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2. Protection against Rh D-haemolytic disease of the newborn by a diminished transport of maternal IgG to the fetus

Author

C. P. Engelfriet and Marion C. Dooren

Subjects
Placenta, Immunoglobulin E, Rh Isoimmunization, Immunoglobulin G, Erythroblastosis, Fetal, Pregnancy, medicine, Humans, Maternal-Fetal Exchange, Fetus, Rh-Hr Blood-Group System, biology, business.industry, Infant, Newborn, Biological Transport, Hematology, General Medicine, medicine.disease, Cytotoxicity Tests, Immunologic, medicine.anatomical_structure, Immunology, biology.protein, Female, Antibody, business, Rh blood group system
Abstract

IgG present in the circulation of newborn infants is predominantly of maternal origin. In cases of severe Rh D alloimmunization, the maternal anti-D anti-bodies may lead to Rh D-haemolytic disease of the newborn. However, an impaired placental transport of maternal IgG could be associated with the protection of the fetus/newborn against haemolytic disease as shown in this case report.

Published
1993

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