1. Brain age in mood and psychotic disorders: a systematic review and meta‐analysis
- Author
-
Maria T. Romano, Sidney H. Kennedy, Taiane de Azevedo Cardoso, Stefanie Hassel, Benicio N. Frey, Stephen C. Strother, and Pedro Ballester
- Subjects
medicine.medical_specialty ,Psychosis ,business.industry ,medicine.disease ,Psychiatry and Mental health ,Mood ,Neuroimaging ,Schizophrenia ,Meta-analysis ,medicine ,Major depressive disorder ,Bipolar disorder ,Psychiatry ,business ,Brain aging - Abstract
OBJECTIVE To evaluate whether accelerated brain aging occurs in individuals with mood or psychotic disorders. METHODS A systematic review following PRISMA guidelines was conducted. A meta-analysis was then performed to assess neuroimaging-derived brain age gap in three independent groups: (1) schizophrenia and first-episode psychosis, (2) major depressive disorder, and (3) bipolar disorder. RESULTS A total of 18 papers were included. The random-effects model meta-analysis showed a significantly increased neuroimaging-derived brain age gap relative to age-matched controls for the three major psychiatric disorders, with schizophrenia (3.08; 95%CI [2.32; 3.85]; p
- Published
- 2021