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2. Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling.

Author

Beck, A, Lee, C-H, Witten, D, Gleason, B, Edris, B, Espinosa, I, Zhu, S, Li, R, Montgomery, K, Marinelli, R, Tibshirani, R, Hastie, T, Jablons, David, Rubin, B, Fletcher, C, West, R, and van de Rijn, M

Subjects
Biomarkers, Tumor, Comparative Genomic Hybridization, Gene Expression Profiling, Genomics, Humans, Immunohistochemistry, Leiomyosarcoma, Prognosis, Tissue Array Analysis
Abstract

Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We used integrative molecular profiling to discover and characterize molecular subtypes of LMS. Gene expression profiling was performed on 51 LMS samples. Unsupervised clustering showed three reproducible LMS clusters. Array comparative genomic hybridization (aCGH) was performed on 20 LMS samples and showed that the molecular subtypes defined by gene expression showed distinct genomic changes. Tumors from the muscle-enriched cluster showed significantly increased copy number changes (P=0.04). A majority of the muscle-enriched cases showed loss at 16q24, which contains Fanconi anemia, complementation group A, known to have an important role in DNA repair, and loss at 1p36, which contains PRDM16, of which loss promotes muscle differentiation. Immunohistochemistry (IHC) was performed on LMS tissue microarrays (n=377) for five markers with high levels of messenger RNA in the muscle-enriched cluster (ACTG2, CASQ2, SLMAP, CFL2 and MYLK) and showed significantly correlated expression of the five proteins (all pairwise P

Published
2010

6. Risk factors and action thresholds for the novel coronavirus pandemic. Insights from the Italian Society of Nephrology COVID-19 Survey

Author

Nordio, M., Reboldi, G., Di Napoli, A., Quintaliani, G., Alberici, F., Postorino, M., Aucella, F., Messa, P., Brunori, G., Bosco, M., Malberti, F., Mandreoli, M., Mazzaferro, S., Movilli, E., Ravera, M., Salomone, M., Santoro, D., Postorinolimido, M. A., Bonomini, M., Stingone, A., Maccarone, M., Di Loreto, E., Stacchiotti, L., Malandra, R., Chiarella, S., D'Agostino, F., Fuiano, G., Nicodemo, L., Bonofiglio, R., Greco, S., Mallamaci, F., Barreca, E., Caserta, C., Bruzzese, V., Galati, D., Tramontana, D., Viscione, M., Chiuchiolo, L., Tuccillo, S., Sepe, M., Vitale, F., Ciriana, E., Martignetti, V., Caserta, D., Stizzo, A., Romano, A., Iulianiello, G., Cascone, E., Minicone, P., Chiricone, D., Delgado, G., Barbato, A., Celentano, S., Molfino, I., Coppola, S., Raiola, I., Abategiovanni, M., Borrelli, S., Margherita, C., Bruno, F., Ida, M., Aliperti, E., Potito, D., Cuomo, G., De Luca, M., Merola, M., Botta, C., Garofalo, G., Alinei, P., Paglionico, C., Roano, M., Vitale, S., Ierardi, R., Fimiani, V., Conte, G., Di Natale, G., Romano, M., Di Marino, V., Scafarto, A., Meccariello, S., Pecoraro, C., Di Stazio, E., Di Meglio, E., Cuomo, A., Maresca, B., Rotaia, E., Capasso, G., Auricchio, M., Pluvio, C., Maddalena, L., De Maio, A., Palladino, G., Buono, F., Gigliotti, G., Mancini, E., La Manna, G., Storari, A., Mosconi, G., Cappelli, G., Scarpioni, R., Gregorini, M., Rigotti, A., Mancini, W., Bianco, F., Boscutti, G., Amici, G., Tosto, M., Fini, R., Pace, G., Cioffi, A., Boccia, E., Di Lullo, L., Di Zazzo, G., Simonelli, R., Bondatti, F., Miglio, L., Rifici, N., Treglia, A., Muci, M., Baldinelli, G., Rizzi, E., Lonzi, M., De Cicco, C., Forte, F., De Paolis, P., Grandaliano, Giuseppe, Cuzziol, C., Torre, V. M., Sfregola, P., Rossi, V., Fabio, G., Flammini, A., Filippini, A., Onorato, L., Vendola, F., Di Daniela, N., Alfarone, C., Scabbia, L., Ferrazzano, M., Grotta, B. D., Gamberini, M., Fazzari, L., Mene, P., Morgia, A., Catucci, A., Palumbo, R., Puliti, M., Marinelli, R., Polito, P., Marrocco, F., Morabito, S., Rocca, R., Nazzaro, L., Lavini, R., Iamundo, V., Chiappini, M., Casarci, M., Morosetti, M., Hassan, S., Firmi, G., Galliani, M., Serraiocco, M., Feriozzi, S., Valentini, W., Sacco, P., Garibotto, G., Cappelli, V., Saffioti, C., Repetto, M., Rolla, D., Lorenz, M., Pedrini, L., Polonioli, D., Galli, E., Ruggenenti, P., Scolari, F., Bove, S., Costantino, E., Bracchi, M., Mangano, S., Depetri, G., La Milia, V., Farina, M., Zecchini, S., Savino, R., Melandri, M., Guastoni, C., Paparella, M., Gallieni, M., Minetti, E., Bisegna, S., Righetti, M., Badalamenti, S., Alberghini, E., Bertoli, S., Fabbrini, P., Albrizio, P., Rampino, T., Colturi, C., Rombola, G., Lucatello, A., Guerrini, E., Ranghino, A., Lenci, F., Fanciulli, E., Santarelli, S., Damiani, C., Garofalo, D., Sopranzi, F., Santoferrara, A., Di Luca, M., Galiotta, P., Brigante, M., Manganaro, M., Maffei, S., Berto, I., Besso, L., Viglino, G., Cusinato, S., Chiarinottichiappero, D. F., Tognarelli, G., Gianoglio, B., Forneris, G., Biancone, L., Savoldi, S., Vitale, C., Boero, R., Filiberti, O., Borzumati, M., Gesualdo, L., Lomonte, C., Gernone, G., Pallotta, G., Di Paolo, S., Vernaglione, L., Specchio, A., Stallone, G., Dell'Aquila, R., Sandri, G., Russo, F., Napoli, M., Marangi, A., Morrone, L., Di Stratis, C., Fresu, A., Cicu, F., Murtas, S., Manca, O., Pani, A., Pilloni, M., Pistis, R., Cadoni, M., Contu, B., Logias, F., Ivaldi, R., Fancello, S., Cossu, M., Lepori, G., Vittoria, S., Battiati, E., Arnone, M., Rome, M., Barbera, A., Granata, A., Collura, G., Dico, C. L., Pugliese, G., Di Natale, E., Rizzari, G., Cottone, L., Longo, N., Battaglia, G., Marcantoni, C., Giannetto, G., Tumino, G., Randazzo, F., Bellissimo, L., Faro, F. L., Grippaldi, F., Urso, S., Quattrone, G., Todaro, I., Vincenzo, D., Murgo, A., Masuzzo, M., Pisacane, A., Monardo, P., Pontorierro, M., Quari, C., Bauro, A., Chimenz, R. R., Alfio, D., Girasole, F., Cascio, A. L., Caviglia, A., Tornese, F., Sirna, F., Altieri, C., Cusumano, R., Saveriano, V., La Corte, A., Locascio, G., Rotolo, U., Musso, S., Risuglia, L., Blanco, G., Minardo, G., Castellino, S., Zappulla, Z., Randone, S., Di Francesca, M., Cassetti, C. C., Oddo, G., Buscaino, G., Mucaria, F., Barraco, V. I., Di Martino, A., Rallo, D., Dani, L., Campolo, G., Manescalchi, F., Biagini, M., Agate, M., Panichi, V., Casani, A., Traversari, L., Garosi, G., Tabbi, M., Selvi, A., Cencioni, L., Fagugli, R., Timio, F., Leveque, A., Manes, M., Mennella, G., Calo, L., Fiorini, F., Abaterusso, C., Calzavara, P., Meneghel, G., Bonesso, C., Gambaro, G., Gammaro, L., Rugiu, C., Ronco, C., Nordio M., Reboldi G., Di Napoli A., Quintaliani G., Alberici F., Postorino M., Aucella F., Messa P., Brunori G., Bosco M., Malberti F., Mandreoli M., Mazzaferro S., Movilli E., Ravera M., Salomone M., Santoro D., PostorinoLimido M.A., Bonomini M., Stingone A., Maccarone M., Di Loreto E., Stacchiotti L., Malandra R., Chiarella S., D'Agostino F., Fuiano G., Nicodemo L., Bonofiglio R., Greco S., Mallamaci F., Barreca E., Caserta C., Bruzzese V., Galati D., Tramontana D., Viscione M., Chiuchiolo L., Tuccillo S., Sepe M., Vitale F., Ciriana E., Martignetti V., Caserta D., Stizzo A., Romano A., Iulianiello G., Cascone E., Minicone P., Chiricone D., Delgado G., Barbato A., Celentano S., Molfino I., Coppola S., Raiola I., Abategiovanni M., Borrelli S., Margherita C., Bruno F., Ida M., Aliperti E., Potito D., Cuomo G., De Luca M., Merola M., Botta C., Garofalo G., Alinei P., Paglionico C., Roano M., Vitale S., Ierardi R., Fimiani V., Conte G., Di Natale G., Romano M., Di Marino V., Scafarto A., Meccariello S., Pecoraro C., Di Stazio E., Di Meglio E., Cuomo A., Maresca B., Rotaia E., Capasso G., Auricchio M., Pluvio C., Maddalena L., De Maio A., Palladino G., Buono F., Gigliotti G., Mancini E., La Manna G., Storari A., Mosconi G., Cappelli G., Scarpioni R., Gregorini M., Rigotti A., Mancini W., Bianco F., Boscutti G., Amici G., Tosto M., Fini R., Pace G., Cioffi A., Boccia E., Di Lullo L., Di Zazzo G., Simonelli R., Bondatti F., Miglio L., Rifici N., Treglia A., Muci M., Baldinelli G., Rizzi E., Lonzi M., De Cicco C., Forte F., De Paolis P., Grandaliano G., Cuzziol C., Torre V.M., Sfregola P., Rossi V., Fabio G., Flammini A., Filippini A., Onorato L., Vendola F., Di Daniela N., Alfarone C., Scabbia L., Ferrazzano M., Grotta B.D., Gamberini M., Fazzari L., Mene P., Morgia A., Catucci A., Palumbo R., Puliti M., Marinelli R., Polito P., Marrocco F., Morabito S., Rocca R., Nazzaro L., Lavini R., Iamundo V., Chiappini M., Casarci M., Morosetti M., Hassan S., Firmi G., Galliani M., Serraiocco M., Feriozzi S., Valentini W., Sacco P., Garibotto G., Cappelli V., Saffioti C., Repetto M., Rolla D., Lorenz M., Pedrini L., Polonioli D., Galli E., Ruggenenti P., Scolari F., Bove S., Costantino E., Bracchi M., Mangano S., Depetri G., La Milia V., Farina M., Zecchini S., Savino R., Melandri M., Guastoni C., Paparella M., Gallieni M., Minetti E., Bisegna S., Righetti M., Badalamenti S., Alberghini E., Bertoli S., Fabbrini P., Albrizio P., Rampino T., Colturi C., Rombola G., Lucatello A., Guerrini E., Ranghino A., Lenci F., Fanciulli E., Santarelli S., Damiani C., Garofalo D., Sopranzi F., Santoferrara A., Di Luca M., Galiotta P., Brigante M., Manganaro M., Maffei S., Berto I., Besso L., Viglino G., Cusinato S., ChiarinottiChiappero D.F., Tognarelli G., Gianoglio B., Forneris G., Biancone L., Savoldi S., Vitale C., Boero R., Filiberti O., Borzumati M., Gesualdo L., Lomonte C., Gernone G., Pallotta G., Di Paolo S., Vernaglione L., Specchio A., Stallone G., Dell'Aquila R., Sandri G., Russo F., Napoli M., Marangi A., Morrone L., Di Stratis C., Fresu A., Cicu F., Murtas S., Manca O., Pani A., Pilloni M., Pistis R., Cadoni M., Contu B., Logias F., Ivaldi R., Fancello S., Cossu M., Lepori G., Vittoria S., Battiati E., Arnone M., Rome M., Barbera A., Granata A., Collura G., Dico C.L., Pugliese G., Di Natale E., Rizzari G., Cottone L., Longo N., Battaglia G., Marcantoni C., Giannetto G., Tumino G., Randazzo F., Bellissimo L., Faro F.L., Grippaldi F., Urso S., Quattrone G., Todaro I., Vincenzo D., Murgo A., Masuzzo M., Pisacane A., Monardo P., Pontorierro M., Quari C., Bauro A., Chimenz R.R., Alfio D., Girasole F., Cascio A.L., Caviglia A., Tornese F., Sirna F., Altieri C., Cusumano R., Saveriano V., La Corte A., Locascio G., Rotolo U., Musso S., Risuglia L., Blanco G., Minardo G., Castellino S., Zappulla Z., Randone S., Di Francesca M., Cassetti C.C., Oddo G., Buscaino G., Mucaria F., Barraco V.I., Di Martino A., Rallo D., Dani L., Campolo G., Manescalchi F., Biagini M., Agate M., Panichi V., Casani A., Traversari L., Garosi G., Tabbi M., Selvi A., Cencioni L., Fagugli R., Timio F., Leveque A., Manes M., Mennella G., Calo L., Fiorini F., Abaterusso C., Calzavara P., Meneghel G., Bonesso C., Gambaro G., Gammaro L., Rugiu C., and Ronco C.

Subjects
Male, Contextual analysis, medicine.medical_treatment, Population, 030232 urology & nephrology, Recursive partitioning, 030204 cardiovascular system & hematology, Rate ratio, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Classification tree, COVID-19, Renal replacement therapy, Risk Factors, Medical, Surveys and Questionnaires, Health care, medicine, Settore MED/14 - NEFROLOGIA, Humans, education, Pandemics, Societies, Medical, Female, Italy, Nephrology, education.field_of_study, business.industry, Multilevel model, Decision rule, Confidence interval, Original Article, Hemodialysis, business, Contextual analysi, Societies, Demography
Abstract

Background and aim: Over 80% (365/454) of the nation’s centers participated in the Italian Society of Nephrology COVID-19 Survey. Out of 60,441 surveyed patients, 1368 were infected as of April 23rd, 2020. However, center-specific proportions showed substantial heterogeneity. We therefore undertook new analyses to identify explanatory factors, contextual effects, and decision rules for infection containment. Methods: We investigated fixed factors and contextual effects by multilevel modeling. Classification and Regression Tree (CART) analysis was used to develop decision rules. Results: Increased positivity among hemodialysis patients was predicted by center location [incidence rate ratio (IRR) 1.34, 95% confidence interval (CI) 1.20–1.51], positive healthcare workers (IRR 1.09, 95% CI 1.02–1.17), test-all policy (IRR 5.94, 95% CI 3.36–10.45), and infected proportion in the general population (IRR 1.002, 95% CI 1.001–1.003) (all p < 0.01). Conversely, lockdown duration exerted a protective effect (IRR 0.95, 95% CI 0.94–0.98) (p < 0.01). The province-contextual effects accounted for 10% of the total variability. Predictive factors for peritoneal dialysis and transplant cases were center location and infected proportion in the general population. Using recursive partitioning, we identified decision thresholds at general population incidence ≥ 229 per 100,000 and at ≥ 3 positive healthcare workers. Conclusions: Beyond fixed risk factors, shared with the general population, the increased and heterogeneous proportion of positive patients is related to the center’s testing policy, the number of positive patients and healthcare workers, and to contextual effects at the province level. Nephrology centers may adopt simple decision rules to strengthen containment measures timely.

Published
2021

7. Waves of infection and waves of communication: the importance of sharing in the era of Covid-19

Author

Mazzaferro, S., Rocca, A. R., Bagordo, D., Alfarone, C., Baldinelli, G., Boccia, E., Bondatti, F., Casarci, M., Catucci, A. E., Chiappini, M. G., Cioffi, A., Cuzziol, C., De Paolis, P., Della Grotta, B., Daniele, N. D., Di Lullo, L., Di Pietro, G., Di Zazzo, G., Fazzari, L., Feriozzi, S., Ferrazzano, M., Filippini, A., Fini, R., Firmi, G., Flammini, A., Forte, F., Galliani, M., Gamberini, M., Gangeri, F., Grandaliano, Giuseppe, Iamundo, V., Lavini, R., Lonzi, M., Marinelli, R., Marrocco, F., Mene, P., Miglio, L., Morabito, S., Morgia, A., Morosetti, M., Muci, M. L., Nazzaro, L., Nusca, C., Onorato, L., Pace, G., Palumbo, R., Pantano, L., Polito, P., Puliti, M., Rifici, N., Rizzi, E., Rossi, V., Sabry, H., Scabbia, L., Serraiocco, M., Sfregola, P., Simonelli, R., Treglia, A., Umbro, I., Valentini, W., Grandaliano G. (ORCID:0000-0003-1213-2177), Mazzaferro, S., Rocca, A. R., Bagordo, D., Alfarone, C., Baldinelli, G., Boccia, E., Bondatti, F., Casarci, M., Catucci, A. E., Chiappini, M. G., Cioffi, A., Cuzziol, C., De Paolis, P., Della Grotta, B., Daniele, N. D., Di Lullo, L., Di Pietro, G., Di Zazzo, G., Fazzari, L., Feriozzi, S., Ferrazzano, M., Filippini, A., Fini, R., Firmi, G., Flammini, A., Forte, F., Galliani, M., Gamberini, M., Gangeri, F., Grandaliano, Giuseppe, Iamundo, V., Lavini, R., Lonzi, M., Marinelli, R., Marrocco, F., Mene, P., Miglio, L., Morabito, S., Morgia, A., Morosetti, M., Muci, M. L., Nazzaro, L., Nusca, C., Onorato, L., Pace, G., Palumbo, R., Pantano, L., Polito, P., Puliti, M., Rifici, N., Rizzi, E., Rossi, V., Sabry, H., Scabbia, L., Serraiocco, M., Sfregola, P., Simonelli, R., Treglia, A., Umbro, I., Valentini, W., and Grandaliano G. (ORCID:0000-0003-1213-2177)

Abstract

No abstract available

Published
2021

12. Garcinoic acid prevents beta-amyloid (Abeta) deposition in the mouse brain

Author

Marinelli R, Torquato P, Bartolini D, Mas-Bargues C, Bellezza G, Gioiello A, Borras C, De Luca A, Fallarino F, Sebastiani B, Mani S, Sidoni A, Vina J, Leri M, Bucciantini M, Nardiello P, Casamenti F, and Galli F

Abstract

Garcinoic acid (GA or delta-T3-13'COOH), is a natural vitamin E metabolite that has preliminarily been identified as a modulator of nuclear receptors involved in beta-amyloid (Abeta) metabolism and progression of Alzheimer's disease (AD). In this study, we investigated GA's effects on Abeta oligomer formation and deposition. Specifically, we compared them with those of other vitamin E analogs and the soy isoflavone genistein, a natural agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) that has therapeutic potential for managing AD. GA significantly reduced Abeta aggregation and accumulation in mouse cortical astrocytes. Similarly to genistein, GA up-regulated PPARgamma expression and apolipoprotein E (ApoE) efflux in these cells with an efficacy that was comparable to that of its metabolic precursor delta-tocotrienol and higher than those of alpha-tocopherol metabolites. Unlike for genistein and the other vitamin E compounds, the GA-induced restoration of ApoE efflux was not affected by pharmacological inhibition of PPARgamma activity, and specific activation of pregnane X receptor (PXR) was observed together with ApoE and multidrug resistance protein 1 (MDR1) membrane transporter up-regulation in both the mouse astrocytes and brain tissue. These effects of GA were associated with reduced Abeta deposition in the brain of TgCRND8 mice, a transgenic AD model. In conclusion, GA holds potential for preventing Abeta oligomerization and deposition in the brain. The mechanistic aspects of GA's properties appear to be distinct from those of other vitamin E metabolites and of genistein. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

Published
2020

14. Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study

Author

Finotello, R, Vasconi, ME, Sabattini, S, Agnoli, C, Giacoboni, C, Annoni, M, Dentini, A, Bettini, G, Guazzi, P, Stefanello, D, Bottero, E, Mesto, P, Marinelli, R, De Feo, C, Marconato, L, Finotello, R., Vasconi, M.E., Sabattini, S., Agnoli, C., Giacoboni, C., Annoni, M., Dentini, A., Bettini, G., Guazzi, P., Stefanello, D., Bottero, E., Mesto, P., Marinelli, R., De Feo, C., and Marconato, L.

Subjects
Male, Lymphoma, Prognosi, Large granular lymphocyte, Cat Diseases, Prognosis, LGL, Survival Analysis, Feline, Cats, Animals, Veterinary (all), Female, Retrospective Studies
Abstract

Feline large granular lymphocyte (LGL) lymphoma is an uncommon subtype of lymphoma characterized by a grave prognosis and scarce response to chemotherapy. There are limited reports on clinico-pathological and prognostic factors. One-hundred and 9 cats with newly diagnosed LGL lymphoma that underwent initial staging (including hematology, serum biochemistry, thoracic radiographs and abdominal ultrasound), and followed-up were retrospectively evaluated. LGL lymphoma was localized within the gastrointestinal tract with or without extra-intestinal involvement in 91.7% of the cases, and at extra-gastrointestinal sites in 8.3%. Symptoms were frequent. Anemia (31.2%) and neutrophilia (26.6%) were commonly observed, and 14 (12.8%) cats had neoplastic circulating cells. Frequent biochemistry abnormalities included elevated ALT (39.4%) and hypoalbuminemia (28.4%). Twenty (54.1%) of 37 cats had elevated serum LDH. Treatment varied among cats, and included surgery (11%), chemotherapy (23%), corticosteroids (38.5%) and no treatment (27.5%). Median time to progression (MTTP) was 5 days, and median survival time (MST) 21 days. MST was significantly shorter in the case of substage b, circulating neoplastic cells, lack of chemotherapy administration, and lack of treatment response. A small subset of cats (7.3%) survived more than 6 months, suggesting that a more favorable clinical course can be found among LGL lymphoma patients.

Published
2018

19. Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study

Author

Finotello, R., primary, Vasconi, M. E., additional, Sabattini, S., additional, Agnoli, C., additional, Giacoboni, C., additional, Annoni, M., additional, Dentini, A., additional, Bettini, G., additional, Guazzi, P., additional, Stefanello, D., additional, Bottero, E., additional, Mesto, P., additional, Marinelli, R., additional, De Feo, C., additional, and Marconato, L., additional

Published
2017
Full Text
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20. Lazio dialysis registry: natives vs foreigners

Author

Di Napoli, A, Lapucci, E, Baglio, G, Di Giulio, S, Addessi, M, Alfarone, C, Amoroso, F, Apollinari, E, Baldinelli, G, Baldinelli, M, Barbera, G, Barone, P, Bartolomucci, M, Basili, A, Battista, M, Beraldi, M, Boccia, E, Bruno, F, Buono, A, Canulla, C, Capobianco, L, Caschera, M, Castellano, F, Chamoun, G, Cherubini, C, Chiappini, M, Ciano, G, Costantini, S, Cuzziol, C, Darida, S, Dascal, M, De Bella, E, De Caro, M, De Cicco, C, De Fazio, S, de Virgiliis, G, Della Grotta, F, Della Rovere, F, Di Daniele, N, Di Legge, R, Di Toro Mammarella, R, Dominijanni, S, Esposto, G, Fabozzi, G, Falcone, C, Faraglia, F, Felice, C, Felicioni, R, Feriozzi, S, Ferrari, I, Filippini, A, Fini, R, Firmi, G, Flammini, A, Floccari, F, Forte, F, Galli, D, Galliani, M, Gamberoni, M, Gargiulo, A, Giordano, N, Giustini, A, Grimaldi, R, Hassan, S, Iacono, R, Iamundo, V, Kristuli, L, Laino, M, Leoni, M, Lonzi, M, Lucchetta, F, Maggesano, V, Malaguti, M, Mangeri, M, Marinelli, A, Marinelli, R, Marsili, F, Mauro, L, Mazzaferro, S, Meconizzi, M, Melillo, F, Merigliano, V, Messia, A, Morabito, S, Morosetti, M, Murrone, P, Muzi, L, Nacca, R, Nardone, P, Naticchia, A, Nazzaro, L, Nigro, A, Noce, A, Ordonez, D, Pace, G, Palombo, R, Pantano, L, Panzieri, G, Paone, A, Paparella, M, Pasquarelli, C, Pelosi, M, Petroni, S, Picca, S, Polidori, L, Polito, P, Principe, F, Pulcinelli, G, Puliti, M, Punzo, G, Retico, E, Rifici, N, Riveruzzi, P, Rodriguez, I, Rossi, V, Rossini, B, Santoboni, A, Sfregola, P, Simeoni, P, Simonelli, R, Solazzo, A, Spagnolini, A, Spaziani, M, Splendiani, G, Staffolani, E, Startari, S, Steri, P, Sturniolo, A, Tazza, L, Torre, M, Treglia, A, Triolo, L, Tuderti, F, Tulli, U, Turchetta, L, Valentini, W, Vancini, C, Vastano, S, Vega, A, Ventola, F, Veronese, P, Villani, A, Violi, F, Vitaliano, E, Zanfoni, C, Zazzaro, D, and Zugaro, A

Subjects
Male, Survival Rate, Settore MED/14 - Nefrologia, Italy, Renal Dialysis, Emigrants and Immigrants, Humans, Female, Registries, Middle Aged, Aged
Abstract

An increasing number of foreigners was observed in Italy even among chronic dialysis patients. We compared demographic, clinical, treatment characteristics and survival probability between groups of Italian and foreign patients with chronic dialysis in Lazio.We analysed data from the Lazio Dialysis and Transplantation Registry from 2004 to 2012 (4,076 prevalent chronic dialysis patients in 31-12-2012). Among 7,970 incident patients, we evaluated, by country of birth, survival probability by using Kaplan-Meier method and mortality risk, through multiple Cox regression.We observed an increase of foreigners among chronic dialysis patients in Lazio from 2004 (4.4%) up to 2012 (7.6%, test for trend: p0,001). Compared with Italians, foreign patients were younger (53.816.3 vs. 68.713.6) and more frequently: women (42.7% vs. 37.7%), HbsAg-positive (18.1% vs. 13.9%), not vaccinated if HBV susceptible (26.8% vs. 20.9%), late referral (21.6% vs. 12.9%) and suitable for kidney transplantation (21.7% vs. 9.9%). Foreigners compared with Italians had higher survival probability at 1 year (91.9% vs. 84.7%) and 5 years (74,6% vs. 51,5%) after chronic dialysis has been started. We observed a lower mortality risk (HR=0.71;IC95%:0.58-0.87) among foreign patients even after adjustment for many potential confounding factors. Our findings suggest that health status and treatment of end stage renal disease, including access to kidney transplantation, were similar between groups of Italian and foreign patients in Lazio. Observed differences in patients' characteristics were probably attributable to younger age of foreigners. However, further analyses are needed to fully explain higher survival probability in chronic dialysis among foreigners compared with Italians.

Published
2015

21. Suscettibilità ipnotica e linguaggio

Author

Marinelli R., Bindi R., Marchi S., Santarcangelo E. L., Cavallaro F., Castellani E., and Carli G.

Subjects
ipnosi, linguaggio, nlp
Published
2012

23. Suscettibilità ipnotica e linguaggio

Author

Marinelli, R., Remo Bindi, R., Simone Marchi, S., Santarcangelo, ENRICA LAURA, Cavallaro, Fi, and Castellani E., Carli G.

Published
2011

24. Ontological variation and sense extension in proper names

Author

Marinelli R.

Subjects
cognitive linguistics, metonymy, lexical semantic databases, metaphor, proper names
Abstract

The lexical coverage of the semantic database ItalWordNet has been extended by adding to the first nucleus of nouns and verbs, a set of adjectives and adverbs and also a set of Proper Names (PNs). Particular cases of polysemy were found in codifying PNs. Sense variation in PNs was verified in linguistic resources and new semantic relations were created in order to represent the sense extension phenomenon in the database. The relationship between the PNs present in IWN and the ontological classification of their belonging classes was highlighted: correspondence between sense variations and ontological variations was examined and the reference to the ontological structure of IWN was of help in recognizing many cases of PNs sense extension.

Published
2010

25. Il modello semantico di EuroWordNet come strumento per la strutturazione della relazione associativa nei thesauri

Author

Marinelli R., Mazzocchi F., Tiberi M., and Motta M.

Subjects
database semantico-lessicali, relazione associativa, terminologia, thesauri, risorse linguistiche
Abstract

Thesauri are tools which semantically organize a domain of knowledge for operational purposes. Their relational semantics is concerned with methods that connect terms with related meanings and it is important to support information retrieval, enhancing the information recall performance and contributing to improve precision. In fact, the network of relations of a thesaurus has an important semantic function, providing a representation of the meaning of each thesaurus term and a map of the conceptual structure of a subject area. The traditional thesaurus format - as described in international standards - includes the hierarchical, associative and equivalence relationships. However, a rather widespread opinion is that this format should be refined, in order to cope with the current needs of information organization. This paper discusses the possibility of refining the associative relation into a number of sub-kinds by adopting the semantic model of EuroWordNet (EWN), as it was used, according to one of its national versions, ItalWordNet (IWN), taking into account the terminological database Mariterm, which contains terms belonging to the maritime domain. It is also stressed how RT designation and refinement appear to be domain dependent, in the sense that they are associated with the specific features of a knowledge field.

Published
2010

26. Adding information to a terminological database by means of image files

Author

Marinelli R., Spadoni G., and Cucurullo S.

Subjects
terminology, computational resources, lexical databases, images
Abstract

A lexical semantic database containing terms belonging to the specialized lexicon of the maritime navigation and maritime transport was built according to WordNet/EuroWordNet model. Our paper present a project planning the enrichment of the terminological database by means of a set of images. A short description is given about a) the structure of the terminological database and the domain conceptual modelling; b) the various features of the database management tool, and, among all, the possibility of visualizing, on demand, the image which is associated with the term being sought, contributing to clarify and refine the meaning of the term, increasing its information and communication effectiveness.

Published
2010

27. Lexical Resources and Ontological Classifications for the Recognition of Proper Names Sense Extension

Author

Marinelli R.

Subjects
Lexical Database, Corpus creation and annotation, Ontologies, Lexicon
Abstract

Particular uses of PNs with sense extension are focussed on and inspected taking into account the presence of PNs in lexical semantic databases and electronic corpora. Methodology to select ad include PNs in semantic databases is described; the use of PNs in corpora of Italian Language is examined and evaluated, analyzing the behaviour of a set of PNs in different periods of time. Computational resources can facilitate our study in this field in an effective way by helping codify, translate and handle particular cases of polysemy, but also guiding in metaphorical and metonymic sense recognition, supported by the ontological classification of the lexical semantic entities. The relationship between the "abstract" and the "concrete", which is at the basis of the Conceptual Metaphor perspective, can be considered strictly related to the variation of the ontological values found in our analysis of the PNs and their belonging classes which are codified in the ItalWordNet database.

Published
2010

30. Lexical Semantic Resources in a Terminological Network

Author

Marinelli R., Roventini A., Spadoni G., and Cucurullo S.

Subjects
Lexical database, Ontologies, Lexicon, Semantics
Abstract

A research has been carried on and is still in progress aimed at the construction of three specialized lexicons organized as databases of relational type. The three databases contain terms belonging to the specialized knowledge fields of maritime terminology (technical-nautical and maritime transport domain), taxation law, and labour law with union labour rules, respectively. The EuroWordNet/ItalWordNet model was firstly used to structure the terminological database of maritime domain. The methodology experimented for its construction was applied to construct the next databases. It consists in i) the management of corpora of specialized languages and ii) the use of generic databases to identify and extract a set of candidate terms to be codified in the terminological databases. The three specialized resources are described highlighting the various kinds of lexical semantic relations linking each term to the others within the single terminological database and to the generic resources WordNet and ItalWordNet. The construction of these specialized lexicons was carried on in the framework of different projects; but they can be seen as a first nucleus of an organized network of generic and specialized lexicons with the purpose of making the meaning of each term clearer from a cognitive point of view.

Published
2010

31. Visual information to improve a lexical-semantic terminological resource

Author

Marinelli R., Spadoni G., and Cucurullo S.

Subjects
Lexical Semantic Data Bases, computational resources, Visual Information, terminological databases, Terminology
Abstract

The lexical semantic database MariTerm contains structured information about the specialized terminology of the maritime domain (maritime navigation and transport). This paper describes the main phases of a project which aims to enhance the terminological database by means of a set of images: a) the structure of the terminological database; b) the domain conceptual modelling; c) the database management tool which, among its various features, allows visualization on demand of the image which is associated with the term being sought, contributing to clarification of the meaning of the term and increasing its information and communication potential.

Published
2009

34. Refining the thesaural associative relationship by applying the EuroWordnet semantic model

Author

Mazzocchi F., Marinelli R., and Tiberi M.

Subjects
thesaurus, lexical database, semantic relations
Abstract

Thesauri are tools which semantically organize a domain of knowledge for operational purposes. Their relational semantics is concerned with methods that connect terms with related meanings and are designed to support information retrieval, namely enhancing the information recall performance and contributing to improve precision, too. The network of relations of a thesaurus has a semantic function: by means of it, in fact, a representation of the meaning of each thesaurus term is provided, as well as of the conceptual structure of a subject area. The traditional thesaurus format - as described in international standards - includes three basic relationships, two of them at a conceptual level, hierarchical and associative relations, the other mostly at a lexical level, relation of equivalence. However, a rather widespread opinion is that this format should be refined in order to cope with the current needs of information organization. This refinement is necessary to enhance thesaurus suitability for uses in artificial intelligence (AI) and in the Semantic Web environments, as well as to increase possibilities for IR. This paper discusses the possibility of refining the associative relation into a number of sub-kinds by adopting the semantic model of EuroWordNet (EWN), as it was used, according to one of its national versions, ItalWordNet (IWN), to structure a terminological resource for a specific domain. A number of issues that such a work of refinement could imply, and in particular its domain dependence, are also discussed.

Published
2008

36. Ontological Structure and Digital Corpora for Metaphorical Sense Recognition

Author

Marinelli R.

Subjects
Corpora, Metaphorical sense recognition, Ontology, Figurative language, Terminology
Abstract

Based on the EuroWordNet/ItalWordNet model, a terminological database which contains terms belonging to the specialized lexicon of the maritime navigation and transport domain was created. Our lexicographic research aims to give prominence to the frequency of idiomatic expressions and metaphors used in everyday language that come from this cultural environment. This paper deals with a) idiomatic expressions and metaphors of the maritime domain which is considered as "source" domain, b) the use and the frequency of this type of idiomatic expressions and metaphors in a large corpus of Italian contemporary language, c) the semantic codification of metaphors and idiomatic expressions in the terminological database, d) the way the ontological structure of the database can help in metaphorical sense recognition.

Published
2008

40. Language modulation by hypnotizability

Author

Carli, G., Marinelli, R., Bindi, R., Marchi, S., Cavallaro, F. I., Castellani, E., and Santarcangelo, ENRICA LAURA

Subjects
Psychotherapy, Neurorehabilitation
Published
2008

45. Modeling a Maritime Domain Ontology

Author

Marinelli R. and Spadoni G.

Subjects
terminology, computational resources, lexical databases, ontology
Abstract

The users' demand has determined the need to manage the growing new technical maritime terminology which includes very different domains such as the juridical or commercial ones. A terminological database was built by exploiting the computational tools of ItalWordNet (IWN) and its lexical-semantic model EuroWordNet. This paper concerns the development of database structure and data coding, relevance of the concepts of 'term' and 'domain', information potential of the terms, complexity of this domain and detailed ontology structuring recently undertaken and still in progress. Our domain structure is described defining a core set of terms representing the two main sub-domains specified in 'technical-nautical' and 'maritime transport' terminology. These terms are sufficiently general to be the root nodes of the core ontology we are developing. They are mostly domain-dependent, but the link with the Top Ontology of IWN remains, endorsing either general and 'foundation' information, or detailed description directly connected with the specific domain. This structure seems to be the most appropriate to characterize the main conceptual schemas that people of the technical-nautical or maritime transport "world" actually use, namely activity plans, navigation management, etc. Also a set of acronyms has been codified to represent their ever increasing use in maritime terminology. Through the semantic relations linking the synsets, every term 'inherits' the IWN Top Ontology definitions and becomes itself an integral part of the structure. While codifying a term in the maritime database, the reference is at the same time allowed to the Base Concepts of the terminological ontology embedding the term in the semantic network, showing that upper and core ontologies make it possible for the framework to integrate different views on the same domain in a meaningful way.

Published
2007

50. The Italian Marittime Lexicon and the ItalWordNet Semantic Database

Author

Marinelli R. and Roventini A.

Subjects
Ontology, Lexical databases, Terminology
Abstract

The paper reports on the creation of a terminological subset belonging to the maritime lexical domain; this set of terms is structured according to the design principles of the generic Italian lexical semantic database ItalWordNet, i.e. applying the same semantic relations model and using the possibility of linking the specialised terms to the corresponding closest concepts in WordNet. The main characteristics of the lexical semantic database are also described and, in particular: i) the construction of the terminological wordnet; ii) the approach adopted to connect the terminological database to the generic one; iii) some issues about the mapping between the Italian terms and the Princeton WordNet; iv) a first outline of a specific maritime domain ontology.

Published
2006

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