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1. Abnormalities of Cortical Sources of Resting State Delta Electroencephalographic Rhythms Are Related to Epileptiform Activity in Patients With Amnesic Mild Cognitive Impairment Not Due to Alzheimer's Disease

Author

Claudio Babiloni, Giuseppe Noce, Carlo Di Bonaventura, Roberta Lizio, Maria Teresa Pascarelli, Federico Tucci, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Francesco Famà, Eleonora Palma, Pierangelo Cifelli, Moira Marizzoni, Fabrizio Stocchi, Giovanni B. Frisoni, and Claudio Del Percio

Subjects
amnesic mild cognitive impairment (aMCI), dementia, alzheheimer's disease, exact low-resolution brain electromagnetic source tomography (eLORETA), resting state electroencephalographic (rsEEG) rhythms, epileptiform electroencephalographic activity (EEA), Neurology. Diseases of the nervous system, RC346-429
Abstract

In the present exploratory and retrospective study, we hypothesized that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might be more abnormal in patients with epileptiform EEG activity (spike-sharp wave discharges, giant spikes) and amnesic mild cognitive impairment not due to Alzheimer's disease (noADMCI-EEA) than matched noADMCI patients without EEA (noADMCI-noEEA). Clinical, neuroimaging, neuropsychological, and rsEEG data in 32 noADMCI and 30 normal elderly (Nold) subjects were available in a national archive. Age, gender, and education were carefully matched among them. No subject had received a clinical diagnosis of epilepsy. Individual alpha frequency peak (IAF) was used to determine the delta, theta, and alpha frequency bands of rsEEG rhythms. Fixed beta and gamma bands were also considered. Regional rsEEG cortical sources were estimated by eLORETA freeware. Area under receiver operating characteristic (AUROC) curves indexed the accuracy of eLORETA solutions in the classification between noADMCI-EEA and noADMCI-noEEA individuals. As novel findings, EEA was observed in 41% of noADMCI patients. Furthermore, these noADMCI-EEA patients showed higher temporal delta source activities as compared to noADMCI-no EEA patients and Nold subjects. Those activities discriminated individuals of the two NoADMCI groups with an accuracy of about 70%. The significant percentage of noADMCI-EEA patients showing EEA and marked abnormalities in temporal rsEEG rhythms at delta frequencies suggest a substantial role of underlying neural hypersynchronization mechanisms in their brain dysfunctions.

Published
2020
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2. Late-Onset Epilepsy With Unknown Etiology: A Pilot Study on Neuropsychological Profile, Cerebrospinal Fluid Biomarkers, and Quantitative EEG Characteristics

Author

Elena Nardi Cesarini, Claudio Babiloni, Nicola Salvadori, Lucia Farotti, Claudio Del Percio, Maria Teresa Pascarelli, Giuseppe Noce, Roberta Lizio, Fulvio Da Re, Valeria Isella, Lucio Tremolizzo, Michele Romoli, Jacopo C. DiFrancesco, Lucilla Parnetti, and Cinzia Costa

Subjects
late onset epilepsy of unknown etiology, mild cognitive impairment, neuropsychology, CSF biomarkers, quantitative EEG, Neurology. Diseases of the nervous system, RC346-429
Abstract

Introduction: Despite the fact that epilepsy has been associated with cognitive decline, neuropsychological, neurobiological, and neurophysiological features in patients with late-onset epilepsy of unknown etiology (LOEU) are still unknown. This cross-sectional study aims to investigate the neuropsychological profile, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD), and resting-state quantitative electroencephalographic (qEEG) cortical rhythms in LOEU patients with mild cognitive impairment (LOEU-MCI) and with normal cognition (LOEU-CN), compared to non-epileptic MCI (NE-MCI) and cognitively normal (CN) controls.Methods: Consecutive patients in two clinical Units diagnosed with LOEU-CN (19), LOEU-MCI (27), and NE-MCI (21) were enrolled, and compared to age and sex-matched cognitively normal subjects CN (11). Patients underwent standardized comprehensive neuropsychological evaluation and CSF core AD biomarkers assessment (i.e., CSF Aβ42, phospho-tau and total tau, classified through A/T/(N) system). Recordings of resting-state eyes-closed electroencephalographic (EEG) rhythms were collected and cortical source estimation of delta (30 Hz) bands with exact Low Resolution Electromagnetic Tomography (eLORETA) was performed.Results: Most LOEU patients had an MCI status at seizure onset (59%). Patients with LOEU-MCI performed significantly worse on measures of global cognition, visuo-spatial abilities, and executive functions compared to NE-MCI patients (p < 0.05). Regarding MCI subtypes, multiple-domain MCI was 3-fold more frequent in LOEU-MCI than in NE-MCI patients (OR 3.14, 95%CI 0.93–10.58, p = 0.06). CSF Aβ42 levels were lower in the LOEU-MCI compared with the LOEU-CN group. Finally, parietal and occipital sources of alpha (8–12 Hz) rhythms were less active in the LOEU-MCI than in the NE-MCI and CN groups, while the opposite was true for frontal and temporal cortical delta sources.Discussion: MCI status was relatively frequent in LOEU patients, involved multiple cognitive domains, and might have been driven by amyloidosis according to CSF biomarkers. LOEU-MCI status was associated with abnormalities in cortical sources of EEG rhythms related to quiet vigilance. Future longitudinal studies should cross-validate our findings and test the predictive value of CSF and EEG variables.

Published
2020
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3. Corrigendum: Football Players Do Not Show 'Neural Efficiency' in Cortical Activity Related to Visuospatial Information Processing During Football Scenes: An EEG Mapping Study

Author

Claudio Del Percio, Mauro Franzetti, Adelaide Josy De Matti, Giuseppe Noce, Roberta Lizio, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Marco Rizzo, Antonio Ivano Triggiani, Fabrizio Stocchi, Cristina Limatola, and Claudio Babiloni

Subjects
football (soccer) players, electroencephalography, alpha rhythms, visuospatial information processing, parietal cortex, neural efficiency, Psychology, BF1-990
Published
2019
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4. Football Players Do Not Show 'Neural Efficiency' in Cortical Activity Related to Visuospatial Information Processing During Football Scenes: An EEG Mapping Study

Author

Claudio Del Percio, Mauro Franzetti, Adelaide Josy De Matti, Giuseppe Noce, Roberta Lizio, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Marco Rizzo, Antonio Ivano Triggiani, Fabrizio Stocchi, Cristina Limatola, and Claudio Babiloni

Subjects
football (soccer) players, electroencephalography, alpha rhythms, visuospatial information processing, parietal cortex, neural efficiency, Psychology, BF1-990
Abstract

This study tested the hypothesis of cortical neural efficiency (i.e., reduced brain activation in experts) in the visuospatial information processing related to football (soccer) scenes in football players. Electroencephalographic data were recorded from 56 scalp electrodes in 13 football players and eight matched non-players during the observation of 70 videos with football actions lasting 2.5 s each. During these videos, the central fixation target changed color from red to blue or vice versa. The videos were watched two times. One time, the subjects were asked to estimate the distance between players during each action (FOOTBALL condition, visuospatial). Another time, they had to estimate if the fixation target was colored for a longer time in red or blue color (CONTROL condition, non-visuospatial). The order of the two conditions was pseudo-randomized across the subjects. Cortical activity was estimated as the percent reduction in power of scalp alpha rhythms (about 8–12 Hz) during the videos compared with a pre-video baseline (event-related desynchronization, ERD). In the FOOTBALL condition, a prominent and bilateral parietal alpha ERD (i.e., cortical activation) was greater in the football players than non-players (p < 0.05) in contrast with the neural efficiency hypothesis. In the CONTROL condition, no significant alpha ERD difference was observed. No difference in behavioral response time and accuracy was found between the two groups in any condition. In conclusion, a prominent parietal cortical activity related to visuospatial processes during football scenes was greater in the football players over controls in contrast with the neural efficiency hypothesis.

Published
2019
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5. Stacked autoencoders as new models for an accurate Alzheimer’s disease classification support using resting-state EEG and MRI measurements

Author

Vania Karami, Andrea Romano, Filippo Carducci, Antonio Ivano Triggiani, Flavio Nobili, Maria Teresa Pascarelli, Franco Giubilei, Giovanni B. Frisoni, Alessandro Bozzao, Giuseppe Noce, Andrea Soricelli, Claudio Babiloni, Luca Patané, Raffaele Ferri, Fabrizio Stocchi, Francesco Amenta, Paolo Arena, Claudio Del Percio, and Roberta Lizio

Subjects
Neural Networks, Computer science, Alzheimer's Disease (AD), Low-resolution brain electromagnetic tomography (LORETA), Resting State Electroencephalography (rsEEG), Stacked Artificial Neural Networks (ANNs) with Autoencoders, 050105 experimental psychology, Structural magnetic resonance imaging, Computer, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Physiology (medical), Healthy control, Brain, Electroencephalography, Humans, Magnetic Resonance Imaging, Retrospective Studies, Neural Networks, Computer, 0501 psychology and cognitive sciences, Artificial neural network, business.industry, 05 social sciences, Disease classification, Pattern recognition, Sensory Systems, Neurology, High resolution eeg, Resting state eeg, National database, Neurology (clinical), Artificial intelligence, business, 030217 neurology & neurosurgery
Abstract

Objective This retrospective and exploratory study tested the accuracy of artificial neural networks (ANNs) at detecting Alzheimer’s disease patients with dementia (ADD) based on input variables extracted from resting-state electroencephalogram (rsEEG), structural magnetic resonance imaging (sMRI) or both. Methods For the classification exercise, the ANNs had two architectures that included stacked (autoencoding) hidden layers recreating input data in the output. The classification was based on LORETA source estimates from rsEEG activity recorded with 10–20 montage system (19 electrodes) and standard sMRI variables in 89 ADD and 45 healthy control participants taken from a national database. Results The ANN with stacked autoencoders and a deep leaning model representing both ADD and control participants showed classification accuracies in discriminating them of 80%, 85%, and 89% using rsEEG, sMRI, and rsEEG + sMRI features, respectively. The two ANNs with stacked autoencoders and a deep leaning model specialized for either ADD or control participants showed classification accuracies of 77%, 83%, and 86% using the same input features. Conclusions The two architectures of ANNs using stacked (autoencoding) hidden layers consistently reached moderate to high accuracy in the discrimination between ADD and healthy control participants as a function of the rsEEG and sMRI features employed. Significance The present results encourage future multi-centric, prospective and longitudinal cross-validation studies using high resolution EEG techniques and harmonized clinical procedures towards clinical applications of the present ANNs.

Published
2021

6. Different abnormalities of electroencephalographic (EEG) markers in quiet wakefulness are related to visual hallucinations in patients with Parkinson’s and Lewy body diseases

Author

Claudio Babiloni, Susanna Lopez, Maria Teresa Pascarelli, Roberta Lizio, Giuseppe Noce, Raffaele Ferri, Andrea Soricelli, Flavio Mariano Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Salvetti, Virginia Cipollini, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Dag Aarsland, Lucilla Parnetti, Lucia Farotti, Moira Marizzoni, Fabrizia D'Antonio, Carlo de Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek‐Savas, Antonio Ivano Triggiani, John‐Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Harald Hampel, Giovanni B Frisoni, Maria Francesca De Pandis, and Claudio Del Percio

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2020

7. Late‐onset epilepsy with unknown etiology: A pilot study on neuropsychological profile, cerebrospinal fluid biomarkers, and quantitative EEG characteristics

Author

Fulvio Da Re, Jacopo C. Di Francesco, Giuseppe Noce, Michele Romoli, Elena Nardi Cesarini, Claudio Babiloni, Lucio Tremolizzo, Valeria Isella, Maria Teresa Pascarelli, Lucilla Parnetti, Claudio Del Percio, Cinzia Costa, Lucia Farotti, Roberta Lizio, and Nicola Salvadori

Subjects
Epidemiology, business.industry, Health Policy, Neuropsychology, Quantitative eeg, Late onset epilepsy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Developmental Neuroscience, Neuroimaging, Etiology, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience
Published
2020

8. Different abnormalities of electroencephalographic (EEG) markers in quiet wakefulness are related to motor visual hallucinations in patients with Parkinson’s and Lewy body diseases

Author

Giovanni B. Frisoni, Moira Marizzoni, Ian G. McKeith, Dag Aarsland, Raffaele Ferri, Susanna Lopez, Görsev Yener, Lutfu Hanoglu, Gerhard Ransmayr, Maria Teresa Pascarelli, Laura Vacca, Lucia Farotti, Lucilla Parnetti, Carlo de Lena, Andrea Soricelli, Flavio Nobili, Marco Onofrj, Bahar Güntekin, John-Paul Taylor, Raffaella Franciotti, Laura Bonanni, Dario Arnaldi, Maria Francesca De Pandis, Peter Fuhr, Fabrizia D'Antonio, Ute Gschwandtner, Claudio Del Percio, Antonio Ivano Triggiani, Fabrizio Stocchi, Francesco Famà, Harald Hampel, Giuseppe Noce, Roberta Lizio, Derya Durusu Emek-Savaş, and Claudio Babiloni

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Lewy body, Epidemiology, business.industry, Health Policy, Electroencephalography, Audiology, medicine.disease, Visual Hallucination, Quiet wakefulness, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, In patient, Neurology (clinical), Geriatrics and Gerontology, business
Published
2020

9. Sensitivity and specificity of EEG biomarkers of AD at the preclinical stage

Author

Enrica Cavedo, Simone Lista, Bruno Dubois, Roberta Lizio, Fabrizio Stocchi, Andrea Vergallo, Michel J. Grothe, Giuseppe Spinelli, Francisco J. Fraga, Marie-Claude Potier, Claudio Del Percio, Nathalie George, Stefan J. Teipel, Harald Hampel, Marie-Odile Habert, Hovagim Bakardjian, Maria Teresa Pascarelli, Giuseppe Noce, Claudio Babiloni, Pablo Lemercier, Susanna Lopez, Raffaele Ferri, Gabriel González-Escamilla, and Patrizia A. Chiesa

Subjects
Oncology, medicine.medical_specialty, medicine.diagnostic_test, Epidemiology, business.industry, Health Policy, Electroencephalography, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Neurology (clinical), Sensitivity (control systems), Geriatrics and Gerontology, Preclinical stage, business
Published
2020

10. Ongoing Electroencephalographic Rhythms Related to Exploratory Movements in Transgenic TASTPM Mice

Author

Ditte Zerlang Christensen, Sophie Dix, Giuseppe Bertini, Fabrizio Stocchi, Maria Teresa Pascarelli, Bettina Laursen, Francesco Infarinato, Jill C. Richardson, Gianluigi Forloni, Jonathan Kelley, Andrea Soricelli, Paolo F. Fabene, Claudio Babiloni, Jan Torleif Pedersen, Giuseppe Noce, Valeria Colavito, Raffaele Ferri, Roberta Lizio, Susanna Lopez, Jesper F. Bastlund, Claudio Del Percio, Marina Bentivoglio, Francesco Noé, Wilhelmus Drinkenburg, and Angelisa Frasca

Subjects
0301 basic medicine, medicine.medical_specialty, Future studies, Transgene, Movement, Mice, Transgenic, Electroencephalography, Audiology, Active and passive state in wakefulness, TASTPM mice, wild type mice, 03 medical and health sciences, Amyloid beta-Protein Precursor, Mice, 0302 clinical medicine, Rhythm, Alzheimer Disease, PSEN1, Medicine, Animals, Cognitive Dysfunction, Wakefulness, Alzheimer’s disease, electroencephalography, medicine.diagnostic_test, business.industry, General Neuroscience, Brain, Reproducibility of Results, Cognition, General Medicine, Amyloidosis, Quiet wakefulness, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Eeg rhythms, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery
Abstract

Background: The European PharmaCog study (http://www.pharmacog.org) has reported a reduction in delta (1–6 Hz) electroencephalographic (EEG) power (density) during cage exploration (active condition) compared with quiet wakefulness (passive condition) in PDAPP mice (hAPP Indiana V717F mutation) modeling Alzheimer’s disease (AD) amyloidosis and cognitive deficits. Objective: Here, we tested the reproducibility of that evidence in TASTPM mice (double mutation in APP KM670/671NL and PSEN1 M146V), which develop brain amyloidosis and cognitive deficits over aging. The reliability of that evidence was examined in four research centers of the PharmaCog study. Methods: Ongoing EEG rhythms were recorded from a frontoparietal bipolar channel in 29 TASTPM and 58 matched “wild type” C57 mice (range of age: 12–24 months). Normalized EEG power was calculated. Frequency and amplitude of individual delta and theta frequency (IDF and ITF) peaks were considered during the passive and active conditions. Results: Compared with the “wild type” group, the TASTPM group showed a significantly lower reduction in IDF power during the active over the passive condition (p

Published
2020

11. Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study

Author

Raffaele Ferri, Harald Hampel, Hovagim Bakardjian, Bruno Dubois, Marie-Claude Potier, Stefan J. Teipel, Claudio Babiloni, Giuseppe Spinelli, Enrica Cavedo, Marie-Odile Habert, Simone Lista, Pablo Lemercier, Gabriel Gonzalez-Escamilla, Michel J. Grothe, Francisco J. Fraga, Roberta Lizio, Andrea Vergallo, Giuseppe Noce, Claudio Del Percio, Fabrizio Stocchi, Patrizia Andrea Chiesa, Nathalie George, Maria Teresa Pascarelli, Susanna Lopez, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Male, Aging, psychology [Alzheimer Disease], alpha rhythms, INSIGHT-preAD study, preclinical Alzheimer's disease (AD), preclinical Alzheimer's neuropathology, resting state EEG rhythms, subjective memory complaint (SMC), physiopathology [Brain], Cohort Studies, 0302 clinical medicine, Cognitive Reserve, Medicine, Prospective Studies, Cognitive reserve, Aged, 80 and over, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, 4. Education, General Neuroscience, Neurodegeneration, diagnosis [Alzheimer Disease], Brain, Cognition, Electroencephalography, Magnetic Resonance Imaging, Alpha Rhythm, [SCCO.PSYC]Cognitive science/Psychology, Educational Status, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Rest, Alpha (ethology), Neuropathology, Neuroprotection, physiopathology [Alzheimer Disease], 03 medical and health sciences, Rhythm, Alzheimer Disease, Memory, Humans, ddc:610, Aged, Resting state fMRI, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, medicine.disease, 030104 developmental biology, physiology [Rest], Positron-Emission Tomography, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience, 030217 neurology & neurosurgery, Developmental Biology
Abstract

International audience; Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyesclosed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly "neuro-protective"). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly "neuro-protective") and lower posterior alpha 2 power density (possibly "compensatory"). This effect may reflect cognitive reserve as no differences in brain graywhite matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness.

Published
2020

12. Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms

Author

Ian G. McKeith, Carla Buttinelli, Maria Francesca De Pandis, Raffaele Ferri, Francesco Famà, Laura Bonanni, Marco Rizzo, Bahar Güntekin, Peter Fuhr, Franco Giubilei, Virginia Cipollini, Moira Marizzoni, Dag Aarsland, Gerhard Ransmayr, Marco Onofri, Andrea Soricelli, Lucilla Parnetti, Maria Teresa Pascarelli, H. Hampel, Francesco Orzi, Marco Salvetti, Claudio Babiloni, Lutfu Hanoglu, Lucia Farotti, John-Paul Taylor, Giuseppe Noce, Görsev Yener, Susanna Lopez, Giovanni B. Frisoni, Raffaella Franciotti, Fabrizia D'Antonio, Antonio Ivano Triggiani, Laura Vacca, Ute Gschwandtner, Roberta Lizio, Fabrizio Stocchi, Derya Durusu Emek-Savaş, Dario Arnaldi, Carlo de Lena, Flavio Nobili, and Claudio Del Percio

Subjects
Male, Hallucinations, Visual Hallucinations, 0302 clinical medicine, Mild Cognitive Impairment (MCI), Prospective Studies, Mild cognitive impairment (MCI), Cortical Synchronization, Prospective cohort study, Exact low-resolution brain electromagnetic source tomography (eLORETA), Prodromal and overt dementia with Lewy bodies (DLB), Rapid eye movement sleep behavior disorders (RBD), Resting state electroencephalographic (EEG) rhythms, Visual hallucinations, Cerebral Cortex, Exact Low-Resolution Brain Electromagnetic Source Tomography (Eloreta), medicine.diagnostic_test, 05 social sciences, Electroencephalography, Parasomnia, Sensory Systems, Alpha Rhythm, Neurology, Female, Alzheimer's disease, Lewy Body Disease, medicine.medical_specialty, Aged, Cognitive Dysfunction, Default Mode Network, Humans, Prodromal Symptoms, behavioral disciplines and activities, 050105 experimental psychology, 03 medical and health sciences, Physiology (medical), Internal medicine, mental disorders, medicine, 0501 psychology and cognitive sciences, Mini–Mental State Examination, Resting state fMRI, Dementia with Lewy bodies, Surrogate endpoint, business.industry, Resting State Electroencephalographic (EEG) Rhythms, medicine.disease, nervous system diseases, Prodromal and Overt Dementia With Lewy Bodies (DLB), Rapid Eye Movement Sleep Behavior Disorders (RBD), Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms.Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources.Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB ``controls", the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005).Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients.Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies. Ministry of Health, Italy; H2020 Marie S. Curie ITN-ETN project; H2020-TWINN-2015 project

Published
2020

13. Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study

Author

Ian G. McKeith, H. Hampel, Dario Arnaldi, Francesco Orzi, Carla Buttinelli, Marco Salvetti, Laura Bonanni, Paola Stirpe, Susanna Lopez, Maria Francesca De Pandis, Ute Gschwandtner, Lutfu Hanoglu, Claudio Del Percio, Gerhard Ransmayr, Raffaella Franciotti, Bahar Güntekin, Francesco Famà, Laura Vacca, Peter Fuhr, Raffaele Ferri, Fabrizia D'Antonio, Dag Aarsland, Carlo de Lena, Flavio Nobili, John-Paul Taylor, Roberta Lizio, Moira Marizzoni, Franco Giubilei, Fabrizio Stocchi, Virginia Cipollini, Giuseppe Noce, Lucilla Parnetti, Görsev Yener, Lucia Farotti, Claudio Babiloni, Antonio Ivano Triggiani, Andrea Soricelli, Marco Onofrj, Derya Durusu Emek-Savaş, Giovanni B. Frisoni, Marco Rizzo, and Maria Teresa Pascarelli

Subjects
Male, 0301 basic medicine, Aging, Parkinson's disease, Hallucinations, Motor Disorders, Audiology, Electroencephalography, Resting-State Electroencephalographic (Rseeg) Rhythms, Visual Hallucinations, 0302 clinical medicine, Cortical Synchronization, media_common, Exact Low-Resolution Brain Electromagnetic Source Tomography (Eloreta), medicine.diagnostic_test, General Neuroscience, Visual hallucinations, Parkinson Disease, Cognition, Alpha Rhythm, Female, Wakefulness, Alzheimer's disease, Vigilance (psychology), medicine.medical_specialty, Parkinson's disease (PD), media_common.quotation_subject, Exact low-resolution brain electromagnetic source tomography (eLORETA), Mini-Mental State Evaluation (MMSE), Resting-state electroencephalographic (rsEEG) rhythms, Unified Parkinson Disease Rating Scale-III (UPDRS III), Neuropathology, 03 medical and health sciences, medicine, Humans, Cognitive Dysfunction, Aged, business.industry, medicine.disease, ddc:616.8, 030104 developmental biology, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Developmental Biology, Parkinson's Disease (PD)
Abstract

Compared with Alzheimer's disease (AD), Parkinson's disease (PD) shows peculiar clinical manifestations related to vigilance (i.e., executive cognitive deficits and visual hallucinations) that may be reflected in resting-state electroencephalographic rhythms. To test this hypothesis, clinical and resting-state electroencephalographic rhythms in age-, sex-, and education-matched PD patients (N = 136) and Alzheimer's disease patients (AD, N = 85), and healthy older participants (Nold, N = 65), were available from an international archive. Electroencephalographic sources were estimated by eLORETA software. The results are as follows: (1) compared to the Nold participants, the AD and PD patients showed higher widespread delta source activities (PD > AD) and lower posterior alpha source activities (AD > PD); (2) the PD patients with the most pronounced motor deficits exhibited very low alpha source activities in widespread cortical regions; (3) the PD patients with the strongest cognitive deficits showed higher alpha source activities in widespread cortical regions; and (4) compared to the PD patients without visual hallucinations, those with visual hallucinations were characterized by higher posterior alpha sources activities. These results suggest that in PD patients resting in quiet wakefulness, abnormalities in cortical neural synchronization at alpha frequencies are differently related to cognitive, motor, and visual hallucinations. Interestingly, parallel PD neuropathological processes may have opposite effects on cortical neural synchronization mechanisms generating cortical alpha rhythms in quiet wakefulness. (C) 2020 Elsevier Inc. All rights reserved.

Published
2020

14. Different Abnormalities of Cortical Neural Synchronization Mechanisms in Patients with Mild Cognitive Impairment due to Alzheimer’s and Chronic Kidney Diseases: An EEG Study

Author

Lucia Vernò, Maria Teresa Pascarelli, Raffaele Ferri, Deni Aldo Procaccini, Nicola Mastrofilippo, Antonia Losurdo, Franco Giubilei, Roberta Lizio, Valentina Catania, Giuseppe Dalfino, Claudio Babiloni, Francesco Famà, Francesco Orzi, Anna Maria Scisci, Marina de Tommaso, Claudio Del Percio, A Ivano Triggiani, Flavio Nobili, Anna Montemurno, Andrea Soricelli, Giovanni B. Frisoni, Loreto Gesualdo, Pietro Cirillo, Giuseppe Noce, and Carla Buttinelli

Subjects
Male, 0301 basic medicine, Disease, Neuropsychological Tests, Audiology, Electroencephalography, 0302 clinical medicine, Cortical Synchronization, media_common, medicine.diagnostic_test, exact low resolution brain electromagnetic source tomography (eLORETA), mild cognitive impairment due to Alzheimer's disease (ADMCI), mild cognitive impairment due to chronic kidney disease (CKDMCI), receiver operating characteristic (ROC) curve, resting state electroencephalographic (rsEEG) rhythms, neuroscience (all), clinical psychology, geriatrics and gerontology, psychiatry and mental health, Exact low resolution brain electromagnetic source tomography (eLORETA), General Neuroscience, Signal Processing, Computer-Assisted, General Medicine, Exact low resolution brain electromagnetic source tomography (eLORETA), mild cognitive impairment due to Alzheimer’s disease (ADMCI), mild cognitive impairment due to chronic kidney disease (CKDMCI), receiver operating characteristic (ROC) curve, resting state electroencephalographic (rsEEG) rhythms, Alpha Rhythm, Psychiatry and Mental health, Clinical Psychology, Female, Preliminary Data, Vigilance (psychology), medicine.medical_specialty, Rest, media_common.quotation_subject, Arousal, 03 medical and health sciences, Alzheimer Disease, medicine, Humans, Cognitive Dysfunction, Renal Insufficiency, Chronic, Wakefulness, Aged, Retrospective Studies, Receiver operating characteristic, Resting state fMRI, business.industry, medicine.disease, Institutional repository, 030104 developmental biology, Delta Rhythm, ROC Curve, ddc:618.97, mild cognitive impairment due to Alzheimer’s disease (ADMCI), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Kidney disease
Abstract

This study tested whether resting state alpha rhythms (8-13 Hz) may characterize mild cognitive impairment due to Alzheimer's disease (ADMCI) compared with MCI due to chronic kidney disease (CKDMCI). Clinical and resting state eyes-closed electroencephalographic (rsEEG) rhythms from 40 ADMCI, 29 CKDMCI, and 45 cognitively normal elderly (Nold) subjects were available in a national archive. Age, gender, and education were matched in the three groups, and Mini-Mental State Evaluation (MMSE) score was paired in the ADMCI and CKDMCI groups. Delta (

Published
2018

15. Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors

Author

Serena Notartomaso, Miriana Jlenia Quattromani, Claudio Babiloni, Francesco Scalabrì, Giuseppe Battaglia, Stefania Maccari, Sergio Fucile, Milena Cannella, Cristina Limatola, Claudio Del Percio, Ferdinando Nicoletti, Remy Verhaeghe, Giada Mascio, Giuseppina Chece, Domenico Bucci, Tiziana Imbriglio, Antonio Simeone, Tadeusz Wieloch, Katiuscia Martinello, Maria Teresa Pascarelli, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Università degli studi di Napoli Federico II, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Lund University [Lund], Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-University of Naples Federico II = Università degli studi di Napoli Federico II, Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Lille, CNRS, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.], Istituto di Ricovero e Cura a Carattere Scientifico [IRCCS], and Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]

Subjects
0301 basic medicine, Male, [SDV]Life Sciences [q-bio], Receptors, Metabotropic Glutamate, Biochemistry, cortical interneurons, 03 medical and health sciences, Mice, 0302 clinical medicine, Genetics, Animals, mGlu3 receptors, development, oscillations, perineuronal nets, RNA, Messenger, GABAergic Neurons, Receptor, Molecular Biology, Cerebral Cortex, Mice, Knockout, biology, GABAA receptor, Perineuronal net, Genes, Homeobox, Embryo, Mammalian, Immunohistochemistry, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, 030104 developmental biology, Gene Expression Regulation, nervous system, Metabotropic glutamate receptor, biology.protein, NMDA receptor, GABAergic, Female, Metabotropic glutamate receptor 3, Neuroscience, 030217 neurology & neurosurgery, Parvalbumin, Biomarkers, Biotechnology
Abstract

International audience; Polymorphic variants of the gene encoding for metabotropic glutamate receptor 3 (mGlu3) are linked to schizophrenia. Because abnormalities of cortical GABAergic interneurons lie at the core of the pathophysiology of schizophrenia, we examined whether mGlu3 receptors influence the developmental trajectory of cortical GABAergic transmission in the postnatal life. mGlu3‐/‐ mice showed robust changes in the expression of interneuron‐related genes in the prefrontal cortex (PFC), including large reductions in the expression of parvalbumin (PV) and the GluN1 subunit of NMDA receptors. The number of cortical cells enwrapped by perineuronal nets was increased in mGlu3‐/‐ mice, suggesting that mGlu3 receptors shape the temporal window of plasticity of PV+ interneurons. Electrophysiological measurements of GABAA receptor‐mediated responses revealed a more depolarized reversal potential of GABA currents in the somata of PFC pyramidal neurons in mGlu3‐/‐ mice at postnatal d 9 associated with a reduced expression of the K+/Cl‐ symporter. Finally, adult mGlu3‐/‐ mice showed lower power in electroencephalographic rhythms at 1‐45 Hz in quiet wakefulness as compared with their wild‐type counterparts. These findings suggest that mGlu3 receptors have a strong impact on the development of cortical GABAergic transmission and cortical neural synchronization mechanisms corroborating the concept that genetic variants of mGlu3 receptors may predispose to psychiatric disorders.— Imbriglio, T., Verhaeghe, R., Martinello, K., Pascarelli, M. T., Chece, G., Bucci, D., Notartomaso, S., Quattromani, M., Mascio, G., Scalabrì, F., Simeone, A., Maccari, S., Del Percio, C., Wieloch, T., Fucile, S., Babiloni, C., Battaglia, G., Limatola, C., Nicoletti, F., Cannella, M. Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors. FASEB J. 33, 14204‐14220 (2019). www.fasebj.org

Published
2019

16. Late-onset epilepsy with unknown etiology: Neuropsychological profile, cerebrospinal fluid biomarkers, and quantitative EEG characteristics

Author

Jacopo C. DiFrancesco, Fulvio Da Re, Michele Romoli, Maria Teresa Pascarelli, Giuseppe Noce, Lucilla Parnetti, Valeria Isella, Claudio Del Percio, Nicola Salvadori, Cinzia Costa, Claudio Babiloni, Lucia Farotti, Roberta Lizio, Elena Nardi Cesarini, and Lucio Tremolizzo

Subjects
Late onset epilepsy, Pathology, medicine.medical_specialty, Cerebrospinal fluid, Neurology, business.industry, Neuropsychology, Etiology, Medicine, Neurology (clinical), business, Quantitative eeg
Published
2021

17. Classification of healthy, Alzheimer’s disease, and Parkinson’s disease individuals with cortical generators of rsEEG rhythms

Author

R. Lizio, Raffaele Ferri, De Lena C, Giubilei R, Maria Teresa Pascarelli, Claudio Babiloni, Fabrizio Stocchi, Laura Bonanni, Del Percio C, Giuseppe Noce, Flavio Nobili, and Andrea Soricelli

Subjects
0301 basic medicine, medicine.medical_specialty, Parkinson's disease, Receiver operating characteristic, Resting state fMRI, business.industry, Alpha (ethology), Disease, Audiology, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Rhythm, medicine, Dementia, Beta (finance), business, 030217 neurology & neurosurgery
Abstract

In the present study, we verified the working hypothesis that cortical generators of resting state eyes-closed electroencephalographic (rsEEG) rhythms could classify with good performance (area under receiver operating characteristic, AUROC > 0.8) healthy elderly (Nold), Alzheimer’s disease (AD) and Parkinson’s disease (PD) individuals. rsEEG recordings were performed in 110 AD, 110 PD, and 75 Nold patients. Individual delta, theta, low-frequency alpha, and high-frequency bands were measured. Fixed low-frequency beta and high-frequency beta were also evaluated. eLORETA freeware measured cortical generators of rsEEG rhythms from posterior sources. Classification analysis was performed with the ROC curve. Cortical generators of posterior rsEEG rhythms at delta, theta, low-frequency alpha, high-frequency alpha, low-frequency beta, and high-frequency beta allowed a good performance (AUROC > 0.8) in the classification between healthy and neurodegenerative (i.e., AD and PD) individuals. Moreover, cortical generators of posterior rsEEG rhythms at low-frequency alpha permitted only a moderate performance (AUROC > 0.75) in the classification between AD and PD individuals. Future prospective cross-validation studies will have to test these candidate rsEEG markers for clinical applications and drug discovery.

Published
2019

18. Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults

Author

Jill C. Richardson, Pierre Payoux, Nicolas Chauveau, Claire Thalamas, Juergen Dukart, Maria Teresa Pascarelli, Raffaele Ferri, Philippe Derambure, Déborah Méligne, J.L. Bourriez, Claudio Del Percio, Roberta Lizio, Olivier Blin, Giuseppe Noce, Claudio Babiloni, Catherine Cassé-Perrot, David Bartrés-Faz, Laura Lanteaume, Dominique Deplanque, Régis Bordet, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), CHU Lille, Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), IRCCS SDN Napoli, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Imagerie cérébrale et handicaps neurologiques (ICHN), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC Lille), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), F. Hoffmann-La Roche [Basel], Istituto di Ricovero e Cura a Carattere Scientifico [Troina, Italy] (IRCCS), Oasi Maria Santissima Srl [Troina, Italy], GlaxoSmithKline [Stevenage, UK] (GSK), GlaxoSmithKline [Headquarters, London, UK] (GSK), Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], and Otten, Lisa

Subjects
wakefulness-promoting agents, Alzheimer’s disease (AD), Modafinil, Audiology, Resting state electroencephalographic (rsEEG) rhythms, 0302 clinical medicine, Alzheimer's disease (AD), exact low-resolution brain electromagnetic source tomography (eLORETA), resting state electroencephalographic (rsEEG) rhythms, sleep deprivation, adult, alpha rhythm, beta rhythm, brain waves, cerebral cortex, cross-over studies, delta rhythm, electroencephalography, functional laterality, camma rhythm, healthy volunteers, humans, male, rest, sample size, theta rhythm, wakefulness, Gamma Rhythm, media_common, medicine.diagnostic_test, 05 social sciences, Neuropsychological test, Sensory Systems, Sleep deprivation, Neurology, medicine.symptom, medicine.drug, Vigilance (psychology), medicine.medical_specialty, media_common.quotation_subject, 050105 experimental psychology, Arousal, 03 medical and health sciences, Physiology (medical), medicine, Exact low-resolution brain electromagnetic source tomography (eLORETA), 0501 psychology and cognitive sciences, Resting state fMRI, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, Alertness, Delta Rhythm, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Objective It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project ( www.pharmacog.org ): (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers. Methods rsEEG data were recorded in 36 healthy young adults before (Pre-sleep deprivation) and after (Post-sleep deprivation) one night of sleep deprivation. In the Post-sleep deprivation, these data were collected after a single dose of PLACEBO or MODAFINIL. rsEEG cortical sources were estimated by eLORETA freeware. Results In the PLACEBO condition, the sleep deprivation induced an increase and a decrease in posterior delta (2–4 Hz) and alpha (8–13 Hz) source activities, respectively. In the MODAFINIL condition, the vigilance enhancer partially recovered those source activities. Conclusions The present results suggest that posterior delta and alpha source activities may be both related to the regulation of human brain arousal and vigilance in quiet wakefulness. Significance Future research in healthy young adults may use this methodology to preselect new symptomatic drug candidates designed to normalize brain arousal and vigilance in seniors with dementia.

Published
2019

19. P3-110: PRECLINICAL ALZHEIMER'S DISEASE: WHICH EEG BIOMARKERS FOR PRECISION MEDICINE?

Author

Nathalie George, Marie-Odile Habert, Susanna Lopez, Maria Teresa Pascarelli, Stefan J. Teipel, Patrizia A. Chiesa, Michel J. Grothe, Hovagim Bakardjian, Giuseppe Noce, Roberta Lizio, Enrica Cavedo, Giuseppe Spinelli, Claudio Babiloni, Bruno Dubois, Gabriel González-Escamilla, Claudio Del Percio, Harald Hampel, Sarah Weschke, Marie-Claude Potier, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Oncology, medicine.medical_specialty, Epidemiology, Disease, Electroencephalography, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Internal medicine, medicine, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, business.industry, Health Policy, [SCCO.NEUR]Cognitive science/Neuroscience, Precision medicine, 3. Good health, Psychiatry and Mental health, [SCCO.PSYC]Cognitive science/Psychology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery
Abstract

International audience

Published
2019

20. O5‐03‐04: ABNORMALITIES OF ELECTROENCEPHALOGRAPHIC (EEG) MARKERS IN QUIET WAKEFULNESS ARE RELATED TO MOTOR DEFICITS, COGNITIVE SYMPTOMS, AND VISUAL HALLUCINATIONS IN PARKINSON'S DISEASE PATIENTS

Author

Raffaele Ferri, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Bahar Güntekin, Virginia Cipollini, Gerhard Ransmayr, Peter Fuhr, Lucia Farotti, Görsev Yener, Maria Francesca De Pandis, Lucilla Parnetti, Carlo de Lena, Laura Bonanni, Flavio Nobili, Dario Arnaldi, Maria Teresa Pascarelli, Paola Stirpe, Claudio Babiloni, Dag Aarsland, Andrea Soricelli, John-Paul Taylor, Harald Hampel, Claudio Del Percio, Laura Vacca, Raffaella Franciotti, Fabrizio Stocchi, Fabrizia D'Antonio, Ute Gschwandtner, Francesco Famà, Marco Rizzo, Susanna Lopez, Lutfu Hanoglu, Moira Marizzoni, Francesco Orzi, Marco Salvetti, Roberta Lizio, Giovanni B. Frisoni, Giuseppe Noce, Marco Onofrj, Franco Giubilei, Ian G. McKeith, and Carla Buttinelli

Subjects
medicine.medical_specialty, Cognitive Symptoms, Parkinson's disease, medicine.diagnostic_test, Epidemiology, business.industry, Health Policy, Electroencephalography, Audiology, medicine.disease, Visual Hallucination, Quiet wakefulness, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2019

21. Corrigendum to 'Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases' [Clin. Neurophysiol. 129 (2018) 766–782] (Clinical Neurophysiology (2018) 129(4) (766–782), (S1388245718300245), (10.1016/j.clinph.2018.01.009))

Author

Laura Vacca, Valentina Catania, Claudio Babiloni, Görsev Yener, Michela Pievani, Maria Teresa Pascarelli, Giovanni B. Frisoni, John-Paul Taylor, Heinrich Garn, Marco Onofrj, Ute Gschwandtner, Maria Francesca De Pandis, Erol Başar, Francesco Famà, Raffaele Ferri, Giuseppe Noce, Franco Giubilei, Gerhard Ransmayr, Andrea Soricelli, Lucia Fraioli, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Raffaella Franciotti, Fabrizia D'Antonio, Laura Bonanni, Carlo de Lena, Flavio Nobili, Carla Buttinelli, Susanna Lopez, Lutfu Hanoglu, Bahar Güntekin, Peter Fuhr, Dario Arnaldi, Paola Stirpe, Francesco Orzi, Claudio Del Percio, Fabrizio Stocchi, and Roberta Lizio

Subjects
Neurology, Resting state fMRI, Alpha rhythm, business.industry, Physiology (medical), Medicine, In patient, Neurology (clinical), Cognitive impairment, business, Neuroscience, Sensory Systems
Abstract

Orjinal Makale: Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases. 129(4), 766-782. https://doi.org/10.1016/j.clinph.2018.01.009

Published
2019

22. Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

Author

Maria Francesca De Pandis, Laura Bonanni, Moira Marizzoni, Maria Teresa Pascarelli, Susanna Lopez, Roberta Lizio, Giuseppe Noce, Fabrizio Stocchi, Raffaele Ferri, Marco Rizzo, Lucia Farotti, Carlo de Lena, Görsev Yener, Lutfu Hanoglu, Flavio Nobili, Claudio Babiloni, Bahar Güntekin, Gerhard Ransmayr, Raffaella Franciotti, H. Hampel, Francesco Orzi, Andrea Soricelli, Marco Salvetti, Peter Fuhr, Franco Giubilei, Fabrizia D'Antonio, Giovanni B. Frisoni, Ian G. McKeith, Derya Durusu Emek-Savaş, Dario Arnaldi, Paola Stirpe, Carla Buttinelli, Marco Onofrj, Francesco Famà, Lucilla Parnetti, Virginia Cipollini, Dag Aarsland, John-Paul Taylor, Claudio Del Percio, Antonio Ivano Triggiani, Laura Vacca, Ute Gschwandtner, Frisoni, Giovanni, Babiloni, Claudio, Del Percio, Claudio, Pascarelli, Maria Teresa, Lopez, Susanna Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Ple A Moro 5, I-00185 Rome, Italy, De Pandis, Maria Francesca Hosp San Raffaele Cassino, Cassino, FR, Italy, Rizzo, Marco, Ferri, Raffaele Oasi Res Inst IRCCS, Troina, Italy, Lizio, Roberta, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Nobili, Flavio, Arnaldi, Dario IRCCS Osped Policlin San Martino, Clin Neurol, Genoa, Italy, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dipartimento Neurosci Oftalmol Genet Riabilitaz &, Genoa, Italy, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco, Salvetti, Marco, Cipollini, Virginia Sapienza Univ Rome, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Salvetti, Marco IRCCS Ist Neurol Mediterraneo INM Neuromed Pozzil, Neuromed, Isernia, Italy, Franciotti, Raffaella, Onofrjt, Marco, Bonanni, Laura Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Bonanni, Laura Univ G dAnnunzio, CESI, Chieti, Italy, Stirpe, Paola, Stocchi, Fabrizio, Vacca, Laura IRCCS San Raffaele Pisana, Rome, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Kepler Univ Hosp, Fac Med, Dept Neurol 2, Med Campus 3, Linz, Austria, Aarsland, Dag Kings Coll Univ, Dept Old Age Psychiat, London, England, Parnetti, Lucilla, Farotti, Lucia Univ Perugia, Ctr Memory Disturbances, Sect Neurol, Lab Clin Neurochem, Perugia, Italy, Marizzoni, Moira, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, D'Antonio, Fabrizia, De Lena, Carlo Sapienza Univ Rome, Dept Human Neurosci, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Int Sch Med, Dept Biophys, Istanbul, Turkey, Hanoglu, Lutfu Istanbul Medipol Univ, Sch Med, Dept Neurol, Istanbul, Turkey, Yener, Gorsev Dokuz Eylul Univ, Dept Neurosci, Med Sch, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, Dept Neurol, Med Sch, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul, McKeith, Ian Newcastle Univ, Inst Neurosci, Newcastle, NSW, Australia, Hampel, Harald Brain & Spine Inst ICM, Inst Memory & Alzheimers Dis IM2A, Dept Neurol, Paris, France, Frisoni, Giovanni B. Univ Hosp, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, nobili, flavio -- 0000-0001-9811-0897, Ferri, Raffaele -- 0000-0001-6937-3065, Aarsland, Dag -- 0000-0001-6314-216X, triggiani, antonio ivano -- 0000-0003-3291-9452, and Babiloni, Claudio -- 0000-0002-5245-9839

Subjects
0301 basic medicine, Lewy Body Disease, Male, medicine.medical_specialty, Aging, Functional brain connectivity, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Mild cognitive impairment due to dementia with Lewy body (DLBMCI), Resting state EEG rhythms, Aged, Alzheimer Disease, Cerebral Cortex, Cognitive Dysfunction, Female, Humans, Rest, Alpha Rhythm, Alpha (ethology), Alzheimer's Disease (ADMCI), Functional brain connectivity, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Mild cognitive impairment due to dementia with Lewy body (DLBMCI), Resting state EEG rhythms, Neuroscience (all), Aging, Neurology (clinical), Developmental Biology, Geriatrics and Gerontology, Audiology, 03 medical and health sciences, 0302 clinical medicine, mental disorders, Mild Cognitive Impairment Due To, Medicine, Dementia, Mini–Mental State Examination, Neuroscience (all), Lewy body, Resting state fMRI, medicine.diagnostic_test, Receiver operating characteristic, business.industry, General Neuroscience, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Cerebral cortex, ddc:618.97, Neurology (clinical), Alzheimer's disease, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, functional brain connectivity, mild cognitive impairment due to Alzheimer's disease (ADMCI), mild cognitive impairment due to dementia with Lewy body (DLBMCI), resting state EEG rhythms, neuroscience (all), aging, neurology (clinical), developmental biology, geriatrics and gerontology, Developmental Biology
Abstract

WOS: 000465302200012 PubMed ID: 30797169 Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (

Published
2019

23. Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Author

Gerhard Ransmayr, Raffaella Franciotti, Ute Gschwandtner, Susanna Lopez, Lutfu Hanoglu, Fabrizia D'Antonio, Andrea Soricelli, Laura Vacca, Fabrizio Stocchi, Michela Pievani, Giovanni B. Frisoni, John-Paul Taylor, Giuseppe Noce, Marco Onofrj, Lucia Farotti, Valentina Catania, Maria Francesca De Pandis, Claudio Babiloni, Claudio Del Percio, Lucilla Parnetti, Laura Bonanni, Bahar Güntekin, Peter Fuhr, Francesco Famà, Carlo de Lena, Flavio Nobili, Raffaele Ferri, Dario Arnaldi, Lucia Fraioli, Paola Stirpe, Franco Giubilei, Derya Durusu Emek-Savaş, Ian G. McKeith, Carla Buttinelli, Roberta Lizio, Francesco Orzi, Görsev Yener, Maria Teresa Pascarelli, Antonio Ivano Triggiani, Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy, Stirpe, Paola, Fraioli, Lucia, Stocchi, Fabrizio, De Pandis, Maria Francesca IRCCS San Raffaele Pisana, Inst Res & Med Care, Rome, Italy, De Pandis, Maria Francesca Hosp San Raffaele Cassino, Cassino, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina Oasi Res Inst IRCCS, Troina, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco IRCCS Osped Policlin San Martino, San Martino Buon Albergo, Italy, Fama, Francesco Univ Genoa, Dipartimento Neurosci Oftalmol Genet Riabilitaz &, Genoa, Italy, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Bonanni, Laura, Franciotti, Raffaella, Onofrj, Marco Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Onofrj, Marco Univ G dAnnunzio, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Kepler Univ Hosp, Fac Med, Dept Neurol 2, Med Campus 3, Linz, Austria, Parnetti, Lucilla, Farotti, Lucia Univ Perugia, Sect Neurol, Lab Clin Neurochem, Ctr Memory Disturbances, Perugia, Italy, Pievani, Michela, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, D'Antonio, Fabrizia, De Lena, Carlo Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Dept Biophys, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Yener, Gorsev Dokuz Eylul Univ, Med Sch, Dept Neurosci, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, Med Sch, Dept Neurol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul, McKeith, Ian Newcastle Univ, Inst Neurosci, Newcastle, England, Vacca, Laura Casa Cura Privata Policlin CCPP Milano SpA, Milan, Italy, Frisoni, Giovanni B. Univ Hosp, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, Guntekin, Bahar -- 0000-0002-0860-0524, Ferri, Raffaele -- 0000-0001-6937-3065, triggiani, antonio ivano -- 0000-0003-3291-9452, McKeith, Ian -- 0000-0002-9250-0568, nobili, flavio -- 0000-0001-9811-0897, and Babiloni, Claudio -- 0000-0002-5245-9839

Subjects
0301 basic medicine, Male, functional brain connectivity, mild cognitive impairment due to Alzheimer's disease (ADMCI), mild cognitive impairment due to Parkinson's disease (PDMCI), resting state EEG rhythms, neuroscience, aging, neurology, developmental biology, geriatrics and gerontology, medicine.medical_specialty, Levodopa, Aging, Parkinson's disease, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Rest, Functional brain connectivity, Mild cognitive impairment due to Parkinson's disease (PDMCI), Resting state EEG rhythms, Neuroscience (all), Neurology (clinical), Developmental Biology, Geriatrics and Gerontology, Antiparkinson Agents, 03 medical and health sciences, 0302 clinical medicine, Aged, Cerebral Cortex, Cognitive Dysfunction, Electroencephalography, Female, Humans, Parkinson Disease, Internal medicine, Neuromodulation, medicine, Temporal cortex, Resting state fMRI, business.industry, General Neuroscience, Dopaminergic, medicine.disease, 3. Good health, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Carbidopa, ddc:618.97, Wakefulness, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

WOS: 000450412900002 PubMed ID: 30312790 We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (

Published
2019

24. Cortical sources of resting state electroencephalographic rhythms probe brain function in naïve HIV individuals

Author

Laura Gianserra, Raffaele Ferri, Lorenzo Ciullini, Paolo Onorati, Maria Teresa Pascarelli, Antonio Aceti, Gloria Crocetti, Giuseppe Noce, Valentina Catania, Claudio Babiloni, Claudio Del Percio, Paolo Roma, Ginevra Toma, Elisabetta Teti, Paolo Capotosto, Francesco Di Campli, Andrea Soricelli, Alfredo Pennica, Massimo Andreoni, Valentina Correr, Loredana Sarmati, Stefano Ferracuti, and Elisa Piccinni

Subjects
0301 basic medicine, Male, HIV Infections, Audiology, Electroencephalography, Neuropsychological Tests, 0302 clinical medicine, Cognition, Neuropsychological assessment, EEG, Cerebral Cortex, medicine.diagnostic_test, human immunodeficiency virus, Neuropsychology, low-resolution brain electromagnetic source tomography, Human immunodeficiency virus (HIV), LORETA, HIV, neuropsychological assessment, resting-state electroencephalography, sensory systems, neurology, physiology, Resting-state electroencephalography (EEG), Female, Low-resolution brain electromagnetic source tomography (LORETA), Sensory Systems, Neurology, Neurology (clinical), Physiology (medical), medicine.symptom, Adult, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, Rest, Asymptomatic, 03 medical and health sciences, Rhythm, Acquired immunodeficiency syndrome (AIDS), medicine, Humans, Resting state fMRI, business.industry, medicine.disease, 030104 developmental biology, business, 030217 neurology & neurosurgery
Abstract

Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS).EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest.Widespread sources of delta (4 Hz) and alpha (8-12 Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p 0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70-75%).Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level.This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits.

Published
2018

25. Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases

Author

Susanna Lopez, Lutfu Hanoglu, Raffaele Ferri, Raffaella Franciotti, Lucia Fraioli, Heinrich Garn, Francesco Famà, Dag Aarsland, Fabrizia D'Antonio, Bahar Güntekin, Andrea Soricelli, Peter Fuhr, Maria Francesca De Pandis, Görsev Yener, Marco Onofrj, Maria Teresa Pascarelli, Laura Bonanni, Carla Buttinelli, Francesco Orzi, Valentina Catania, Claudio Babiloni, Franco Giubilei, Erol Başar, Giuseppe Noce, Gerhard Ransmayr, John-Paul Taylor, Michela Pievani, Giovanni B. Frisoni, Claudio Del Percio, Antonio Ivano Triggiani, Carlo de Lena, Flavio Nobili, Laura Vacca, Derya Durusu Emek-Savaş, Ute Gschwandtner, Roberta Lizio, Dario Arnaldi, Paola Stirpe, Fabrizio Stocchi, Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy, Stocchi, Fabrizio, Vacca, Laura, Stirpe, Paola IRCCS San Raffaele Pisana, Inst Res & Med Care, Rome, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Dept Integrated Imaging, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina IRCCS Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dept Neuroscience DiNOGMI, Clin Neurol, Genoa, Italy, Fama, Francesco IRCCS AOU S Martino IST, Genoa, Italy, Aarsland, Dag Kings Coll Univ, Dept Old Age Psychiat, London, England, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Onofrj, Marco, Franciotti, Raffaella, Bonanni, Laura Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Bonanni, Laura Univ G dAnnunzio, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Med Fac, Kepler Univ Hosp, Dept Neurol 2, Med Campus 3, Linz, Austria, Garn, Heinrich AIT Austrian Inst Technol GmbH, Vienna, Austria, Fraioli, Lucia Hosp San Raffaele Cassino, Cassino, Italy, Pievani, Michela, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, Frisoni, Giovanni B. Univ Hosp Geneva, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp Geneva, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, D'Antonio, Fabrizia, De Lena, Carlo Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Dept Biophys, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Basar, Erol, Yener, Gorsev Dokuz Eylul Univ, IBG, Dept Neurol, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, IBG, Dept Neurosci, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul Newcastle Univ, Inst Neurosci, Newcastle, England, Guntekin, Bahar -- 0000-0002-0860-0524, Ferri, Raffaele -- 0000-0001-6937-3065, Pievani, Michela -- 0000-0002-1794-8987, triggiani, antonio ivano -- 0000-0003-3291-9452, Taylor, John-Paul -- 0000-0001-7958-6558, and Aarsland, Dag -- 0000-0001-6314-216X

Subjects
0301 basic medicine, Male, Audiology, 0302 clinical medicine, mild cognitive impairment due to dementia with Lewy bodies, media_common, resting state electroencephalographic rhythms, medicine.diagnostic_test, Exact low resolution brain electromagnetic source tomography (eLORETA), General Neuroscience, Brain, Electroencephalography, Signal Processing, Computer-Assisted, General Medicine, Psychiatry and Mental health, Clinical Psychology, mild cognitive impairment due to Alzheimer’s disease, receiver operating characteristic curve, Educational Status, Female, Alzheimer's disease, Vigilance (psychology), Lewy Body Disease, medicine.medical_specialty, media_common.quotation_subject, Rest, 03 medical and health sciences, Exact low resolution brain electromagnetic source tomography (eLORETA), mild cognitive impairment due to Alzheimer's disease, mild cognitive impairment due to dementia with Lewy bodies, receiver operating characteristic curve, resting state electroencephalographic rhythms, Alzheimer Disease, medicine, Humans, Cognitive Dysfunction, Aged, Retrospective Studies, Psychotropic Drugs, Mini–Mental State Examination, Resting state fMRI, Lewy body, Dementia with Lewy bodies, business.industry, medicine.disease, Mild Cognitive Impairment Due to Alzheimer's Disease, 030104 developmental biology, Delta Rhythm, ddc:618.97, Geriatrics and Gerontology, Occipital lobe, business, 030217 neurology & neurosurgery
Abstract

WOS: 000424245200019 PubMed ID: 29439335 The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC > 0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers. H2020 Marie S. Curie ITN-ETN project The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Bodies. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiag-itn-etn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.

Published
2018

26. Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases

Author

Raffaele Ferri, Susanna Lopez, Lutfu Hanoglu, Lucia Fraioli, Ute Gschwandtner, Francesco Orzi, Görsev Yener, Marco Onofrj, Gerhard Ransmayr, Laura Vacca, John-Paul Taylor, Raffaella Franciotti, Laura Bonanni, Bahar Güntekin, Andrea Soricelli, Michela Pievani, Giovanni B. Frisoni, Francesco Famà, Fabrizia D'Antonio, Peter Fuhr, Roberta Lizio, Giuseppe Noce, Maria Francesca De Pandis, Dario Arnaldi, Valentina Catania, Carlo de Lena, Antonio Ivano Triggiani, Flavio Nobili, Claudio Babiloni, Claudio Del Percio, Paola Stirpe, Erol Başar, Fabrizio Stocchi, Maria Teresa Pascarelli, Heinrich Garn, Derya Durusu Emek-Savaş, Franco Giubilei, Carla Buttinelli, Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Ple A Moro 5, I-00185 Rome, Italy, Stirpe, Paola, Stocchi, Fabrizio IRCCS San Raffaele Pisana Roma & Cassino, Inst Res & Med Care, Rome, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Dept Integrated Imaging, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina IRCCS Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dept Neurosci DiNOGMI, Clin Neurol, Genoa, Italy, Fama, Francesco IRCCS AOU S Martino IST, Genoa, Italy, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Bonanni, Laura, Franciotti, Raffaella, Onofrj, Marco Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Onofrj, Marco Univ G dAnnunzio, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Petersgraben 4, CH-4031 Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Kepler Univ Hosp, Fac Med, Dept Neurol 2, Med Campus 3,Krankenhausstr 9, A-4020 Linz, Austria, Garn, Heinrich AIT Austrian Inst Technol GmbH, Vienna, Austria, Fraioli, Lucia, De Pandis, Maria Francesca Hosp San Raffaele Cassino, Cassino, Italy, Pievanim, Michela, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, D'Antonio, Fabrizia, De Lena, Carlo Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Basar, Erol, Yener, Gorsev, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, Med Sch, Dept Neurol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul Newcastle Univ, Inst Neurosci, Newcastle, England, Vacca, Laura CCPP Milano SpA, Milan, Italy, Frisoni, Giovanni B. Univ Hosp Geneva, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp Geneva, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, Pievani, Michela -- 0000-0002-1794-8987, Ferri, Raffaele -- 0000-0001-6937-3065, Guntekin, Bahar -- 0000-0002-0860-0524, triggiani, antonio ivano -- 0000-0003-3291-9452, Taylor, John-Paul -- 0000-0001-7958-6558, nobili, flavio -- 0000-0001-9811-0897, Emek-Savas, Derya Durusu -- 0000-0001-7042-697X, and Stocchi, Fabrizio -- 0000-0002-5763-0033

Subjects
0301 basic medicine, Male, functional brain connectivity, mild cognitive impairment due to Alzheimer's disease (ADMCI), mild cognitive impairment due to Parkinson's disease (PDMCI), resting state EEG rhythms, sensory systems, neurology, physiology, Audiology, Neuropsychological Tests, 0302 clinical medicine, Mild Cognitive Impairment Due To, Beta Rhythm, Functional Brain Connectivity, Resting State EEG Rhythms, Cognitive impairment, Cerebral Cortex, Electroencephalography, Parkinson Disease, Sensory Systems, 3. Good health, Alpha Rhythm, Neurology, Functional brain connectivity, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Mild cognitive impairment due to Parkinson's disease (PDMCI), Resting state EEG rhythms, Sensory Systems, Neurology, Neurology (clinical), Physiology (medical), Female, Alzheimer's disease, Abnormality, medicine.medical_specialty, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Rest, Alpha (ethology), Alzheimer's Disease (ADMCI), Mild cognitive impairment due to Parkinson's disease (PDMCI), 03 medical and health sciences, Alpha rhythm, Alzheimer Disease, Physiology (medical), medicine, Humans, Cognitive Dysfunction, Resting state EEG rhythms, Aged, Retrospective Studies, Resting state fMRI, Receiver operating characteristic, business.industry, Functional brain connectivity, Parkinson's Disease (PDMCI), medicine.disease, Neurology (clinical), 030104 developmental biology, ddc:618.97, business, 030217 neurology & neurosurgery
Abstract

WOS: 000427485900009 PubMed ID: 29448151 Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70-0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. H Marie S. Curie ITN-ETN project The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. Dr. Erol Basar passed away due to health problems on October 28th (November 18th 1938-October 28th 2017) in Istanbul, during the editorial processing of this manuscript. Until the end of his life, he had been working to the development of EEG science and its application in Clinical Neurophysiology. He leaves to all us an invaluable scientific legacy in the Science of Brain Rhythms and Human Cognition. He also leaves a permanent reminder of scientific passion, academic soul, and social responsibility to all fortunate people who met and knew him during his intense life. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiag-ITNetn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.

Published
2018

27. P68-F Abnormalities of cortical neural synchronization mechanisms in patients with Alzheimer’s diseases dementia: An EEG study

Author

Claudio Babiloni, Maria Teresa Pascarelli, Marina Blūma, Giuseppe Noce, Vania Karami, Roberta Lizio, Francesco Amenta, and Claudio Del Percio

Subjects
medicine.medical_specialty, Receiver operating characteristic, Resting state fMRI, medicine.diagnostic_test, business.industry, 05 social sciences, Alpha (ethology), Audiology, Electroencephalography, medicine.disease, 050105 experimental psychology, Sensory Systems, Arousal, 03 medical and health sciences, 0302 clinical medicine, Rhythm, Neurology, Physiology (medical), medicine, Dementia, 0501 psychology and cognitive sciences, Neurology (clinical), Beta (finance), business, 030217 neurology & neurosurgery
Abstract

Background This retrospective study aimed to check whether the resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with Alzheimer’s disease dementia (ADD) at the group and the individual level. Methods Our dataset was an international archive of Clinical and rsEEG data of 42 ADD and 40 healthy elderly (Nold) subjects. The delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands were determined by Individual alpha frequency peak (IAF). Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic (ROC) curves. Results Compared to the Nold group, IAF showed slowing in the ADD group. Furthermore, The ADD group showed lower posterior alpha 2 source activities and higher occipital delta source activities. The ratio of occipital delta to alpha 2 allowed good classification accuracy (sensitivity: 88.1%, specificity: 85%, and accuracy: 86.6%) between the Nold and ADD individuals. Conclusion In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD patients compared with Nold subjects. An ongoing study is testing the enrichment of markers derived from structural magnetic resonance imaging (MRI) in the classification accuracy between Nold and ADD patients for potential clinical applications.

Published
2019

28. P4-176: ABNORMALITIES OF CORTICAL NEURAL SYNCHRONIZATION MECHANISMS IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER'S DISEASE AND EEG EPILEPTIFORM ACTIVITY

Author

Raffaele Ferri, Moira Marizzoni, Roberta Lizio, Pierangelo Cifelli, Fabrizio Stocchi, Maria Teresa Pascarelli, Giuseppe Noce, Francesco Famà, Claudio Del Percio, Cristina Limatola, Claudio Babiloni, Flavio Nobili, Carlo Di Bonaventura, Ali Mohamed Eldellaa, Eleonora Palma, Giovanni B. Frisoni, and Andrea Soricelli

Subjects
medicine.diagnostic_test, Epidemiology, business.industry, Health Policy, Disease, Electroencephalography, Neural synchronization, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive impairment, business, Neuroscience
Published
2019

29. Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

Author

Marco Onofrj, Maria Francesca De Pandis, Susanna Cordone, Claudio Del Percio, Claudio Babiloni, Georg Caravias, Francesco Orzi, Antonio Ivano Triggiani, Susanna Lopez, Fabrizio Stocchi, Lutfu Hanoglu, Bahar Güntekin, Peter Fuhr, Ute Gschwandtner, Michela Pievani, Görsev Yener, Giovanni B. Frisoni, Carlo de Lena, Giuseppe Noce, Raffaele Ferri, Flavio Nobili, Heinrich Garn, Fabiola Sorpresi, Maria Teresa Pascarelli, Gerhard Ransmayr, Dag Aarsland, Erol Başar, Derya Durusu Emek-Savaş, Carla Buttinelli, Dario Arnaldi, Paola Stirpe, Raffaella Franciotti, Andrea Soricelli, Fabrizia D'Antonio, Roberta Lizio, Laura Bonanni, and Franco Giubilei

Subjects
Male, 0301 basic medicine, Aging, Audiology, Electroencephalography, Resting state electroencephalographic (rsEEG) rhythms, ddc:616.89, 0302 clinical medicine, Alzheimer's disease dementia (ADD), Dementia with Lewy body (DLB), Exact low-resolution brain electromagnetic source tomography (eLORETA), Parkinson's disease dementia (PDD), Neuroscience (all), Developmental Biology, Geriatrics and Gerontology, Neurology (clinical), Cortical Synchronization, dementia with Lewy body (DLB), exact low-resolution brain electromagnetic source tomography (eLORETA), resting state electroencephalographic (rsEEG) rhythms, neuroscience, aging, developmental biology, geriatrics and gerontology, neurology, Cerebral Cortex, medicine.diagnostic_test, General Neuroscience, Female, Alzheimer's disease, Psychology, Lewy Body Disease, medicine.medical_specialty, Rest, behavioral disciplines and activities, 03 medical and health sciences, Alzheimer Disease, mental disorders, medicine, Humans, Dementia, Ocular Physiological Phenomena, Aged, Retrospective Studies, Mini–Mental State Examination, Lewy body, Resting state fMRI, medicine.disease, nervous system diseases, 030104 developmental biology, Occipital lobe, Neuroscience, 030217 neurology & neurosurgery
Abstract

WOS: 000405068100016 PubMed ID: 28454845 The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini-Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85-0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery. project "GRIDCORE" (Italian Ministry of Health, Finalized Research program) [RF-2010-2319113] The present study was developed based on the data of the informal European Consortium PDWAVES. The members and institutional affiliations of the Consortium are reported in the cover page of this manuscript. The activities for this study of Dr. Claudio Babiloni, Claudio Del Percio, and Roberta Lizio performed in the framework of the project "GRIDCORE" (Italian Ministry of Health, Finalized Research program, prot. RF-2010-2319113).

Published
2017

30. Abnormalities of Cortical Neural Synchronization Mechanisms in Subjects with Mild Cognitive Impairment due to Alzheimer's and Parkinson's Diseases: An EEG Study

Author

Michela Pievani, Giovanni B. Frisoni, Heinrich Garn, Claudio Del Percio, Gerhard Ransmayr, Francesco Famà, Bahar Güntekin, Fabrizio Stocchi, Peter Fuhr, Claudio Babiloni, Dag Aarsland, Görsev Yener, Raffaella Franciotti, Maria Francesca De Pandis, Fabrizia D'Antonio, Susanna Lopez, Georg Caravias, Francesco Orzi, Lutfu Hanoglu, Giuseppe Noce, Erol Başar, Raffaele Ferri, Laura Bonanni, Derya Durusu Emek-Savaş, Fabiola Sorpresi, Antonio Ivano Triggiani, Marco Onofrj, Ute Gschwandtner, Maria Teresa Pascarelli, Roberta Lizio, Dario Arnaldi, Andrea Soricelli, Paola Stirpe, Carlo de Lena, Flavio Nobili, Franco Giubilei, Susanna Cordone, and Carla Buttinelli

Subjects
Male, 0301 basic medicine, mild cognitive impairment due to Parkinson’s disease, Neuropsychological Tests, Electroencephalography, Audiology, Resting State Electroen-Cephalographic Rhythms, ddc:616.89, 0302 clinical medicine, media_common, resting state electroencephalographic rhythms, Aged, 80 and over, Cerebral Cortex, medicine.diagnostic_test, General Neuroscience, Parkinson Disease, General Medicine, Middle Aged, Clinical Psychology, Psychiatry and Mental Health, Female, Wakefulness, mild cognitive impairment due to Alzheimer’s disease, Alzheimer's disease, Exact low resolution brain electromagnetic source tomography, receiver operating characteristic curve, Psychology, Cortical Synchronization, Vigilance (psychology), medicine.medical_specialty, media_common.quotation_subject, mild cognitive impairment due to Alzheimer's disease, mild cognitive impairment due to Parkinson's disease, Geriatrics and Gerontology, 03 medical and health sciences, Neuroimaging, Alzheimer Disease, medicine, Humans, Cognitive Dysfunction, Aged, Retrospective Studies, Mini–Mental State Examination, Resting state fMRI, Spectrum Analysis, medicine.disease, Brain Waves, 030104 developmental biology, Mental Status Schedule, Neuroscience, 030217 neurology & neurosurgery
Abstract

WOS: 000404876400029 PubMed ID: 28621693 The aim of this retrospective and exploratory study was that the cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and Parkinson's disease (PDMCI) as compared to healthy subjects. Clinical and rsEEG data of 75 ADMCI, 75 PDMCI, and 75 cognitively normal elderly (Nold) subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) was matched between the ADMCI and PDMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROC) classified these sources across individuals. Results showed that compared to the Nold group, the posterior alpha2 and alpha3 source activities were more abnormal in the ADMCI than the PDMCI group, while the parietal delta source activities were more abnormal in the PDMCI than the ADMCI group. The parietal delta and alpha sources correlated with MMSE score and correctly classified the Nold and diseased individuals (area under the ROC=0.77-0.79). In conclusion, the PDMCI and ADMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test these rsEEG markers for clinical applications and drug discovery. Italian Ministry of Health [RF-2010-2319113] The present study was developed based on the data of the informal European Consortium PDWAVES. The members and institutional affiliations of the Consortium are reported in the cover page of this manuscript. The activities for this study of Dr. Claudio Babiloni, Claudio Del Percio, and Roberta Lizio were performed in the framework of the project "GRIDCORE" (Italian Ministry of Health, Finalized Research program, prot. RF-2010-2319113).

Published
2017

31. O-16 Resting-state functional cortical connectivity are abnormal in HIV patients

Author

Andrea Calcagno, Francesco Di Campli, Giovanni Di Perri, Massimo Andreoni, Massimo Galli, Claudio Babiloni, Benedetto Maurizio Celesia, Pasquale Pagliano, Giuseppe Noce, Annalisa Saracino, Stefano Ferracuti, Claudio Del Percio, Andrea Soricelli, Paolo Onorati, Maria Teresa Pascarelli, Massimo Di Pietro, Alfredo Pennica, Roberta Lizio, and Vincenzo Vullo

Subjects
medicine.medical_specialty, Receiver operating characteristic, Resting state fMRI, business.industry, Neuropsychology, Alpha (ethology), Cognition, Audiology, Sensory Systems, Quiet wakefulness, Neurology, Physiology (medical), Hiv patients, Medicine, Neurology (clinical), Cognitive decline, business
Abstract

Background Previous evidence showed abnormal sources of resting-state delta ( Material and methods The rsEEG, clinical, and neuropsychological data were collected in 128 naive HIV subjects with normal cognition or mild cognitive deficits and 60 control (Healthy) subjects. The eLORETA freeware estimated source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Healthy and HIV individuals. Results Posterior interhemispheric and diffuse intrahemispheric LLC solutions in alpha sources were abnormally lower in both HIV subgroups with and without mild cognitive deficits subjects, compared with the Healthy group. Noteworthy, HIV subgroup with cognitive deficits showed greater abnormalities than HIV subgroup with normal cognition. Furthermore, AUROC curves of those alpha LLC solutions exhibited moderate accuracies (>0.7) in the discrimination of control vs. HIV individuals with mild cognitive deficits. Conclusions Naive HIV subjects in quiet wakefulness were characterized by abnormalities in widespread alpha source connectivity, which were greater when related to mild cognitive deficits. Widespread alpha source connectivity may reflect HIV effects on brain and cognitive functions before drug regimens. Future studies may test utility of the present approach to select HIV subjects prone to cognitive decline over time and to track brain functions after neuroprotective anti-HIV drug regimens.

Published
2019

32. P67-F rsEEG markers in subjects with MCI due to Alzheimer’s disease (ADMCI) and interictal epileptiform discharge

Author

Flavio Nobili, Maria Teresa Pascarelli, Andrea Soricelli, Francesco Famà, Cristina Limatola, Giuseppe Noce, Claudio Babiloni, Carlo Di Bonaventura, Giovanni B. Frisoni, Pierangelo Cifelli, Dott. Ali Eldellaa, Moira Marizzoni, Eleonora Palma, Claudio Del Percio, Fabrizio Stocchi, Raffaele Ferri, and Roberta Lizio

Subjects
medicine.medical_specialty, Resting state fMRI, Receiver operating characteristic, medicine.diagnostic_test, business.industry, Neuropsychology, Alpha (ethology), Audiology, Electroencephalography, medicine.disease, Sensory Systems, Arousal, Neurology, Physiology (medical), Medicine, Dementia, Ictal, Neurology (clinical), business
Abstract

Background It is well-known that compared to normal elderly (Nold) subjects, patients with dementia due to Alzheimer’s disease (ADD) manifest ten times convulsive seizures. The present study tested the different features of the resting state eyes-closed electroencephalographic (rsEEG) rhythms in a group of patients with mild cognitive impairment due to AD and interictal epileptiform discharge (ADMCI IED+), compared to groups of ADMCI patients without interictal epileptiform discharge (ADMCI IED−), ADD patients, and Nold subjects. Methods Clinical, neuropsychological, and rsEEG data, in 30 Nold, 31 ADMCI IED−, 11 ADMCI IED+, and 30 ADD subjects were available in an international archive. Individual alpha frequency peak was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were considered. eLORETA estimated the rsEEG cortical sources in EEG segments free from artifacts and IED. The analysis of the area under the receiver operating characteristic (AUROC) curve computed the classification rate. Results Compared to the Nold group, the ADMCI IED−, ADMCI IED+ and ADD groups presented higher widespread delta source activities and lower posterior alpha source activities. As novel EEG results, compared to the ADMCI IED- group, the ADMCI IED+ unveiled higher frontal and temporal delta source activities. Furthermore, temporal delta source activity allowed a good classification (AUROC > 0.85) between the ADMCI IED− and ADMCI IED+ individuals. Conclusions In quiet wakefulness, the abnormalities in cortical neural synchronization underpinning brain arousal at delta frequencies are higher in the ADMCI IED+ than the ADMCI IED− subjects.

Published
2019

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