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Background: Depression is a mental disorder that affects a large part of the world's population. DHEA is a hormone that has long been attributed to the ability to improve depressive symptoms. However, few studies were conducted with depression individuals not resulting from other medical conditions. Objective: To investigate whether DHEA is more effective than placebo in the treatment of depressive symptoms in subjects with depression not resulting from other psychiatric or medical comorbidities. Methods: An electronic search was carried out using the keywords Dehydroepiandrosterone (Mesh) AND Depression (Mesh) in the following databases: Medical Literature databases Analysis and Retrieval System Online (Medline), Excerpta Medical Database (EMBASE), Latin American and Caribbean Health Sciences (LILACS) and the Cochrane Library through their website for relevant publications until June 2018. Only randomized clinical trials were included. The critical appraisal of the articles was performed using the Risk of Bias Tool from Cochrane Collaboration. Results: The meta-analysis applied in this review pointed to a significant effect in favor of treatment with DHEA compared to placebo. Conclusion: DHEA may be one more effective alternative between the drugs used in the treatment of depression.

Current paper analyzes the performance of elderly people diagnosed with Mild Cognitive Impairment and with early phase Alzheimer´s Disease and healthy elderly people, by a set of neuropsychological tests. Statistical Analysis tests were significant when probability was < 0.05. Results showed that the neuropsychological tests discriminated cognitive deficits in the studied populations. There was a significant statistical association between all tests (when groups were compared) and clinical diagnosis. Patients with AD had the great slide in all tests when compared with patients with mild cognitive impairment and healthy elders. Neuropsychological standards are established and they will be of great help towards assessments and diagnoses. They will be an asset for more appropriate interdisciplinary measures of intervention in these populations.