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Background Chronic spontaneous urticaria (CSU) may be associated with autoimmune thyroid diseases, and the Autologous Serum Skin Test (ASST) is an autoreactivity marker. The thyrotropin (TSH) and TSH receptor (TSHR) could play a role in the pathogenesis of CSU. The aim of this study was to evaluate ASST positivity and TSHR gene expression in healthy skin and ASST wheals in euthyroid women with CSU, with (14 patients) and without (15 patients) Hashimoto's thyroiditis (HT). Methods ASST was performed and TSHR gene expression studied in wheals induced by ASST and in healthy skin. Results ASST presented greater positivity (86% × 40%) and larger diameter (10.8 × 9.6 mm) in the HT group (P

Made available in DSpace on 2019-10-04T12:38:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-03-01. Added 1 bitstream(s) on 2019-10-09T18:34:12Z : No. of bitstreams: 1 S0365-05962019000700056.pdf: 486399 bytes, checksum: a2e0a3f4581e4f634c104b420135972a (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) BACKGROUND: Urticarias are frequent diseases, with 15% to 20% of the population presenting at least one acute episode in their lifetime. Urticaria are classified in acute ( 6 weeks). They may be induced or spontaneous. OBJECTIVES: To verify the diagnostic and therapeutic recommendations in chronic spontaneous urticaria (CSU), according to the experience of Brazilian experts, regarding the available guidelines (international and US). Methods: A questionnaire was sent to Brazilian experts, with questions concerning diagnostic and therapeutic recommendations for CSU in adults. RESULTS: Sixteen Brazilian experts answered the questionnaire related to diagnosis and therapy of CSU in adults and data were analyzed. Final text was written, considering the available guidelines (International and US), adapted to the medical practices in Brazil. Diagnostic work up in CSU is rarely necessary. Biopsy of skin lesion and histopathology may be indicated to rule out other diseases, such as, urticarial vasculitis. Other laboratory tests, such as complete blood count, CRP, ESR and thyroid screening. Treatment of CSU includes second-generation anti-histamines (sgAH) at licensed doses, sgAH two, three to fourfold doses (non-licensed) and omalizumab. Other drugs, such as, cyclosporine, immunomodulatory drugs and immunosuppressants may be indicated (non-licensed and with limited scientific evidence). CONCLUSIONS: Most of the Brazilian experts in this study partially agreed with the diagnostic and therapeutic recommendations of the International and US guidelines. They agreed with the use of sgAH at licensed doses. Increase in the dose to fourfold of sgAH may be suggested with restrictions, due to its non-licensed dose. Sedating anti-histamines, as suggested by the US guideline, are indicated by some of the Brazilian experts, due to its availability. Adaptations are mandatory in the treatment of CSU, due to scarce or lack of other therapeutic resources in the public health system in Brazil, such as omalizumab or cyclosporine. Univ Sao Paulo, Dermatol, Fac Med, Sao Paulo, SP, Brazil Fac Med ABC, Postgrad Program, Sao Paulo, SP, Brazil Univ Sao Paulo, Dept Dermatol, Fac Med, Sao Paulo, SP, Brazil Univ Fed Pernambuco, Recife, PE, Brazil Univ Nove Julho, Dermatol, Sao Paulo, SP, Brazil Univ Fed Minas Gerais, Dermatol Serv, Hosp Clin, Belo Horizonte, MG, Brazil Univ Fed Minas Gerais, Dermatol, Fac Med, Belo Horizonte, MG, Brazil Univ Fed Pernambuco, Dept Dermatol, Ctr Ciencias Med, Fac Med, Recife, PE, Brazil Fac Evangel Curitiba, Dermatol Serv, Curitiba, Parana, Brazil Univ Sao Paulo, Div Dermatol, Hosp Clin, Fac Meclicina, Sao Paulo, SP, Brazil Univ Estadual Paulista, Dept Dermatol & Radiotherapy, Botucatu, SP, Brazil Hosp Padre Bento Guarulhos, Training & Improvement Management, Sao Paulo, SP, Brazil Hosp Serv Publ Estadual Sao Paulo, Dermatol Serv, Sao Paulo, SP, Brazil Univ Fed Sao Paulo, Urticaria Outpatient Clin, Dept Dermatol, Sao Paulo, SP, Brazil Univ Fed Rio Grande do Sul, Dermatol Serv, Hosp Clin Porto Alegre, Fac Med, Porto Alegre, RS, Brazil Ambulatorio Dermatol Sanitaria, Porto Alegre, RS, Brazil Santa Casa Porto Alegre, Dermatol Serv, Porto Alegre, RS, Brazil Santa Casa Misericordia Sao Paulo, Dermatol Clin, Sao Paulo, SP, Brazil Santa Casa Misericardia Sao Paulo, Dermatol, Fac Ciencias Med, Sao Paulo, SP, Brazil Fac Med ABC, Sao Paulo, SP, Brazil Univ Estadual Paulista, Dept Dermatol & Radiotherapy, Botucatu, SP, Brazil CAPES: 001

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:05:58Z No. of bitstreams: 1 S1516-31802012000500005.pdf: 174768 bytes, checksum: 2e10dfd0b3bafd1703902bcc592727a9 (MD5) Made available in DSpace on 2013-08-22T19:05:58Z (GMT). No. of bitstreams: 1 S1516-31802012000500005.pdf: 174768 bytes, checksum: 2e10dfd0b3bafd1703902bcc592727a9 (MD5) Previous issue date: 2012-01-01 Made available in DSpace on 2013-09-30T18:18:15Z (GMT). No. of bitstreams: 2 S1516-31802012000500005.pdf: 174768 bytes, checksum: 2e10dfd0b3bafd1703902bcc592727a9 (MD5) S1516-31802012000500005.pdf.txt: 23259 bytes, checksum: eff1a493d39add3442dc231d9edaad5a (MD5) Previous issue date: 2012-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:33:52Z No. of bitstreams: 2 S1516-31802012000500005.pdf: 174768 bytes, checksum: 2e10dfd0b3bafd1703902bcc592727a9 (MD5) S1516-31802012000500005.pdf.txt: 23259 bytes, checksum: eff1a493d39add3442dc231d9edaad5a (MD5) Made available in DSpace on 2014-05-20T13:33:52Z (GMT). No. of bitstreams: 2 S1516-31802012000500005.pdf: 174768 bytes, checksum: 2e10dfd0b3bafd1703902bcc592727a9 (MD5) S1516-31802012000500005.pdf.txt: 23259 bytes, checksum: eff1a493d39add3442dc231d9edaad5a (MD5) Previous issue date: 2012-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) CONTEXTO E OBJETIVO: A associação de urticária crônica idiopática (UCI) com doença autoimune da tireoide (DAT) é relatada. Porém, não foram encontrados relatos se a DAT eleva o risco de angioedema, uma apresentação clínica mais grave da UCI. Assim, o objetivo do presente estudo foi avaliar se o risco de angioedema está aumentado em pacientes com UCI e DAT. TIPO DE ESTUDO E LOCAL: Estudo caso-controle, incluindo 115 pacientes com UCI em uma instituição pública terciária. MÉTODOS: Os pacientes foram avaliados quanto à ocorrência de angioedema e à presença de DAT, hiper ou hipotireoidismo. RESULTADOS: Angioedema ocorreu em 70 pacientes (60,9%). Foram observados 22 (19,1%) casos de DAT, 19 (16,5%) de hipotireoidismo e 9 (7,8%) de hipertireoidismo. Os pacientes com DAT apresentaram risco 16,2 vezes maior de angioedema do que os sem a alteração tireoidiana (intervalo de confiança, IC = 2.07-126.86). O odds ratio, para hipotireoidismo, foi de 4,6 (IC = 1.00-21.54) e para hipertireoidismo foi de 3,3 (IC = 0.38-28.36). CONCLUSÕES: Pacientes com UCI e DAT apresentaram maior risco de angioedema, reforçando a ideia de existência de relação entre o quadro alérgico e autoimunidade tireoidiana. Este achado poderia implicar em um direcionamento terapêutico específico para tais pacientes. CONTEXT and OBJECTIVE: An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD. DESIGN and SETTING: Case-control study including 115 patients with CIU at a tertiary public institution. METHODS: The patients were evaluated with regard to occurrence of angioedema and presence of ATD, hypothyroidism or hyperthyroidism. RESULTS: Angioedema was detected in 70 patients (60.9%). There were 22 cases (19.1%) of ATD, 19 (16.5%) of hypothyroidism and nine (7.8%) of hyperthyroidism. The risk among patients with ATD was 16.2 times greater than among those without this thyroid abnormality (confidence interval, CI = 2.07-126.86). The odds ratio for hypothyroidism was 4.6 (CI = 1.00-21.54) and, for hyperthyroidism, 3.3 (CI = 0.38-28.36). CONCLUSIONS: Patients with CIU and ATD presented greater risk of angioedema, which reinforces the idea that a relationship exists between this allergic condition and thyroid autoimmunity. This finding could imply that such patients require specifically directed therapy. Universidade Estadual Paulista Botucatu Medical School Department of Dermatology and Radiotherapy Universidade Estadual Paulista Botucatu Medical School Department of Internal Medicine Universidade Estadual Paulista Botucatu Medical School Internal Medicine Department Universidade Estadual Paulista Botucatu Medical School Department of Dermatology and Radiotherapy Universidade Estadual Paulista Botucatu Medical School Department of Internal Medicine Universidade Estadual Paulista Botucatu Medical School Internal Medicine Department FAPESP: 07/54859-1 FAPESP: 07/54860-0

OBJETIVO: Avaliar o impacto da urticária crônica na qualidade de vida dos pacientes de ambulatório universitário a partir do questionário DLQI (Dermatology Life Quality Index). MÉTODOS: Inquérito sobre o impacto na qualidade de vida infligido pela urticária crônica a partir do questionário DLQI validado para a língua portuguesa. Pacientes foram entrevistados durante suas consultas em ambulatório especializado, entre maio de 2009 e maio de 2010, em serviço público brasileiro (Botucatu-SP). Os escores do DLQI foram analisados segundo subgrupos: idade, gênero, escolaridade, tempo de doença e presença de angioedema. RESULTADOS: Foram entrevistados 100 pacientes com urticária crônica. Predominou o gênero feminino (86%), a idade média foi de 41,8 anos, duração média da doença foi de seis anos e angioedema ocorreu em 82% dos pacientes. O escore médio do DLQI foi de 13,5, caracterizando grave impacto à qualidade de vida, superior a hanseníase, psoríase, eczema atópico e carcinoma basocelular. Presença de angioedema se associou a maiores escores: 14,5 x 9,9 (p < 0,01). Pacientes do gênero feminino referiram maior impacto quanto ao vestuário, já o gênero masculino referiu quanto ao tratamento, trabalho e estudo (p < 0,05). CONCLUSÃO: Urticária crônica inflige grave comprometimento da qualidade de vida nos pacientes avaliados em serviço universitário brasileiro, especialmente nos portadores de angioedema.OBJECTIVE: To evaluate the impact of chronic urticaria on quality of life of outpatients through the university questionnaire Dermatology Life Quality Index (DLQI). METHODS: Survey of the impact on quality of life caused by chronic urticaria, using the DLQI questionnaire validated for the Portuguese language. Patients were interviewed during visits to a specialized outpatient clinic between May 2009 and May 2010 at a Brazilian public service (Botucatu-SP). DLQI scores were analyzed according to the following subgroups: age, gender, education, disease duration, and presence of angioedema. RESULTS: We interviewed 100 patients with chronic urticaria. There was a female predominance (86%), mean age 41.8 years, mean disease duration of 6 years, and angioedema occurrence in 82% of patients. The mean DLQI score was 13.5, characterized by serious impact on quality of life, higher than Hansen's disease, psoriasis, atopic eczema, and basal cell carcinoma. The presence of angioedema was associated with higher scores: 14.5 x 9.9 (p < 0.01). Female patients reported greater impact on clothing, while male patients reported treatment interference with work and study (p < 0.05). CONCLUSION: Chronic urticaria seriously compromises the quality of life of patients evaluated at a university service in Brazil, particularly of patients with angioedema.

Made available in DSpace on 2022-04-29T01:26:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-01-01 Objective: To evaluate the impact of chronic urticaria on quality of life of outpatients through the university questionnaire Dermatology Life Quality Index (DLQI). Methods: Survey of the impact on quality of life caused by chronic urticaria, using the DLQI questionnaire validated for the Portuguese language. Patients were interviewed during visits to a specialized outpatient clinic between May 2009 and May 2010 at a Brazilian public service (Botucatu-SP). DLQI scores were analyzed according to the following subgroups: age, gender, education, disease duration, and presence of angioedema. Results: We interviewed 100 patients with chronic urticaria. There was a female predominance (86%), mean age 41.8 years, mean disease duration of 6 years, and angioedema occurrence in 82% of patients. The mean DLQI score was 13.5, characterized by serious impact on quality of life, higher than Hansen's disease, psoriasis, atopic eczema, and basal cell carcinoma. The presence of angioedema was associated with higher scores: 14.5 x 9.9 (p

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:29:04Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:37:29Z : No. of bitstreams: 1 2-s2.0-84879564844.pdf: 310476 bytes, checksum: d3a199b27ffe2440fe5bfbb0db39435a (MD5) Made available in DSpace on 2014-05-27T11:29:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-05-01 Histoplasmosis is a systemic mycosis endemic in extensive areas of the Americas. The authors report on an urban adult male patient with uncommon oral-cutaneous lesions proven to be histoplasmosis. Additional investigation revealed unnoticed HIV infection with CD4+ cell count of 7/mm3. The treatment was performed with amphotericin B, a 2065 mg total dose followed by itraconazole 200mg/daily plus antiretroviral therapy with apparent cure. Histoplasmosis is an AIDS-defining opportunistic disease process; therefore, its clinical diagnosis must drive full laboratory investigation looking for unnoted HIV-infection. © 2013 by Anais Brasileiros de Dermatologia. Department of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University (Unesp), Sao Paulo (SP) Department of Pathology Botucatu Medical School São Paulo State University (Unesp), Sao Paulo (SP) Department of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University (Unesp), Sao Paulo (SP) Department of Pathology Botucatu Medical School São Paulo State University (Unesp), Sao Paulo (SP)

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:02:01Z No. of bitstreams: 1 S0104-42302011000500018.pdf: 208601 bytes, checksum: 561c73c0c4580446d10fc630a7b24abb (MD5) Made available in DSpace on 2013-08-22T19:02:01Z (GMT). No. of bitstreams: 1 S0104-42302011000500018.pdf: 208601 bytes, checksum: 561c73c0c4580446d10fc630a7b24abb (MD5) Previous issue date: 2011-10-01 Made available in DSpace on 2013-09-30T18:18:43Z (GMT). No. of bitstreams: 2 S0104-42302011000500018.pdf: 208601 bytes, checksum: 561c73c0c4580446d10fc630a7b24abb (MD5) S0104-42302011000500018.pdf.txt: 20354 bytes, checksum: af7c5799d0257de6eb35cd402d69626f (MD5) Previous issue date: 2011-10-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:34:12Z No. of bitstreams: 2 S0104-42302011000500018.pdf: 208601 bytes, checksum: 561c73c0c4580446d10fc630a7b24abb (MD5) S0104-42302011000500018.pdf.txt: 20354 bytes, checksum: af7c5799d0257de6eb35cd402d69626f (MD5) Made available in DSpace on 2014-05-20T13:34:12Z (GMT). No. of bitstreams: 2 S0104-42302011000500018.pdf: 208601 bytes, checksum: 561c73c0c4580446d10fc630a7b24abb (MD5) S0104-42302011000500018.pdf.txt: 20354 bytes, checksum: af7c5799d0257de6eb35cd402d69626f (MD5) Previous issue date: 2011-10-01 OBJETIVO: Avaliar o impacto da urticária crônica na qualidade de vida dos pacientes de ambulatório universitário a partir do questionário DLQI (Dermatology Life Quality Index). MÉTODOS: Inquérito sobre o impacto na qualidade de vida infligido pela urticária crônica a partir do questionário DLQI validado para a língua portuguesa. Pacientes foram entrevistados durante suas consultas em ambulatório especializado, entre maio de 2009 e maio de 2010, em serviço público brasileiro (Botucatu-SP). Os escores do DLQI foram analisados segundo subgrupos: idade, gênero, escolaridade, tempo de doença e presença de angioedema. RESULTADOS: Foram entrevistados 100 pacientes com urticária crônica. Predominou o gênero feminino (86%), a idade média foi de 41,8 anos, duração média da doença foi de seis anos e angioedema ocorreu em 82% dos pacientes. O escore médio do DLQI foi de 13,5, caracterizando grave impacto à qualidade de vida, superior a hanseníase, psoríase, eczema atópico e carcinoma basocelular. Presença de angioedema se associou a maiores escores: 14,5 x 9,9 (p < 0,01). Pacientes do gênero feminino referiram maior impacto quanto ao vestuário, já o gênero masculino referiu quanto ao tratamento, trabalho e estudo (p < 0,05). CONCLUSÃO: Urticária crônica inflige grave comprometimento da qualidade de vida nos pacientes avaliados em serviço universitário brasileiro, especialmente nos portadores de angioedema. OBJECTIVE: To evaluate the impact of chronic urticaria on quality of life of outpatients through the university questionnaire Dermatology Life Quality Index (DLQI). METHODS: Survey of the impact on quality of life caused by chronic urticaria, using the DLQI questionnaire validated for the Portuguese language. Patients were interviewed during visits to a specialized outpatient clinic between May 2009 and May 2010 at a Brazilian public service (Botucatu-SP). DLQI scores were analyzed according to the following subgroups: age, gender, education, disease duration, and presence of angioedema. RESULTS: We interviewed 100 patients with chronic urticaria. There was a female predominance (86%), mean age 41.8 years, mean disease duration of 6 years, and angioedema occurrence in 82% of patients. The mean DLQI score was 13.5, characterized by serious impact on quality of life, higher than Hansen's disease, psoriasis, atopic eczema, and basal cell carcinoma. The presence of angioedema was associated with higher scores: 14.5 x 9.9 (p < 0.01). Female patients reported greater impact on clothing, while male patients reported treatment interference with work and study (p < 0.05). CONCLUSION: Chronic urticaria seriously compromises the quality of life of patients evaluated at a university service in Brazil, particularly of patients with angioedema. Universidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Dermatologia e Radioterapia Universidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Dermatologia e Radioterapia

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:04:13Z No. of bitstreams: 1 S0036-46651992000600013.pdf: 499083 bytes, checksum: 83ac369e564939de13c4cce6afb0c747 (MD5) Made available in DSpace on 2013-08-22T19:04:13Z (GMT). No. of bitstreams: 1 S0036-46651992000600013.pdf: 499083 bytes, checksum: 83ac369e564939de13c4cce6afb0c747 (MD5) Previous issue date: 1992-12-01 Made available in DSpace on 2013-09-30T18:18:53Z (GMT). No. of bitstreams: 2 S0036-46651992000600013.pdf: 499083 bytes, checksum: 83ac369e564939de13c4cce6afb0c747 (MD5) S0036-46651992000600013.pdf.txt: 5 bytes, checksum: cc9067c2ee470dc248b14b194209a34e (MD5) Previous issue date: 1992-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:34:16Z No. of bitstreams: 2 S0036-46651992000600013.pdf: 499083 bytes, checksum: 83ac369e564939de13c4cce6afb0c747 (MD5) S0036-46651992000600013.pdf.txt: 5 bytes, checksum: cc9067c2ee470dc248b14b194209a34e (MD5) Made available in DSpace on 2014-05-20T13:34:16Z (GMT). No. of bitstreams: 2 S0036-46651992000600013.pdf: 499083 bytes, checksum: 83ac369e564939de13c4cce6afb0c747 (MD5) S0036-46651992000600013.pdf.txt: 5 bytes, checksum: cc9067c2ee470dc248b14b194209a34e (MD5) Previous issue date: 1992-12-01 Comunica-se o quarto relato de infecção humana por Microsporum nanum (M. nanun) no Brasil. Trata-se de criança de 9 meses de idade, apresentando há um mês lesões cutâneas dorsais compatíveis com tinea corporis. As lesões foram frustas, regredindo espontaneamente após um mês. A investigação epidemiológica na área de origem do caso índice identificou suínos infectados por Microsporum nanum, sugerindo ser esta a fonte de infecção. The authors present the fourth Brazilian case of human Microsporum nanum (M. nanum) infection. A child of nine months old presents cutaneous dorsal lesions compatible with tinea corporis, which appeared one month before. The culture revealed M. nanum. The lesions resolved spontaneously after a month. Epidemiologic investigation in the patient's place of origin identified swine infected by M. nanum, indicating the probable source of the infection. UNESP Faculdade de Medicina de Botucatu Departamento de Moléstias Infecciosas e Parasitárias, Dermatologia e Radiologia UNESP Faculdade de Medicina de Botucatu Departamento de Moléstias Infecciosas e Parasitárias, Dermatologia e Radiologia

FUNDAMENTOS: Drogas podem desencadear reações adversas. As manifestações cutâneas são as mais comuns. OBJETIVO: Analisar as farmacodermias e relacionar as drogas envolvidas e os tipos de reações cutâneas mais freqüentes. MÉTODOS: Estudo retrospectivo e descritivo. Avaliados pacientes com diagnóstico inicial de farmacodermia internados na Enfermaria de Dermatologia, no período de janeiro de 1999 a junho de 2004. Incluídos no estudo os pacientes que confirmaram o diagnóstico de farmacodermia, com base em critérios clínicos e histopatológicos, após a análise dos prontuários. RESULTADOS: Tiveram diagnóstico inicial de farmacodermia 121 pacientes. Incluídos 43 pacientes, dos quais 51,2% eram do sexo feminino, e 86% da raça branca. Destes, 48,8% faziam uso de apenas uma medicação, sendo o grupo dos antibióticos o mais utilizado (20,9%) e o principal responsável pela farmacodermia(33,3%). O segundo grupo de drogas mais envolvido foi o dos antiinflamatórios (16,7%), seguido pelo dos anticonvulsivantes (13%), e analgésicos/antipiréticos (13%). A forma clínica da erupção cutânea foi exantema maculopapular em 41,9% dos pacientes, eritrodermia em 25,6% e urticária em 23,3%. CONCLUSÃO: O exantema maculopapular foi a principal forma de reação cutânea desencadeada por drogas, e os antibióticos, os medicamentos que mais freqüentemente desencadearam essas reações. BACKGROUND: Drugs may trigger adverse reactions and skin manifestations are the most frequent ones. OBJECTIVE: To assess drug reactions and report the drugs involved and the most frequent types of skin reactions. METHODS: A retrospective and descriptive study. Data of inpatients at the Dermatology Ward with initial diagnosis of adverse drug reactions were evaluated from January 1999 to June 2004. Patients with confirmed diagnosis were included in the study based on clinical and histopathological criteria, after analysis of medical charts. RESULTS: Initial diagnosis of adverse drug reactions was confirmed in 121 patients. Forty-three patients were included in the study; 51.2% were females and 86% were caucasians. A total of 48.8% were on one drug only. Antibiotics were the most commonly used drug (20%) and accounted for 33% of the drug eruptions. The second group comprised anti-inflammatory drugs (16.7%), followed by anticonvulsants (13%), analgesic/antipyretic (13%) agents. Skin eruption manifested as maculopapular exanthema in 41.9% patients, erythrodermia in 25.6%, and urticaria in 23.3%. CONCLUSION: Maculopapular exanthema was the main type of skin reaction triggered by use of drugs, and these reactions were most frequently caused by antibiotics.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:05:55Z No. of bitstreams: 1 S1516-31802007000500006.pdf: 223943 bytes, checksum: 27a4995cd140663036e0867d4dfba435 (MD5) Made available in DSpace on 2013-08-22T19:05:55Z (GMT). No. of bitstreams: 1 S1516-31802007000500006.pdf: 223943 bytes, checksum: 27a4995cd140663036e0867d4dfba435 (MD5) Previous issue date: 2007-09-01 Made available in DSpace on 2013-09-30T18:17:44Z (GMT). No. of bitstreams: 2 S1516-31802007000500006.pdf: 223943 bytes, checksum: 27a4995cd140663036e0867d4dfba435 (MD5) S1516-31802007000500006.pdf.txt: 30055 bytes, checksum: 0fa77d7a8fa2a34f57dc294727bbc51f (MD5) Previous issue date: 2007-09-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:33:40Z No. of bitstreams: 2 S1516-31802007000500006.pdf: 223943 bytes, checksum: 27a4995cd140663036e0867d4dfba435 (MD5) S1516-31802007000500006.pdf.txt: 30055 bytes, checksum: 0fa77d7a8fa2a34f57dc294727bbc51f (MD5) Made available in DSpace on 2014-05-20T13:33:40Z (GMT). No. of bitstreams: 2 S1516-31802007000500006.pdf: 223943 bytes, checksum: 27a4995cd140663036e0867d4dfba435 (MD5) S1516-31802007000500006.pdf.txt: 30055 bytes, checksum: 0fa77d7a8fa2a34f57dc294727bbc51f (MD5) Previous issue date: 2007-09-01 CONTEXTO E OBJETIVO: Urticária-angioedema crônico é enfermidade freqüente, complexa e multicausal. O objetivo foi estudar as características sociodemográficas, clínicas, os fatores causais, agravantes e a evolução da enfermidade. TIPO DE ESTUDO E LOCAL: Descritivo e prospectivo, realizado no ambulatório de Dermatologia da Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (Unesp). MÉTODOS: Foram avaliados pacientes com diagnóstico de urticária-angioedema crônico através de dados sociodemográficos, anamnese, exames dermatológico, clínico e laboratorial, com ênfase nos fatores causais, agravantes e na evolução da enfermidade. RESULTADOS: 125 pacientes foram incluídos, 95 mulheres e 30 homens. Predominaram mulheres de 30 a 40 anos e homens de 10 a 20 anos. A idade média foi de 35 anos para as mulheres e 32 anos para os homens. Predominaram pacientes de raça branca, residentes em zona urbana e casados. O tempo médio de doença foi de 45,6 meses e de cada lesão foi de 5,6 horas. A metade dos casos tinha surtos diariamente e associação de urticária com angioedema. Não houve horário preferencial de aparecimento dos surtos, mas o noturno foi o horário de piora mais citado. A causa foi esclarecida em 37,6%, predominando as infecções. O estresse foi o agravante mais referido. O tempo médio de acompanhamento foi de 11,7 meses e 60% evoluíram para o controle, 32% melhoraram, 9% mantiveram-se inalterados e um caso piorou. CONCLUSÕES: Urticária-angioedema ocorreu mais em mulheres de meia-idade. A causa foi esclarecida em um terço dos pacientes e metade deles teve controle da doença em aproximadamente um ano. CONTEXT and OBJECTIVE: Chronic urticaria-angioedema is a common, multiple-cause complaint. The aim was to investigate the sociodemographic and clinical characteristics, causal and aggravating factors and evolution of urticaria-angioedema. DESIGN and SETTING: This was a descriptive prospective study carried out at the Dermatology outpatient clinic of Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (Unesp). METHODS: A total of 125 patients with chronic urticaria-angioedema were evaluated to obtain sociodemographic data, anamnesis, dermatological and general clinical data and laboratory data, emphasizing causal and aggravating factors and complaint evolution. RESULTS: Chronic urticaria-angioedema occurred mainly in females (mean age: 35 years), but also in men (mean age: 32 years). White color and living in urban areas also predominated. There was no preferential time for symptoms to appear, and nighttime was the most commonly reported time for clinical worsening. Around half of the patients had urticaria associated with angioedema. There were no associated factors in most of the cases, and stress was the most commonly reported aggravating factor. The cause was ascertained in 37.6% of our cases. The mean duration of follow-up was 11.7 months. Around 60% of the patients evolved with the problem under control, 32% improved, 9% had no change in dermatological condition and only one patient worsened. CONCLUSIONS: Chronic urticaria-angioedema was more common among middle-aged women. It is a long-term disease, and its cause was explained in about one-third of the patients. Half of the patients presented disease control after treatment lasting an average of approximately one year. Universidade Estadual Paulista Faculdade de Medicina de Botucatu Hospital das Clínicas Universidade Estadual Paulista Faculdade de Medicina de Botucatu Hospital das Clínicas