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Temos caminhado para um futuro promissor no qual as tecnologias realmente alcancem todos e proporcionem um melhor desenvolvimento humano. Isso é o que poderemos ver nos artigos publicados e repensar qual é a nossa função nessa transformação.

About 30% to 40% of cancers can be prevented through healthy diet, adequate body weight and regular physical activity. The adherence to lifestyle recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) has been associated with lower risk of death in cancer survivors. The objective of this study was to evaluate adherence to the new recommendations of the WCRF/AICR by Brazilian women in adjuvant hormone therapy for breast cancer and its associated factors. This cross-sectional study was carried out from January to August 2017, in Santa Maria, RS. Regarding the recommendations of the WCRF/AICR the average adherence score was 4.4 points out of a total of 8 points. Higher adherence is associated with higher schooling. In individual recommendations, physical activity showed the lowest adherence whereas alcohol consumption showed the highest adherence. The data suggest that Brazilian breast cancer survivors, especially those with lower levels of education, could benefit from dietary counseling and physical activity.

The aim of the present study was to evaluate oral health–related quality of life (OHRQoL) among breast cancer survivors and identify possible factors associated with the outcome. A cross-sectional study was conducted with 151 women in follow-up at a hospital after treatment for breast cancer. Data were collected on socio-demographic characteristics, general health, and breast cancer. Clinical examinations were performed to determine caries experience using the decayed, missing, and filled teeth (DMFT) index. The Oral Health Impact Profile (OHIP-14) questionnaire was administered for the assessment of OHRQoL. Logistic regression analysis was performed to identify associated factors after adjustments for confounding variables. The mean OHIP-14 score was 12.8 (SD 10.92). The prevalence of negative impact was 58.9%. A negative impact was associated with depression, the diagnosis of breast cancer, chemotherapy, number of restored teeth, and xerostomia (p

Wood is rich in organic compounds; thus, it is susceptible to attacks by several deteriorating agents because they acknowledge such attacks as a necessary energy supply. Fungi stand out among these agents since they can attack the wood in trees (before felling) and in several post-felling stages. Fungi are biological agents that use organic compounds as food sources, and that is the reason why they degrade most chemical components found in wood. Wood attacked by fungi suffers significant value loss, since these degrading agents affect their mechanical and aesthetic properties. Fungi — which are classified as staining, molding and rotting — are one of the main responsible for the biggest losses in the timber industry. Wood can be virtually used in a whole range of environments, a fact that makes it susceptible to attacks by different fungal species, since the ideal conditions for fungal development change from species to species. In other words, the fact that one or more fungal species are capable of deteriorating wood is directly related to conditions wood is subjected to. Thus, it is essential knowing how to evaluate fungal attacks, symptoms to be taken into consideration at the time to identify the type of attacking organism and the attack stage, as well as the control and prevention measures to be applied to these organisms. RESUMO: Rica em compostos orgânicos, a madeira é suscetível ao ataque de diversos agentes deterioradores por ser reconhecida como suprimento necessário de energia. Entre esses agentes, destacam-se os fungos, cujo início de ataque pode se dar ainda na árvore, antes do abate e nas diversas fases posteriores. Os fungos são agentes biológicos que necessitam de compostos orgânicos como fontes de alimento e, por essa razão, degradam grande parte dos componentes químicos da madeira. As madeiras, quando atacadas por fungos, sofrem grandes perdas de valor, afetando suas propriedades mecânicas e estéticas. Os fungos são considerados um dos principais responsáveis pelos maiores prejuízos na indústria madeireira e são classificados como manchadores, emboloradores e apodrecedores. Praticamente, a madeira pode estar em uso em uma variedade de ambientes; sabendo-se que as condições ideais de desenvolvimento de um fungo são diferentes para cada espécie, a madeira ficará suscetível ao ataque por diferentes espécies de fungos. Ou seja, o fato de uma ou mais espécies de fungos serem encontradas deteriorando a madeira está diretamente relacionado às condições em que ela se encontra. Dessa forma, torna-se importante saber como avaliar os ataques feitos por fungos, os sintomas a serem considerados para identificar o tipo de organismo e o estágio do ataque, bem como as medidas de controle e prevenção desses organismos.

Azadirachtin (Aza) is a promisor biopesticide used in organic production and aquaculture. Although this compound is apparently safe, there is evidence that it may have deleterious effects on fish. Behavioral and hematological tests are grouped into a set of parameters that may predict potential toxicity of chemical compounds. Here, we investigate the effects of Aza, in the commercial formulation Neenmax™ , on carp (Cyprinus carpio) by defining LC50 (96 h), and testing behavioral and hematological parameters. In our study, LC50 was estimated at 80 μL/L. We exposed carp to Aza at 20, 40, and 60 μL/L, values based on 25, 50, and 75% of LC50 , respectively. At 60 μL/L, Aza promoted significant changes in several parameters, increasing the distance traveled and absolute turn angle. In addition, the same concentration decreased the time spent immobile and the number of immobile episodes. Hematological parameters, such as hematocrit, hemoglobin, hematimetrics index, and red cell distribution, were decreased at 60 μL/L Aza exposure. In conclusion, our study demonstrates that 60 μL/L Aza altered locomotor activity, motor pattern, and hematological parameters, suggesting potential toxicity to carp after acute exposure. In addition, this is the first report that evaluates the actions of a chemical contaminant using automated behavioral tracking of carp, which may be a useful tool for assessing the potential toxicity of biopesticides in conjunction with hematological tests. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1381-1388, 2016.

This study investigated the δ-aminolevulinate dehydratase (δ-ALA-D) activity in whole blood as well as the parameters of oxidative stress, such as reactive species (RS) levels in serum, thiobarbituric acid reactive substances (TBARS) levels, the superoxide dismutase (SOD) and catalase (CAT) activities, as well as total thiols (T-SH) and non-protein thiols (NPSH) levels in platelets. Moreover, the content of vitamin C and E in plasma and serum, respectively, in lung cancer patients was also investigated. We collected blood samples from patients (n=28) previously treated for lung cancer with chemotherapy. Patients were classified as stage IIIb and IV according to the Union for International Cancer Control (UICC). Results showed a decrease of 37% in δ-ALA-D activity in patients with lung cancer when compared to the control group. RS and TBARS levels were 8% and 99% higher in the patient group, respectively. The activity of SOD and CAT as well as the vitamin C content were 41%, 35% and 127% lower in patients when compared with controls, respectively. However, T-SH and vitamin E levels were 27% and 44% higher in lung cancer patients, respectively. Results show that the overproduction of reactive species in patients with lung cancer may be interfering with the activity of δ-ALA-D. Likewise, the decrease in the activity of this enzyme may be contributing for the oxidative stress.

Ethnopharmacological relevance The Ashaninkas, indigenous people of Peru, use cat's claw (Uncaria tomentosa) to restore health. Uncaria tomentosa has antioxidant activity and works as an agent to repair DNA damage. It causes different effects on cell proliferation depending on the cell type involved; specifically, it can stimulate the proliferation of myeloid progenitors and cause apoptosis of neoplastic cells. Neutropenia is the most common collateral effect of chemotherapy. For patients undergoing cancer treatment, the administration of a drug that stimulates the proliferation of healthy hematopoietic tissue cells is very desirable. It is important to assess the acute effects of Uncaria tomentosa on granulocyte-macrophage colony-forming cells (CFU-GM) and in the recovery of neutrophils after chemotherapy-induced neutropenia, by establishing the correlation with filgrastim (rhG-CSF) treatment to evaluate its possible use in clinical oncology. Materials and methods The in vivo assay was performed in ifosfamide-treated mice receiving oral doses of 5 and 15 mg of Uncaria tomentosa and intraperitoneal doses of 3 and 9 μg of filgrastim, respectively, for four days. Colony-forming cell (CFC) assays were performed with human hematopoietic stem/precursor cells (hHSPCs) obtained from umbilical cord blood (UCB). Results Bioassays showed that treatment with Uncaria tomentosa significantly increased the neutrophil count, and a potency of 85.2% was calculated in relation to filgrastim at the corresponding doses tested. An in vitro CFC assay showed an increase in CFU-GM size and mixed colonies (CFU-GEMM) size at the final concentrations of 100 and 200 μg extract/mL. Conclusions At the tested doses, Uncaria tomentosa had a positive effect on myeloid progenitor number and is promising for use with chemotherapy to minimize the adverse effects of this treatment. These results support the belief of the Ashaninkas, who have classified Uncaria tomentosa as a ‘powerful plant’.

Background Acute lymphoblastic leukemia (ALL) is a type of cancer that affects lymphocytes and it is the most common form of cancer in children. Acetylcholinesterase (AChE) is well known as having non-cholinergic functions and has been detected in the blood and plasma of humans including in lymphocytes. Thus, we investigated whole blood and lymphocyte AChE activity in patients with ALL. Methods This study was performed on 72 children with ALL divided into 4 groups: newly diagnosed, remission induction, remission maintenance and out-of-treatment and one control group of 50 healthy subjects. We determined AChE activity in whole blood and lymphocytes of these patients. Results Results demonstrated that whole blood AChE activity was enhanced in the newly diagnosed group and reduced in the remission induction and remission maintenance groups in relation to the control group. For lymphocyte AChE activity we found an increase in the newly diagnosed group and a decrease in the remission induction group in relation to the control. Conclusions These results suggest that AChE activity was altered in ALL patients. This fact may be related with the essential role played by AChE in the development of hematological disease and its contribution to the regulation of immune function.

Objectives To evaluate the oxidative status and antioxidant defense in patients with acute lymphoblastic leukemia (ALL). Design and methods We measured concentrations of plasmatic thiobarbituric acid reactive substances (TBARS), serum protein carbonylation, whole blood catalase (CAT) and superoxide dismutase (SOD) activities, as well as the plasmatic and erythrocyte thiol levels and serum vitamin E concentration. This study was performed on 80 children with ALL divided into 4 groups: just diagnosed, remission induction, remission maintenance and out-of-treatment. Results TBARS levels and serum protein carbonylation were higher in ALL patients than in controls and reduced levels of antioxidants were found in these patients. Conclusion These findings may indicate a possible link between decreased antioxidants and increased levels of cells alterations due to oxidative damage, supporting the idea that there is a persistence of oxidative stress in acute lymphoblastic leukemia.

Ethopharmacological relevance Uncaria tomentosa (Willd.) DC. (Rubiaceae) (Ut), also known as cat's claw, is a woody liana widely spread throughout the Amazon rainforest of Central and South America, containing many chemical constituents such as oxindole alkaloids, which are responsible for various biological activities. Since ancient times, the indigenous people of Peru have used it as a bark infusion for the treatment of a wide range of health problems gastric ulcers, arthritis and rheumatism. Recently, Ut is distributed worldwide and used as an immunomodulatory and anti-inflammatory herbal remedy. Additionally, U. tomentosa also has antitumural activity. However, little is known about the action of U. tomentosa on the purinergic system mechanisms, which is involved in tumor progression. Aim of the study Considering the pharmacological properties of U. tomentosa, we sought to evaluate the hydroalcoholic extract U tomentosa is able to influence the purinergic system in breast cancer cells, MDA-MB-231. Through the activity and expression of ectonucleotidases (NTPDase – CD39; Ecto-5′-nucleotidase – CD73) and purinergic repceptores (P2X7 and A1). Materials and methods A hydroalcoholic extract was prepared in two concentrations, 250 and 500 μg/mL. (Ut250; Ut500). The effect of these concentrations on the activity and expression of ectonucleotidases, as well as on the density of purinergic receptors were investigated in MDA-MB-231 breast cancer cells. Cells were treated with the hydroalcoholic extract of Uncaria tomentosa and/or doxorubicin (Doxo 1 μM; Ut250+Doxo; Ut500+Doxo) for 24 h. Results Although the results were not significant for the hydrolysis of the ATP, they presented an increase in the ADP hydrolysis in the Ut500+Doxo group when compared to the control group. Additionally, the activity of 5′-nucleotidase was inhibited in all groups when compared with the untreated group of cells. Inhibition of the enzyme was more evident in groups with U. tomentosa per se. The expression of CD39 was increased in the Ut250 and Ut250+Doxo groups when compared to the control group. No changes were found in the CD73 expression. Furthermore, a reduction in the density of the P2X7 receptor in all treated groups was detected. On the other hand, the density of the A1 receptor increased in all groups compared to the control group, with the exception of the Ut500+Doxo group. Conclusion Therefore, we conclude that hydroalcoholic extract of U. tomentosa may be responsible for the reduction of adenosine levels in the extracellular medium, which accelerates tumor progression. Interestingly, the dysregulation of A1 and P2X7 receptors in the MDA-MB-231 cells exacerbate the proliferation of this cells and U. tomentosa treatment may be stimulate the antitumor activity of adenosine A1 receptor and control the P2X7 effects. Our study demonstrates the significant participation of purinergic pathway in the regulation of MDA-MB-231 progression; additionally, U. tomentosa treatment alone or combined with chemotherapy may favor the action of doxorubicin.

The activities of the enzymes NTPDase (E.C.3.6.1.5, apyrase, ATP diphosphohydrolase, ecto-CD39) and 5′-nucleotidase (E.C.3.1.3.5, CD73) were analyzed in platelets from patients with chronic renal failure (CRF), both undergoing hemodialysis treatment (HD) and not undergoing hemodialysis (ND), as well as from a control group. The results showed an increase in platelet NTPDase activity in CRF patients on HD treatment (52.88%) with ATP as substrate (P

Outsourcing has emerged as one of the new ways of guiding the work. For its advantages and be consistent with the paradigms of managerial reform, outsourcing also started to be used in the Public Administration. However, taking into account the particularities of the latter, some issues are relevant when outsourcing concluded with the State. Gains notoriety, for example, the step of monitoring these contracts, to the extent that, from this activity, we can avoid the negative effects of outsourcing like the fact that the state will pay for labor and wage liens that are obligation of the company providing the services. This study aims to understand the perception that this process is under the Federal University of Rio Grande do Norte, from the point of view of different stakeholders, also explaining the motivations that these agents have to perform the supervisory process. As a theoretical basis was used the Agency Theory, which reinforces the supervisory activities as a necessary means to minimize moral hazard and adverse selection, seeking to understand not only the different motivations tax contracts to properly perform their duties, but also analyze other phenomena arising from this contractual relationship. To achieve the proposed objectives, were taken a literature review and a presentation of how to organize the management and oversight of contracts in UFRN. The methodological procedures included questionnaires and interviews with those involved in the process. After analyzing the results obtained in the survey instruments , and also based on the laws, regulations and instructions governing the procurement process within the UFRN, it was concluded that the process of overseeing the outsourcing of labor contracts in UFRN is not fully institutionalized, some points should be strengthened in order to have the consolidation of this process, highlighting the need for training of UFRN servers that act as tax, the knowledge that the contractual penalties are applied effectively, the need that there is a supervisor of tax of contractors and also the realization of the rotation system of outsourced employees A terceirização surgiu como uma das modalidades novas de orientação do trabalho. Por suas vantagens e por estar em consonância com os paradigmas da Reforma Gerencial, a terceirização também passou a ser utilizada na Administração Pública. Todavia, levando-se em consideração as particularidades desta última, algumas questões se mostram relevantes quando da terceirização celebrada com o Estado. Ganha notoriedade, por exemplo, a etapa de fiscalização desses contratos, na medida em que, a partir dessa atividade, podem-se evitar os efeitos negativos da terceirização, como o fato de que o Estado venha a arcar com ônus trabalhistas e salariais que são de obrigação da empresa prestadora dos serviços. O presente trabalho tem por objetivo compreender qual a percepção que se tem desse processo no âmbito da Universidade Federal do Rio Grande do Norte, sob o ponto de vista dos diferentes agentes envolvidos, explicando, ainda, quais as motivações que esses agentes possuem para o desempenho do processo de fiscalização. Como embasamento teórico, foi utilizada a Teoria da Agência, a qual reforça a atividade de fiscalização como meio necessário para minimizar o risco moral e a seleção adversa, buscando entender não só as diferentes motivações que levam os fiscais dos contratos a desempenharem corretamente as suas atribuições, mas, também, analisar outros fenômenos decorrentes dessa relação contratual. Para alcançar os objetivos propostos, foi feita uma revisão da literatura e uma apresentação de como se organiza a gestão e fiscalização dos contratos na UFRN. Os procedimentos metodológicos incluíram questionários e entrevista com os agentes envolvidos no processo. Após a análise dos resultados obtidos nos instrumentos de pesquisa, e baseando-se também nas leis, instruções normativas e contratos que disciplinam o processo no âmbito da UFRN, concluiu-se que o processo de fiscalização dos contratos de terceirização de mão de obra na UFRN não está totalmente institucionalizado, devendo alguns pontos serem reforçados para que se tenha a consolidação desse processo, destacando-se a necessidade de treinamento dos servidores da UFRN que atuam como fiscais, o conhecimento de que as penalidades contratuais são efetivamente aplicadas, a necessidade de que exista um supervisor dos fiscais das empresas contratadas e, ainda, a efetivação do sistema de rodízio dos funcionários terceirizados

The aim of this study was to assess whether α-tocopherol administration prevented alterations in the ectonucleotidase activities and platelet aggregation induced by high-fat diet in rats. Thus, we examined four groups of male rats which received standard diet, high-fat diet (HFD), α-tocopherol (α-Toc), and high-fat diet plus α-tocopherol. HFD was administered ad libitum and α-Toc by gavage using a dose of 50 mg/kg. After 3 months of treatment, animals were submitted to euthanasia, and blood samples were collected for biochemical assays. Results demonstrate that NTPDase, ectonucleotide pyrophosphatase/phosphodiesterase, and 5′-nucleotidase activities were significantly decreased in platelets of HFD group, while that adenosine deaminase (ADA) activity was significantly increased in this group in comparison to the other groups (P

Breast cancer is the most frequent neoplasm affecting women worldwide. Some of the recommended treatments involve chemotherapy whose toxic effects include leukopenia and neutropenia. This study assessed the effectiveness ofUncaria tomentosa(Ut) in reducing the adverse effects of chemotherapy through a randomized clinical trial. Patients with Invasive Ductal Carcinoma—Stage II, who underwent a treatment regimen known as FAC (Fluorouracil, Doxorubicin, Cyclophosphamide), were divided into two groups: the UtCa received chemotherapy plus 300 mg dry Ut extract per day and the Ca group that only received chemotherapy and served as the control experiment. Blood samples were collected before each one of the six chemotherapy cycles and blood counts, immunological parameters, antioxidant enzymes, and oxidative stress were analyzed.Uncaria tomentosareduced the neutropenia caused by chemotherapy and was also able to restore cellular DNA damage. We concluded that Ut is an effective adjuvant treatment for breast cancer.

Demonstra-se lesão dermatológica, em caprichoso formato de coração, característica de ataque por caravela-portuguesa, em banhista do sexo feminino, 21 anos It is reported the case of a 21-year-old female bather with a skin lesion, heart-shaped ,characteristic of attack by jellyfish

It is reported the case of a 21-year-old female bather with a skin lesion, heart-shaped ,characteristic of attack by jellyfish.

Von Willebrand disease (VWD) is one of the most common inherited bleeding diseases caused by a qualitative or quantitative deficiency of the von Willebrand factor (FvW). FvW is a multimeric glycoprotein synthesized by megakaryocytes and endothelial cells and it is present in the subendothelial matrix, blood plasma, platelets, and endothelium. This glycoprotein plays an important role in thrombus formation by initiating platelet adhesion to sites of injury as well as platelet aggregation. The aim of this study was to evaluate the activities of enzymes that hydrolyze adenine nucleotides in platelets, ristocetin-induced platelet aggregation (RIPA), and polymorphisms of the alpha2 gene of alpha2beta1 integrin from VWD patients. Platelet nucleoside triphosphate diphosphohydrolase (NTPDase), 5'-nucleotidase, and ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP) activities were verified in 14 VWD patients. For RIPA determination, a final concentration of 1.25 mg/ml of ristocetin was used. Polymorphisms of the alpha2 gene were analyzed through PCR. Platelet NTPDase and E-NPP were decreased in VWD patients. 5'-Nucleotidase activity was not statistically significant between controls and VWD patients. RIPA was significantly reduced, with an allelic frequency of 78.57% for 807C in VWD patients. Our results indicated reduced platelet NTPDase and E-NPP activities which might be related to the low platelet adhesiveness. The prevalence of the 807C allele might account for the variability in bleeding in VWD.

The objective of this work was to evaluate the effect of different glucose levels on the ATP, ADP and AMP hydrolysis in the platelets of diabetic, hypertensive and diabetic/hypertensive participants.The activities of the enzymes NTPDase (ATP and ADP hydrolysis) and 5'-nucleotidase (AMP hydrolysis), and CD39 expression were analyzed in human blood platelets of diabetic (DM-2), hypertensive (HT) and diabetic/hypertensive (DM-2/HT) patients. To evaluate the interference of glucose and fructose in NTPDase and 5'-nucleotidase activities, experiments were performed with glucose, fructose and mannitol concentrations ranging from 5 to 30 mM in platelet-rich plasma (PRP). Pre-incubation times of 10, 120 min and 24h were used.NTPDase and 5'-nucleotidase activities increased with increasing glucose and fructose concentrations (P0.001) and the different times of pre-incubation did not interfere in ectonucleotidases activities (P0.5). NTPDase and 5'-nucleotidase activities demonstrated a positive correlation between serum glucose levels and ATP and ADP hydrolysis in DM-2 and DM-2/HT patients. CD39 expression demonstrated that DM-2, HT and DM-2/HT groups presented a significant increase when compared to the control group (P0.004).The hydrolysis of adenine nucleotides is enhanced in platelets of patients with diabetes and hypertension. We observed that an increasing glucose concentration had a direct effect on ATP, ADP and AMP hydrolysis. Furthermore, CD39 expression was enhanced in all patients groups, indicating that these enzyme activities are related with diabetes and hypertension.

Background Cervical cancer is a major cause of morbidity among women. We investigated the treatment effect on oxidative status from patients submitted to radiotherapy or conization surgery to high-grade SIL (squamous intraepithelial lesion) treatment, and oxidative profile from patients newly diagnosed for uterine cervix cancer, without treatment. Methods We determined the catalase activity in blood, reduced glutathione (GSH) in plasma, TBARS and protein carbonyl content from serum samples of the patients. Results The catalase activity, GSH levels, TBARS and protein carbonyl content had no statistical differences related to the controls, neither when the 2 treatments were compared, possibly because the antioxidant defense may be acting in the first period of the neoplasic transformation, and maybe indicating a possible arrest of the tumor cells caused by the efficiency of the treatments. In the non-treated patients, TBARS and protein carbonyl contents, GSH levels and catalase activity were shown to be increased comparing with the treated patients and compared with the controls indicating an tumor effect on oxidative profile, and the antioxidant activity been increased in the beginning of the tumor development. Conclusions We suggest that the treatments were efficient in arrest of the tumor.

Foi conduzido um ensaio de campo em Seropédica, Estado do Rio de Janeiro, para avaliar o efeito da solarização do solo na população infestante de tiririca (Cyperus rotundus) e na produtividade de hortaliças submetidas a manejo orgânico. A solarização correspondeu à cobertura do solo com polietileno transparente (50 mim) por um período de 210 dias. Houve um aumento da temperatura média da camada superficial do solo (0-10 cm) da ordem de 23%, em relação ao das parcelas não-solarizadas. Após a retirada do plástico, cultivaram-se: cenoura (Daucus carota 'Brasília'), repolho (Brassica oleracea var. capitata 'Astrus'), beterraba (Beta vulgaris 'Tall Top Early Wonder') e vagem-anã (Phaseolus vulgaris 'Alessa'). Em termos gerais, a solarização reduziu em 59% a reinfestação pela tiririca. Nas parcelas solarizadas, houve significativo incremento das produtividades de cenoura (28%), vagem (32%), beterraba (37%) e repolho (34%). A fixação biológica do nitrogênio, a julgar pela nodulação da vagem, não foi afetada pela solarização, mas a população de nematóides do solo sofreu considerável redução. A field experiment was carried out at Seropédica, state of Rio de Janeiro, Brazil, to evaluate the effects of soil solarization on purple nutsedge (Cyperus rotundus) weed population and on productivity of vegetable crops under organic cultivation. Solarization was accomplished by covering the soil surface with transparent polyethylene sheets (50 mum) for a period of 210 days. The mean temperature at 010 cm soil layer was about 23% higher than that of unsolarized plots. Following plastic removal the area was planted with carrot (Daucus carota 'Brasília'), cabbage (Brassica oleracea var. capitata 'Astrus'), garden beet (Beta vulgaris 'Tall Top Early Wonder'), and dwarf greenbean (Phaseolus vulgaris 'Alessa'). In general, soil solarization reduced purple nutsedge population by 59%. There was a significant increase in yields of carrot (28%), cabbage (34%), beet (37%), and greenbean (32%) when compared to unsolarized plots. Biological nitrogen fixation, as judged by greenbean nodulation, was not affected by solarization but the soil nematode population was considerably reduced.

The activities of NTPDase (EC 3.6.1.5, apyrase, CD39) and 5′-nucleotidase (EC 3.1.3.5, CD73) enzymes were analyzed in platelets from breast cancer patients. Initially, patients were compared in terms of length (years) of tamoxifen use. The following groups were studied: breast cancer patients who did not use tamoxifen, patients using tamoxifen for 1–48 months, patients using tamoxifen for 49–84 months, and controls (healthy subjects). Results demonstrated that adenosine triphosphate (ATP) hydrolysis was enhanced (F(3,114)=8.53; P

Submitted by MARCIA ROVADOSCHI (marciar@unifra.br) on 2018-08-22T12:19:00Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AdrianeCarvalhoCoelho.pdf: 2529788 bytes, checksum: d4346b2568476d4c6d7de7f0f5f09a70 (MD5) Made available in DSpace on 2018-08-22T12:19:00Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AdrianeCarvalhoCoelho.pdf: 2529788 bytes, checksum: d4346b2568476d4c6d7de7f0f5f09a70 (MD5) Previous issue date: 2018-07-06 Obesity is a nutritional and metabolic disorder that is in increasing prevalence worldwide. With its comorbidities, it integrates a relevant mortality index among chronic non-transmissible diseases of multifactorial etiology. Your prevention and treatment should involve a multidimensional look of care. Bariatric surgery is an option in the treatment of severe obese patients, however, it presents complex accessibility in the public health service in Brazil. In this context, an observational cross-sectional study was carried out to analyze the clinical profile, comorbidities and quality of life of obese patients awaiting bariatric surgery in a public hospital in southern Brazil. The convenience sample consisted of one hundred obese individuals who were able to undergo bariatric surgery through the Unified Health System and attended in a public hospital of the central region of Rio Grande do Sul, Brazil, in the year 2017. The data were collected in two moments: Consultation 1 - date of the participant in the bariatric surgery waiting list; and, Consultation 2 - on the day of application of the questionnaires to the same participants, still awaiting bariatric surgery. The clinical profile and comorbidities were analyzed by data from the medical records and characterization of the sample, quality of life through the questionnaire World Health Organization Quality of Life instrument-Bref; in the emotional aspects, the Beck Scales of Hopelessness, Anxiety and Depression were applied; the body image was obtained through the Brazilian Scale of Silhouettes for Adults. The results showed that the majority were female (77%), mean age 42.7 years, schooling prevalent elementary school (47%), average monthly family income less than two minimum wages. As for the occupation, only 56% worked. The majority (61%) were sedentary and had no dietary care (68%), with low intake of fruits, vegetables and high consumption of red meat. The mean waiting time of the sample for consultation at a referral service in bariatric surgery was 1.44 years, the oldest referral being 4.41 years. During this time, the average body mass index at the last visit was 49.63, being significantly higher than at the first visit. All had cardiovascular risk factors. The prevalent comorbidities were systemic arterial hypertension (67%), dyslipidemia (41%), type II diabetes (39%) and depression (48%). In the evaluation of the quality of life, the domain with the highest commitment was the physical one, followed by the psychological one. In the Beck Scales, traits of Anxiety predominated in the moderate and severe levels. In Beck's Scales of Hopelessness the quality of life was significantly affected in the psychological, social and general dimensions and, in the Beck Scales of Anxiety and Depression, the quality of life was affected in all dimensions, being that, the more serious the category of these inventories, the worse the quality of life judgment. Greater body image distortion was observed in females (31.2%) and as the perception of body image increased, there was deterioration in the conception of quality of life in all dimensions. Waiting time for bariatric surgery contributes to a significant increase in comorbidities, worsening of body image and quality of life. Low consumption of foods considered as protectors for non-transmissible chronic diseases was observed. It is necessary to expand the public policies of nutrition education and care throughout the network of care as a way to contribute to change this context. A obesidade é um distúrbio nutricional e metabólico que se encontra em crescente prevalência em todo mundo. Com suas comorbidades, integra um relevante índice de mortalidade entre as doenças crônicas não transmissíveis de etiologia multifatorial. Sua prevenção e tratamento deve envolver um olhar multidimensional de cuidado. A cirurgia bariátrica é uma opção no tratamento para obesos graves, no entanto, apresenta complexa acessibilidade no serviço público de saúde no Brasil. Neste contexto, foi realizado um estudo observacional de delineamento transversal, com o objetivo de analisar o perfil clínico, comorbidades e a qualidade de vida de pacientes obesos a espera de cirurgia bariátrica, em um hospital público do sul do Brasil. A amostra por conveniência foi constituída por cem indivíduos obesos aptos a se submeter à cirurgia bariátrica pelo Sistema Único de Saúde e assistidos em um hospital público da região central do Rio Grande do Sul, Brasil, no ano de 2017. A coleta dos dados realizou-se em dois momentos: Consulta 1 – data do participante na lista de espera da cirurgia bariátrica; e, Consulta 2 – no dia da aplicação dos questionários aos mesmos participantes, ainda em espera da cirurgia bariátrica. O perfil clínico e as comorbidades foram analisados por dados dos prontuários e caracterização da amostra, qualidade de vida através do questionário World Health Organization Quality of Life instrument-Bref; nos aspectos emocionais, foram aplicadas as Escalas de Beck de Desesperança, Ansiedade e Depressão; a imagem corporal foi obtida por meio da Escala Brasileira de Silhuetas para Adultos. Os resultados demonstraram que a maioria era do sexo feminino (77%), idade média de 42,7 anos, escolaridade prevalente o ensino fundamental (47%), renda mensal familiar média menor de dois salários mínimos. Quanto à ocupação, apenas 56% trabalhavam. Na sua maioria (61%) eram sedentários e não tinham cuidados dietéticos (68%), com baixa ingesta de frutas, legumes e verduras e alto consumo de carnes vermelhas. O tempo médio em espera da amostra para consulta em um serviço de referência em cirurgia bariátrica foi de 1,44 anos, sendo o encaminhamento mais antigo de 4,41 anos. No decorrer deste tempo o índice de massa corporal médio na última consulta foi de 49,63, sendo significativamente maior do que na primeira consulta. Todos apresentavam fatores de risco cardiovasculares. As comorbidades prevalentes foram hipertensão arterial sistêmica (67%), dislipidemia (41%), diabetes tipo II (39%) e depressão (48%).Na avaliação da qualidade de vida, o domínio com maior comprometimento foi o físico, seguido do psicológico. Nas Escalas de Beck, predominaram traços de Ansiedade nos níveis moderado e grave. Nas Escalas de Beck de Desesperança, a qualidade de vida foi, significativamente, afetada nas dimensões psicológica, social e geral e, nas Escalas de Beck de Ansiedade e Depressão, a qualidade de vida foi afetada em todas as dimensões, sendo que, quanto mais grave a categoria destes inventários, pior o juízo da qualidade de vida. Maior distorção da imagem corporal foi observada no sexo feminino (31,2%) e à medida que a percepção da imagem corporal aumentava, havia uma piora na concepção da qualidade de vida em todas as dimensões. O tempo de espera para a realização da cirurgia bariátrica contribui para um aumento significativo de comorbidades, com piora da imagem corporal e da qualidade de vida. Observou-se baixo consumo de alimentos considerados protetores para doenças crônicas não transmissíveis. Faz-se necessário ampliar as políticas públicas de educação nutricional e cuidados em toda a rede de atenção como forma de contribuir para mudar este contexto.