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In this paper, we build and compare multiple speech systems for the automatic evaluation of the severity of a speech impairment due to oral cancer, based on spontaneous speech. To be able to build and evaluate such systems, we collected a new spontaneous oral cancer speech corpus from YouTube consisting of 124 utterances rated by 100 non-expert listeners and one trained speech-language pathologist, which we made publicly available. We evaluated the systems in two scenarios: a scenario where transcriptions were available (reference-based) and a scenario where transcriptions might not be available (reference-free). The results of extensive experiments showed that (1) when transcriptions were available, the highest correlation with the human severity ratings was obtained using an automatic speech recognition (ASR) retrained with oral cancer speech. (2) When transcriptions were not available, the best results were achieved by a LASSO model using modulation spectrum features. (3) We found that naive listeners’ ratings are highly similar to the speech pathologist's ratings for speech severity evaluation. (4) The use of binary labels led to lower correlations of the automatic methods with the human ratings than using severity scores.

The aim of this work is to develop a reusable polypropylene glycol (PPG):β-cyclodextrin (βCD) biosensor for cortisol detection. To achieve the most stable support for βCD, we developed two PPG surfaces. The first surface is based on a gold surface modified with SAM of 3-mercaptopropionic acid (3MPA), and the second surface is based on a glassy carbon surface grafted with 4-carboxyphenyl diazonium salt. We characterized both surfaces by EIS, XPS, and ATR-FTIR and evaluated the stability and reusability of each surface. We found the GC-carboxyphenyl-PPG:βCD is stable for at least 1 month. We have also demonstrated the reusability of the surface up to 10 times. In detecting cortisol, we used a nonfaradaic electrochemical impedance capacitive model to interpret the surface confirmation changes. We achieved sensitive detection of cortisol in PBS buffer, urine, and saliva with limit of detection of 2.13, 1.29, and 1.33 nM, respectively.

Introduction: Surgical treatment of oral cancer leads to lasting changes of the vocal tract and individuals treated for oral cancer (ITFOC) often experience speech problems. The purpose of this study was to analyse the acoustic properties of the spontaneous speech of individuals who were surgically treated for oral cancer. It was investigated (1) how key spectral measures of articulation change post-treatment; (2) whether changes are more related to target manner or place of articulation; and (3) how spectral measures develop at various time points following treatment.Method: A corpus consisting of 32.850 tokens was constructed by manually segmenting the speech of five (four female - one male) American English speaking ITFOC. General acoustic characteristics (duration and spectral tilt), plosives (burst frequency), fricatives (centre of gravity and spectral skewness), and vowels (F1 and F2) were analysed using linear mixed effects regression and compared to control speech. Moreover, a within speaker analysis was performed for speakers with multiple recordings.Results: Manner of articulation is more predictive of post-treatment changes than place of articulation. Compared to controls, ITFOC produced the fricatives /f, v, θ, ð, s, z, ʃ, ʒ/ with a lower centre of gravity while no differences were found in plosives and vowels. Longitudinal analyses show high within-speaker variation, but general improvements one-year post-treatment.Conclusions: Surgical oral cancer treatment changes the spectral properties of speech. Fricatives with varying manner of articulations were distorted, suggesting that manner of articulation is more predictive than place of articulation in identifying general problem areas for ITFOC.

The BICEP3 Polarimeter is a small aperture, refracting telescope, dedicated to the observation of the Cosmic Microwave Background (CMB) at 95GHz. It is designed to target degree angular scale polarization patterns, in particular the very-much-sought-after primordial B-mode signal, which is a unique signature of cosmic inflation. The polarized signal from the sky is reconstructed by differencing co-localized, orthogonally polarized superconducting Transition Edge Sensor (TES) bolometers. In this work, we present absolute measurements of the polarization response of the detectors for more than $\sim 800$ functioning detector pairs of the BICEP3 experiment, out of a total of $\sim 1000$. We use a specifically designed Rotating Polarized Source (RPS) to measure the polarization response at multiple source and telescope boresight rotation angles, to fully map the response over 360 degrees. We present here polarization properties extracted from on-site calibration data taken in January 2022. A similar calibration campaign was performed in 2018, but we found that our constraint was dominated by systematics on the level of $\sim0.5^\circ$. After a number of improvements to the calibration set-up, we are now able to report a significantly lower level of systematic contamination. In the future, such precise measurements will be used to constrain physics beyond the standard cosmological model, namely cosmic birefringence., Submitted to: SPIE Astronomical Telescopes + Instrumentation (AS22)

Polarized Galactic synchrotron emission is an undesirable foreground for cosmic microwave background (CMB) experiments observing at frequencies $< 150$ GHz. We perform a combined analysis of observational data at 1.4, 2.3, 23, 30 and 33 GHz to quantify the spatial variation of the polarized synchrotron spectral index, $\beta^{pol}$, on $\sim3.5^\circ$ scales. We compare results from different data combinations to address limitations and inconsistencies present in these public data, and form a composite map of $\beta^{pol}$. Data quality masking leaves 44% sky coverage (73% for $|b|> 45^\circ$). Generally $-3.2 < \beta^{pol} \lesssim -3$ in the inner Galactic plane and spurs, but the Fan Region in the outer Galaxy has a flatter index. We find a clear spectral index steepening with increasing latitude south of the Galactic plane with $\Delta \beta^{pol}=0.4$, and a smaller steepening of $0.25$ in the north. Near the south Galactic pole the polarized synchrotron spectral index is $\beta^{pol} \approx -3.4$. Longitudinal spectral index variations of $\Delta \beta^{pol} \sim 0.1$ about the latitudinal mean are also detected. Within the BICEP2/Keck survey footprint, we find consistency with a constant value, $\beta^{pol} = -3.25 \pm 0.04$ (statistical) $\pm 0.02$ (systematic). We compute a map of the frequency at which synchrotron and thermal dust emission contribute equally to the total polarized foreground. The limitations and inconsistencies among datasets encountered in this work make clear the value of additional independent surveys at multiple frequencies, especially between $10-20$ GHz, provided these surveys have sufficient sensitivity and control of instrumental systematic errors., Comment: 21 pages, 18 figures, accepted by ApJ

The BICEP/Keck experiment (BK) is a series of small-aperture refracting telescopes observing degree-scale Cosmic Microwave Background (CMB) polarization from the South Pole in search of a primordial $B$-mode signature. This $B$-mode signal arises from primordial gravitational waves interacting with the CMB, and has amplitude parametrized by the tensor-to-scalar ratio $r$. Since 2016, BICEP3 and the Keck Array have been observing with 4800 total antenna-coupled transition-edge sensor detectors, with frequency bands spanning 95, 150, 220, and 270 GHz. Here we present the optical performance of these receivers from 2016 to 2019, including far-field beams measured in situ with an improved chopped thermal source and instrument spectral response measured with a field-deployable Fourier Transform Spectrometer. As a pair differencing experiment, an important systematic that must be controlled is the differential beam response between the co-located, orthogonally polarized detectors. We generate per-detector far-field beam maps and the corresponding differential beam mismatch that is used to estimate the temperature-to-polarization leakage in our CMB maps and to give feedback on detector and optics fabrication. The differential beam parameters presented here were estimated using improved low-level beam map analysis techniques, including efficient removal of non-Gaussian noise as well as improved spatial masking. These techniques help minimize systematic uncertainty in the beam analysis, with the goal of constraining the bias on $r$ induced by temperature-to-polarization leakage to be subdominant to the statistical uncertainty. This is essential as we progress to higher detector counts in the next generation of CMB experiments., 8 pages, 3 figures. Accepted by the Journal of Low Temperature Physics (Proceedings of the 18th International Workshop on Low Temperature Detectors)

We report on the development of a polarization-sensitive dichroic (150/220 GHz) detector array for the Cosmology Large Angular Scale Surveyor (CLASS) delivered to the telescope site in June 2019. In concert with existing 40 and 90 GHz telescopes, the 150/220 GHz telescope will make observations of the cosmic microwave background over large angular scales aimed at measuring the primordial B-mode signal, the optical depth to reionization, and other fundamental physics and cosmology. The 150/220 GHz focal plane array consists of three detector modules with 1020 transition edge sensor (TES) bolometers in total. Each dual-polarization pixel on the focal plane contains four bolometers to measure the two linear polarization states at 150 and 220 GHz. Light is coupled through a planar orthomode transducer (OMT) fed by a smooth-walled feedhorn array made from an aluminum-silicon alloy (CE7). In this work, we discuss the design, assembly, and in-lab characterization of the 150/220 GHz detector array. The detectors are photon-noise limited, and we estimate the total array noise-equivalent power (NEP) to be 2.5 and 4 aW$\sqrt{\mathrm{s}}$ for 150 and 220 GHz arrays, respectively., Comment: 8 pages, 5 figures, Published in J Low Temp Phys

In this paper, we propose a new approach to pathological speech synthesis. Instead of using healthy speech as a source, we customise an existing pathological speech sample to a new speaker's voice characteristics. This approach alleviates the evaluation problem one normally has when converting typical speech to pathological speech, as in our approach, the voice conversion (VC) model does not need to be optimised for speech degradation but only for the speaker change. This change in the optimisation ensures that any degradation found in naturalness is due to the conversion process and not due to the model exaggerating characteristics of a speech pathology. To show a proof of concept of this method, we convert dysarthric speech using the UASpeech database and an autoencoder-based VC technique. Subjective evaluation results show reasonable naturalness for high intelligibility dysarthric speakers, though lower intelligibility seems to introduce a marginal degradation in naturalness scores for mid and low intelligibility speakers compared to ground truth. Conversion of speaker characteristics for low and high intelligibility speakers is successful, but not for mid. Whether the differences in the results for the different intelligibility levels is due to the intelligibility levels or due to the speakers needs to be further investigated., 6 pages, 3 figures. Accepted to the 11th ISCA Speech Synthesis Workshop (2021)

The CHIME/FRB Project has recently released its first catalog of fast radio bursts (FRBs), containing 492 unique sources. We present results from angular cross-correlations of CHIME/FRB sources with galaxy catalogs. We find a statistically significant ($p$-value $\sim 10^{-4}$, accounting for look-elsewhere factors) cross-correlation between CHIME FRBs and galaxies in the redshift range $0.3 \lesssim z \lesssim 0.5$, in three photometric galaxy surveys: WISE$\times$SCOS, DESI-BGS, and DESI-LRG. The level of cross-correlation is consistent with an order-one fraction of the CHIME FRBs being in the same dark matter halos as survey galaxies in this redshift range. We find statistical evidence for a population of FRBs with large host dispersion measure ($\sim 400$ pc cm$^{-3}$), and show that this can plausibly arise from gas in large halos ($M \sim 10^{14} M_\odot$), for FRBs near the halo center ($r \lesssim 100$ kpc). These results will improve in future CHIME/FRB catalogs, with more FRBs and better angular resolution., 26 pages, 16 figures, published in ApJ

The discovery of a repeating Fast Radio Burst (FRB) source, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has yet been detected in spite of many recent FRB discoveries and follow-ups, suggesting repeaters may be rare in the FRB population. Here we report the detection of six repeat bursts from FRB 180814.J0422+73, one of the 13 FRBs detected by the Canadian Hydrogen Intensity Mapping Experiment (CHIME) FRB project during its pre-commissioning phase in July and August 2018. These repeat bursts are consistent with originating from a single position on the sky, with the same dispersion measure (DM), ~189 pc cm-3. This DM is approximately twice the expected Milky Way column density, and implies an upper limit on the source redshift of 0.1, at least a factor of ~2 closer than FRB 121102. In some of the repeat bursts, we observe sub-pulse frequency structure, drifting, and spectral variation reminiscent of that seen in FRB 121102, suggesting similar emission mechanisms and/or propagation effects. This second repeater, found among the first few CHIME/FRB discoveries, suggests that there exists -- and that CHIME/FRB and other wide-field, sensitive radio telescopes will find -- a substantial population of repeating FRBs., Comment: accepted by Nature

We present an improved search for axion-like polarization oscillations in the cosmic microwave background (CMB) with observations from the Keck Array. An all-sky, temporally sinusoidal rotation of CMB polarization, equivalent to a time-variable cosmic birefringence, is an observable manifestation of a local axion field and potentially allows a CMB polarimeter to detect axion-like dark matter directly. We describe improvements to the method presented in previous work, and we demonstrate the updated method with an expanded dataset consisting of the 2012-2015 observing seasons. We set limits on the axion-photon coupling constant for mass $m$ in the range $10^{-23}$-$10^{-18}~\mathrm{eV}$, which corresponds to oscillation periods on the order of hours to years. Our results are consistent with the background model. For periods between $1$ and $30~\mathrm{d}$ ($1.6 \times 10^{-21} \leq m \leq 4.8 \times 10^{-20}~\mathrm{eV}$), the $95\%$-confidence upper limits on rotation amplitude are approximately constant with a median of $0.27^\circ$, which constrains the axion-photon coupling constant to $g_{\phi\gamma} < (4.5 \times 10^{-12}~\mathrm{GeV}^{-1}) m/(10^{-21}~\mathrm{eV}$), if axion-like particles constitute all of the dark matter. More than half of the collected BICEP dataset has yet to be analyzed, and several current and future CMB polarimetry experiments can apply the methods presented here to achieve comparable or superior constraints. In the coming years, oscillation measurements can achieve the sensitivity to rule out unexplored regions of the axion parameter space.

International audience; We present results from an analysis of all data taken by the BICEP2, Keck Array, and BICEP3 CMB polarization experiments up to and including the 2018 observing season. We add additional Keck Array observations at 220 GHz and BICEP3 observations at 95 GHz to the previous 95/150/220 GHz dataset. The Q/U maps now reach depths of 2.8, 2.8, and 8.8 μKCMB arcmin at 95, 150, and 220 GHz, respectively, over an effective area of ≈600 square degrees at 95 GHz and ≈400 square degrees at 150 and 220 GHz. The 220 GHz maps now achieve a signal-to-noise ratio on polarized dust emission exceeding that of Planck at 353 GHz. We take auto- and cross-spectra between these maps and publicly available WMAP and Planck maps at frequencies from 23 to 353 GHz and evaluate the joint likelihood of the spectra versus a multicomponent model of lensed ΛCDM+r+dust+synchrotron+noise. The foreground model has seven parameters, and no longer requires a prior on the frequency spectral index of the dust emission taken from measurements on other regions of the sky. This model is an adequate description of the data at the current noise levels. The likelihood analysis yields the constraint r0.05<0.036 at 95% confidence. Running maximum likelihood search on simulations we obtain unbiased results and find that σ(r)=0.009. These are the strongest constraints to date on primordial gravitational waves.

We report on the serendipitous discovery of three transient millimeter-wave sources using data from the Atacama Cosmology Telescope. The first, detected at R.A. = 273.8138, decl. = −49.4628 at ~50σ total, brightened from less than 5 mJy to at least 1100 mJy at 150 GHz with an unknown rise time shorter than 13 days, during which the increase from 250 mJy to 1100 mJy took only 8 minutes. Maximum flux was observed on 2019 November 8. The source's spectral index in flux between 90–150 GHz was positive, α = 1.5 ± 0.2. The second, detected at R.A. = 105.1584, decl. = −11.2434 at ~20σ total, brightened from less than 20 mJy to at least 300 mJy at 150 GHz with an unknown rise time shorter than 8 days. Maximum flux was observed on 2019 December 15. Its spectral index was also positive, α = 1.8 ± 0.2. The third, detected at R.A. = 301.9952, decl. = 16.1652 at ~40σ total, brightened from less than 8 mJy to at least 300 mJy at 150 GHz over a day or less but decayed over a few days. Maximum flux was observed on 2018 September 11. Its spectrum was approximately flat, with a spectral index of α = −0.2 ± 0.1. None of the sources were polarized to the limits of these measurements. The two rising-spectrum sources are coincident in position with M and K stars, while the third is coincident with a G star.

We present a voice conversion framework that converts normal speech into dysarthric speech while preserving the speaker identity. Such a framework is essential for (1) clinical decision making processes and alleviation of patient stress, (2) data augmentation for dysarthric speech recognition. This is an especially challenging task since the converted samples should capture the severity of dysarthric speech while being highly natural and possessing the speaker identity of the normal speaker. To this end, we adopted a two-stage framework, which consists of a sequence-to-sequence model and a nonparallel frame-wise model. Objective and subjective evaluations were conducted on the UASpeech dataset, and results showed that the method was able to yield reasonable naturalness and capture severity aspects of the pathological speech. On the other hand, the similarity to the normal source speaker's voice was limited and requires further improvements., Comment: Submitted to ICASSP 2022

BICEP3 is a 520 mm aperture on-axis refracting telescope at the South Pole, which observes the polarization of the cosmic microwave background (CMB) at 95 GHz to search for the B-mode signal from inflationary gravitational waves. In addition to this main target, we have developed a low-elevation observation strategy to extend coverage of the Southern sky at the South Pole, where BICEP3 can quickly achieve degree-scale E-mode measurements over a large area. An interesting E-mode measurement is probing a potential polarization anomaly around the CMB Cold Spot. During the austral summer seasons of 2018-19 and 2019-20, BICEP3 observed the sky with a flat mirror to redirect the beams to various low elevation ranges. The preliminary data analysis shows degree-scale E-modes measured with high signal-to-noise ratio., 12 pages, 10 figures; Figure 7 shows the correct file

A detection of curl-type ($B$-mode) polarization of the primary CMB would be direct evidence for the inflationary paradigm of the origin of the Universe. The BICEP/Keck Array (BK) program targets the degree angular scales, where the power from primordial $B$-mode polarization is expected to peak, with ever-increasing sensitivity and has published the most stringent constraints on inflation to date. BICEP Array (BA) is the Stage-3 instrument of the BK program and will comprise four BICEP3-class receivers observing at 30/40, 95, 150 and 220/270 GHz with a combined 32,000+ detectors; such wide frequency coverage is necessary for control of the Galactic foregrounds, which also produce degree-scale $B$-mode signal. The 30/40 GHz receiver is designed to constrain the synchrotron foreground and has begun observing at the South Pole in early 2020. By the end of a 3-year observing campaign, the full BICEP Array instrument is projected to reach $\sigma_r$ between 0.002 and 0.004, depending on foreground complexity and degree of removal of $B$-modes due to gravitational lensing (delensing). This paper presents an overview of the design, measured on-sky performance and calibration of the first BA receiver. We also give a preview of the added complexity in the time-domain multiplexed readout of the 7,776-detector 150 GHz receiver., Comment: Proceedings of SPIE 2020 (AS111). This article supersedes arXiv:1808.00568 and arXiv:2002.05228

The BICEP3 CMB Polarimeter is a small-aperture refracting telescope located at the South Pole and is specifically designed to search for the possible signature of inflationary gravitational waves in the Cosmic Microwave Background (CMB). The experiment measures polarization on the sky by differencing the signal of co-located, orthogonally polarized antennas coupled to Transition Edge Sensor (TES) detectors. We present precise measurements of the absolute polarization response angles and polarization efficiencies for nearly all of BICEP3s $\sim800$ functioning polarization-sensitive detector pairs from calibration data taken in January 2018. Using a Rotating Polarized Source (RPS), we mapped polarization response for each detector over a full 360 degrees of source rotation and at multiple telescope boresight rotations from which per-pair polarization properties were estimated. In future work, these results will be used to constrain signals predicted by exotic physical models such as Cosmic Birefringence., Comment: Proceedings submitted to SPIE 2020 (AS111). 12 pages, 5 figures, 2 tables

The BICEP/Keck Array experiment is a series of small-aperture refracting telescopes observing degree-scale Cosmic Microwave Background polarization from the South Pole in search of a primordial $B$-mode signature. As a pair differencing experiment, an important systematic that must be controlled is the differential beam response between the co-located, orthogonally polarized detectors. We use high-fidelity, in-situ measurements of the beam response to estimate the temperature-to-polarization (T $\rightarrow$ P) leakage in our latest data including observations from 2016 through 2018. This includes three years of BICEP3 observing at 95 GHz, and multifrequency data from Keck Array. Here we present band-averaged far-field beam maps, differential beam mismatch, and residual beam power (after filtering out the leading difference modes via deprojection) for these receivers. We show preliminary results of "beam map simulations," which use these beam maps to observe a simulated temperature (no $Q/U$) sky to estimate T $\rightarrow$ P leakage in our real data., Comment: 9 pages, 4 figures

In this work we describe upgrades to the Spider balloon-borne telescope in preparation for its second flight, currently planned for December 2021. The Spider instrument is optimized to search for a primordial B-mode polarization signature in the cosmic microwave background at degree angular scales. During its first flight in 2015, Spider mapped ~10% of the sky at 95 and 150 GHz. The payload for the second Antarctic flight will incorporate three new 280 GHz receivers alongside three refurbished 95- and 150 GHz receivers from Spider's first flight. In this work we discuss the design and characterization of these new receivers, which employ over 1500 feedhorn-coupled transition-edge sensors. We describe pre-flight laboratory measurements of detector properties, and the optical performance of completed receivers. These receivers will map a wide area of the sky at 280 GHz, providing new information on polarized Galactic dust emission that will help to separate it from the cosmological signal., 13 pages, 8 figures; as published in the conference proceedings for SPIE Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy X (2020)