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This article explores the relationship between leadership and spirituality in the context of individuals experiencing the condition of "fatherlessness." The phenomenon of fatherlessness, where individuals grow up without a father figure in their lives, can have significant impacts on one's leadership development and spiritual aspects. Through a literature analysis of Timothy, a figure in the New Testament, this paper analyzes how an individual can cultivate leadership qualities and spirituality in the context of fatherlessness. The integration of these spiritual values provides a strong foundation for the development of authentic and meaningful leadership. This study offers new insights into how individuals facing fatherlessness challenges can overcome them through the development of spirituality-based leadership. Abstrak Artikel ini membahas tentang hubungan antara kepemimpinan dan spiritualitas dalam konteks individu yang mengalami kondisi fatherless. Fenomena fatherless, di mana individu tumbuh tanpa figur ayah dalam kehidupannya, dapat memiliki dampak signifikan terhadap perkembangan kepemimpinan dan aspek spiritualitas seseorang. Melalui kajian literatur mengenai Timotius, tokoh dalam Perjanjian Baru, makalah ini menganalisis bagaimana seorang individu dapat mengembangkan kualitas kepemimpinan dan spiritualitasnya dalam kondisi fatherless. Integrasi nilai-nilai spiritual ini memberikan landasan yang kuat bagi pengembangan kepemimpinan yang autentik dan bermakna. Studi ini memberikan wawasan baru tentang bagaimana individu dalam kondisi fatherless dapat mengatasi tantangan tersebut melalui pengembangan kepemimpinan yang berbasis spiritualitas.

Incest is an iceberg phenomenon that is muted as it involves cultural, legal, economic, moral, psychological and human rights, where one and the other are interrelated, making it difficult to describe it. The purpose of this research is to observe the problem of incest from theological and cultural studies broadly concerning aspects of human life, both economic, social, educational, and biblical truth. The method used descriptive qualitative with theme analysis which will produce perspectives on incest broadly from cultural and theological studies based on Imago Dei's self-image, holiness and family according to God's design, the Creator of the household as a divine institution based on the Bible as the truth that absolute. The Old Testament records the emergence of cases of incest in the lives of the figures of faith which have the potential to cause ambiguity in adolescents, if Christian Education does not design the theme of incest in the curriculum as the context of teaching texts about holiness.

Potret pendidikan di Indonesia pada era revolusi industry 4.0 menuntut reformasi demi mengantar generasi milenial yang merupakan bonus demografi memasuki Indonesia Emas pada 2045 sehingga mereka menjadi anak bangsa yang siap bersaing di era globalisasi sekaligus sebagai manusia merdeka yang siap berkolaborasi untuk kebaikan bersama. Peserta didik sebagai generasi milenial tumbuh di lingkungan dengan tingkat kecanggihan sistem teknologi informasi yang massive sehingga menjadi tantangan bagi pendidik yang sebagian besar masih migrant-digital, sehingga pendidik perlu mengembangkan kompetensi dan profesionalitasnya dengan meningkatkan kemampuan dalam bidang teknologi komputerisasi demi efektivitas pembelajaran bagi peserta didik yang merupakan native-digital. Kajian model teologi praktis terhadap Pendidikan Agama Kristen penting mendasari pertimbangan dalam pemilihan strategi pembelajaran yang efektif dan relevan bagi peserta didik yang merupakan objek sekaligus subjek pendidikan baik di lingkungan lembaga pendidikan formal (sekolah), informal (keluarga) maupun nonformal (lembaga agama) sebagai pembekalan spiritualitas dan iman.

Abstract. The plurality of Indonesian society became a potential conflict that endangers the life of the nation and state if it was not managed properly. For this reason tolerance became an important attitude in living together. This article aimed to review efforts in buliding tolerance in the life of a pluralistic society. Through literature review it was descripted that tolerance could be built through a philosophy rooted in the local culture of Indonesian society. The "dining table" metaphor was an effective strategy in realizing tolerance in a pluralistic society. Abstrak. Kemajemukan masyarakat Indonesia menjadi suatu potensi konflik yang membahayakan keberlangsungan kehidupan berbangsa dan bernegara apabila tidak dikelola dengan baik. Untuk itu maka toleransi menjadi suatu sikap yang penting dalam kehidupan bersama. Artikel ini bertujuan untuk mengulas upaya membangun toleransi dalam kehidupan masyarakat yang majemuk. Melalui kajian pustaka tergambarkan bahwa toleransi dapat dibangun melalui falsafah yang berakar dari budaya masyarakat Indonesia. Metafora “meja makan” menjadi strategi yang efektif dalam mewujudkan tolerasi di tengah masyarakat yang majemuk.

INTRODUCTION: Endometrial carcinoma (EC) is the seventh most common cancer in females in Malaysia, of which the majority is composed of lower grade type I EC. Although less prevalent, type II EC which is of higher grade has poorer outcome and prognosis. Human epidermal growth factor receptor 2 (HER2) is one of the possible prognostic molecular markers which can be a target for immunotherapy. This study aimed to assess the expression of HER2 in common type of EC in the local population and to determine its correlation with the clinicopathological features. METHODS: a total of 53 cases of endometrioid type of EC were selected within a six-year period comprising of 22 cases of grade 1, 25 cases of grade 2 and six cases of grade 3 carcinoma. The selected whole tumour tissue sections were immune-stained with HER2 antibody. The scoring was semi-quantitatively an¬alyzed based on 2013 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAPs) guidelines for the scoring of HER2 in breast cancer. RESULTS: all cases regardless of grades of endometrioid carcinoma showed negative expression of HER2 (score 0). CONCLUSION: there was no significant HER2 expression in endometrioid carcinoma. However, a follow-up study with a larger number of samples from different type of endometrial carcinoma is needed. Testing of several tumour tissue blocks to assess possible tumour heterogeneity, as well as correlation with HER2 gene amplification status by in-situ-hybridisation, are also recommended.

Currently threatening the world of medicine is a growing number of antibiotic-resistant diseases. More specifically, bacteria and nematodes have gained resistance to many of the world's leading antibiotics and nematicides, respectively, making infections more difficult to treat. Subsequently, these parasitic organisms are able to continue damaging crops and other living organisms like humans without strong interference. To help people and the environment, the development of new and novel antibiotics is vital. Previous research suggests that phytochemicals are a potential solution that will not only help inhibit bacterial growth but also reduce nematode survival. We hypothesized that Myrica cerifera , a plant often used by the Lumbee tribe to treat illness, possesses antibacterial and nematicidal properties. To answer our hypothesis, we began by collecting plant specimens to extract material for biological assays and to subsequently isolate and elucidate the structures of active components. The extract was evaluated for antibacterial properties with an agar diffusion assay and then nematicidal properties using Caenorhabditis elegans . M. cerifera extract was added onto an agar lawn at various doses, and the nematodes' lifespans were scored. The findings of this study show that extracts of this plant, more commonly referred to as 'wax myrtle', do significantly decrease the lifespan of C. elegans and increase the zone of inhibition for Staphylococcus epidermidis and Staphylococcus aureus . In addition, two compounds were isolated and characterized through chemical extraction, chromatographic separation, and spectroscopic analysis. These compounds could potentially be used to treat bacterial and nematode infections.