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With the development of nursing education institutions, there emerged a need for continued education and expansion of the body of related scientific knowledge. After the introduction of nursing care and nursing into the university curricula, scientific research in this area became an inevitable part of the advancement of the profession. Nursing focuses on the care for others and deals with issues such as nutrition, security and safety, admission and care, hygiene issues and similar. Promoting the research and involvement of nurses in research teams is of great importance to the quality of nurses' work, as it encourages evidence-based and data-based work. Generally speaking, we can say that the history of nursing research begins together with modern nursing. Nurses involved in research are often faced with a lack of support from managerial nurses and misunderstanding from colleagues who believe that doing research has a negative impact on clinical practice. Such a situation suggests that research work should actually be encouraged during school. There are three major areas with regard to nursing research: nursing education, nursing practice, and nursing administration. When it comes to trends in nursing education, the emphasis is primarily put on the importance of quality research rooted in philosophy and humanism that is also able to provide practically usable results. In the field of nursing practice, the emphasis is on research that promotes health and healthy lifestyles. Finally, in the field of nursing administration, the most common is evidence-based research. The primary focus is placed on topics such as nursing, energy therapies, knowledge and attitudes, and spirituality. The relationship between care and treatment, symptoms management, quality of life and depression are the topics most commonly examined. In Serbia, nurses have only recently been given the opportunity to study at a university level. There is also an increasing number of nursing colleges. This situation speaks in favor of stimulating and fostering research work.

Introduction. Opiates and opoids create physical and psychological addiction. Official statistics on the number of opiate addicts in Serbia doesn't exist. The United Nations Office on Drugs and Crime estimates that in 2014 some 29 million people in the world are dependent on some sort of drug. Method. This paper belongs to a group of review papers. Based on the key words (buprenorphine, substitution therapy, psychoactive substances), as well as various databases, isolated references were analyzed, systematized and presented in this paper. Discusion. Substitution therapy is most often used therapy method. Substitution therapy is a form of therapy in which an antagonist, a new substance with properties and actions of similar substances, is used. Agonists are used to provide a more controlled form of addiction. The most commonly used antagonist is methadone whose use in Europe reaches 90% of total opioid substitution, although it has been lately replaced by buprenorphine, a partial agonist-antagonist and is most commonly used in France. Researches show that buprenorphine causes less physical dependence than methadone and other substitutes. It also appears that there is less potential for drug abuse when buprenorphine is used instead of methadone. Conclusion. Many aspects of the effects of buprenorphine have not been fully tested. Social reintegration is an important aspect of social rehabilitation of opioid addicts, and it is therefore extremely important to recognize psychological and social factors that can act as protective factors, but also as risk factors. As the impact of buprenorphine on the outcomes of social rehabilitation has not been studied so far, it is necessary to design new studies that would go in this direction.