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333 results on '"Marino, I. R."'

30. Baboon-to-human liver transplantation

Author

Starzl, T. E., Fung, J., Tzakis, A., Todo, S., Demetris, A. J., Marino, I. R., Doyle, H., Zeevi, A., Warty, V., Michaels, M., Kusne, S., Rudert, W. A., and Trucco, M.

Published
1993

33. Conversion from tacrolimus to cyclosporine--a based immunosuppression following liver transplantation

Author

Doria, C., Jain, A. K., Scott, V. L., Gruttadauria, S., Marino, I. R., Doyle, H. R., and John Fung

Subjects
Adult, Graft Rejection, Male, Gastrointestinal Diseases, Middle Aged, Hematologic Diseases, Tacrolimus, Liver Transplantation, Treatment Outcome, Retreatment, Cyclosporine, Humans, Female, Nervous System Diseases, Immunosuppressive Agents, Aged, Retrospective Studies
Abstract

We examined the frequency, reasons and outcome after conversion from Tacrolimus to Cyclosporine A. From August 1989 to December 1992, 1000 consecutive liver transplantation patients were studied, which included 834 adults (age18 yr.) and 166 children with mean follow-up of 77 months (range 56 to 96). A prospectively populated electronic database was queried to identify patients that underwent conversion, the clinical indication and outcomes. Thirty-seven out of 834 adult recipients (4.43%), mean age of 48.4+/-12.9 years, 19 male (51.35%) and 18 females (48.64%) required conversion from Tacrolimus to Cyclosporine A baseline immunosuppressive therapy. No pediatric patient required conversion. The mean time interval from liver transplantation to Cyclosporine A conversion was 443.45+/-441.44 days (range 22 to 1641). The clinical indications for conversion included: 20 neurological (54%), 6 gastrointestinal (16%), 5 hematological (14%), and 6 other (16%) scenarios. Seven of the 37 patients (18.9%) died. The causes of death were multi-organ failure (2), sepsis (2), pancreatitis (1), hepatic failure due to relapse of ethanol abuse (1), and unknown cause (1). Nine out of 37 patients (24.32%) had to be reconverted to Tacrolimus (mean 282.22+/-499.79 days; range 15 to 1583 day with a median of 135) after institution of Cyclosporine A; none showed recurrence of the original symptoms. The reasons for these re-conversions were acute cellular rejection (44%, n=4), chronic rejection (11%, n=1), increased hepatic enzymes (33%, n=3) and progressively worsening neurological symptoms (11%, n=1). The frequency of conversion from Tacrolimus to Cyclosporine A was 4.43%. Conversion is safe and efficacious if done in a controlled setting. Additionally, re-conversion to Tacrolimus for lack of efficacy of Cyclosporine A did not appear to be associated with a recurrence of the condition that caused the initial switch.

Published
2005

41. The hepatic artery in liver transplantation and surgery: vascular anomalies in 701 cases

Author

Gruttadauria, Salvatore Giovanni, Scotti Foglieni, C., Doriac, Luca, A., Lauro, A., and Marino, I. R. .

Subjects
Male, Hepatic Artery, Hepatic artery anomalies, Humans, Female, liver surgery, liver transplantation, female, hepatic artery, humans, male, retrospective studies, Liver Transplantation, Retrospective Studies
Abstract

The purpose of this study is to report the variations in hepatic arterial supply of a mixed population of organ donors in which the anatomy was individually examined during the bench surgery, and patients who underwent a selective angiogram of the celiac axis and superior mesenteric artery. We reviewed the donor forms and/or angiograms of 701 patients. The donor forms were completed personally by one of the authors, while all the radiology images were obtained through studies performed by one single radiologist. The arterial anatomy was anomalous in 296 out of 701 cases with an overall incidence of hepatic artery anomalies of 42.22%. In this paper we describe previously unreported arterial anomalies of the hepatic artery, collecting the second largest series of hepatic artery anatomical variations of the English literature. This anatomical update can be useful for transplant and general surgeons, as well as vascular radiologists.

Published
2001

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