1. Inflammation biomarkers in OSA, chronic obstructive pulmonary disease, and chronic obstructive pulmonary disease/OSA overlap syndrome.
- Author
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Sanchez-Azofra, Ana, Gu, Wanjun, Masso-Silva, Jorge A, Sanz-Rubio, David, Marin-Oto, Marta, Cubero, Pablo, Gil, Ana V, Moya, Esteban A, Barnes, Laura A, Mesarwi, Omar A, Marin, Traci, Simonson, Tatum S, Crotty Alexander, Laura E, Marin, Jose M, and Malhotra, Atul
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Cardiovascular ,Clinical Research ,Chronic Obstructive Pulmonary Disease ,Prevention ,Sleep Research ,Lung ,2.1 Biological and endogenous factors ,Respiratory ,Good Health and Well Being ,Humans ,C-Reactive Protein ,Interleukin-6 ,Sleep Apnea ,Obstructive ,Sleep Apnea Syndromes ,Pulmonary Disease ,Chronic Obstructive ,Inflammation ,Biomarkers ,Autoimmune Diseases ,Granulocyte Colony-Stimulating Factor ,cardiovascular risk ,sleep-disordered breathing ,obstructive sleep apnea ,chronic obstructive pulmonary disease ,overlap syndrome ,c-reactive protein ,granulocyte colony stimulating factor ,interleukin 6 ,interleukin 8 ,Clinical Sciences ,Other Medical and Health Sciences ,Psychology ,Neurology & Neurosurgery ,Clinical sciences - Abstract
Study objectivesThe coexistence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) in a single individual, also known as overlap syndrome (OVS), is associated with higher cardiovascular risk and mortality than either OSA or COPD alone. However, the underlying mechanisms remain unclear. We hypothesized that patients with OVS have elevated systemic inflammatory biomarkers relative to patients with either disease alone, which could explain greater cardiovascular risk observed in OVS.MethodsWe included 255 participants in the study, 55 with COPD alone, 100 with OSA alone, 50 with OVS, and 50 healthy controls. All participants underwent a home sleep study, spirometry, and a blood draw for high-sensitivity C-reactive protein and total blood count analysis. In a randomly selected subset of 186 participants, inflammatory protein profiling was performed using Bio-Rad Bio-Plex Pro Human Cytokine 27-Plex Assays. Biomarker level differences across groups were identified using a mixed linear model.ResultsLevels of interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and granulocyte colony stimulating factor (G-CSF) were higher in participants with OVS and COPD compared with healthy controls and participants with OSA. Furthermore, participants with OVS had higher circulating levels of leukocytes and neutrophils than those with COPD, OSA, and controls.ConclusionsCOPD and OVS are associated with higher systemic inflammation relative to OSA and healthy controls. This work proposes the potential utilization of interleukin 6, granulocyte colony stimulating factor, and high-sensitivity C-reactive protein as screening biomarkers for COPD in patients with OSA. Inflammatory pathways may not fully explain the higher cardiovascular risk observed in OVS, indicating the need for further investigation.CitationSanchez-Azofra A, Gu W, Masso-Silva JA, et al. Inflammation biomarkers in OSA, chronic obstructive pulmonary disease, and chronic obstructive pulmonary disease/OSA overlap syndrome. J Clin Sleep Med. 2023;19(8):1447-1456.
- Published
- 2023