Search

Your search keyword '"Marianna Stancampiano"' showing total 2 results
Start Over Author "Marianna Stancampiano"
2 results on '"Marianna Stancampiano"'

1. Predictors of surgical complications in boys with hypospadias: data from an international registry

Author

Tim Cheetham, Sukran Poyrazoglu, Justin H Davies, S Faisal Ahmed, Jillian Bryce, Anna Nordenström, Angela K Lucas-Herald, Paul-Martin Holterhus, Marcio Lopes Miranda, Stuart O’Toole, Eduardo Corrêa Costa, Kathryn Scougall, Federico Baronio, Rachel L Boal, Jose Roberto Castera, Sebastián Castro, Feyza Darendeliler, Mirjam Dirlewanger, Gabriella Gazdagh, Evgenia Globa, Gil Guerra-Junior, Tulay Guran, Gloria Herrmann, Ahsen Karagözlü Akgül, Renata Markosyan, Kenneth McElreavey, Gianni Russo, Valerie Schwitzgebel, Marianna Stancampiano, and Michael Steigert

Subjects
Pediatrics, RJ1-570, Surgery, RD1-811
Abstract

Background Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence.Methods Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher’s exact tests and spearman’s correlation tests were performed on the data to assess associations between clinical factors and complication rates.Results Of the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications.Conclusions Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation.

Published
2023
Full Text
View/download PDF

2. Anti-müllerian hormone and insulin-like 3 levels in healthy normal-weight ovulatory and anovulatory eumenorrheic late adolescent females: potential early biomarkers of ovarian dysfunction?

Author

Carla Pelusi, Alessandra Gambineri, Marianna Stancampiano, M. Pariali, Renato Pasquali, Flaminia Fanelli, Pelusi, C, Stancampiano, M, Fanelli, F, Pariali, M, Gambineri, A, and Pasquali, R.

Subjects
Anti-Mullerian Hormone, medicine.medical_specialty, endocrine system, Adolescent, medicine.drug_class, Radioimmunoassay, Dehydroepiandrosterone, Androgen, Anovulation, Young Adult, Follicle-stimulating hormone, Sex hormone-binding globulin, Tandem Mass Spectrometry, Sex Hormone-Binding Globulin, Internal medicine, medicine, AMH, Humans, Insulin, Testosterone, INSL3, Progesterone, Estradiol, biology, business.industry, 17-alpha-Hydroxyprogesterone, Androstenedione, Proteins, Obstetrics and Gynecology, Anti-Müllerian hormone, Luteinizing Hormone, medicine.disease, Cross-Sectional Studies, Endocrinology, Reproductive Medicine, Case-Control Studies, biology.protein, Female, Follicle Stimulating Hormone, Luteinizing hormone, business, Adolescent female, Chromatography, Liquid
Abstract

Objective The aim of this study was to evaluate differences in anti-mullerian hormone (AMH) and insulin-like 3 (INSL3) levels and their association with gonadotropin and ovarian steroid hormones, as expression of ovarian function, between healthy normal-weight ovulatory and anovulatory eumenorrheic late adolescent females. Study design This study analyzed AMH and INSL3 levels in forty healthy eumenorrheic late adolescent females (aged 16–19 ys), selected from a cross-sectional epidemiological study performed on the prevalence of hyperandrogenic states. The subjects were divided into ovulatory ( n : 28) and anovulatory ( n : 12) groups in accordance to a previous cluster analysis based on progesterone (P) distribution measured once in the latter part of the cycle. Both groups were compared for anthropometric, biochemical and hormonal parameters. Results INSL3 and AMH were detectable in all samples. Testosterone ( P = 0.01), the free-androgen index (FAI) ( P = 0.051), gonadotropins (LH: P = 0.02; FSH: P = 0.004) and AMH ( P = 0.02) levels were significantly higher in the anovulatory group with respect to their ovulatory counterpart. A trend toward significantly higher INSL3 concentrations ( P = 0.08) was also shown in the anovulatory group. A positive correlation between INSL3 levels and androgens such as androstenedione ( r = 0.38; P = 0.02), testosterone ( r = 0.44; P = 0.004) and FAI ( r = 0.42; P = 0.006) and a negative borderline significant correlation ( r = −0.30; P = 0.055) between AMH and P were shown in all subjects. Conclusion Healthy eumenorrheic late adolescent females with sporadic anovulation display higher AMH and INSL-3 blood concentrations in association with higher androgen levels compared with age- and BMI-matched subjects with ovulatory cycle, suggesting evidence of an earlier ovarian dysfunction.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results