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Activity recognition from wearable photo-cameras is crucial for lifestyle characterization and health monitoring. However, to enable its wide-spreading use in real-world applications, a high level of generalization needs to be ensured on unseen users. Currently, state-of-the-art methods have been tested only on relatively small datasets consisting of data collected by a few users that are partially seen during training. In this paper, we built a new egocentric dataset acquired by 15 people through a wearable photo-camera and used it to test the generalization capabilities of several state-of-the-art methods for egocentric activity recognition on unseen users and daily image sequences. In addition, we propose several variants to state-of-the-art deep learning architectures, and we show that it is possible to achieve 79.87% accuracy on users unseen during training. Furthermore, to show that the proposed dataset and approach can be useful in real-world applications, where data can be acquired by different wearable cameras and labeled data are scarcely available, we employed a domain adaptation strategy on two egocentric activity recognition benchmark datasets. These experiments show that the model learned with our dataset, can easily be transferred to other domains with a very small amount of labeled data. Taken together, those results show that activity recognition from wearable photo-cameras is mature enough to be tested in real-world applications.

In this paper, we give an overview on the emerging trend of the digitized self, focusing on visual lifelogging through wearable cameras. This is about continuously recording our life from a first-person view by wearing a camera that passively captures images. On one hand, visual lifelogging has opened the door to a large number of applications, including health. On the other, it has also boosted new challenges in the field of data analysis as well as new ethical concerns. While currently increasing efforts are being devoted to exploit lifelogging data for the improvement of personal well-being, we believe there are still many interesting applications to explore, ranging from tourism to the digitization of human behavior.

Aggregates of misfolded proteins are a hallmark of many age-related diseases. Recently, they have been linked to aging of Escherichia coli (E. coli) where protein aggregates accumulate at the old pole region of the aging bacterium. Because of the potential of E. coli as a model organism, elucidating aging and protein aggregation in this bacterium may pave the way to significant advances in our global understanding of aging. A first obstacle along this path is to decipher the mechanisms by which protein aggregates are targeted to specific intercellular locations. Here, using an integrated approach based on individual-based modeling, time-lapse fluorescence microscopy and automated image analysis, we show that the movement of aging-related protein aggregates in E. coli is purely diffusive (Brownian). Using single-particle tracking of protein aggregates in live E. coli cells, we estimated the average size and diffusion constant of the aggregates. Our results provide evidence that the aggregates passively diffuse within the cell, with diffusion constants that depend on their size in agreement with the Stokes-Einstein law. However, the aggregate displacements along the cell long axis are confined to a region that roughly corresponds to the nucleoid-free space in the cell pole, thus confirming the importance of increased macromolecular crowding in the nucleoids. We thus used 3D individual-based modeling to show that these three ingredients (diffusion, aggregation and diffusion hindrance in the nucleoids) are sufficient and necessary to reproduce the available experimental data on aggregate localization in the cells. Taken together, our results strongly support the hypothesis that the localization of aging-related protein aggregates in the poles of E. coli results from the coupling of passive diffusion-aggregation with spatially non-homogeneous macromolecular crowding. They further support the importance of "soft" intracellular structuring (based on macromolecular crowding) in diffusion-based protein localization in E. coli.