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This cross-sectional study evaluated epidemiological and nutritional aspects as well as the microbial groups isolated from head and neck cancer patients, in the presence of oral mucositis. Three samplings were performed at baseline (jugal mucosa), on the 20 th radiotherapy session and on the last day of treatment, over oral mucositis lesions, if present. The sample was composed of 22 patients, mostly men (81.8%) and with a median age of 58.1(±12.7) years, 95% of them had concomitant smoking and drinking habits and 40.9% were edentulous. Body mass index values decreased during treatment and were statistically significant over time. During the study, there was a decline in Gram-positive cocci and an increase in Gram-negative rods. The recovery of yeast species increased along the study period. Isolation of multidrug-resistant microorganisms (44.3%) and those related to nosocomial infections (50.0%) was observed. Our findings suggested that there was a reduction in the indigenous oral microbiota and an increase in opportunistic species. The understanding of the microbial content of oral mucositis lesions as well as the clinical and nutritional aspects of head and neck cancer patients may contribute to a better oriented treatment.

In 2014, EFSA received a mandate from the European Commission (EC) to assess the risk and consequences of introduction of new vector-borne diseases (VBDs), and to determine if further measures were needed. To support the work, a comprehensive and systematic extraction of data from the literature was conducted, covering 36 VBDs in 18 host mammalian species. Regular updates of this corpus of scientific evidence are needed to support risk assessments. The foundation set by the previous rounds of literature review for VBDs can be reused to provide efficient and reliable collection of scientific evidence to support EFSA needs in various areas of knowledge. EFSA has been requested to provide support to the EC via scientific opinions that would form the basis for the production of amending and implementing acts supporting Regulation 2016/429 (of the European Parliament and of the Council of 9 March 2016 on transmissible animal diseases and amending and repealing certain acts in the area of animal health – the “Animal Health Law”), which lays down rules for the prevention and control of animal diseases which are transmissible to animals or to humans. To support EFSA in keeping the available VBD knowledge as an up-to-date source of information for risk assessors, and in providing scientific opinions in matters related to Regulation 2016/429, the methodology for literature review has been further consolidated in seven specific areas of knowledge: experimental infections, pathogen survival, diagnostic tests performance, vaccines, preventive and curative treatments, vector treatments and geographical distribution. This document details the review protocol to update the available knowledge about the 36 VBDs within those seven areas since the last systematic literature reviews were carried out in 2017; as well as extend them to the terrestrial animals category A diseases in the “Animal Health Law”.

Background: The outbreak of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered the rapid and successful development of vaccines to help mitigate the effect of COVID-19 and circulation of the virus. Vaccine efficacy is often defined as capacity of vaccines to prevent (severe) disease. However, the efficacy to prevent transmission or infectiousness is equally important at a population level. This is not routinely assessed in clinical trials. Preclinical vaccine trials provide a wealth of information about the presence and persistence of viruses in different anatomical sites. Methods: We systematically reviewed all available preclinical SARS-CoV-2 candidate vaccine studies where non-human primates were challenged after vaccination (PROSPERO registration: CRD42021231199). We extracted the underlying data, and recalculated the reduction in viral shedding. We summarized the efficacy of vaccines to reduce viral RNA shedding after challenge by standardizing and stratifying the results by different anatomical sites and diagnostic methods. We considered shedding of viral RNA as a proxy measure for infectiousness. Results: We found a marked heterogeneity between the studies in the experimental design and the assessment of the outcomes. The best performing vaccine candidate per study caused only low (6 out of 12 studies), or moderate (5 out of 12) reduction of viral genomic RNA, and low (5 out of 11 studies) or moderate (3 out of 11 studies) reduction of subgenomic RNA in the upper respiratory tract, as assessed with nasal samples. Conclusions: Since most of the tested vaccines only triggered a low or moderate reduction of viral RNA in the upper respiratory tract, we need to consider that most SARS-CoV-2 vaccines that protect against disease might not fully protect against infectiousness and vaccinated individuals might still contribute to SARS-CoV-2 transmission. Careful assessment of secondary attack rates from vaccinated individuals is warranted. Standardization in design and reporting of preclinical trials is necessary.

Introdução: Em 2008, para fortalecer a assistência no Sistema Único de Saúde (SUS), foi criado o Núcleo de Apoio a Saúde da Família (NASF). O NASF é formado por equipes de diversas áreas do conhecimento. O médico veterinário é um dos profissionais que pode compor as equipes do NASF, devido à sua atuação na área da saúde coletiva, zelando pela saúde humana. Objetivo: Descrever a importância da atuação do médico veterinário na Saúde Pública e a sua inserção no NASF. Metodologia: Realizou-se uma revisão integrativa da literatura avaliando a inserção do médico veterinário no NASF. Resultado: No passado, o médico veterinário era visto exclusivamente como um profissional voltado para o atendimento aos animais. No entanto, ao longo do tempo suas competências foram ampliadas ao contexto da Saúde Pública em programas de saúde coletiva. A partir dessas competências profissionais, o médico veterinário foi inserido com o propósito de trabalhar na Atenção Básica, particularmente no NASF. Nessa perspectiva, o profissional veterinário seria capaz de integrar as competências e habilidades relacionadas à saúde humana e animal. Conclusão: A inclusão do médico veterinário nas equipes do NASF amplia a capacidade de ações práticas com foco na prevenção de zoonoses. Observa-se uma carência na formação do médico veterinário voltado para a saúde pública e uma dificuldade de integração do médico veterinário no NASF.

Myiasis is an infection caused by the deposition of fly larvae in tissues, and its involvement in the human oral cavity is uncommon. Herein, we have performed a data analysis of published cases of oral myiasis. A search was performed in PubMed, Ovid, Web of Science, Scopus, and LILACS. Geographic distribution, demographic data, associated factors, clinical features, fly types, treatment, and presence of sequelae were analyzed. A total of 122 articles reported the cases of 157 infected individuals. The most affected countries were India (41%) and Brazil (29.5%). Male predominance (67.5%) and a mean of 41.9 years of age were observed. The gingiva (29%) was the most affected site, followed by palate (25%) and lip (21%). There were different forms and combinations of treatments: manual removal of larvae and surgical debridement, application of asphyxiating substances, antibiotic therapy, and use of ivermectin. The condition predominantly affects individuals with neurological and/or locomotor disabilities, of low socioeconomic status, with poor oral hygiene and chemical dependence and individuals with previous injuries or with the absence of lip sealing. The establishment of a standard treatment protocol, enabling comparison in future studies and providing uniformity in treatment strategies offered by health services is strongly recommended.

FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais O comércio de animais e produtos de origem animal é impulsionado pela demanda e aumento do poder de compra global, como resultado da expansão da população mundial, da crescente urbanização e do crescimento da classe média nas economias em desenvolvimento. Para atender esta crescente demanda por carne e produtos à base de carne, o setor mundial da produção de suínos tem experimentado um crescimento rápido ao longo das últimas décadas. Em suínos, doenças infecciosas tais como a Peste Suína Africana (PSA), têm sido controladas ou estão sob controle em muitas partes do mundo, por meio de programas de erradicação. No entanto, doenças podem aparecer esporadicamente em países livres como resultado da negociação de animais ou produtos animais, além de trânsito de pessoas. Como o comércio internacional é significante no que diz respeito à exportação de produtos de origem animal, o presente trabalho objetiva caracterizar o comércio internacional de carne suína e verificar os impactos de ocorrência de Peste Suína Africana nesse contexto. As informações de comércio obtidas no TradeMap, foram avaliadas e cruzadas com dados de ocorrência de PSA oriundos da Organização Mundial de Saúde Animal (OIE). Durante o período de estudo, 228 países estavam envolvidos na exportação e/ou importação de produtos de carne suína (fresca, resfriada ou congelada). Cerca de 53.849.513 toneladas de produtos foram exportadas nos 5 anos observados. Na soma do período, houve 26 ocorrências de países que eram exportadores e positivos para a doença. Porém, ocorrências de países exportadores e negativos para doença foram mais significativas, com uma soma de 527 ocorrências. Animal and animal products trade is driven by demand and increased global purchasing power as a result of an expanding world population, growing urbanization and middle-class growth in developing economies. In order to meet this growing demand for meat and meat products, the world pork production sector has experienced rapid growth over the past few decades. Infectious diseases such as African Swine Fever (ASF) have been controlled or are under control in many parts of the world through eradication programs. However, diseases may appear sporadically in free countries as a result of trading animals or animal products, in addition to people transit. As international trade is significant with respect to commercialization of animal products, the present retrospective, descriptive and ecological study aims at characterizing the world's pork trade Network and the occurrence of African Swine Fever, by considering the years of 2012 to 2016. The trade information obtained from TradeMap was evaluated and cross-checked with ASF data from the World Organization for Animal Health (OIE). During the study period, 228 countries were involved in the export and/or import of pork products (fresh, chilled or frozen). About 53,849,513 tons of products were exported in the 5 years observed. In the sum of the period, there were 26 occurrences of countries that were exporters and positive for the disease. However, occurrences of exporting and disease-negative countries were more frequent, with a sum of 527 occurrences.

Background: The largest buffalo herd in Brazil is located on the Island of Marajó, in the State of Pará, northern Brazil. The pastures of the Island of Marajó consist of low quality graminaceous plants, which are generally poor in protein and mineral content. Unbalanced diets associated with low quality pastures are responsible for latent, sub-clinical diseases and metabolic disorders in bovines which affect bone health, especially in periods such as pregnancy and lactation. The purpose of this study was to point out and to describe the radiographic bone changes of buffalos with low body index bred in extensive system and intended for slaughter on the Island of Marajó, Brazil.Materials, Methods & Results: Radiographic examinations of anatomical pieces were obtained from 34 animals of buffalo species, with no distinction of gender, age, or breed. The animals were selected among those that were in the stockyard waiting for slaughtering for the obtainment of the anatomical pieces. For this selection, low physical condition was considered, which mainly included individuals with body condition indexes (ICC) of 1 and 2, on a scale of 1 to 5. From this selection, 98 anatomical pieces were obtained, which included: 28 sets of ribs, 20 femurs, 26 metacarpus, 7 mandibles, 3 radius and ulnas, 4 sets of vertebrae, 4 sets of metacarpus and phalanges, 1 tarsus and 1 set of tarsus and metatarsus. All the pieces were separated, identified, packed in plastic bag and forwarded to the radiographic study. At least one radiographic projection was obtained of each anatomical piece. These were identified, manually processed and stored for subsequent assessment. A single observer, in order to identify and to describe the bone radiographic changes, subjectively performed the radiographic assessment.Discussion: Bone changes were remarkable and in animals of this study, reinforcing the nutritional aspect as being of great importance for the perfect mineral homeostasis and for the osteoarticular system maintenance. Consistent radiographic findings with osteopenia are most often related to nutritional disorders that affect bone metabolism, mainly involving the homeostasis of calcium (Ca) and phosphorus (P). The nutritional hyperparathyroidism, more commonly reported in dogs, cats and exotic animals is a common example of these affections, in which the bone radiopacity reduction is the most evident radiographic aspect. Copper (Cu) deficiency has been correlated with osteochondrosis, epiphyseal fracture of the femoral head and degenerative arthropathy of the hip joint, and erosion of the articular cartilage in a deer (Cervu selaphus). Degenerative arthropathy through radiographs was also found in this study. From the bone radiographic analysis, it is concluded that the osteodystrophic diseases of buffalos raised in pasture system on the Island of Marajó, Pará, Brazil, present a variety of pathological conditions and the most commonly found were: osteoporosis characterized at the radiographic examination for the bone decreased radiopacity, change in bone trabeculae (medullary expansion) and cortical thinning, followed by pathological fractures with high incidence in the ribs. The low body condition, the underdevelopment and cachexia states of the animals in this study indicate the lack of an appropriate prophylactic conduct and a proper feed management. Therefore, the low reserves of P and Cu in the organism may have contributed to the osteoporotic process and, possibly, also to the protein-energy deficit, leading to secondary bone changes and causing a lack of productivity in the herd.

Background: The splenic torsion is a rare condition in dogs, especially when it is not associated with gastric dilatation and volvulus. Abdominal ultrasonography has been reported as an accurate diagnostic method in cases of splenic torsion suspicions. Splenomegaly, decreased echogenicity of the parenchyma of the spleen and hypoechoic appearance or “lace” are suggestive sonographic findings, although the definitive diagnosis is given through exploratory laparotomy. This study reports a case of splenic torsion followed by abdominal trauma and eventration in a dog, highlighting the importance of the ultrasound examination.Case: An adult dog without a defined breed pattern that weighed 8.6 kg was referred to the Veterinary Hospital of the Federal University of Lavras (Universidade Federal de Lavras - UFLA) with a history of trauma caused by having been run over by a car 24 h earlier. The animal exhibited right inguinal region swelling with hematoma and a loss of local muscular tension. An abdominal ultrasound indicated that the spleen was displaced to the right inguinal region and that a portion of the spleen was included in the animal’s abdominal eventration. The spleen possessed an irregular surface with increased dimensions and diffusely decreased echogenicity and multiple parallel echogenic lines (in the reticular aspect). Abrupt differences in the echogenic textures of the spleen were identified in certain images. Color Doppler assessments revealed no blood flow. Based on the aforementioned ultrasound findings, an exploratory laparotomy was indicated. The laparotomy confirmed the presence of right inguinal abdominal muscle rupture with dislocation, eventration, and splenic torsion.Discussion: Splenic torsion may be most frequently reported in cases involving large and giant male dogs because this condition is typically related to dilatation syndrome and gastric volvulus, which are more prevalent among large and giant male dogs than among other dogs. Although these etiological factors should be considered, in the case examined in this study, the patient most likely suffered from splenic torsion caused by abdominal trauma, which resulted in the rupture of the gastrosplenic and splenocolic ligaments and the splenic vessels and thereby created circumstances conducive to splenic eventration and torsion. The sonographic features of splenic torsion in dogs include marked splenomegaly, a hypoechoic or diffuse anechogenic pattern that indicates the presence of vascular congestion, and sinusoidal dilatation separated by small linear echoes that represent dilated vessels. In cases of splenic torsion, two-dimensional ultrasonographic images may reveal an enlarged spleen with a hypoechoic echotexture and a hyperechoic triangle between the veins and the splenic parenchyma continuous to the hyperechoic mesentery. The sonographic findings observed in the patient examined in this study were similar to the findings described in the published literature and consistent with the results reported by the other authors. Although extensive literature reports have described the sonographic aspects of splenic torsion in dogs, this disease remains uncommon. Moreover, no prior reports have described splenic torsion secondary to concurrent abdominal trauma, displacement, and eventration; thus, the case examined in this study is unprecedented, and the ultrasonographic aspects observed in this case should be considered.

The poultry farm of posture is an economic activity of great relevance to Brazil. Health aspects of flocks of laying chickens, such as the occurrence of infestations by parasites and poultry pests, influence significantly the productivity indicators. In this context, the control of synanthropic diptera is one of the challenges of the poultry farmers and professionals of this area. In Brazil, the control of flies in poultry environments is based mainly on the use of pesticides, while other alternatives are less frequent. Among the flies’ species most regularly found in poultry farms are the Musca domestica, Chrysomya spp., Fannia spp., and others. This review aims at compiling the literature on the occurrence, impact on poultry systems, biology, epidemiology and control of the species of synanthropic flies considered important for the Brazilian poultry industry. RESUMO: A avicultura de postura é uma atividade econômica de grande relevância para o Brasil. Aspectos sanitários dos plantéis de galinhas poedeiras, tais como infestações por parasitos e pragas avícolas, influenciam significativamente os indicadores de produtividade desse setor. Nesse contexto, o controle de dípteros sinantrópicos constitui um dos desafios de avicultores e profissionais da área. No Brasil, o controle de moscas em ambientes avícolas é baseado, sobretudo, no uso de pesticidas, ao passo que o uso de outras alternativas é menos recorrente. Entre as espécies de moscas mais frequentes em granjas avícolas de postura, destacam-se Musca domestica, Chrysomya spp., Fannia spp., entre outras. O objetivo desta revisão é realizar a compilação da literatura existente sobre a ocorrência, o impacto nos sistemas avícolas, a biologia, a epidemiologia e o controle das espécies de dípteros sinantrópicos consideradas importantes para a avicultura de postura brasileira.