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23 results on '"Maritan, Sarah M"'

2. Single-cell spatial immune landscapes of primary and metastatic brain tumours

Author

Karimi, Elham, Yu, Miranda W., Maritan, Sarah M., Perus, Lucas J. M., Rezanejad, Morteza, Sorin, Mark, Dankner, Matthew, Fallah, Parvaneh, Doré, Samuel, Zuo, Dongmei, Fiset, Benoit, Kloosterman, Daan J., Ramsay, LeeAnn, Wei, Yuhong, Lam, Stephanie, Alsajjan, Roa, Watson, Ian R., Roldan Urgoiti, Gloria, Park, Morag, Brandsma, Dieta, Senger, Donna L., Chan, Jennifer A., Akkari, Leila, Petrecca, Kevin, Guiot, Marie-Christine, Siegel, Peter M., Quail, Daniela F., and Walsh, Logan A.

Published
2023
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3. Single-cell spatial landscapes of the lung tumour immune microenvironment

Author

Sorin, Mark, Rezanejad, Morteza, Karimi, Elham, Fiset, Benoit, Desharnais, Lysanne, Perus, Lucas J. M., Milette, Simon, Yu, Miranda W., Maritan, Sarah M., Doré, Samuel, Pichette, Émilie, Enlow, William, Gagné, Andréanne, Wei, Yuhong, Orain, Michele, Manem, Venkata S. K., Rayes, Roni, Siegel, Peter M., Camilleri-Broët, Sophie, Fiset, Pierre Olivier, Desmeules, Patrice, Spicer, Jonathan D., Quail, Daniela F., Joubert, Philippe, and Walsh, Logan A.

Published
2023
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7. Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes.

Author

Dankner, Matthew, Maritan, Sarah M, Priego, Neibla, Kruck, Georgia, Nkili-Meyong, Andriniaina, Nadaf, Javad, Zhuang, Rebecca, Annis, Matthew G, Zuo, Dongmei, Nowakowski, Alexander, Biondini, Marco, Kiepas, Alexander, Mourcos, Caitlyn, Le, Phuong, Charron, François, Inglebert, Yanis, Savage, Paul, Théret, Louis, Guiot, Marie-Christine, and McKinney, R Anne

Published
2024
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8. Intrathecal trastuzumab versus alternate routes of delivery for HER2-targeted therapies in patients with HER2+ breast cancer leptomeningeal metastases

Author

Lazaratos, Anna-Maria, primary, Maritan, Sarah M., additional, Quaiattini, Andrea, additional, Darlix, Amelie, additional, Ratosa, Ivica, additional, Ferraro, Emanuela, additional, Griguolo, Gaia, additional, Guarneri, Valentina, additional, Pellerino, Alessia, additional, Hofer, Silvia, additional, Jacot, William, additional, Stemmler, Hans-Joachim, additional, van den Broek, Marcel P.H., additional, Dobnikar, Nika, additional, Panet, Francois, additional, Lahijanian, Zubin, additional, Morikawa, Aki, additional, Seidman, Andrew D., additional, Soffietti, Riccardo, additional, Panasci, Lawrence, additional, Petrecca, Kevin, additional, Rose, April A.N., additional, Bouganim, Nathaniel, additional, and Dankner, Matthew, additional

Published
2023
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9. Abstract 69: Minimally invasive brain metastases are characterized by elevated immune cell infiltrate

Author

Maritan, Sarah M., primary, Karimi, Elham, additional, Dankner, Matthew, additional, Yu, Miranda W., additional, Hernandez-Corchado, Aldo, additional, Rezanejad, Morteza, additional, Fallah, Parvaneh, additional, Fiset, Benoit, additional, Wei, Yuhong, additional, Lam, Stephanie, additional, Nehme, Ali, additional, Watson, Ian R., additional, Park, Morag, additional, Riazalhosseini, Yasser, additional, Najafabadi, Hamed, additional, Petrecca, Kevin, additional, Guiot, Marie-Christine, additional, Quail, Daniela F., additional, Walsh, Logan A., additional, and Siegel, Peter M., additional

Published
2023
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11. Intrathecal trastuzumab versus alternate routes of delivery for HER2-targeted therapies in patients with HER2+ breast cancer leptomeningeal metastases

Author

Lazaratos, Anna-Maria, Maritan, Sarah M, Quaiattini, Andrea, Darlix, Amélie, Ratosa, Ivica, Ferraro, Emanuela, Griguolo, Gaia, Guarneri, Valentina, Pellerino, Alessia; https://orcid.org/0000-0003-3243-0059, Hofer, Silvia; https://orcid.org/0000-0002-0831-2098, Jacot, William, Stemmler, Hans-Joachim, van den Broek, Marcel P H, Dobnikar, Nika, Panet, Francois, Lahijanian, Zubin, Morikawa, Aki, Seidman, Andrew D, Soffietti, Riccardo; https://orcid.org/0000-0002-9204-7038, Panasci, Lawrence, Petrecca, Kevin, Rose, April A N, Bouganim, Nathaniel, Dankner, Matthew; https://orcid.org/0000-0003-4869-5895, Lazaratos, Anna-Maria, Maritan, Sarah M, Quaiattini, Andrea, Darlix, Amélie, Ratosa, Ivica, Ferraro, Emanuela, Griguolo, Gaia, Guarneri, Valentina, Pellerino, Alessia; https://orcid.org/0000-0003-3243-0059, Hofer, Silvia; https://orcid.org/0000-0002-0831-2098, Jacot, William, Stemmler, Hans-Joachim, van den Broek, Marcel P H, Dobnikar, Nika, Panet, Francois, Lahijanian, Zubin, Morikawa, Aki, Seidman, Andrew D, Soffietti, Riccardo; https://orcid.org/0000-0002-9204-7038, Panasci, Lawrence, Petrecca, Kevin, Rose, April A N, Bouganim, Nathaniel, and Dankner, Matthew; https://orcid.org/0000-0003-4869-5895

Abstract

Background: Patients with HER2+ breast cancer (BC) frequently develop leptomeningeal metastases (LM). While HER2-targeted therapies have demonstrated efficacy in the neoadjuvant, adjuvant, and metastatic settings, including for parenchymal brain metastases, their efficacy for patients with LM has not been studied in a randomized controlled trial. However, several single-armed prospective studies, case series and case reports have studied oral, intravenous, or intrathecally administered HER2-targeted therapy regimens for patients with HER2+ BC LM. Methods: We conducted a systematic review and meta-analysis of individual patient data to evaluate the efficacy of HER2-targeted therapies in HER2+ BC LM in accordance with PRISMA guidelines. Targeted therapies evaluated were trastuzumab (intrathecal or intravenous), pertuzumab, lapatinib, neratinib, tucatinib, trastuzumab-emtansine and trastuzumab-deruxtecan. The primary endpoint was overall survival (OS), with CNS-specific progression-free survival (PFS) as a secondary endpoint. Results: 7780 abstracts were screened, identifying 45 publications with 208 patients, corresponding to 275 lines of HER2-targeted therapy for BC LM which met inclusion criteria. In univariable and multivariable analyses, we observed no significant difference in OS and CNS-specific PFS between intrathecal trastuzumab compared to oral or intravenous administration of HER2-targeted therapy. Anti-HER2 monoclonal antibody-based regimens did not demonstrate superiority over HER2 tyrosine kinase inhibitors. In a cohort of 15 patients, treatment with trastuzumab-deruxtecan was associated with prolonged OS compared to other HER2-targeted therapies and compared to trastuzumab-emtansine. Conclusions: The results of this meta-analysis, comprising the limited data available, suggest that intrathecal administration of HER2-targeted therapy for patients with HER2+ BC LM confers no additional benefit over oral and/or IV treatment regimens. Although the number of

Published
2023

12. Abstract 1569: pSTAT3+ stromal cells drive the invasive growth of brain metastases

Author

Dankner, Matthew, primary, Maritan, Sarah M., additional, Priego, Neibla, additional, Nadaf, Javad, additional, Nkili, Andy, additional, Zhuang, Rebecca, additional, Kruck, Georgia, additional, Zuo, Dongmei, additional, Nowakowski, Alexander, additional, Inglebert, Yanis, additional, Savage, Paul, additional, Park, Morag, additional, Guiot, Marie-Christine, additional, McKinney, Anne, additional, Muller, William J., additional, Valiente, Manuel, additional, Petrecca, Kevin, additional, and Siegel, Peter M., additional

Published
2022
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15. Invasive growth associated with cold-inducible RNA-binding protein expression drives recurrence of surgically resected brain metastases

Author

Dankner, Matthew, primary, Caron, Maxime, additional, Al-Saadi, Tariq, additional, Yu, WenQing, additional, Ouellet, Véronique, additional, Ezzeddine, Rima, additional, Maritan, Sarah M, additional, Annis, Matthew G, additional, Le, Phuong Uyen, additional, Nadaf, Javad, additional, Neubarth, Noah S, additional, Savage, Paul, additional, Zuo, Dongmei, additional, Couturier, Charles P, additional, Monlong, Jean, additional, Djambazian, Haig, additional, Altoukhi, Huda, additional, Bourque, Guillaume, additional, Ragoussis, Jiannis, additional, Diaz, Roberto J, additional, Park, Morag, additional, Guiot, Marie-Christine, additional, Lam, Stephanie, additional, Petrecca, Kevin, additional, and Siegel, Peter M, additional

Published
2021
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23. A systematic review and meta-analysis of intrathecal versus alternate routes of delivery for HER2-targeted therapies in patients with HER2+ breast cancer leptomeningeal metastases.

Author

Lazaratos, Anna-Maria, Maritan, Sarah M., Darlix, Amelie, Ratosa, Ivica, Ferraro, Emanuela, Griguolo, Gaia, Pellerino, Alessia, Hofer, Silvia, Jacot, William, Stemmler, Hans-Joachim, van den Broek, Marcel, Panet, Francois, Lahijanian, Zubin, Morikawa, Aki, Seidman, Andrew David, Soffietti, Riccardo, Petrecca, Kevin, Rose, April A. N., Bouganim, Nathaniel, and Dankner, Matthew

Published
2023
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