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161 results on '"Marijnen, C. A. M."'

1. Neoadjuvant FOLFOXIRI prior to chemoradiotherapy for high-risk (“ugly”) locally advanced rectal cancer: study protocol of a single-arm, multicentre, open-label, phase II trial (MEND-IT)

Author

van den Berg, K., Schaap, D. P., Voogt, E. L. K., Buffart, T. E., Verheul, H. M. W., de Groot, J. W. B., Verhoef, C., Melenhorst, J., Roodhart, J. M. L., de Wilt, J. H. W., van Westreenen, H. L., Aalbers, A. G. J., van ‘t Veer, M., Marijnen, C. A. M., Vincent, J., Simkens, L. H. J., Peters, N. A. J. B., Berbée, M., Werter, I. M., Snaebjornsson, P., Peulen, H. M. U., van Lijnschoten, I. G., Roef, M. J., Nieuwenhuijzen, G. A. P., Bloemen, J. G., Willems, J. M. W. E., Creemers, G. J. M., Nederend, J., Rutten, H. J. T., and Burger, J. W. A.

Published
2022
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2. Tumoren van dunne en dikke darm

Author

Tanis, P. J., Beets-Tan, R. G. H., Marijnen, C. A. M., Nagtegaal, I. D., Koopman, M., Bol, G. M., van Krieken, J.H.J.M., editor, Beets-Tan, R.G.H., editor, Gelderblom, A.J., editor, Olofsen, M.J.J., editor, and Rutten, H.J.T., editor

Published
2020
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3. Evolution of clinical nature, treatment and survival of locally recurrent rectal cancer: Comparative analysis of two national cross-sectional cohorts

Author

Cancer, MS Radiotherapie, van Geffen, E G M, Langhout, J M A, Hazen, S J A, Sluckin, T C, van Dieren, S, Beets, G L, Beets-Tan, R G H, Borstlap, W A A, Burger, J W A, Horsthuis, K, Intven, M P W, Aalbers, A G J, Havenga, K, Marinelli, A W K S, Melenhorst, J, Nederend, J, Peulen, H M U, Rutten, H J T, Schreurs, W H, Tuynman, J B, Verhoef, C, de Wilt, J H W, Marijnen, C A M, Tanis, P J, Kusters, M, On Behalf Of The Dutch Snapshot Research Group, Cancer, MS Radiotherapie, van Geffen, E G M, Langhout, J M A, Hazen, S J A, Sluckin, T C, van Dieren, S, Beets, G L, Beets-Tan, R G H, Borstlap, W A A, Burger, J W A, Horsthuis, K, Intven, M P W, Aalbers, A G J, Havenga, K, Marinelli, A W K S, Melenhorst, J, Nederend, J, Peulen, H M U, Rutten, H J T, Schreurs, W H, Tuynman, J B, Verhoef, C, de Wilt, J H W, Marijnen, C A M, Tanis, P J, Kusters, M, and On Behalf Of The Dutch Snapshot Research Group

Published
2024

4. Tumoren van dunne en dikke darm

Author

Tanis, P. J., Beets-Tan, R. G. H., Marijnen, C. A. M., Nagtegaal, I. D., Punt, C. J. A., van de Velde, C.J.H., editor, van der Graaf, W.T.A., editor, van Krieken, J.H.J.M., editor, and Marijnen, C.A.M., editor

Published
2017
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5. The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancerdresults from the RAPIDO trial

Author

Dijkstra, E. A., Zwart, W. H., Nilsson, P. J., Putter, H., Roodvoets, A. G. H., Kranenbarg, E. Meershoek-Klein, Froedin, J. E., Nygren, Peter, ostergaard, L., Kersten, C., Verbiene, I., Cervantes, A., Hendriks, M. P., Capdevila, J., Edhemovic, I., van de Velde, C. J. H., Marijnen, C. A. M., van Etten, B., Hospers, G. A. P., Glimelius, Bengt, Dijkstra, E. A., Zwart, W. H., Nilsson, P. J., Putter, H., Roodvoets, A. G. H., Kranenbarg, E. Meershoek-Klein, Froedin, J. E., Nygren, Peter, ostergaard, L., Kersten, C., Verbiene, I., Cervantes, A., Hendriks, M. P., Capdevila, J., Edhemovic, I., van de Velde, C. J. H., Marijnen, C. A. M., van Etten, B., Hospers, G. A. P., and Glimelius, Bengt

Abstract

Background: Pre-operative chemoradiotherapy (CRT) rather than radiotherapy (RT) has resulted in fewer locoregional recurrences (LRRs), but no decrease in distant metastasis (DM) rate for patients with locally advanced rectal cancer (LARC). In many countries, patients receive post-operative chemotherapy (pCT) to improve oncological outcomes. We investigated the value of pCT after pre-operative CRT in the RAPIDO trial. Patients and methods: Patients were randomised between experimental (short-course RT, chemotherapy and surgery) and standard-of-care treatment (CRT, surgery and pCT depending on hospital policy). In this substudy, we compared curatively resected patients from the standard-of-care group who received pCT (pCT+ group) with those who did not (pCT- group). Subsequently, patients from the pCT+ group who received at least 75% of the prescribed chemotherapy cycles (pCT >75% group) were compared with patients who did not receive pCT (pCT-/- group). By propensity score stratification (PSS), we adjusted for the following unbalanced confounders: age, clinical extramural vascular invasion, distance to the anal verge, ypT stage, ypN stage, residual tumour, serious adverse event (SAE) and/or readmission within 6 weeks after surgery and SAE related to pre-operative CRT. Cumulative probability of disease-free survival (DFS), DM, LRR and overall survival (OS) was analysed by Cox regression. Results: In total, 396/452 patients had a curative resection. The number of patients in the pCT+, pCT >75%, pCT- and pCT-/- groups was 184, 112, 154 and 149, respectively. The PSS-adjusted analyses for all endpoints demonstrated hazard ratios between approximately 0.7 and 0.8 (pCT+ versus pCT-), and 0.5 and 0.8 (pCT >75% versus pCT-/-). However, all 95% confidence intervals included 1. Conclusions: These data suggest a benefit of pCT after pre-operative CRT for patients with high-risk LARC, with approximately 20%-25% improvement in DFS and OS and 20%-25% risk reductions in DM

Published
2023
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6. Authors' reply-A sensitivity analysis of the RAPIDO clinical trial

Author

Dijkstra, E. A., Zwart, W. H., Putter, H., Marijnen, C. A. M., Nilsson, P. J., van de Velde, C. J. H., van Etten, B., Hospers, G. A. P., Glimelius, Bengt, Dijkstra, E. A., Zwart, W. H., Putter, H., Marijnen, C. A. M., Nilsson, P. J., van de Velde, C. J. H., van Etten, B., Hospers, G. A. P., and Glimelius, Bengt

Published
2023
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8. The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancer-results from the RAPIDO trial

Author

Dijkstra, E A, Zwart, W H, Nilsson, P J, Putter, H, Roodvoets, A G H, Meershoek-Klein Kranenbarg, E, Frödin, J E, Nygren, P, Østergaard, L, Kersten, C, Verbiené, I, Cervantes, A, Hendriks, M P, Capdevila, J, Edhemovic, I, van de Velde, C J H, Marijnen, C A M, van Etten, B, Hospers, G A P, Glimelius, B, and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
post-operative chemotherapy, Cancer Research, oncological outcomes, propensity score stratification, Neoadjuvant Therapy/methods, Rectal Neoplasms/drug therapy, Infant, Disease-Free Survival, Chemoradiotherapy/methods, adjuvant chemotherapy, Neoplasm Recurrence, Local/drug therapy, Oncology, locally advanced rectal cancer, Humans
Abstract

BACKGROUND: Pre-operative chemoradiotherapy (CRT) rather than radiotherapy (RT) has resulted in fewer locoregional recurrences (LRRs), but no decrease in distant metastasis (DM) rate for patients with locally advanced rectal cancer (LARC). In many countries, patients receive post-operative chemotherapy (pCT) to improve oncological outcomes. We investigated the value of pCT after pre-operative CRT in the RAPIDO trial.PATIENTS AND METHODS: Patients were randomised between experimental (short-course RT, chemotherapy and surgery) and standard-of-care treatment (CRT, surgery and pCT depending on hospital policy). In this substudy, we compared curatively resected patients from the standard-of-care group who received pCT (pCT+ group) with those who did not (pCT- group). Subsequently, patients from the pCT+ group who received at least 75% of the prescribed chemotherapy cycles (pCT ≥75% group) were compared with patients who did not receive pCT (pCT-/- group). By propensity score stratification (PSS), we adjusted for the following unbalanced confounders: age, clinical extramural vascular invasion, distance to the anal verge, ypT stage, ypN stage, residual tumour, serious adverse event (SAE) and/or readmission within 6 weeks after surgery and SAE related to pre-operative CRT. Cumulative probability of disease-free survival (DFS), DM, LRR and overall survival (OS) was analysed by Cox regression.RESULTS: In total, 396/452 patients had a curative resection. The number of patients in the pCT+, pCT >75%, pCT- and pCT-/- groups was 184, 112, 154 and 149, respectively. The PSS-adjusted analyses for all endpoints demonstrated hazard ratios between approximately 0.7 and 0.8 (pCT+ versus pCT-), and 0.5 and 0.8 (pCT ≥75% versus pCT-/-). However, all 95% confidence intervals included 1.CONCLUSIONS: These data suggest a benefit of pCT after pre-operative CRT for patients with high-risk LARC, with approximately 20%-25% improvement in DFS and OS and 20%-25% risk reductions in DM and LRR. Compliance with pCT additionally reduces or improves all endpoints by 10%-20%. However, differences are not statistically significant.

Published
2023
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10. Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo)radiotherapy and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) randomized phase III trial†

Author

Breugom, A. J., van Gijn, W., Muller, E. W., Berglund, Å., van den Broek, C. B. M., Fokstuen, T., Gelderblom, H., Kapiteijn, E., Leer, J. W. H., Marijnen, C. A. M., Martijn, H., Meershoek-Klein Kranenbarg, E., Nagtegaal, I. D., Påhlman, L., Punt, C. J. A., Putter, H., Roodvoets, A. G. H., Rutten, H. J. T., Steup, W. H., Glimelius, B., and van de Velde, C. J. H.

Published
2015
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12. International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic

Author

Marijnen, C. A. M., Peters, F. P., Roedel, C., Bujko, K., Haustermans, K., Fokas, E., Glynne-Jones, R., Valentini, V., Spindler, K. -LG., Guren, M. G., Maingon, Philippe, Calvo, F. A., Pares, O., Glimelius, Bengt, Sebag-Montefiore, D., Marijnen, C. A. M., Peters, F. P., Roedel, C., Bujko, K., Haustermans, K., Fokas, E., Glynne-Jones, R., Valentini, V., Spindler, K. -LG., Guren, M. G., Maingon, Philippe, Calvo, F. A., Pares, O., Glimelius, Bengt, and Sebag-Montefiore, D.

Published
2020
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23. Radiotherapy quality assurance program for the STAR-TReC trial; planning results of Dutch centers

Author

MMB Research line 1, PMC Medisch specialisten, MS Radiotherapie, Cancer, Klinische Fysica RT, Circulatory Health, Arts Assistenten Cardiologie, Peters, F. P., Kerkhof, E. M., Rutten, H., Intven, M., Berbee, M., Theuws, J., Van Triest, B., Reerink, O., Rozema, T., Van Leeuwen, R. H. G., Tijssen, R. N. H., Van den Boogaard, J., Murrer, L., Van Haaren, P., Van der Heide, U. A., Stoian, G., Jansen, R., Raaijmakers, E., Van Weerd, E., Marijnen, C. A. M., MMB Research line 1, PMC Medisch specialisten, MS Radiotherapie, Cancer, Klinische Fysica RT, Circulatory Health, Arts Assistenten Cardiologie, Peters, F. P., Kerkhof, E. M., Rutten, H., Intven, M., Berbee, M., Theuws, J., Van Triest, B., Reerink, O., Rozema, T., Van Leeuwen, R. H. G., Tijssen, R. N. H., Van den Boogaard, J., Murrer, L., Van Haaren, P., Van der Heide, U. A., Stoian, G., Jansen, R., Raaijmakers, E., Van Weerd, E., and Marijnen, C. A. M.

Published
2018

24. Tumoren van de urinewegen

Author

van Moorselaar, R. J. A., Hulshof, M. C. C. M., van Leenders, G. J. L. H., Gerritsen, W. R., van Poppel, H., Van de Velde, C. J. H., Van der Graaf, W. T. A., Van Krieken, J. H. J. M., Marijnen, C. A. M., CCA - Treatment and quality of life, Radiotherapy, and Cancer Center Amsterdam

Published
2017

25. Tumoren van het zenuwstelsel

Author

Dirven, C. M. F., van den Bent, M. J., Stalpers, Lukas J. A., Van de Velde, C. J. H., Van der Graaf, W. T. A., Van Krieken, J. H. J. M., Marijnen, C. A. M., APH - Methodology, CCA - Treatment and quality of life, Radiotherapy, and Cancer Center Amsterdam

Published
2017

26. MRI cT1–2 rectal cancer staging accuracy: a population‐based study.

Author

Detering, R., Oostendorp, S. E., Meyer, V. M., Dieren, S., Bos, A. C. R. K., Dekker, J. W. T., Reerink, O., Waesberghe, J. H. T. M., Marijnen, C. A. M., Moons, L. M. G., Beets‐Tan, R. G. H., Hompes, R., Westreenen, H. L., Tanis, P. J., and Tuynman, J. B.

Subjects
RECTAL cancer, TUMOR classification, ENDORECTAL ultrasonography, SURGICAL excision, RECTAL surgery
Abstract

Copyright of British Journal of Surgery is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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27. Acute toxicity of intraoperative radiotherapy and external beam-accelerated partial breast irradiation in elderly breast cancer patients

Author

Jacobs, D. H. M., primary, Speijer, G., additional, Petoukhova, A. L., additional, Roeloffzen, E. M. A., additional, Straver, M., additional, Marinelli, A., additional, Fisscher, U., additional, Zwanenburg, A. G., additional, Merkus, J., additional, Marijnen, C. A. M., additional, Mast, M. E., additional, and Koper, P. C. M., additional

Published
2018
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29. A multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer

Author

Borstlap, W. A. A., primary, Tanis, P. J., additional, Koedam, T. W. A., additional, Marijnen, C. A. M., additional, Cunningham, C., additional, Dekker, E., additional, van Leerdam, M. E., additional, Meijer, G., additional, van Grieken, N., additional, Nagtegaal, I. D., additional, Punt, C. J. A., additional, Dijkgraaf, M. G. W., additional, De Wilt, J. H., additional, Beets, G., additional, de Graaf, E. J., additional, van Geloven, A. A. W, additional, Gerhards, M. F., additional, van Westreenen, H. L., additional, van de Ven, A. W. H., additional, van Duijvendijk, P., additional, de Hingh, I. H. J. T., additional, Leijtens, J. W. A., additional, Sietses, C., additional, Spillenaar-Bilgen, E. J., additional, Vuylsteke, R. J. C. L. M., additional, Hoff, C., additional, Burger, J. W. A., additional, van Grevenstein, W. M. U., additional, Pronk, A., additional, Bosker, R. J. I., additional, Prins, H., additional, Smits, A. B., additional, Bruin, S., additional, Zimmerman, D. D., additional, Stassen, L. P. S., additional, Dunker, M. S., additional, Westerterp, M., additional, Coene, P. P., additional, Stoot, J., additional, Bemelman, W. A., additional, and Tuynman, J. B., additional

Published
2016
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32. De pathogenese van dikkedarmkanker

Author

Vermeulen, L., Medema, J. P., Punt, C. J. A., Marijnen, C. A. M., Nagtegaal, I. D., van de Velde, C. J. H., Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Center of Experimental and Molecular Medicine, and Radiotherapy

Published
2013

38. Handboek colorectaal carcinoom

Author

Punt, C. J. A., Marijnen, C. A. M., Nagtegaal, I. D., van de Velde, C. J. H., Cancer Center Amsterdam, and Oncology

Published
2013

41. Risk factors for non-radical resection, local recurrence, disease free survival and overall survival for rectal cancer in EORTC 22921 trial

Author

Den Dulk , M., Collette , L., Van De Velde , C. J. H., Marijnen , C. A. M., Bosset , J. F., Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), and Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon )

Subjects
[SDV.CAN]Life Sciences [q-bio]/Cancer, [ SDV.CAN ] Life Sciences [q-bio]/Cancer
Published
2006

48. Decision consultations on preoperative radiotherapy for rectal cancer: large variation in benefits and harms that are addressed.

Author

Kunneman, M, Marijnen, C A M, Rozema, T, Ceha, H M, Grootenboers, D A R H, Neelis, K J, Stiggelbout, A M, and Pieterse, A H

Subjects
*RECTAL cancer, *RADIOTHERAPY, *RADIOTHERAPY safety, *ONCOLOGISTS, *SEXUAL dysfunction, *RECTAL cancer patients, RISK factors
Abstract

Background:For shared decision making to be successful, patients should receive sufficient information on possible benefits and harms of treatment options. The aim of this study was to evaluate what information radiation oncologists provide during the decision consultation about preoperative radiotherapy with rectal cancer patients.Methods:Decision consultations of 17 radiation oncologists with 81 consecutive primary rectal cancer patients, eligible for short-course radiotherapy followed by a low-anterior resection, were audio taped. Tapes were transcribed and analysed using the ACEPP (Assessing Communication about Evidence and Patient Preferences) coding scheme.Results:A median of seven benefits/harms were addressed per consultation (range, 2-13). This number ranged within and between oncologists and was not clearly associated with the patient's characteristics. A total of 30 different treatment outcomes were addressed. The effect of radiotherapy on local control was addressed in all consultations, the effect on survival in 16%. The most important adverse effects are bowel and sexual dysfunction. These were addressed in 82% and 85% of consultations, respectively; the latter significantly less often in female than in male patients. Four out of five patients did not initiate discussion on any benefits/harms.Conclusions:Our results showed considerable inconsistency between and within oncologists in information provision, which could not be explained by patient characteristics. This variation indicates a lack of clarity on which benefits/harms of radiotherapy should be discussed with newly-diagnosed patients. This suboptimal patient information hampers the process of shared decision making, in which the decision is based on each individual patients' weighing of benefits and harms. [ABSTRACT FROM AUTHOR]

Published
2015
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