald L. Dulle, Jeremiah R. Long, Mark D. Miller, Jeffrey D. Hassebrock, David G. Deckey, Jens T. Verhey, and Anikar Chhabra
- Subjects
Lateral meniscus ,medicine.medical_specialty ,Anterior meniscofemoral ligament ,business.industry ,Posterior meniscofemoral ligament ,Biomechanics ,Anatomy ,musculoskeletal system ,medicine.anatomical_structure ,Posterior cruciate ligament ,Orthopedic surgery ,medicine ,Orthopedics and Sports Medicine ,Surgery ,Meniscofemoral ligament ,business - Abstract
While much detail is known about each anatomic structure of the knee and its contributory effect on biomechanics, our understanding is still evolving. In particular, the function of the meniscofemoral ligaments and their anatomical variants have yet to be fully described. In this report, a never-before-described anatomical meniscofemoral ligament variant intra-substance to the PCL is presented. Arthroscopists should be aware of the novel variant as a growing number of studies have demonstrated the biomechanical importance of the meniscofemoral ligaments in protecting the lateral meniscus and supporting the function of the PCL. Level of Evidence: IV.
- Published
- 2021
26. Pediatric and Adolescent Knee Injuries: The PRiSM Vision
- Author
-
Mark D. Miller
- Subjects
Adolescent ,Risk Factors ,Humans ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,Knee Injuries ,Child - Published
- 2022
27. The Evolution of Treatment for Rotator Cuff Tears
- Author
-
Mark D, Miller
- Subjects
Rotator Cuff ,Arthroscopy ,Humans ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,Rotator Cuff Injuries - Published
- 2023
28. Comparison of Patient-Reported Outcomes, Strength, and Functional Performance in Primary Versus Revision Anterior Cruciate Ligament Reconstruction
- Author
-
Madison D. Sroufe, Anna E. Sumpter, Xavier D. Thompson, Thomas E. Moran, Amelia S. Bruce Leicht, David R. Diduch, Stephen F. Brockmeier, Mark D. Miller, F. Winston Gwathmey, Brian C. Werner, Brian Pietrosimone, and Joe M. Hart
- Subjects
Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Abstract
Background: Clinical outcomes after revision anterior cruciate ligament reconstruction (ACLR) are not well understood. Hypothesis: Patients undergoing revision ACLR would demonstrate worse patient-reported outcomes and worse limb symmetry compared with a cohort undergoing primary ACLR. Study Design: Cohort study; Level of evidence, 3. Methods: 672 participants (373 with primary ACLR, 111 with revision ACLR, and 188 uninjured) completed functional testing at a single academic medical center. Descriptive information, operative variables, and patient-reported outcomes (International Knee Documentation Committee score, Knee injury and Osteoarthritis Outcome Score, and Tegner Activity Scale score) were assessed for each patient. Quadriceps and hamstring strength tests were conducted using a Biodex System 3 Dynamometer. Single-leg hop for distance, triple hop test, and the 6-m timed hop test were also assessed. Limb symmetry index (LSI) between the ACLR limb and contralateral limb was calculated for strength and hop testing. Normalized peak torque (N·m/kg) was calculated for strength testing. Results: No differences were found in group characteristics, excluding body mass ( P < .001), or in patient-reported outcomes. There were no interactions between revision status, graft type, and sex. Knee extension LSI was inferior ( P < .001) in participants who had undergone primary (73.0% ± 15.0%) and revision (77.2% ± 19.1%) ACLR compared with healthy, uninjured participants (98.8% ± 10.4%). Knee flexion LSI was inferior ( P = .04) in the primary group (97.4% ± 18.4%) compared with the revision group (101.9% ± 18.5%). Difference in knee flexion LSI between the uninjured and primary groups, as well as between the uninjured and revision groups, did not reach statistical significance. Hop LSI outcomes were significantly different across all groups ( P < .001). Between-group differences in extension in the involved limb ( P < .001) were noted, as the uninjured group exhibited stronger knee extension (2.16 ± 0.46 N·m/kg) than the primary group (1.67 ± 0.47 N·m/kg) and the revision group (1.78 ± 0.48 N·m/kg). As well, differences in flexion in the involved limb ( P = .01) were found, as the revision group exhibited stronger knee flexion (1.06 ± 0.25 N·m/kg) than the primary group (0.97 ± 0.29 N·m/kg) and the uninjured group (0.98 ± 0.24 N·m/kg). Conclusion: At 7 months postoperatively, patients who had undergone revision ACLR did not demonstrate inferior patient-reported outcomes, limb symmetry, strength, or functional performance compared with patients who had undergone primary ACLR. Patients who had undergone revision ACLR exhibited greater strength and LSI than their counterparts with primary ACLR, but these parameters were still inferior to those of uninjured controls.
- Published
- 2023
29. Anterior Cruciate Ligament Revision Reconstruction
- Author
-
Courtney A Quinn, Michelle E. Kew, and Mark D. Miller
- Subjects
Reoperation ,medicine.medical_specialty ,Osteolysis ,Anterior cruciate ligament ,medicine.medical_treatment ,Physical examination ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Orthopedics and Sports Medicine ,In patient ,Recurrent instability ,Anterior Cruciate Ligament ,Physical Examination ,030222 orthopedics ,Rehabilitation ,Anterior Cruciate Ligament Reconstruction ,medicine.diagnostic_test ,business.industry ,Anterior Cruciate Ligament Injuries ,030229 sport sciences ,medicine.disease ,Surgery ,Young age ,medicine.anatomical_structure ,Bone tunnel ,business - Abstract
Revision anterior cruciate ligament (ACL) reconstruction is used in patients with recurrent instability after primary ACL reconstruction. Identifying the etiology of graft failure is critical to the success of revision reconstruction. The most common etiologies include technical errors, trauma, failure to recognize concomitant injuries, young age, incomplete rehabilitation, and hardware failure. Patients should undergo a complete history and physical examination with a specific focus on previous injury mechanism and surgical procedures. A revision ACL reconstruction is a technically demanding procedure, and the surgeon should be prepared to address bone tunnel osteolysis, concurrent meniscal, ligamentous, or cartilage lesions, and limb malalignment. Surgical techniques described in this article include both single-stage and two-stage reconstruction procedures. Rates of return to sport after a revision reconstruction are lower than after primary reconstruction. Future research should be focused on improving both single-stage and two-stage revision techniques, as well as concomitant procedures to address limb malalignment and associated injuries.
- Published
- 2021
30. Effect of Tibial Tunnel Placement Using the Lateral Meniscus as a Landmark on Clinical Outcomes of Anatomic Single-Bundle Anterior Cruciate Ligament Reconstruction
- Author
-
Mark D. Miller, Kadir Buyukdogan, Michael S. Laidlaw, Michael A. Fox, and Michelle E. Kew
- Subjects
Knee Joint ,Anterior cruciate ligament reconstruction ,medicine.medical_treatment ,Anterior cruciate ligament ,Physical Therapy, Sports Therapy and Rehabilitation ,Anterior horn ,Menisci, Tibial ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Double bundle ,medicine ,Humans ,Fluoroscopy ,Orthopedics and Sports Medicine ,Anterior Cruciate Ligament ,Retrospective Studies ,Lateral meniscus ,030222 orthopedics ,Landmark ,Anterior Cruciate Ligament Reconstruction ,Tibia ,medicine.diagnostic_test ,business.industry ,Tibial tunnel ,Anterior Cruciate Ligament Injuries ,030229 sport sciences ,Anatomy ,musculoskeletal system ,Treatment Outcome ,medicine.anatomical_structure ,business - Abstract
Background: It remains unclear if use of the lateral meniscus anterior horn (LMAH) as a landmark will produce consistent tunnel positions in the anteroposterior (AP) distance across the tibial plateau. Purpose: To evaluate the AP location of anterior cruciate ligament (ACL) reconstruction tibial tunnels utilizing the LMAH as an intra-articular landmark and to examine how tunnel placement affects knee stability and clinical outcomes. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective review was conducted of 98 patients who underwent primary ACL reconstruction with quadrupled hamstring tendon autografts between March 2013 and June 2017. Patients with unilateral ACL injuries and a minimum follow-up of 2 years were included in the study. All guide pins for the tibial tunnel were placed using the posterior border of the LMAH as an intra-articular landmark. Guide pins were evaluated with the Bernard-Hertel grid in the femur and the Stäubli-Rauschning method in the tibia. Patients were divided by the radiographic location of the articular entry point of the guide pin with relation to the anterior 40% of the tibial plateau. Outcomes were evaluated by the Marx Activity Scale and International Knee Documentation Committee (IKDC) form. Anterior knee laxity was evaluated using a KT-1000 arthrometer and graded with the objective portion of the IKDC form. Rotational stability was evaluated using the pivot-shift test. Results: A total of 60 patients were available for follow-up at a mean 28.6 months. The overall percentage of AP placement of the tibial tunnel was 39.3% ± 3.8% (mean ± SD; range, 31%-47%). Side-to-side difference of anterior knee laxity was significantly lower in the anterior group than the posterior group (1.2 ± 1.1 mm vs 2.5 ± 1.3 mm; P < .001; r = 0.51). The percentage of AP placement of the tibial tunnel demonstrated a positive medium correlation with side-to-side difference of anterior knee laxity as measured by a KT-1000 arthrometer ( r = 0.430; P < .001). The anterior group reported significantly better distribution of IKDC grading as compared with the posterior group (26 grade A and 6 grade B vs 15 grade A and 13 grade B; P = .043; V = 0.297). The pivot-shift test results and outcome scores showed no significant differences between the groups. Conclusion: Using the posterior border of the LMAH as an intraoperative landmark yields a wide range of tibial tunnel locations along the tibial plateau, with anterior placement of the tibial tunnel leading toward improved anterior knee stability.
- Published
- 2021
31. Retrograde Intramedullary Nailing Hardware Failure of a Supracondylar Distal Femur Fracture With Intercondylar Extension
- Author
-
Mark D Miller, Jorge Perera, Erin Smith, and Jeffrey Burnette
- Subjects
General Engineering - Published
- 2022
32. Dietary Exposure to United States Food and Drug Administration-Approved Synthetic Food Colors in Children, Pregnant Women, and Women of Childbearing Age Living in the United States
- Author
-
Asa Bradman, Rosemary Castorina, Ruwan Thilakaratne, Mayela Gillan, Teja Pattabhiraman, Anuroop Nirula, Melanie Marty, and Mark D. Miller
- Subjects
food dye ,and promotion of well-being ,Adolescent ,Health, Toxicology and Mutagenesis ,Color ,human exposure ,Toxicology ,Dietary Exposure ,children ,Pregnancy ,Behavioral and Social Science ,NHANES ,Humans ,Preschool ,3.3 Nutrition and chemoprevention ,Child ,Nutrition ,Pediatric ,United States Food and Drug Administration ,Public Health, Environmental and Occupational Health ,erythrosine ,Prevention of disease and conditions ,Nutrition Surveys ,United States ,Diet ,pregnant women ,ADI ,Child, Preschool ,Female ,Pregnant Women - Abstract
The Food and Drug Administration (FDA) regulates artificial food colors (AFCs) in the United States. Exposure to AFCs has raised concerns about adverse behavioral effects in children. We quantified AFC exposure in women of childbearing age, pregnant women, and children and compared them to FDA and World Health Organization acceptable daily intakes (ADIs). We estimated the “typical” and “high” single-day and two-day average dietary exposure to each AFC (mg/kg/day) based on laboratory measurements and food consumption data from the 2015–2016 National Health and Nutrition Examination Survey (NHANES). We also examined whether AFC intake differed by income, education, and ethnicity. Exposure tended to be higher in children and the highest AFC exposure was found for Red No. 40. Children’s mean and 95th percentile FD&C Red No. 3 estimated intakes exceeded the ADIs in some instances. Juice drinks, soft drinks, icings, and ice cream cones were major foods contributing to children’s (
- Published
- 2022
33. Sports Cardiology: Put Your Heart into It
- Author
-
Mark D. Miller
- Subjects
Cardiology ,Humans ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,Sports Medicine ,Sports - Published
- 2022
34. Disagreement in Pass Rates Between Strength and Performance Tests in Patients Recovering From Anterior Cruciate Ligament Reconstruction
- Author
-
Xavier D. Thompson, Amelia S. Bruce, Mandeep Kaur, David R. Diduch, Stephen F. Brockmeier, Mark D. Miller, F. Winston Gwathmey, Brian C. Werner, and Joe M. Hart
- Subjects
Adult ,Male ,Adolescent ,Anterior Cruciate Ligament Reconstruction ,Anterior Cruciate Ligament Injuries ,Physical Therapy, Sports Therapy and Rehabilitation ,Quadriceps Muscle ,Return to Sport ,Young Adult ,Cross-Sectional Studies ,Humans ,Orthopedics and Sports Medicine ,Female ,Muscle Strength - Abstract
Background: Performance on strength and functional tests is often used to guide postoperative rehabilitation progress and return to activity decisions after anterior cruciate ligament reconstruction (ACLR). Clinicians may have difficulty in determining which criteria to follow if there is disagreement in performance outcomes among the tests. Purpose/Hypothesis: The purpose of this study was to compare pass rates between strength tests and single-leg hop (SLHOP) tests among men and women and between patients with lower and higher preinjury activity levels recovering from ACLR. We hypothesized that pass rates would be nonuniformly distributed among test types, sex, and activity level and that more participants would pass hop tests than strength tests. Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 299 participants (146 men; 153 women)—at a mean of 6.8 ± 1.4 months after primary, unilateral, and uncomplicated ACLR (mean age, 23 ± 9.7 years; mean height, 172 ± 10.5 cm; mean mass, 75.8 ± 18.4 kg)—completed testing. Quadri.tif strength was evaluated using peak torque during isokinetic knee extension at 90 deg/s and 180 deg/s. Jump distance during the SLHOP and triple hop tests was measured (in cm). Strength and hop test measures were evaluated based on the limb symmetry index ((LSI) = (ACLR / contralateral side) × 100). We operationally defined “pass” as >90% on the LSI. Results: Pass rates were nonuniformly distributed between isokinetic knee extension at 90 deg/s and the SLHOP test ( χ2 = 18.64; P < .001). Disagreements between isokinetic testing at 90 deg/s and the SLHOP test occurred in 36.5% (109/299) of the participants. Among those who failed strength testing and passed hop testing, a greater portion reported higher activity levels before their injury ( χ2 = 6.90; P = .01); however, there was no difference in pass rates between men and women. Similar patterns of disagreement were observed between all strength test and hop test outcomes. Conclusion: ACLR patients with higher activity levels may be more likely to pass hop testing despite failing quadri.tif strength testing. This may be an indicator of movement compensations to achieve jump symmetry in the presence of quadri.tif weakness.
- Published
- 2022
35. Case Report Demonstrating Multifactorial Risks of Anterior Cruciate Ligament Re-tear Injuries and Appropriate Response Among Those With High Chance of Recurrence
- Author
-
Jorge Perera, Mark D Miller, and Paul Danahy
- Subjects
General Engineering - Published
- 2022
36. Anesthesia for Athletes
- Author
-
Mark D. Miller
- Subjects
Athletes ,Humans ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,Anesthesia - Published
- 2022
37. Exposures to FD&C synthetic color additives from over-the-counter medications and vitamins in United States children and pregnant women
- Author
-
Ruwan Thilakaratne, Rosemary Castorina, Mayela Gillan, Dorothy Han, Teja Pattabhiraman, Anuroop Nirula, Mark D. Miller, Melanie Marty, Arlie Lehmkuhler, Alyson Mitchell, and Asa Bradman
- Subjects
Epidemiology ,Public Health, Environmental and Occupational Health ,Toxicology ,Pollution - Abstract
Background Food and Drug Administration (FDA) Food Drug and Cosmetic (FD&C) synthetic color additives (SCAs) have been associated with attentional and behavioral problems in children. Efforts to quantify exposure have focused on foods, while the contribution of medications and supplements remains unknown. Objective To estimate exposures to SCAs in children (2–16 years) and pregnant women from intake of common over-the-counter (OTC) medications and vitamins. Methods We estimated single-day exposure (mg/kg/day) to FD&C SCAs based on measurements of 25 different products and recommended dosages on product labels. Exposures were compared to SCA exposure estimates from food we previously developed and acceptable daily intakes (ADIs) established by FDA and the World Health Organization. Results The highest exposure was found for FD&C Red No. 40 in a children’s cold/cough/allergy syrup. A child aged 12–16 years consuming the maximum daily dosage would have an exposure of 0.221 mg/kg/day, which is twice this age group’s typical exposure to this additive from food. No estimated exposures exceeded the ADIs. Significance Some children’s OTC medications and vitamins may cause daily SCA exposures comparable to those from foods. OTC medications and vitamins should be considered in efforts to quantify population exposure to FD&C SCAs. Impact Exposure to synthetic color additives (SCAs) from foods has been associated with behavioral problems in children. Exposures from over-the-counter (OTC) medications and vitamins remain unquantified despite widespread use. We estimated exposures in children and pregnant women for 25 different OTC medication and vitamin products sold in the United States. While exposures were below acceptable daily intakes (ADIs) established by the US Food and Drug Administration and the World Health Organization, some were comparable to typical daily exposures from foods. This work critically informs future SCA exposure assessments and provides valuable information for parents concerned about the health effects of SCAs.
- Published
- 2022
38. Management of Osteolysis in Revision ACL: The Role of Single-Stage Reconstruction
- Author
-
Courtney A. Quinn, F. Winston Gwathmey, and Mark D. Miller
- Published
- 2022
39. Arthroscopic meniscus repair: Inside-out technique
- Author
-
Christopher P. Bankhead and Mark D. Miller
- Published
- 2022
40. Anterior Cruciate Ligament Injury and Reconstruction
- Author
-
Justin W. Griffin, Mark D. Miller, Abbey DeBruin, Emma Klosterman, Clint Benge, and Geoffrey S. Baer
- Published
- 2022
41. Posterior cruciate ligament tibial inlay
- Author
-
Jordan D. Walters and Mark D. Miller
- Published
- 2022
42. Contributors
- Author
-
Abed Abdelaziz, Geoffrey D. Abrams, Christopher R. Adams, Zahab S. Ahsan, Doruk Akgün, Michael J. Alaia, Nedal Al-Khatib, Answorth A. Allen, David W. Altchek, Annunziato Amendola, Brittany M. Ammerman, Luca Andriolo, Peter Angele, Adam Anz, Elizabeth A. Arendt, Justin W. Arner, Neal S. Elattrache, Frederick M. Azar, Bernard R. Bach, Joanne Page Elston Baird, Champ L. Baker, Christopher P. Bankhead, Ryan H. Barnes, Lachlan Batty, Asheesh Bedi, Knut Beitzel, John W. Belk, Neilen A. Benvegnu, Andrew Bernhardson, David L. Bernholt, Daniel P. Berthold, Blake M. Bodendorfer, Angelo Boffa, Pascal Boileau, Kyle Borque, Craig R. Bottoni, James P. Bradley, Tyler J. Brolin, Matthew L. Brown, Robert Browning, William D. Bugbee, Gaetano Lo Bue, Joseph P. Burns, Charles A. Bush-Joseph, Jacob G. Calcei, Jourdan M. Cancienne, Connor K. Cannizzaro, James B. Carr, Thomas R. Carter, Simone Cerciello, Jorge Chahla, Peter N. Chalmers, Neal C. Chen, Timothy T. Cheng, Mark S. Cohen, Brian J. Cole, Nolan B. Condron, Corey S. Cook, Joe D. Cooper, R. Alexander Creighton, Navya Dandu, Richard M. Danilkowicz, Victor Danzinger, Robert S. Dean, Thomas DeBerardino, Laura DeGirolamo, David DeJour, Connor M. Delman, Ian J. Dempsey, Patrick J. Denard, Eric J. Dennis, Aman Dhawan, Aad A.M. Dhollander, Connor C. Diaz, Jonathan F. Dickens, David Diduch, Alessandro Di Martino, Joshua S. Dines, Brenton W. Douglass, Justin Drager, Alex G. Dukas, Corey R. Dwyer, Nicholas J. Ebert, Bassem El Hassan, Johnny El Rayes, Bryant P. Elrick, Brandon J. Erickson, Aghogho Evuarherhe, Gregory C. Fanelli, Jack Farr, John J. Fernandez, Larry D. Field, Giuseppe Filardo, Julia Fink, David C. Flanigan, Enrico M. Forlenza, Brian Forsythe, Thomas Fradin, Rachel M. Frank, Michael T. Freehill, Heather Freeman, Lisa G.M. Friedman, Steven DeFroda, Freddie H. Fu, John P. Fulkerson, Ian Gao, Grant E. Garrigues, Pablo E. Gelber, Alan Getgood, Ron Gilat, Scott D. Gillogly, Daniel B. Goldberg, Andreas H. Gomoll, Benjamin R Graves, Tinker Gray, Nathan L. Grimm, Florian Grubhofer, Jordan A. Gruskay, Ibrahim M. Haidar, James Hammond, Fucai Han, Payton Harris, Robert U. Hartzler, Carolyn M. Hettrich, Justin E. Hill, Takashi Hoshino, Benjamin W. Hoyt, Hailey P. Huddleston, Jonathan D. Hughes, Anthony J. Ignozzi, Mary Lloyd Ireland, Eiji Itoi, Evan W. James, Andrew E. Jimenez, Christopher C. Kaeding, Ajay C. Kanakamedala, James S. Kercher, Benjamin S. Kester, W. Ben Kibler, Derrick M. Knapik, Thomas P. Knapp, Baris Kocaoglu, Marc Korn, Avinaash Korrapati, John E. Kuhn, Laurent Lafosse, Thibault Lafosse, Joseph D. Lamplot, Robert F. LaPrade, Lior Laver, Arash Lavian, Ophelie Z. Lavoie-Gagne, Lance E. LeClere, Kenneth M. Lin, Adam Lindsay, Laughter Lisenda, Robert Litchfield, Bhargavi Maheshwer, Eric C. Makhni, Nathan Mall, Richard A. Marder, Fabrizio Margheritini, Robert G. Marx, David Matson, Augustus D. Mazzocca, Eric C. McCarty, L. Pearce McCarty, Ashley Mehl, Kaare S. Midtgaard, Mark D. Miller, Peter J. Millett, Raffy Mirzayan, Gilbert Moatshe, Jill Monson, Christian Moody, Philipp Moroder, Andres R. Muniz Martinez, Stefano Muzzi, Emily Naclerio, Levy Nathan, Philipp Niemeyer, Cédric Ngbilo, Gregory P. Nicholson, Philip-C. Nolte, Ali S. Noorzad, Gordon Nuber, Michael J. O’Brien, Robert S. O’Connell, Evan A. O’Donnell, Kieran O’Shea, James L. Pace, Michael J. Pagnani, Kevin C. Parvaresh, Jhillika Patel, Liam A. Peebles, Evan M. Polce, Rodrigo Sandoval Pooley, CAPT Matthew T. Provencher, Ryan J. Quigley, Courtney Quinn, M. Brett Raynor, David Ring, Avi S. Robinson, Scott A. Rodeo, William G. Rodkey, Anthony A. Romeo, Joseph J. Ruzbarsky, Orlando D. Sabbag, Marc R. Safran, Michael J. Salata, Ian Savage-Elliott, Felix H. Savoie, Donald J Scholten, Aaron Sciascia, K. Donald Shelbourne, Seth L. Sherman, Monica M. Shoji, Adam M. Smith, Matthew V. Smith, Patrick A. Smith, Bertrand Sonnery-Cottet, Yosef Sourugeon, Eric J. Strauss, Caroline Struijk, Geoffrey S. Van Thiel, John M. Tokish, Marc Tompkins, Joseph S. Tramer, Nicholas Trasolini, Anna Tross, Colin L. Uyeki, Evan E. Vellios, Angelina M. Vera, Peter C.M. Verdonk, René Verdonk, Dirk W. Verheul, Nikhil N. Verma, Thais Dutra Vieira, Gustavo Vinagre, Kyle R. Wagner, Jordan D. Walters, Jon J.P. Warner, Russell F. Warren, Brian R. Waterman, Karl Wieser, Brady T. Williams, Andy Williams, Matthew T. Winterton, Kelsey Wise, Stephanie Wong, Ivan Wong, Elisabeth Wörner, Joshua Wright-Chisem, Robert W. Wysocki, Nobuyuki Yamamoto, Adam B. Yanke, Yaniv Yonai, Anthony J. Zacharias, and Alexander Ziedas
- Published
- 2022
43. Associated Morbidity After the Percutaneous Release of the Medial Collateral Ligament for Knee Arthroscopy
- Author
-
Thomas E. Moran, John T. Awowale, Mark D. Miller, Michael A. Fox, and Brian C. Werner
- Subjects
030222 orthopedics ,Medial collateral ligament ,medicine.medical_specialty ,Percutaneous ,medicine.diagnostic_test ,biology ,business.industry ,Visual analogue scale ,Arthroscopy ,030229 sport sciences ,biology.organism_classification ,Surgery ,Saphenous nerve ,03 medical and health sciences ,Valgus ,0302 clinical medicine ,Text mining ,Medicine ,Orthopedics and Sports Medicine ,Young adult ,business - Abstract
Purpose To summarize available data on the morbidity associated with percutaneous release of the medial collateral ligament (MCL) of the knee during arthroscopy via a “pie-crusting” technique. Methods A search of the literature was performed using the MEDLINE and Web of Science databases to identify studies examining the morbidity of percutaneous MCL release during arthroscopy. Only English-language articles were included; technical articles and studies not focused on the use of this technique were omitted. Two independent reviewers performed the literature search, data extraction, and quality assessment. The outcomes analyzed included resultant knee instability, functional outcome scores, visual analog scale pain scores, and saphenous nerve or greater saphenous vein injury. Results Six studies met the eligibility criteria. The studies included a total of 234 knees undergoing MCL release, with a mean patient age of 41.1 years. This MCL release typically generated grade I MCL laxity, which usually diminished or resolved over time and did not require brace application. The functional outcome scores of patients undergoing MCL release did not differ from those of patients undergoing the same procedure without MCL release. Postoperative pain was not significantly different between patients who underwent MCL release and those who did not. There was a 0% incidence of injury to the saphenous nerve or greater saphenous vein with MCL release in the included studies. Conclusions Percutaneous MCL release during knee arthroscopy is a method of increasing the medial tibiofemoral joint space without causing any significant short- or long-term complications including residual valgus instability, pain, loss of function, or damage to surrounding structures. Level of Evidence Level IV, systematic review of Level IV studies.
- Published
- 2020
44. Posterior Cruciate Ligament Reconstruction in the Multiple Ligament Injured Knee
- Author
-
Mark D. Miller and Michelle E. Kew
- Subjects
medicine.medical_specialty ,Posterior Cruciate Ligament Reconstruction ,Physical examination ,Knee Injuries ,Tibial inlay ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Femur ,030222 orthopedics ,Tibia ,medicine.diagnostic_test ,business.industry ,Critically ill ,030229 sport sciences ,musculoskeletal system ,Neurovascular bundle ,Surgery ,medicine.anatomical_structure ,Posterior cruciate ligament ,Ligament ,Posterior Cruciate Ligament ,business ,Knee injuries - Abstract
Multiligamentous knee injuries are challenging to treat and diagnose. Posterior cruciate ligament (PCL) injuries are commonly found in the constellation of injuries included in a multiligamentous knee injury and are caused by a posteriorly directed force on the proximal tibia with relation to the femoral condyles. A thorough history and physical examination should be performed to evaluate for associated neurovascular injuries and associated ligamentous, chondral, or bony injuries. Nonsurgical management is reserved for patients who are critically ill or have very low activity demands. Surgical reconstruction is recommended for most patients with multiligamentous knee injuries. The PCL reconstruction can be undertaken with several different graft options and reconstruction techniques, including the transtibial, arthroscopic tibial inlay, and open tibial inlay approach. The literature has a paucity of data regarding outcomes among the various reconstructive options, so the optimal surgical technique has not been established.
- Published
- 2020
45. Using High-Throughput Screening to Evaluate Perturbations Potentially Linked to Neurobehavioral Outcomes: A Case Study Using Publicly Available Tools on FDA Batch-Certified Synthetic Food Dyes
- Author
-
Nathalie Pham, Melanie A. Marty, and Mark D. Miller
- Subjects
biology ,Molecular Structure ,United States Food and Drug Administration ,High-throughput screening ,Dopaminergic ,Food Coloring Agents ,General Medicine ,Computational biology ,Toxicology ,Aryl hydrocarbon receptor ,United States ,High-Throughput Screening Assays ,Nuclear receptor ,Hormone receptor ,In vivo ,biology.protein ,Animals ,Humans ,Animal studies ,Receptor ,Food Analysis ,Software - Abstract
There is growing evidence from human and animal studies indicating an association between exposure to synthetic food dyes and adverse neurobehavioral outcomes in children. However, data gaps persist for potential mechanisms by which the synthetic food dyes could elicit neurobehavioral impacts. We developed an approach to evaluate seven US FDA-batch-certified food dyes using publicly available high-throughput screening (HTS) data from the US EPA's Toxicity Forecaster to assess potential underlying molecular mechanisms that may be linked to neurological pathway perturbations. The dyes were screened through 270 assays identified based on whether they had a neurological-related gene target and/or were mapped to neurodevelopmental processes or neurobehavioral outcomes, and were conducted in brain tissue, targeted specific hormone receptors, or targeted oxidative stress and inflammation. Some results provided support for neurological impacts found in human and animal studies, while other results showed a lack of correlation with in vivo findings. The azo dyes had a range of activity in assays mapped to G-protein-coupled receptors and were active in assays targeting dopaminergic, serotonergic, and opioid receptors. Assays mapped to nuclear receptors (androgen, estrogen, and thyroid hormone) also exhibited activity with the food dyes. Other molecular targets included the aryl hydrocarbon receptor, acetylcholinesterase, and monoamine oxidase. The Toxicological Prioritization Index tool was used to visualize the results of the Novascreen assays. Our results highlight certain limitations of HTS assays but provide insight into potential underlying mechanisms of neurobehavioral effects observed in in vivo animal toxicology studies and human clinical studies.
- Published
- 2021
46. Determining the Ratio of Wedge Height to Degree of Correction for Anterior Tibial Closing Wedge Osteotomies for Excessive Posterior Tibial Slope
- Author
-
Daniel C. Lewis, Mark D. Miller, Robert D Turk, Christopher M Gaskin, Brian C. Werner, and Courtney A Quinn
- Subjects
Orthodontics ,business.product_category ,Anterior Cruciate Ligament Reconstruction ,Knee Joint ,Tibia ,business.industry ,medicine.medical_treatment ,Anterior cruciate ligament ,Physical Therapy, Sports Therapy and Rehabilitation ,Osteotomy ,Wedge (mechanical device) ,Reconstruction surgery ,Proximal tibia ,medicine.anatomical_structure ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Knee ,business ,Closing wedge - Abstract
Background: Anterior closing wedge osteotomy of the proximal tibia may be considered in revision anterior cruciate ligament (ACL) reconstruction surgery for patients with excessive posterior tibial slope (PTS). Purpose: (1) To determine the ratio of wedge thickness to degrees of correction for supratubercle (ST) versus transtubercle (TT) osteotomies for anterior closing wedge osteotomies and (2) to evaluate the accuracy of ST and TT osteotomies in achieving slope correction. Study Design: Controlled laboratory study. Methods: The computed tomography (CT) scans of 38 knees in 37 patients undergoing revision ACL reconstruction were used to simulate both ST and TT osteotomies. A 10° wedge was simulated in all CT models. The height of the wedge along the anterior tibia was recorded for each of the 2 techniques. The ratio of wedge height to achieved degree of correction was calculated. ST and TT osteotomies were performed on 3-dimensional (3D)–printed tibias of the 12 patients from the study group with the greatest PTS, after the desired degree of correction was determined. Pre- and postosteotomy slopes were measured for each tibia, and the actual change in slope was compared with the intended slope correction. Results: According to CT measurements, the ratio of wedge height to degree of correction was 0.99 ± 0.07 mm/deg for the ST osteotomy and 0.83 ± 0.06 mm/deg for the TT osteotomy ( P < .001). When these ratios were used to perform simulated osteotomies on the twelve 3D-printed tibias, the mean slope correction was within 1° to 2° of the intended slope correction, regardless of osteotomy location (ST or TT) or whether slope was measured on the medial or lateral plateau. The ST technique tended to undercorrect and the TT technique tended to overcorrect. Conclusion: When anterior tibial closing wedge osteotomies were removed to correct excessive PTS, removing a wedge with a ratio of 1 mm of wedge height for every 1° of intended correction for an ST technique and a ratio of 0.8 mm to 1° for a TT technique resulted in overall average slope correction within 1° to 2° of the target. Clinical Relevance: The calculated ratios will allow clinicians to more accurately correct PTS when performing anterior closing wedge tibial osteotomy.
- Published
- 2021
47. Collaboration in Performance of Physical Tasks: Effects on Outcomes and Communication.
- Author
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Robert E. Kraut, Mark D. Miller, and Jane Siegel
- Published
- 1996
- Full Text
- View/download PDF
48. Examining differences across journal rankings.
- Author
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R. Kelly Rainer Jr. and Mark D. Miller
- Published
- 2005
- Full Text
- View/download PDF
49. Developing and implementing core competencies in children’s environmental health for students, trainees and healthcare providers: a narrative review
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Lauren Zajac, Robert J. Geller, Rose H. Goldman, and Mark D. Miller
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Medical education ,Adult ,Health Personnel ,Specialty ,Review ,Competencies ,Affect (psychology) ,Education ,Environmental health ,Health care ,Climate change ,Humans ,Child ,Students ,Environmental justice ,LC8-6691 ,Education, Medical ,business.industry ,Environmental social determinates of health ,Core competency ,Child Health ,General Medicine ,Special aspects of education ,Health equity ,United States ,Child, Preschool ,Life expectancy ,Medicine ,Pediatric environmental health ,Health disparities ,business ,Healthcare providers - Abstract
Knowledge of the health impacts of environmental exposures (such as pollution disasters, poor air quality, water contamination, climate change) on children’s health has dramatically increased in the past 40 years. The World Health Organization (WHO) estimated that 23% of all deaths worldwide were attributable to the environment, and 26% of deaths in children less than 5 years old could be prevented with removal of environmental risks factors. Yet, little has permeated medical education, leaving pediatric providers ill equipped to address these issues. To address this gap, members from the Pediatric Environmental Health Specialty Units, a United States nationwide network of academically affiliated experts who have created numerous environmental health educational materials and programs, have identified fifteen core environmental health (EH) competencies needed by health care providers to enable them to effectively address environmental health concerns. These competencies can serve as the foundation for the development and implementation of relevant educational programs. The core EH competencies are based upon these foundational elements: 1) Definition of “children’s environmental health” that describes how environmental exposures (positive and negative) in early life influence the health and development in childhood and across the entire human life span 2) Children are not “little adults” and so have unique vulnerabilities to environmental hazards; 3) Environmental health inequities exist, causing some children to have a disproportionate amount of unhealthy exposures and consequently a greater risk of adverse effects; 4) Climate change will translate to numerous adverse health effects that will particularly affect children worldwide. In this article, the authors describe the core environmental health competencies and provide resources, online tools, strategies, and examples targeted to all levels of training and practice to better enable leaders and educators to bring this important content to the forefront.
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- 2021
50. A novel meniscofemoral ligament variant intra-substance to the PCL
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Jens T, Verhey, David G, Deckey, Sailesh, Tummala, Jeffrey D, Hassebrock, Donald, Dulle, Jeremiah R, Long, Mark D, Miller, and Anikar, Chhabra
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Knee Joint ,Ligaments, Articular ,Humans ,Knee ,Posterior Cruciate Ligament ,Menisci, Tibial ,Biomechanical Phenomena - Abstract
While much detail is known about each anatomic structure of the knee and its contributory effect on biomechanics, our understanding is still evolving. In particular, the function of the meniscofemoral ligaments and their anatomical variants have yet to be fully described. In this report, a never-before-described anatomical meniscofemoral ligament variant intra-substance to the PCL is presented. Arthroscopists should be aware of the novel variant as a growing number of studies have demonstrated the biomechanical importance of the meniscofemoral ligaments in protecting the lateral meniscus and supporting the function of the PCL.Level of Evidence: IV.
- Published
- 2021
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