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2. The impact of nutritional intervention on quality of life and outcomes in patients with head and neck cancers undergoing chemoradiation

Author

Sara Cardellini, Chiara Lucrezia Deantoni, Matteo Paccagnella, Amanda Casirati, Andrea Pontara, Alessandro Marinosci, Moreno Tresoldi, Leone Giordano, Anna Chiara, Italo Dell’Oca, Nadia Gisella Di Muzio, Riccardo Caccialanza, and Aurora Mirabile

Subjects
head and neck cancer, nutritional counselling, oral nutritional supplement, quality of life, body composition, high-dose cisplatin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionChemoradiotherapy in head and neck cancer patients has a curative intent but often deteriorates nutritional status leading to sarcopenia and cachexia.MethodsIn this observational and single-centered study, a prospective evaluation of several biochemical and anthropometrical parameters, weight loss, handgrip strength, visual analogue scale of appetite, questionnaires associated with malnutrition & quality of life and body composition (obtained by Bioelectrical Impedance Vector Analysis) was performed before and after high-dose cisplatin chemotherapy combined with radiotherapy in 60 patients affected by head and neck cancer. Oral nutritional supplements were used to reach the correct number of daily calories and proteins.Results and discussionAll patients completed radiotherapy as planned and the 96,4% of them did not interrupt chemotherapy for toxicity, reaching a total dose of at least 200mg/m2. Despite a rapid deterioration of body composition during treatment, nutritional support helped patients to maintain (or in some cases improve) anthropometric parameters from the end of chemoradiotherapy to the following 3 months. Low prealbumin and albumin pre-treatment led to higher risk of toxicities with consequent reduction of cisplatin dose intensity, whereas weight at the end of the treatment seems to be an interesting predicting factor for disease free and overall survival (p=0.007; p=0.015).

Published
2024
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3. ISPRA Land and Soil Monitoring, Mapping, and Assessment Activities

Author

Munafò, Michele, De Fioravante, Paolo, Cimini, Angela, Riitano, Nicola, d’Antona, Marco, Di Leginio, Marco, Marinosci, Ines, Assennato, Francesca, Luise, Anna, Falconi, Marco, Vecchio, Antonella, Jacomini, Carlo, Dazzi, Carmelo, editor, Benedetti, Anna, editor, Corti, Giuseppe, editor, and Costantini, Edoardo A. C., editor

Published
2024
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4. Costs and acceptability of simplified monitoring in HIV-suppressed patients switching to dual therapy: the SIMPL’HIV open-label, factorial randomised controlled trial

Author

Annalisa Marinosci, Delphine Sculier, Gilles Wandeler, Sabine Yerly, Marcel Stoeckle, Enos Bernasconi, Dominique L. Braun, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Karin J. Metzner, Laurent Decosterd, Huldrych F. Günthard, Patrick Schmid, Andreas Limacher, Mattia Branca, and Alexandra Calmy

Subjects
Medicine
Abstract

BACKGROUND: Clinical and laboratory monitoring of patients on antiretroviral therapy is an integral part of HIV care and determines whether treatment needs enhanced adherence or modification of the drug regimen. However, different monitoring and treatment strategies carry different costs and health consequences. MATERIALS AND METHODS: The SIMPL’HIV study was a randomised trial that assessed the non-inferiority of dual maintenance therapy. The co-primary outcome was a comparison of costs over 48 weeks of dual therapy with standard antiretroviral therapy and the costs associated with a simplified HIV care approach (patient-centred monitoring [PCM]) versus standard, tri-monthly routine monitoring. Costs included outpatient medical consultations (HIV/non-HIV consultations), non-medical consultations, antiretroviral therapy, laboratory tests and hospitalisation costs. PCM participants had restricted immunological and blood safety monitoring at weeks 0 and 48, and they were offered the choice to complete their remaining study visits via a telephone call, have medications delivered to a specified address, and to have blood tests performed at a location of their choice. We analysed the costs of both strategies using invoices for medical consultations issued by the hospital where the patient was followed, as well as those obtained from health insurance companies. Secondary outcomes included differences between monitoring arms for renal function, lipids and glucose values, and weight over 48 weeks. Patient satisfaction with treatment and monitoring was also assessed using visual analogue scales. RESULTS: Of 93 participants randomised to dolutegravir plus emtricitabine and 94 individuals to combination antiretroviral therapy (median nadir CD4 count, 246 cells/mm3; median age, 48 years; female, 17%),patient-centred monitoring generated no substantial reductions or increases in total costs (US$ –421 per year [95% CI –2292 to 1451]; p = 0.658). However, dual therapy was significantly less expensive (US$ –2620.4 [95% CI –2864.3 to –2331.4]) compared to standard triple-drug antiretroviral therapy costs. Approximately 50% of participants selected one monitoring option, one-third chose two, and a few opted for three. The preferred option was telephone calls, followed by drug delivery. The number of additional visits outside the study schedule did not differ by type of monitoring. Patient satisfaction related to treatment and monitoring was high at baseline, with no significant increase at week 48. CONCLUSIONS: Patient-centred monitoring did not reduce costs compared to standard monitoring in individuals switching to dual therapy or those continuing combined antiretroviral therapy. In this representative sample of patients with suppressed HIV, antiretroviral therapy was the primary factor driving costs, which may be reduced by using generic drugs to mitigate the high cost of lifelong HIV treatment. Trial registration: ClinicalTrials.gov NCT03160105.

Published
2024
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6. Transgenerational cues about local mate competition affect offspring sex ratios in the spider mite Tetranychus urticae

Author

Duncan, Alison B., Marinosci, Cassandra, Devaux, Céline, Lefèvre, Sophie, Magalhães, Sara, Griffin, Joanne, Valente, Adeline, Ronce, Ophélie, and Olivieri, Isabelle

Subjects
local mate competition, sex-ratio, sib-mating, haplodiploid, Archaeology, CC1-960, Science
Abstract

In structured populations, competition for mates between closely related males, termed Local Mate Competition (LMC), is expected to select for female-biased offspring sex ratios. However, the cues underlying sex allocation decisions remain poorly studied. Here, we test for several cues in the spider mite Tetranychus urticae, a species that was previously found to adjust the sex ratio of its offspring in response to the number of females within the local population, i.e. a patch. We here investigate whether the offspring sex ratio of T. urticae females changes in response to 1) the current number of females in the same patch, 2) the number of females in the patches of their mothers and 3) their relatedness to their mate. Single females on patches produced similar sex ratios to those of groups of 15 females; their mothers had been in identical conditions of panmixia. The offspring sex ratios of females mated with their brother did not differ from those of females mated with an unrelated male. Females however produced a more female-biased offspring sex ratio if their mothers were alone on a patch compared to 15 other females. Thus, maternal environment is used as a cue for the sex allocation of daughters. We discuss the conditions under which the maternal environment may be a reliable predictor of LMC experienced by grand-sons.

Published
2023
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7. Designer Adhesives for Tough and Durable Interfaces in High‐Performance Ti‐Carbon PEKK Hybrid Joints

Author

Georgios Kafkopoulos, Vanessa M. Marinosci, Joost Duvigneau, Wouter J. B. Grouve, Sebastiaan Wijskamp, Matthijn B. deRooij, G. Julius Vancso, and Remko Akkerman

Subjects
adhesive bonding, APTES, C/PEKK, hot/wet conditioning resistance, polydopamine, polymer‐metal joint, Physics, QC1-999, Technology
Abstract

Abstract Advanced high‐performance structural applications require the right materials in the right place and suitable interface engineering. However, poor adhesion in harsh environmental conditions frequently challenge material interfaces. An example is the moisture sensitivity of titanium‐poly ether ketone ketone (PEKK) interfaces. Here, this work offers a high‐performance composite adhesive system, which combines strong adhesion and high interfacial toughness, particularly when used in metal‐polymer bonding. This system includes aminopropyl triethoxy silane (APTES)–polydopamine (SiPDA) layers, which can be formed on the titanium surface before the joining process with carbon fiber‐reinforced PEKK (C/PEKK). Adhesion between PEKK and titanium is evaluated before and after hot/wet conditioning using mandrel peel tests. This work discovers that applying thin SiPDA layers not only results in a remarkable rise in the interfacial fracture toughness but also provides durable bond stability after hot/wet conditioning. These findings indicate that polydopamine‐based coatings show great potential to achieve stable interfaces for the next generation of high‐performance metal‐polymer hybrid materials.

Published
2023
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10. Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency

Author

Damanti, Sarah, Ramirez, Giuseppe Alvise, Bozzolo, Enrica Paola, Da Prat, Valentina, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Marinosci, Alessandro, Scotti, Raffaella, Strada, Silvia, Scarpellini, Paolo, Castiglioni, Barbara, Oltolini, Chiara, Ripa, Marco, Din, Chiara Tassan, Centurioni, Clarissa Elisabeth, Di Scala, Flavia, Gobbi, Agnese, Alba, Ada Carla, Casiraghi, Giuseppina Maria, Morgillo, Anna, and Tresoldi, Moreno

Published
2022
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11. Recommendations for analgesia and sedation in critically ill children admitted to intensive care unit

Author

Amigoni, Angela, Conti, Giorgio, Conio, Alessandra, Corno, Manuela, Fazio, Paola Claudia, Ferrero, Federica, Gentili, Marta, Giugni, Cristina, L’Erario, Manuela, Masola, Maristella, Moliterni, Paola, Pagano, Giuseppe, Ricci, Zaccaria, Romagnoli, Stefano, Vasile, Beatrice, Vitale, Francesca, Marinosci, Geremia Zito, and Mondardini, Maria Cristina

Published
2022
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12. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

Author

Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. Srinath, Periago, Mirta Roses, Hanna, Pierre Abi, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez- Moreno, Carlos, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Genetu Bayih, Abebe, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting Soo, Como, Nadia, Eustace, Joe, Gabunia, Tamar, García, Patricia, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sybil, Medina, Marco, Mesa Rubio, Maria Lucia, Miranda Montoya, Maria Consuelo, Nel, Jeremy, Nunes, Estevao, Perola, Markus, Portoles, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan AC, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Ryan, Michael, Gjermeni, Nevila, Meta, Esmeralda, Aguila, Damian, Alonso, Ignacio, Altamirano, Marcos, Alvarez, María, Alzola, Rodrigo, Arce, Veronica, Arribillaga, Patricia, Avila, Rafael, Balbuena, Juan, Barcelona, Laura, Barletta, José, Benedetti, María, Berdiñas, Verónica, Burgui, Julieta, Caimi, Sabrina, Carrillo, Juan, Carrizo, Juan, Castelli, Juan, Cazaux, Alexis, Cervellino, Flavia, Chalco, Angelo, Chediack, Viviana, Cunto, Eleonora, D'Amico, Nicolàs, de Vedia, Lautaro, Delgado, Carolina, Di Pilla, Debora, Díaz, Miguel, Díaz Aguiar, Pablo, Domínguez, Cecilia, Ellero, Leonor, Farina, Javier, Fernàndez, José, Ferreyra, Roxana, Filippi, María, Fogar, Carolina, Frare, Pablo, Giudiche, Celeste, Golikow, Mariana, Gomez, Maria Georgina, Hermida, Laura, Hurtado, Mariano, Jacobo, Mariela, Jaume, Martin, Laplume, Diego, Lescano, María, Lista, Nicolàs, Loiacono, Flavia, López, Ana Belen, Losso, Marcelo, Luna, Cecilia, Lupo, Sergio, Marianelli, Leonardo, Martin, Anabella, Masciottra, Florencia, Mykietiuk, Analía, Orellano, Lorena, Pachioli, Valeria, Padilla, María José, Pallavicini, Cecilia, Patroso, Jazmin, Perez Blanco, Luz, Presas, Jose Louis, Provenzano, Matias, Lavera, Lorena, Reichert, Viviana, Riveros, Florencia, Rodríguez, Alejandra, Rolon, María José, Salvay, Carolina, Simonetta, María, Sisto, Alicia, Themines, Sandra, Tito, Fernando, Toibaro, Javier, Torales, Graciela, Verón, Luciano, Vizzotti, Carla, Egle, Alexander, Greil, Richard, Joannidis, Michael, Altdorfer, Antoine, Belkhir, Leila, Fraipont, Vincent, Hites, Maya, Arruda, Erico, Breda, Giovanni, Colussi, Arthur, Corradi, Miran, Croda, Julio, Duani, Helena, João, Esaú, Machado, Elizabeth, Mello, Fernanda, Miranda Filho, Demócrito, Monteiro, Poliana, Nunes, Ceuci, Pereira Junior, Luiz Carlos, Pinto, Gustavo, Raboni, Sonia, Ramos, Marcelo, Ruffing, Leonardo, Santos, Valdilea, Souza, Tamara, Medeiros, Melissa, Schwarzbold, Alexandre, Ali, Karim, Azher, Tanweer, Bellemare, David, Binnie, Alexandra, Borgia, Sergio, Cavayas, Yiorgos Alexandros, Chagnon, Nicholas, Cheng, Matthew, Cloutier, Eve, Conly, John, Costiniuk, Cecilia, Daneman, Nick, Douglas, James, Downey, Catarina, Duan, Erick, Durand, Medeline, English, Shane, Farjou, George, Fera, Evadiki, Fontela, Patricia, Fowler, Rob, Fralick, Mike, Gamble, David Gregory, Geagea, Anna, Grant, Jennifer, Harrison, Luke, Havey, Thomas, Hoang, Holly, Kelly, Lauren, Keynan, Yoav, Khwaja, Kosar, Klein, Marina, Kolan, Christophe, Kronfli, Nadine, Lamontagne, Francois, Lee, Nelson, Lee, Todd, Lim, Rachel, Lostun, Alexandra, MacIntyre, Erika, Malhamé, Isabelle, Martin-Carrier, Francois, McGuinty, Marlee, Munan, Matthew, O'Neil, Conar, Ovakim, Daniel, Papenburg, Jesse, Parhar, Ken, Parvathy, SeemaNair, Perez-Patrigeon, Santiago, Rishu, Asgar, Rushton, Moira, Scherr, Kim, Schwartz, Kevin, Semret, Makeda, Silverman, Micahel, Singh, Ameeta, Sligl, Wendy, Smith, Stephanie, Somayaji, Ranjani, Tan, Darrell, Tran, Tuong-Vi, Tremblay, Alain, Tsang, Jennifer, Turgeon, Alexis, Vakil, Erik, Weatherald, Jason, Yansouni, Cedric, Zarychanski, Ryan, Aristizabal, Claudia, Bravo, Juan, Caicedo, Monica, Chacón, Julio, Garzón, Diego, Guevara, Fredy, Lozano-Gonzàlez, Silvia, Macareno, Hugo, Montañez-Ayala, Anita, Oñate, Jose, Rojas-Gambasica, Jose, Rosso, Fernando, Saavedra, Carlos, Valderrama, Sandra, Vàquiro-Herrera, Eliana, Varón-Vega, Fabio, Zuluaga, Ivan, Abdel Baki, Amin, Abdelbary, Akram, Abdel-Razek, Wael, Amin, Wagdi, Asem, Noha, Elassal, Gehan, Elshesheny, Marwa, Fathy, Mohamed, Fathy, Naglaa, Fayed, Notaila, Hammam, Ahmed, Hassany, Sahar, Ibrahim, Hamdy, Kamal, Ehab, Masoud, Hossam, Mohamed, Maryam, Mohamed Gouda, Abdullah, Moustafa, Ehab, Okasha, Shaimaa, Rafik, Ahmed, Said, Ahmed, Sedky, Asmaa, Solyman Kabil, Mohamed, Tarek, Sara, Tharwat, Ahmed, Zaky, Samy, Abegaz, Emawayish Tesema, Bekele, Zelalem Mekonnen, Asfaw, Filmona Mekuria, Tegegne, Netsanet Aragaw, Teklemariam, Miheret Fikre, Nigusse, Frehiwot Tamiru, Achalu, Daniel Legesse, Weldegergs, Shewit Tesfagabr, Huluka, Dawit Kebede, Tereda, Addisu Birhanu, Ala-Kokko, Tero, Delany, Jutta, Ekroos, Heikki, Hankkio, Riina, Haukipää, Mia, Hetemäki, Iivo, Holma, Pia, Holmberg, Ville, Horstia, Saana, Jalkanen, Ville, Jämsänen, Toni, Järventie, Juuso, Järvinen, Petrus, Kalliala, Ilkka, Kauma, Heikki, Kilpeläinen, Tuomas, Kreivi, Hanna-Riikka, Kuitunen, Ilari, Lamminmäki, Satu, Mäkinen, Laura, Mäntylä, Jarkko, Mattila, Tiina, Myllärniemi, Marjukka, Niskanen, Joni, Nykänen, Taina, Nyqvist, Miro, Paajanen, Juuso, Partanen, Terhi, Patovirta, Riitta-Liisa, Paukkeri, Erja-Leena, Puusti, Emmi, Renner, Andreas, Reponen, Emma, Risku, Sari, Rosberg, Tuomas, Rutanen, Jarno, Säilä, Petrus, Salonen, Päivi, Sinisalo, Marjatta, Sivenius, Katariina, Tuominen, Susanna, Aboab, Jerone, Alfaiate, Toni, Andrejak, Claire, Andreu, Pascal, Belhadi, Drifa, Benezit, Francois, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bougon, David, Bouiller, Kevin, Bounes, Fanny, Boyer, Alexandre, Bruel, Cédric, Buffet, Alexandre, Burdet, Charles, Cazanave, Charles, Chabertier, Cyrille, Clere-Jehl, Rapahel, Costagliola, Dominique, Courjon, Johan-Victor, Crockett, Flora, Danion, Francois, Dechanet, Aline, Dellamonica, Jean, Delmas, Christelle, Diallo, Alpha, Djossou, Felix, Dubost, Clement, Dupont, Axelle, Epaulard, Olivier, Faure, Emmmanuel, Faure, Karine, Fayol, Antoine, Figueiredo, Samy, Fougerou, Claire, Gaborit, Benjamin, Gaci, Rostane, Gagneux-Brunon, Amandine, Gallien, Sebastien, Garot, D, Goehringer, Francois, Gruson, Didier, Hinschberger, Olivier, Hulot, Jean-Sebastien, Jaureguiberry, Stephane, Jean-Michel, Vanessa, Kerneis, Solen, Kimmoun, Antoine, Klouche, Kada, Lachatre, Marie, Lacombe, Karine, Laine, Fabrice, Lanoix, Jean Philippe, Laribi, Samira, Launay, Odile, Laviolle, Bruno, Le Moing, Vincent, Le Pavec, Jerome, Lebeaux, David, Leroy, Sylvie, Lescure, Xavier, Livrozet, Marine, Makinson, Alain, Malvy, Denis, Marquette, Charles-Hugo, Martin-Blondel, Guillaume, Mayaux, Julien, Mekontso Dessap, Armand, Mentre, France, Mercier, Noemie, Meziani, Ferhat, Molina, Jean Michel, Mootien, Yoganaden, Mourvillier, Bruno, Navellou, Jean Christoph, Noret, M, Peiffer- Smadja, Nathan, Peytavin, Gilles, Pialoux, Gilles, Pilmis, Benoît, Piroth, Lionel, Poindron, Vincent, Poissy, Julien, Pourcher, Valerie, Quenot, Jean Pierre, Raffi, Francois, Reignier, Jean, Richard, Jean Christoph, Robert, Céline, Saillard, Juliette, Sayre, Naomi, Senneville, Eric, Stefan, Francois, Tellier, Marie Capucine, Terzi, Nicolas, Textoris, Julien, Thiery, Guillame, Timsit, Jean Francois, Tolsma, Violaine, Tubiana, Sarah, Wallet, Florent, Yazdanpanah, Yazdan, Zerbib, Yoann, Aguilar, Carlos, Erazo, Laura, Fiallos, Angel, Figueroa, Rosbinda, Flores, Juan Jose, Melendez, Lesddyy, Moncada, Wendy, Abraham, Ooriapadickal Cherian, Acharya, Chetankumar, Aedula, Vinaya Sekhar, Aggarwal, Richa, Agrawal, Nishant, Agrawal, Umang, Agrawal, Abhishekh, Ahmad, Mohammad, Atal, Shubham, Babu, Avinash, Baidya, Dalim Kumar, Balachandran, Amith, Bangar, Rakhee, Bhadade, Rakesh, Bhandari, Sudhir, Bhapal, Meghavi, Bhardwaj, Pankaj, Bhati, Gaurav, Bhatia, Pradeep, Bhatt, Krishnakant, Bingi, Thrilok Chander, Borse, Rohidas, Buch, Vyom, Chand, Dipti, Chandwani, Ashish, Charan, Jaykaran, Chaudhari, Mayur, Chaudhari, Kirti, Chaudhary, Vipul, Chauhan, Nishant, Chikara, Gaurav, Daswani, Bharti, de Souza, Rosemarie, Desai, Chetna, Divakar, Balusamy, Divhare, Sujeet, Dorairajan, Suresh Kumar, Dutt, Naveen, Ethirajan, Therani Rajan, Gamit, Amit, Gamit, Sweta, Garg, Mahendra, Goenka, Ajay, Goenka, Aniket, Guleria, Randeep, Gupta, Paras, Gupta, Nivedita, Gupta, Madhur, Harde, Minal, Ingle, Vaibhav, Iyer, Shivkumar, Jamalapuram, Vaishnavi, Jayanthi, Rangarajan, Joshi, Rajnish, Kadam, Abhijeet, Kalakuntla, Hemanth, Kalikar, Mrunalini, Kalme, Sayali, Kamble, Suchit, Kant, Ravi, Kantharia, Bansari, Kashikar, Arundhati, Kavishvar, Abhay, Kayina, Choro Athipro, Kerkar, Pranali, Khadanga, Sagar, Khandare, Sagar, Kokate, Pranjali, Komathi, Jayavelu, Krishnan, Vijay, Krishnan, Jayasree, Krishnan, Sumitra, Kulur Mukhyaprana, Sudha, Kumarasamy, N, Mahavar, Sunil, Maitra, Souvik, Majumdar, Falguni, Malhotra, Supriya, Mamulwar, Megha, Malini, Padma, Marwah, Vikas, Maurya, Akhilesh, Mehta, Kedar, Mesipogu, Rajarao, Misra, Shobha, Mitra, Sajal, Mittal, Ankit, Mohan, Bharathi, Momin, Mohmmedirfan, Nag, Vijaya, Nagarajan, Ramakrishnan, Nagmani, Kammili, Narlawar, Uday, Natarajan, Gopalakrishnan, Nischal, Neeraj, Ogale, Dhananjay, Palat, Paltial, Panda, Prasan, Panda, Samiran, Pandya, Amee, Parate, Rohit, Paritekar, Arunita, Patel, Parvati, Patel, Chetna, Patel, Sunaina, Patel, Vitan, Patel, Deep, Patel, Harshad, Patil, Girish, Peter, Deepu, Prasad, Durga, Purohit, Vimlesh, Rabindrarajan, Ebenezer, Ranganathan, Lakshmiarasimhan, Rao, Tushara, Rao, Chakradhara, Rathod, Chirag, Raval, Devang, Ray, Avik, Reddy, Kamini, Rege, Sujata, Revathi, Ayyasamy, Roy, Dhara, Saigal, Saurabh, Sane, Suvarna, Sangale, Shashi, Seetharaman, Krishnamoorthy, Selvamuthu, Poongulali, Seshaiah, Kurada Venkata, Shadrach, Benhur, Shah, Jignesh, Shah, Sonal, Sharma, Swati, Sharma, Raman, Sharma, Shrikant, Singh, Krishna, Singh, Anil, Singh, Arjeet, Singhai, Abhishek, Soneja, Manish, Soni, Kapil Dev, Subhan, Thasneem banu, Subramaniam, Sudharshini, Sudarsanam, Thambu David, Sudarsi, Ravindra Kumar, Suleman, Dawood, Suthar, Nilay, Talati, Shriraj, Tambe, Murlidhar, Tejomurtula, Tilak, Tirupakuzhi Vijayaraghavan, Bharatkumar, Trikha, Anjan, Trivedi, Aarti, Udwadia, Zarir, Upadhyay, Kamlesh, Vasava, Ashwin, Vasudevan, Damodaran, Velayudham, Rajendran, Venkatasubramanian, Ramasubramanian, Verma, Mamta, Waghmare, Rakesh, Waikar, Anushka, Wig, Naveet, Afrilia, Annisa Rizky, Amin, Muhammad, Arlinda, Dona, Avrina, Rossa, Bang, Lois, Djaharuddin, Irawaty, Djojo, Aryan, Driyah, Sri Laning, Erastuti, Mila, Fajarwati, Tetra, Harsini, Harsini, Hartantri, Yovita, Herman, Deddy, Isbaniah, Fathiyah, Karyana, Muhammad, Kusuma, Indra, Mahmudji, Harli Amir, Medison, Irvan, Nugroho, Agung, Nurhayati, Nurhayati, Opitasari, Cicih, Pitoyo, Ceva Wicaksono, Pradana, Antonius Arditya, Raharjo, Sofyan Budi, Rahmaini, Ade, Risniati, Yenni, Riyanto, Bambang Sigit, Sajinadiyasa, I Gede Ketut, Sari, Flora Eka, Sitompul, Pompini Agustina, Soedarsono, Soedarsono, Somia, I Ketut Agus, Sugiri, Yani Jane, Sugiyono, Retna Indah, Susanto, Nugroho Harry, Syarif, Armaji Kamaludi, Yulianto, Aris, Afsharian, Mandana, Akhavi Mirab, Atefehsadat, Amini, Fatemeh, Amini, Mahnaz, Ansarin, Khalil, Baba Mahmoodi, Farhang, Baghaei, Parvaneh, Barazandeh, Fateme, Bayani, Masomeh, Dastan, Farzaneh, Ebrahimpour, Soheil, Eghtesad, Sareh, Fallahi, Mohammad Javad, Fallahpoor Golmaee, Fatemeh, Foroghi Ghomi, Seyed Yaser, Ghadir, Mohammad Reza, Gheitani, Mina, Ghiasvand, Fereshteh, Hafizi Lotfabadi, Saied, Hakamifard, Atousa, Hashemi Madani, Shima Sadat, Hormati, Ahmad, Hosseini, Hamed, Janbakhsh, Alireza, Javanian, Mostafa, Joukar, Farahnaz, Kamali, Alireza, Karampour, Amin, Khajavirad, Nasim, Khodabakhshi, Behnaz, Khodadadi, Javad, Khodashahi, Rozita, Kiani Majd, Somaieh, Mahfoozi, Lida, Mahmoodiyeh, Behnam, Mansour-Ghanaei, Fariborz, Mansouri, Feizollah, Mesgarpour, Bita, Mesri, Mehdi, Mikaeili, Haleh, Miladi, Ronak, Moghadami, Mohsen, Mohamadi, Payam, Mohraz, Minoo, Mohseni Afshar, Zeinab, Moogahi, Sasan, Mousavi Anari, Seyed Alireza, Mozaffar, Seyyed Hassan, Mozdourian, Mahnaz, Najafipour, Reza, Najari, Hamidreza, Nazemiyeh, Masoud, Norouzi, Alireza, Pourkazemi, Aydin, Poustchi, Hossein, Saberhosseini, Seyedeh Naeimeh, Saberi, Marzieh, Saber-Moghaddam, Niloufar, Sadeghi, Anahita, Sadeghi Haddad Zavareh, Mahmoud, Sahraian, Mohammad Ali, Salahi, Mehrdad, Salehi, Mohammad Reza, Sarmadian, Hossein, Sayad, Babak, Shirani, Kiana, Shirvani, Maria, Shojaei, Daryanaz, Shokri, Mehran, Siami, Zeinab, Sima, Ali Reza, Soleimani, Alireza, Soltanmohammad, Saedeh, Tabarsi, Payam, Taghizadieh, Ali, Tavassoli, Samaneh, Varnasseri, Mehran, Vaziri, Siavash, Yadyad, Mohammad Jaafar, Yaghoubi, Shoeleh, Yazdanpanah, Yalda, Yousefi, Farid, Zamanian, Mohammad Hossein, Zand, Farid, Zare Hoseinzade, Elham, Bergin, Colm, Cotter, Aoife, de Barra, Eoghan, Jackson, Arthur, Laffey, John, McCarthy, Cormac, Muldoon, Eavan, Sadlier, Corinna, Maguire, Teresa, Angheben, Andrea, Bai, Francesca, Bandera, Alessandra, Barchiesi, Francesco, Bassetti, Matteo, Bisi, Luca, Bonfanti, Paolo, Calò, Federica, Campoli, Caterina, Canovari, Benedetta, Capetti, Amedeo, Castelli, Francesco, Cauda, Roberto, Cingolani, Antonella, Cocco, Nicolò, Coppola, Nicola, Corcione, Silvia, Cremonini, Eleonora, d'Arminio Monforte, Antonella, de Gaetano Donati, Katleen, De Nardo, Pasquale, De Rosa, Francesco Giuseppe, Degioanni, Maria, Della Siega, Paola, Di Bella, Stefano, Drera, Bruno, Focà, Emanuele, Fornabaio, Chiara, Galli, Massimo, Giacomazzi, Donatella, Gori, Andrea, Gustinetti, Giulia, Iannuzzi, Francesca, Kertusha, Blerta, Lamonica, Silvia, Lichtner, Miriam, Lupia, Tommaso, Luzzati, Roberto, Macera, Margherita, Menatti, Elisabetta, Merelli, Maria, Merlini, Esther, Monari, Caterina, Pan, Angelo, Pecori, Davide, Pezzani, Diletta, Riccardi, Niccolò, Rodari, Paola, Roldan, Eugenia, Rovere, Pierangelo, Rusconi, Stefano, Scabini, Silvia, Tascini, Carlo, Viale, Pierluigi, Vincenzi, Marcello, Zuccalà, Paola, Zucchi, Patrizia, Al-Roomi, Moudhi, Al-Sabah, Salman, Schrapp, Kelly, Hassoun, Mahmoud, Matar, Madonna, Dbouni, Oussaima, Yared, Nadine, Saliba, Michele, Farra, Anna, Riachi, Moussa, Zablockiene, Birute, Reuter, Jean, Staub, Therese, Ab Wahab, Suhaila, Chew, Chun Keat, Chua, Hock Hin, Goh, Pik Pin, Lee, Heng Gee, Leong, Chee Loon, Low, Lee Lee, Mak, Wen Yao, Mohamed Gani, Yasmin, Muhamad, Dzawani, Zaidan, Nor Zaila, Ducker, Camilla, Demiri, Ilir, Aballi, Saad, Berg, Åse, Blomberg, Bjørn, Dalgard, Olav, Dyrhol-Riise, Anne Ma, Eiken, Ragnhild, Ernst, Gernot, Hannula, Ranula, Haugli, Metter, Heggelund, Lars, Hoel, Hedda, Hoff, Dag Arne Lihaug, Holten, Aleksander Rygh, Johannessen, Asgeir, Kåsine, Trine, Kildal, Anders Benjamin, Kittang, Bård Reikvam, Nezvalova-Henriksen, Katerina, Olsen, Inge Christoffer, Olsen, Roy Bjørkolt, Skei, Nina Vibeche, Skudal, Hilde, Tholin, Birgitte, Thoresen, Lars, Trøseid, Marius, Tveita, Anders, Vinge, Leif, Ystrøm, Carl Magnus, Al Jahdhami, Issa, AlNaamani, Khalid, Al Balushi, Zakariya, Pandak, Nenad, Abbas, Salma, Akhtar, Nasim, Azam, Sumeyya, Begum, Dilshad, Hassan, Sadia, Herekar, Fivzia, Khan, Shahzaib, Khan, Ejaz Ahmed, Mahmood, Syed Faisal, Nasir, Nosheen, Rahim, Anum, Sarfaraz, Samreen, Shaikh, Qurat-ul-Ain, Sultan, Faisal, Walayat, Usman, Agurto-Lescano, Erika Cecilia, Alcantara-Díaz, Andrés Martín, Alva-Correa, Ana María, Alvarado-Moreno, José Gustavo, Ángeles-Padilla, Bethsabé, Arbañil-Huamàn, Hugo César, Ávila-Reyes, Pool Christopher, Azañero-Haro, Johan Alexander, Barreto-Rocchetti, Luis Guillermo, Benitez-Peche, Jorge Marko A., Bernal-Màlaga, Karla Hortencia, Cabrera-Portillo, Liliana Norma, Carazas-Chavarry, Reynaldo Javier, Càrcamo, Paloma Mariana, Casimiro-Porras, Indira Catalina, Castillo-Espinoza, Jhuliana, Chacaltana-Huarcaya, Jesús Norberto, Cornejo-Valdivia, Carla Raquel, Cruz-Chereque, Augusto, Del-Aguila-Torres, Keith Cayetano Marcelino, Díaz-Chipana, Erika, Flores-Valdez, Neil, Franco-Vàsquez, Rosanna Andrea, Gallegos-López, Roxana Consuelo, Gastiaburú-Rodriguez, Dauma Yesenia, Gianella-Malca, Gonzalo Ernesto, Gomero-Lopez, Andrés Alonso, Hercilla-Vàsquez, Luis Enrique, Hueda-Zavaleta, Miguel Ángel, Ibarcena-Llerena, Claudia Vanessa, Iberico-Barrera, Carlos Alberto, Inquilla-Castillo, Miguel Angel, Juàrez-Eyzaguirre, Jesus Alberto, Laca-Barrera, Manuel, León-Jiménez, Franco, Luna-Wilson, Carla Vanessa, Màlaga, German, Marin, Ricardo, Mejía-Cordero, Fernando, Mendoza-Laredo, Juan Arturo, Meregildo-Rodríguez, Edinson Dante, Miranda-Manrique, Gonzalo Francisco, Olivera-Chaupis, Marco, Ortega-Monasterios, Fatima Josefina, Otazú-Ybàñez, Jimmy Pedro, Paredes-Moreno, María Angélica, Peña-Mayorga, Claudia Ximena, Peña-Vàsquez, Olivia del Carmen, Peña-Villalobos, Alejandro, Ponce, Oscar J, Ponte-Fernandez, Katherin Estefania, Pro, Jose, Quispe-Nolazco, César Miguel, Ramos-Samanez, Manuel Efrain, Rojas-Murrugarra, Kory Mirtha, Samanez-Pérez, Jorge Mauro, Sànchez-Carrillo, Halbert Chrostian, Sànchez-Garavito, Epifanio, Sànchez-Sevillano, Ricardo Manuel, Sandoval-Manrique, Hernan, Santos-Revilla, Gabriela, Silva-Ramos, Julio Antonio, Solano-Ico, Manuel Alberto, Soto, Alonso, Sotomayor-Woolcott, Giannilu Michelle, Tapia-Orihuela, Ruben Kevin Arnold, Terrazas-Obregón, Carmen Sara, Terrones-Levano, Victor Francisco, Ticona-Huaroto, Cesar Eduardo, Torres-Ninapayta, Walter, Torres-Ruiz, Oscar Martin, Ugarte-Mercado, Dario, Vargas-Anahua, Orlando José, Vàsquez-Becerra, Ruben Dario, Vàsquez-Cerro, José Gabriel, Villegas-Chiroque, Miguel, Williams, Anna Larson, Yauri-Lazo, Randi Mauricio, Abad, Cybele Lara, Andales-Bacolcol, Silverose Ann, Arcegono, Marlon, Arches, Jamie, Astudillo, Mary Grace, Aventura, Emily, Awing, Arlyn, Bala, Mishelle Vonnabie, Bello, Jia An, Blanco, Peter, Benedicto, Jubert, Buno, Susana, Cabrera, Justine, Cajulao, Thea Pamela, Caoili, Janice, Casiple-Amsua, Lina, Catambing, Victor, Chin, Inofel, Chua, Ma. Bernadette, Chua, Mitzi Marie, Climacosa, Fresthel Monica, David-Wang, Aileen, De los Reyes, Virginia, Europa, Gilly May, Fernandez, Lenora, Francisco, Jorge, Garcia, Gerard, Garcia, Jemelyn, Gler, Maria Tarcela, Isidro, Marie Grace Dawn, Javier, Rozelle Jade, Kwek, Marion, Lansang, Mary Ann, Lee, Aileen, Li, Kingbherly, Llanes, Mark Ramon Victor, Llorin, Ryan, Macadato, Omar Khayyam, Malundo, Anna Flor, Mercado, Maria Elizabeth, Mujeres, Mercedes, Nepomuceno, Marisse, Ngo-Sanchez, Katha, Orden, Mary Claire, Pablo-Villamor, Maria Philina, Paez, Ruel Dionisio, Palmes, Patricio, Panaligan, Marion, Quinivista-Yoon, Jenny Mae, Ramos, Mary Shiela Ariola, Ramos -Penalosa, Christine, Reyes, Sheila Marie, Roa, Kathryn, Roman, Arthur Dessi, Rosario, Minette Claire, Roxas, Evalyn, Santos, Lourdes Ella Gonzales, Soldevilla, Helmar, Solante, Rontgene, Suaco, Jane, Tagarda, Daisy, Tang, Issa Rufina, Te, Bob, Teo, Dennis, Tibayan, Christopher John, Villalobos, Ralph Elvi, Ymbong, Duane Richard, Zabat, Gelza Mae, Batkova, Stepanka, Cardoso, Orlando, Garrote, Ana-Raquel, Lino, Sara, Manata, Maria-José, Pinheiro, Helder, Póvoas, Diana, Ramirez, Freddy, Seixas, Diana, Naji, Assem, Al Gethamy, M Al, AL-Mulaify, Mohammed Sami, Al Maghraby, Reem, Alrajhi, A, Al Sharidi, Aynaa, Alotaibi, Naif, AlShaharani, F, Barry, Mazin, Ghonem, Leen, Khalel, Anas, Kharaba, Ayman Mohammed, Alabdan, Lulwah, AlAbdullah, Mohammed Sharaf, Al Shabib, Abdullah, Bengu, Simangele, Bennet, Jacklyn, Dubula, Thozama, Howell, Pauline, Janse van Vuuren, Cloete, Kalla, Ismail, Lifson, Aimee, Maasdorp, Shaun, Magua, Nombulelo, Maluleke, Vongani, Mbhele, Nokuphiwa, Mdladla, Nathi, Mendelson, Mark, Menezes, Colin, Mwelase, Thando, Nchabeleng, Maphoshane, Palanee-Phillips, Thesla, Parker, Victoria, Rassool, Mohammed, Reeder, Paul, Sossen, Bianca, Steyn, Dewald, Tsitsi, Merika, van Blydenstein, Sarah Alex, Venter, Michelle, Van Vuuren, Janse, Venturas, Jacquie, Abad Pérez, Daniel, Abenza, Maria José, Alarcón-Payer, Carolina, Armero Garrigos, Eva, Arribas, Jose Ramon, Ascaso, Ana, Berenguer, Juan, Cabello-Clotet, Noemí, Chamorro Tojeiro, Sandra, Cuenca-Acevedo, Rafael, de la Calle, Fernando, Del Toro, Maria Dolores, Díaz Pollàn, Beatriz, Diez, Cristina, Esquillor-Rodrigo, María José, Estrada, Vicente, Fanciulli, Chiara, Fanjul, Francisco, Fernàndez de Orueta, Lucía, Ferre, Adrian, Ferreira Pasos, Eva Maria, Gainzarain-Arana, Juan-Carlos, Garcia, Felipe, García Deltoro, Miguel, Goikoetxea Agirre, Ane Josune, Gómez Barquero, Julia, Gomez-Huelgas, Ricardo, Gonzàlez Moraleja, Julio, Guijarro, Carlos, Gutierrez, Felix, Guzmàn, Jesús, Ibarguren, Maialen, Iribarren, Jose Antonio, Jerusalem, Koen, Juan Arribas, Arturo, Lalueza, A, Leone, Antonio, Lopez Azkarreta, Iñigo, Lozano-Martin, Daniel, Lucendo, Alfredo J, Luengo López, Mariella, Martín Oterino, JA, Masa, JF, Merino, Esperanza, Monge-Maillo, Begoña, Moran-Rodríguez, Miguel-Angel, Muñez Rubio, Elena, Muñoz Sanchez, Josefa, Nuñez Orantos, Maria Jose, Nuño, Enrique, Ortiz-De-Zarate-Ibarra, Zuriñe, Pagàn-Muñoz, Bàrbara, Paño-Pardo, José Ramón, Peñaranda, Maria, Pérez Chica, Gerardo, Pérez Fernàndez, AM, Pérez-López, Carmen, Polo San Ricardo, Victor, Portu-Zapirain, Joseba, Puchades, Francesco, Rivas Paterna, Ana Belen, Rodríguez Vidigal, Francisco F, Rodríguez-Baño, Jesus, Ruiz-Seco, Pilar, Ryan, Pablo, Saez-De-Adana, Ester, Salas, Rosario, Salavert Lletí, Miguel, Sandoval, Raquel, Toyas-Miazza, Carla, Valencia, Jorge, Vargas, Emilio, Velasco, Maria, Von Wichmann, Miguel Angel, Bosshard, Andreas, Calmy, Alexandra, Castro, Tiago, Cavassini, Matthias, Clerc, Olivier, Conen, Anna, Desbaillets, Nicolas, Desgranges, Florian, Duss, Francois, Emonet, Stephane, Erard, Veronique, Eyer, Myriam, Fayet-Mello, Aurélie, Flammer, Yvonne, Friedl, Andrée, Fulchini, Rosamaria, Furrer, Hansjakob, Garin, Nicolas, Gastberger, Salome, Greiner, Michael, Haefliger, David, Haubitz, Sebastian, Hoffmann, Matthias, Isenring, Egon, Jakopp, Barbara, Lampert, Markus, Marinosci, Annalisa, Martin, Yvonne, Petignat, Pierre-Auguste, Piso, Rein Jan, Prendki, Virginie, Rutishauser, Jonas, Schaefer, Elisabeth, Schmiedel, Yvonne, Schwery, Stefan, Stavropoulou, Elisavet, Stoeckle, Marcel, Suttels, Veronique, Thurnher, Maria Christine, van den Bogaart, Lorena, West, Emily, Wiegand, Jan, and Wiggli, Benedikt

Published
2022
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13. The impact of nutritional intervention on quality of life and outcomes in patients with head and neck cancers undergoing chemoradiation.

Author

Cardellini, Sara, Deantoni, Chiara Lucrezia, Paccagnella, Matteo, Casirati, Amanda, Pontara, Andrea, Marinosci, Alessandro, Tresoldi, Moreno, Giordano, Leone, Chiara, Anna, Dell'Oca, Italo, Di Muzio, Nadia Gisella, Caccialanza, Riccardo, and Mirabile, Aurora

Subjects
BODY composition, NUTRITION counseling, WEIGHT loss, PROGRESSION-free survival, DIETARY supplements, HEAD & neck cancer
Abstract

Introduction: Chemoradiotherapy in head and neck cancer patients has a curative intent but often deteriorates nutritional status leading to sarcopenia and cachexia. Methods: In this observational and single-centered study, a prospective evaluation of several biochemical and anthropometrical parameters, weight loss, handgrip strength, visual analogue scale of appetite, questionnaires associated with malnutrition & quality of life and body composition (obtained by Bioelectrical Impedance Vector Analysis) was performed before and after high-dose cisplatin chemotherapy combined with radiotherapy in 60 patients affected by head and neck cancer. Oral nutritional supplements were used to reach the correct number of daily calories and proteins. Results and discussion: All patients completed radiotherapy as planned and the 96,4% of them did not interrupt chemotherapy for toxicity, reaching a total dose of at least 200mg/m2. Despite a rapid deterioration of body composition during treatment, nutritional support helped patients to maintain (or in some cases improve) anthropometric parameters from the end of chemoradiotherapy to the following 3 months. Low prealbumin and albumin pre-treatment led to higher risk of toxicities with consequent reduction of cisplatin dose intensity, whereas weight at the end of the treatment seems to be an interesting predicting factor for disease free and overall survival (p=0.007; p=0.015). [ABSTRACT FROM AUTHOR]

Published
2024
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14. Recommendations for analgesia and sedation in critically ill children admitted to intensive care unit

Author

Angela Amigoni, Giorgio Conti, Alessandra Conio, Manuela Corno, Paola Claudia Fazio, Federica Ferrero, Marta Gentili, Cristina Giugni, Manuela L’Erario, Maristella Masola, Paola Moliterni, Giuseppe Pagano, Zaccaria Ricci, Stefano Romagnoli, Beatrice Vasile, Francesca Vitale, Geremia Zito Marinosci, and Maria Cristina Mondardini

Subjects
Sedation, Paediatric intensive care unit, Pain, Substance withdrawal syndrome, Delirium, Anesthesiology, RD78.3-87.3, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract We aim to develop evidence-based recommendations for intensivists caring for children admitted to intensive care units and requiring analgesia and sedation. A panel of national paediatric intensivists expert in the field of analgesia and sedation and other specialists (a paediatrician, a neuropsychiatrist, a psychologist, a neurologist, a pharmacologist, an anaesthesiologist, two critical care nurses, a methodologist) started in 2018, a 2-year process. Three meetings and one electronic-based discussion were dedicated to the development of the recommendations (presentation of the project, selection of research questions, overview of text related to the research questions, discussion of recommendations). A telematic anonymous consultation was adopted to reach the final agreement on recommendations. A formal conflict-of-interest declaration was obtained from all the authors. Eight areas of direct interest and one additional topic were considered to identify the best available evidence and to develop the recommendations using the Evidence-to-Decision framework according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. For each recommendation, the level of evidence, the strength of the recommendation, the benefits, the harms and the risks, the benefit/harm balance, the intentional vagueness, the values judgement, the exclusions, the difference of the opinions, the knowledge gaps, and the research opportunities were reported. The panel produced 17 recommendations. Nine were evaluated as strong, 3 as moderate, and 5 as weak. Conclusion: a panel of national experts achieved consensus regarding recommendations for the best care in terms of analgesia and sedation in critically ill children.

Published
2022
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15. Predictors of Pneumothorax/Pneumomediastinum in Mechanically Ventilated COVID-19 Patients

Author

Belletti, Alessandro, Palumbo, Diego, Zangrillo, Alberto, Fominskiy, Evgeny V., Franchini, Stefano, Dell'Acqua, Antonio, Marinosci, Alessandro, Monti, Giacomo, Vitali, Giordano, Colombo, Sergio, Guazzarotti, Giorgia, Lembo, Rosalba, Maimeri, Nicolò, Faustini, Carolina, Pennella, Renato, Mushtaq, Junaid, Landoni, Giovanni, Scandroglio, Anna Mara, Dagna, Lorenzo, and De Cobelli, Francesco

Published
2021
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16. Post-exposure Lopinavir-Ritonavir Prophylaxis versus Surveillance for Individuals Exposed to SARS-CoV-2: The COPEP Pragmatic Open-Label, Cluster Randomized Trial

Author

Labhardt, Niklaus D, Smit, Mikaela, Petignat, Ianis, Perneger, Thomas, Marinosci, Annalisa, Ustero, Pilar, Diniz Ribeiro, Maria Pia, Ragozzino, Silvio, Nicoletti, Giovanni Jacopo, Faré, Pietro Benedetto, Andrey, Diego O, Jacquerioz, Frederique, Lebowitz, Dan, Agoritsas, Thomas, Meyer, Benjamin, Spechbach, Hervé, Salamun, Julien, Guessous, Idris, Chappuis, François, Kaiser, Laurent, Decosterd, Laurent Arthur, Grinsztejn, Beatriz, Bernasconi, Enos, Cardoso, Sandra Wagner, Calmy, Alexandra, and Team, for the COPEP Study

Published
2021
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19. Costs and acceptability of simplified monitoring in HIV-suppressed patients switching to dual therapy: the SIMPL’HIV open-label, factorial randomised controlled trial

Author

Marinosci, Annalisa; https://orcid.org/0000-0002-8054-0044, Sculier, Delphine; https://orcid.org/0000-0002-6741-9813, Wandeler, Gilles; https://orcid.org/0000-0002-5278-8763, Yerly, Sabine; https://orcid.org/0000-0003-1668-696X, Stoeckle, Marcel; https://orcid.org/0000-0002-0088-5078, Bernasconi, Enos; https://orcid.org/0000-0002-9724-8373, Braun, Dominique L; https://orcid.org/0000-0003-4036-1030, Vernazza, Pietro; https://orcid.org/0000-0002-6849-6941, Cavassini, Matthias; https://orcid.org/0000-0003-0933-7833, Buzzi, Marta, Metzner, Karin J; https://orcid.org/0000-0003-4862-1503, Decosterd, Laurent, Günthard, Huldrych F; https://orcid.org/0000-0002-1142-6723, Schmid, Patrick, Limacher, Andreas; https://orcid.org/0000-0002-9094-9476, Branca, Mattia; https://orcid.org/0000-0002-8063-7882, Calmy, Alexandra; https://orcid.org/0000-0002-1137-6826, Marinosci, Annalisa; https://orcid.org/0000-0002-8054-0044, Sculier, Delphine; https://orcid.org/0000-0002-6741-9813, Wandeler, Gilles; https://orcid.org/0000-0002-5278-8763, Yerly, Sabine; https://orcid.org/0000-0003-1668-696X, Stoeckle, Marcel; https://orcid.org/0000-0002-0088-5078, Bernasconi, Enos; https://orcid.org/0000-0002-9724-8373, Braun, Dominique L; https://orcid.org/0000-0003-4036-1030, Vernazza, Pietro; https://orcid.org/0000-0002-6849-6941, Cavassini, Matthias; https://orcid.org/0000-0003-0933-7833, Buzzi, Marta, Metzner, Karin J; https://orcid.org/0000-0003-4862-1503, Decosterd, Laurent, Günthard, Huldrych F; https://orcid.org/0000-0002-1142-6723, Schmid, Patrick, Limacher, Andreas; https://orcid.org/0000-0002-9094-9476, Branca, Mattia; https://orcid.org/0000-0002-8063-7882, and Calmy, Alexandra; https://orcid.org/0000-0002-1137-6826

Abstract

BACKGROUND: Clinical and laboratory monitoring of patients on antiretroviral therapy is an integral part of HIV care and determines whether treatment needs enhanced adherence or modification of the drug regimen. However, different monitoring and treatment strategies carry different costs and health consequences. MATERIALS AND METHODS: The SIMPL’HIV study was a randomised trial that assessed the non-inferiority of dual maintenance therapy. The co-primary outcome was a comparison of costs over 48 weeks of dual therapy with standard antiretroviral therapy and the costs associated with a simplified HIV care approach (patient-centred monitoring [PCM]) versus standard, tri-monthly routine monitoring. Costs included outpatient medical consultations (HIV/non-HIV consultations), non-medical consultations, antiretroviral therapy, laboratory tests and hospitalisation costs. PCM participants had restricted immunological and blood safety monitoring at weeks 0 and 48, and they were offered the choice to complete their remaining study visits via a telephone call, have medications delivered to a specified address, and to have blood tests performed at a location of their choice. We analysed the costs of both strategies using invoices for medical consultations issued by the hospital where the patient was followed, as well as those obtained from health insurance companies. Secondary outcomes included differences between monitoring arms for renal function, lipids and glucose values, and weight over 48 weeks. Patient satisfaction with treatment and monitoring was also assessed using visual analogue scales. RESULTS: Of 93 participants randomised to dolutegravir plus emtricitabine and 94 individuals to combination antiretroviral therapy (median nadir CD4 count, 246 cells/mm3; median age, 48 years; female, 17%),patient-centred monitoring generated no substantial reductions or increases in total costs (US$ –421 per year [95% CI –2292 to 1451]; p = 0.658). However, dual therapy was significa

Published
2024

20. Role of the HIV-1 Reservoir to Maintain Viral Suppression in a Simplified Strategy for the Long-Term Management of HIV-1 Infection (The SIMPL’HIV Trial)

Author

Mattia Branca, Annalisa Marinosci, Delphine Sculier, Gilles Wandeler, Sabine Yerly, Marcel Stoeckle, Enos Bernasconi, Dominique L. Braun, Kathrin Neumann, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Laurent A. Decosterd, Patrick Schmid, Andreas Limacher, Huldrych F. Günthard, Karin J. Metzner, and Alexandra Calmy

Subjects
HIV-1 reservoir, dolutegravir+emtricitabine, dual therapy, cART, HIV-1 RNA, Microbiology, QR1-502
Abstract

HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simplified maintenance antiretroviral therapy in chronically HIV-1 infected patients. In the SIMPL’HIV trial, HIV-1 DNA was quantified in peripheral blood mononuclear cells obtained at baseline and week 48 to investigate changes over time and evidence of a predictive relationship to maintain HIV-1 RNA

Published
2022
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21. Land consumption in Italy

Author

Andrea Strollo, Daniela Smiraglia, Roberta Bruno, Francesca Assennato, Luca Congedo, Paolo De Fioravante, Chiara Giuliani, Ines Marinosci, Nicola Riitano, and Michele Munafò

Subjects
copernicus, land cover, sentinel, map updating, urban growth, photointerpretation, Maps, G3180-9980
Abstract

This paper illustrates a land consumption map for Italy (year 2017) at a scale 1:1,300,000, and the assessment of its changes (2012–2017). We define land consumption as the replacement of a non-artificial land cover to an artificial land cover, both permanent and no-permanent. The maps are a 10 m spatial resolution raster, produced by photointerpretation of very high resolution images and semiautomatic classification of high resolution remote sensing images. An overall accuracy of 97.7% for the map of 2012 and of 99.66% for the map of 2017 was obtained. The results suggest that the method proposed is appropriate to detect land consumption, both for the urban densification and for the sprawling phenomena, from national to local level. Furthermore, because of the high spatial resolution and the classification scheme adopted, it is suitable for an effective monitoring system, compared to other existing classification systems or monitoring programs.

Published
2020
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27. Homogeneous geodesics of non-unimodular Lorentzian Lie groups and naturally reductive Lorentzian spaces in dimension three

Author

Calvaruso, Giovanni and Marinosci, Rosa Anna

Subjects
Mathematics - Differential Geometry, 53C20,53C22, 53C30
Abstract

We determine, for all three-dimensional non-unimodular Lie groups equipped with a Lorentzian metric, the set of homogeneous geodesics through a point. Together with the results of [C] and [CM2], this leads to the full classification of three-dimensional Lorentzian g.o. spaces and naturally reductive spaces.

Published
2008

28. Viral Infections and Cutaneous Drug-Related Eruptions

Author

Eleonora Anci, Camille Braun, Annalisa Marinosci, Frédérique Rodieux, Elise Midun, Maria-Jose Torres, and Jean-Christoph Caubet

Subjects
drug, hypersensitivity, allergy, virus, mechanism, Therapeutics. Pharmacology, RM1-950
Abstract

In the general population, up to 10% of children treated by antibiotics have cutaneous adverse drug reaction, but allergy is confirmed in less than 20% of patients. Most of the non-allergic reactions are probably due to virus, such as enterovirus acute infection or Ebstein-Barr Virus (EBV) acute infection or reactivation. Especially in children, viruses have the propensity to induce skin lesions (maculopapular rash, urticaria) due to their skin infiltration or immunologic response. In drug-related skin eruptions, a virus can participate by activating an immune predisposition. The culprit antibiotic is then the trigger for reacting. Even in severe drug-induced reactions, such as Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, viruses take part in immune phenomena, especially herpes viruses. Understanding the mechanisms of both virus- and drug-induced skin reaction is important to develop our clinical reflection and give an adaptive care to the patient. Our aim is to review current knowledge on the different aspects and potential roles of viruses in the different type of drug hypersensitivity reactions (DHR). Although major advances have been made those past year, further studies are needed for a better understanding of the link between viruses and DHR, to improve management of those patients.

Published
2021
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30. Immunodepression COVID-19-related as a promoting factor for severe Pseudomonas sepsis in an infant with not respiratory symptoms

Author

Letizia Zenzeri, Antonietta Giannattasio, Geremia Zito Marinosci, Eduardo Ponticiello, Margherita Raffaella Iodice, Maria Erennia Vitullo, and Vincenzo Tipo

Subjects
COVID-19, children, sepsis, diarrhea, fever, Medicine (General), R5-920
Abstract

The outbreak of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 is a reason of concern worldwide. While a high proportion of adult patients have been severely ill, requiring intensive care assistance and mechanical ventilation, pediatric patients seem to have a less invasive clinical expression of the disease. Reasons for a milder disease in children compared to that seen in adults are yet to be elucidated. Nonetheless, severe and fatal cases have been reported in children and are expected to continue to increase with the growing community transmission and overall current disease prevalence. We report the first case of an infant with a very mild not-respiratory COVID- 19 infection and a concomitant invasive bacterial sepsis.

Published
2021
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32. Land degradation assessment for sustainable soil management

Author

Francesca Assennato, Marco Di Leginio, Marco d'Antona, Ines Marinosci, Luca Congedo, Nicola Riitano, Anna Luise, and Michele Munafò

Subjects
Land degradation, land consumption, soil functions, ecosystem services, productivity., Agriculture, Plant culture, SB1-1110
Abstract

Desertification is a complex phenomenon defined as the extreme degree of land degradation induced by human activities and climatic conditions. Climate change is accelerating and widening these areas. Previews analysis and studies assessed the vulnerability to desertification in Italy at national and regional level through a methodological approach based on integrating climate, soil, vegetation, and socio-economic data (ESA). The studies carried out by ISPRA aim to provide an update of the of land degradation assessment in Italy, based on Trends.Earth methodology and of the three UN-SDGs sub-indicators on Target 15.3.1 (land use/land cover, land productivity and soil organic carbon above and below ground status and trends), together with additional dimensions of land degradation considered crucial for national land characters. Final assessment of the percentage of degraded land is around 36% of national area. This exercise demonstrates the importance to consider a larger number of data and include information on other factors, such as climate, physical, chemical data. This integrated approach to the assessment of land degradation will allow to describe also of the loss of related ecosystem services. Highlights - Assessment and mapping of land degradation in Italy, toward an improvement of SDG Target 15.3 indicator. - Trends.Earth methodology integrated with additional data and information, in order to map ecosystem conditions and related ecosystem services provision. - Focus on land cover change as Italy main degradation factor. - Analysis with disaggregated results is provided for a deeper understanding of the specific contribution of the sub-indicators at the local level. - Improving sustainable land management by integrating land degradation prevention.

Published
2020
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35. Efficacy of pragmatic same-day ring prophylaxis for adult individuals exposed to SARS-CoV-2 in Switzerland (COPEP): protocol of an open-label cluster randomised trial

Author

Thomas Perneger, Manuel Battegay, Mikaela Smit, Alexandra Calmy, Annalisa Marinosci, Giovanni Jacopo Nicoletti, Silvio Ragozzino, Diego O Andrey, Marcel Stoeckle, Dan Lebowitz, Benjamin Meyer, Moritz Back, Carla Schaubhut, Simon Fuchs, Laurent Decosterd, and Niklaus D Labhardt

Subjects
Medicine
Abstract

Introduction Lopinavir/ritonavir (LPV/r) has been proposed as repurposed drugs for pre-exposure and postexposure prophylaxis as well as therapy of COVID-19. Coronavirus postexposure prophylaxis (COPEP) trial aims at assessing their efficacy as postexposure ring-prophylaxis among adults exposed to SARS-CoV-2.Methods and analysis COPEP is a two-arm open-label cluster-randomised trial conducted in three cantons of Switzerland. Asymptomatic contacts (≥16 years) of individuals diagnosed with COVID-19 will be randomised (2:1) to either LPV/r (400 mg/100 mg two times per day) for 5 days, or a standard of care arm (no treatment). Asymptomatic individuals may be either SARS-CoV-2 positive or negative. Contacts living in the single household will form a cluster and will be randomised into the same arm. All participants will be followed-up for 21 days and undergo daily monitoring for COVID-19 symptoms. The primary endpoint is 21-day incidence of laboratory-confirmed COVID-19 with ≥1 compatible symptom, analysed in an intention-to-treat (ITT) analysis. The secondary endpoints include the 21-day incidence of COVID-19 as well as SARS-CoV-2 infection in a modified ITT analysis, excluding participants who had a positive SARS-CoV-2 RT-PCR from oropharyngeal swab and/or a positive SARS-CoV-2 IgG serology at baseline. Assuming a 21-day incidence for COVID-19 of 20% among contacts without postexposure chemoprophylaxis, to detect a relative risk reduction of 60% (ie, translating in an absolute reduction from 20% to 8%), with a power of 80%, an alpha of 5%. Accounting for design effect of cluster design of circa 1.1, we plan to enrol 200 participants to the LPV/r arm and 100 to the standard of care arm, 300 participants in total.Ethics and dissemination Ethics approval has been granted by the Commission Cantonale d’Ethique de la Recherche, Ethikkommission Nordwest- und Zentralschweiz and Comitato Etico Cantonale (ref 2020-00864) and Swissmedic (2020DR3056). Results from this trial will be disseminated via journal articles and presentations at national and international conferences.Trial registration number Clinicaltrials.gov Registry (NCT04364022); Swiss National Clinical Trial Portal Registry (SNCTP 000003732).Registered report identifier CCER 2020-0864.

Published
2020
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36. Efficacy and safety of dolutegravir plus emtricitabine versus standard ART for the maintenance of HIV-1 suppression: 48-week results of the factorial, randomized, non-inferiority SIMPL'HIV trial.

Author

Delphine Sculier, Gilles Wandeler, Sabine Yerly, Annalisa Marinosci, Marcel Stoeckle, Enos Bernasconi, Dominique L Braun, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Karin J Metzner, Laurent A Decosterd, Huldrych F Günthard, Patrick Schmid, Andreas Limacher, Matthias Egger, Alexandra Calmy, and Swiss HIV Cohort Study (SHCS)

Subjects
Medicine
Abstract

BackgroundDolutegravir (DTG)-based dual therapy is becoming a new paradigm for both the initiation and maintenance of HIV treatment. The SIMPL'HIV study investigated the outcomes of virologically suppressed patients on standard combination antiretroviral therapy (cART) switching to DTG + emtricitabine (FTC). We present the 48-week efficacy and safety data on DTG + FTC versus cART.Methods and findingsSIMPL'HIV was a multicenter, open-label, non-inferiority randomized trial with a factorial design among treatment-experienced people with HIV in Switzerland. Participants were enrolled between 12 May 2017 and 30 May 2018. Patients virologically suppressed for at least 24 weeks on standard cART were randomized 1:1 to switching to DTG + FTC or to continuing cART, and 1:1 to simplified patient-centered monitoring versus standard monitoring. The primary endpoint was the proportion of patients virologically suppressed with ConclusionsIn this study, DTG + FTC as maintenance therapy was non-inferior to cART in terms of efficacy, with a similar safety profile and a greater improvement in quality of life, thus expanding the offer of 2-drug simplification options among virologically suppressed individuals.Trial registrationClinicalTrials.gov NCT03160105.

Published
2020
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37. Efficacy and safety of exogenous surfactant therapy in patients under 12 months of age invasively ventilated for severe bronchiolitis (SURFABRON): protocol for a multicentre, randomised, double-blind, controlled, non-profit trial

Author

Marco Binotti, Giulia Genoni, Giorgio Conti, Andrea Michele Wolfler, Silvia Carlassara, Immacolata Rulli, Andrea Moscatelli, Camilla Micalizzi, Fabio Savron, Raffaella Sagredini, Fabio Caramelli, Monica Fae, Andrea Pettenazzo, Valentina Stritoni, Luigia D’Amato, Geremia Zito Marinosci, Edoardo Calderini, Stefano Scalia Catenacci, Alberto Berardi, Francesco Torcetta, Ezio Bonanomi, Daniele Bonacina, Giorgio Ivani, and Pierantonio Santuz

Subjects
Medicine
Abstract

Introduction Some evidence indicates that exogenous surfactant therapy may be effective in infants with acute viral bronchiolitis, even though more confirmatory data are needed. To date, no large multicentre trials have evaluated the effectiveness and safety of exogenous surfactant in severe cases of bronchiolitis requiring invasive mechanical ventilation (IMV).Methods and analysis This is a multicentre randomised, placebo-controlled, double-blind study, performed in 19 Italian paediatric intensive care units (PICUs). Eligible participants are infants under the age of 12 months hospitalised in a PICU, suffering from severe acute hypoxaemic bronchiolitis, requiring IMV. We adopted a more restrictive definition of bronchiolitis, including only infants below 12 months of age, to maintain the population as much homogeneous as possible. The primary outcome is to evaluate whether exogenous surfactant therapy (Curosurf, Chiesi Pharmaceuticals, Italy) is effective compared with placebo (air) in reducing the duration of IMV in the first 14 days of hospitalisation, in infants suffering from acute hypoxaemic viral bronchiolitis. Secondary outcomes are duration of non-invasive mechanical ventilation in the post-extubation phase, number of cases requiring new intubation after previous extubation within 14 days from randomisation, PICU and hospital length of stay (LOS), duration of oxygen dependency, effects on oxygenation and ventilatory parameters during invasive mechanical respiratory support, need for repeating treatment within 24 hours of first treatment, use of other interventions (eg, high-frequency oscillatory ventilation, nitric oxide, extracorporeal membrane oxygenation), mortality within the first 14 days of PICU stay and before hospital discharge, side effects and serious adverse events.Ethics and dissemination The trial design and protocol have received approval by the Italian National Agency for Drugs (AIFA) and by the Regional Ethical Committee of Verona University Hospital (1494CESC). Findings will be disseminated through publication in peer-reviewed journals, conference/meeting presentations and media.Trial registration number Clinicaltrials.gov, issue date 22 May 2019. NCT03959384.

Published
2020
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38. High Resolution Land Cover Integrating Copernicus Products: A 2012–2020 Map of Italy

Author

Paolo De Fioravante, Andrea Strollo, Francesca Assennato, Ines Marinosci, Luca Congedo, and Michele Munafò

Subjects
land cover, Copernicus, land monitoring, ecosystem services, CORINE land cover, carbon storage capacity, Agriculture
Abstract

The study involved an in-depth analysis of the main land cover and land use data available nationwide for the Italian territory, in order to produce a reliable cartography for the evaluation of ecosystem services. In detail, data from the land monitoring service of the Copernicus Programme were taken into consideration, while at national level the National Land Consumption Map and some regional land cover and land use maps were analysed. The classification systems were standardized with respect to the European specifications of the EAGLE Group and the data were integrated to produce a land cover map in raster format with a spatial resolution of 10 m. The map was validated and compared with the CORINE Land Cover, showing a significant geometric and thematic improvement, useful for a more detailed and reliable evaluation of ecosystem services. In detail, the map was used to estimate the variation in carbon storage capacity in Italy for the period 2012–2020, linked to the increase in land consumption

Published
2021
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40. Direct observation of the fracture behavior of the polyether ketone ketone (PEKK) spherulites.

Author

Marinosci, Vanessa, Chen, Kuan, Helthuis, Nick G. J., Grouve, Wouter J. B., de Vries, Erik G., Bao, Ningzhong, Akkerman, Remko, de Rooij, Matthijn B., and Chu, Liangyong

Subjects
KETONES, ATOMIC force microscopy, CRYSTALLINE polymers, DISCONTINUOUS precipitation, MATERIAL plasticity, POLYETHERS
Abstract

This article reports the direct observation of the fracture of individual poly‐ether‐ketone‐ketone (PEKK) spherulites. A single layer of PEKK spherulites was obtained by bonding a PEKK film in‐between two sandblasted Ti alloy plates using an autoclave. The crack of an individual PEKK spherulite was achieved by opening the Ti/PEKK/Ti sandwich using a double cantilever beam test. The fracture morphology of the PEKK spherulite was characterized using scanning electron microscopy and atomic force microscopy. It was found that under tensile stress the crack of the individual spherulite propagates along the middle plane and crosses the nucleation core. This is due to the symmetric radial structure of the spherulite. Moreover, it was found that the fracture surface morphology at the core of the spherulite is strongly influenced by the local crystalline structure, which is anisotropic and determined by the initial nucleation growth direction. As a result, the area fraction experiencing plastic deformation during the fracture of PEKK spherulites at different orientations may vary by an order of 10. Our results show the important role of the initial nucleation growth direction on the mechanical properties of the polymer crystals and may provide a new approach to the design of high‐performance polymer materials with tailored crystalline structures. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Two-year multidisciplinary follow-up of COVID-19 patients requiring invasive and noninvasive respiratory support.

Author

TRESOLDI, Moreno, ZANGRILLO, Alberto, BELLETTI, Alessandro, RAMIREZ, Giuseppe A., BOZZOLO, Enrica, GUZZO, Francesca, MARINOSCI, Alessandro, FOMINSKIY, Evgeny V., DA PRAT, Valentina, MARMIERE, Marilena, PALUMBO, Diego, DEL PRETE, Lidia, D’AMICO, Filippo, BELLINO, Chiara, MORANDO, Deodata, SARACINO, Marco, ORTALDA, Alessandro, CASTELLI, Elena, ROCCHI, Margherita, and BAIARDO REDAELLI, Martina

Published
2023
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42. Congenital syphilis in the twenty-first century: an area-based study

Author

Serena Salomè, Maria Donata Cambriglia, Sara Maria Scarano, Eleonora Capone, Ivy Betts, Daniela Pacella, Matilde Sansone, Laura Letizia Mazzarelli, Andrea Lo Vecchio, Giusy Ranucci, Geremia Zito Marinosci, Letizia Capasso, Paola Salvatore, Francesco Raimondi, Salome, Serena, Cambriglia, Maria Donata, Scarano, Sara Maria, Capone, Eleonora, Betts, Ivy, Pacella, Daniela, Sansone, Matilde, Mazzarelli, Laura Letizia, Lo Vecchio, Andrea, Ranucci, Giusy, Marinosci, Geremia Zito, Capasso, Letizia, Salvatore, Paola, and Raimondi, Francesco

Subjects
Surveillance, Pediatrics, Perinatology and Child Health, Maternal syphili, Syphilis epidemiology, Congenital syphili
Abstract

The resurgence of syphilis and subsequent risk for newborns has been described worldwide; however, European data on this congenital infection is lacking. We report the activity of a multidisciplinary specialized unit assisting a large area in the Southern Italy. A retrospective cohort study has been conducted at the Perinatal and Pediatric Infectious Diseases Units of the Federico II University of Naples, enrolling all newborns and children referred from January 2010 to June 2022 exposed to Treponema pallidum in utero and/or congenitally infected. A total of 323 patients were included in the analysis. Twenty (6.2%) received a diagnosis of confirmed congenital syphilis (CS) and one died. Fifteen CS cases had typical clinical features. Since 2017, the number of referred neonates tripled while the rate of late maternal diagnoses did not significantly differ. When compared with mothers of exposed infants, mothers of CS cases were younger (25 ± 7.2 vs 29.9 ± 6 years, p = 0.041), had less previous pregnancies (0.64 vs 1.11, p = 0.044), and received a diagnosis of syphilis at a later stage of pregnancy (86% vs 20%, from third trimester or later on; p p Conclusion: CS has still a significant impact. Prevention should be implemented towards specific maternal risk profiles. A specialized unit is the preferable model to improve surveillance and healthcare for this neglected population. What is Known:• The resurgence of syphilis and subsequent risk for newborns has been described worldwide.• European data on this congenital infection is lacking. What is New:• Congenital syphilis has a significant impact still in Europe and prevention should be implemented towards specific maternal risk profiles. • A specialized unit is the preferable model to improve surveillance and healthcare for this neglected population.

Published
2023

43. A radiological predictor for pneumomediastinum/pneumothorax in COVID-19 ARDS patients

Author

Diego Palumbo, Alberto Zangrillo, Alessandro Belletti, Giorgia Guazzarotti, Maria Rosa Calvi, Francesca Guzzo, Renato Pennella, Giacomo Monti, Chiara Gritti, Marilena Marmiere, Margherita Rocchi, Sergio Colombo, Davide Valsecchi, Anna Mara Scandroglio, Lorenzo Dagna, Patrizia Rovere-Querini, Moreno Tresoldi, Giovanni Landoni, Francesco De Cobelli, Carolina Faustini, Nicolò Maimeri, Rosalba Lembo, Giuseppe Di Lucca, Raffaella Scotti, Maria Vittoria Lavorato, Alessandro Tomellieri, Corrado Campochiaro, Fatemeh Darvizeh, Francesca Calabrese, Roberto Mapelli, Nicola Pasculli, Giovanni Borghi, Antonella Cipriani, Maria Grazia Calabrò, Martina Crivellari, Annalisa Franco, Marina Pieri, Evgeny V. Fominskiy, Stefano Franchini, Antonio Dell'Acqua, Alessandro Marinosci, Giordano Vitali, Nicola Compagnone, Palumbo, D., Zangrillo, A., Belletti, A., Guazzarotti, G., Calvi, M. R., Guzzo, F., Pennella, R., Monti, G., Gritti, C., Marmiere, M., Rocchi, M., Colombo, S., Valsecchi, D., Scandroglio, A. M., Dagna, L., Rovere-Querini, P., Tresoldi, M., Landoni, G., De Cobelli, F., Faustini, C., Maimeri, N., Lembo, R., Di Lucca, G., Scotti, R., Lavorato, M. V., Tomellieri, A., Campochiaro, C., Darvizeh, F., Calabrese, F., Mapelli, R., Pasculli, N., Borghi, G., Cipriani, A., Calabro, M. G., Crivellari, M., Franco, A., Pieri, M., Fominskiy, E. V., Franchini, S., Dell'Acqua, A., Marinosci, A., Vitali, G., and Compagnone, N.

Subjects
ARDS, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, LR, likelihood ratio, Pneumomediastinum, Acute respiratory distress, Critical Care and Intensive Care Medicine, Article, Mechanical ventilation, Humans, Medicine, ARDS, acute respiratory distress syndrome, Mediastinal Emphysema, COVID-19, coronavirus disease 2019, PMD, pneumomediastinum, Respiratory Distress Syndrome, Chest imaging, Acute respiratory distress syndrome, SARS-CoV-2, business.industry, Tomography, X-ray computed, Pneumothorax, COVID-19, medicine.disease, PPV, positive predictive value, PNX, pneumothorax, NPV, negative predictive value, Case-Control Studies, Radiological weapon, Radiology, business
Abstract

Purpose: To determine whether Macklin effect (a linear collection of air contiguous to the bronchovascular sheath) on baseline CT imaging is an accurate predictor for subsequent pneumomediastinum (PMD)/pneumothorax (PNX) development in invasively ventilated patients with COVID-19-related acute respiratory distress syndrome (ARDS). Materials and methods: This is an observational, case-control study. From a prospectively acquired database, all consecutive invasively ventilated COVID-19 ARDS patients who underwent at least one baseline chest CT scan during the study time period (February 25th, 2020–December 31st, 2020) were identified; those who had tracheal lesion or already had PMD/PNX at the time of the first available chest imaging were excluded. Results: 37/173 (21.4%) patients enrolled had PMD/PNX; specifically, 20 (11.5%) had PMD, 10 (5.8%) PNX, 7 (4%) both. 33/37 patients with subsequent PMD/PNX had Macklin effect on baseline CT (89.2%, true positives) 8.5 days [range, 1–18] before the first actual radiological evidence of PMD/PNX. Conversely, 6/136 patients without PMD/PNX (4.4%, false positives) demonstrated Macklin effect (p < 0.001). Macklin effect yielded a sensitivity of 89.2% (95% confidence interval [CI]: 74.6–96.9), a specificity of 95.6% (95% CI: 90.6–98.4), a positive predictive value (PV) of 84.5% (95% CI: 71.3–92.3), a negative PV of 97.1% (95% CI: 74.6–96.9) and an accuracy of 94.2% (95% CI: 89.6–97.2) in predicting PMD/PNX (AUC:0.924). Conclusions: Macklin effect accurately predicts, 8.5 days in advance, PMD/PNX development in COVID-19 ARDS patients.

Published
2021

45. Outcomes of noninvasive ventilation as the ceiling of treatment in patients with COVID-19

Author

Giuseppe A, Ramirez, Enrica P, Bozzolo, Agnese, Gobbi, Elena, Castelli, Clarissa, Centurioni, Mattia, DI Meo, Emanuel, Della Torre, Flavia, DI Scala, Anna, Morgillo, Alessandro, Marinosci, Martina, Miglio, Paolo, Scarpellini, Chiara, Tassan Din, Barbara, Castiglioni, Chiara, Oltolini, Marco, Ripa, Gaetano, DI Terlizzi, Valentina, DA Prat, Sarah, Damanti, Raffaella, Scotti, Giuseppe, DI Lucca, Martina, Baiardo Redaelli, Valentina P, Plumari, Elena, Moizo, Francesco, Carcó, Paolo, Silvani, Francesco, DE Cobelli, Giovanni, Landoni, Moreno, Tresoldi, Mona-Rita, Yacoub, Ramirez, Giuseppe A, Bozzolo, Enrica P, Gobbi, Agnese, Castelli, Elena, Centurioni, Clarissa, DI Meo, Mattia, Della Torre, Emanuel, DI Scala, Flavia, Morgillo, Anna, Marinosci, Alessandro, Miglio, Martina, Scarpellini, Paolo, Tassan Din, Chiara, Castiglioni, Barbara, Oltolini, Chiara, Ripa, Marco, DI Terlizzi, Gaetano, DA Prat, Valentina, Damanti, Sarah, Scotti, Raffaella, DI Lucca, Giuseppe, Baiardo Redaelli, Martina, Plumari, Valentina P, Moizo, Elena, Carcó, Francesco, Silvani, Paolo, DE Cobelli, Francesco, Landoni, Giovanni, and Tresoldi, Moreno

Subjects
Mechanical ventilation, ARDS, medicine.medical_specialty, business.industry, medicine.medical_treatment, Vital signs, General Medicine, Disease, medicine.disease, Heart failure, Cohort, Emergency medicine, medicine, Intubation, Continuous positive airway pressure, business
Abstract

Background: Non-invasive mechanical ventilation (NIV) is effective for symptom relief and respiratory support in patients with respiratory insufficiency, severe comorbidities and no indication to intubation. Experience with NIV as the ceiling of treatment in severely compromised novel coronavirus disease (COVID-19) patients is lacking. Methods: We evaluated 159 patients with COVID-19-related acute respiratory syndrome (ARDS), 38 of whom with NIV as the ceiling of treatment, admitted to an ordinary ward and treated with continuous positive airway pressure (CPAP) and respiratory physiotherapy. Treatment failure and death were correlated with clinical and laboratory parameters in the whole cohort and in patients with NIV as the ceiling of treatment. Results: Patients who had NIV as the ceiling of treatment were elderly, with a low BMI and a high burden of comorbidities, showed clinical and laboratory signs of multi-organ insufficiency on admission and of rapidly deteriorating vital signs during the first week of treatment. NIV failure occurred overall in 77 (48%) patients, and 27/38 patients with NIV as the ceiling of treatment died. Congestive heart failure, chronic benign haematological diseases and inability/refusal to receive respiratory physiotherapy were independently associated to NIV failure and mortality. Need for increased positive end-expiratory pressures and low platelets were associated with NIV failure. Death was associated to cerebrovascular disease, need for CPAP cycles longer than 12h and, in the subgroup of patients with NIV as the ceiling of treatment, was heralded by vital sign deterioration within 48 h. Conclusions: NIV and physiotherapy are a viable treatment option for patients with severe COVID-19 and severe comorbidities.

Published
2022

50. Improving the accessibility of API documentation for non-technical users

Author

Marinosci, Gabriele, Shchadrynski, Ratmir, Marinosci, Gabriele, and Shchadrynski, Ratmir

Abstract

Software documentation is one of the most important aspects of the software development process, as it allows the transfer of knowledge between individuals, regardless of their background and their technical knowledge. In particular, Application Programming Interfaces provide the basic structure for the communication and integration between different software systems. Therefore, providing solid API documentation is fundamental for the software development process as it represents one of the main learning tools for developers trying to learn new technologies. While researchers have studied the fundamentals of good API documentation design for over twenty years, most studies only focused on the point of view of developers. However, with the rising amount of companies offering Software-as-a-Service products, it has also become important to produce documentation that is accessible to people with limited technical knowledge, i.e. customer representatives. In order to fill this research gap, a case study was conducted in collaboration with a software company. By using a design science approach, this project focused on creating an API playground environment where users could interact with various APIs offered by the company. The results were evaluated through a questionnaire for user feedback and with an interview conducted with developers from the company. While the outcome of the evaluation was positive, the limited scope of the project prevented some important aspects of API documentation such as navigation from being thoroughly examined, therefore more extensive research is needed in the future.

Published
2023

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