117 results on '"Maria Teresa Ricci"'
Search Results
2. Gynecological Cancers in Lynch Syndrome: A Comparison of the Histological Features with Sporadic Cases of the General Population
- Author
-
Valentina Elisabetta Bounous, Elisabetta Robba, Stefania Perotto, Barbara Pasini, Nicoletta Tomasi Cont, Maria Teresa Ricci, Antonino Ditto, Marco Vitellaro, Francesco Raspagliesi, and Nicoletta Biglia
- Subjects
Lynch syndrome ,endometrial cancer ,ovarian cancer ,mismatch repair genes ,Medicine - Abstract
Introduction: About 5% of endometrial cancers (ECs) are attributed to an inherited predisposition, for which Lynch syndrome (LS) accounts for the majority of cases. Women with LS have a 40–60% predicted lifetime risk of developing EC, in addition to a 40–80% lifetime risk of developing colorectal cancer and other cancers. In this population, the lifetime risk of developing ovarian cancer (OC) is 10–12%. Object: to compare the histopathological features of LS-associated EC and OC with sporadic cancers in order to evaluate whether there are differences in terms of age at diagnosis, site of occurrence in the uterus, histological type, stage at diagnosis, and tumor grading. Materials and methods: we compared data obtained from 96 patients with LS-associated gynecological cancers (82 with EC and 14 with OC) to a control group (CG) of 209 patients who developed sporadic EC, and a CG of 187 patients with sporadic OC. Results: The mean age at diagnosis of LS-associated EC and OC was much lower than in the control groups. In both groups with EC, the endometrioid histotype was the most frequently occurring histotype. However, among LS women there was a significantly higher incidence of clear cell tumors (11% versus 2.4% in the CG, p = 0.0001). Similar to the sporadic cancer cases, most of the LS-associated ECs presented at an early stage (89% of cases at FIGO I-II stage). In the LS group, the tumor frequently involved only the inner half of the endometrium (77% of cases, p < 0.01). In the LS group, 7.3% of ECs were localized to the lower uterine segment (LUS), whereas no cancer developed in the LUS in the CG. No serous OCs were diagnosed in the LS group (versus 45.5% in the CG, p = 0.0009). Most of the LS-associated OCs presented at an early stage (85% of cases at FIGO I-II stages, p < 0.01). Conclusion: LS-associated EC and OC seem to have peculiar features, occurring at a younger age and at an earlier stage. In LS, EC less frequently involves the outer half of the endometrium, with a more frequent occurrence in the LUS. The presence of clear cell EC was more frequently observed, whereas in OC, the predominant histotype was endometrioid.
- Published
- 2022
- Full Text
- View/download PDF
3. Prevalence and Management of Cancer of the Rectal Stump after Total Colectomy and Rectal Sparing in Patients with Familial Polyposis: Results from a Registry-Based Study
- Author
-
Gaia Colletti, Chiara Maura Ciniselli, Stefano Signoroni, Ivana Maria Francesca Cocco, Andrea Magarotto, Maria Teresa Ricci, Clorinda Brignola, Clara Bagatin, Laura Cattaneo, Andrea Mancini, Federica Cavalcoli, Massimo Milione, Paolo Verderio, and Marco Vitellaro
- Subjects
rectal stump cancer ,FAP ,hereditary syndrome ,colorectal surgery ,prevention ,total colectomy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: The balance between quality of life and colorectal cancer risk in familial adenomatous polyposis (FAP) patients is of primary importance. A cut-off of less than 30 polyps under 1 cm of diameter in the rectum has been used as an indication for performing ileo-rectal anastomosis (IRA) in terms of lower rectal cancer risk. This study aimed to assess clinical and surgical features of FAP patients who developed cancer of the rectal stump. Methods: This retrospective study included all FAP patients who underwent total colectomy/IRA from 1977 to 2021 and developed subsequent rectal cancer. Patients’ features were reported using descriptive statistics by considering the overall case series and within pre-specified classes of age (30 years) at first surgery. Results: Among the 715 FAP patients, 47 (6.57%, 95% confidence interval: 4.87; 8.65) developed cancer in the rectal stump during follow-up. In total, 57.45% of the population were male and 38.30% were proband. The median interval between surgery and the occurrence of rectal cancer was 13 years. This interval was wider in the youngest group (p-value: 0.012) than the oldest ones. Twelve patients (25.53%) received an endoscopic or minimally invasive resection. Amongst them, 61.70% were Dukes stage A cancers. Conclusions: There is a definite risk of rectal cancer after total colectomy/IRA; however, the time interval from the index procedure to cancer developing is long. Minimally invasive and endoscopic treatments should be the procedures of choice in patients with early stage cancers.
- Published
- 2022
- Full Text
- View/download PDF
4. A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results
- Author
-
Patrizia Pasanisi, Manuela Gariboldi, Paolo Verderio, Stefano Signoroni, Andrea Mancini, Licia Rivoltini, Massimo Milione, Enzo Masci, Chiara Maura Ciniselli, Eleonora Bruno, Alessandra Macciotta, Antonino Belfiore, Maria Teresa Ricci, Giuliana Gargano, Daniele Morelli, Giovanni Apolone, and Marco Vitellaro
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.
- Published
- 2019
- Full Text
- View/download PDF
5. La «Cortegiania» e la «Cortesana Filosofia»: B. Castiglione e B. Gracián
- Author
-
Maria Teresa Ricci
- Subjects
Baldassare Castiglione ,Cortigiano ,cortigiania ,Gracián ,filosofia cortesana ,Philology. Linguistics ,P1-1091 ,French literature - Italian literature - Spanish literature - Portuguese literature ,PQ1-3999 - Abstract
L’articolo stabilisce un confronto fra la cortigiania, ovvero la filosofia del comportamento raffinato dell’uomo cortese proposta dal testo Il cortigiano di Baldassare Castiglione, e la cortesana filosofia presente in tutta l’opera di Gracián. Questi due autori, che hanno vissuto in paesi e luoghi differenti, hanno dei principi filosofici, antropologici e religiosi molto diversi. Si distinguono dunque sia dal punto di vista letterario sia per il loro approccio teorico. Il primo offre un nuovo modello sociale di comportamento legato alla struttura particolare della corte all’inizio dell’epoca moderna; il secondo si propone esplicitamente di creare un «prodigio», un uomo «artificiale» che sappia far fronte alla realtà ingannevole, che sappia sopravvivere in un mondo ostile. Egli annuncia in un certo senso il passaggio dalla tradizionale società d’ordini, in cui ognuno ha sin dalla nascita il suo posto assicurato nella società, al mondo dell’«individualità astratta»
- Published
- 2013
- Full Text
- View/download PDF
6. Supplementary Table 1 from Preventive Anti-inflammatory Diet to Reduce Gastrointestinal Inflammation in Familial Adenomatous Polyposis Patients: A Prospective Pilot Study
- Author
-
Marco Vitellaro, Patrizia Pasanisi, Paolo Verderio, Massimo Milione, Giovanni Apolone, Giuliana Gargano, Laura Cattaneo, Elena Daveri, Maria Teresa Ricci, Alessandra Macciotta, Eleonora Bruno, Enzo Masci, Daniele Morelli, Licia Rivoltini, Andrea Mancini, Manuela Gariboldi, Stefano Signoroni, Chiara Maura Ciniselli, and Antonino Belfiore
- Abstract
Descriptive statistics of the primary and secondary endpoint measurements.
- Published
- 2023
7. Supplementary Figure 2 from Preventive Anti-inflammatory Diet to Reduce Gastrointestinal Inflammation in Familial Adenomatous Polyposis Patients: A Prospective Pilot Study
- Author
-
Marco Vitellaro, Patrizia Pasanisi, Paolo Verderio, Massimo Milione, Giovanni Apolone, Giuliana Gargano, Laura Cattaneo, Elena Daveri, Maria Teresa Ricci, Alessandra Macciotta, Eleonora Bruno, Enzo Masci, Daniele Morelli, Licia Rivoltini, Andrea Mancini, Manuela Gariboldi, Stefano Signoroni, Chiara Maura Ciniselli, and Antonino Belfiore
- Abstract
Boxplot reflecting the distribution of 15-PGDH expression at baseline (T0) and at six months (T2) according to the Aperio ScanScope Cytoplasm Algorithm V2. Each box indicates the 25th and 75th percentiles of the distribution. The horizontal line inside the box indicates the median and the whiskers indicate the extreme measured values; the mean value is represented by a black diamond.
- Published
- 2023
8. Supplementary Figure 1 from Preventive Anti-inflammatory Diet to Reduce Gastrointestinal Inflammation in Familial Adenomatous Polyposis Patients: A Prospective Pilot Study
- Author
-
Marco Vitellaro, Patrizia Pasanisi, Paolo Verderio, Massimo Milione, Giovanni Apolone, Giuliana Gargano, Laura Cattaneo, Elena Daveri, Maria Teresa Ricci, Alessandra Macciotta, Eleonora Bruno, Enzo Masci, Daniele Morelli, Licia Rivoltini, Andrea Mancini, Manuela Gariboldi, Stefano Signoroni, Chiara Maura Ciniselli, and Antonino Belfiore
- Abstract
Panel A-1: COX-2 IHC performed on normal FAP biopsies collected before the dietary intervention (T0) and after six months of diet (T2). Panel A-2: COX-2 IHC performed on adenoma FAP biopsies at T0 and T2. Panel B-1: COX-2 IHC performed on normal colon mucosa collected from surgery for sporadic colon cancer. Panel B-2: 15-PGDH IHC performed on normal colon mucosa collected from surgery for sporadic colon cancer.
- Published
- 2023
9. Supplementary Legends from Preventive Anti-inflammatory Diet to Reduce Gastrointestinal Inflammation in Familial Adenomatous Polyposis Patients: A Prospective Pilot Study
- Author
-
Marco Vitellaro, Patrizia Pasanisi, Paolo Verderio, Massimo Milione, Giovanni Apolone, Giuliana Gargano, Laura Cattaneo, Elena Daveri, Maria Teresa Ricci, Alessandra Macciotta, Eleonora Bruno, Enzo Masci, Daniele Morelli, Licia Rivoltini, Andrea Mancini, Manuela Gariboldi, Stefano Signoroni, Chiara Maura Ciniselli, and Antonino Belfiore
- Abstract
Supplementary Legends
- Published
- 2023
10. Thyroid findings in pediatric and adult patients with PTEN hamartoma tumor syndrome: A retrospective analysis, and literature review
- Author
-
Donatella Milani, Alessia Dolci, Ilaria Muller, Maria Angela Pavesi, Letterio Runza, Elisabetta Kuhn, Federica Natacci, Bernard Peissel, Maria Teresa Ricci, Luca Despini, Gianluca Tomasello, Francesco Grossi, Ornella Garrone, and Donatella Gambini
- Subjects
Endocrinology ,Endocrinology, Diabetes and Metabolism - Published
- 2023
11. De Novo Germline Partial Deletion of The MLH1 Gene in a 26-Year-Old Woman with Synchronous Colorectal Adenocarcinoma and Neuroendocrine Tumor of the Appendix
- Author
-
Clorinda Brignola, Sara Volorio, Giovanna De Vecchi, Daniela Zaffaroni, Valentina Dall'Olio, Frederique Mariette, Domenico Sardella, Fabio Capra, Stefano Signoroni, Emanuele rausa, Marco Vitellaro, Valeria Pensotti, and Maria Teresa Ricci
- Published
- 2023
12. L'ideale dell’otium e la modernità
- Author
-
Maria Teresa Ricci
- Abstract
L’articolo propone una breve storia della nozione di “otium” dall’antichità ai nostri giorni. Mostra come nella Greciaantica la vita oziosa viene considerata onorevole e come invece vengono condannati il “lavoro”, inteso nel senso di assenza dilibertà, e la ricerca della ricchezza come fine a se stessa. Queste idee riappaiono nel corso della storia, ad esempio, nella trattatistica del comportamento che fiorisce nel Rinascimento, negli ideali cortigiani, cosi’ come tra le classi marginali della società.
- Published
- 2021
13. O ideal do otium e a modernidade
- Author
-
Maria Teresa Ricci
- Abstract
O artigo propõe uma breve história da noção de “otium” desde a Antiguidade até os nossos dias. Mostra como, na Grécia antiga, a vida ociosa é considerada honorável e o trabalho é condenado, entendido no sentido de ausência de liberdade e de busca de riqueza como um fim em si mesma. Essas ideias reaparecem no curso da história, por exemplo, na tratadística do comportamento que floresce no Renascimento, nos ideais cortesãos, assim como entre as classes marginais da sociedade.
- Published
- 2021
14. Long-term benefits of exclusive human milk diet in small for gestational age neonates: a systematic review of the literature
- Author
-
Federica Pagano, Emanuele Gaeta, Francesca Morlino, Maria Teresa Riccio, Maurizio Giordano, and Giuseppe De Bernardo
- Subjects
Breastfeeding ,Newborn ,Nutrition ,Donor milk ,Outcome ,IUGR ,Pediatrics ,RJ1-570 - Abstract
Abstract Evidence about feeding practices’ consequences in small for gestational age newborns is not well established because they are less likely to initiate and continue breastfeeding than other newborns. Our aim was to study current knowledge about the benefits of exclusive human milk diet after 2 years of age in small for gestational age newborns. A systematic review of the literature was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline criteria. Pubmed and Scopus were searched for studies published from databases inception until June 2, 2023. Included articles were analysed and synthesised. Risk of bias and level of evidence assessments were performed. They were enrolled small for gestational age newborns fed by breastfeeding, breast milk or donor milk. The systematic review included 9 articles which were related to 4 health domains: neurodevelopment, cardiovascular, somatic growth and bone mineralization and atopy. Extracted data support a beneficial effect of breastfeeding on these outcomes. Better quality of evidence and longer follow-up are needed.
- Published
- 2024
- Full Text
- View/download PDF
15. Integration and qualification of the Mini-EUSO telescope on board the ISS
- Author
-
Francesca Capel, Eva Reali, Enzo Reali, T. Napolitano, L. Marcelli, Pavel Klimov, Lech Wiktor Piotrowski, Maria Teresa Ricci, A. Franceschi, Alexander S. Belov, Alberto Franceschi, P. Klimov, Marco Ricci, M. Casolino, F. Capel, Andrei S. Belov, Piergiorgio Picozza, L.W. Piotrowski, P. Picozza, Marco Casolino, and G. Cambiè
- Subjects
Physics ,Photomultiplier ,business.industry ,Detector ,FOS: Physical sciences ,Photon counting ,law.invention ,Telescope ,Silicon photomultiplier ,Optics ,law ,International Space Station ,Satellite ,Image sensor ,business ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) - Abstract
Mini-EUSO is a new space-based experiment designed primarily to observe showers that develop in atmosphere due to the interaction between molecular nitrogen and Ultra High Energy Cosmic particles (above 1021 eV) crossing by. It belongs to the JEM-EUSO program, which includes several past experiments all devoted to develop new larger size satellite detectors like K-EUSO and POEMMA for future UHEC Rays study from space. Mini-EUSO is a multiwavelenght telescope launched on August 2019 with the unmanned Soyuz MS-14 rocket to the International Space Station and currently operating on board the Russian Zvezda module, facing a UV-transparent window watching Earth in Nadir direction. The telescope optics comprise a main detection system employing two double-sided Fresnel lenses focusing UV (300–400 nm) light onto an array of 36 Hamamatsu Multi-Anode PhotoMultiplier Tubes, each of 64 channels for a total of 2304 pixels working in single photon counting mode, providing a wide field of view (44°) correpsonding to a ground area of 263 x 263 km2 with a highly fast time resolution up to few microseconds. Mini-EUSO includes also multiple ancillary sensors such as visible (400–780 nm) and NIR (1500–1600 nm) cameras covering a wide range of radiation wavelenght as well as a 64 channels Multi-Pixel Photon Counter Silicon PhotoMultiplier array which will increase the Technology Readiness Level of this ultrafast imaging sensor. Beside the primary objective, the mission aims to study different event such as meteoroids, Transient Luminous Event, search for Strange Quark matter and thanks to its space-time resolution is capable to provide UV Earth maps over the surface covered during ISS orbits. In this work we will present the detector integration, the qualification measurements on ground and some preliminary data.
- Published
- 2022
16. The neglected role of preimplantation genetic testing for Lynch syndrome
- Author
-
Chiara Dallagiovanna, Francesca Filippi, Alessandra Riccaboni, Paola Vigano’, Fabio Martinelli, Edgardo Somigliana, Maria Teresa Ricci, and Marco Vitellaro
- Subjects
Monogenic disorders ,Preimplantation genetic testing for monogenic/single-gene defects (PGT-M) ,BRCA ,Hereditary cancer syndromes ,Lynch syndrome ,Preimplantation genetic testing ,Reproductive Medicine ,Obstetrics and Gynecology ,Settore MED/40 - Ginecologia e Ostetricia ,Developmental Biology - Abstract
Preimplantation genetic testing for monogenic/single-gene disorders (PGT-M) is a procedure employed in the field of assisted reproductive technology to avoid the transmission of genetic diseases to the offspring. Hereditary cancer syndromes represent a diffuse and accepted indication for PGT-M, but take-up differs among the different disorders. Its use is markedly lower for the genes causing Lynch syndrome compared with the breast cancer type 1 or 2 susceptibility genes (BRCA1/2), despite the similar prevalence and severity of the two conditions. Reasons to explain this difference have not been explored. First, Lynch syndrome may be more frequently undiagnosed compared with hereditary breast and ovarian cancer syndrome. In addition, the different take-up may be due to different patient perceptions of the conditions and of the management options. Finally, this distinct attitude may depend on the awareness and sensibility of the professionals caring for affected patients. The authors' considerations are, however, speculative, and specific studies aimed at disentangling the causes of the different receptions of PGT-M are warranted to understand how to tackle this gap. In the meantime, we believe that empowerment regarding PGT-M of all individuals with hereditary cancer syndromes, including Lynch syndrome, is ethically due, and plead for a more active involvement of caregivers.
- Published
- 2022
17. Risk factors for metachronous colorectal cancer in Lynch syndrome patients: a registry-based observational mono-institutional study cohort
- Author
-
Maria Teresa Ricci, Alberto Morabito, Lucio Bertario, Andrea Mancini, Marco Vitellaro, Guglielmo Niccolò Piozzi, and Stefano Signoroni
- Subjects
Adult ,Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,Population ,Kaplan-Meier Estimate ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Registries ,education ,Aged ,Retrospective Studies ,education.field_of_study ,business.industry ,Proportional hazards model ,Cancer ,Neoplasms, Second Primary ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,Primary tumor ,digestive system diseases ,Lynch syndrome ,Colorectal surgery ,MutS Homolog 2 Protein ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cohort ,Female ,Surgery ,Colorectal Neoplasms ,MutL Protein Homolog 1 ,business - Abstract
Risk factors for metachronous colorectal cancer (mCRC) in Lynch Syndrome (LS) patients are essential for colorectal cancer (CRC) treatment strategy to perform not only a curative but also preventive surgery. The aim of this study was to evaluate the risk factors for mCRC development in LS patients to define the patient subset that may benefit an extended curative and preventive surgical resection. Patient’s clinical history, oncological, molecular and follow-up were collected retrospectively from the Hereditary Digestive Tumors Registry at the National Cancer Institute of Milan. The age-related cumulative risk of mCRC was calculated using the Kaplan–Meier method. Factors significantly associated with mCRC were analyzed with a Cox regression model. Overall and specific competitive risks were also calculated. In a total of 1346 CRC patients, 159 (11.8%) developed a mCRC after a mean follow-up of 138 months from the primary tumor. The independent risk factors reported by a multivariate analysis were: pathogenetic variants in MLH1 and MSH2 (HR 2.96 and 1.91, respectively) and history of colorectal adenomas (HR 1.54); whereas female sex and extended surgery were protective (HR 0.59 and 0.79, respectively). Among a high-risk population for CRC, in particular LS, an extended surgery may be considered in CRC patients with specific risk factors (MLH1 or MSH2 germline pathogenic variants, history of colorectal adenomas) to reduce the risk of mCRC development.
- Published
- 2020
18. Lynch syndrome-related non-endometrioid endometrial cancer: analysis of outcomes
- Author
-
Antonino Ditto, Giorgio Bogani, Francesco Raspagliesi, Valentina Chiappa, Maria Grazia Tibiletti, Massimo Milione, Fabio Ghezzi, Biagio Paolini, Ileana Carnevali, Maria Teresa Ricci, Marco Vitellaro, Viola Liberale, and Ferdinando Murgia
- Subjects
Adult ,medicine.medical_specialty ,endometrial neoplasms ,Disease-Free Survival ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Lynch syndrome II ,Internal medicine ,medicine ,Humans ,Survival rate ,Aged ,Retrospective Studies ,030304 developmental biology ,0303 health sciences ,business.industry ,Endometrial cancer ,Case-control study ,Obstetrics and Gynecology ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,Lynch syndrome ,DNA-Binding Proteins ,Survival Rate ,uterine neoplasms ,MutS Homolog 2 Protein ,Oncology ,Case-Control Studies ,030220 oncology & carcinogenesis ,Population study ,Lynch Syndrome II ,Female ,MutL Protein Homolog 1 ,Ovarian cancer ,business ,Carcinoma, Endometrioid - Abstract
ObjectiveWomen with Lynch syndrome have a risk up to 40–60% of developing endometrial cancer, which is higher than their risk of developing colorectal or ovarian cancer. To date, no data on the outcomes of patients with Lynch syndrome diagnosed with non-endometrioid endometrial cancer are available. The goal of this study was to evaluate the outcome of patients with Lynch syndrome diagnosed with non-endometrioid endometrial cancer.MethodsData from consecutive patients diagnosed with Lynch syndrome and with a histological diagnosis of non-endometrioid endometrial cancer were retrospectively collected in two referral institutes in Italy. A case–control comparison (applying a propensity matching algorithm) was performed in order to compare patients with proven Lynch syndrome and controls. Inclusion criteria were: (a) histologically-proven endometrial cancer; (b) detection of a germline pathogenic variant in one of the MMR genes; (c) adequate follow-up. Only carriers of pathogenic or likely pathogenic variants (ie, class 5 and 4 according to the InSiGHT classification) were included in the study. Survival outcomes were assessed using KaplanMeier and Cox models.ResultsOverall, 137 patients with Lynch syndrome were collected. Mean patient age was 49.2 (10.9) years. Genes involved in the Lynch syndrome included MLH1, MSH2, and MSH6 in 43%, 39%, and 18% of cases, respectively. The study population included 27 patients with non-endometrioid endometrial cancer, who were matched 1:2 with patients with sporadic cancers using a propensity matching algorithm. After a median follow-up of 134 months (range 1–295), 2 (7.4%) of the 27 patients developed recurrent disease (3 and 36 months) and subsequently died of disease (7 and 91 months). Patients diagnosed with Lynch syndrome experienced better disease-free survival (HR 7.86 (95% CI 1.79 to 34.5); p=0.006) and overall survival (HR 5.33 (95% CI 1.18 to 23.9); p=0.029) than controls.ConclusionsNon-endometrioid endometrial cancer occurring in patients with Lynch syndrome might be associated with improved oncologic outcomes compared with controls. Genetic/molecular profiling should be investigated in order to better understand the mechanism underlying the prognosis.
- Published
- 2019
19. Gardner-associated fibroma of the neck: role of a multidisciplinary evaluation for familial adenomatous polyposis diagnosis
- Author
-
Marco Vitellaro, Davide Biasoni, Ivana Maria Francesca Cocco, Maria Teresa Ricci, Stefano Signoroni, Stefano Chiaravalli, Guglielmo Niccolò Piozzi, and Paola Collini
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Adolescent ,Rectum ,Fibroma ,030218 nuclear medicine & medical imaging ,Familial adenomatous polyposis ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Gardner Syndrome ,Genetic Testing ,Germ-Line Mutation ,business.industry ,General Medicine ,Colonoscopy ,medicine.disease ,Dermatology ,medicine.anatomical_structure ,Oncology ,Adenomatous Polyposis Coli ,030220 oncology & carcinogenesis ,Lifetime risk ,business - Abstract
Introduction: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant disorder characterized by the development of multiple adenomas in the colon and rectum with a lifetime risk of 80%–100% to develop colorectal cancer if undetected or untreated. Gardner-associated fibroma (GAF) is a rare, benign soft tissue lesion with uncertain pathogenesis. GAF is generally associated with FAP in its clinical variant, called Gardner syndrome (GS). Case Description: A 16-year-old boy with no comorbidities and no significant medical history was referred to the Unit of Hereditary Digestive Tract Tumours, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, for genetic counselling after surgical removal of a right anterior cervical paramedian fibroma. The histopathology on the specimen led to the diagnosis of GAF. He had no family history for colorectal cancer or gastrointestinal polyposis and denied any gastrointestinal symptoms. Physical examination showed a small frontal osteoma and colonoscopy showed the presence of multiple small sessile polyps (>100 polyps, diameter Conclusions: GAF may represent a sentinel sign of FAP, preceding gastrointestinal symptoms and endoscopic findings. A careful multidisciplinary approach is determinant for correct and early diagnosis of FAP.
- Published
- 2021
20. Graça e Sprezzatura em Baldassar Castiglione
- Author
-
Maria Teresa Ricci, Cristiane Maria Rebello Nascimento, Centre d'études supérieures de la Renaissance UMR 7323 (CESR), and Ministère de la Culture et de la Communication (MCC)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[SHS.LITT]Humanities and Social Sciences/Literature ,Geography, Planning and Development ,Management, Monitoring, Policy and Law ,Castiglione ,Grâce ,ComputingMilieux_MISCELLANEOUS ,[SHS]Humanities and Social Sciences - Abstract
Partindo da análise da etimologia da palavra “graça”, a autora analisa a teoria de Castiglione, condensada na frase “quem tem graça, é grato”, que indica tanto um sentido ativo, quanto um sentido passivo da palavra “graça”. Para receber a graça de seu príncipe, o nobre cortesão deve ser gracioso. A “graça”, portanto, torna-se um ornamento e uma estratégia. A “graça” nasce de uma “regra universal”: evitar afetação e demonstrar certa indiferença – sprezzatura. Sprezzatura, que implica disprezzo, desdém, é dissimulação da arte e similação de natureza. É o produto de uma longa “fadiga” que deve ficar completamente escondida. A “graça” pode ser, deste modo, resumida no oxímoro: arte sem arte.
- Published
- 2019
21. Duodenal adenomas and cancer in MUTYH-associated polyposis: an international cohort study
- Author
-
Andrew Latchford, A. Alonso Sanchez, Patrick M. Lynch, Matthew Mort, Joanna J Hurley, Maria Teresa Ricci, E. Meuser, Marco Vitellaro, Hannah West, A. Backman, Yann Parc, Susan K. Clark, M. R. Aznárez, Frederik J. Hes, Sunil Dolwani, O. Vinet, H. Leon Brito, Maureen E. Mork, Chrystelle Colas, M. Navarro Garcia, S. Gonzalez Romero, Sarah-Jane Walton, Hala Jundi, Gabriel Capellá, S. Kelland, Zeinab Ghorbanoghli, K van der Tuin, Hans F. A. Vasen, Julian R. Sampson, Jan Björk, Evelien Dekker, Jean-Christophe Saurin, Eduardo Vilar, Laura E. Thomas, M. Gonn, Maartje Nielsen, Clinical sciences, Medical Genetics, Gastroenterology and Hepatology, APH - Quality of Care, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
- Subjects
Adult ,Male ,medicine.medical_specialty ,Duodenum ,Gastroenterology ,DNA Glycosylases ,Familial adenomatous polyposis ,Adenomatous Polyps ,Young Adult ,Duodenal Neoplasms ,Internal medicine ,Prevalence ,medicine ,Humans ,Genetics(clinical) ,Prospective Studies ,Intestinal Mucosa ,Endoscòpia ,Polyposis ,Càncer ,Duodenoscopy ,Aged ,Cancer ,Aged, 80 and over ,Hepatology ,Spigelman Stage ,business.industry ,MUTYH-Associated Polyposis ,Endoscopy ,Middle Aged ,medicine.disease ,digestive system diseases ,Estudi de casos ,Female ,Case studies ,business ,Cohort study - Abstract
Although duodenal adenomas and cancer appear to occur significantly less frequently in autosomal recessive MUTYH-associated polyposis (MAP) than in autosomal dominant familial adenomatous polyposis (FAP),1 current guidelines recommend similar endoscopic surveillance for both disorders.2-4 This involves gastro-duodenoscopy starting at 25 to 35 years of age and repeated at intervals determined by Spigelman staging based on the number, size, histological type and degree of dysplasia of adenomas, and by ampullary staging. Case reports of duodenal cancers in MAP suggest that they may develop in the absence of advanced Spigelman stage benign disease and even without coexisting adenomas.1 Recent molecular analyses suggest thatMAPduodenal adenomashave a higher mutational burden than FAP adenomas and are more likely to harbor oncogenic drivermutations, such as those in KRAS.5 These apparent differences in the biology and natural history of duodenal polyposis in FAP and MAP challenge the assumption that the same surveillance should be applied in both conditions.
- Published
- 2021
22. Medulloblastoma and familial adenomatous polyposis: Good prognosis and good quality of life in the long‐term?
- Author
-
Maura Massimino, Stefano Signoroni, Luna Boschetti, Luisa Chiapparini, Alessandra Erbetta, Veronica Biassoni, Elisabetta Schiavello, Andrea Ferrari, Filippo Spreafico, Monica Terenziani, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Maria Teresa Ricci, Laura Cattaneo, Giovanna Gattuso, Francesca Romana Buttarelli, Francesca Gianno, Evelina Miele, Geraldina Poggi, and Marco Vitellaro
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Vincristine ,Adolescent ,Adenomatous polyposis coli ,Pancreatoblastoma ,Familial adenomatous polyposis ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Family history ,Cerebellar Neoplasms ,Child ,Medulloblastoma ,biology ,business.industry ,Disease Management ,Hematology ,Lomustine ,Prognosis ,medicine.disease ,Carboplatin ,Pedigree ,Adenomatous Polyposis Coli ,chemistry ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Quality of Life ,biology.protein ,Female ,business ,030215 immunology ,medicine.drug - Abstract
Introduction Mutations of the APC (adenomatous polyposis coli) gene correlate mainly with familial adenomatous polyposis (FAP), but can occasionally be pathogenic for medulloblastoma (MBL) wingless-related integration site (WNT) subtype, the course of which has only recently been described. Methods We retrieved all patients with documented germline APC mutations and a diagnosis of MBL to examine their outcome, late effects of treatment, and further oncological events. Results Between 2007 and 2016, we treated six patients, all with a pathogenic APC variant mutation and all with MBL, classic histotype. None had metastatic disease. All patients were in complete remission a median 65 months after treatment with craniospinal irradiation at 23.4 Gy, plus a boost on the posterior fossa/tumor bed up to 54 Gy, followed by cisplatin/carboplatin, lomustine, and vincristine for a maximum of eight courses. Five of six diagnostic revised MRI were suggestive of the WNT molecular subgroup typical aspects. Methylation profile score (in two cases) and copy number variation analysis (chromosome 6 deletion in two cases) performed on four of six retrieved samples confirmed WNT molecular subgroup. Four out of six patients had a positive family history of FAP, while gastrointestinal symptoms prompted its identification in the other two cases. Four patients developed other tumors (desmoid, MELTUMP, melanoma, pancreatoblastoma, thyroid Tir3) from 5 to 7 years after MBL. Discussion Our data confirm a good prognosis for patients with MBL associated with FAP. Patients' secondary tumors may or may not be related to their syndrome or treatment, but warrant adequate attention when planning shared guidelines for these patients.
- Published
- 2021
23. Definition and management of colorectal polyposis not associated with APC/MUTYH germline pathogenic variants: AIFEG consensus statement
- Author
-
Emanuele Damiano Luca Urso, Maurizio Ponz de Leon, Marco Vitellaro, Guglielmo Niccolò Piozzi, Quoc Riccardo Bao, Aline Martayan, Andrea Remo, Vittoria Stigliano, Cristina Oliani, Emanuela Lucci Cordisco, Salvatore Pucciarelli, Guglielmina Nadia Ranzani, Alessandra Viel, Francesca Adami, Elisa Alducci, Lucia Amadori, Valentina Arcangeli, Luisa Balestrino, Daniela Barana, Lucio Bertario, Bernardo Bonanni, Stefania Boni, Pierluigi Bullian, Fiorella Carbonardi, Ileana Carnevali, Paola Castelli, Francesco Celotto, Giulia Cini, Gino Crivellari, Duilio Della Libera, Anastasia Dell'elice, Maria Digennaro, Alessandra D'urso, Antonella Fabretto, Daniele Fanale, Irene Feroce, Daniela Furlan, Paola Ghiorzo, Mara Giacché, Milena Gusella, Barbara Liserre, Isabella Mammi, Stefania Massuras, Daniela Mazzà, Eleonora Mollica, Alberto Morabito, Giorgia Nardo, Flavia Palermo, Elena Panizza, Margherita Patruno, Monica Pedroni, Valeria Grazia Maria Pensotti, Guglielmo Niccolo Piozzi, Simonetta Pozzi, Silvia Presi, Marta Puzzono, Mila Ravegnani, Maria Teresa Ricci, Luca Roncucci, Giovanni Battsita Rossi, Elena Maria Sala, Lupe Sanchez Mete, Daniele Sandonà, Stefania Sciallero, Davide Serrano, Stefano Signoroni, Francesca Spina, Monica Taborelli, Gianluca Tedaldi, Maria Grazia Tibiletti, Silvia Tognazzo, Gianluca Tolva, Cristina Maria Concetta Trovato, Daniela Turchetti, Dora Varvara, Caterina Vivanet, Stefania Zovato, Raffaella Alessia Zuppardo, Urso E.D.L., Ponz de Leon M., Vitellaro M., Piozzi G.N., Bao Q.R., Martayan A., Remo A., Stigliano V., Oliani C., Lucci Cordisco E., Pucciarelli S., Ranzani G.N., Viel A., Adami F., Alducci E., Amadori L., Arcangeli V., Balestrino L., Barana D., Bertario L., Bonanni B., Boni S., Bullian P., Carbonardi F., Carnevali I., Castelli P., Celotto F., Cini G., Crivellari G., Libera D.D., Dell'elice A., Digennaro M., D'urso A., Fabretto A., Fanale D., Feroce I., Furlan D., Ghiorzo P., Giacche M., Gusella M., Liserre B., Mammi I., Massuras S., Mazza D., Mollica E., Morabito A., Nardo G., Palermo F., Panizza E., Patruno M., Pedroni M., Pensotti V.G.M., Pozzi S., Presi S., Puzzono M., Ravegnani M., Ricci M.T., Roncucci L., Rossi G.B., Sala E.M., Mete L.S., Sandona D., Sciallero S., Serrano D., Signoroni S., Spina F., Taborelli M., Tedaldi G., Tibiletti M.G., Tognazzo S., Tolva G., Trovato C.M.C., Turchetti D., Varvara D., Vivanet C., Zovato S., and Zuppardo R.A.
- Subjects
Oncology ,medicine.medical_specialty ,Gastrointestinal tumors ,Colorectal cancer ,Surgical Management ,Colorectal polyposis ,Germline ,03 medical and health sciences ,Cancer Genetic ,0302 clinical medicine ,MUTYH ,Internal medicine ,medicine ,Cancer Genetics ,Polyposis coli ,Hepatology ,Pathogenic mutation ,business.industry ,Colorectal polyposis not associated with APC/MUTYH mutation ,Polyposis management guideline ,Gastroenterology ,Expert consensus ,Endoscopic surveillance ,medicine.disease ,Consensus development conference ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,business - Abstract
An expert consensus panel convened by the Italian Association for Inherited and Familial Gastrointestinal Tumors (Associazione Italiana per lo Studio della Familiarita ed Ereditarieta dei Tumori Gastrointestinali, AIFEG) reviewed the literature and agreed on a number of position statements regarding the definition and management of polyposis coli without an identified pathogenic mutation on the APC or MUTYH genes, defined in the document as NAMP (non-APC/MUTYH polyposis).
- Published
- 2021
24. Medulloblastoma and Familial Adenomatous Polyposis: good prognosis and good quality of life in the long-term?
- Author
-
Francesca R. Buttarelli, Veronica Biassoni, Luca Bergamaschi, Maura Massimino, Geraldina Poggi, Francesca Gianno, Stefano Signoroni, Andrea C. Ferrari, Stefano Chiaravalli, Laura Cattaneo, Maria Teresa Ricci, Marco Vitellaro, Nadia Puma, Luna Boschetti, Elisabetta Schiavello, and Giovanna Gattuso
- Subjects
Oncology ,Medulloblastoma ,medicine.medical_specialty ,Vincristine ,biology ,Adenomatous polyposis coli ,business.industry ,Pancreatoblastoma ,Lomustine ,medicine.disease ,Carboplatin ,Familial adenomatous polyposis ,chemistry.chemical_compound ,chemistry ,Internal medicine ,medicine ,biology.protein ,Family history ,business ,medicine.drug - Abstract
Introduction. Mutations of the APC (adenomatous polyposis coli) gene correlate mainly with familial adenomatous polyposis (FAP), but can occasionally be pathogenic for medulloblastoma (MBL) WNT subtype as well, the course of which has only recently been described. Methods. We retrospectively retrieved all patients with documented germline APC mutations and a centrally-reviewed diagnosis of MBL to examine the outcome of their MBL, late effects of its treatment, and further oncological events. Results. Between 2007-2016 we diagnosed and treated 6 patients, all with a pathogenic APC variant mutation, who all had MBL, classic histotype. None had metastatic disease. All patients were in complete remission a median 65 months after treatment with craniospinal irradiation at 23.4 Gy, plus a boost on the posterior fossa/tumor bed up to 54 Gy, followed by cisplatin/carboplatin, lomustine and vincristine for a maximum of 8 courses. Five of 6 diagnostic revised MRI were suggestive of the WNT molecular subgroup typical aspects. Four of 6 patients had a positive family history of FAP, while gastrointestinal symptoms prompted its identification in the other 2 cases. Four patients had developed other tumors (desmoid, MELTUMP, melanoma, pancreatoblastoma, thyroid Tir3) from 5 to 7 years after MBL. Discussion. Our data confirm a good prognosis for patients with MBL associated with FAP. Patients’ secondary tumors may or may not be related to their syndrome or treatment, but warrant adequate attention when planning shared guidelines for these patients.
- Published
- 2020
25. APC-associated polyposis conditions
- Author
-
Maria Teresa Ricci
- Subjects
Cancer Research ,Oncology ,Attenuated familial adenomatous polyposis ,business.industry ,Genetics ,medicine ,Cancer research ,Hematology ,medicine.disease ,business ,Familial adenomatous polyposis - Published
- 2020
26. Long-term survival between total colectomy versus proctocolectomy in patients with FAP: a registry-based, observational cohort study
- Author
-
Savino Occhionorelli, Marco Vitellaro, Stefano Signoroni, Ilaria Ardoino, Elia Biganzoli, Maria Teresa Ricci, Enzo Malvicini, and Lucio Bertario
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Familial adenomatous polyposis ,NO ,Young Adult ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Long term survival ,medicine ,Humans ,In patient ,Young adult ,ileal pouch–anal anastomosis ,ileorectal anastomosis ,long-term survival ,prophylactic surgery ,Colectomy ,Aged ,Proportional Hazards Models ,Proportional hazards model ,business.industry ,Proctocolectomy ,Anastomosis, Surgical ,Proctocolectomy, Restorative ,Rectum ,General Medicine ,Middle Aged ,medicine.disease ,Prophylactic Surgery ,Surgery ,Italy ,Oncology ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Colorectal Neoplasms ,business ,Cohort study - Abstract
Background: The best surgical choice for patients with familial adenomatous polyposis (FAP) is still debated. No prospective trials have been carried out to evaluate the pros and cons of the recommended procedures: total colectomy (ileorectal anastomosis [IRA]) vs restorative proctocolectomy (ileal pouch–anal anastomosis [IPAA]). The aim of this study was to provide a basis for tailored precision surgery in patients with FAP. Methods: We conducted a retrospective review of patients with FAP who underwent surgery and were registered in a dedicated database in Milan, Italy. Twenty-year survival related to surgical approach and prognostic factors were investigated using a Cox regression model. Results: A total of 925 patients underwent surgery between 1947 and 2015: 340 (36.8%) IPAA and 585 (63.2%) IRA. Colorectal cancer (CRC) at surgery was diagnosed in 28.6% of patients and a pathogenic APC variant was identified in 88%. During a median follow-up of 129 months, 150 patients died. The survival probability was significantly higher in the IRA than the IPAA group: 0.82 vs 0.75 (hazard ratio [HR] 0.6, 95% confidence interval [CI] 0.42–0.84). Multivariable regression modeling adjusted for propensity scores showed a similar difference, although no longer significant. Multivariable analysis indicated as independent risk factors CRC (HR 4.68, 95% CI 3.04–7.20) and age at surgery (HR 1.03, 95% CI 1.02–1.06). Among patients without cancer, the main risk factor for shorter survival was older age (HR 1.06, 95% CI 1.04–1.09). Conclusion: The study confirms excellent long-term results of surgical approaches with IRA and IPAA, suggesting that the best surgical choice may be an individually and clinically tailored approach, preferably at a young age.
- Published
- 2020
27. Short‐term and long‐term outcomes after preventive surgery in adolescent patients with familial adenomatous polyposis
- Author
-
Paolo Verderio, Maura Massimino, Chiara Maura Ciniselli, Stefano Signoroni, Maria Teresa Ricci, Anna Cardani, Guglielmo Niccolò Piozzi, Davide Biasoni, Irene Vecchi, Andrea Mancini, Marco Vitellaro, Andrea Magarotto, and Andrea Ferrari
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Colorectal cancer ,Adenocarcinoma ,Familial adenomatous polyposis ,Young Adult ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Risk Factors ,medicine ,Humans ,Child ,Retrospective Studies ,business.industry ,Retrospective cohort study ,Hematology ,Prognosis ,medicine.disease ,Prophylactic Surgery ,Surgery ,Bowel obstruction ,Adenomatous Polyposis Coli ,Oncology ,Dysplasia ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Female ,Laparoscopy ,business ,Follow-Up Studies ,030215 immunology ,Abdominal surgery - Abstract
Background APC gene pathogenic variants are characterized by a lifetime risk of nearly 100% to develop a colorectal carcinoma. International guidelines suggest a prophylactic surgery in the second decade. Methods A descriptive analysis was performed evaluating a surgical series of adolescent patients with familial adenomatous polyposis (FAP) enrolled in the prospectively maintained hereditary polyposis registry. Results Thirty-eight adolescent patients (median age 16 years; range, 7-19) underwent laparoscopic prophylactic surgery. APC gene pathogenic variants were detected in all patients, and six patients were proband. No patients were converted to open surgery. Median postoperative stay was five days (4-16). Early postoperative complications were one dural puncture and one anastomotic leakage. Regarding late complications, we observed one patient having small bowel obstruction 56 months after surgery. Pathological reports showed one patient with pTis adenocarcinoma in two separate sites; 33 patients with low-grade dysplasia, four with high-grade dysplasia. One patient developed a desmoid tumor 37 months after surgery. After a median follow-up of 40.5 months, no patients died or had a second abdominal surgery because of cancer in rectal stump. Conclusions Rectal sparing surgery was the first choice in the major respect of patients' quality of life. Laparoscopic prophylactic surgery for FAP is well accepted from adolescents. It represents a safe option due to the low incidence of post-surgical desmoids and quick postoperative recovery.
- Published
- 2019
28. Management of an Obese Patient with Familial Adenomatous Polyposis: Surgical Implication of Biliopancreatic Diversion and Total Colectomy
- Author
-
Stefano Signoroni, Maria Teresa Ricci, Guglielmo Niccolò Piozzi, Marco Vitellaro, and Lucio Bertario
- Subjects
Total Colectomy ,medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,General surgery ,MEDLINE ,Medicine ,Surgery ,business ,medicine.disease ,Biliopancreatic Diversion ,Familial adenomatous polyposis - Published
- 2019
29. Ready, get set, go: Fast preoperative genetic diagnosis is the present future in Lynch syndrome surgical strategy
- Author
-
Stefano Signoroni, Marco Vitellaro, Guglielmo Niccolò Piozzi, and Maria Teresa Ricci
- Subjects
Set (abstract data type) ,Surgical strategy ,Hepatology ,business.industry ,Gastroenterology ,medicine ,Medical emergency ,Genetic diagnosis ,medicine.disease ,business ,Lynch syndrome - Published
- 2019
30. The EUSO@Turlab Project: Tests of Mini-EUSO Engineering Model
- Author
-
A. Franceschi, L. Marcelli, G. Contino, Maria Teresa Ricci, A. Djakonow, Marco Mignone, Lech Wiktor Piotrowski, A. Murashov, J. Szabelski, M.E Bertaina, Naoto Sakaki, Pavel Klimov, W. Marszał, Matteo Battisti, F. Bisconti, Alexander S. Belov, A. Poroshin, K. Shinozaki, S. Blin-Bondil, Daniele Gardiol, Francesca Capel, Francesco Fenu, Enzo Reali, M. Przybylak, A. Cellino, E. Parizot, P. Picozza, M. I. Panasyuk, G. Suino, M. Bertaina, S. Turriziani, Toshikazu Ebisuzaki, Federico Fausti, Marco Casolino, Claudio Fornaro, Guillaume Prévôt, G. Cambiè, I. Churilo, P. Gorodetzky, F. Kajino, M. Traïche, F. Cafagna, Y. Takizawa, Z. Plebaniak, G. Osteria, Christer Fuglesang, R. Bonino, T. Napolitano, Rossella Caruso, G. Cotto, Organisation de Micro-Électronique Générale Avancée (OMEGA), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), JEM-EUSO, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
- Subjects
Brightness ,business.industry ,Detector ,Cosmic ray ,Field of view ,Rotating tank ,law.invention ,Telescope ,law ,Environmental science ,Focal surface ,Aerospace engineering ,business ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,Space debris - Abstract
International audience; The TurLab facility is a laboratory, equipped with a 5 m diameter and 1 m depth rotating tank, located in the Physics Department of the University of Turin. Originally, it was mainly built to study systems of different scales where rotation plays a key role in the fluid behaviour such as in atmospheric and oceanic flows. In the past few years the TurLab facility has been used to perform experiments related to the observation of Extreme Energy Cosmic Rays (EECRs) from space using the fluorescence technique. For example, in the case of the JEM-EUSO mission, where the diffuse night brightness and artificial light sources can vary significantly in time and space inside the Field of View of the telescope. The Focal Surface of Mini-EUSO Engineering Model (Mini-EUSO EM) with the level 1 (L1) and 2 (L2) trigger logics implemented in the Photo-Detector Module (PDM) has been tested at TurLab. Tests related to the possibility of using an EUSO-like detector for other type of applications such as Space Debris (SD) monitoring and imaging detector have also been pursued. The tests and results obtained within the EUSO@TurLab Project on these different topics are presented.
- Published
- 2019
31. Development, technical validation, and clinical application of a multigene panel for hereditary gastrointestinal cancer and polyposis
- Author
-
Maria Teresa Ricci, Sara Volorio, Stefano Signoroni, Paolo Mariani, Frederique Mariette, Domenico Sardella, Marco Vitellaro, and Valeria Pensotti
- Subjects
0301 basic medicine ,Adult ,Male ,Cancer Research ,Adolescent ,Genetic counseling ,Genetic Counseling ,Bioinformatics ,Polymorphism, Single Nucleotide ,Sensitivity and Specificity ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Gastrointestinal cancer ,Genetic Testing ,Child ,Aged ,Gastrointestinal Neoplasms ,Aged, 80 and over ,business.industry ,Reproducibility of Results ,General Medicine ,Middle Aged ,medicine.disease ,030104 developmental biology ,Oncology ,Adenomatous Polyposis Coli ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Introduction: Recent advances in technology and research are rapidly changing the diagnostic approach to hereditary gastrointestinal cancer (HGIC) syndromes. Although the practice of clinical genetics is currently transitioning from targeted criteria-based testing to multigene panels, important challenges remain to be addressed. The aim of this study was to develop and technically validate the performance of a multigene panel for HGIC. Methods: CGT-colon-G14 is an amplicon-based panel designed to detect single nucleotide variants and small insertions/deletions in 14 well-established or presumed high-penetrance genes involved in HGIC. The assay parameters tested were sensitivity, specificity, accuracy, and inter-run and intra-run reproducibility. Performance and clinical impact were determined using 48 samples of patients with suspected HGIC/polyposis previously tested with the targeted approach. Results: The CGT-colon-G14 panel showed 99.99% accuracy and 100% inter- and intra-run reproducibility. Moreover, panel testing detected 1 actionable pathogenic variant and 16 variants with uncertain clinical impact that were missed by the conventional approach because they were located in genes not previously analyzed. Conclusion: Introduction of the CGT-colon-G14 panel into the clinic could provide a higher diagnostic yield than a step-wise approach; however, results may not always be straightforward without the implementation of new genetic counseling models.
- Published
- 2019
32. Cosmic ray electrons and positrons over decade with the PAMELA experiment
- Author
-
P. Spillantini, O. Adriani, W. Menn, F. Cafagna, V. Bonvicini, A. Bruno, S. Yu. Krutkov, Yu. I. Stozhkov, M. Bongi, M. Merge, L. Marcelli, Maria Teresa Ricci, A. Vacchi, V. V. Mikhailov, S. V. Koldashov, P. Carlson, S. O. Kleymenova, Sergey Koldobskiy, Riccardo Munini, G. C. Barbarino, G. A. Bazilevskaya, D. Campana, C. De Santis, André Monaco, Marco Casolino, G. Zampa, Beatrice Panico, M. Simon, P. Picozza, Yu. T. Yurkin, V. Di Felice, Mark Pearce, S. B. Ricciarini, N. Zampa, V. V. Malakhov, Mirko Boezio, P. Papini, Alexey Leonov, E. Vannuccini, G. I. Vasiliev, R. Sparvoli, Nicola Mori, Roberto Bellotti, A. N. Kvashnin, Matteo Martucci, A. M. Galper, E. Mocchiutti, A. V. Karelin, S. A. Voronov, G. Castellini, A. G. Mayorova, E. A. Bogomolov, G. Osteria, Mikhailov, V. V., Adriani, O., Barbarino, G., Bazilevskaya, G. A., Bellotti, R., Boezio, M., Bogomolov, E. A., Bongi, M., Bonvicini, V., Bruno, A., Cafagna, F. S., Campana, D., Carlson, P., Casolino, M., Castellini, G., De Santis, C., Di Felice, V., Galper, A. M., Karelin, A. V., Kleymenova, S. O., Koldashov, S. V., Koldobskiy, S., Krutkov, S. Y., Kvashnin, A. N., Leonov, A. A., Malakhov, V. V., Marcelli, L., Martucci, M., Mayorova, A. G., Menn, W., Merge, M., Mocchiutti, E., Monaco, A., Mori, N., Munini, R., Osteria, G., Papini, P., Panico, B., Pearce, M., Picozza, P., Ricci, M., Ricciarini, S. B., Simon, M., Sparvoli, R., Spillantini, P., Stozhkov, Y. I., Vacchi, A., Vannuccini, E., Vasiliev, G. I., Voronov, S. A., Yurkin, Y. T., Zampa, G., and Zampa, N.
- Subjects
Physics ,History ,Earth's orbit ,Antiparticle ,Settore FIS/04 ,Astrophysics::High Energy Astrophysical Phenomena ,Astronomy ,Cosmic ray ,COSMIC RAYS ,Electron ,Computer Science Applications ,Education ,SOLAR MINIMA ,Positron ,Physics::Space Physics ,Satellite ,WIDE ENERGY RANGE - Abstract
The PAMELA experiment has measured cosmic ray particles and antiparticles fluxes at Earth orbit from June 2006 till January 2016 onboard the Resurs-DK1 satellite. Measurements were carried out during the solar minimum of 23 solar cycle with negative polarity A < 0 of heliospheric magnetic field till the beginning of 24 cycle with positive polarity A > 0. In this paper, the results of observations of electron and positron fluxes are presented in wide energy range from several hundreds MeVs till several TeVs These measurements provide important information to study cosmic ray sources and propagation in Galaxy and heliosphere.
- Published
- 2019
33. A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results
- Author
-
Daniele Morelli, Alessandra Macciotta, Maria Teresa Ricci, Stefano Signoroni, Licia Rivoltini, A. Belfiore, Massimo Milione, Enzo Masci, Chiara Maura Ciniselli, Manuela Gariboldi, Patrizia Pasanisi, Andrea Mancini, Giovanni Apolone, Marco Vitellaro, Eleonora Bruno, Paolo Verderio, and Giuliana Gargano
- Subjects
0301 basic medicine ,Male ,Mediterranean diet ,Colorectal cancer ,Pilot Projects ,Mediterranean ,Diet, Mediterranean ,0302 clinical medicine ,Quality of life ,prevention ,Surveys and Questionnaires ,Epidemiology ,Prospective Studies ,Prospective cohort study ,2. Zero hunger ,biology ,adenomas ,Middle Aged ,hereditary tumors ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prophylactic Surgery ,3. Good health ,Oncology ,Adenomatous Polyposis Coli ,030220 oncology & carcinogenesis ,Female ,low-inflammatory diet ,Colorectal Neoplasms ,Research Article ,Adult ,medicine.medical_specialty ,Adolescent ,Adenomatous polyposis coli ,lcsh:RC254-282 ,Familial adenomatous polyposis ,03 medical and health sciences ,Young Adult ,Internal medicine ,medicine ,microbiota ,Humans ,Aged ,Inflammation ,030109 nutrition & dietetics ,business.industry ,FAP ,biomarkers ,medicine.disease ,Diet ,Complementary and alternative medicine ,quality of life ,Quality of Life ,biology.protein ,business - Abstract
Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.
- Published
- 2019
- Full Text
- View/download PDF
34. The POEMMA (Probe of Extreme Multi-Messenger Astrophysics) mission
- Author
-
A. Neronov, Francesco Fenu, Mark Christl, S. Mackovjak, Alessandro Liberatore, J. S. Perkins, P. Bertone, Mauricio Bustamante, F. Bisconti, T. Paul, E. Hays, James H. Adams, Guillaume Prévôt, R. D. Young, E. G. Judd, C. Guepin, Patrick J. Reardon, F. W. Stecker, Roberto Aloisio, K. Shinozaki, Angela V. Olinto, M. E. Bertaina, Luis A. Anchordoqui, Mary Hall Reno, Tonia M. Venters, John F. Krizmanic, E. Kuznetsov, E. Parizot, Julie McEnery, J. W. Mitchell, Foteini Oikonomou, M. Unger, Marco Casolino, Johannes Eser, I. DeMitri, Douglas Bergman, J.F. Soriano, R. Diesing, L. R. Wiencke, F. Sarazin, Maria Teresa Ricci, A. N. Otte, Y. Takizawa, Ralf Ulrich, Austin Cummings, Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
- Subjects
Astrophysics and Astronomy ,media_common.quotation_subject ,Astrophysics::High Energy Astrophysical Phenomena ,satellite ,FOS: Physical sciences ,Cosmic ray ,7. Clean energy ,01 natural sciences ,High Energy Physics - Experiment ,law.invention ,High Energy Physics - Experiment (hep-ex) ,law ,0103 physical sciences ,ultraviolet ,optical ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,surface ,Cherenkov ,ddc:530 ,cosmic radiation: UHE ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,010306 general physics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Cherenkov radiation ,media_common ,Physics ,astro-ph.HE ,High Energy Astrophysical Phenomena (astro-ph.HE) ,COSMIC cancer database ,hybrid ,010308 nuclear & particles physics ,hep-ex ,formation ,Astrophysics::Instrumentation and Methods for Astrophysics ,Astronomy ,Photometer ,messenger ,Sky ,Focal surface ,fluorescence ,Neutrino ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,Ultrashort pulse ,Particle Physics - Experiment ,astro-ph.IM - Abstract
The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) is designed to observe cosmic neutrinos (CNs) above 20 PeV and ultra-high energy cosmic rays (UHECRs) above 20 EeV over the full sky. The POEMMA mission calls for two identical satellites flying in loose formation, each comprised of a 4-meter wide field-of-view (45 degrees) Schmidt photometer. The hybrid focal surface includes a fast (1 ${\mu}$s) ultraviolet camera for fluorescence observations and an ultrafast (10 ns) optical camera for Cherenkov observations. POEMMA will provide new multi-messenger windows onto the most energetic events in the universe, enabling the study of new astrophysics and particle physics at these otherwise inaccessible energies., Comment: 8 pages, 6 figures, presented in 36th International Cosmic Ray Conference (Madison). arXiv admin note: substantial text overlap with arXiv:1907.06217
- Published
- 2019
35. Mini-EUSO engineering model: tests in open-sky condition
- Author
-
Christer Fuglesang, S. Turriziani, Toshikazu Ebisuzaki, Federico Fausti, Lech Wiktor Piotrowski, Z. Plebaniak, J. Szabelski, G. Osteria, A. Djakonow, Naoto Sakaki, P. Gorodetzky, W. Marszał, G. Cotto, A. Belov, A. Murashov, A. Cellino, G. Suino, Matteo Battisti, Marco Casolino, Claudio Fornaro, Daniele Gardiol, Dario Barghini, Y. Takizawa, P. Picozza, Francesca Capel, G. Cambiè, I. Churilo, S. Blin-Bondil, T. Napolitano, F. Bisconti, K. Shinozaki, Hiroko Miyamoto, A. Poroshin, Maria Teresa Ricci, Enzo Reali, A. Franceschi, L. Marcelli, Guillaume Prévôt, Francesco Fenu, F. Kajino, E. Parizot, M. Traïche, M. Przybylak, F. Cafagna, Marco Mignone, M. E. Bertaina, Pavel Klimov, M. I. Panasyuk, Organisation de Micro-Électronique Générale Avancée (OMEGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), JEM-EUSO, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
- Subjects
media_common.quotation_subject ,Astrophysics::High Energy Astrophysical Phenomena ,Night sky ,FOS: Physical sciences ,Cosmic ray ,law.invention ,Atmosphere ,Telescope ,Planet ,law ,International Space Station ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,media_common ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Meteoroid ,Astrophysics::Instrumentation and Methods for Astrophysics ,Astronomy ,13. Climate action ,Sky ,Physics::Space Physics ,Astrophysics::Earth and Planetary Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] - Abstract
Mini-EUSO is a UV telescope that will look downwards to the Earth's atmosphere onboard the International Space Station. With the design of the ultra-high energy cosmic ray fluorescence detectors belonging to the JEM-EUSO program, it will make the first UV map of the Earth by observing atmospheric phenomena such as transient luminous events, sprites and lightning, as well as meteors and bioluminescence from earth. Diffused light from laser shots from the ground, which mimic the fluorescence light emitted by Nitrogen molecules when extensive air showers pass through the atmosphere, can be used to verify the capability of this kind of detector to observe ultra-high energy cosmic rays. To validate the electronics and the trigger algorithms developed for Mini-EUSO, a scaled down version of the telescope with 1:9 of the original focal surface and a lens of 2.5 cm diameter has been built. Tests of the Mini-EUSO engineering model have been made in laboratory and in open sky condition. In this paper, we report results of observations of the night sky, which include the detection of stars, meteors, a planet and a rocket body reflecting the sunlight. Interesting results of the observation of city lights are also reported., Comment: presented at the 36th ICRC (Madison, WI; 2019)
- Published
- 2019
- Full Text
- View/download PDF
36. Lynch Syndrome
- Author
-
Maria Teresa Ricci
- Subjects
Cancer Research ,Oncology ,Genetics ,Hematology - Published
- 2018
37. Conduct Literature for and about Women in Italy, 1470–1900: Prescribing and Describing Life. Helena Sanson and Francesco Lucioli, eds. Women and Gender in Italy (1500–1900) 1. Paris: Classiques Garnier, 2016. 438 pp. €32
- Author
-
Maria Teresa Ricci
- Subjects
History ,Literature and Literary Theory ,Visual Arts and Performing Arts - Published
- 2017
38. Performance of tumor testing for Lynch syndrome identification in patients with colorectal cancer: A retrospective single-center study
- Author
-
Alberto Morabito, Ileana Carnevali, Maria Teresa Ricci, Lucio Bertario, Federica Perrone, Marco Vitellaro, Massimo Milione, Maria Grazia Tibiletti, Anna Maria Chiaravalli, Valeria Pensotti, and Stefano Signoroni
- Subjects
Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Single Center ,DNA Mismatch Repair ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,In patient ,Genetic Testing ,Germ-Line Mutation ,Retrospective Studies ,business.industry ,Microsatellite instability ,General Medicine ,Middle Aged ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,Immunohistochemistry ,digestive system diseases ,Lynch syndrome ,Endometrial Neoplasms ,Italy ,030220 oncology & carcinogenesis ,Cohort ,Identification (biology) ,Female ,Microsatellite Instability ,business ,Colorectal Neoplasms - Abstract
Objective: To investigate the performance of tumor testing approaches in the identification of Lynch syndrome (LS) in a single-center cohort of people with colorectal cancer (CRC). Methods: A retrospective analysis of data stored in a dedicated database was carried out to identify patients with CRC suspected for LS who were referred to Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, between 1999 and 2014. The sensitivity and specificity of immunohistochemistry (IHC) for mismatch repair (MMR) proteins and microsatellite instability (MSI) analysis (alone or combined) were calculated with respect to the presence of causative MMR germline variants. Results: A total of 683 patients with CRC suspected for LS were identified. IHC results of MMR protein analysis and MSI were assessed in 593 and 525 CRCs, respectively, while germline analysis was performed in 418 patients based on the IHC or MSI test result and/or clinical features. Univariate and multivariate analysis revealed a significant correlation of pathogenic MMR germline variants with all clinicopathologic features including Amsterdam criteria, presence of endometrial cancer, CRC site, age at onset, stage, and grade. The highest odds ratio values were observed for IHC and MSI (17.1 and 8.8, respectively). The receiver operating characteristic curve and area under the curve values demonstrated that IHC alone or combined with other clinicopathologic parameters was an excellent test for LS identification. Conclusions: This study confirms the effectiveness of tumor testing to identify LS among patients with CRC. Although IHC and MSI analysis were similarly effective, IHC could be a better strategy for LS identification as it is less expensive and more feasible.
- Published
- 2018
39. Le Dialogo della bella creanza delle donne (1539) d’Alessandro Piccolomini et le Dialogo dell’istituzione delle donne (1545) de Lodovico Dolce
- Author
-
Maria Teresa Ricci
- Published
- 2018
40. Time dependence of the helium flux measured by PAMELA
- Author
-
Matteo Martucci, M. Simon, Sergey Koldobskiy, G. C. Barbarino, V. V. Mikhailov, P. Carlson, Alexey Leonov, D. Campana, Roberto Bellotti, A. M. Galper, S. Y. Krutkov, G. Zampa, Beatrice Panico, A. G. Mayorov, R. Sparvoli, Marco Casolino, A. N. Kvashnin, Riccardo Munini, O. Adriani, E. Mocchiutti, F. Cafagna, W. Menn, Nicola Mori, S. A. Voronov, Yu. T. Yurkin, G. Castellini, Massimo Bongi, E. A. Bogomolov, P. Picozza, G. I. Vasilyev, P. Spillantini, C. De Santis, V. V. Malakhov, Maria Teresa Ricci, S. V. Koldashov, Mark Pearce, S. B. Ricciarini, P. Papini, E. Vannuccini, L. Marcelli, A. Vacchi, M. Merge, V. Bonvicini, A. Bruno, Y. I. Stozhkov, André Monaco, A. V. Karelin, G. Osteria, N. Zampa, Mirko Boezio, and G. A. Bazilevskaya
- Subjects
Physics ,Proton ,Astrophysics::High Energy Astrophysical Phenomena ,Phase (waves) ,Flux ,chemistry.chemical_element ,Cosmic ray ,Astrophysics ,Solar cycle ,chemistry ,QUIET ,Physics::Space Physics ,Heliosphere ,Helium - Abstract
The last solar cycle has presented a peculiarly long quiet phase with consequent minimum modulation conditions for cosmic rays. The proton and electron spectra were measured from July 2006 to December 2009 by PAMELA experiment, providing fundamental information about the transport and modulation of cosmic rays inside the heliosphere. These studies allow to obtain a more complete description of the cosmic radiation. In this picture the time dependence of the helium spectrum become very important to constrain parameters of the actual solar modulation model. The crucial point for this analysis is the selection of a dataset of helium events which ensure high statistics with a very low contamination. In this paper the definition of the selection criteria for helium events with data taken from July 2006 to June 2014 by PAMELA experiment is reported.
- Published
- 2017
41. Search for a positron anisotropy with PAMELA experiment
- Author
-
Mark Pearce, S. B. Ricciarini, A. V. Karelin, E. Vannuccini, D. Campana, P. Spillantini, G. Osteria, Marco Casolino, V. Di Felice, G. Zampa, Beatrice Panico, Sergey Koldobskiy, G. C. Barbarino, Riccardo Munini, N. De Simone, R. Sparvoli, E. Mocchiutti, Alfonso Monaco, Maria Teresa Ricci, F. Cafagna, Matteo Martucci, V. Bonvicini, Nicola Mori, O. Adriani, Y. I. Stozhkov, M. Merge, S. V. Koldashov, Y. T. Yurkin, V. V. Malakhov, S. Y. Krutkov, W. Menn, L. Marcelli, V. V. Mikhailov, A. M. Galper, A. Vacchi, S. Bottai, N. Zampa, M. Simon, G. A. Bazilevskaya, A. G. Mayorov, Valerio Formato, A. Bruno, A. A. Leonov, Valentina Scotti, Roberto Bellotti, M. Bongi, P. Picozza, A. N. Kvashnin, Mirko Boezio, S. A. Voronov, Ritabrata Sarkar, G. I. Vasilyev, E. A. Bogomolov, Per Carlson, Ugo Giaccari, G. Castellini, F. Palma, C. De Santis, and C. De Donato
- Subjects
Nuclear physics ,Physics ,Positron ,Earth's magnetic field ,Pulsar ,Astrophysics::High Energy Astrophysical Phenomena ,Isotropy ,Physics::Accelerator Physics ,General Earth and Planetary Sciences ,High Energy Physics::Experiment ,Electron ,Anisotropy ,General Environmental Science - Abstract
The PAMELA experiment has been collecting data since 2006; its results indicate a rise in the positron fraction with respect to the sum of electrons and positrons in the cosmic-ray (CR) spectrum above 10 GeV. This excess can be due to additional sources, as SNRs or pulsars, which can lead to an anisotropy in the local CR positron, detectable from current experiments. We report on the analysis on spatial distributions of positron events collected by PAMELA, taking into account also the geomagnetic field effects. No significant deviation from the isotropy has been observed.
- Published
- 2015
42. The large-scale anisotropy with the PAMELA calorimeter
- Author
-
Y. T. Yurkin, N. De Simone, Valentina Scotti, P. Spillantini, M. Simon, V. V. Malakhov, S. Bottai, A. V. Karelin, L. Marcelli, A. Vacchi, V. Di Felice, Riccardo Munini, W. Menn, A. Bruno, Per Carlson, F. Palma, R. Sparvoli, G. Zampa, E. Mocchiutti, Beatrice Panico, G. Osteria, S. Y. Krutkov, M. Merge, D. Campana, N. Zampa, G. A. Bazilevskaya, A. M. Galper, Mirko Boezio, V. Bonvicini, Y. I. Stozhkov, P. Picozza, Maria Teresa Ricci, Roberto Bellotti, Marco Casolino, F. Cafagna, S. V. Koldashov, M. Bongi, A. N. Kvashnin, André Monaco, A. A. Leonov, O. Adriani, R. Carbone, V. V. Mikhailov, Sergey Koldobskiy, G. C. Barbarino, Mark Pearce, S. B. Ricciarini, P. Papini, E. Vannuccini, Matteo Martucci, A. G. Mayorov, C. De Santis, C. De Donato, G. Castellini, S. A. Voronov, E. A. Bogomolov, Nicola Mori, Ritabrata Sarkar, G. I. Vasilyev, and Valerio Formato
- Subjects
Physics ,Scale (ratio) ,Calorimeter (particle physics) ,Astrophysics::High Energy Astrophysical Phenomena ,Phase (waves) ,Cosmic ray ,Astrophysics ,Physics::Geophysics ,Nuclear physics ,Dipole ,Amplitude ,Equatorial coordinate system ,General Earth and Planetary Sciences ,Anisotropy ,General Environmental Science - Abstract
The large-scale anisotropy (or the so-called star-diurnal wave) has been studied using the calorimeter of the space-born experiment PAMELA. The cosmic ray anisotropy has been obtained for the Southern and Northern hemispheres simultaneously in the equatorial coordinate system for the time period 2006–2014. The dipole amplitude and phase have been measured for energies 1–20 TeV n-1.
- Published
- 2015
43. Old Age in Castiglione’s The Book of the Courtier
- Author
-
Maria Teresa Ricci
- Published
- 2017
44. Measurements of electron and positron fluxes below the geomagnetic cutoff by the PAMELA magnetic spectrometer
- Author
-
Sergey Koldashov, S. Bottai, E. Mocchiutti, G. A. Bazilevskaya, M. Simon, Yu. T. Yurkin, A. Bruno, Y. I. Stozhkov, Paolo Papini, P. Spillantini, G. Castellini, M. Merge, A. N. Kvashnin, Alexey Leonov, F. Cafagna, N. Zampa, Mark Pearce, S. B. Ricciarini, Sergey Koldobskiy, G. C. Barbarino, V. Di Felice, D. Campana, E. Vannuccini, R. Sparvoli, S. Y. Krutkov, Giovanni Bonvicini, V. V. Mikhailov, Marco Casolino, V. V. Malakhov, André Monaco, P. Carlson, P. Picozza, Maria Teresa Ricci, O. Adriani, G. Zampa, Beatrice Panico, L. Marcelli, A. Vacchi, S. A. Voronov, E. A. Bogomolov, Mirko Boezio, C. De Donato, Matteo Martucci, C. De Santis, A. G. Mayorov, Riccardo Munini, G. I. Vasilyev, Nicola Mori, Yu. V. Mikhailova, Roberto Bellotti, A. M. Galper, Massimo Bongi, A. V. Karelin, and G. Osteria
- Subjects
Physics ,Rigidity (electromagnetism) ,Earth's magnetic field ,Positron ,Spectrometer ,Astrophysics::High Energy Astrophysical Phenomena ,Electron ,Trapping ,Astrophysics ,Secondary electrons ,South Atlantic Anomaly - Abstract
We present a measurements of electron and positron fluxes below the geomagnetic cutoff rigidity in wide energy range from ~50 MeV to several GeVs by the PAMELA magnetic spectrometer. The instrument was launched on June 15th 2006 on-board the Resurs-DK satellite on low orbit with 70 degrees inclination and altitude between 350 and 600 km. Features of spatial distributions of secondary electrons and positrons in the near Earth space, including the South Atlantic Anomaly, were investigated in terms of lifetime and geographical origin. The separation in stably trapped , long lifetime quasi-trapped, and short lifetime albedo components was performed on base of back tracing procedure in geomagnetic field. A significant difference in relative abundance of positrons with respect to electrons is seen for the stable trapped and the quasi-trapped populations what pointing out on different trapping mechanism of those populations.
- Published
- 2017
45. A novel APC promoter 1B deletion shows a founder effect in Italian patients with classical familial adenomatous polyposis phenotype
- Author
-
Maria Teresa Ricci, Marco Vitellaro, Viviana Gismondi, Raefa Abou Khouzam, Guglielmina Nadia Ranzani, Orsetta Zuffardi, Monica Marabelli, Annalisa Vetro, Valentina Rea, and Liliana Varesco
- Subjects
0301 basic medicine ,Adult ,Male ,Cancer Research ,Adolescent ,Adenomatous polyposis coli ,Adenomatous Polyposis Coli Protein ,Germline ,Familial adenomatous polyposis ,03 medical and health sciences ,0302 clinical medicine ,Germline mutation ,Genetics ,medicine ,Humans ,Allele ,Promoter Regions, Genetic ,Germ-Line Mutation ,biology ,Point mutation ,Middle Aged ,medicine.disease ,Founder Effect ,Pedigree ,030104 developmental biology ,Phenotype ,Adenomatous Polyposis Coli ,Italy ,030220 oncology & carcinogenesis ,biology.protein ,Female ,Multiple Adenomatous Polyps ,Gene Deletion ,Founder effect - Abstract
Familial adenomatous polyposis is a Mendelian syndrome in which germline loss-of-function mutations of APC are associated with multiple adenomatous polyps of the large bowel, a multiplicity of extracolonic features, and a high lifetime risk of colorectal cancer. Different APC germline mutations have been identified, including sequence changes, genomic rearrangements, and expression defects. Recently, very rare families have been associated with constitutive large deletions encompassing the APC-5' regulatory region, while leaving the remaining gene sequence intact; the regulatory region contains a proximal and a distal promoter, called 1A and 1B, respectively. We identified a novel deletion encompassing promoter 1B in a large Italian family that manifested polyposis in three of the six branches descending from a founding couple married in 1797. By combining different molecular approaches on both DNA and RNA, we precisely mapped this deletion (6,858 bp in length) that proved to be associated with APC allele silencing. The finding of the same deletion in two additional polyposis families pointed to a founder mutation in Italy. Deletion carriers from the three families all showed a “classical” polyposis phenotype. To explore the molecular mechanisms underlying promoter deletions, we performed an in silico analysis of the breakpoints of 1A and 1B rearrangements so far reported in the literature; moreover, to decipher genotype-phenotype correlations, we critically reviewed current knowledge on deletions vs. point mutations in the APC-5' regulatory region. This article is protected by copyright. All rights reserved.
- Published
- 2017
46. Sharp increasing of positron to electron fluxes ratio below 2 GV measured by the PAMELA
- Author
-
Alfonso Monaco, A. N. Kvashnin, M. Merge, V. V. Mikhailov, P. Carlson, A. G. Mayorov, G. I. Vasiliev, R. Sparvoli, N. De Simone, G. Zampa, Beatrice Panico, M. Simon, N. Zampa, Sergey Koldashov, G. A. Bazilevskaya, Yu. T. Yurkin, C. De Santis, Yu. I. Stozhkov, V. V. Malakhov, S. Yu. Krutkov, P. Picozza, Roberto Bellotti, Mark Pearce, S. B. Ricciarini, F. Palma, A. M. Galper, P. Papini, Giuseppe Osteria, E. Vannuccini, Matteo Martucci, S. A. Koldobsky, E. Mocchiutti, F. Cafagna, A. V. Karelin, Mirko Boezio, D. Campana, S. Bottai, Maria Teresa Ricci, S. A. Voronov, Marco Casolino, C. De Donato, Nicola Mori, E. A. Bogomolov, Riccardo Munini, M. Bongi, P. Spillantini, O. Adriani, W. Menn, V. Di Felice, V. Bonvicini, G. C. Barbarino, G. Castellini, L. Marcelli, A. Vacchi, A. Bruno, Alexey Leonov, Mikhailov, V. V., Adriani, O., Barbarino, G., Bazilevskaya, G. A., Bellotti, R., Boezio, M., Bogomolov, E. A., Bongi, M., Bonvicini, V., Bottai, S., Bruno, A., Cafagna, F. S., Campana, D., Carlson, P., Casolino, M., Castellini, G., De Donato, C., De Santis, C., De Simone, N., Di Felice, V., Galper, A. M., Karelin, A. V., Koldashov, S. V., Koldobsky, S., Krutkov, S. Y., Kvashnin, A. N., Leonov, A. A., Malakhov, V. V., Marcelli, L., Martucci, M., Mayorov, A. G., Menn, W., Merge, M., Mocchiutti, E., Monaco, A., Mori, N., Munini, R., Osteria, G., Papini, P., Palma, F., Panico, B., Pearce, M., Picozza, P., Ricci, M., Ricciarini, S. B., Simon, M., Sparvoli, R., Spillantini, P., Stozhkov, Y. I., Vacchi, A., Vannuccini, E., Vasiliev, G. I., Voronov, S. A., Yurkin, Y. T., Zampa, G., and Zampa, N.
- Subjects
Physics ,Settore FIS/01 ,History ,Antiparticle ,PAMELA detector ,Spectrometer ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics::Instrumentation and Methods for Astrophysics ,Polar orbit ,Cosmic ray ,Astrophysics ,Electron ,Cosmology ,Electrons ,Magnetic polarity ,Orbits ,Positrons ,Computer Science Applications ,Education ,law.invention ,Physics and Astronomy (all) ,Positron ,law ,Physics::Space Physics ,Satellite ,Astrophysics::Earth and Planetary Astrophysics - Abstract
Magnetic spectrometer PAMELA was launched onboard a satellite Resurs-DK1 into low-Earth polar orbit with altitude 350-600 km to study cosmic ray antiparticle fluxes in a wide energy range from ~ 100 MeV to hundreds GeV. This paper presents the results of observations of temporal variations of the positron and electron fluxes in the 2006-2015. The ratio of the positron and electron fluxes below 2 GV shows sharp increasing since 2014 due to changing of the polarity of the solar magnetic field.
- Published
- 2017
47. Solar modulation of galactic cosmic rays during 2006-2015 based on PAMELA and ARINA data
- Author
-
Alfonso Monaco, S. Bottai, A. G. Mayorov, P. Picozza, M. Merge, Maria Teresa Ricci, Sergey Koldobskiy, G. C. Barbarino, P. Yu. Naumov, A. V. Karelin, P. Spillantini, Alexey Leonov, R. Sparvoli, Mark Pearce, S. B. Ricciarini, Nicola Mori, S. A. Voronov, M. Simon, P. Papini, E. Vannuccini, N. Zampa, G. A. Bazilevskaya, L. Marcelli, E. A. Bogomolov, G. Osteria, D. Campana, A. Vacchi, Laura Rossetto, V. V. Malakhov, Yu. T. Yurkin, A. Bruno, V. V. Mikhailov, O. Adriani, M. A. Mayorova, Marco Casolino, Roberto Bellotti, A. M. Galper, Matteo Martucci, W. Menn, G. I. Vasilyev, V. Di Felice, A. A. Kvashnin, Mirko Boezio, G. Castellini, G. Zampa, Beatrice Panico, Riccardo Munini, C. De Santis, S. A. Rodenko, F. Cafagna, M. Bongi, Per Carlson, V. Bonvicini, Y. Stozhkov, Sergey Aleksandrin, E. Mocchiutti, and S. V. Koldashov
- Subjects
Settore FIS/01 ,Physics ,History ,Scintillation ,PAMELA detector ,Spectrometer ,Cosmic rays ,Cosmology ,Magnetic polarity ,Modulation ,Solar energy ,Spectrometers Galactic cosmic rays ,Magnetic spectrometers ,Solar activity ,Solar magnetic fields ,Solar modulation ,Transient periods ,Astrophysics::High Energy Astrophysical Phenomena ,Cosmic ray ,Astrophysics ,Computer Science Applications ,Education ,Magnetic field ,law.invention ,Physics and Astronomy (all) ,law ,Physics::Space Physics ,Nuclear Experiment - Abstract
Solar modulation of galactic protons with energies from 50 MeV up to dozens of GeV during July '06 - January '16 studied based on a data of the magnetic spectrometer PAMELA and scintillation spectrometer ARINA. This period is interesting because it covers the end of 23rd and current 24th cycles of solar activity, including the abnormally long transient period and change of the polarity of solar magnetic field. © Published under licence by IOP Publishing Ltd.
- Published
- 2017
48. Type and frequency of MUTYH variants in Italian patients with suspected MAP: A retrospective multicenter study
- Author
-
Viviana Gismondi, Michele Quaia, Davide Bondavalli, Sara Miccoli, Filomena Mazzei, Aline Martayan, Maria Teresa Ricci, Margherita Bignami, Lupe Sanchez-Mete, Alessandra Viel, Vittoria Stigliano, Elisa Giacomini, Liliana Varesco, Luigina Bonelli, Daniela Turchetti, Ricci, Maria Teresa, Miccoli, Sara, Turchetti, Daniela, Bondavalli, Davide, Viel, Alessandra, Quaia, Michele, Giacomini, Elisa, Gismondi, Viviana, Sanchez-Mete, Lupe, Stigliano, Vittoria, Martayan, Aline, Mazzei, Filomena, Bignami, Margherita, Bonelli, Luigina, and Varesco, Liliana
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Genotype ,Colonic Polyps ,Gene mutation ,Biology ,Bioinformatics ,Gastroenterology ,DNA Glycosylases ,Young Adult ,03 medical and health sciences ,Genetic ,MUTYH ,Internal medicine ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Genetic Association Studies ,Genetics (clinical) ,Aged ,Retrospective Studies ,Genetic testing ,Aged, 80 and over ,medicine.diagnostic_test ,Genetic heterogeneity ,MUTYH-Associated Polyposis ,Gene rearrangement ,Middle Aged ,medicine.disease ,Colon polyps ,Phenotype ,030104 developmental biology ,Italy ,Colorectal Polyp ,Mutation ,Female ,Colorectal Neoplasms ,Multiplex Polymerase Chain Reaction - Abstract
To determine prevalence, spectrum and genotype-phenotype correlations of MUTYH variants in Italian patients with suspected MAP (MUTYH-associated polyposis), a retrospective analysis was conducted to identify patients who had undergone MUTYH genetic testing from September 2002 to February 2014. Results of genetic testing and patient clinical characteristics were collected (gender, number of polyps, age at polyp diagnosis, presence of colorectal cancer (CRC) and/or other cancers, family data). The presence of large rearrangements of the MUTYH gene was evaluated by Multiplex Ligation-dependent Probe Amplification analysis. In all, 299 patients with colorectal neoplasia were evaluated: 61.2% were males, the median age at polyps or cancer diagnosis was 50 years (16-80 years), 65.2% had
- Published
- 2017
49. The PAMELA experiment: A decade of Cosmic Ray Physics in space
- Author
-
P. Spillantini, Matteo Martucci, Yu. T. Yurkin, Nicola Mori, M. Bongi, Riccardo Munini, S. Y. Krutkov, Per Carlson, G. Zampa, A. V. Karelin, Beatrice Panico, A. N. Kvashnin, R. Sparvoli, C. De Santis, C. De Donato, V. V. Malakhov, O. Adriani, P. Picozza, W. Menn, A. G. Mayorov, S. A. Voronov, M. Merge, G. A. Bazilevskaya, Sergey Koldobskiy, G. C. Barbarino, M. Simon, G. Osteria, G. I. Vasilyev, V. Di Felice, V. Bonvicini, S. Bottai, A. Bruno, Y. I. Stozhkov, N. Zampa, Maria Teresa Ricci, F. Cafagna, E. A. Bogomolov, Roberto Bellotti, E. Mocchiutti, V. V. Mikhailov, A. M. Galper, Mark Pearce, S. B. Ricciarini, P. Papini, E. Vannuccini, L. Marcelli, A. Vacchi, F. Palma, Mirko Boezio, Alexey Leonov, G. Castellini, Sergey Koldashov, D. Campana, Marco Casolino, Galper, A. M., Sparvoli, R., Adriani, O., Barbarino, G., Bazilevskaya, G. A., Bellotti, R., Boezio, M., Bogomolov, E. A., Bongi, M., Bonvicini, V., Bottai, S., Bruno, A., Cafagna, F., Campana, D., Carlson, P., Casolino, M., Castellini, G., De Donato, C., De Santis, C., Di Felice, V., Karelin, A. V., Koldashov, S. V., Koldobskiy, S. A., Krutkov, S. Y., Kvashnin, A. N., Leonov, A. A., Malakhov, V. V., Marcelli, L., Martucci, M., Mayorov, A. G., Menn, W., Merge, M., Mikhailov, V. V., Mocchiutti, E., Mori, N., Munini, R., Osteria, G., Palma, F., Panico, B., Papini, P., Pearce, M., Picozza, P., Ricci, M., Ricciarini, S. B., Simon, M., Spillantini, P., Stozhkov, Y. I., Vacchi, A., Vannuccini, E., Vasilyev, G. I., Voronov, S. A., Yurkin, Y. T., Zampa, G., and Zampa, N.
- Subjects
Physics ,Settore FIS/01 ,History ,COSMIC cancer database ,010504 meteorology & atmospheric sciences ,PAMELA detector ,Astronomy ,Cosmic ray ,Astrophysics ,Space (mathematics) ,Carbon ,Cosmology ,Earth (planet) ,High energy physics ,Positrons ,Radiation belts ,Solar energy Continuous data ,Elemental compositions ,Heliospheres ,Measurements of ,Quark matter ,Radiation environments ,Solar activity ,Solar modulation ,01 natural sciences ,Computer Science Applications ,Education ,law.invention ,On board ,Physics and Astronomy (all) ,law ,0103 physical sciences ,Satellite ,010306 general physics ,0105 earth and related environmental sciences - Abstract
The PAMELA detector was launched on June 15 th of 2006 on board the Russian Resurs-DK1 satellite and during ten years of continuous data-taking it has observed very interesting features in cosmic rays, especially in the fluxes of protons, helium and electrons. Moreover, PAMELA measurements of cosmic antiproton and positron fluxes and positron-to-all-electron ratio have set strong constraints to the nature of Dark Matter. Measurements of boron, carbon, lithium and beryllium (together with the isotopic fraction) have also shed new light on the elemental composition of the cosmic radiation. Search for signatures of more exotic processes (such as the ones involving Strange Quark Matter) has also been pursued. Furthermore, over the years the instrument has allowed a constant monitoring of the solar activity and a prolonged study of the solar modulation, improving the comprehension of the heliosphere mechanisms. PAMELA has also measured the radiation environment around the Earth, and detected for the first time the presence of an antiproton radiation belt surrounding our planet. In this highlight paper PAMELA main results will be reviewed.
- Published
- 2017
50. PAMELA'S MEASUREMENT OF GEOMAGNETIC CUTOFF VARIATIONS DURING SOLAR ENERGETIC PARTICLE EVENTS
- Author
-
Roberto Bellotti, N. De Simone, V. Bonvicini, S. Bottai, A. M. Galper, André Monaco, Mirko Boezio, Y. I. Stozhkov, M. Simon, G. A. Bazilevskaya, Ritabrata Sarkar, G. I. Vasilyev, R. Carbone, Sergey Koldobskiy, Y. T. Yurkin, A. V. Karelin, V. G. Zverev, G. C. Barbarino, L. Marcelli, F. Palma, R. Sparvoli, A. Vacchi, Maria Teresa Ricci, A. Bruno, G. Osteria, V. Di Felice, M. Bongi, G. Zampa, Beatrice Panico, Valentina Scotti, C. De Donato, V. Formato, N. Zampa, Per Carlson, S. A. Voronov, Riccardo Munini, F. Cafagna, E. A. Bogomolov, M. Merge, Matteo Martucci, A. Leonov, O. Adriani, W. Menn, V. V. Mikhailov, G. Castellini, C. De Santis, Nicola Mori, S. V. Koldashov, V. V. Malakhov, Mark Pearce, S. B. Ricciarini, P. Papini, E. Vannuccini, P. Spillantini, A. G. Mayorov, S. Y. Krutkov, D. Campana, Marco Casolino, P. Picozza, A. N. Kvashnin, and E. Mocchiutti
- Subjects
Physics ,Nuclear physics ,Earth's magnetic field ,Astrophysics::High Energy Astrophysical Phenomena ,Nuclear Theory ,Physics::Space Physics ,Measure (physics) ,Particle ,Cutoff ,Satellite ,Nuclear Experiment ,Physics::Atmospheric and Oceanic Physics - Abstract
Data from the PAMELA satellite experiment were used to measure the geomagnetic cutoff for high-energy ( 80 MeV) protons during the solar particle events on 2006 December 13 and 14. The variations o ...
- Published
- 2016
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.