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88 results on '"Marjanović Goran"'

1. Serum biomarkers and clinical characteristics of patients with Hodgkin lymphoma

Author

Simonović Olivera, Todorović Milena, Mihaljević Biljana, Stoimenov-Jevtović Tatjana, Petković Ivan, Mačukanović-Golubović Lana, and Marjanović Goran

Subjects
hodgkin disease, biomarkers, tumor, enzyme-linked immunosorbent assay, treatment outcome, prognosis, Medicine (General), R5-920
Abstract

Background/Aim. In classical Hodgkin’s lymphoma (cHL) the existing prognostic scoring systems do not include markers that adequately reflect the interaction of malignant Hodgkin and Reed-Sternberg (HRS) cells and tumor environment. The aim of this study was to determine the relationship between serum Galectin-1 (Gal-1) and soluble CD163 (sCD163) and the clinical status of patients with cHL, with special emphasis on the presence of relapse, progression, or resistance to the therapy applied. Methods. The research included 79 patients of whom 63 were patients with cHL, and the control group of 16 healthy volunteers. The study group of 63 patients with cHL included a subgroup of newly diagnosed patients without therapy, newly diagnosed patients with therapy, patients with relapse and progression of the disease and primary refractory patients during 2014 and 2015. Results. Analysis of the levels of sCD163 and Gal-1 within a group of patients suffering from cHL showed that the values of both molecules were higher in relapsed patients and the subgroup with progressive disease comparing to the subgroup of newly diagnosed patients without therapy or patients with therapy onset. Conclusion. Determination of Gal-1 and sCD163 levels is simple and reliable analysis that can contribute to the identification of high-risk patients with cHL and deserves inclusion in current prognostic scoring systems.

Published
2018
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2. State of the propulsive-group development for enhanced anti-armored guided missile

Author

Marjanović Goran, Kozomara Stevan, Stojković Srđan, Gligorijević Nikola, Živković Saša, and Pavković Bojan

Subjects
anti-armor rocket, rocket motor, propulsive group, starting (booster) motor, marching (sustainer) motor, propellant grain, thrust, pressure, range, Technology, Engineering (General). Civil engineering (General), TA1-2040
Abstract

The main propulsive group of anti-armor guided missile is reinforced by additional propulsive group with the aim to increase the range. Final concept of the propulsion has been adopted after consideration of several proposed solutions. Two additional motors are made and they are currently under development. The first results were obtained, and the additional motors at this stage are refined through the static tests as well as through the correction of the composition and the design of the propellant grains. An overview of the common procedure is described on the way to winning the final solution for rocket propulsion.

Published
2018

4. Study on histogenesis of enterochromaffin-like carcinoid in autoimmune atrophic gastritis associated with pernicious anemia

Author

Mačukanović-Golubović Lana, Katić Vuka, Rančić Gorana, Milenović Mladen, Marjanović Goran, and Golubović Zoran

Subjects
gastritis, atrophic, anemia, pernicious, autoimmune diseases, carcinoid tumor, enterochromaffin cells, histological techniques, Medicine (General), R5-920
Abstract

Background/Aim. Autoimmune atrophic fundic gastritis induces the pernicious anemia (PA), as well as the changes in both epithelium and endocrine cells of gastric mucosa. The most important complications are: achlorhydria, hypergastrinemia, gastric cancer and enterochromaffin-like ( ECL) carcinoid. The aim of this study was to examine ECL carcinoid histogenesis in A-gastritis associated with PA. Methods. During the period from 2000−2006, 65 patients with PA and 30 patients of the control group were examined. Histopathological examination was done in endoscopical biopsies of gastric mucosa fixed in 10% formaldehyde. Paraffin sections were stained with classic hematoxylin-eosin (HE); histochemical AB-PAS (pH 2.5), cytochemical argyrophilic Servier-Munger′s and immunocytochemical PAP methods for G cell identification and chromogranin A antibodies - specific marker for neuroendocrine ECL cells. Both G and ECL cells were counted per 20 fields, of surface 0.0245312 mm2 by a field. Basal gastrin serum levels were also examined by using radioimmunoassay (RIA) method. The obtained results were statisticaly calculated by using Student΄s t test. Results. Marked antral G cell hyperplasia associated with corporal ECL hyperplasia was found. ECL cell hyperplasia was of simplex, linear, adenomatoid type to the pattern of intramucous ECL cell carcinoid. An average number of G cells was statistically significant in the patients with PA as compared to the control group (p < 0.05) as well as an average number of ECL cells. Conclusion. We concluded that antral G cell hyperplasia accompanied by gastrinemia induces ECL hyperplasia and ECL corporal carcinoid in A-gastritis and that their histogenesis develops trough simple, linear and adenomatoide hyperplasia. .

Published
2007
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5. Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma

Author

Janković-Veličković Ljubinka, Đorđević Biljana, Rančić Gorana, and Marjanović Goran

Subjects
prostatic neoplasms, precancerous conditions, gene expression, Ki-67 antigen, histology, immunohistochemistry, Medicine (General), R5-920
Abstract

Background/Aim. Prostatic intraepithelial high grade neoplasia (PINHG) is accepted as preneoplastic lesion in prostatic carcinoma. One of the fundamental events in early oncogenesis is the disruption of proliferative activity. One of the numerous regulatory proteins is Ki-67 expressed in all proliferating cells. Index Ki-67 is considered to have prognostic significance. The aim of the study was to compare the level of proliferation in hyperplastic epithelium, prostatic carcinoma (Gleason score > 6) and PINHG. Methods. Micromorphological examination was done in 85 patients. Pathohistological analysis was performed on standard histologic specimens with the estimation of Gleason score and the presence of PINHG in its surroundings. Nuclear proliferative activity was analyzed immunohistochemically in 19 cases, using a monoclonal anti-Ki-67 antibody. Results. PINHG was found in prostatic carcinoma surrounding in 30% of the patients. In hyperplastic epithelia Ki-67 proliferative activity was 1,08, in PINHG 2,25 (p < 0,05), while in prostatic cancer, Ki-67 index was 17,64. Proliferative activity in prostatic carcinoma was significantly higher than in PINHG (p < 0,001) and hyperplasia (p < 0,001). Conclusion. This study confirmed that high grade PIN lesion predominately appears in the surrounding of poor or moderately differentiated prostate carcinoma, and that it represents progressive disorder of proliferation in preneoplastic and neoplastic prostatic epithelium. .

Published
2007
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6. Tissue microarray: A valuable method in diagnosis and prognosis of hematological malignances

Author

Marjanović Goran and Dojčinov Stefan

Subjects
tissue array analysis, hematologic neoplasms, immunohistocytochemistry, molecular diagnostic techniques, prognosis, immunophenotyping, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BACKGROUND: The novel technology of tissue microarray (TMA) allows rapid and cost-effective analysis of hundreds of markers on the same set of specimens. Limited amount of tissue that could be analyzed and problem of tissue heterogeneity, are the major drawbacks of TMA technique for immunohistochemical characterization of lymphomas. METHODS: In this paper 65 cases of lymphomas were analyzed using TMA with following panel of antibodies: BOB1, Oct2, Bcl2, Bcl6, CD20, CD21, CD23, CD3, CD5, CD10, CD43, CD79a, CD138, Cyclin D1, Ki67, MUM1, Pax5, p53. RESULTS: In 14 patients with diffuse large B-cell lymphoma (DLBCL), 5 were classified as germinative center and 3 as non-germinative center cases according to the Bcl6, CD10, and MUM1 positivity. Other 2 patients were identified as T cell rich B cell lymphoma based on morphology and Oct2 and BOB1 positivity of pleomorphic B lymphocytes. DLBCL with Bcl6+ immunophenotype had better overall survival than Bcl6- cases. All cases of classic mantle cell lymphoma had significantly lower Ki-67 proliferation index than blastoid subtypes. There were 14 cases of chronic lymphocytic leukemia/small cell lymphocytic lymphoma, 6 cases with follicular lymphoma, 5 cases of marginal zone lymphoma, and 7 cases of lymphoplazmacitoid lymphoma. In the indolent lymphoma group, survival of patients with p53+/- was poorer comparing to p53- group. CONCLUSION: We conclude that TMA technique is a valuable method in diagnosis and prognosis of lymphomas, which are considered very heterogeneous group of hematological neoplasms.

Published
2005
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7. Malakoplakia mimics urinary bladder cancer: A case report

Author

Ristić-Petrović Ana, Stojnev Slavica, Janković-Veličković Ljubinka, and Marjanović Goran

Subjects
malakoplakia, urinary bladder, diagnosis, differential, urinary bladder neoplasms, immunohistochemistry, Medicine (General), R5-920
Abstract

Introduction. Malakoplakia is an unusual and very rare chronic inflammatory disease. In bladder especially it can mimic malignancy and lead to serious misdiagnosis. Case report. We presented a case of a middle-aged woman with persistent macrohematuria and cystoscopically polypoid bladder mass that resembled a neoplastic process. The final diagnosis was based on cystoscopic biopsy and microscopic findings of acidophilic, foamy histiocytes with the presence of Michaelis-Gutmann inclusions which are characteristic for diagnosis of malakoplakia. Immunohistochemistry confirmed diagnosis by demonstrating CD68-positive macrophages. Conclusion. Urinary bladder malakoplakia should be considered in patients with persistent urinary tract infections and tumor mass at cystoscopy. Early identification with prompt antibiotic treatment can be helpful in avoiding unnecessary surgical interventions and in preventing development of possible complications. [Projekat Ministarstva nauke Republike Srbije, br. 175092]

Published
2013
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10. MIST: L0 Sparse Linear Regression with Momentum

Author

Marjanovic, Goran, Ulfarsson, Magnus O., and Hero III, Alfred O.

Subjects
Statistics - Machine Learning
Abstract

Significant attention has been given to minimizing a penalized least squares criterion for estimating sparse solutions to large linear systems of equations. The penalty is responsible for inducing sparsity and the natural choice is the so-called $l_0$ norm. In this paper we develop a Momentumized Iterative Shrinkage Thresholding (MIST) algorithm for minimizing the resulting non-convex criterion and prove its convergence to a local minimizer. Simulations on large data sets show superior performance of the proposed method to other methods.

Published
2014

11. L0 Sparse Inverse Covariance Estimation

Author

Marjanovic, Goran and Hero III, Alfred O.

Subjects
Statistics - Machine Learning
Abstract

Recently, there has been focus on penalized log-likelihood covariance estimation for sparse inverse covariance (precision) matrices. The penalty is responsible for inducing sparsity, and a very common choice is the convex $l_1$ norm. However, the best estimator performance is not always achieved with this penalty. The most natural sparsity promoting "norm" is the non-convex $l_0$ penalty but its lack of convexity has deterred its use in sparse maximum likelihood estimation. In this paper we consider non-convex $l_0$ penalized log-likelihood inverse covariance estimation and present a novel cyclic descent algorithm for its optimization. Convergence to a local minimizer is proved, which is highly non-trivial, and we demonstrate via simulations the reduced bias and superior quality of the $l_0$ penalty as compared to the $l_1$ penalty.

Published
2014
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13. GAUCHER DISEASE TYPE 1 AND GASTRIC CANCER: A CASE REPORT.

Author

Golubović, Ivana, Vučić, Miodrag, Marjanović, Goran, Ćojbašić, Irena, Nikolić, Vesna, Krstić, Miljan, Lazarević, Milan, Bojanović, Aleksandar, Stamenković, Bojana, Mladenović, Andrijana, Bjelaković, Milica, and Janković, Miloš

Subjects
GAUCHER'S disease, ENZYME replacement therapy, GASTRIC diseases, STOMACH cancer, CENTRAL nervous system
Abstract

Copyright of Acta Medica Medianae is the property of Acta Medica Medianae and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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19. Einfluss verschiedener Mengen an kristalloiden Infusionslösungen auf die Stabilität enteraler Anastomosen im Kleintiermodell

Author

Marjanovic, Goran, Villain, C., Höppner, J., Jüttner, E., Hopt, U. T., Obermaier, R., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
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27. FROM INBORN ERRORS OF IMMUNITY TO LYMPHOMA – A HEMATOLOGIST’S POINT OF VIEW.

Author

MARJANOVIĆ, Goran, DŽOPALIĆ, Tanja, KOSTIĆ, Miloš, LAZAREVIĆ, Milan, STOJANOSKI, Zlate, and BONAČI NIKOLIĆ, Branka

Subjects
*DNA repair, *COMMON variable immunodeficiency, *BISPECIFIC antibodies, *STEM cell transplantation, *HODGKIN'S disease, *PURE red cell aplasia, *DIFFUSE large B-cell lymphomas
Abstract

After infections, malignancies, lymphomas especially, are the second most frequent cause of death in patients with inborn errors of immunity. Factors predetermining the appearance and aggressiveness of lymphomas include gene defects, defects of immune surveillance and regulation as well as infections with oncogenic viruses. Aggressive non-Hodgkin lymphomas, mostly diffuse large B-cell and Bukit subtypes are predominant in deoxyribonucleic acid repair defects, while Hodgkin lymphoma becomes equally present in patients with defects of immune regulation. Marginal zone and mucosa-associated lymphoid tissue lymphomas, appear to be frequent in defects of antibody production, especially in patients with common variable immune deficiency. The prevalence of Epstein-Barr virus may vary within entities, but there is no entity without at least a few cases of lymphoma and Epstein-Barr virus co-infection. Standard treatment of lymphomas associated with deoxyribonucleic acid repair defects and severe combined deficiencies, is stem cell transplantation. Lymphomas in inborn errors of immunity with a less severe clinical presentation, should be treated with immunochemotherapy and monoclonal antibodies (Brentuximab, Rituximab) wherever feasible. There is no data about the usefulness of checkpoint inhibitors, bi-specific antibodies and T-cells with chimeric antigen receptor. Allogeneic stem cell transplantation represents a major indication for treatment of relapse/refractory lymphomas in any inborn error of immunity. Potential benefit of therapy with Chimeric antigen receptor Natural-killer cells in lymphomas associated with inborn errors of immunity, remains to be seen in future studies. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Follicular lymphoma incidence and mortality in relation to overweight, obesity and physical activity: A meta-analysis

Author

Golubović, Ilija, Marjanović, Goran, Radojković, Danijela, Sokolović, Dušan, Karanikolić, Aleksandar, Radojković, Milan, and Pavlović, Milorad

Subjects
meta-analysis, obesity, follicular lymphoma, overweight, physical activity
Abstract

In the last few years, there has been a growing interest in exploring the association between risk factors such as overweight, obesity and physical activity, and incidence of various cancers. Meta-analysis was performed to investigate the risk ratio of follicular lymphoma incidence and mortality in overweight and obese individuals, and in individuals with a different physical activity levels using the random-effects model. A literature search through September 2016 was performed. Case-control studies accounted for over 2.100 cases and 12.700 controls, whereas cohort studies accounted for over 2.600 cases in cohort of about 3.000.000 individuals. In overweight individuals (body mass index between 25 and 29.99 kg/m2) risk ratio for the development of follicular lymphoma was 1.03 (0.95-1.11; 95% CI; p = 0.51) and in obese (body mass index ≥ 30 kg/m2) it was 1.15 (1.01-1.31; 95% CI; p = 0.04) when compared to individuals with normal body mass index (< 25 kg/m2). The risk ratio of specific follicular lymphoma mortality in overweight was 0.59 (0.38-0.91; 95% CI; p = 0.02), while in obese patients it was 1.08 (0.68-1.71; 95% CI; p = 0.75). In patients with the highest physical activity levels, the risk ratio for follicular lymphoma occurrence was 0.95 (0.75-1.21; 95% CI; p = 0.68) when compared to patients that had the lowest physical activity levels. In summary, our meta-analysis has shown statistically significant direct association between obesity and follicular lymphoma incidence.

Published
2018

30. Značaj galektina-1 kao prognostičkog faktora u lečenju klasičnog Hočkinovog limfoma

Author

Marjanović, Goran, Mačukanović-Golubović, Lana, Jevtović-Stoimenov, Tatjana, Mihaljević, Biljana, Simonović, Olivera B., Marjanović, Goran, Mačukanović-Golubović, Lana, Jevtović-Stoimenov, Tatjana, Mihaljević, Biljana, and Simonović, Olivera B.

Abstract

In classical Hodgkin’s lymphoma (cHL) the existing prognostic scoring systems do not include markers that adequately reflect the interaction of malignant Hodgkin and Reed-Sternberg (HRS) cells and tumor environment. The research objective is to determine the relationship between serum Galectin-1 (Gal-1) and soluble CD163 (sCD163) and the clinical status of patients with cHL, with special emphasis on the presence of relapse, progression, or resistance to the therapy applied. The research included 79 patients. Of this number, 63 were patients with cHL, and the control group consisted of 16 healthy volunteers. The study group of 63 patients with cHL included a subgroup of newly diagnosed patients without therapy, newly diagnosed patients with therapy, patients with relapse and progression of the disease, and primary refractory patients during 2014 and 2015. Analysis of the levels of sCD163 and sGal-1 within a group of patients suffering from cHL has shown that the values of both molecules were higher in relapsed patients and the subgroup with progressive disease comparing the subgroup of newly diagnosed patients without therapy or patients with therapy onset. Determination of Gal-1 and sCD163 levels is simple and reliable analysis that can contribute to the identification of high-risk patients with cHL, and deserves inclusion in current prognostic scoring systems.

Published
2018

31. Značaj inflamatornih markera i poremećaja sistema hemostaze kod bolesnika sa akutnim pankreatitisom

Author

Radovanović-Dinić, Biljana, Nagorni, Aleksandar, Marjanović, Goran, Jevtović Stimenov, Tatjana, Đuranović, Srđan, Tešić Rajković, Snežana K., Radovanović-Dinić, Biljana, Nagorni, Aleksandar, Marjanović, Goran, Jevtović Stimenov, Tatjana, Đuranović, Srđan, and Tešić Rajković, Snežana K.

Abstract

A possibility to develop sever systemic complications of acute pancreatitis(AP) demands timely assessment of the severity of the disease in order to make an optimal therapeutic approach and a correct prognosis of the disease. The aim of the study was to establish the role of certain individual inflammatory biomarkers and coagulation parameters in the prediction of AP severity, and also to propose a mathematical formula which allows there combined use for the same purpose. Methods. The prospective study included 92 patients with AP. The patients were divided into groups: mild, moderate and severe AP. Results. Based on the results of Mann-Whitney,s test, it can be concluded that a statistically significant difference between groups A(mild) and B(moderate and severe) for CRP (p<0.05). Using the Wald’s stepwise forward method, a prediction model with CRP, PCT, D-dimer 1, D-dimer 3, fibrinogen 1 and fibrinogen 3 parameters as predictors of the severity of AP has been obtained. The percentage of successful prediction of moderate or severe AP based on this model is 76.9%. Conclusion. The combined analysis of biohumoral markers and coagulation parameters presented in the form a mathematical formula can enable a more accurate, rapid, rational and clinically available prediction of the severity of AP.

Published
2018

32. Archaeoacoustic analysis of Kanda Hill in Macedonia. Study of the peculiar EM phenomena and audio frequency vibrations

Author

Debertolis, Paolo, Nikolić, Domagoj, Marjanović, Goran, Savolainen, Heikki, Earl, Nina, Ristevski, Nikola, ARSA (Advanced Research in Scientific Areas), Debertolis, Paolo, Nikolić, Domagoj, Marjanović, Goran, Savolainen, Heikki, Earl, Nina, and Ristevski, Nikola

Subjects
archaeoacoustics, geoglyph, EM waves, archaeoacoustic
Abstract

Archaeoacoustic and Electromagnetic research of ancient sites is becoming an established discipline. SB Research Group (SBRG) have been developing a new methodology over the last five years using a practical archaeoacoustic standard (SBSA), which helps to explain certain phenomena which are commonly found at “sacred sites”. Applying this expertise enabled better understanding of the specific EM and acoustic wave emissions present on Kanda Hill, Macedonia. Analyzing these emissions enables better understanding of what lies below the surface. The previous research paper (ARSA 2014) demonstrated evidence of various physical phenomena present at this ancient site and the artificial origin of this hill, which should now be reffered to as a tumulus. At the time of writing the presence of interior cavities in was suspected, possibly consisting of small number of chambers and passageways. This hypothesis is corroborated by the evidence presented in this paper.

Published
2015

36. Archaeoacoustic analysis of Kanda Hill in Macedonia

Author

Debertolis, Paolo, Nikolić, Domagoj, Marjanović, Goran, Savolainen, Heikki, and Ristevski, Nikola

Subjects
archaeoacoustics, geoglyph, EM waves
Abstract

Archaeoacoustic and Electromagnetic research of ancient sites is becoming an established discipline. SB Research Group (SBRG) have been developing a new methodology over the last five years using a practical archaeoacoustic standard (SBSA), which helps to explain certain phenomena which are commonly found at “sacred sites”. Applying this expertise enabled better understanding of the specific EM and acoustic wave emissions present on Kanda Hill, Macedonia. Analyzing these emissions enables better understanding of what lies below the surface. The previous research paper (ARSA 2014) demonstrated evidence of various physical phenomena present at this ancient site and the artificial origin of this hill, which should now be referred to as a tumulus. At the time of writing the presence of interior cavities in was suspected, possibly consisting of small number of chambers and passageways. This hypothesis is corroborated by the evidence presented in this paper.

Published
2015

37. Klinički i imunološki faktori prognoze kod bolesnika sa B difuznim krupnoćelijskim nehočkinskim limfomom

Author

Marjanović, Goran, Mačukanović-Golubović, Lana, Jevtović-Stoimenov, Tatjana, Krstić, Miljan, Đurđević, Predrag, Tadić, Ljiljana Lj., Marjanović, Goran, Mačukanović-Golubović, Lana, Jevtović-Stoimenov, Tatjana, Krstić, Miljan, Đurđević, Predrag, and Tadić, Ljiljana Lj.

Abstract

Patients with diffuse large B cell non Hodgkin lymphoma (DLBCL) have a very heterogeneous clinical course and prognosis. There is a constant need to find new prognostic factors to assess risk in patients. Immunohistochemical biomarkers correlated with clinical and biochemical parameters, as well as prognostic scores may be predictors of risk patients. The main aim of this study was to analyze the survival of patients with diffuse large B- cell non Hodgkin lymphoma according to clinical prognostic factors and expression of proteins involved in the activation of immune response, cell cycle regulation and programmed cell death (Ki-67, Bcl-2, Bcl-6 , CD10, CD5, CD138, MUM1 and the presence of mutations L265P MyD88), by classifying patients according to current prognostic scoring systems comparing the clinical and immunological factors prognosis in patients with DLBCL, make a proposal for a prognostic scoring system that would unite the two groups of parameters. All patients was determined by clinical stage of the disease. During the study were collected and processed by clinical and laboratory parameters, that are known to have a prognostic value and that it was possible to collect for all patients included in the study. It is about gender, age, Ann Arbor clinical stage of disease, extranodal number of cities affected processes, performance status, presence of "B" symptoms, hemoglobin, platelet count, erythrocyte sedimentation rate, C-reactive protein levels, beta 2 microglobulin, serum albumin and serum LDH. Histopathological material consisted of 68 paraffin blocks. From immunohistochemical parameters were analyzed: CD5, CD10, Ki- 67, Bcl-2, Bcl-6, MUM1 by EnVision procedure. Molecular-genetic study of gene polymorphism MyD88 L265P was used genomic DNA isolated from fixed tissue in paraffin patients with DLBCL. Polymerization chain reaction were amplified by DNA segments within which the SNP is tested gene MyD88 L265P. Statistical analyzes included the use of nonparam

Published
2016

38. Archaeoacoustic analysis of the ancient site of Kanda (Macedonia). Preliminary results

Author

Debertolis, Paolo, Tentov, Aristotel, Nikolić, Domagoj, Marjanović, Goran, and Savolainen, Heikki, Earl, Nina

Subjects
archaeoacustics, geoglyph, Kanda, Sveti Nikole, Macedonia, brain activity
Abstract

Research was carried out on a geoglyph located in Kanda (Macedonia) by an international team using interdisciplinary methods (astronomy, philosophy, mythology, mathematics and physics). The research conducted on two occasions in 2014 was undertaken to establish all potential anomalies in the IS, US and EM spectrum with special attention to anomalies common to sacred sites, but as yet unexplained by standard physics. We conclude the Geoglyph looks to be built on an artificial hill. This hill or mound also appears to be artificial from the aeroplane. The Geoglyph is visible only from the sky and is located in an oval ditch. Some measurements suggest that there is chamber located below the surface. Research by different methods (infra-/ultrasound research, AMT measurements, binary algorithm synthesis from audio waves, data sonification and dowsing) also found that at the sacred enclosure primary water is located at the centre or at some point along its major axis. Furthermore, since the soil does not match the surrounding area, it would certainly appear that this mound has been carefully constructed with a specific purpose in mind. What exactly that purpose is remains to be investigated in future

Published
2014

39. Prednosti upotrebe biotehnološkog postupka produkcije interferona-gama iz prečišćene suspenzije humanih leukocita

Author

Kamenov, Borislav, Marjanović, Goran, Kocić, Gordana, Stanković-Đorđević, Dobrila, Romić, Marija, Stanković, Bratislav P., Kamenov, Borislav, Marjanović, Goran, Kocić, Gordana, Stanković-Đorđević, Dobrila, Romić, Marija, and Stanković, Bratislav P.

Abstract

Interferons (IFN) are first described in the late fifties of the twentieth century as special proteins in the family of cytokines and induced by the host, after invasion virus. If you are transferred to the fresh tissue was observed antiviral activity, thanks to inhibit replication of the virus. In this appearance immunology known as "interference". Under normal conditions in the human body concentration of IFN-a was below detectable levels or because cells synthesize IFN or contain as its constituent element. IFN was divided in three classes: IFN-, IFN- and IFN-. Most mammalian cells formed in unequal quantities of IFN- and IFN- after stimulation with viruses or other agents, or inducers of the synthesis of IFN. In many countries, is still detained biotechnological process for the production of human IFN (hlFN) for the clinical application of human leukocytes allocated from canned whole blood units, not older than 6 hours. After centrifugation the procedure centrifugation devotes a buffy coat (leukocyte suspension) as a "side" -produkat. Further processing of "buffy coat" (BC) was purified from the red cell contamination, in order to obtain as pure substrate of human leukocytes, which is subjected to viral infection in order to stimulate the synthesis of hIFN-. Different viruses are used as inductors synthesis hIFN-, but in practice most often used "Sendai" virus, cultivated in horion-alantoic membrane of chicken embryos. Induction of synthesis hIFN- played on temperature of +37 ° C and lasts 18 hours. Refined suspension of human tal and practical. In fundamental respects got the time sequence data on the morphology, viability and induction capabilities of leucocytes, or their ability under the influence of the inductor synthesis hIFN- (or lyophilized virus hemagglutinin) higher yields of interferon, in the new proposed terms. In practical terms should consolidate that, when using a total amount of BC and from all transfusion centers in the Republic of Ser

Published
2015

41. Klinički i morfometrijski pokazatelji terapijskog odgovora kod hronične mijeloidne leukemije

Author

Mačukanović-Golubović, Lana, Popović, Stevan, Mihailović, Dragan, Marjanović, Goran, Vučić, Miodrag, Ćojbašić, Irena, Mačukanović-Golubović, Lana, Popović, Stevan, Mihailović, Dragan, Marjanović, Goran, Vučić, Miodrag, and Ćojbašić, Irena

Abstract

PURPOSE: Research aim of this dissertation is to examine and determine the rates of cytogenetic and molecular responses in patients with chronic myeloid leukemia as well as identification of clinical and laboratory parameters that influence clinical course of the disease and achievement of complete cytogenetic and major molecular response to therapy. Also, the goal of this dissertation is determination and comparison of the basic morphometric parameters of bone marrow angiogenesis for studied groups of patients in order to prove the difference in the degree of angiogenesis, as well as identification of prognostic morphometric parameters of angiogenesis affecting the achievement of complete cytogenetic and major molecular responses. Thesis also includes development and comparison of regression predictive models in which single morphometric parameters of angiogenesis were added to the basic clinical parameters in order to increase the accuracy of prediction of complete cytogenetic and major molecular responses to therapy. METHODOLOGY: This research included 40 patients with chronic myeloid leukemia Philadelphia positive in chronic phase and 20 patients with Hodgkin's and non-Hodgkin's lymphoma in which there was no evidence of lymphoma infiltration of the bone marrow, which were treated at the Clinic of Hematology and Clinical Immunology of the Clinical Center Niš. Morphometric analysis of the microvascular structure of the bone marrow has been performed on biopsy specimens of all patients. Immunohistochemical CD34 stained microscopic preparations have been analyzed on Leica DMR microscope with a digital camera using the direct digitization. Quantification of the digital images was performed using software (ImageJ software, National Institutes of Health, USA) on a personal computer. Firstly total number of microvascular structures by optical field has been determined. For every countable microvascular structure that has been identified, the size dependent and shape de

Published
2014

42. Interakcija Th-17 imunskog odgovora i glutamatske ekscitotoksičnosti u patogenezi multiple skleroze : klinička i eksperimentalna studija

Author

Čolić, Miodrag, Stojanović, Ivana, Vojinović, Slobodan, Marjanović, Goran, Obradović, Dragana, Kostić, Miloš S., Čolić, Miodrag, Stojanović, Ivana, Vojinović, Slobodan, Marjanović, Goran, Obradović, Dragana, and Kostić, Miloš S.

Abstract

Introduction: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) characterized by episodic neurological defects, disseminated in time and neuroanatomical localization. The central role in the development of inflammatory mediated lesions in MS is now attributed to autoreactive, myelin-specific CD4+ T lymphocytes, which are thought to regulate all immune mechanisms that lead to the myelin sheath damage. It was originally thought that these cells belong to the subpopulation of Th-1 cells, however, a number of nowadays studies indicate the importance Th-17 cells in the pathogenesis of the disease. In addition to demyelination, which is still considered to be the main pathological feature of the disease, in the last few years special attention in MS research has been given to neurodegenerative processes, considering that it has been shown that the clinical symptoms of the disease are directly related to the degree of axonal damage and loss. Recently, glutamate excitotoxicity is considered as a possible mechanism of neurodegeneration in MS. This is a phenomenon that occurs when the excessive amount of excitatory neurotransmitter glutamate, overactivates its receptors on the membranes of neurons and oligodendrocytes, which leads to the intracellular accumulation of Ca2+ ions and the consequent cell death. Aims of the Thesis: To examine the association of Th-17 mediated inflammation and glutamate excitotoxicity in the development of MS. To determine the potential molecular mechanisms by which inflammation stimulates glutamate excitotoxicity and the consequent neurodegeneration with special emphasis on the role of astrocytes. Materials and Methods: The study had two integral parts: a clinical part conducted on the human material and experimental part conducted on the primary cultures of rat astrocytes. The clinical study enrolled 79 patients, divided into two groups: a control group and a group of MS patients. The presence of a Th

Published
2014

43. Transformationlaender - Subjekte oder Objekte der Europaeischen Integrationen

Author

Penavin, Stipan, Marjanović, Goran, Dabić, Stanko, Marijanović, Goran, and Wentzel Dirk

Subjects
Eurpaeische Union, Integration, Transformationlaender, Entwicklung, Kapital, Investition
Abstract

Der Beginn der Integration der europaeische Staa-ten in einen gemeinsamen politischen und wirt-schaftlichen Raum stelt eines der bedeutendsten Orojekt in modernen Geschichte dar. Im Unterschi-ed zu der Vielzahl von Versuchen in der fruehen, aber auch juengeren Geschichte, den europaei-schen Raum zu integrieren, was ueberwiegend auf militaerischem Wege vonstatten ging und der Re-gel fehlschlug, beruht die Schaffung der Europae-ischen Union auf voellig anderen Grundlagen. Dies sind Grundagen, die von den gemeinsam Inte- ressen alles Mitgliedlaender der Union ausgehen solten und von der Gleichberichtungung aller Mitgieder in ihren gegenseitigen Bezihungen geke-nnzeichnet sollten. Es ist verstaendlich, dass eine solche Platform den eurpaeische Integration- sprozess sehr attraktiv macht und dass die Mehr-zahl der euroaeischen Staaten daran aktiv teil-haben moechte. Die Probleme, die im Laufe des europaeischen Integrationprozess auftreten und die warscheinlic am staerksten zum Ausdruck kom-men, sind die Unerschiede im Entwicklungsstand der demokratischen und der gesellschaftlichen Be-ziehungen zwischen den Mitgliedslaendern, in erster Reihe zwischen den so genannten westeeuropaeischen und den Transformationlaen-dern. Es stellt sich die Frage. ob in solchen Bedingungen die weniger fortgeschrittenen Laen-der tatsaechlich oder lediglich formell in die Union integriert sind, bzw. ob sie das Subjekt oder das objekt der Integration sind. Diese Ar-beit vertritt den Standpunkt, dass die Transformationslaender, die entweder bereits Mit-glied der Union sind oder es in Kuerze sein wer-den, formell zwar integriert sind, aber nicht auch faktisch, Solange sie die gesellschaftli-chen Prozesse in der Union nicht zu beeinflussen in der Lage sind wie es die entwickelten Mitgli-edslaender tun, Koennen sie nicht Subjekte der Integration sein, sondern nur die Objekte. Eine der folgenschweren Konsequenzen einer solchen Lage koennte die objektive Bedrohung darstellen, dass es in der Europaeischen Union zu einem bes-timmten Entwicklungsdualismus kommt, bzw.dass sich in der Union zwei unterschiedliche Entwick-lungszonen profilieren: eine fortgeschrittene, in der sich die Laender des bisherigen Westeuro-pas befinden, und eine weniger entwickelte, in der die Transformationslaenders sind. Ausgehend von den oben erwaehnten Tatsachen, draengt sich die Frage auf, ob die Europaeische Union in "diesen darart defierten zwei Gaengen fahren" kann. Die Warscheinlichste Antwort ist womoeg-lich bajahend, aber nur kurzfristig. Andernfalls wird sich die Union mit Problemen auseinander setzen muessen, die in jenen Laendern wohlbekan-nte sind, in denen ein grosses regionales Entwi-cklungsgefaelle existiert. In dieser Arbeit werdwn einige Gedanken behandelt, wie die Union diese Probleme ueberwinden koennte.

Published
2007

44. Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells

Author

Jevtovic-Stoimenov, Tatjana, Kocić, Gordana, Pavlović, Dušica, Macukanović-Golubović, Lana, Marjanović, Goran, Đorđević, Vidosava, Tošić, Nataša, Pavlović, Sonja, Jevtovic-Stoimenov, Tatjana, Kocić, Gordana, Pavlović, Dušica, Macukanović-Golubović, Lana, Marjanović, Goran, Đorđević, Vidosava, Tošić, Nataša, and Pavlović, Sonja

Abstract

Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) have been shown to play an important role in the pathogenesis of limphoproliferative disease. Both cytokines regulate cell-survival and cell-death in leukemic cells. TNF-alpha and LT-alpha are highly produced in chronic lymphotic leukemia (CLL) and non-Hodgkin lymphoma (NHL) patients. Genetic polymorphism within regulatory regions of these cytokine genes can alter their expression levels. This study investigates an influence of TNF-alpha - 308 and LT-alpha + 250 polymorphisms on the activity of alkaline DNase in mononuclear cells of both patient groups as a potent biochemical marker of DNA fragmentation in the terminal phase of apoptosis. Study was performed on mononuclear cells of CLL and NHL patients. SNP were obtained by PCR-RFLP method. The activity of alkaline DNase was measured by spectrophotometric method. The study provided evidence of the influence of TNFG/A genotype and A alleles in the susceptibility to NHL, since the association of LT-alpha G/G genotype with CLL was observed. High-producing TNF-alpha - 308/LT-alpha + 250 heterozygous haplotype is associated with high NHL incidence. The investigated SNP influence the activity of alkaline DNase in CLL and NHL patients. The observed polymorphisms may modulate susceptibility of leukemic cells to apoptosis by way of DNase activity.

Published
2008

45. PRIPREMA PACIJENATA SA HEMOFILIJOM A ZA ORALNOHIRURŠKE INTERVENCIJE.

Author

Tijanić, Ivan, Vučić, Miodrag, Mačukanović-Golubović, Lana, Marjanović, Goran, Burić, Nikola, and Tijanić, Miloš

Abstract

Copyright of Acta Stomatologica Naissi is the property of Clinic of Stomatology Nis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2015
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46. Hyperlymphocytosis in a Patient with T-prolymphocytic Leukemia Not Responding to Therapy: Case Report.

Author

Marjanović, Goran, Nikolić, Vesna, Vukićević, Tomislav, Golubović, Lana Mačukanović, and Drašković, Dragana

Subjects
LEUKEMIA, LEUCOCYTES, DRUG therapy, CANCER chemotherapy, T cells, CANCER treatment, ADULT T-cell leukemia
Abstract

Copyright of Acta Facultatis Medicae Naissensis is the property of Nis University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011

47. Palpable Lymphadenopathy in Primary Care.

Author

Lukić, Stefan, Marjanović, Goran, and Živanović, Jovana

Subjects
PRIMARY care, DIAGNOSIS, THERAPEUTICS, EMPIRICAL medicine, ANTIBIOTICS, ADRENOCORTICAL hormones
Abstract

Copyright of Acta Facultatis Medicae Naissensis is the property of Nis University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011

48. Cord Blood Transplantation in Adult Patients With Hematological Malignancies.

Author

Marjanović, Goran, Todorović-Bakrač, Milena, and Jevtović-Stoimenov, Tatjana

Subjects
UMBILICAL cord, STEM cell transplantation, HEMATOLOGY, BONE marrow, ETHNICITY, LEUCOCYTES
Abstract

Copyright of Acta Facultatis Medicae Naissensis is the property of Nis University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2010

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