40 results on '"Mariuz M."'
Search Results
2. Impact of methylmercury and other heavy metals exposure on neurocognitive function in children aged 7 years: Study protocol of the follow-up
- Author
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Brumatti, L. V., Rosolen, V., Mariuz, M., Piscianz, E., Valencic, E., Bin, M., Athanasakis, E., D'Adamo, P., Fragkiadoulaki, E., Calamandrei, G., Dinckol, O., Barbone, F., and Ronfani, L.
- Subjects
Developmental disorder ,Heavy metal toxicity ,Mercury toxicity ,Schooling age ,Adult ,Animals ,Child ,Child, Preschool ,Diet Surveys ,Female ,Fishes ,Follow-Up Studies ,Food Contamination ,Hair ,Humans ,Infant ,Italy ,Male ,Metals, Heavy ,Methylmercury Compounds ,Neurodevelopmental Disorders ,Pregnancy ,Prospective Studies ,Maternal Nutritional Physiological Phenomena ,Prenatal Exposure Delayed Effects - Published
- 2021
3. AMP Deaminase from Necrotic Rat Heart
- Author
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Żydowo, Mariuz M., Walentynowicz, Olga, Wrzołkowa, Teresa, De Bruyn, Chris H. M. M., editor, Simmonds, H. Anne, editor, and Müller, Mathias M., editor
- Published
- 1984
- Full Text
- View/download PDF
4. Environmental indicators in EpiAir2 project: Air quality data for epidemiological surveillance [Indicatori ambientali nello studio EpiAir2: I dati di qualità dell'aria per la sorveglianza epidemiologica]
- Author
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Gandini, M., Berti, G., Cattani, G., Faustini, A., Scarinzi, C., Donato, F., Accetta, G., Angiuli, L., Caldara, S., Carreras, G., Casale, P., Di Biagio, K., Giannini, S., Iuzzolino, C., Lanzani, G., Lauriola, P., Leuci, P., Mariuz, M., Marchesi, S., Nocioni, A., Pistollato, S., Pizzi, L., Ranzi, A., Serinelli, M., Stagnaro, E., Vianello, L., Vigotti, M., Zauli-Sajani, S., Cadum, E., Alessandrini, E. R., Angelini, P., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Biggeri, A., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Casale, G., Casella, C., Casetta, A., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Girolamo, G., Togni, A., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Forastiere, F., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., La Torretta, T., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Mariottini, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nuvolone, D., Onorati, R. N. G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scondotto, S., Selle, V., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Massimo Stafoggia, Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.
- Published
- 2013
5. Indicatori ambientali nello studio EpiAir2: i dati di qualità dell’aria per la sorveglianza epidemiologica. [Environmental indicators in EpiAir2 project: air quality data for epidemiological surveillance]
- Author
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Gandini, M, Berti, G, Cattani, G, Faustini, A, Scarinzi, C, DE DONATO, F, Accetta, G, Angiuli, L, Caldara, S, Carreras, G, Casale, P, DI BIAGIO, K, Giannini, S, Iuzzolino, C, Lanzani, G, Lauriola, P, Leuci, P, Mariuz, M, Marchesi, S, Nocioni, A, Pistollato, S, Pizzi, L, Ranzi, A, Serinelli, M, Stagaro, E, Vianello, L, Vigotti, Ma, ZAULI SAJANI, S, Cadum, E, GRUPPO COLLABORATIVO EPIAIR2, and Vercelli, Marina
- Subjects
environmental indicators ,epidemiological surveillance - Published
- 2013
6. AMP Deaminase from Necrotic Rat Heart
- Author
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Mariuz M. Żydowo, Teresa Wrzołkowa, and Olga Walentynowicz
- Subjects
chemistry.chemical_classification ,Liposome ,Adenylate deaminase ,Skeletal muscle ,AMP deaminase ,Rat heart ,chemistry.chemical_compound ,medicine.anatomical_structure ,Enzyme ,chemistry ,Biochemistry ,Phosphatidylcholine ,medicine ,Enzyme kinetics - Abstract
Adenylate deaminase isolated from the heart was shown to be regulated in a special way by phosphatidylcholine containing liposomes /Purzycka-Preis et al. 1978/. While the liposomes had no effect on the enzyme kinetics in the absence of ATP, the ATP-activated adenylate deaminase displayed a V-type activation under the influence of the liposomes. This effect of liposomes was observed with the enzyme isolated both from the pig /Purzycka et al. 1978/ and rat heart /Żydowo et al. 1980/, from several other rat tissues /Prus et al. 1980/ not however from skeletal muscle.
- Published
- 1984
7. Policies for the promotion of sustainable mobility and the reduction of traffic-related air pollution in the cities participating in the EpiAir2 project,Le politiche per la promozione della mobilità sostenibile e la riduzione dell'inquinamento atmosferico causato dal traffico veicolare nelle città partecipanti allo studio EpiAir2
- Author
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Di Lonardo, S., Nuvolone, D., Forastiere, F., Cadum, E., Barchielli, A., Accetta, G., Alessandrini, E. R., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baccini, M., FLAVIA BALDACCHINI, Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Biggeri, A., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Caldara, S., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Carreras, G., Casale, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Lauriola, P., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Ranzi, A., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Selle, V., Serinelli, M., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Stagnaro, E., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., Zauli-Sajani, S., and Zero, F.
8. [Fetal and perinatal exposure to mercury and selenium: baseline evaluation of a cohort of children in Friuli Venezia Giulia, Italy]. | Esposizione fetale e perinatale a mercurio e selenio: valutazione alla baseline di una coorte di bambini del Friuli Venezia Giulia
- Author
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Francesca Valent, Pisa, F., Mariuz, M., Horvat, M., Gibicar, D., Fajon, V., Mazej, D., Daris, F., and Barbone, F.
9. Air pollution and urgent hospital admissions in 25 Italian cities: Results from the EpiAir2 project,Inquinamento atmosferico e ricoveri ospedalieri urgenti in 25 città Italiane: Risultati del progetto EpiAir2
- Author
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Scarinzi, C., Alessandrini, E. R., Chiusolo, M., Galassi, C., Baldini, M., Serinelli, M., Pandolfi, P., Bruni, A., Biggeri, A., Togni, A., Carreras, G., Casella, C., Canova, C., Randi, G., Andrea Ranzi, Morassuto, C., Cernigliaro, A., Giannini, S., Lauriola, P., Minichilli, F., Gherardi, B., Zauli-Sajani, S., Stafoggia, M., Casale, P., Gianicolo, E. A. L., Piovesan, C., Tominz, R., Porcaro, L., Cadum, E., Accetta, G., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Caldara, S., Calzolari, R., Canossa, E., Caramia, G., Casale, G., Casetta, A., Cattani, G., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Forastiere, F., Fruzzetti, R., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Mircea, M., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Protti, M., Puppo, A., Raciti, M., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scondotto, S., Selle, V., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stagnaro, E., Starnino, G., Stivanello, E., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.
10. [Environmental indicators in EpiAir2 project: air quality data for epidemiological surveillance]
- Author
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Gandini M, Berti G, Cattani G, Faustini A, Scarinzi C, De'donato F, Gabriele Accetta, Angiuli L, Caldara S, Carreras G, Casale P, Di Biagio K, Giannini S, Iuzzolino C, Lanzani G, Lauriola P, Leuci P, Mariuz M, Marchesi S, and Nocioni A
11. [Fetal and perinatal exposure to mercury and selenium: baseline evaluation of a cohort of children in Friuli Venezia Giulia, Italy]
- Author
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Valent F, Federica Edith Pisa, Mariuz M, Horvat M, Gibicar D, Fajon V, Mazej D, Daris F, and Barbone F
12. Air pollution and urgent hospital admissions in 25 Italian cities: Results from the EpiAir2 project | Inquinamento atmosferico e ricoveri ospedalieri urgenti in 25 città Italiane: Risultati del progetto EpiAir2
- Author
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Scarinzi, C., Alessandrini, E. R., Chiusolo, M., Galassi, C., Baldini, M., Serinelli, M., Pandolfi, P., Bruni, A., Biggeri, A., Togni, A., Carreras, G., Casella, C., Canova, C., Randi, G., Ranzi, A., Morassuto, C., Cernigliaro, A., Giannini, S., Lauriola, P., Minichilli, F., Gherardi, B., Zauli-Sajani, S., Stafoggia, M., Casale, P., Gianicolo, E. A. L., Piovesan, C., Tominz, R., Porcaro, L., Cadum, E., Accetta, G., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Fabio Barbone, Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Caldara, S., Calzolari, R., Canossa, E., Caramia, G., Casale, G., Casetta, A., Cattani, G., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Forastiere, F., Fruzzetti, R., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Mircea, M., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Protti, M., Puppo, A., Raciti, M., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scondotto, S., Selle, V., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stagnaro, E., Starnino, G., Stivanello, E., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.
13. Environmental indicators in EpiAir2 project: Air quality data for epidemiological surveillance,Indicatori ambientali nello studio EpiAir2: I dati di qualità dell'aria per la sorveglianza epidemiologica
- Author
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Gandini, M., Berti, G., Cattani, G., Faustini, A., Scarinzi, C., Donato, F., Accetta, G., Angiuli, L., Caldara, S., Carreras, G., Casale, P., Di Biagio, K., Giannini, S., Iuzzolino, C., Lanzani, G., Lauriola, P., Leuci, P., Mariuz, M., Marchesi, S., Nocioni, A., Pistollato, S., Pizzi, L., Ranzi, A., Serinelli, M., Stagnaro, E., Vianello, L., Vigotti, M., Zauli-Sajani, S., Cadum, E., Alessandrini, E. R., Angelini, P., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Biggeri, A., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Casale, G., Casella, C., Casetta, A., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Girolamo, G., Togni, A., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Forastiere, F., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., La Torretta, T., Ferdinando Luberto, Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Mariottini, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nuvolone, D., Onorati, R. N. G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scondotto, S., Selle, V., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.
14. Short-term impact of air pollution among Italian cities covered by the EpiAir2 project,Impatto a breve termine dell'inquinamento dell'aria nelle città coperte dalla sorveglianza epidemiologica EpiAir2
- Author
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Baccini, M., Biggeri, A., Accetta, G., Alessandrini, E. R., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Cadum, E., Caldara, S., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Carreras, G., Casale, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Francesca K. de'Donato, Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Forastiere, F., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Lauriola, P., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Ranzi, A., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Selle, V., Serinelli, M., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Stagnaro, E., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., Zauli-Sajani, S., and Zero, F.
15. Short-term impact of air pollution among Italian cities covered by the EpiAir2 project | Impatto a breve termine dell'inquinamento dell'aria nelle città coperte dalla sorveglianza epidemiologica EpiAir2
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Baccini, M., Biggeri, A., Accetta, G., Alessandrini, E. R., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Cadum, E., Caldara, S., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Carreras, G., Casale, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Forastiere, F., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Lauriola, P., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Fabrizio Minichilli, Mircea, M., Morassuto, C., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Ranzi, A., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Selle, V., Serinelli, M., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Stagnaro, E., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., Zauli-Sajani, S., and Zero, F.
16. Air pollution and mortality in twenty-five Italian cities: Results of the EpiAir2 Project,Inquinamento atmosferico e mortalità in venticinque città Italiane: Risultati del progetto EpiAir2
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Alessandrini, E. R., Faustini, A., Chiusolo, M., Stafoggia, M., Gandini, M., Demaria, M., Antonelli, A., Arena, P., Biggeri, A., Canova, C., Casale, G., Cernigliaro, A., Garrone, E., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Iuzzolino, C., Lauriola, P., Mariottini, M., Pasetti, P., Randi, G., Andrea Ranzi, Santoro, M., Selle, V., Serinelli, M., Stivanello, E., Tominz, R., Vigotti, M., Zauli-Sajani, S., Forastiere, F., Cadum, E., Accetta, G., Angelini, P., Angiuli, L., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Caldara, S., Calzolari, R., Canossa, E., Caramia, G., Carreras, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Ganzi, A., Gatti, G., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., La Torretta, T., Lanzani, G., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Rosa, M., Rubini, G., Sacco, F., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stagnaro, E., Starnino, G., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.
17. Policies for the promotion of sustainable mobility and the reduction of traffic-related air pollution in the cities participating in the EpiAir2 project | Le politiche per la promozione della mobilità sostenibile e la riduzione dell'inquinamento atmosferico causato dal traffico veicolare nelle città partecipanti allo studio EpiAir2
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Di Lonardo, S., Nuvolone, D., Forastiere, F., Cadum, E., Barchielli, A., Accetta, G., Alessandrini, E. R., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Fabio Barbone, Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Biggeri, A., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Caldara, S., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Carreras, G., Casale, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Lauriola, P., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Ranzi, A., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Selle, V., Serinelli, M., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Stagnaro, E., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., Zauli-Sajani, S., and Zero, F.
18. Air pollution and mortality in twenty-five Italian cities: Results of the EpiAir2 Project | Inquinamento atmosferico e mortalità in venticinque città Italiane: Risultati del progetto EpiAir2
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Alessandrini, E. R., Faustini, A., Chiusolo, M., Stafoggia, M., Gandini, M., Demaria, M., Antonelli, A., Arena, P., Biggeri, A., Canova, C., Casale, G., Cernigliaro, A., Garrone, E., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Iuzzolino, C., Lauriola, P., Mariottini, M., Pasetti, P., Randi, G., Ranzi, A., Santoro, M., Selle, V., Serinelli, M., Stivanello, E., Tominz, R., Vigotti, M., Stefano Zauli Sajani, Forastiere, F., Cadum, E., Accetta, G., Angelini, P., Angiuli, L., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Caldara, S., Calzolari, R., Canossa, E., Caramia, G., Carreras, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Ganzi, A., Gatti, G., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., La Torretta, T., Lanzani, G., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Rosa, M., Rubini, G., Sacco, F., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stagnaro, E., Starnino, G., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.
19. The rapid spread of SARS-COV-2 Omicron variant in Italy reflected early through wastewater surveillance
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La Rosa, G., Iaconelli, M., Veneri, C., Mancini, P., Bonanno Ferraro, G., Brandtner, D., Lucentini, L., Bonadonna, L., Rossi, M., Grigioni, M., Suffredini, E., Giuseppe, Bucciarelli, Paolo, Torlontano, Giuseppe, Michele La Bianca, Rosa Anna Cifarelli, Achille, Palma, Giovanna La Vecchia, Giuseppe, Lauria, Rosanna, Brienza, Patrizia, Montenegro, Angelo, D'Argenzio, Luigi, Cossentino, Renato, Olivares, Antonio, Pizzolante, Giovanna, Fusco, Alessandra, Tosco, Amalia, Porta, Francesca, Pennino, Triassi, Maria, Paola, Angelini, Laura De Lellis, Daniele, Nasci, Giovanni, Alborali, Nicoletta, Formenti, Flavia, Guarneri, Nadia, Fontani, Giulia, Nani, Franca, Palumbo, Gianluca, Borlone, Marco, Guercio, Lisa, Gentili, Marika, Mariuz, Gabriella, Trani, Anna, Pariani, Carla, Ancona, Doriana Antonella Giorgi, Irene, Ferrante, Monica, Monfrinotti, Silvia, Riosa, Valeria, Capparuccini, Maria Teresa Scicluna, Antonella, Mariaconcetta, Arizzi, Giancarlo, Cecchini, Claudio, Ottaviano, Elena, Nicosia, Elena, Grasselli, Giorgia, Allaria, Alberto, Izzotti, Stefano, Rosatto, Emanuela, Ammoni, Danilo, Cereda, Marina Nadia Losio, Barbara, Bertasi, Andrea, Aliscioni, Desdemona, Oliva, Sara, Castiglioni, Silvia, Schiarea, Ettore, Zuccato, Manuela, Antonelli, Arianna, Azzellino, Francesca, Malpei, Andrea, Turolla, Sandro, Binda, Pellegrinelli, Laura, Valeria, Primache, Clementina, Cocuzza, Andrea, Franzetti, Giorgio, Bertanza, Maria Luisa Callegari, Luigi, Bolognini, Fabio, Filippetti, Marta, Paniccia, Francesca, Ciuti, Sara, Briscolini, Silvia, Magi, Michele, Colitti, Carmen, Montanaro, Giuseppe, Aprea, Maria Grazia Cerroni, Bartolomeo, Griglio, Renza, Berruti, Mauro, Cravero, Angela, Costa, Manila, Bianchi, Lucia, Decastelli, Angelo, Romano, Fabio, Zuccon, Elisabetta, Carraro, Cristina, Pignata, Silvia, Bonetta, Giuseppe Di Vittorio, Onofrio, Mongelli, Osvalda De Giglio, Francesca, Apollonio, Francesco, Triggiano, Maria Teresa Montagna, Nicola, Ungaro, Mario, Palermo, Carmelo Massimo Maida, Walter, Mazzucco, Simona De Grazia, Giovanni, Giammanco, Giuseppa, Purpari, Margherita, Ferrante, Antonella, Agodi, Martina, Barchitta, Piergiuseppe, Cala’, Carducci, Annalaura, Verani, Marco, Federigi, Ileana, Giulia, Lauretani, Sara, Muzio, Matteo, Ramazzotti, Alberto, Antonelli, Enrica, Ricci, Giovanni, Santoro, Ermanno, Federici, Maya, Petricciuolo, Sofia, Barigelli, Mauro, Ruffier, Francesca, Borney, Eric, Grange, Florida, Damasco, Francesca, Russo, Gisella, Pitter, Vanessa, Groppi, Franco, Rigoli, Marco, Zampini, Tatjana, Baldovin, Irene, Amoruso, Elena, Mengon, Maria, Cadonna, Mattia, Postinghel, Francesco, Pizzo, Alessandra, Schiavuzzi, Francesca, Cutrupi, Paola, Foladori, Serena, Manara, Lorella, Zago, Alberta, Stenico, Anna-Maria, Prast., La Rosa, G, Iaconelli, M, Veneri, C, Mancini, P, Bonanno Ferraro, G, Brandtner, D, Lucentini, L, Bonadonna, L, Rossi, M, Grigioni, M, Suffredini, E, Bucciarelli, G, Torlontano, P, Aprea, G, La Bianca, M, Cifarelli, R, Palma, A, La Vecchia, G, Lauria, G, Brienza, R, Montenegro, P, D'Argenzio, A, Cossentino, L, Olivares, R, Pizzolante, A, Fusco, G, Tosco, A, Porta, A, Pennino, F, Maria, T, Angelini, P, De Lellis, L, Nasci, D, Alborali, G, Formenti, N, Guarneri, F, Fontani, N, Nani, G, Palumbo, F, Borlone, G, Guercio, M, Gentili, L, Mariuz, M, Trani, G, Pariani, A, Ancona, C, Giorgi, D, Ferrante, I, Monfrinotti, M, Riosa, S, Capparuccini, V, Scicluna, M, Cersini, A, Arizzi, M, Cecchini, G, Ottaviano, C, Nicosia, E, Grasselli, E, Allaria, G, Izzotti, A, Rosatto, S, Ammoni, E, Cereda, D, Losio, M, Bertasi, B, Aliscioni, A, Oliva, D, Castiglioni, S, Schiarea, S, Zuccato, E, Antonelli, M, Azzellino, A, Malpei, F, Turolla, A, Binda, S, Laura, P, Primache, V, Cocuzza, C, Franzetti, A, Bertanza, G, Callegari, M, Bolognini, L, Filippetti, F, Paniccia', M, Ciuti, F, Briscolini, S, Magi, S, Colitti, M, Montanaro, C, Cerroni, M, Griglio, B, Berruti, R, Cravero, M, Costa, A, Bianchi, M, Decastelli, L, Romano, A, Zuccon, F, Carraro, E, Pignata, C, Bonetta, S, Di Vittorio, G, Mongelli, O, De Giglio, O, Apollonio, F, Triggiano, F, Montagna, M, Ungaro, N, Palermo, M, Maida, C, Mazzucco, W, De Grazia, S, Giammanco, G, Purpari, G, Ferrante, M, Agodi, A, Barchitta, M, Cala', P, Carducci, A, Verani, M, Federigi, I, Lauretani, G, Muzio, S, Ramazzotti, M, Antonelli, A, Ricci, E, Santoro, G, Federici, E, Petricciuolo, M, Barigelli, S, Ruffier, M, Borney, F, Grange, E, Damasco, F, Russo, F, Pitter, G, Groppi, V, Rigoli, F, Zampini, M, Baldovin, T, Amoruso, I, Mengon, E, Cadonna, M, Postinghel, M, Pizzo, F, Schiavuzzi, A, Cutrupi, F, Foladori, P, Manara, S, Zago, L, Stenico, A, Prast, A, La Rosa G., Iaconelli M., Veneri C., Mancini P., Bonanno Ferraro G., Brandtner D., Lucentini L., Bonadonna L., Rossi M., Grigioni M., Bucciarelli G., Torlontano P., Aprea G., La Bianca M., Cifarelli R.A., Palma A., La Vecchia G., Lauria G., Brienza R., Montenegro P., D'Argenzio A., Cossentino L., Olivares R., Pizzolante A., Fusco G., Tosco A., Porta A., Pennino F., Maria T., Angelini P., De Lellis L., Nasci D., Alborali G., Formenti N., Guarneri F., Fontani N., Nani G., Palumbo F., Borlone G., Guercio M., Gentili L., Mariuz M., Trani G., Pariani A., Ancona C., Giorgi D.A., Ferrante I., Monfrinotti M., Riosa S., Capparuccini V., Scicluna M.T., Cersini A., Arizzi M., Cecchini G., Ottaviano C., Nicosia E., Grasselli E., Allaria G., Izzotti A., Rosatto S., Ammoni E., Cereda D., Losio M.N., Bertasi B., Aliscioni A., Oliva D., Castiglioni S., Schiarea S., Zuccato E., Antonelli M., Azzellino A., Malpei F., Turolla A., Binda S., Laura P., Primache V., Cocuzza C., Franzetti A., Bertanza G., Callegari M.L., Bolognini L., Filippetti F., Paniccia' M., Ciuti F., Briscolini S., Magi S., Colitti M., Montanaro C., Cerroni M.G., Griglio B., Berruti R., Cravero M., Costa A., Bianchi M., Decastelli L., Romano A., Zuccon F., Carraro E., Pignata C., Bonetta S., Di Vittorio G., Mongelli O., De Giglio O., Apollonio F., Triggiano F., Montagna M.T., Ungaro N., Palermo M., Maida C.M., Mazzucco W., De Grazia S., Giammanco G., Purpari G., Ferrante M., Agodi A., Barchitta M., Cala' P., Carducci A., Verani M., Federigi I., Lauretani G., Muzio S., Ramazzotti M., Antonelli A., Ricci E., Santoro G., Federici E., Petricciuolo M., Barigelli S., Ruffier M., Borney F., Grange E., Damasco F., Russo F., Pitter G., Groppi V., Rigoli F., Zampini M., Baldovin T., Amoruso I., Mengon E., Cadonna M., Postinghel M., Pizzo F., Schiavuzzi A., Cutrupi F., Foladori P., Manara S., Zago L., Stenico A., Prast A.-M., Suffredini E., and Triassi, M
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Omicron ,RT-qPCR ,SARS-CoV-2 ,Sewage ,Variant ,Wastewater-based epidemiology ,Wastewater-Based Epidemiological Monitoring ,Environmental Engineering ,COVID-19 ,Wastewater ,Pollution ,Humans ,RNA, Viral ,Waste Water ,SARS-Cov2 ,Environmental Chemistry ,RNA ,Viral ,wastewater based epidemiology ,Waste Management and Disposal ,Human ,Omicron, RT-qPCR, SARS-CoV-2, Sewage, Variant, Wastewater-based epidemiology - Abstract
The SARS-CoV-2 Omicron variant emerged in South Africa in November 2021, and has later been identified worldwide, raising serious concerns. A real-time RT-PCR assay was designed for the rapid screening of the Omicron variant, targeting characteristic mutations of the spike gene. The assay was used to test 737 sewage samples collected throughout Italy (19/21 Regions) between 11 November and 25 December 2021, with the aim of assessing the spread of the Omicron variant in the country. Positive samples were also tested with a real-time RT-PCR developed by the European Commission, Joint Research Centre (JRC), and through nested RT-PCR followed by Sanger sequencing. Overall, 115 samples tested positive for Omicron SARS-CoV-2 variant. The first occurrence was detected on 7 December, in Veneto, North Italy. Later on, the variant spread extremely fast in three weeks, with prevalence of positive wastewater samples rising from 1.0% (1/104 samples) in the week 5-11 December, to 17.5% (25/143 samples) in the week 12-18, to 65.9% (89/135 samples) in the week 19-25, in line with the increase in cases of infection with the Omicron variant observed during December in Italy. Similarly, the number of Regions/Autonomous Provinces in which the variant was detected increased from one in the first week, to 11 in the second, and to 17 in the last one. The presence of the Omicron variant was confirmed by the JRC real-time RT-PCR in 79.1% (91/115) of the positive samples, and by Sanger sequencing in 66% (64/97) of PCR amplicons. In conclusion, we designed an RT-qPCR assay capable to detect the Omicron variant, which can be successfully used for the purpose of wastewater-based epidemiology. We also described the history of the introduction and diffusion of the Omicron variant in the Italian population and territory, confirming the effectiveness of sewage monitoring as a powerful surveillance tool.
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- 2022
20. Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels.
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Palir N, Stajnko A, Mazej D, France Štiglic A, Rosolen V, Mariuz M, Ronfani L, Snoj Tratnik J, Runkel AA, Tursunova V, Marc J, Prpić I, Špirić Z, Barbone F, Horvat M, and Falnoga I
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- Adult, Female, Humans, Infant, Newborn, Male, Pregnancy, Young Adult, Environmental Pollutants blood, Fetal Blood chemistry, Fetal Blood metabolism, Genotype, Maternal Exposure adverse effects, Risk Factors, Apolipoprotein E2 genetics, Lead blood
- Abstract
Lead (Pb) is a global contaminant associated with multiple adverse health effects. Humans are especially vulnerable during critical developmental stages. During pregnancy, exposure to Pb can occur through diet and release from maternal bones. Apolipoprotein E gene (APOE) variants (ɛ2, ɛ3, ɛ4 alleles) may influence sex steroid hormones, bone metabolism, and Pb kinetics. We examined the interplay among maternal APOE (mAPOE) genotypes, fetal sex, parity, and Pb in maternal and cord blood (mB-Pb, CB-Pb) using linear regression models. Our study involved 817 pregnant women and 772 newborns with measured adequate levels of zinc and selenium. We compared carriers of the ε2 and ε4 alleles to those with the ε3/ε3 genotype. The geometric means (range) of mB-Pb and CB-Pb were 11.1 (3.58-87.6) and 9.31 (1.82-47.0) ng/g, respectively. In cases with female fetuses, the maternal mAPOE ε2 allele was associated with higher, while the mAPOE ε4 allele was associated with lower mB-Pb and CB-Pb levels. Nulliparity increased the strength of the observed associations. These findings highlight the significance of mAPOE genetics, fetal sex, and parity in prenatal Pb kinetics. Notably, the maternal ε2 allele may increase the risk of Pb exposure., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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21. Publisher Correction: Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the "European Human Biomonitoring Initiative" HBM4EU participating studies.
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F Fernández S, Poteser M, Govarts E, Pardo O, Coscollà C, Schettgen T, Vogel N, Weber T, Murawski A, Kolossa-Gehring M, Rüther M, Schmidt P, Namorado S, Van Nieuwenhuyse A, Appenzeller B, Ólafsdóttir K, Halldorsson TI, Haug LS, Thomsen C, Barbone F, Mariuz M, Rosolen V, Rambaud L, Riou M, Göen T, Nübler S, Schäfer M, Zarrabi KHA, Sepai O, Martin LR, Schoeters G, Gilles L, Leander K, Moshammer H, Akesson A, and Laguzzi F
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- 2024
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22. Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the "European Human Biomonitoring Initiative" HBM4EU participating studies.
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F Fernández S, Poteser M, Govarts E, Pardo O, Coscollà C, Schettgen T, Vogel N, Weber T, Murawski A, Kolossa-Gehring M, Rüther M, Schmidt P, Namorado S, Van Nieuwenhuyse A, Appenzeller B, Ólafsdóttir K, Halldorsson TI, Haug LS, Thomsen C, Barbone F, Mariuz M, Rosolen V, Rambaud L, Riou M, Göen T, Nübler S, Schäfer M, Zarrabi KHA, Sepai O, Martin LR, Schoeters G, Gilles L, Leander K, Moshammer H, Akesson A, and Laguzzi F
- Subjects
- Adolescent, Humans, Adult, Child, Child, Preschool, Young Adult, Middle Aged, Creatinine, Biomarkers, Surveys and Questionnaires, Biological Monitoring, Acrylamide toxicity
- Abstract
Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014-2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3-18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20-45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences (β coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA (µg/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA:β = - 9.1 µg/g creatinine, 95% CI - 15.8, - 2.4; GAMA: β = - 3.4 µg/g creatinine, 95% CI - 4.7, - 2.2), living in rural areas (AAMA:β = - 4.7 µg/g creatinine, 95% CI - 8.6, - 0.8; GAMA:β = - 1.1 µg/g creatinine, 95% CI - 1.9, - 0.4) and increasing age (AAMA:β = - 1.9 µg/g creatinine, 95% CI - 2.4, - 1.4; GAMA:β = - 0.7 µg/g creatinine, 95% CI - 0.8, - 0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries., (© 2023. The Author(s).)
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- 2023
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23. Cognitive Performance and Exposure to Organophosphate Flame Retardants in Children: Evidence from a Cross-Sectional Analysis of Two European Mother-Child Cohorts.
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Rosolen V, Giordani E, Mariuz M, Parpinel M, Mustieles V, Gilles L, Govarts E, Rodriguez Martin L, Baken K, Schoeters G, Sepai O, Sovcikova E, Fabelova L, Kohoutek J, Jensen TK, Covaci A, Roggeman M, Melymuk L, Klánová J, Castano A, Esteban López M, and Barbone F
- Abstract
The knowledge of the effects of organophosphate flame retardants on children's neurodevelopment is limited. The purpose of the present research is to evaluate the association between exposure to organophosphate flame retardants and children's neurodevelopment in two European cohorts involved in the Human Biomonitoring Initiative Aligned Studies. The participants were school-aged children belonging to the Odense Child Cohort (Denmark) and the PCB cohort (Slovakia). In each cohort, the children's neurodevelopment was assessed through the Full-Scale Intelligence Quotient score of the Wechsler Intelligence Scale for Children, using two different editions. The children's urine samples, collected at one point in time, were analyzed for several metabolites of organophosphate flame retardants. The association between neurodevelopment and each organophosphate flame retardant metabolite was explored by applying separate multiple linear regressions based on the approach of MM-estimation in each cohort. In the Danish cohort, the mean ± standard deviation for the neurodevelopment score was 98 ± 12; the geometric mean (95% confidence interval (95% CI)) of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) standardized by creatinine (crt) was 0.52 µg/g crt (95% CI = 0.49; 0.60), while that of diphenyl phosphate (DPHP) standardized by crt was 1.44 µg/g crt (95% CI = 1.31; 1.58). The neurodevelopment score showed a small, negative, statistically imprecise trend with BDCIPP standardized by crt ( β = -1.30; 95%CI = -2.72; 0.11; p -value = 0.07) and no clear association with DPHP standardized by crt ( β = -0.98; 95%CI = -2.96; 0.99; p -value = 0.33). The neurodevelopment score showed a negative trend with BDCIPP ( β = -1.42; 95% CI = -2.70; -0.06; p -value = 0.04) and no clear association with DPHP ( β = -1.09; 95% CI = -2.87; 0.68; p -value = 0.23). In the Slovakian cohort, the mean ± standard deviation for the neurodevelopment score was 81 ± 15; the geometric mean of BDCIPP standardized by crt was 0.18 µg/g crt (95% CI = 0.16; 0.20), while that of DPHP standardized by crt was 2.24 µg/g crt (95% CI = 2.00; 3.52). The association of the neurodevelopment score with BDCIPP standardized by crt was -0.49 (95%CI = -1.85; 0.87; p -value = 0.48), and with DPHP standardized by crt it was -0.35 (95%CI = -1.90; 1.20; p -value = 0.66). No clear associations were observed between the neurodevelopment score and BDCIPP/DPHP concentrations that were not standardized by crt. No clear associations were observed with bis(1-chloro-2-propyl) phosphate (BCIPP) in either cohort, due to the low detection frequency of this compound. In conclusion, this study provides only limited evidence of an inverse association between neurodevelopment and exposure to BDCIPP and DPHP. The timing of exposure and effect modification of other organophosphate flame retardant metabolites and other substances should be the subject of further investigations that address this scientific hypothesis.
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- 2023
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24. Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS).
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Sarkanen T, Partinen M, Bjorvatn B, Merikanto I, Benedict C, Nadorff MR, Bolstad CJ, Espie C, Matsui K, Chung F, Morin CM, Wing YK, Penzel T, Macêdo T, Mota-Rolim S, Holzinger B, Plazzi G, De Gennaro L, Landtblom AM, Inoue Y, Sieminski M, Leger D, and Dauvilliers Y
- Subjects
- Humans, Female, Adult, Male, Pandemics, Quality of Life, Post-Acute COVID-19 Syndrome, Fatigue epidemiology, Fatigue complications, Sleep, COVID-19 epidemiology, COVID-19 complications, Disorders of Excessive Somnolence diagnosis
- Abstract
Background: The COVID-19 pandemic and related restriction measures have affected our daily life, sleep, and circadian rhythms worldwide. Their effects on hypersomnolence and fatigue remain unclear., Methods: The International COVID-19 Sleep Study questionnaire which included items on hypersomnolence such as excessive daytime sleepiness (EDS), and excessive quantity of sleep (EQS), as well as sociodemographic factors, sleep patterns, psychological symptoms, and quality of life was distributed in 15 countries across the world from May to September in 2020., Results: Altogether responses from 18,785 survey participants (65% women, median age 39 years) were available for analysis. Only 2.8% reported having had COVID-19. Compared to before the pandemic, the prevalence of EDS, EQS, and fatigue increased from 17.9% to 25.5%, 1.6%-4.9%, and 19.4%-28.3% amid the pandemic, respectively. In univariate logistic regression models, reports of having a COVID-19 were associated with EQS (OR 5.3; 95%-CI 3.6-8.0), EDS (2.6; 2.0-3.4), and fatigue (2.8; 2.1-3.6). In adjusted multivariate logistic regression, sleep duration shorter than desired (3.9; 3.2-4.7), depressive symptoms (3.1; 2.7-3.5), use of hypnotics (2.3; 1.9-2.8), and having reported COVID-19 (1.9; 1.3-2.6) remained strong predictors of EDS. Similar associations emerged for fatigue. In the multivariate model, depressive symptoms (4.1; 3.6-4.6) and reports of having COVID-19 (2.0; 1.4-2.8) remained associated with EQS., Conclusions: A large increase in EDS, EQS, and fatigue occurred due to the COVID-19 pandemic, and especially in self-reported cases of COVID-19. These findings warrant a thorough understanding of their pathophysiology to target prevention and treatment strategies for long COVID condition., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Published
- 2023
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25. ALAD and APOE polymorphisms are associated with lead and mercury levels in Italian pregnant women and their newborns with adequate nutritional status of zinc and selenium.
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Palir N, Stajnko A, Snoj Tratnik J, Mazej D, Briški AS, France-Štiglic A, Rosolen V, Mariuz M, Giordani E, Barbone F, Horvat M, and Falnoga I
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- Female, Humans, Infant, Newborn, Pregnancy, Apolipoproteins E genetics, Lead, Nutritional Status, Polymorphism, Single Nucleotide, Pregnant Women, Zinc, Mercury, Selenium, Trace Elements
- Abstract
The impacts of single-nucleotide polymorphisms (SNPs) in ALAD and VDR genes on Pb health effects and/or kinetics are inconclusive at low exposure levels, while studies including APOE SNPs are rare. In this study, we examined the associations of ALAD, VDR and APOE SNPs with exposure biomarkers of Pb and other trace elements (TEs) in Italian pregnant women (N = 873, aged 18-44 years) and their newborns (N = 619) with low-level mixed-element exposure through diet, the environment or endogenously. DNA from maternal peripheral venous blood (mB), sampled during the second and third trimesters, was genotyped for ALAD (rs1800435, rs1805313, rs1139488, rs818708), VDR (rs2228570, rs1544410, rs7975232, rs731236) and APOE (rs429358, rs7421) using TaqMan SNP assays. Personal and lifestyle data and TE levels (mB, maternal plasma, hair and mixed umbilical cord blood [CB]) from the PHIME project were used. Multiple linear regression models, controlling for confounding variables, were performed to test the associations between SNPs and TEs. The geometric means of mB-Pb, mB-Hg, mB-As and mB-Cd (11.0 ng/g, 2.16 ng/g, 1.38 ng/g and 0.31 ng/g, respectively) indicated low exposure levels, whereas maternal plasma Zn and Se (0.72 μg/mL and 78.6 ng/g, respectively) indicated adequate micronutritional status. Variant alleles of ALAD rs1800435 and rs1805313 were negatively associated with mB-Pb levels, whereas a positive association was observed for rs1139488. None of the VDR SNPs or their haplotypes had any association with Pb levels. Regarding APOE, the ϵ4 allele was associated with lower mB-Hg and CB-Hg, while a positive association was found with the ϵ2 allele and CB-Pb when the model included only newborn girls. The observed associations indicate possible modification effects of ALAD and APOE SNPs on Pb or Hg kinetics in women and their newborns with low exposure to non-essential TEs, as well as an adequate nutritional status of Zn and Se., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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26. Concurrent Assessment of Phthalates/HEXAMOLL ® DINCH Exposure and Wechsler Intelligence Scale for Children Performance in Three European Cohorts of the HBM4EU Aligned Studies.
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Rosolen V, Giordani E, Mariuz M, Parpinel M, Ronfani L, Vecchi Brumatti L, Bin M, Calamandrei G, Mustieles V, Gilles L, Govarts E, Baken K, Rodriguez Martin L, Schoeters G, Sepai O, Sovcikova E, Fabelova L, Šidlovská M, Kolena B, Kold Jensen T, Frederiksen H, Kolossa-Gehring M, Lange R, Apel P, Castano A, Esteban López M, Jacobs G, Voorspoels S, Jurdáková H, Górová R, and Barbone F
- Abstract
Information about the effects of phthalates and non-phthalate substitute cyclohexane-1,2-dicarboxylic acid diisononyl ester (HEXAMOLL
® DINCH) on children's neurodevelopment is limited. The aim of the present research is to evaluate the association between phthalate/HEXAMOLL® DINCH exposure and child neurodevelopment in three European cohorts involved in HBM4EU Aligned Studies. Participating subjects were school-aged children belonging to the Northern Adriatic cohort II (NAC-II), Italy, Odense Child Cohort (OCC), Denmark, and PCB cohort, Slovakia. In each cohort, children's neurodevelopment was assessed through the Full-Scale Intelligence Quotient score (FSIQ) of the Wechsler Intelligence Scale of Children test using three different editions. The children's urine samples, collected for one point in time concurrently with the neurodevelopmental evaluation, were analyzed for several phthalates/HEXAMOLL® DINCH biomarkers. The relation between phthalates/HEXAMOLL® DINCH and FSIQ was explored by applying separate multiple linear regressions in each cohort. The means and standard deviations of FSIQ were 109 ± 11 (NAC-II), 98 ± 12 (OCC), and 81 ± 15 (PCB cohort). In NAC-II, direct associations between FSIQ and DEHP's biomarkers were found: 5OH-MEHP+5oxo-MEHP (β = 2.56; 95% CI 0.58-4.55; N = 270), 5OH-MEHP+5cx-MEPP (β = 2.48; 95% CI 0.47-4.49; N = 270) and 5OH-MEHP (β = 2.58; 95% CI 0.65-4.51; N = 270). On the contrary, in the OCC the relation between DEHP's biomarkers and FSIQ tended to be inverse but imprecise ( p -value ≥ 0.10). No associations were found in the PCB cohort. FSIQ was not associated with HEXAMOLL® DINCH in any cohort. In conclusion, these results do not provide evidence of an association between concurrent phthalate/DINCHHEXAMOLLR DINCH exposure and IQ in children.- Published
- 2022
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27. Nutrient Intake during Pregnancy and Adherence to Dietary Recommendations: The Mediterranean PHIME Cohort.
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Concina F, Pani P, Carletti C, Rosolen V, Knowles A, Parpinel M, Ronfani L, Mariuz M, Vecchi Brumatti L, Valent F, Little D, Petrović O, Prpić I, Špirić Z, Sofianou-Katsoulis A, Mazej D, Tratnik JS, Horvat M, and Barbone F
- Subjects
- Adult, Cohort Studies, Croatia, Diet, Diet Records, Female, Greece, Humans, Italy, Pregnancy, Slovenia, Eating, Feeding Behavior, Maternal Nutritional Physiological Phenomena, Nutritional Status, Patient Compliance statistics & numerical data, Recommended Dietary Allowances
- Abstract
Few studies provide a detailed description of dietary habits during pregnancy, despite the central role of nutrition for the health of the mother and offspring. This paper describes the dietary habits, energy and nutrient intake in pregnant women from four countries belonging to the Mediterranean PHIME cohort (Croatia, Greece, Italy and Slovenia) and evaluates their adherence to the European Food Safety Authority (EFSA) recommendations. A total of 1436 women were included in the present analysis. Maternal diet was assessed using a food frequency questionnaire (FFQ). The mean macro and micronutrient intakes were estimated and compared with the dietary reference values (DRVs). The percentage distribution of the 16 food groups in the total intake of each macronutrient was estimated. All women shared a similar diet during pregnancy; almost all the women in the four countries exceeded the DRV for sugars, and the total fat intake was above the DRV in most women in all the countries, as was the contribution of saturated fatty acids (SFAs) to the total energy intake. In all four countries, we observed an increased risk of micronutrient deficiency for iron, folate and vitamin D. Shared guidelines, implemented at both the national and European level, are essential to improve the maternal nutritional status during pregnancy.
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- 2021
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28. Impact of Methylmercury and Other Heavy Metals Exposure on Neurocognitive Function in Children Aged 7 Years: Study Protocol of the Follow-up.
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Vecchi Brumatti L, Rosolen V, Mariuz M, Piscianz E, Valencic E, Bin M, Athanasakis E, D'Adamo P, Fragkiadoulaki E, Calamandrei G, Dinckol Ö, Barbone F, and Ronfani L
- Subjects
- Adult, Animals, Child, Child, Preschool, Diet Surveys, Female, Fishes, Follow-Up Studies, Food Contamination, Hair chemistry, Humans, Infant, Italy epidemiology, Male, Metals, Heavy analysis, Metals, Heavy urine, Methylmercury Compounds analysis, Methylmercury Compounds urine, Pregnancy, Prospective Studies, Maternal Nutritional Physiological Phenomena, Metals, Heavy toxicity, Methylmercury Compounds toxicity, Neurodevelopmental Disorders epidemiology, Prenatal Exposure Delayed Effects
- Abstract
Background: The extent to which prenatal low-level mercury (Hg) exposure through maternal fish intake and heavy metals exposure affect children's neurodevelopment is controversial and may appear in the long term. In 2007, a prospective cohort, the Northern Adriatic Cohort II (NAC-II), was established to investigate the association between prenatal Hg exposure from maternal fish consumption and child neurodevelopment. The study enrolled 900 pregnant women, and 632 and 470 children underwent neurodevelopmental evaluation at 18 and 40 months of age, respectively. The NAC-II cohort is a part of the Mediterranean cohort in the "Public health impact of long-term, low-level, mixed element exposure in susceptible population strata" project., Methods: This protocol describes the follow-up assessment of the effects of prenatal low level Hg and other heavy metals exposure on the developing nervous system of the children born within the NAC-II who reached the age of 7 years. Child diet components are estimated through a Diet Diary. Child hair and urine are collected for determination of Hg level. In addition, levels of other potentially neurotoxic metals, namely Manganese, Cadmium, Lead, Arsenic, and Selenium, are also measured in the same matrices., Discussion: This protocol extends to the first years of schooling age the evaluation of the neurotoxicant effect of Mercury and of the other heavy metals on children's neurodevelopment, adjusting for the potential confounders, such as the lifestyles and social economic status of children's families. Longitudinal analysis of neurodevelopment, assessed in different ages (18 months, 40 months, and 7 years), are performed.
- Published
- 2021
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29. The role of mercury, selenium and the Se-Hg antagonism on cognitive neurodevelopment: A 40-month follow-up of the Italian mother-child PHIME cohort.
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Castriotta L, Rosolen V, Biggeri A, Ronfani L, Catelan D, Mariuz M, Bin M, Brumatti LV, Horvat M, and Barbone F
- Subjects
- Adult, Animals, Child, Preschool, Cognition, Female, Fishes, Follow-Up Studies, Humans, Mother-Child Relations, Pregnancy, Prospective Studies, Mercury, Selenium
- Abstract
Despite a 15-year long effort to define the "safety" of fish intake during pregnancy, there remains still uncertainty on this important public health issue. The evaluation of the toxic effects of contaminants, particularly mercury (Hg) in fish-eating populations is complicated by the fact that sea-food is also rich in beneficial nutrients, such as selenium (Se). There is toxicological plausibility of an antagonistic effects between Se and Hg, and some theoretical support for the inclusion of the Se-Hg interaction to better assess the risk linked with fish intake. To assess the effects of exposure to low-level Hg through fish consumption on the developing brain and the interaction between Hg and Se, we conducted an analysis at age 40 months in Italian children, enrolled in a prospective mother-child cohort, comparing additive and multiplicative models. Participant subjects were the 470 children born within the Northern Adriatic Cohort II (NAC-II) cohort who were tested by using the Bayley Scales of Infant and Toddler Development third edition (Bayley-III) (BSID-III) at age 40. Family demographic and socioeconomic information, pregnancy and delivery history, parental and child medical history and food consumption were assessed through questionnaires. Maternal blood samples were collected during pregnancy, cord blood at birth and maternal milk 1 month after delivery. As other exposures of interest, we considered the level of Se in maternal and cord blood and in breast milk and the potential Se-Hg antagonism. Se and inverse of THg (1:THg) concentrations were categorized according to the tertiles of their distributions, in low, medium and high levels of exposure. The lower end of the composite cognitive score distribution closest to 20% was defined as suboptimal development. Multiple logistic regression were applied to assess the association between the dichotomized composite cognitive score and the categorized exposure to Se and 1:THg, and the antagonism between Se and 1:THg. In the recruiting period, 900 pregnant women were enrolled in the cohort; 767 of these remained in the study at delivery and 470 children at 40 months. After excluding preterm births, 456 children were used in the final analyses. The larger difference in risk for suboptimal neurodevelopment was observed for the category with High THg and Low Se with OR = 2.55 (90% CI 1.02; 6.41) under the multiplicative and OR = 1.33 (90% CI 0.80; 1.87) under the additive model. The category High THg and High Se showed a very slightly better fit of the additive model (OR = 1.07, 90% CI 0.65; 1.50) versus the multiplicative (OR = 1.66, 90% CI 0.73; 1.77). A negative - antagonistic - interaction term for this category was estimated under the multiplicative model giving an OR = 1.17 (90% CI 0.42; 3.28). Although this evidence of the effects of the Se-Hg antagonism on the children neuro-development needs to be confirmed, if Se can counterbalance Hg toxicity, the evaluation of the effect on human health of fish consumption, should also consider the diverse ratios between Se and Hg concentration in different fish species., (Copyright © 2020 The Authors. Published by Elsevier GmbH.. All rights reserved.)
- Published
- 2020
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30. Prenatal mercury exposure and child neurodevelopment outcomes at 18 months: Results from the Mediterranean PHIME cohort.
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Barbone F, Rosolen V, Mariuz M, Parpinel M, Casetta A, Sammartano F, Ronfani L, Vecchi Brumatti L, Bin M, Castriotta L, Valent F, Little DL, Mazej D, Snoj Tratnik J, Miklavčič Višnjevec A, Sofianou K, Špirić Z, Krsnik M, Osredkar J, Neubauer D, Kodrič J, Stropnik S, Prpić I, Petrović O, Vlašić-Cicvarić I, and Horvat M
- Subjects
- Adult, Environmental Exposure adverse effects, Female, Humans, Infant, Mercury blood, Pregnancy, Young Adult, Child Development drug effects, Mercury toxicity, Neurodevelopmental Disorders chemically induced, Prenatal Exposure Delayed Effects
- Abstract
Introduction: Neurotoxicity due to acute prenatal exposure to high-dose of mercury (Hg) is well documented. However, the effect of prenatal exposure to low Hg levels on child neurodevelopment and the question about "safety" of fish-eating during pregnancy remain controversial. International comparisons of Hg concentrations in mother-child biological samples and neurodevelopmental scores embedded in birth cohort studies may provide useful evidence to explore this issue., Materials and Methods: The Mediterranean (Italy, Slovenia, Croatia, and Greece) cohort study included 1308 mother-child pairs enrolled in the Public Health Impact of long-term, low-level, Mixed Element exposure in a susceptible population EU Sixth Framework Programme (PHIME). Maternal hair and venous blood, cord blood and breast milk samples were collected, and total Hg (THg) levels were measured. Demographic and socioeconomic information, lifestyles and nutritional habits were collected through questionnaires at different phases of follow-up. Children at 18 months of age underwent neurodevelopmental testing using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Multivariate linear and logistic regressions were performed, for each country, to assess the association between THg and BSID-III scores, obtaining adjusted β coefficients and odds ratios (ORs). These values were used to conduct a meta-analysis, to explore possible heterogeneity among countries and to obtain combined estimates of the association between THg exposure and BSID-III scores., Results: Median THg (ng/g) was: 704 in maternal hair, 2.4 in maternal blood, 3.6 in cord blood, and 0.6 in breast milk. THg concentrations were highest in Greece and lowest in Slovenia. BSID-III neurodevelopmental scores were higher in Croatia and Slovenia. The meta-analysis of multivariate linear models found an overall positive association between language composite score and receptive communication scaled score and increasing THg in maternal hair (n = 1086; β = 0.55; 95%CI: 0.05-1.05 and n = 1075; β = 0.12; 95%CI: 0.02-0.22, respectively). The meta-analysis of logistic regression models showed that the overall adjusted OR between THg in cord blood and suboptimal gross motor score was borderline significant (n = 882; OR = 1.03; 95%CI: 1.00-1.07). Heterogeneity was found across the four sub-cohorts for language composite score in maternal blood, and for fine motor scaled score in cord blood and breast milk. Language composite score and THg concentrations in maternal venous blood were positively related (n = 58; β = 4.29; CI95% (-0.02, 8.60)) in Croatia and an increase of 1 ng/g of THg in maternal venous blood was associated with a reduced risk for children to fall in the lowest quintile of language score by 31% (n = 58; OR = 0.69; CI 95%: 0.37, 1.01). The comparison of β coefficients obtained by multiple linear regression model showed an inverse association between fine motor score and THg concentrations in cord blood for Croatia (n = 54; β = -0.53; CI 95%: -1.10, 0.04) and Slovenia (n = 225; β = -0.25; CI 95%: -0.49, -0.01). In Slovenia THg level in breast milk was associated with suboptimal fine motor performance (n = 195; OR = 5.25; CI 95%: 1.36, 21.10)., Conclusions: This study showed an inverse relation between THg levels and developmental motor scores at 18 months, although the evidence was weak and partially internally and externally inconsistent. No evidence of detrimental effects of THg was found for cognitive and language outcomes at these concentrations and age., (Copyright © 2018 Elsevier GmbH. All rights reserved.)
- Published
- 2019
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31. CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment.
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Llop S, Tran V, Ballester F, Barbone F, Sofianou-Katsoulis A, Sunyer J, Engström K, Alhamdow A, Love TM, Watson GE, Bustamante M, Murcia M, Iñiguez C, Shamlaye CF, Rosolen V, Mariuz M, Horvat M, Tratnik JS, Mazej D, van Wijngaarden E, Davidson PW, Myers GJ, Rand MD, and Broberg K
- Subjects
- Adult, Child, Preschool, Cohort Studies, Female, Fetal Blood chemistry, Genotype, Greece, Humans, Infant, Italy, Male, Mercury blood, Neurodevelopmental Disorders chemically induced, Neurodevelopmental Disorders genetics, Neuropsychological Tests, Polymorphism, Genetic, Pregnancy, Seychelles, Spain, Child Development drug effects, Cytochrome P-450 CYP3A genetics, Methylmercury Compounds toxicity, Prenatal Exposure Delayed Effects genetics
- Abstract
Background: Results on the association between prenatal exposure to methylmercury (MeHg) and child neuropsychological development are heterogeneous. Underlying genetic differences across study populations could contribute to this varied response to MeHg. Studies in Drosophila have identified the cytochrome p450 3A (CYP3A) family as candidate MeHg susceptibility genes., Objectives: We evaluated whether genetic variation in CYP3A genes influences the association between prenatal exposure to MeHg and child neuropsychological development., Methods: The study population included 2639 children from three birth cohort studies: two subcohorts in Seychelles (SCDS) (n=1160, 20 and 30months of age, studied during the years 2001-2012), two subcohorts from Spain (INMA) (n=625, 14months of age, 2003-2009), and two subcohorts from Italy and Greece (PHIME) (n=854, 18months of age, 2006-2011). Total mercury, as a surrogate of MeHg, was analyzed in maternal hair and/or cord blood samples. Neuropsychological development was evaluated using Bayley Scales of Infant Development (BSID). Three functional polymorphisms in the CYP3A family were analyzed: rs2257401 (CYP3A7), rs776746 (CYP3A5), and rs2740574 (CYP3A4)., Results: There was no association between CYP3A polymorphisms and cord mercury concentrations. The scores for the BSID mental scale improved with increasing cord blood mercury concentrations for carriers of the most active alleles (β[95% CI]:=2.9[1.53,4.27] for CYP3A7 rs2257401 GG+GC, 2.51[1.04,3.98] for CYP3A5 rs776746 AA+AG and 2.31[0.12,4.50] for CYP3A4 rs2740574 GG+AG). This association was near the null for CYP3A7 CC, CYP3A5 GG and CYP3A4 AA genotypes. The interaction between the CYP3A genes and total mercury was significant (p<0.05) in European cohorts only., Conclusions: Our results suggest that the polymorphisms in CYP3A genes may modify the response to dietary MeHg exposure during early life development., (Copyright © 2017. Published by Elsevier Ltd.)
- Published
- 2017
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32. A case-crossover study of sleep, fatigue, and other transient exposures at workplace and the risk of non-fatal occupational injuries among the employees of an Italian academic hospital.
- Author
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Valent F, Mariuz M, Liva G, Bellomo F, De Corti D, Degan S, Ferrazzano A, and Brusaferro S
- Subjects
- Adult, Cross-Over Studies, Female, Hospitals, Humans, Italy epidemiology, Male, Middle Aged, Occupational Exposure adverse effects, Occupational Injuries etiology, Accidents, Occupational statistics & numerical data, Fatigue, Occupational Injuries epidemiology, Personnel, Hospital statistics & numerical data, Risk Factors, Sleep Deprivation complications
- Abstract
Objectives: Transient exposure with acute effect has been shown to affect the risk of occupational injuries in various industrial settings and at the healthcare workplace. The objective of this study has been to identify transient exposures related to occupational injury risk in an Italian teaching hospital., Material and Methods: A case-crossover study was conducted among the employees of the University Hospital of Udine who reported an occupational injury, commuting accident, or incident involving biological risk in a 15-month period in the years 2013 and 2014. The matched-pair interval approach was used to assess the role of acute sleep deprivation whereas the usual frequency approach was used for other 13 transient exposures., Results: Sleep hours were not associated with the risk of injuries whereas a significant risk increase was associated with fatigue, rush, distraction, emergency situations, teaching to or being taught by someone, non-compliant patients, bloody operative/work field, excess noise, complex procedures, and anger., Conclusions: We identified transient exposures that increased the risk of occupational injuries in an Italian teaching hospital, providing indications for interventions to increase workers' safety at the healthcare workplace. Int J Occup Med Environ Health 2016;29(6):1001-1009., (This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.)
- Published
- 2016
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33. Salivary melatonin and cortisol and occupational injuries among Italian hospital workers.
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Valent F, Mariuz M, Liva G, Verri S, Arlandini S, and Vivoli R
- Subjects
- Adult, Aged, Case-Control Studies, Circadian Rhythm physiology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hydrocortisone metabolism, Italy, Male, Middle Aged, Occupational Injuries psychology, Time Factors, Young Adult, Melatonin metabolism, Occupational Injuries metabolism, Personnel, Hospital, Saliva chemistry
- Abstract
Stress, circadian patterns, and sleep-related factors may have a role on occupational injuries. We investigated the association between occupational injuries among the workers of an Italian hospital and their secretion of salivary melatonin and cortisol. We used a case-control study design. 27 injured cases and 31 non-injured controls provided 5 salivary samples every 60 min from 9 pm to 1 am. Melatonin and cortisol concentrations were measured, and the Dim Light Melatonin Onset (DLMO) derived using two fixed thresholds (1 and 3 pg/mL). The associations between injury, melatonin, cortisol, and DLMO were assessed through univariate and multivariate analyses. Non-injured controls had higher melatonin (median 2.28 pg/mL) and lower cortisol concentrations (0.71 ng/mL), as well as earlier DLMO times (9:00 pm with the 1 pg/mL melatonin cutoff) than cases (1.01 pg/mL, 1.14 ng/mL and 9:12 pm, respectively), although only few results were statistically significant. Measuring these hormones might be helpful to characterize the risk of injury among hospital workers.
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- 2016
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34. The Complex Interaction between Home Environment, Socioeconomic Status, Maternal IQ and Early Child Neurocognitive Development: A Multivariate Analysis of Data Collected in a Newborn Cohort Study.
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Ronfani L, Vecchi Brumatti L, Mariuz M, Tognin V, Bin M, Ferluga V, Knowles A, Montico M, and Barbone F
- Subjects
- Adult, Female, Humans, Infant, Italy, Language Development, Male, Motor Activity, Multivariate Analysis, Prospective Studies, Public Health Surveillance, Socioeconomic Factors, Child Development, Cognition, Family, Intelligence, Mother-Child Relations, Social Class
- Abstract
Background: The relative role of socioeconomic status (SES), home environment and maternal intelligence, as factors affecting child cognitive development in early childhood is still unclear. The aim of this study is to analyze the association of SES, home environment and maternal IQ with child neurodevelopment at 18 months., Methods: The data were collected prospectively in the PHIME study, a newborn cohort study carried out in Italy between 2007 and 2010. Maternal nonverbal abilities (IQ) were evaluated using the Standard Progressive Matrices, a version of the Raven's Progressive Matrices; a direct evaluation of the home environment was carried out with the AIRE instrument, designed using the HOME (Home Observation for Measurement of the Environment) model; the socioeconomic characteristics were evaluated using the SES index which takes into account parents occupation, type of employment, educational level, homeownership. The study outcome was child neurodevelopment evaluated at 18 months, with the Bayley Scales of Infant and Toddler Development Third Edition (BSID III). Linear regression analyses and mediation analyses were carried out to evaluate the association between the three exposures, and the scaled scores of the three main scales of BSID III (cognitive, language and motor scale), with adjustment for a wide range of potential explanatory variables., Results: Data from 502 mother-child pairs were analyzed. Mediation analysis showed a relationship between SES and maternal IQ, with a complete mediation effect of home environment in affecting cognitive and language domains. A direct significant effect of maternal IQ on the BSID III motor development scale and the mediation effect of home environment were found., Conclusions: Our results show that home environment was the variable with greater influence on neurodevelopment at 18 months. The observation of how parents and children interact in the home context is crucial to adequately evaluate early child development.
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- 2015
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35. Associations of prenatal mercury exposure from maternal fish consumption and polyunsaturated fatty acids with child neurodevelopment: a prospective cohort study in Italy.
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Valent F, Mariuz M, Bin M, Little D, Mazej D, Tognin V, Tratnik J, McAfee AJ, Mulhern MS, Parpinel M, Carrozzi M, Horvat M, Tamburlini G, and Barbone F
- Subjects
- Adult, Animals, Diet Surveys, Fatty Acids, Unsaturated blood, Female, Humans, Infant, Italy, Male, Mercury analysis, Nervous System growth & development, Pregnancy, Prospective Studies, Child Development drug effects, Fishes, Food Contamination, Maternal Nutritional Physiological Phenomena, Mercury toxicity, Nervous System drug effects, Prenatal Exposure Delayed Effects
- Abstract
Background: Mercury is a neurotoxin, and limited prenatal exposure to it can affect long-term child neurodevelopment. However, results of epidemiologic studies of such exposure have been inconsistent. We examined the association of prenatal mercury exposure from maternal fish consumption with child neurodevelopment in northern Italy., Methods: A population-based cohort of 606 children and their mothers was studied from pregnancy to age 18 months. Mercury levels were measured in maternal hair and blood during pregnancy and in umbilical cord blood and breast milk. Levels of polyunsaturated fatty acids (PUFAs) were measured in maternal serum. Maternal and child intakes of fish were assessed by using a food frequency questionnaire. The Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) was used to evaluate child neurodevelopment. Multivariate linear regression was used to examine the association of mercury exposure with BSID-III scores, after controlling for maternal fish intake, PUFAs during pregnancy, and several other confounders., Results: Mean weekly fish intake during pregnancy was less than 2 servings. Mercury concentrations in biological samples were low (mean, 1061 ng/g in hair) and moderately correlated with fish intake, particularly of carnivorous species. Maternal ω-3 PUFA concentrations were poorly correlated with fish intake. Maternal intelligence quotient (IQ) and child intake of fish were significantly associated with neurodevelopment scores. In multivariate models, the level of Hg exposure was not associated with neurodevelopmental performance at 18 months., Conclusions: In this Italian population, neurodevelopment at 18 months was associated with child intake of fresh fish and maternal IQ rather than with mercury exposure. The expected beneficial effect of maternal fish intake (from maternal ω-3 PUFAs) was not found.
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- 2013
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36. [Environmental indicators in EpiAir2 project: air quality data for epidemiological surveillance].
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Gandini M, Berti G, Cattani G, Faustini A, Scarinzi C, De'donato F, Accetta G, Angiuli L, Caldara S, Carreras G, Casale P, Di Biagio K, Giannini S, Iuzzolino C, Lanzani G, Lauriola P, Leuci P, Mariuz M, Marchesi S, Nocioni A, Pistollato S, Pizzi L, Ranzi A, Serinelli M, Stagaro E, Vianello L, Vigotti MA, Zauli-Sajani S, Cadum E, and Faustini A
- Subjects
- Air Pollutants analysis, Humans, Italy, Nitrogen Dioxide analysis, Ozone analysis, Particulate Matter analysis, Urban Health, Air Pollution analysis, Environmental Monitoring, Epidemiological Monitoring
- Abstract
Objective: construction of environmental indicators of air pollution suitable for epidemiological surveillance in 25 Italian cities for EpiAir2 project (2006-2010) and presentation of the results from a 10 years of surveillance system (2001-2010) in 10 Italian cities., Design: data on particulate matter (PM10 and its fine fraction PM2.5), nitrogen dioxide (NO2), and ozone (O3), measured in the 2006-2010 calendar period, were collected. Meteorological data needed to estimate unbiased measures of the effect of pollutants are: temperature, relative humidity (estimated "apparent temperature"), and barometric pressure. In continuity with the previous EpiAir project, the same criteria for the selection of monitoring stations were applied and standard methods to estimate daily environmental indicators were used. Furthermore, it was checked the adequacy of the selected data to represent the population exposure., Setting and Participants: EpiAir2 project, relative to the period 2006-2010, involves the cities of Milano, Mestre-Venezia, Torino, Bologna, Firenze, Pisa, Roma, Taranto, Cagliari, and Palermo, already included in the previous study. The city of Treviso, Trieste, Padova, Rovigo, Piacenza, Parma, Ferrara, Reggio Emilia, Modena, Genova, Rimini, Ancona, Bari, Brindisi, and Napoli are added to the previous group., Results: particulate matter concentrations have decreased in most cities during the study period, while concentrations of NO2 and ozone do not show a similar clear trend. The analysis of the trend showed annual mean values of PM10 higher than 40 µg/m(3) in some areas of the Po Valley, and annual mean values of NO2 higher than 40 µg/m(3) in the cities of Trieste, Milano, Padova, Torino, Modena, Bologna, Roma, and Napoli., Conclusion: the enlargement of the EpiAir project to 13 other cities has highlighted critical issues related to the different geographical areas under study. Results of EpiAir2 project point out the need of a monitoring system of air pollution concentrations in both urban and industrial sites, in order to obtain reliable estimates of exposure for resident populations and to evaluate the related time trend.
- Published
- 2013
37. Neurodevelopmental effects of low-level prenatal mercury exposure from maternal fish consumption in a Mediterranean cohort: study rationale and design.
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Valent F, Horvat M, Sofianou-Katsoulis A, Spiric Z, Mazej D, Little D, Prasouli A, Mariuz M, Tamburlini G, Nakou S, and Barbone F
- Subjects
- Animals, Child Development drug effects, Female, Follow-Up Studies, Humans, Infant, Maternal Exposure statistics & numerical data, Mediterranean Region epidemiology, Nervous System drug effects, Nervous System growth & development, Pregnancy, Prospective Studies, Research Design, Fishes, Food Contamination, Maternal Exposure adverse effects, Mercury Poisoning, Nervous System epidemiology, Prenatal Exposure Delayed Effects epidemiology
- Abstract
Background: Mercury is a neurotoxic environmental pollutant. However, the literature on the neurodevelopmental effect of low-level prenatal mercury exposure from maternal fish intake is inconsistent. We assessed the association between prenatal mercury exposure and infant neurodevelopment in coastal areas of 4 Mediterranean countries., Methods: This was a prospective cohort study that planned to enroll approximately 1700 mother-infant pairs. Pregnant women and their newborn children were recruited in selected hospitals of the study areas. Biological samples, including maternal hair and cord blood, were collected from mothers and children, and the concentrations of mercury and other elements were measured. Exposures to lifestyle, environmental, and social factors were assessed through questionnaires. The main outcome was child neurodevelopment at 18 months, as measured by the Bayley Scales of Infant and Toddler Development, Third Edition., Conclusions: This cohort has a number of strengths. First, mercury concentration was measured in several biological samples, which allows for a better understanding of mercury kinetics and is useful for sensitivity analyses. Therefore, we expect to be able to adjust for the potential confounding effects of lifestyle and social factors and for the effects of other elements that were measured in the biological samples. Finally, this is a multinational study and thus permits assessment of the relation between mercury and child neurodevelopment in different populations.
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- 2013
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38. Mercury, arsenic and selenium exposure levels in relation to fish consumption in the Mediterranean area.
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Miklavčič A, Casetta A, Snoj Tratnik J, Mazej D, Krsnik M, Mariuz M, Sofianou K, Spirić Z, Barbone F, and Horvat M
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- Adolescent, Adult, Animals, Arsenic urine, Biomarkers analysis, Female, Fetal Blood chemistry, Fishes, Hair chemistry, Humans, Mediterranean Region, Milk, Human chemistry, Pregnancy, Prospective Studies, Selenium urine, Young Adult, Arsenic blood, Maternal Exposure statistics & numerical data, Mercury blood, Seafood statistics & numerical data, Selenium blood
- Abstract
In order to assess mercury (Hg), selenium (Se) and arsenic (As) exposure in the Mediterranean area, total mercury (THg), monomethylmercury (MeHg), Se and As levels were measured in umbilical cord blood and breast milk from Italian (n=900), Slovenian (n=584), Croatian (n=234) and Greek (n=484) women. THg, MeHg, As, and Se levels were also determined in blood samples of the same mothers from Italy and Croatia. In addition, THg and MeHg were determined in the same women's hair from all the countries involved in this study and As and Se levels were determined in the mother's urine samples from Italy, Croatia and Greece. Besides recording the consumption of other food items, the frequencies of fish consumption were assessed by detailed food frequency questionnaires, since fish represents an important source of Hg, Se and As in humans. The highest levels of THg and As were found in cord blood (Med((THg))=5.8 ng/g; Med((As))=3.3 ng/g) and breast milk (Med((THg))=0.6 ng/g; Med((As))=0.8 ng/g) from Greek women, while the highest Se levels were found in cord blood (Med=113 ng/g) from Italy. Significant linear correlations were found between Hg, Se and As in blood, cord blood and breast milk. In addition, significant relations were found between the frequencies of total fish consumption and biomarkers of As, MeHg and Se exposure, with the strongest Spearman rank coefficients between frequencies of total fish consumption and THg levels in cord blood (r(s)=0.442, p<0.001) or THg levels in hair (r(s)=0.421, p<0.001), and between frequencies of total fish consumption and As levels in cord blood (r(s)=0.350, p<0.001). The differences in Hg and As exposure between countries were probably due to different amounts of fish consumption and the consumption of different species of fish of different origin, while the highest Se levels in women from Italy were probably the consequence of the more frequent consumption of different non specific food items. Moreover, fish consumption, the possible common source of As, Hg and Se intake, could explain the correlations between the elements determined in cord blood, mother's blood or breast milk., (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Published
- 2013
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39. [Fetal and perinatal exposure to mercury and selenium: baseline evaluation of a cohort of children in Friuli Venezia Giulia, Italy].
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Valent F, Pisa F, Mariuz M, Horvat M, Gibicar D, Fajon V, Mazej D, Daris F, and Barbone F
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- Adult, Animals, Dental Amalgam adverse effects, Dental Amalgam analysis, Female, Fishes, Follow-Up Studies, Food Contamination, Hair chemistry, Humans, Infant, Newborn, Italy epidemiology, Learning Disabilities chemically induced, Learning Disabilities epidemiology, Maternal Exposure, Maternal-Fetal Exchange, Mercury pharmacokinetics, Methylmercury Compounds adverse effects, Methylmercury Compounds pharmacokinetics, Milk, Human chemistry, Nervous System drug effects, Nervous System embryology, Neurotoxins pharmacokinetics, Pregnancy, Prenatal Exposure Delayed Effects chemically induced, Prospective Studies, Seafood adverse effects, Seafood analysis, Selenium pharmacokinetics, Socioeconomic Factors, Fetus drug effects, Mercury adverse effects, Neurotoxins adverse effects, Prenatal Exposure Delayed Effects epidemiology, Selenium adverse effects
- Abstract
Objective: neurotoxicity of prenatal exposure to high concentrations of mercury (Hg) is well known; however, the doseresponse relationship at low exposure levels has not been quantified yet. This article illustrates the measurement of prenatal exposure to Hg and the pathway of exposure through the diet in Friuli Venezia Giulia, Italy., Design: description of a prospective cohort at the baseline., Setting and Participants: 242 mother- infant pairs living in Friuli Venezia Giulia were enrolled between 1999 and 2001., Main Outcome Measures: We measured the concentrations of Hg in the hair of mothers and children and of Hg and selenium (Se) in breast milk. The diet during pregnancy was estimated through a food frequency questionnaire (FFQ) with a detailed section regarding fish. We calculated the correlations between Hg and Se in the biological samples and estimated the association between Hg concentrations and fish consumption., Results: in general, Hg levels in hair and milk were positively associated with the consumption of fish from the lagoon of Grado and Marano. However, they were low in comparison with those of other fish-eating populations and below theWHO alert limits, likely because of the small consumption of fish among pregnant women, estimated from the FFQ. The concentration of Se in milk was also smaller than that reported in other international studies., Conclusion: in Friuli Venezia Giulia, fetal and perinatal Hg exposure is low. The children of the cohort will be followed- up at school age to measure possible neurodevelopmental effects of such low exposures to Hg.
- Published
- 2011
40. ENURESIS IN NON-PSYCHOTIC BOYS TREATED WITH IMIPRAMINE.
- Author
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MARIUZ MJ and WALTERS CJ
- Subjects
- Child, Humans, Male, Enuresis, Imipramine
- Published
- 1963
- Full Text
- View/download PDF
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