1. The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe
- Author
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Dirk De Bacquer, Mickaël Maurice, Maria do Carmo Martins, Gérard Siest, Susanna Sans, Sophia Visvikis, Marianne Mansour Chemaly, Alun Evans, Christian Ehnholm, Nadia Haddy, Guy De Backer, Génétique épidémiologique et moléculaire des pathologies cardiovasculaires, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Public Health, and State University of Ghent
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Male ,Apolipoprotein E ,Aging ,030204 cardiovascular system & hematology ,Body Mass Index ,Doenças Cardio e Cérebro-vasculares ,Coronary artery disease ,chemistry.chemical_compound ,0302 clinical medicine ,MESH: Cholesterol ,Polymorphism (computer science) ,ApoEurope ,Genotype ,MESH: Aging ,Genetics (clinical) ,Genetics ,MESH: Aged ,Sex Characteristics ,0303 health sciences ,MESH: Middle Aged ,ApoE Concentration ,Smoking ,Middle Aged ,MESH: Apolipoproteins E ,3. Good health ,Europe ,Cholesterol ,Female ,lipids (amino acids, peptides, and proteins) ,MESH: Sex Characteristics ,Adult ,MESH: Triglycerides ,medicine.medical_specialty ,MESH: Smoking ,Biology ,Inter-individual Lipid Levels Variation ,MESH: Body Mass Index ,03 medical and health sciences ,Apolipoproteins E ,Contraceptive Agents ,Internal medicine ,Plasma lipids ,MESH: Polymorphism, Genetic ,medicine ,Humans ,Allele frequency ,Triglycerides ,Aged ,030304 developmental biology ,Polymorphism, Genetic ,MESH: Humans ,MESH: Contraceptive Agents ,Lipid metabolism ,MESH: Adult ,medicine.disease ,MESH: Male ,Endocrinology ,chemistry ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Europe ,ApoE Polymorphism ,MESH: Female ,Cardiovascular Risk - Abstract
The ApoEurope group, collaborating centres, and their associated investigators: Portugal: Unidade de Química Clínica, Instituto Nacional de Saúde, Lisboa: Maria do Carmo Martins, Maria Odete Rodrigues, Maria Isabel Albergaria, Maria Liseta Alpendre Interindividual variation in the concentration of plasma lipids which are associated with coronary artery disease (CAD) risk is determined by a combination of genetic and environmental factors. This study investigates the effects of apoE genotype and plasma concentration on cholesterol and triglycerides (TG) levels in subjects from five countries: Finland, France, Northern Ireland, Portugal, and Spain. Age and sex significantly influenced serum cholesterol, TG and apoE concentrations. The age effect differs in males and females. The allele frequencies of the apoE gene, one of the most widely studied CAD susceptibility genes, were determined: the epsilon2 allele frequency and the apoE concentration showed a north-south increasing gradient while the epsilon4 allele frequency showed the reverse. ApoE plays an important role in lipid metabolism. Total cholesterol and TG concentrations were significantly dependent on apoE genotype in both sexes. These differences in lipids between genotypes were more pronounced when plasma apoE concentrations were taken into account.
- Published
- 2002
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