223 results on '"Marini, Sandro"'
Search Results
2. Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project
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Hu, Yao, Haessler, Jeffrey W, Manansala, Regina, Wiggins, Kerri L, Moscati, Arden, Beiser, Alexa, Heard-Costa, Nancy L, Sarnowski, Chloe, Raffield, Laura M, Chung, Jaeyoon, Marini, Sandro, Anderson, Christopher D, Rosand, Jonathan, Xu, Huichun, Sun, Xiao, Kelly, Tanika N, Wong, Quenna, Lange, Leslie A, Rotter, Jerome I, Correa, Adolfo, Vasan, Ramachandran S, Seshadri, Sudha, Rich, Stephen S, Do, Ron, Loos, Ruth JF, Longstreth, William T, Bis, Joshua C, Psaty, Bruce M, Tirschwell, David L, Assimes, Themistocles L, Silver, Brian, Liu, Simin, Jackson, Rebecca, Wassertheil-Smoller, Sylvia, Mitchell, Braxton D, Fornage, Myriam, Auer, Paul L, Reiner, Alex P, Kooperberg, Charles, and Group, the NHLBI Trans-Omics for Precision Medicine Consortium the Trans-Omics for Precision Medicine Stroke Working
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Epidemiology ,Health Sciences ,Human Genome ,Neurosciences ,Brain Disorders ,Stroke ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Female ,Genetic Loci ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Male ,Middle Aged ,Polymorphism ,Single Nucleotide ,Precision Medicine ,Racial Groups ,Whole Genome Sequencing ,atherosclerosis ,blood pressure ,cause of death ,embolic stroke ,sample size ,Trans-Omics for Precision Medicine (TOPMed) Stroke Working Group ,the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Neurology & Neurosurgery ,Clinical sciences ,Allied health and rehabilitation science - Abstract
Background and purposeStroke is the leading cause of death and long-term disability worldwide. Previous genome-wide association studies identified 51 loci associated with stroke (mostly ischemic) and its subtypes among predominantly European populations. Using whole-genome sequencing in ancestrally diverse populations from the Trans-Omics for Precision Medicine (TOPMed) Program, we aimed to identify novel variants, especially low-frequency or ancestry-specific variants, associated with all stroke, ischemic stroke and its subtypes (large artery, cardioembolic, and small vessel), and hemorrhagic stroke and its subtypes (intracerebral and subarachnoid).MethodsWhole-genome sequencing data were available for 6833 stroke cases and 27 116 controls, including 22 315 European, 7877 Black, 2616 Hispanic/Latino, 850 Asian, 54 Native American, and 237 other ancestry participants. In TOPMed, we performed single variant association analysis examining 40 million common variants and aggregated association analysis focusing on rare variants. We also combined TOPMed European populations with over 28 000 additional European participants from the UK BioBank genome-wide array data through meta-analysis.ResultsIn the single variant association analysis in TOPMed, we identified one novel locus 13q33 for large artery at whole-genome-wide significance (P
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- 2022
3. A Brain Care Score for Dementia and Stroke: Data from the UK Biobank Cohort (P10-15.002)
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Singh, Sanjula, primary, Oreskovic, Tin, additional, Carr, Sinclair, additional, Papier, Keren, additional, Conroy, Megan, additional, Senff, Jasper, additional, Chemali, Zeina, additional, Gutierrez-Martinez, Leidys, additional, Parodi, Livia, additional, Mayerhofer, Ernst, additional, Marini, Sandro, additional, Nunley, Courtney, additional, Newhouse, Amy, additional, Ouyang, An, additional, Brouwers, Bart, additional, Westover, Brandon, additional, Rivier, Cyprien, additional, Falcone, Guido, additional, Howard, Virgina, additional, Howard, George, additional, Pikula, Aleksandra, additional, Ibrahim, Sarah, additional, Sheth, Kevin, additional, Yechoor, Nirupama, additional, Lazar, Ronald, additional, Anderson, Christopher, additional, Fricchione, Gregory, additional, Littlejohns, Thomas, additional, and Rosand, Jonathan, additional
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- 2024
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4. A Brain Care Score to Mitigate the Genetic Risk of Adverse Brain Health Outcomes (S16.010)
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Kimball, Tamara, primary, Mayerhofer, Ernst, additional, Senff, Jasper, additional, Marini, Sandro, additional, Rivier, Cyprien A., additional, Kourkoulis, Christina, additional, Oreskovic, Tin, additional, Carr, Sinclair, additional, Falcone, Guido, additional, Yechoor, Nirupama, additional, Rosand, Jonathan, additional, Singh, Sanjula, additional, Parodi, Livia, additional, and Anderson, Christopher, additional
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- 2024
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5. A Brain Care Score for Risk of Late-life Depression: Data from the UK Biobank Cohort (P10-15.001)
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Singh, Sanjula, primary, Rivier, Cyprien, additional, Oreskovic, Tin, additional, Carr, Sinclair, additional, Papier, Keren, additional, Chemali, Zeina, additional, Gutierrez-Martinez, Leidys, additional, Mallick, Akashleena, additional, Parodi, Livia, additional, Mayerhofer, Ernst, additional, Senff, Jasper, additional, Kourkoulis, Christina, additional, Marini, Sandro, additional, Clocchiatti-Tuozzo, Santiago, additional, Nunley, Courtney, additional, Newhouse, Amy, additional, Ouyang, An, additional, Westover, Brandon, additional, Lazar, Ronald, additional, Pikula, Aleksandra, additional, Ibrahim, Sarah, additional, Brouwers, Bart, additional, Howard, Virgina, additional, Howard, George, additional, Yechoor, Nirupama, additional, van Duijn, Cornelia, additional, Littlejohns, Thomas, additional, Sheth, Kevin, additional, Rosand, Jonathan, additional, Gricchione, Gregory, additional, Anderson, Christopher, additional, and Falcone, Guido, additional
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- 2024
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6. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons.
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Rivier, Cyprien A., Singh, Sanjula, Senff, Jasper, Tack, Reinier W., Marini, Sandro, Clocchiatti-Tuozzo, Santiago, Shufan Huo, Renedo, Daniela, Papier, Keren, Conroy, Megan, Littlejohns, Thomas J., Chemali, Zeina, Kourkoulis, Christina, Payabvash, Seyedmehdi, Newhouse, Amy, Westover, M. Brandon, Lazar, Ronald M., Pikula, Aleksandra, Ibrahim, Sarah, and Howard, Virginia J.
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- 2024
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7. Abstract WMP19: A Brain Care Score for Risk of Late-Life Depression: Data From the UK Biobank Cohort
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Singh, Sanjula D, primary, Rivier, Cyprien, additional, Oreskovic, Tin, additional, Carr, Sinclair, additional, Papier, Keren, additional, Chemali, Zeina, additional, Guiterrez-Martinez, Leidys, additional, Mallick, Akashleena, additional, Parodi, Livia, additional, Mayerhofer, Ernst, additional, Senff, Jasper, additional, Kourkoulis, Christina, additional, Marini, Sandro, additional, Clocchiatti-Tuozzo, Santiago, additional, Nunley, Courtney, additional, Newhouse, Amy, additional, Ouyang, An, additional, Westover, Michael B, additional, Tanzi, Rudolph, additional, Lazar, Ronald M, additional, Pikula, Aleksandra, additional, Ibrahim, Sarah, additional, Brouwers, H, additional, Howard, Virginia J, additional, Howard, George, additional, Yechoor, Nirupama, additional, van Duijn, Cornelia, additional, Littlejohns, Thomas, additional, Sheth, Kevin N, additional, Rosand, Jonathan, additional, Fricchione, Gregory, additional, Anderson, Christopher D, additional, and Falcone, Guido J, additional
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- 2024
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8. Abstract 37: The Brain Care Score and Neuroimaging Markers in Asymptomatic Individuals in the UK Biobank
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Rivier, Cyprien, primary, Singh, Sanjula D, additional, Senff, Jasper, additional, Marini, Sandro, additional, Oreskovic, Tin, additional, Carr, Sinclair, additional, Papier, Keren, additional, Conroy, Megan, additional, Chemali, Zeina, additional, Gutierrez, Leidys, additional, Mallick, Akashleena, additional, Parodi, Livia, additional, Mayerhofer, Ernst, additional, Kourkoulis, Christina, additional, Clocchiatti-Tuozzo, Santiago, additional, Nunley, Courtney, additional, Payabvash, Sam, additional, Newhouse, Amy, additional, Ouyang, An, additional, Lazar, Ronald M, additional, Westover, Michael B, additional, Pikula, Aleksandra, additional, Ibrahim, Sarah, additional, Brouwers, Bart, additional, Howard, Virginia J, additional, Howard, George, additional, Yechoor, Nirupama, additional, van Duijn, Cornelia, additional, Littlejohns, Thomas, additional, Tanzi, Rudolph, additional, Fricchione, Gregory, additional, Sheth, Kevin N, additional, Rosand, Jonathan, additional, Anderson, Christopher D, additional, and Falcone, Guido J, additional
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- 2024
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9. Abstract WMP18: A Brain Care Score for Dementia and Stroke: Data From the UK Biobank Cohort
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Singh, Sanjula D, primary, Oreskovic, Tin, additional, Carr, Sinclair, additional, Papier, Keren, additional, Conroy, Megan, additional, Senff, Jasper, additional, Chemali, Zeina, additional, Gutierrez-Martinez, Leidys, additional, Parodi, Livia, additional, Mayerhofer, Ernst, additional, Marini, Sandro, additional, Nunley, Courtney, additional, Kourkoulis, Christina, additional, Newhouse, Amy, additional, Ouyang, An, additional, Brouwers, H B, additional, Westover, Brandon, additional, Rivier, Cyprien, additional, Falcone, Guido J, additional, Howard, Virginia J, additional, Howard, George, additional, Sheth, Kevin N, additional, Yechoor, Nirupama, additional, Lazar, Ronald M, additional, Anderson, Christopher D, additional, Tanzi, Rudolph, additional, Fricchione, Gregory, additional, Littlejohns, Thomas, additional, and Rosand, Jonathan, additional
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- 2024
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10. Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies
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Traylor, Matthew, Persyn, Elodie, Tomppo, Liisa, Klasson, Sofia, Abedi, Vida, Bakker, Mark K, Torres, Nuria, Li, Linxin, Bell, Steven, Rutten-Jacobs, Loes, Tozer, Daniel J, Griessenauer, Christoph J, Zhang, Yanfei, Pedersen, Annie, Sharma, Pankaj, Jimenez-Conde, Jordi, Rundek, Tatjana, Grewal, Raji P, Lindgren, Arne, Meschia, James F, Salomaa, Veikko, Havulinna, Aki, Kourkoulis, Christina, Crawford, Katherine, Marini, Sandro, Mitchell, Braxton D, Kittner, Steven J, Rosand, Jonathan, Dichgans, Martin, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Zand, Ramin, Ruigrok, Ynte, Rost, Natalia, Lemmens, Robin, Rothwell, Peter M, Anderson, Christopher D, Wardlaw, Joanna, Lewis, Cathryn M, and Markus, Hugh S
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- 2021
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11. Longitudinal changes in MoCA performances in patients with mild cognitive impairment and small vessel disease. Results from the VMCI-Tuscany Study
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Salvadori, Emilia, Poggesi, Anna, Pracucci, Giovanni, Chiti, Alberto, Ciolli, Laura, Del Bene, Alessandra, Di Donato, Ilaria, Marini, Sandro, Nannucci, Serena, Orlandi, Giovanni, Pasi, Marco, Pescini, Francesca, Valenti, Raffaella, Federico, Antonio, Dotti, Maria Teresa, Bonuccelli, Ubaldo, Inzitari, Domenico, and Pantoni, Leonardo
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- 2021
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12. Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
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Marini, Sandro, Davis, Kathryn A., Soare, Thomas W., Zhu, Yiwen, Suderman, Matthew J., Simpkin, Andrew J., Smith, Andrew D.A.C., Wolf, Erika J., Relton, Caroline L., and Dunn, Erin C.
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- 2020
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13. Association Between Perihematomal Perfusion and Intracerebral Hemorrhage Outcome
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Morotti, Andrea, Busto, Giorgio, Bernardoni, Andrea, Marini, Sandro, Casetta, Ilaria, and Fainardi, Enrico
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- 2020
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14. Genetic overlap and causal inferences between kidney function and cerebrovascular disease
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Marini, Sandro, Georgakis, Marios K., Chung, Jaeyoon, Henry, Jonathan Q.A., Dichgans, Martin, Rosand, Jonathan, Malik, Rainer, and Anderson, Christopher D.
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- 2020
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15. Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage
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Pasi, Marco, Charidimou, Andreas, Boulouis, Gregoire, Fotiadis, Panagiotis, Morotti, Andrea, Xiong, Li, Marini, Sandro, Ayres, Alison, Frosch, Matthew P., Goldstein, Joshua N., Rosand, Jonathan, Gurol, M. Edip, Greenberg, Steven M., and Viswanathan, Anand
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- 2019
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16. Genetic considerations in cerebral small vessel diseases
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Bhagat, Riwaj, primary, Marini, Sandro, additional, and Romero, José R., additional
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- 2023
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17. The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort.
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Singh, Sanjula D., Oreskovic, Tin, Carr, Sinclair, Papier, Keren, Conroy, Megan, Senff, Jasper R., Chemali, Zeina, Gutierrez-Martinez, Leidys, Parodi, Livia, Mayerhofer, Ernst, Marini, Sandro, Nunley, Courtney, Newhouse, Amy, Ouyang, An, Brouwers, H. Bart, Westover, Brandon, Rivier, Cyprien, Falcone, Guido, Howard, Virginia, and Howard, George
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STROKE ,PREDICTIVE validity ,DEMENTIA ,DISEASE risk factors ,AGE groups - Abstract
Introduction: The 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes and lifestyle choices in order to sustainably reduce the risk of dementia and stroke. We aimed to assess the associations of the BCS with risk of incident dementia and stroke. Methods: The BCS was derived from the United Kingdom Biobank (UKB) baseline evaluation for participants aged 40–69 years, recruited between 2006–2010. Associations of BCS and risk of subsequent incident dementia and stroke were estimated using Cox proportional hazard regressions, adjusted for sex assigned at birth and stratified by age groups at baseline. Results: The BCS (median: 12; IQR:11–14) was derived for 398,990 UKB participants (mean age: 57; females: 54%). There were 5,354 incident cases of dementia and 7,259 incident cases of stroke recorded during a median follow-up of 12.5 years. A five-point higher BCS at baseline was associated with a 59% (95%CI: 40-72%) lower risk of dementia among participants aged <50. Among those aged 50– 59, the figure was 32% (95%CI: 20-42%) and 8% (95%CI: 2-14%) for those aged >59 years. A five-point higher BCS was associated with a 48% (95%CI: 39-56%) lower risk of stroke among participants aged <50, 52% (95%CI, 47-56%) among those aged 50–59, and 33% (95%CI, 29-37%) among those aged >59. Discussion: The BCS has clinically relevant and statistically significant associations with risk of dementia and stroke in approximately 0.4 million UK people. Future research includes investigating the feasibility, adaptability and implementation of the BCS for patients and providers worldwide. [ABSTRACT FROM AUTHOR]
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- 2023
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18. Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage
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Uniken Venema, Simone M., Marini, Sandro, Lena, Umme K., Morotti, Andrea, Jessel, Michael, Moomaw, Charles J., Kourkoulis, Christina, Testai, Fernando D., Kittner, Steven J., Brouwers, H. Bart, James, Michael L., Woo, Daniel, Anderson, Christopher D., and Rosand, Jonathan
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- 2019
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19. Men Experience Higher Risk of Pneumonia and Death After Intracerebral Hemorrhage
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Marini, Sandro, Morotti, Andrea, Lena, Umme K., Goldstein, Joshua N., Greenberg, Steven M., Rosand, Jonathan, and Anderson, Christopher D.
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- 2018
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20. Pleiotropy analysis between lobar intracerebral hemorrhage and CSF β-amyloid highlights new and established associations
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Marini, Sandro, primary, Chung, Jaeyoon, additional, Han, Xudong, additional, Sun, Xinyu, additional, Parodi, Livia, additional, Farrer, Lindsay A, additional, Rosand, Jonathan, additional, Romero, Jose Rafael, additional, and Anderson, Christopher D, additional
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- 2023
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21. Abstract TMP80: Sex Is Associated With Location, Severity And Outcome Of Intracerebral Hemorrhage: A Combined Analysis Of Four Landmark Studies
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Rivier, Cyprien, primary, Acosta, Julian, additional, Renedo, Daniela, additional, Marini, Sandro, additional, Magid-Bernstein, Jessica, additional, Rosand, Jonathan, additional, Hanley, Daniel F, additional, Ziai, Wendy C, additional, Mayer, Stephan, additional, Woo, Daniel, additional, Sansing, Lauren H, additional, Sheth, Kevin N, additional, Anderson, Christopher D, additional, and Falcone, Guido J, additional
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- 2023
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22. sj-docx-1-wso-10.1177_17474930231155816 – Supplemental material for Pleiotropy analysis between lobar intracerebral hemorrhage and CSF β-amyloid highlights new and established associations
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Marini, Sandro, Chung, Jaeyoon, Han, Xudong, Sun, Xinyu, Parodi, Livia, Farrer, Lindsay A, Rosand, Jonathan, Romero, Jose Rafael, and Anderson, Christopher D
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FOS: Clinical medicine ,Cardiology ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental material, sj-docx-1-wso-10.1177_17474930231155816 for Pleiotropy analysis between lobar intracerebral hemorrhage and CSF β-amyloid highlights new and established associations by Sandro Marini, Jaeyoon Chung, Xudong Han, Xinyu Sun, Livia Parodi, Lindsay A Farrer, Jonathan Rosand, Jose Rafael Romero and Christopher D Anderson in International Journal of Stroke
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- 2023
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23. 17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage
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Marini, Sandro, Devan, William J., Radmanesh, Farid, Miyares, Laura, Poterba, Timothy, Hansen, Björn M., Norrving, Bo, Jimenez-Conde, Jordi, Giralt-Steinhauer, Eva, Elosua, Roberto, Cuadrado-Godia, Elisa, Soriano, Carolina, Roquer, Jaume, Kourkoulis, Christina E., Ayres, Alison M., Schwab, Kristin, Tirschwell, David L., Selim, Magdy, Brown, Devin L., Silliman, Scott L., Worrall, Bradford B., Meschia, James F., Kidwell, Chelsea S., Montaner, Joan, Fernandez-Cadenas, Israel, Delgado, Pilar, Greenberg, Steven M., Lindgren, Arne, Matouk, Charles, Sheth, Kevin N., Woo, Daniel, Anderson, Christopher D., Rosand, Jonathan, and Falcone, Guido J.
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- 2018
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24. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
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Chauhan, Ganesh, Adams, Hieab H.H., Satizabal, Claudia L., Bis, Joshua C., Teumer, Alexander, Sargurupremraj, Muralidharan, Hofer, Edith, Trompet, Stella, Hilal, Saima, Smith, Albert Vernon, Jian, Xueqiu, Malik, Rainer, Traylor, Matthew, Pulit, Sara L., Amouyel, Philippe, Mazoyer, Bernard, Zhu, Yi-Cheng, Kaffashian, Sara, Schilling, Sabrina, Beecham, Gary W., Montine, Thomas J., Schellenberg, Gerard D., Kjartansson, Olafur, Guðnason, Vilmundur, Knopman, David S., Griswold, Michael E., Windham, B. Gwen, Gottesman, Rebecca F., Mosley, Thomas H., Schmidt, Reinhold, Saba, Yasaman, Schmidt, Helena, Takeuchi, Fumihiko, Yamaguchi, Shuhei, Nabika, Toru, Kato, Norihiro, Rajan, Kumar B., Aggarwal, Neelum T., De Jager, Philip L., Evans, Denis A., Psaty, Bruce M., Rotter, Jerome I., Rice, Kenneth, Lopez, Oscar L., Liao, Jiemin, Chen, Christopher, Cheng, Ching-Yu, Wong, Tien Y., Ikram, Mohammad K., van der Lee, Sven J., Amin, Najaf, Chouraki, Vincent, DeStefano, Anita L., Aparicio, Hugo J., Romero, Jose R., Maillard, Pauline, DeCarli, Charles, Wardlaw, Joanna M., Hernández, Maria del C. Valdés, Luciano, Michelle, Liewald, David, Deary, Ian J., Starr, John M., Bastin, Mark E., Muñoz Maniega, Susana, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, Uh, Hae-Won, Lemmens, Robin, Brodaty, Henry, Wright, Margaret J., Ames, David, Boncoraglio, Giorgio B., Hopewell, Jemma C., Beecham, Ashley H., Blanton, Susan H., Wright, Clinton B., Sacco, Ralph L., Wen, Wei, Thalamuthu, Anbupalam, Armstrong, Nicola J., Chong, Elizabeth, Schofield, Peter R., Kwok, John B., van der Grond, Jeroen, Stott, David J., Ford, Ian, Jukema, J. Wouter, Vernooij, Meike W., Hofman, Albert, Uitterlinden, André G., van der Lugt, Aad, Wittfeld, Katharina, Grabe, Hans J., Hosten, Norbert, von Sarnowski, Bettina, Völker, Uwe, Levi, Christopher, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie L.M., Rosand, Jonathan, Woo, Daniel, Cole, John W., Meschia, James F., Slowik, Agnieszka, Thijs, Vincent, Lindgren, Arne, Melander, Olle, Grewal, Raji P., Rundek, Tatjana, Rexrode, Kathy, Rothwell, Peter M., Arnett, Donna K., Jern, Christina, Johnson, Julie A., Benavente, Oscar R., Wasssertheil-Smoller, Sylvia, Lee, Jin-Moo, Wong, Quenna, Mitchell, Braxton D., Rich, Stephen S., McArdle, Patrick F., Geerlings, Mirjam I., van der Graaf, Yolanda, de Bakker, Paul I.W., Asselbergs, Folkert W., Srikanth, Velandai, Thomson, Russell, McWhirter, Rebekah, Moran, Chris, Callisaya, Michele, Phan, Thanh, Rutten-Jacobs, Loes C.A., Bevan, Steve, Tzourio, Christophe, Mather, Karen A., Sachdev, Perminder S., van Duijn, Cornelia M., Worrall, Bradford B., Dichgans, Martin, Kittner, Steven J., Markus, Hugh S., Ikram, Mohammad A., Fornage, Myriam, Launer, Lenore J., Seshadri, Sudha, Longstreth, W.T., Jr, Debette, Stéphanie, Almgren, Peter, Anderson, Christopher D., Arnett, Donna K., Attia, John, Ay, Hakan, Benavente, Oscar R., Bevan, Steve, Brown, Robert D., Bustamante, Mariana, Cheng, Yu-Ching, Cole, John W., Cotlarciuc, Ioana, Cruchaga, Carlos, de Bakker, Paul IW., Delavaran, Hossein, Dichgans, Martin, Engström, Gunnar, Fornage, Myriam, Grewal, Raji P., Heitsch, Laura, Holliday, Elizabeth, Ibanez, Laure, Ilinca, Andreea, Irvin, Marguerite R., Jackson, Rebecca D., Jern, Christina, Jimenez-Conde, Jordi, Johnson, Julie A., Jood, Katarina, Kissela, Brett M., Kittner, Steven J., Kleindorfer, Dawn O., Labovitz, Daniel, Laurie, Cathy C., Lee, Jin-Moo, Lemmens, Robin, Levi, Christopher, Li, Linxin, Lindgren, Arne G., Maguire, Jane, Markus, Hugh S., McArdle, Patrick F., Melander, Olle, Meschia, James F., Mitchell, Braxton D., Müller-Nurasyid, Martina, Norrving, Bo, Peddareddygari, Leema Reddy, Pera, Joanna, Pulit, Sara L., Rexrode, Kathryn, Ribasés, Marta, Roquer, Jaume, Rost, Natalia S., Rothwell, Peter M., Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Soriano-Tárraga, Carolina, Stanne, Tara, Stauch, Konstantin, Stine, O C., Sudlow, Cathie LM., Thijs, Vincent N.S., Wasssertheil-Smoller, Sylvia, Weir, David, Williams, Stephen R., Wong, Quenna, Woo, Daniel, Worrall, Bradford B., Xu, Huichun, Seshadri, Sudha, Hyacinth, Hyacinth I, Marini, Sandro, Nyquist, Paul, Lewis, Cathryn, Hansen, Bjorn, Norrving, Bo, Rosand, Jonathan, Biffi, Alessandro, Kourkoulis, Christina, Anderson, Chris, Giese, Anne-Katrin, Sacco, Ralph, Sharma, Pankaj, Chung, Jong-Won, Kim, Gyeong-Moon, Lubitz, Steven, Bourcier, Romain, Howson, Joanna, Granata, Alessandra, Drazyk, Anna, Markus, Hugh, Wardlaw, Joanna, Mitchell, Braxton, Cole, John, Hopewell, Jemma, Walters, Robin, Turnbull, Iain, Worrall, Bradford, Bis, Josh, Reiner, Alex, Dhar, Raj, Heitsch, Laura, Lee, Jin-Moo, Prasad, Kameshwar, Sarnowski, Chloé, Aparicio, Hugo Javier, Yang, Qiong, Chasman, Daniel, Rexrode, Kathryn, Phuah, Chia-Ling, Liu, Guiyou, Elkind, Mitchell, Lange, Leslie, Rost, Natalia, James, Michael, Stewart, Jill, Vojinovic, Dina, Thijs, Vincent, Parati, Eugenio, Boncoraglio, Giorgio, Zand, Ramin, Bijlenga, Philippe, Selim, Magdy, Grond-Ginsbach, Caspar, Strbian, Daniel, Tomppo, Liisa, Sallinen, Hanne, Pfeiffer, Dorothea, Torres, Nuria, Barboza, Miguel, Laarman, Melanie, Carriero, Roberta, Holliday, Elizabeth, Jimenez-Conde, Jordi, Soriano, Carolina, Gill, Dipender, Debette, Stephanie, Mishra, Aniket, Wu, Jer-Yuarn, Ko, Tai-Ming, Bione, Silvia, Jood, Katarina, Tatlisumak, Turgut, Holmegaard, Lukas, Yue, Suo, bersano, Anna, Pera, Joanna, Slowik, Agnieszka, Levi, Christopher, Schlicht, Kristina, Lemmens, Robin, Ninomiya, Toshiharu, Oberstein, Saskia Lesnik, Lee, Tsong-Hai, Malik, Rainer, Dichgans, Martin, Lindgren, Arne, Wasselius, Johan, Drake, Mattias, Melander, Olle, Stenman, Martin, Ilinca, Andreea, Crawford, Katherine, Lena, Umme, Mateen, Farrah, Ay, Hakan, Wu, Ona, Schirmer, Markus, Cramer, Steve, Golland, Polina, Brown, Robert, Meschia, James, Ross, Owen A., Pare, Guillaume, Chong, Mike, Rundek, Tatjana, Gwinn, Katrina, Chen, Christopher, Koenig, Jim, Giralt, Eva, Saleheen, Danish, de Leeuw, Frank-Erik, Klijn, Karin, Kamatani, Yoichiro, Kubo, Michiaki, Okada, Yukinori, Pedersen, Annie, Olsson, Maja, Martín, Juan José, Xu, Huichun, Tan, Eng King, Frid, Petrea, Lee, Chaeyoung, Tregouet, David, Leung, Thomas, Choy, Richard, Jern, Christina, Loo, Keat Wei, Rinkel, Gabriel, Franca, Paulo, Cendes, Iscia, Carrera, Caty, Fernandez-Cadenas, Israel, Montaner, Joan, Kim, Helen, Owolabi, Mayowa, Sofat, Reecha, Bakker, Mark, Ruigrok, Ynte, Hauer, Allard, Pulit, Sara L., van der Laan, Sander W., Irvin, Ryan, Sargurupremraj, Murali, Pezzini, Alessandro, Abd-Allah, Foad, Liebeskind, David, Traylor, Matthew, Tan, Rhea, Danesh, John, Rutten-Jacobs, Loes, Donatti, Amanda, Avelar, Wagner, Broderick, Joseph, Woo, Daniel, Sudlow, Cathie, Rannikmae, Kristiina, McDonough, Caitrin Wheeler, van Agtmael, Tom, Walters, Matthew, Söderholm, Martin, Lorentzen, Erik, Olsson, Sandra, Stanne, Tara, Olsson, Martina, Akinyemi, Rufus, Cotlatciuc, Ioana, McArdle, Patrick, Dave, Tushar, Kittner, Steven, Attia, John, Faber, James E, Millwood, Iona, Márquez, Elsa Valdés, Mancuso, Michelangelo, Vibo, Riina, Korv, Janika, Maguire, Jane, Fornage, Myriam, Majersik, Jennifer, DeHavenon, Adam, Alexander, Matthew, Sale, Michele, Southerland, Andrew, Owens, Debra, Psaty, Bruce, Longstreth, W. T., Jr, Wolfe, Stacey Quintero, Langefeld, Carl, Cruchaga, Carlos, Konrad, Jan, Sheth, Kevin, Falcone, Guido, Donahue, Kathleen, Simpkins, Alexis N, Liang Byorn, Tan Wei, Chan, Bernard, Clatworthy, Phil, Florez, Jose, Harshfield, Eric, Hozawa, Atsushi, Hsu, Chung, Hu, Chaur-Jong, Ibanez, Laure, Ihara, Masafumi, Lange, Marcos, Lee, Soo Ji, Lee, I-Hui, Musolino, Patricia, Nakatomi, Hirofumi, Park, Kwang-Yeol, Rich, Stephen S, Riley, Chris, Sung, Joohon, Suzuki, Hideaki, Vo, Katie, Washida, Kazuo, Ibenez, Laura Garcia, Slowik, Agnieszka, Hofman, Albert, Algra, Ale, Reiner, Alex P, Doney, Alexander S F, Gschwendtner, Andreas, Ilinca, Andreea, Giese, Anne-Katrin, Lindgren, Arne, Vicente, Astrid M, Norrving, Bo, Nordestgaard, Børge G, Mitchell, Braxton D, Worrall, Bradford B, Psaty, Bruce M, Carty, Cara L, Sudlow, Cathie, Anderson, Christopher D, Levi, Christopher, Satizabal, Claudia L, Palmer, Colin N A, Gamble, Dale M, Woo, Daniel, Saleheen, Danish, Ringelstein, E Bernd, Valdimarsson, Einar, Holliday, Elizabeth, Davies, Gail, Chauhan, Ganesh, Pasterkamp, Gerard, Boncoraglio, Giorgio, Kuhlenbäumer, Gregor, Thorleifsson, Gudmar, Falcone, Guido J, Pare, Guillame, Schmidt, Helena, Delavaran, Hossein, Markus, Hugh S, Aparicio, Hugo J, Deary, Ian, Cotlarciuc, Ioana, Fernandez-Cadenas, Israel, Meschia, James, Hopewell, Jemma C, Liu, Jingmin, Montaner, Joan, Pera, Joanna, Cole, John, Attia, John R, Rosand, Jonathan, Ferro, Jose M, Bis, Joshua, Furie, Karen, Stefansson, Kari, Berger, Klaus, Kostulas, Konstantinos, Rannikmae, Kristina, Ikram, M Arfan, Benn, Marianne, Dichgans, Martin, Farrall, Martin, Pandolfo, Massimo, Traylor, Matthew, Walters, Matthew, Sale, Michele, Nalls, Mike, Fornage, Myriam, van Zuydam, Natalie R, Sharma, Pankaj, Abrantes, Patricia, de Bakker, Paul IW, Higgins, Peter, Lichtner, Peter, Rothwell, Peter M, Amouyel, Philippe, Yang, Qiong, Malik, Rainer, Schmidt, Reinhold, Clarke, Robert, Lemmens, Robin, van der Laan, Sander W, Pulit, Sara L, Abboud, Sherine, Oliveira, Sofia A, Gretarsdottir, Solveig, Debette, Stephanie, Williams, Stephen R, Bevan, Steve, Kittner, Steven J, Seshadri, Sudha, Mosley, Thomas, Battey, Thomas WK, Tatlisumak, Turgut, Thorsteinsdottir, Unnur, Thijs, Vincent NS, Longstreth, W T, Zhao, Wei, Chen, Wei-Min, Cheng, Yu-Ching, Albert, Marilyn S., Albin, Roger L., Apostolova, Liana G., Arnold, Steven E., Asthana, Sanjay, Atwood, Craig S., Baldwin, Clinton T., Barmada, M. Michael, Barnes, Lisa L., Barral, Sandra, Beach, Thomas G., Becker, James T., Beecham, Gary W., Beekly, Duane, Bennett, David A., Bigio, Eileen H., Bird, Thomas D., Blacker, Deborah, Boeve, Bradley F., Boxer, Adam, Burke, James R., Burns, Jeffrey M., Buxbaum, Joseph D., Byrd, Goldie S., Cai, Guiqing, Cairns, Nigel J., Cantwell, Laura B., Cao, Chuanhai, Carlsson, Cynthia M., Carney, Regina M., Carrasquillo, Minerva M., Carroll, Steven L., Chui, Helena C., Clark, David G., Cribbs, David H., Crocco, Elizabeth A., Cruchaga, Carlos, De Jager, Philip L., DeCarli, Charles, Demirci, F. Yesim, Dick, Malcolm, Dickson, Dennis W., Duara, Ranjan, Ertekin-Taner, Nilufer, Evans, Denis A., Faber, Kelley M., Fallin, M. Daniele, Fallon, Kenneth B., Fardo, David W., Farlow, Martin R., Farrer, Lindsay A., Ferris, Steven, Foroud, Tatiana M., Frosch, Matthew P., Galasko, Douglas R., Gearing, Marla, Geschwind, Daniel H., Ghetti, Bernardino, Gilbert, John R., Go, Rodney C.P., Goate, Alison M., Graff-Radford, Neill R., Green, Robert C., Griffith, Patrick, Growdon, John H., Haines, Jonathan L., Hakonarson, Hakon, Hamilton, Ronald L., Hamilton-Nelson, Kara L., Haroutunian, Vahram, Harrell, Lindy E., Honig, Lawrence S., Huebinger, Ryan M., Hulette, Christine M., Hyman, Bradley T., Jicha, Gregory A., Jin, Lee-Way, Jun, Gyungah, Kamboh, M. Ilyas, Karydas, Anna, Kauwe, John S.K., Kaye, Jeffrey A., Kim, Ronald, Kowall, Neil W., Kramer, Joel H., Kukull, Walter A., Kunkle, Brian W., LaFerla, Frank M., Lah, James J., Lang-Walker, Rosalyn, Larson, Eric B., Leverenz, James B., Levey, Allan I., Li, Ge, Lieberman, Andrew P., Logue, Mark W., Lopez, Oscar L., Lunetta, Kathryn L., Lyketsos, Constantine G., Mack, Wendy J., Manly, Jennifer J., Marson, Daniel C., Martin, Eden R., Martiniuk, Frank, Mash, Deborah C., Masliah, Eliezer, Mayeux, Richard, McKee, Ann C., Mesulam, Marsel, Miller, Bruce L., Miller, Carol A., Miller, Joshua W., Montine, Thomas J., Morris, John C., Murrell, Jill R., Naj, Adam C., Obisesan, Thomas O., Olichney, John M., Pankratz, Vernon S., Parisi, Joseph E., Partch, Amanda, Paulson, Henry L., Pericak-Vance, Margaret A., Perry, William, Peskind, Elaine, Petersen, Ronald C., Pierce, Aimee, Poon, Wayne W., Potter, Huntington, Quinn, Joseph F., Raj, Ashok, Raj, Towfique, Raskind, Murray, Reiman, Eric M., Reisberg, Barry, Reitz, Christiane, Ringman, John M., Roberson, Erik D., Rosen, Howard J., Rosenberg, Roger N., Sager, Mark A., Sano, Mary, Saykin, Andrew J., Schellenberg, Gerard D., Schneider, Julie A., Schneider, Lon S., Seeley, William W., Smith, Amanda G., Sonnen, Joshua A., Spina, Salvatore, Stern, Robert A., Swerdlow, Russell H., Tanzi, Rudolph E., Thornton-Wells, Tricia A., Trojanowski, John Q., Troncoso, Juan C., Tsuang, Debby W., Valladares, Otto, Van Deerlin, Vivianna M., Van Eldik, Linda J., Vardarajan, Badri N., Vinters, Harry V., Vonsattel, Jean Paul, Wang, Li-San, Weintraub, Sandra, Welsh-Bohmer, Kathleen A., Williamson, Jennifer, Wingo, Thomas S., Wishnek, Sarah, Woltjer, Randall L., Wright, Clinton B., Younkin, Steven G., Yu, Chang-En, Yu, Lei, Chauhan, Ganesh, Chu, Audrey Y., Fornage, Myriam, Bis, Joshua C., Havulinna, Aki S., Sargurupremraj, Muralidharan, Smith, Albert Vernon, Adams, Hieab H.H., Choi, Seung Hoan, Trompet, Stella, Garcia, Melissa E., Manichaikul, Ani, Teumer, Alexander, Gustafsson, Stefan, Bartz, Traci M., Bellenguez, Céline, Vidal, Jean Sebastien, Jian, Xueqiu, Kjartansson, Olafur, Wiggins, Kerri L., Satizabal, Claudia L., Xue, Flora, Ripatti, Samuli, Liu, Yongmei, Deelen, Joris, Hoed, Marcel den, Heckbert, Susan R., Rice, Kenneth, Smith, Nicholas L., Wong, Quenna, Aparicio, Hugo J., Buring, Julie E., Ridker, Paul M, Berr, Claudine, Dartigues, Jean-François, Hamsten, Anders, Magnusson, Patrik K., Pedersen, Nancy L., Lannfelt, Lars, Lind, Lars, Lindgren, Cecilia M., Morris, Andrew P., Hofman, Albert, Koudstaal, Peter J., Portegies, Marileen LP., Uitterlinden, André G., de Craen, Anton JM, Ford, Ian, Jukema, J. Wouter, Stott, David J, Allen, Norrina B., Sale, Michele M., Johnson, Andrew D, Bennett, David A., De Jager, Philip L., White, Charles C., Grabe, Hans Jörgen, Paulista Markus, Marcello Ricardo, Lopez, Oscar L, Rotter, Jerome I., Nalls, Michael A., Gottesman, Rebecca F., Griswold, Michael E., Knopman, David S., Windham, B. Gwen, Beiser, Alexa, Vartiainen, Erkki, French, Curtis R., Kurth, Tobias, Psaty, Bruce M., Harris, Tamara B., Rich, Stephen S, deStefano, Anita L., Schmidt, Carsten Oliver, Salomaa, Veikko, Mosley, Thomas H., Ingelsson, Erik, van Duijn, Cornelia M., Tzourio, Christophe, Launer, Lenore J, Ikram, M. Arfan, Chasman, Daniel I., Longstreth, W. T., Jr, Seshadri, Sudha, Debette, Stéphanie, Verhaaren, Benjamin F.J., Debette, Stéphanie, Bis, Joshua C., Smith, Jennifer A., Ikram, M. Kamran, Adams, Hieab H., Beecham, Ashley H., Rajan, Kumar B., Lopez, Lorna M., Barral, Sandra, van Buchem, Mark A., van der Grond, Jeroen, Smith, Albert V., Hegenscheid, Katrin, Aggarwal, Neelum T., de Andrade, Mariza, Atkinson, Elizabeth J., Beekman, Marian, Beiser, Alexa S., Blanton, Susan H., Boerwinkle, Eric, Brickman, Adam M., Bryan, R. Nick, Chauhan, Ganesh, Chen, Christopher P.L.H., Chouraki, Vincent, de Craen, Anton J.M., Crivello, Fabrice, Deary, Ian J., Deelen, Joris, De Jager, Philip L., Dufouil, Carole, Elkind, Mitchell S.V., Evans, Denis A., Freudenberger, Paul, Gottesman, Rebecca F., Guðnason, Vilmundur, Habes, Mohamad, Heckbert, Susan R., Heiss, Gerardo, Hilal, Saima, Hofer, Edith, Hofman, Albert, Ibrahim-Verbaas, Carla A., Knopman, David S., Lewis, Cora E., Liao, Jiemin, Liewald, David C.M., Luciano, Michelle, van der Lugt, Aad, Martinez, Oliver O., Mayeux, Richard, Mazoyer, Bernard, Nalls, Mike, Nauck, Matthias, Niessen, Wiro J., Oostra, Ben A., Psaty, Bruce M., Rice, Kenneth M., Rotter, Jerome I., von Sarnowski, Bettina, Schmidt, Helena, Schreiner, Pamela J., Schuur, Maaike, Sidney, Stephen S., Sigurdsson, Sigurdur, Slagboom, P. Eline, Stott, David J.M., van Swieten, John C., Teumer, Alexander, Töglhofer, Anna Maria, Traylor, Matthew, Trompet, Stella, Turner, Stephen T., Tzourio, Christophe, Uh, Hae-Won, Uitterlinden, André G., Vernooij, Meike W., Wang, Jing J., Wong, Tien Y., Wardlaw, Joanna M., Windham, B. Gwen, Wittfeld, Katharina, Wolf, Christiane, Wright, Clinton B., Yang, Qiong, Zhao, Wei, Zijdenbos, Alex, Jukema, J. Wouter, Sacco, Ralph L., Kardia, Sharon L.R., Amouyel, Philippe, Mosley, Thomas H., Longstreth, W. T., Jr, DeCarli, Charles C., van Duijn, Cornelia M., Schmidt, Reinhold, Launer, Lenore J., Grabe, Hans J., Seshadri, Sudha S., Ikram, M. Arfan, Fornage, Myriam, Bis, Joshua C., Kavousi, Maryam, Franceschini, Nora, Isaacs, Aaron, Abecasis, Gonçalo R, Schminke, Ulf, Post, Wendy, Smith, Albert V., Cupples, L. Adrienne, Markus, Hugh S, Schmidt, Reinhold, Huffman, Jennifer E., Lehtimäki, Terho, Baumert, Jens, Münzel, Thomas, Heckbert, Susan R., Dehghan, Abbas, North, Kari, Oostra, Ben, Bevan, Steve, Stoegerer, Eva-Maria, Hayward, Caroline, Raitakari, Olli, Meisinger, Christa, Schillert, Arne, Sanna, Serena, Völzke, Henry, Cheng, Yu-Ching, Thorsson, Bolli, Fox, Caroline S., Rice, Kenneth, Rivadeneira, Fernando, Nambi, Vijay, Halperin, Eran, Petrovic, Katja E., Peltonen, Leena, Wichmann, H. Erich, Schnabel, Renate B., Dörr, Marcus, Parsa, Afshin, Aspelund, Thor, Demissie, Serkalem, Kathiresan, Sekar, Reilly, Muredach P., Taylor, Kent, Uitterlinden, Andre, Couper, David J., Sitzer, Matthias, Kähönen, Mika, Illig, Thomas, Wild, Philipp S., Orru, Marco, Lüdemann, Jan, Shuldiner, Alan R., Eiriksdottir, Gudny, White, Charles C., Rotter, Jerome I., Hofman, Albert, Seissler, Jochen, Zeller, Tanja, Usala, Gianluca, Ernst, Florian, Launer, Lenore J., DʼAgostino, Ralph B., Sr, OʼLeary, Daniel H., Ballantyne, Christie, Thiery, Joachim, Ziegler, Andreas, Lakatta, Edward G., Chilukoti, Ravi Kumar, Harris, Tamara B., Wolf, Philip A., Psaty, Bruce M., Polak, Joseph F, Li, Xia, Rathmann, Wolfgang, Uda, Manuela, Boerwinkle, Eric, Klopp, Norman, Schmidt, Helena, Wilson, James F, Viikari, Jorma, Koenig, Wolfgang, Blankenberg, Stefan, Newman, Anne B., Witteman, Jacqueline, Heiss, Gerardo, van Duijn, Cornelia, Scuteri, Angelo, Homuth, Georg, Mitchell, Braxton D., Gudnason, Vilmundur, and O’Donnell, Christopher J.
- Published
- 2019
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25. Significance of admission hypoalbuminemia in acute intracerebral hemorrhage
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Morotti, Andrea, Marini, Sandro, Lena, Umme K., Crawford, Katherine, Schwab, Kristin, Kourkoulis, Christina, Ayres, Alison M., Edip Gurol, M., Viswanathan, Anand, Greenberg, Steven M., Anderson, Christopher D., Rosand, Jonathan, and Goldstein, Joshua N.
- Published
- 2017
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26. Lymphopenia, Infectious Complications, and Outcome in Spontaneous Intracerebral Hemorrhage
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Morotti, Andrea, Marini, Sandro, Jessel, Michael J., Schwab, Kristin, Kourkoulis, Christina, Ayres, Alison M., Gurol, M. Edip, Viswanathan, Anand, Greenberg, Steven M., Anderson, Christopher D., Goldstein, Joshua N., and Rosand, Jonathan
- Published
- 2017
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27. Journal Club: Florbetapir imaging in cerebral amyloid angiopathy-related hemorrhages
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Charidimou, Andreas, Giese, Anne-Katrin, Pasi, Marco, van Veluw, Susanne J., Xiong, Li, Fotiadis, Panagiotis, Marini, Sandro, Schirmer, Markus D., and Viswanathan, Anand
- Published
- 2018
- Full Text
- View/download PDF
28. Cerebrovascular Disease Knowledge Portal: An Open-Access Data Resource to Accelerate Genomic Discoveries in Stroke
- Author
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Crawford, Katherine M., Gallego-Fabrega, Cristina, Kourkoulis, Christina, Miyares, Laura, Marini, Sandro, Flannick, Jason, Burtt, Noel P., von Grotthuss, Marcin, Alexander, Benjamin, Costanzo, Maria C., Vaishnav, Neil H., Malik, Rainer, Hall, Jennifer L., Chong, Michael, Rosand, Jonathan, and Falcone, Guido J.
- Published
- 2018
- Full Text
- View/download PDF
29. Cerebellar Hematoma Location: Implications for the Underlying Microangiopathy
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Pasi, Marco, Marini, Sandro, Morotti, Andrea, Boulouis, Gregoire, Xiong, Li, Charidimou, Andreas, Ayres, Alison M., Lee, Myung Joo, Biffi, Alessandro, Goldstein, Joshua N., Rosand, Jonathan, Gurol, M. Edip, Greenberg, Steven M., and Viswanathan, Anand
- Published
- 2018
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30. Abstract WMP80: Pleiotropy Analyses Of Between Intracerebral Hemorrhage And β-amyloid Related Phenotypes
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Marini, Sandro, primary, Chung, Jaeyoon, additional, Han, Xudong, additional, Farrer, Lindsay A, additional, Rosand, Jonathan, additional, Romero, Rafael J, additional, and Anderson, Christopher D, additional
- Published
- 2022
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31. Interactions Between Kidney Function and Cerebrovascular Disease: Vessel Pathology That Fires Together Wires Together
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Marini, Sandro, primary, Georgakis, Marios K., additional, and Anderson, Christopher D., additional
- Published
- 2021
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32. White Matter Microstructural Damage in Small Vessel Disease Is Associated With Montreal Cognitive Assessment But Not With Mini Mental State Examination Performances: Vascular Mild Cognitive Impairment Tuscany Study
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Pasi, Marco, Salvadori, Emilia, Poggesi, Anna, Ciolli, Laura, Del Bene, Alessandra, Marini, Sandro, Nannucci, Serena, Pescini, Francesca, Valenti, Raffaella, Ginestroni, Andrea, Toschi, Nicola, Diciotti, Stefano, Mascalchi, Mario, Inzitari, Domenico, and Pantoni, Leonardo
- Published
- 2015
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33. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
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Bakker, Mark K., van der Spek, Rick A.A., van Rheenen, Wouter, Morel, Sandrine, Bourcier, Romain, Hostettler, Isabel C., Alg, Varinder S., van Eijk, Kristel R., Koido, Masaru, Akiyama, Masato, Terao, Chikashi, Matsuda, Koichi, Walters, Robin G., Lin, Kuang, Li, Liming, Millwood, Iona Y., Chen, Zhengming, Rouleau, Guy A., Zhou, Sirui, Rannikmäe, Kristiina, Sudlow, Cathie L.M., Houlden, Henry, van den Berg, Leonard H., Dina, Christian, Naggara, Olivier, Gentric, Jean-Christophe, Shotar, Eimad, Eugène, François, Desal, Hubert, Winsvold, Bendik S., Børte, Sigrid, Johnsen, Marianne Bakke, Brumpton, Ben M., Sandvei, Marie Søfteland, Willer, Cristen J., Hveem, Kristian, Zwart, John-Anker, Verschuren, W. M. Monique, Friedrich, Christoph M., Hirsch, Sven, Schilling, Sabine, Dauvillier, Jérôme, Martin, Olivier, Martinsen, Amy E, Aamodt, Anne Hege, Skogholt, Anne Heidi, Sandset, Else Charlotte, Kristoffersen, Espen S, Ellekjaer, Hanne, Heuch, Ingrid, Nielsen, Jonas Bille, Hagen, Knut, Fritsche, Lars, Thomas, Laurent F., Pedersen, Linda, Gabrielsen, Maiken E, Vigeland, Maria Dehli, Holmen, Oddgeir, Zhou, Wei, Chen, Junshi, Chen (PI), Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li (PI), Liming, Liu, Depei, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Boxall, Ruth, Bennett, Derrick, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gan, Wei, Gilbert, Simon, Hacker, Alex, Hill, Michael, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Lancaster, Garry, Lewington, Sarah, McDonnell, John, Millwood, Iona, Nie, Qunhua, Ryder, Paul, Sansome, Sam, Schmidt-Valle, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Bian, Zheng, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zou, Mingyuan, Yan, Shichun, Zhou, Xue, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Chen, Jinyan, Fu, Yan, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Hua, Yujie, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin Sisi Wang, Yulu, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhou, Ding Zhang, Zhou, Gang, Feng, Shixian, Chang, Ling, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Gong, Weiwei, Wang, Meng, Xie, Kaixu, Chen, Lingli, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Zhang, Libo, Nagai, Akiko, Muto, Kaori, Hirata, Makoto, Morisaki, Takayuki, Yamashita, Yasushi, Kamatani, Yoichiro, Kambara, Yoko, Murakami, Yoshinori, Masumoto, Akihide, Nagayama, Satoshi, Miki, Yoshio, Yoshimori, Kozo, Fujioka, Tomoaki, Takata, Ryo, Yamaji, Ken, Takahashi, Kazuhisa, Asai, Satoshi, Takahashi, Yasuo, Minami, Shiro, Yamaguchi, Hiroki, Koretsune, Yukihiro, Nishizawa, Yasuko, Kodama, Ken, Kutsumi, Hiromu, Suzuki, Takao, Sinozaki, Nobuaki, Murayama, Shigeo, Furukawa, Yoichi, Yamanashi, Yuji, Papagiannaki, Chrisanthi, Piotin, Michel, Trystram, Denis, Edjlali-Goujon, Myriam, Boulouis, Grégoire, Rodriguez, Christine, Hassen, Waghi Ben, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Levrier, Olivier, Aguettaz, Pierre, Combaz, Xavier, Pasco, Anne, l’Allinec, Vincent, Bintner, Marc, Molho, Marc, Pascale, Gauthier, Chivot, Cyril, Costalat, Vincent, Darganzil, Cyril, Bonafé, Alain, Januel, Anne Christine, Michelozzi, Caterina, Cognard, Christophe, Bonneville, Fabrice, Tall, Philippe, Darcourt, Jean, Biondi, Alessandra, Iosif, Cristina, Ferre, Jean Christophe, Gauvrit, Jean Yves, Eugene, François, Raoult, Hélène, Gentric, Jean Christophe, Ognard, Julien, Anxionnat, René, Gory, Benjamin, Bracard, Serge, Derelle, Anne Laure, Tonnelet, Romain, Spelle, Laurent, Ikka, Léon, Ozanne, Augustin, Gallas, Sophie, Caroff, Jildaz, Achour, Nidal Ben, Moret, Jacques, Chabert, Emmanuel, Berge, Jérôme, Marnat, Gaultier, Barreau, Xavier, Gariel, Florent, Clarencon, Frédéric, Aggour, Mohammed, Ricolfi, Frédéric, Chavent, Adrien, Thouant, Pierre, Lebidinsky, Pablo, Lemogne, Brivael, Herbreteau, Denis, Bibi, Richard, Janot, Kevin, Pierot, Laurent, Soize, Sébastien, Labeyrie, Marc Antoine, Vandendries, Christophe, Kazemi, Appoline, Leclerc, Xavier, Pruvo, Jean Pierre, Bricout, Nicolas, Velasco, Stéphane, Boucebci, Samy, Lemmens, Robin, Pandolfo, Massimo, Bodenant, Marie, Louillet, Fabien, Mas, Jean-Louis, Deltour, Sandrine, Leder, Sara, Léger, Anne, Canaple, Sandrine, Godefroy, Olivier, Giroud, Maurice, Jacquin, Agnès, Moulin, Thierry, Vuillier, Fabrice, Tzourio, Christophe, Santos, Michael Dos, Malik, Rainer, Hausser, Ingrid, Thomas-Feles, Constanze, Weber, Ralf, Grond-Ginsbach, Caspar, Hacke, Werner, Giossi, Alessia, Volonghi, Irene, Costa, Paolo, del Zotto, Elisabetta, Morotti, Andrea, Poli, Loris, Muiesan, Maria Lorenza, Salvetti, Massimo, Rosei, Enrico Agabiti, Lanfranconi, Silvia, Baron, Pierluigi, Ferrarese, Carlo, Susani, Emanuela, Giacalone, Giacomo, Paolucci, Stefano, Palmirotta, Raffaele, Guadagni, Fiorella, Paciaroni, Maurizio, Ballabio, Elena, Parati, Eugenio A., Fluri, Felix, Hatz, Florian, Gisler, Dominique, Amort, Margareth, Bevan, Steve, James, Tom, Olsson, Sandra, Holmegaard, Lukas, Altintas, Ayse, Martin, Juan José, Kittner, Steven, Mitchell, Braxton, Stine, Colin, O’Connell, Jeff, Dueker, Nicole, Koudstaal, Peter J., de Lau, Lonneke M.L., Hofman, Albert, Verhaaren, Benjamin F, Uitterlinden, Andre G, Montaner, Joan, Mendioroz, Maite, Yadav, Sunaina, Khan, Muhammad Saleem, Wilder, Michael, van Dijk, Ewoud, Maaijwee, Noortje, Rutten-Jacobs, Loes, Kramer, Jamie, Malik, Shaneela, Brott, Thomas G, Brown, Robert D, Singleton, Andrew, Hardy, John, Rich, Stephen S, Tanislav, Christian, Jungehülsing, Jan, Werring, David, Alg, Varinder, Hostettler, Isabel, Bonner, Stephen, Walsh, Daniel, Bulters, Diederik, Kitchen, Neil, Brown, Martin, Grieve, Joan, Roberts, Gareth, Jones, Timothy, Critchley, Giles, Sharma, Pankaj, Nelson, Richard, Whitfield, Peter, Ross, Stuart, Patel, Hiren, Eldridge, Paul, Saastamoinen, Kari, Patel, Umang, Lawrance, Enas, Vandabona, Subha, Mendelow, David, Teal, Rachel, Warner, Orlando, Kirkpatrick, Peter, Seshadri, Sudha, Kilarski, Laura, Hyacinth, Hyacinth I, Oliveira, Jamary, Marini, Sandro, Nyquist, Paul, Lewis, Cathryn, Norrving, Bo, Smith, Gustav, Rosand, Jonathan, Biffi, Alessandro, Kourkoulis, Christina, Anderson, Chris, Giese, Anne-Katrin, Bang, Oh Young, Chung, Jong-Won, Kim, Gyeong-Moon, Zhuang, Qishuai, Sheu, Wayne, Smalley, June, Howson, Joanna, Granata, Alessandra, Markus, Hugh, Wardlaw, Joanna, Cole, John, Thalamuthu, Anbupalam, Hopewell, Jemma, Worrall, Bradford, Bis, Josh, Tirschwell, David, Reiner, Alex, Dhar, Raj, Lee, Jin-Moo, Mortenson, Janne, Wassertheil-Smoller, Sylvia, Prasad, Kameshwar, Fisher, Mark, Traenka, Christopher, Wang, Xingwu, Wang, Yongjun, Rouanet, Francois, Sibon, Igor, Sarnowski, Chloé, Maillard, Pauline, Aparicio, Hugo Javier, Dupuis, Josee, Yang, Qiong, Luvizutto, Gustavo, Chasman, Daniel, Rexrode, Kathryn, Harriot, Andrea, Phuah, Chia-Ling, Santo, Gustavo, Gerard, Jen, Liu, Guiyou, Aaron, Sanjith, Christudass, Christhunesa S., Salomi, BSB, Sanghera, Dharambir, Boehme, Amelia, Elkind, Mitchell, Gretarsdottir, Solveig, Lange, Leslie, Rost, Natalia, James, Michael, Stewart, Jill, Goldstein, Larry, Waddy, Salina, Vojinovic, Dina, Ikram, Arfan, Thijs, Vincent, Parati, Eugenio, Boncoraglio, Giorgio, Kooperberg, Charles, Abboud, Sherrine, Zand, Ramin, Bijlenga, Philippe, Selim, Magdy, Happola, Olli, Strbian, Daniel, Tomppo, Liisa, Pathak, Abhishek, Pfeiffer, Dorothea, Aires, de Buenos, de Carvalho, Joao Jose Freitas, Ribeiro, Priscila, Torres, Nuria, Barboza, Miguel, Plomaritoglou, Androniki, Bjorkegren, Johan, Chan, Yu-Feng Yvonne, Gudnason, Villi, Jimenez-Conde, Jordi, Soriano, Carolina, Roquer, Jaume, Bentley, Paul, Tournier-Lasserve, Elisabeth, Dufouil, Carole, Debette, Stephanie, Mishra, Aniket, Wee, Lawrence, Siddiqi, Saima, Wu, Jer-Yuarn, Ko, Tai-Ming, Bione, Silvia, Jood, Katarina, Tatlisumak, Turgut, Arauz, Antonio, Korostynski, Michal, Launer, Lenore, Yue, Suo, bersano, anna, Juchniewicz, Karol Józef, Mateusz, Adamski, Pera, Joanna, Wnuk, Marcin, Levi, Christopher, Gusdon, Aaron, Kostulas, Konstantinos, Maxwell, Jessye, Duering, Marco, Jagiella, Jeremiasz, Hata, Jun, Ninomiya, Toshiharu, Nguyen, Vinh, Thorarinsson, Bjorn Logi, Lee, Tsong-Hai, Rakitko, Alexandr, Dichgans, Martin, Lindgren, Arne, Wasselius, Johan, Drake, Mattias, Stenman, Martin, Ilinca, Andreea, Staals, Julie, Sadr-Nabavi, Ariane, Crawford, Katherine, Lena, Umme, Mateen, Farrah, Ay, Hakan, Wu, Ona, Schirmer, Markus, Romero, Javier, Cramer, Steve, Golland, Polina, Mueller, Bertram, Brown, Robert, Meschia, James, Ross, Owen A., Pare, Guillaume, Chong, Mike, mansour, Ossama yassin, Karaszewski, Bartosz, Enzinger, Christian, Schmidt, Reinhold, Seiler, Stephan, Pichler, Alexander, Ovbiagele, Bruce, Yamada, Yoshiji, Rundek, Tatjana, Blanton, Susan, P, John, Chern, Joseph, O'Donnell, Chris, Corriveau, Roderick, Bhattacharya, Pallab, Gwinn, Katrina, CHANDRA, BHARATENDU, Chen, Christopher, Kalaria, Raj, Koenig, Jim, Singh, Om Prakash, Olugbodi, Akintomi, Giralt, Eva, Saleheen, Danish, de Leeuw, Frank-Erik, Klijn, Karin, Olesen, Jes, Kubo, Michiaki, Spence, David, Pedersen, Annie, Olsson, Maja, Martín, Juan José, Braga, Gabriel, Xu, Huichun, Assimes, Tim, Raskurazhev, Anton, Lee, Wei Ling, Burri, Philippe, Frid, Petrea, GmbH, Heilbronn, Deng, Zhen, Habibi-koolaee, Mahdi, Vijayan, Murali, Leung, Thomas, Wong, Lawrence, Mok, Vincent, Choy, Richard, Jern, Christina, Lebedeva, Elena, Farrall, Martin, Jiayuan, Xu, Loo, Keat Wei, Rinkel, Gabriel, Magnus, Rudolf, Goncalves, Anderson, Franca, Paulo, Cendes, Iscia, Carrera, Caty, Fernandez-Cadenas, Israel, Kim, Helen, Rolfs, Arndt, Owolabi, Mayowa, Bakker, Mark, Ruigrok, Ynte, Hauer, Allard, Pulit, Sara L., Algra, Ale, van der Laan, Sander W., Macleod, Mary, Howard, George, Tiwari, Hemant, Irvin, Ryan, Albright, Karen C., Perry, Rodney, Kidwell, Chelsea, Pavlovic, Aleksandra, Sargurupremraj, Murali, Schilling, Sabrina, Pezzini, Alessandro, Abd-Allah, Foad, DeCarli, Charles, Liebeskind, David, Traylor, Matthew, Tan, Rhea, Danesh, John, Larsson, Susanna C., Rutten, Loes, Donatti, Amanda, Avelar, Wagner, Broderick, Joseph, Woo, Daniel, Kissela, Brett, Ibenez, Laura Garcia, Salman, Rustam, Sudlow, Cathie, McDonough, Caitrin Wheeler, Silliman, Scott, Magvanjav, Oyunbileg, van Agtmael, Tom, Walters, Matthew, Lorentzen, Erik, Stanne, Tara, Olsson, Martina, Nakagawa, Kazuma, Akinyemi, Rufus, Cotlatciuc, Ioana, O'Connell, Jeff, Sparks, Mary, Sorkin, John, Dave, Tushar, Naylor, Jill, Brown, Devin, Du, Rose, Kulik, Tobias B., Attia, John, Faber, James E, Rothwell, Peter, Márquez, Elsa Valdés, Mancuso, Michelangelo, Souza, Doralina Brum, de Silva, Ranil, Vibo, Riina, Korv, Janika, Maguire, Jane, Fornage, Myriam, Illoh, Kachikwu, Milewicz, Dianna, Majersik, Jennifer, DeHavenon, Adam, Kalani, Yashar, Alexander, Matthew, Cushman, Mary, Sale, Michele, Owens, Debra, Keene, Keith, Rich, Stephe, Psaty, Bruce, Longstreth, Will, Atadzhanov, Masharip, Wolfe, Stacey Quintero, Langefeld, Carl, Bushnell, Cheryl, Cruchaga, Carlos, Konrad, Jan, Liu, Junfeng, Sheth, Kevin, Falcone, Guido, Donahue J, Kathleen, Jones, Gregory T., Bown, Matthew J., Ko, Nerissa U., Coleman, Jonathan R.I., Breen, Gerome, Zaroff, Jonathan G., Klijn, Catharina J.M., Sargurupremraj, Muralidharan, Amouyel, Philippe, Debette, Stéphanie, Rinkel, Gabriel J.E., Worrall, Bradford B., Slowik, Agnieszka, Gaál-Paavola, Emilia I., Niemelä, Mika, Jääskeläinen, Juha E., von Und Zu Fraunberg, Mikael, Lindgren, Antti, Broderick, Joseph P., Werring, David J., Redon, Richard, Veldink, Jan H., Ruigrok, Ynte M., Stroke, HUNT All-In, Group, China Kadoorie Biobank Collaborative, Consortium, BioBank Japan Project, Group, ICAN Study, Group, CADISP, investigators, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study, (ISGC), International Stroke Genetics Consortium, Morel, Sandrine, and Bijlenga, Philippe Alexandre Pierre
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genetics [Blood Pressure] ,Medizin ,Genome-wide association study ,Blood Pressure ,Disease ,ddc:616.07 ,Bioinformatics ,616: Innere Medizin und Krankheiten ,0302 clinical medicine ,Risk Factors ,physiopathology [Hypertension] ,genetics [Genetic Predisposition to Disease] ,Genetic risk factor ,Stroke ,0303 health sciences ,Smoking ,genetics [Smoking] ,genetics [Intracranial Aneurysm] ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Cerebrovascular disorder ,3. Good health ,genetics [European Continental Ancestry Group] ,Hypertension ,genetics [Polymorphism, Single Nucleotide] ,Subarachnoid hemorrhage ,pathology [Intracranial Aneurysm] ,genetics [White People] ,Biology ,Genetic correlation ,pathology [Endothelial Cells] ,Polymorphism, Single Nucleotide ,Article ,White People ,03 medical and health sciences ,Aneurysm ,Asian People ,ddc:570 ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,cardiovascular diseases ,030304 developmental biology ,genetics [Subarachnoid Hemorrhage] ,genetics [Asian Continental Ancestry Group] ,572: Biochemie ,genetics [Asian People] ,pathology [Subarachnoid Hemorrhage] ,adverse effects [Smoking] ,Endothelial Cells ,Subarachnoid Hemorrhage ,medicine.disease ,Intracranial aneurysm ,Genetic architecture ,ddc:616.8 ,Case-Control Studies ,genetics [Hypertension] ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
An author correction to this article published in December 2020 is available at https://doi.org/10.1038/s41588-020-00760-4. Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.
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- 2021
34. Rare Missense Functional Variants at COL4A1 and COL4A2 in Sporadic Intracerebral Hemorrhage
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Chung, Jaeyoon, primary, Hamilton, Graham, additional, Kim, Minsup, additional, Marini, Sandro, additional, Montgomery, Bailey, additional, Henry, Jonathan, additional, Cho, Art E., additional, Brown, Devin L., additional, Worrall, Bradford B., additional, Meschia, James F., additional, Silliman, Scott L., additional, Selim, Magdy, additional, Tirschwell, David L., additional, Kidwell, Chelsea S., additional, Kissela, Brett, additional, Greenberg, Steven M., additional, Viswanathan, Anand, additional, Goldstein, Joshua N., additional, Langefeld, Carl D., additional, Rannikmae, Kristiina, additional, Sudlow, Catherine L.M., additional, Samarasekera, Neshika, additional, Rodrigues, Mark, additional, Al-Shahi Salman, Rustam, additional, Prendergast, James G.D., additional, Harris, Sarah E., additional, Deary, Ian, additional, Woo, Daniel, additional, Rosand, Jonathan, additional, Van Agtmael, Tom, additional, and Anderson, Christopher D., additional
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- 2021
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35. Contribution of Racial and Ethnic Differences in Cerebral Small Vessel Disease Subtype and Burden to Risk of Cerebral Hemorrhage Recurrence
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Castello, Juan Pablo, primary, Pasi, Marco, additional, Abramson, Jessica R., additional, Rodriguez-Torres, Axana, additional, Marini, Sandro, additional, Demel, Stacie, additional, Gilkerson, Lee, additional, Kubiszewski, Patryk, additional, Charidimou, Andreas, additional, Kourkoulis, Christina, additional, DiPucchio, Zora, additional, Schwab, Kristin, additional, Gurol, M. Edip, additional, Viswanathan, Anand, additional, Anderson, Christopher D., additional, Langefeld, Carl D., additional, Flaherty, Matthew L., additional, Towfighi, Amytis, additional, Greenberg, Steven M., additional, Woo, Daniel, additional, Rosand, Jonathan, additional, and Biffi, Alessandro, additional
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- 2021
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36. Corrigendum to ‘Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children’ [Psychoneuroendocrinology 113 March (2020) 104484]
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Marini, Sandro, Davis, Kathryn A., Soare, Thomas W., Zhu, Yiwen, Suderman, Matthew J., Simpkin, Andrew J., Smith, Andrew D.A.C., Wolf, Erika J., Relton, Caroline L., and Dunn, Erin C.
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- 2020
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37. Cerebral microbleeds in patients with mild cognitive impairment and small vessel disease: The Vascular Mild Cognitive Impairment (VMCI)-Tuscany study
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Valenti, Raffaella, Del Bene, Alessandra, Poggesi, Anna, Ginestroni, Andrea, Salvadori, Emilia, Pracucci, Giovanni, Ciolli, Laura, Marini, Sandro, Nannucci, Serena, Pasi, Marco, Pescini, Francesca, Diciotti, Stefano, Orlandi, Giovanni, Cosottini, Mirco, Chiti, Alberto, Mascalchi, Mario, Bonuccelli, Ubaldo, Inzitari, Domenico, Pantoni, Leonardo, VMCI Tuscany Study Group, Valenti, Raffaella, Del Bene, Alessandra, Poggesi, Anna, Ginestroni, Andrea, Salvadori, Emilia, Pracucci, Giovanni, Ciolli, Laura, Marini, Sandro, Nannucci, Serena, Pasi, Marco, Pescini, Francesca, Diciotti, Stefano, Orlandi, Giovanni, Cosottini, Mirco, Chiti, Alberto, Mascalchi, Mario, Bonuccelli, Ubaldo, Inzitari, Domenico, and Pantoni, Leonardo
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Male ,medicine.medical_specialty ,Neurology ,Cerebral microbleeds ,Clinical features ,Cognition ,Inter-rater agreement ,Mars ,Small vessel disease ,Neurology (clinical) ,Fleiss' kappa ,Neuropsychological Tests ,030204 cardiovascular system & hematology ,Statistics, Nonparametric ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Neuroimaging ,Risk Factors ,Rating scale ,Internal medicine ,medicine ,Humans ,Cognitive Dysfunction ,Prospective Studies ,Psychiatry ,Aged ,Cerebral Hemorrhage ,Aged, 80 and over ,Cerebral microbleed ,Neuropsychology ,Executive functions ,Magnetic Resonance Imaging ,Mar ,Inter-rater reliability ,Clinical feature ,Italy ,Cerebral Small Vessel Diseases ,Cardiology ,Female ,Psychology ,030217 neurology & neurosurgery - Abstract
Background and objectives Cerebral microbleeds (CMBs) are a neuroimaging expression of small vessel disease (SVD). We investigated in a cohort of SVD patients with mild cognitive impairment (MCI): 1) the reliability of the Microbleed Anatomical Rating Scale (MARS); 2) the burden and location of CMBs and their association with cognitive performances, independent of other clinical and neuroimaging features. Methods Patients underwent clinical, neuropsychological (4 cognitive domains), and MRI assessments. CMBs were assessed by three raters. Results Out of the 152 patients (57.2% males; mean age ± SD: 75.5 ± 6.7 years) with gradient-echo (GRE) sequences, 41 (27%) had at least one CMB. Inter-rater agreement for number and location of CMBs ranged from good to very good [multi-rater Fleiss kappa (95%CI): 0.70–0.95]. Lacunar infarcts and some clinical variables (e.g., hypertension and physical activity) were associated with CMBs in specific regions. Total number of CMBs and of those in deep and lobar regions were associated with attention/executive and fluency domains. Discussion MARS is a reliable instrument to assess CMBs in SVD patients with MCI. Nearly one third of these patients had at least one CMB. Total CMBs burden was associated with attention/executive functions and fluency domains impairment, lacunar infarcts, and with some potentially modifiable risk factors.
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- 2016
38. Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke
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Traylor, Matthew, primary, Amin Al Olama, Ali, additional, Lyytikäinen, Leo-Pekka, additional, Marini, Sandro, additional, Chung, Jaeyoon, additional, Malik, Rainer, additional, Dichgans, Martin, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Anderson, Christopher D., additional, Raitakari, Olli T., additional, and Markus, Hugh S., additional
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- 2020
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39. Genetics of Cerebral Small Vessel Disease
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Marini, Sandro, primary, Anderson, Christopher D., additional, and Rosand, Jonathan, additional
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- 2020
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40. Associations of Radiographic Cerebral Small Vessel Disease with Acute Intracerebral Hemorrhage Volume, Hematoma Expansion, and Intraventricular Hemorrhage
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Uniken Venema, Simone M., primary, Marini, Sandro, additional, Brouwers, H. Bart, additional, Morotti, Andrea, additional, Woo, Daniel, additional, Anderson, Christopher D., additional, and Rosand, Jonathan, additional
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- 2019
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41. Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis
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Marini, Sandro, Crawford, Katherine, Morotti, Andrea, Lee, Myung J, Pezzini, Alessandro, Moomaw, Charles J, Flaherty, Matthew L, Montaner, Joan, Roquer, Jaume, Jimenez-Conde, Jordi, Giralt-Steinhauer, Eva, Elosua, Roberto, Cuadrado-Godia, Elisa, Soriano-Tarraga, Carolina, Slowik, Agnieszka, Jagiella, Jeremiasz M, Pera, Joanna, Urbanik, Andrzej, Pichler, Alexander, Hansen, Bjorn M, McCauley, Jacob L, Tirschwell, David L, Selim, Magdy, Brown, Devin L, Silliman, Scott L, Worrall, Bradford B, Meschia, James F, Kidwell, Chelsea S, Testai, Fernando D, Kittner, Steven J, Schmidt, Helena, Enzinger, Christian, Deary, Lan J, Rannikmae, Kristiina, Samarasekera, Neshika, Salman, Rustam Al-Shahi, Sudlow, Catherine L, Klijn, Catharina JM, van Nieuwenhuizen, Koen M, Fernandez-Cadenas, Israel, Delgado, Pilar, Nonving, Bo, Lindgren, Ame, Goldstein, Joshua N, Viswanathan, Anand, Greenberg, Steven M, Falcone, Guido J, Biffi, Alessandro, Langefeld, Carl D, Woo, Daniel, Rosand, Jonathan, Anderson, Christopher D, Smoller, Sylvia, Sorkin, John, Wang, Xingwu, Pikula, Aleksandra, Wolf, Philip, Debette, Stephanie, Seshadri, Sudha, de Bakker, Paul, Chasman, Daniel, Rexrode, Kathryn, Chen, Ida, Rotter, Jerome, Luke, May, Sale, Michelle, Lee, Tsong-Hai, Chang, Ku-Chou, Elkind, Mitchell, Goldstein, Larry, James, Michael Luke, Breteler, Monique, O'Donnell, Chris, Leys, Didier, Carty, Cara, Kidwell, Chelsea, Olesen, Jes, Sharma, Pankaj, Rich, Stephen, Tatlisumak, Turgot, Happola, Olli, Bijlenga, Philippe, Soriano, Carolina, Giralt, Eva, Cotlarcius, Loana, Hardy, John, Korostynski, Michal, Boncoraglio, Giorgio, Ballabio, Elena, Parati, Eugenio, Mateusz, Adamski, Dziedzic, Tomasz, Jagiella, Jeremiasz, Gasowski, Jerzy, Wnuk, Marcin, Olszanecki, Rafaf, Juchniewicz, Karol Jozef, Levi, Christopher, Nyquist, Paul, Cendes, Iscia, Cabral, Norberto, Franca, Paulo, Goncalves, Anderson, Keller, Lina, Crisby, Milita, Kostulas, Konstantinos, Lennnnens, Robin, Ahmadi, Kourosh, Opherk, Christian, Duering, Marco, Dichgans, Martin, Malik, Rainer, Gonik, Mariya, Staals, Julie, Melander, Olle, Burri, Philippe, Sadr-Nabavi, Ariane, Romero, Javier, Anderson, Chris, Falcone, Guido, Brouwers, Bart, Rost, Natalia, Du, Rose, Kourkoulis, Christina, Battey, Thomas, Lubitz, Steven, Mueller-Myhsok, Bertram, Meschia, James, Brott, Thomas, Pare, Guillaume, Schmidt, Reinhold, Seiler, Stephan, Blanton, Susan, Yamada, Yoshiji, Bersano, Anna, Rundek, Tatiana, Sacco, Ralph, Chan, Yu-Feng Yvonne, Gschwendtner, Andreas, Deng, Zhen, Barr, Taura, Gwinn, Katrina, Corriveau, Roderick, Singleton, Andrew, Waddy, Salina, Launer, Lenore, Chen, Christopher, Le, Kim En, Lee, Wei Ling, Tan, Eng King, Olugbodi, Akintomi, Rothwell, Peter, Schilling, Sabrina, Mok, Vincent, Lebedeva, Elena, Jem, Christina, Jood, Katarina, Olsson, Sandra, Kim, Helen, Lee, Chaeyoung, Kilarski, Laura, Markus, Hugh, Peycke, Jennifer, Bevan, Steve, Sheu, Wayne, Chiou, Hung Yi, Chern, Joseph, Giraldo, Elias, Taqi, Muhammad, Jain, Vivek, Lam, Olivia, Howard, George, Kittner, Steven, Mitchell, Braxton, Cole, John, O'Connell, Jeff, Milewicz, Dianna, Illoh, Kachikwu, Worrall, Bradford, Stine, Colin, Karaszewski, Bartosz, Werring, David, Sofat, Reecha, Smalley, June, Lindgren, Arne, Hansen, Bjorn, Norrving, Bo, Smith, Gustav, Martin, Juan Jose, Thijs, Vincent, Klijn, Karin, van't Hof, Femke, Algra, Ale, Macleod, Mary, Perry, Rodney, Arnett, Donna, Padovani, Alessandro, Cramer, Steve, Fisher, Marl, Saleheen, Danish, Broderick, Joseph, Kissela, Brett, Doney, Alex, Sudlow, Cathie, Silliman, Scott, McDonough, Caitrin, Walters, Matthew, Pedersen, Annie, Nakagawa, Kazuma, Chang, Christy, Dobbins, Mark, McArdle, Patrick, Chang, Yu-Ching, Brown, Robert, Brown, Devin, Holliday, Elizabeth, Kalaria, Raj, Maguire, Jane, Hunter, John, Attia, John, Farrall, Martin, Giese, Anne-Katrin, Fomage, Myriam, Majersik, Jennifer, Cushman, Maly, Keene, Keith, Bennett, Siiri, Tirschwell, David, Psaty, Bruce, Reiner, Alex, Longstreth, Will, Spence, David, Langefeld, Carl, Bushnell, Cheryl, Heitsch, Laura, Lee, Jin-Moo, Sheth, Kevin, Consortium, Int Genetics, Neurologian yksikkö, Department of Neurosciences, Clinicum, Doctoral Programme in Clinical Research, HUS Neurocenter, RS: Carim - B05 Cerebral small vessel disease, RS: CARIM - R3.03 - Cerebral small vessel disease, and Epidemiology
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Male ,Race ethnicity ,Hemorràgia cerebral ,3124 Neurology and psychiatry ,0302 clinical medicine ,Risk Factors ,WHITES ,BLACKS ,030212 general & internal medicine ,Biological sciences ,Original Investigation ,ALZHEIMER-DISEASE ,African Americans ,Aged, 80 and over ,GENETIC-VARIATION ,Hispanic or Latino ,Middle Aged ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Medical research ,University hospital ,3. Good health ,ETHNICITY ,ALLELE ,Research centre ,Hypertension ,lipids (amino acids, peptides, and proteins) ,Female ,Apolipoprotein E ,Core laboratory ,Hispanic Americans ,medicine.medical_specialty ,COA REDUCTASE INHIBITORS ,European Continental Ancestry Group ,Clinical Neurology ,Raça ,APOE EPSILON-4 ,White People ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,Apolipoproteins E ,Political science ,medicine ,Journal Article ,Online First ,Humans ,Genetic Predisposition to Disease ,cardiovascular diseases ,General hospital ,Aged ,Cerebral Hemorrhage ,Research ,LOBAR ,3112 Neurosciences ,E GENOTYPE ,United States ,nervous system diseases ,Black or African American ,Cognitive epidemiology ,Family medicine ,Case-Control Studies ,Neurology (clinical) ,030217 neurology & neurosurgery - Abstract
Key Points Question Is history of hypertension and apolipoprotein E (APOE) associated with intracerebral hemorrhage risk in participants stratified by self-reported race/ethnicity? Findings In this case-control study of 13 124 adults, having a copy of APOE ε4 alleles increased the risk for lobar intracerebral hemorrhage only in white individuals, but after propensity score matching for hypertension burden, Hispanic individuals showed the same risk of APOE ε4. Meaning APOE ε4 appears to be confirmed as a risk factor for lobar intracerebral hemorrhage in nonwhite populations but is masked by differential hypertension burden in Hispanic individuals; further studies are needed to explore the interactions between APOE alleles and environmental exposures., Importance Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. Objective To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ε4 alleles, the most potent genetic risk factor for ICH. Design, Setting, and Participants This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. Main Outcomes and Measures Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies. Results In total, 13 124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE ε2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P, This case-control study examines whether the risk for intracerebral hemorrhage presented by apolipoprotein E ε4 and ε2 alleles varies by race/ethnicity.
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- 2019
42. Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity
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Marini, Sandro, Crawford, Katherine, Morotti, Andrea, Lee, Myung, Pezzini, Alessandro, Moomaw, Charles, Flaherty, Matthew, Montaner, Joan, Roquer, Jaume, Jimenez-Conde, Jordi, Giralt-Steinhauer, Eva, Elosua, Roberto, Cuadrado-Godia, Elisa, Soriano-Tarraga, Carolina, Słowik, Agnieszka, Jagiełła, Jeremiasz, Pera, Joanna, Urbanik, Andrzej, Pichler, Alexander, Hansen, Bjorn, McCauley, Jacob, Tirschwell, David, Selim, Magdy, Brown, Devin, Silliman, Scott, Worrall, Bradford, Meschia, James, Kidwell, Chelsea, Testai, Fernando, Kittner, Steven, Schmidt, Helena, Enzinger, Christian, Deary, Ian, Rannikmae, Kristiina, Samarasekera, Neshika, Al-Shahi Salman, Rustam, Sudlow, Catherine, Klijn, Catharina, van Nieuwenhuizen, Koen, Fernandez-Cadenas, Israel, Delgado, Pilar, Norrving, Bo, Lindgren, Arne, Goldstein, Joshua, Viswanathan, Anand, Greenberg, Steven, Falcone, Guido, Biffi, Alessandro, Langefeld, Carl, Woo, Daniel, Rosand, Jonathan, Anderson, Christopher, National Institute of Neurological Disorders and Stroke (US), Neurocritical Care Society (US), American Heart Association, Medical Research Council (UK), Age UK, Centre for Cognitive Ageing and Cognitive Epidemiology (UK), Wellcome Trust, Binks Trust, Scottish Funding Council, Chief Scientist Office (UK), Swedish Heart-Lung Foundation, Skåne Regional Council, Skåne University Hospital, The Grand Lodge of Sweden, King Gustaf V and Queen Victoria's Foundation, Lund University, Foundation of Färs & Frosta, Swedish Stroke Association, Ministerio de Sanidad, Servicios Sociales e Igualdad (España), Instituto de Salud Carlos III, and European Commission
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education ,cardiovascular diseases ,nervous system diseases - Abstract
[Importance] Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations., [Objective] To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ε4 alleles, the most potent genetic risk factor for ICH., [Design, Setting, and Participants] This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study., [Main Outcomes and Measures] Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies., [Results] In total, 13 124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE ε2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P, [Conclusions and Relevance] APOE ε4 and ε2 alleles appear to affect lobar ICH risk variably by race/ethnicity, associations that are confirmed in white individuals but can be shown in Hispanic individuals only when the excess burden of hypertension is propensity score–matched; further studies are needed to explore the interactions between APOE alleles and environmental exposures that vary by race/ethnicity in representative populations at risk for ICH., This study was funded by grants K23NS086873, R01NS103924, U01NS069763, R01NS093870, R01AG047975, R01AG026484, P50AG005134, and K23AG02872605 from the NIH National Institute of Neurological Disorders and Stroke; a Yale Pepper Scholar Award (P30AG021342) and the Neurocritical Care Society Research Fellowship (Dr Falcone); an American Heart Association fellowship (18POST34080063) (Dr Marini); and a United Kingdom Medical Research Council/Stroke Association Clinical Research Training Fellowship and a United Kingdom Medical Research Council Senior Clinical Fellowship. The Lothian Birth Cohort 1936 is supported by Age UK (The Disconnected Mind project), the Medical Research Council (MR/M01311/1), and the Centre for Cognitive Ageing and Cognitive Epidemiology (which is funded by the Medical Research Council and the Biotechnology and Biological Sciences Research Council [MR/K026992/1]). The Edinburgh Stroke Study was supported by the Wellcome Trust and the Binks Trust. Sample processing occurred in the Genetics Core Laboratory of the Wellcome Trust Clinical Research Facility, Western General Hospital. Much of the neuroimaging occurred in the Scottish Funding Council Brain Imaging Research Centre, University of Edinburgh, a core area of the Wellcome Trust Clinical Research Facility and part of the Scottish Imaging Network–A Platform for Scientific Excellence collaboration (funded by the Scottish Funding Council and the Chief Scientist Office). Lund Stroke Register is supported by the Swedish Heart and Lung Foundation, Region Skåne, Skåne University Hospital, the Freemasons Lodge of Instruction EOS in Lund, King Gustaf V and Queen Victoria’s Foundation, Lund University, the Foundation of Färs & Frosta (one of Sparbanken Skåne’s ownership Foundations), and the Swedish Stroke Association. ICH case and control recruitment from Spain has been supported by the Spain Ministry of Health Instituto de Salud Carlos III FEDER RD16/0019/0002.INVICTUS-PLUS.
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- 2019
43. Genome-wide association study of cerebral small vessel disease reveals established and novel loci
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Chung, Jaeyoon, primary, Marini, Sandro, additional, Pera, Joanna, additional, Norrving, Bo, additional, Jimenez-Conde, Jordi, additional, Roquer, Jaume, additional, Fernandez-Cadenas, Israel, additional, Tirschwell, David L, additional, Selim, Magdy, additional, Brown, Devin L, additional, Silliman, Scott L, additional, Worrall, Bradford B, additional, Meschia, James F, additional, Demel, Stacie, additional, Greenberg, Steven M, additional, Slowik, Agnieszka, additional, Lindgren, Arne, additional, Schmidt, Reinhold, additional, Traylor, Matthew, additional, Sargurupremraj, Muralidharan, additional, Tiedt, Steffen, additional, Malik, Rainer, additional, Debette, Stéphanie, additional, Dichgans, Martin, additional, Langefeld, Carl D, additional, Woo, Daniel, additional, Rosand, Jonathan, additional, and Anderson, Christopher D, additional
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- 2019
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44. Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction
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Raz, Limor, primary, Bhaskar, Kiran, additional, Weaver, John, additional, Marini, Sandro, additional, Zhang, Quanguang, additional, Thompson, Jeffery F., additional, Espinoza, Candice, additional, Iqbal, Sulaiman, additional, Maphis, Nicole M., additional, Weston, Lea, additional, Sillerud, Laurel O., additional, Caprihan, Arvind, additional, Pesko, John C., additional, Erhardt, Erik B., additional, and Rosenberg, Gary A., additional
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- 2019
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45. Abstract 20: Cross-Phenotype Meta-Analysis of Intracerebral Hemorrhageand Small Vessel Ischemic Stroke Identifies Two Novel Genetic Loci at 2q33 and 13q34
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Chung, Jaeyoon, primary, Marini, Sandro, additional, Traylor, Matthew, additional, Malik, Rainer, additional, Langefeld, Carl D, additional, Woo, Daniel, additional, Rosand, Jonathan, additional, and Anderson, Christopher D, additional
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- 2019
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46. Abstract WP440: Pre-existing Cerebral Atrophy is Associated With Diminished Intracerebral Hemorrhage Severity
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Uniken Venema, Simone M, primary, Marini, Sandro, additional, Brouwers, Bart, additional, Morotti, Andrea, additional, Woo, Daniel, additional, Anderson, Christopher D, additional, and Rosand, Jonathan, additional
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- 2019
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47. A case of atypical early-onset Alzheimer’s disease carrying the missense mutation Thr354Ile in exon 10 of the PSEN1 gene
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Marini, Sandro, Lucidi, Giulia, Tedde, Andrea, Bessi, Valentina, and Nacmias, Benedetta
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- 2013
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48. Carotid dissection in IgG4-related disease: an uncommon cause of amaurosis fugax.
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Marini, Sandro and Feske, Steven K.
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- 2023
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49. Rare Missense Functional Variants at COL4A1and COL4A2in Sporadic Intracerebral Hemorrhage
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Chung, Jaeyoon, Hamilton, Graham, Kim, Minsup, Marini, Sandro, Montgomery, Bailey, Henry, Jonathan, Cho, Art E., Brown, Devin L., Worrall, Bradford B., Meschia, James F., Silliman, Scott L., Selim, Magdy, Tirschwell, David L., Kidwell, Chelsea S., Kissela, Brett, Greenberg, Steven M., Viswanathan, Anand, Goldstein, Joshua N., Langefeld, Carl D., Rannikmae, Kristiina, Sudlow, Catherine L.M., Samarasekera, Neshika, Rodrigues, Mark, Al-Shahi Salman, Rustam, Prendergast, James G.D., Harris, Sarah E., Deary, Ian, Woo, Daniel, Rosand, Jonathan, Van Agtmael, Tom, and Anderson, Christopher D.
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- 2021
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50. Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage.
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Falcone, Guido J., Kirsch, Elayna, Acosta, Julian N., Noche, Rommell B., Leasure, Audrey, Marini, Sandro, Chung, Jaeyoon, Selim, Magdy, Meschia, James F., Brown, Devin L., Worrall, Bradford B., Tirschwell, David L., Jagiella, Jeremiasz M., Schmidt, Helena, Jimenez‐Conde, Jordi, Fernandez‐Cadenas, Israel, Lindgren, Arne, Slowik, Agnieszka, Gill, Dipender, and Holmes, Michael
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CEREBRAL hemorrhage ,LOW density lipoproteins ,SINGLE nucleotide polymorphisms ,HIGH density lipoproteins ,INVERSE relationships (Mathematics) ,COMPARATIVE studies ,DISEASE susceptibility ,GENETIC polymorphisms ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,TRIGLYCERIDES ,EVALUATION research ,SEQUENCE analysis - Abstract
Objective: Observational studies point to an inverse correlation between low-density lipoprotein (LDL) cholesterol levels and risk of intracerebral hemorrhage (ICH), but it remains unclear whether this association is causal. We tested the hypothesis that genetically elevated LDL is associated with reduced risk of ICH.Methods: We constructed one polygenic risk score (PRS) per lipid trait (total cholesterol, LDL, high-density lipoprotein [HDL], and triglycerides) using independent genomewide significant single nucleotide polymorphisms (SNPs) for each trait. We used data from 316,428 individuals enrolled in the UK Biobank to estimate the effect of each PRS on its corresponding trait, and data from 1,286 ICH cases and 1,261 matched controls to estimate the effect of each PRS on ICH risk. We used these estimates to conduct Mendelian Randomization (MR) analyses.Results: We identified 410, 339, 393, and 317 lipid-related SNPs for total cholesterol, LDL, HDL, and triglycerides, respectively. All four PRSs were strongly associated with their corresponding trait (all p < 1.00 × 10-100 ). While one SD increase in the PRSs for total cholesterol (odds ratio [OR] = 0.92; 95% confidence interval [CI] = 0.85-0.99; p = 0.03) and LDL cholesterol (OR = 0.88; 95% CI = 0.81-0.95; p = 0.002) were inversely associated with ICH risk, no significant associations were found for HDL and triglycerides (both p > 0.05). MR analyses indicated that 1mmol/L (38.67mg/dL) increase of genetically instrumented total and LDL cholesterol were associated with 23% (OR = 0.77; 95% CI = 0.65-0.98; p = 0.03) and 41% lower risks of ICH (OR = 0.59; 95% CI = 0.42-0.82; p = 0.002), respectively.Interpretation: Genetically elevated LDL levels were associated with lower risk of ICH, providing support for a potential causal role of LDL cholesterol in ICH. ANN NEUROL 2020 ANN NEUROL 2020;88:56-66. [ABSTRACT FROM AUTHOR]- Published
- 2020
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