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As an estrogen-dependent disease, endometriosis was thought to become less active or regress with the onset of the menopause. However, based on some new data, we are discovering that this pathology can emerge or reappear at this period of life. Clinicians must consider it as a possible cause for cases of pelvic pain, and heavy bleeding. Authors have described a possibility of transformation of the intraperitoneal proliferation into a malignant type with ovarian, bowel and even lung metastasis. The risk of transformation into an ovarian cancer is around 2 or 3%. The role of menopausal hormonal therapy will be discussed as in recurrence in the case of residue existence, especially after incomplete surgery. Is it possible to prescribe hormonal therapy to a menopausal women suffering climacteric symptoms as it could trigger a recurrence of endometriosis and even an increased risk of malignant degeneration? This remains unclear. It is an unresolved therapeutic dilemma; the choice between surgery or medical treatment?

Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWH) are broadly used for the thromboprophylaxis during pregnancy. Long-term heparin therapy has raised concern about the risk of bone loss and osteoporotic fractures while pregnancy by itself favors osteoporosis. Experimental studies show a comparable effect of UFH and LMWH on bone formation while UFH has a more marked effect on bone resorption. Available clinical studies do not provide evidence of a difference between UFH and LMWH or among different LMWH on the bone risk. However, clinical studies show that bone loss observed with LMWH is not different from the physiological loss related to pregnancy, and osteoporotic fractures are associated with comorbidities or osteoporosis risk factors. LMWH represent the preferred alternative for thromboprophylaxis during pregnancy., (© 2013 Société Française de Pharmacologie et de Thérapeutique.)