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Introduction. Tenofovir is an antiviral drug of the group of nucleoside reverse transcriptase inhibitors of retrovirus - human immunodeficiency virus. Material and methods. A toxicological and hygienic study of the toxicity and danger of tenofovir in laboratory animals (mice, rats, rabbits) was carried out with various routes of intake: orally (mice, rats), intraperitoneally (mice), cutaneous (mice, rabbits), inhalation (rats) for development and justification of indicative limit values of tenofovir in the air of the working area. Results. When injected into the stomach, tenofovir belongs to the 4th hazard class in terms of DL50 for mice and rats over 10,000 mg/kg (GOST 12.1.007-76). When injected into the abdominal cavity DL50 for male mice 1443 mg/kg (OECD toxicity class 5). Tenofovir has a moderate irritant effect on the mucous membranes of the eyes of rabbits, does not irritate the skin; does not have a skin-resorptive, cumulative and sensitizing effect. In a subacute experiment in rats with intragastric administration (1000 mg/kg, 28 days), tenofovir had a general toxic effect with a predominant impairment of kidney and liver function. Tenofovir Limac is set at 17.3 mg/m3 for effects on renal function. Limitations. When developing and substantiating hygienic standards for the anti-retroviral drug tenofovir in the air of the working area. Conclusion. The recommended indicative limit values for tenofovir disoproxil fumarate aerosol in the air of the working area is 0.1 mg/m3.

Has been made an assessment of the toxicity of residual amounts of disinfectants after using them on products, made from various materials, with DS solutions based on QAC. The working solutions were used in concentrations from 0.3 to 7 % (by DV). The safety of the studied samples was assessed by the toxicity index "It" (in%) on an AT-05 Image Analyzer. Washing out of the residual amounts of DS in concentrations of 0.3–0.7 % (by DW) did not significantly affect the total time of disinfection treatment or pre-sterilization cleaning. At higher concentrations of solutions, there were differences in the time of washing test items and dishes for receiving safe amounts of DS. It is concluded that it is inexpedient to use solutions based on QAC in a concentration of more than 4.5 % (in terms of DV) for disinfection treatment and pre-sterilization cleaning of products made of natural and silicone rubber. Keywords: disinfectants, quaternary ammonium compounds, product washing, AT-05 image analyzer, to­xicity index.

Introduction. The study’s relevance is due to the demand for repellent and insecticidal agents in the consumer market and their widespread use as protection against mosquitoes. At the same time, the problem of the impact on the human health of these funds has not been sufficiently studied. In this regard, analyzing the safety of repellents and insecticides for human health is of scientific interest. The aim of the study is to substantiate methodological approaches to assessing the risk to human health associated with the use of insecticides and repellents. Materials and methods. Authors used methods of analysis of scientific literature, toxicological methods for the study of health safety, methods of quantitative chemical analysis, biochemical methods for the study of blood serum, methods of mathematical modeling, health risk assessment methodology. Results. The assessment of the risk of negative responses from organs and systems of the body when exposed to repellents and insecticides has been carried out. Methodological approaches to assessing health risks under various scenarios for repellents and insecticides have been developed and tested. Conclusion. A feature of the proposed methodological approaches is the ability to take into account dose loads for various routes of entry of active substances into the body, the duration of exposure to a repellent or insecticide during regular use, and possible use in regimes exceeding normal use. As a result of the experiment, it was found that with the inhalation of an insecticide with 1% transfluthrin, the level of acceptable risk is observed at a level of exposure of transfluthrin in the air up to 0.0272 mg/m 3 . Under a percutaneous intake of the 50% DEET repellent, the acceptable risk level was noted at exposure less than 1200 mg/kg/day. In case of percutaneous arrival of the DETA repellent 7.5%, the level of acceptable risk is established under exposure up to 250 mg/kg/day.

InVitro laboratory has investigated and made comparative analysis of irritant effect of disinfectants on rabbits. Main active substances of studied skin antiseptics were: alcohols, chlorhexidine bigluconate, alkyldime­thylbenzylammonium chloride, didecyldimethylammonium chloride, N,N-bis(3-aminopropyl)dodecylamine. Has been developed method for evaluating the irritant effect of skin antiseptics on bull sperm suspensions.

Introduction. As household insecticidal agents for mosquito control, electric fumigators are used complete with plates and/or liquid, which can pose an inhalation hazard during work. Material and methods. The toxicity and danger of five samples of electrofumigators on the basis of transfluthrin and prallethrin in the form of liquid and plates were studied. Two modes of application of electric fumigators have been tested: with 30-minutes airing after an hour-long treatment and further stay in the room of people and with the continuous operation of the electric fumigator in a ventilated room in the presence of people. High-performance liquid chromatography was used to determine the active substances in the air; the sensitivity of the method was 0.001 mg / m3. The assessment of the acute inhalation hazard of volatile components released during the operation of the electric fumigator was carried out on white outbred rats. Results. The obtained data showed that when using electric fumigators on transfluthrin and prallethrin, they are observed to increase in the air as compared with the hygienic standards established for them for the atmospheric air of populated areas. The research results depended on the form of the product and the chosen mode of application. Thus, assessing the first mode of application of the plates on transfluthrin, it was revealed that 30 minutes of airing the room is not enough, the excess of environmental tentative safe exposure levels was recorded. The study of the second mode of application of fluid and plates on transfluthrin revealed a tendency to increase its content in the air of the treated room when using both forms. When using the second mode of application of the liquid and the plates on prallethrin, it that after 1 h of operation of the electrofumigator with liquid, the concentration of prallethrin significantly was revealed to exceed the hygienic standard. Conclusion. The use of electrofumigators working for 8 hours in the presence of people is not recommended for use, it is necessary to ventilate the room when the fumigator is in operation for more than 1 hour.