23 results on '"Maria Luisa Imaz"'
Search Results
2. Neonatal Feeding Trajectories in Mothers With Bipolar Disorder Taking Lithium: Pharmacokinetic Data
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Maria Luisa Imaz, Klaus Langohr, Mercè Torra, Dolors Soy, Luisa García-Esteve, and Rocio Martin-Santos
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bipolar disorder ,lithium ,breastfeeding ,exclusive maternal breastfeeding ,mixed breastfeeding ,formula feeding ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Purpose: Women who take lithium during pregnancy and continue after delivery may choose to breastfeed, formula feed, or mix these options. The aim of the study was to evaluate the neonatal lithium serum concentrations based on these three feeding trajectories.Methods: We followed 24 women with bipolar disorder treated with lithium monotherapy during late pregnancy and postpartum (8 per trajectory). Lithium serum concentrations were determined by an AVL 9180 electrolyte analyser with a 0.10 mEq/L detection limit and a 0.20 mEq/L limit of quantification (LoQ).Results: There was complete lithium placental passage at delivery, with a mean ratio of lithium concentration in the umbilical cord to maternal serum of 1.12 ± 0.17. The median times to LoQ were 6–8, 7–8, and 53–60 days for formula, mixed, and exclusive breastfeeding respectively. The generalized log-rank testing indicated that the median times to LoQ differ according to feeding trajectory (p = 0.037). According to the multivariate analysis-adjusted lithium serum concentrations at birth, times to LoQ are, on average, longer under exclusive breastfeeding (formula, p = 0.015; mixed, p = 0.012). No lithium accumulation was observed in infants under either exclusive or mixed breastfeeding. During the lactation follow-up, there was no acute growth or developmental delays in any neonate or infant. Indeed, lithium concentrations in the three trajectories declined in all cases. However, the time needed to reach the LoQ was much longer for those breastfeeding exclusively.Conclusions: In breastfeed infant no sustained accumulation of lithium and no adverse effects on development or growth were observed.
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- 2021
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3. Case Report: Clinical and Pharmacokinetic Profile of Lithium Monotherapy in Exclusive Breastfeeding. A Follow-Up Case Series
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Maria Luisa Imaz, Dolors Soy, Mercé Torra, Llüisa García-Esteve, Cristina Soler, and Rocio Martin-Santos
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bipolar disorder ,lithium ,lactation ,case report ,pharmacokinetics ,exclusive maternal breastfeeding ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: Most guidelines advise that women taking lithium should not breastfeed. The variation in transfer is just one reason behind this advice.Objectives: To present clinical and pharmacokinetic data of nine mother–infant pairs exposed to lithium monotherapy during late pregnancy and exclusive breastfeeding at the Perinatal Psychiatric Unit (2006–2018).Methods: We obtained sociodemographic data, medical risk factors, obstetric variables, and family and personal psychiatric history by semi-structured interview, and assessed maternal psychopathology with the Hamilton Depression Rating Scale and Young Mania Rating Scale. A senior neonatologist reviewed neonatal outcomes at birth using the Peripartum Events Scale. Paired maternal and cord blood and infant venous blood samples were collected. During the breastfeeding period, we monitored serum lithium and creatinine concentrations in mother–infant pairs at delivery, and at days 1–5, 7–11, 30, and 60 postpartum, and monthly until 6-months.Results: Lithium equilibrated completely across the placenta [1.13 (0.10), range (1.02–1.30)]. No women presented symptoms of postpartum lithium intoxication, two of the neonates presented transient hypotonia (22%). Lithium exposure was significantly less during breastfeeding than during late pregnancy, and serum lithium concentrations decreased up to 44% overtime from delivery to the first-month, and up to 60% to the third-month postpartum. There was no growth or developmental delay in the follow-up period. One woman had a manic episode with psychotic features at 45 days postpartum.Conclusions: In carefully selected women with bipolar disorder, lithium therapy when breastfeeding can be an appropriate option if coupled with close monitoring of the mother-infant pair.
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- 2021
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4. Clinical Lactation Studies of Lithium: A Systematic Review
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Maria Luisa Imaz, Mercè Torra, Dolors Soy, Lluïsa García-Esteve, and Rocio Martin-Santos
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lithium ,lactation ,breastfeeding ,human milk ,postpartum ,neonates ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: There is substantial evidence that postpartum prophylaxis with lithium lowers the rate of relapse in bipolar disorder. However, it is contraindicated during breastfeeding due to the high variability of the transfer into breast milk.Aims: We conducted a systematic review of the current evidence of studies assessing the transfer of lithium to lactating infants and short-term infant outcomes.Methods: An a priori protocol was designed based on PRISMA guidelines. Searches in PubMed and LactMed were conducted until September 2018. Studies assessing lithium pharmacokinetic parameters and short-term infant outcomes were included. Quality was assessed using a checklist based on international guidelines (i.e., FDA).Results: From 344 initial studies, 13 case reports/series with 39 mother–child dyads were included. Only 15% of studies complied with ≥50% of the items on the quality assessment checklist. Infants breastfeed a mean (SD) of 58.9 (83.3) days. Mean maternal lithium dose was 904 (293) mg/day, corresponding lithium plasma/serum concentration was 0.73(0.26) mEq/L, and breast milk concentration was 0.84(0.14) mEq/L. Mean infant lithium plasma/serum concentration was 0.23(0.26) mEq/L. Twenty-six (80%) infants had concentrations ≤0.30 mEq/L without adverse effects. Eight (20%) showed a transient adverse event (i.e., acute toxicity or thyroid alterations). All of them were also prenatally exposed to lithium monotherapy or polytherapy.Conclusion: The current evidence comes from studies with a degree of heterogeneity and of low-moderate quality. However, it identifies areas of improvement for future clinical lactation studies of lithium and provides support for some clinical recommendations.
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- 2019
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5. Abordaje diagnóstico de los trastornos mentales asociados al maltrato
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García-Esteve, Lluïsa, Giménez, Anna Torres, and Gurrutxaga, María Luisa Imaz
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- 2010
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6. Lithium and Lactation
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Maria Luisa Imaz and Rocio Martin-Santos
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Psychiatry ,RC435-571 - Published
- 2021
7. Interaction between the functional SNP rs2070951 in NR3C2 gene and high levels of plasma corticotropin-releasing hormone associates to postpartum depression
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Estel Gelabert, Teresa Sans, R. Navines, Elisabet Vilella, Roberto Díaz-Peña, Glòria Albacar, L. Garcia-Esteve, Rocío Martín-Santos, Lourdes Martorell, Julio Sanjuán, Maria Luisa Imaz, Angel Carracedo, Alfonso Gutiérrez-Zotes, and Javier Costas
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Postpartum depression ,Adult ,medicine.medical_specialty ,Genotype ,Hydrocortisone ,Corticotropin-Releasing Hormone ,Placenta ,Depression, Postpartum ,03 medical and health sciences ,Corticotropin-releasing hormone ,0302 clinical medicine ,Adrenocorticotropic Hormone ,Pregnancy ,Risk Factors ,Medicine ,Humans ,Longitudinal Studies ,Prospective Studies ,Prospective cohort study ,business.industry ,Obstetrics ,Postpartum Period ,Obstetrics and Gynecology ,medicine.disease ,Neuroticism ,030227 psychiatry ,Psychiatry and Mental health ,Mood ,Receptors, Mineralocorticoid ,Spain ,Female ,business ,030217 neurology & neurosurgery ,Glucocorticoid ,medicine.drug - Abstract
Postpartum depression (PPD) is a common mood disorder that occurs after delivery with a prevalence of approximately 10%. Recent reports have related placental corticotropin-releasing hormone (pCRH) to postpartum depressive symptoms. The aim of this study was to determine whether pCRH, ACTH, and cortisol (measured 48 h after delivery) and glucocorticoid and mineralocorticoid receptor genotypes (NR3C1 and NR3C2) and their interaction are associated with PPD. A longitudinal 32-week prospective study of five hundred twenty-five Caucasian depression-free women that were recruited from obstetric units at two Spanish general hospitals immediately after delivery. Of the women included in the sample, forty-two (8%) developed PPD. A strong association between PPD and the interaction between the pCRH and NR3C2 rs2070951 genotype was observed. The mean level of pCRH in rs2070951GG carriers with PPD was 56% higher than the mean in the CG and CC genotype groups (P
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- 2018
8. Partner Violence Entrapment Scale: Development and Psychometric Testing
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Purificación Navarro, Anna Torres, Maria Jesús Tarragona, Zoe Herreras, Lluïsa Garcia-Esteve, Maria Luisa Imaz, Fernando Gutiérrez, Carlos Ascaso, and Manuel Valdés
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Sociology and Political Science ,Psychometrics ,media_common.quotation_subject ,05 social sciences ,Discriminant validity ,Poison control ,Loneliness ,Test validity ,Exploratory factor analysis ,03 medical and health sciences ,Clinical Psychology ,0302 clinical medicine ,medicine ,Domestic violence ,0501 psychology and cognitive sciences ,030212 general & internal medicine ,medicine.symptom ,Worry ,Psychology ,Law ,Social psychology ,Social Sciences (miscellaneous) ,050104 developmental & child psychology ,media_common ,Clinical psychology - Abstract
This article describes the development and testing of the psychometric properties of the Partner Violence Entrapment Scale (PVES), an instrument that evaluates the women’s perceived reasons for staying in violent partner relationships. After initial pilot testing, the scale was administered to 213 Spanish women who were victims of intimate partner violence (IPV). An exploratory factor analysis identified six factors: Socio-Economic Problems, Attachment and Fear of Loneliness, Blaming Oneself and Resignation, Impact on Children, Fear of Harm and Worry for the Partner, and Feelings of Confusion. Discriminant validity was established by demonstrating associations between PVES factors and socio-demographic, clinical and abuse variables. The scale appears to be a useful assessment tool for social and clinical settings. Its factor structure, reliability, and validity need to be replicated in other populations and samples.
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- 2015
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9. Relationship Between Intimate Partner Violence, Depressive Symptomatology, and Personality Traits
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Purificación Navarro, Manuel Valdés, Anna Torres, Maria Jesús Tarragona, Lluïsa Garcia-Esteve, Anna Plaza, Estel Gelabert, Susana Subirà, Carlos Ascaso, Maria Luisa Imaz, and Rocío Martín-Santos
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medicine.medical_specialty ,Sociology and Political Science ,media_common.quotation_subject ,education ,Human factors and ergonomics ,Poison control ,social sciences ,behavioral disciplines and activities ,Suicide prevention ,Clinical Psychology ,Spouse ,mental disorders ,Injury prevention ,medicine ,population characteristics ,Domestic violence ,Personality ,Big Five personality traits ,Psychology ,Psychiatry ,Law ,Social Sciences (miscellaneous) ,Clinical psychology ,media_common - Abstract
The aim of this study was to examine the relationship between intimate partner violence (IPV) and personality disorder symptoms controlling for depressive state. Victims of IPV (n = 176) and non-abused women (n = 193) completed the Dimensional Assessment of Personality Pathology-Basic Questionnaire (DAPP-BQ), Index of Spouse Abuse (ISA), and Beck Depression Inventory-II (BDI-II). IPV victims scored higher than non-abused women on Intimacy Problems, and scored lower on Rejection traits, after adjustment for depressive symptoms. Severity of the IPV was related to Cognitive Distortion, Suspiciousness, Restricted Expression, and Intimacy Problems, and the length of the IPV was negatively associated with Rejection. The current study suggests only modest differences in personality traits between IPV and non-abused women. The DAPP-BQ traits associated with severity of IPV, in a dose-response manner, would partially reflect the symptoms of complex post-traumatic stress disorder (CPTSD), although this possibility deserves further study.
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- 2013
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10. Childhood physical abuse as a common risk factor for depression and thyroid dysfunction in the earlier postpartum
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Anna Torres, Rocío Martín-Santos, Anna Plaza, Lluïsa Garcia-Esteve, Estel Gelabert, Maria Luisa Imaz, Carlos Ascaso, Manuel Valdés, and Purificación Navarro
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Adult ,Postpartum depression ,Pediatrics ,medicine.medical_specialty ,Thyrotropin ,Thyroid Function Tests ,Thyroid function tests ,Depression, Postpartum ,Risk Factors ,Surveys and Questionnaires ,medicine ,Humans ,Risk factor ,Psychiatry ,Biological Psychiatry ,Depression (differential diagnoses) ,Psychiatric Status Rating Scales ,medicine.diagnostic_test ,Adult Survivors of Child Abuse ,Thyroid ,medicine.disease ,Thyroid Diseases ,Thyroxine ,Psychiatry and Mental health ,Physical abuse ,medicine.anatomical_structure ,Female ,Thyroid function ,Psychology ,Psychopathology - Abstract
Childhood abuse is a powerful risk factor for developing postpartum depression in adulthood, and recently it has been associated to thyroid dysfunction in postpartum depressive women. The purpose of this study was to investigated the effects of childhood abuse on thyroid status and depressive symptomatology in two hundred and thirty-six (n=236) postpartum women 24-48h after delivery. The Early-Trauma-Inventory Self-Report was used to assess the presence of childhood abuse and the Edinburgh Postpartum Depression Scale (EPDS) to evaluate depressive symptomatology (EPDS≥11). Free thyroxin (fT4) and thyroid-stimulating hormone (TSH) were measured. Thyroid dysfunction (TD) was defined as altered TSH or TSH and fT4. Socio-demographic, reproductive, and psychopathological variables were also collected. Multivariate analysis shows that childhood physical abuse increases by four times the risk for TD (OR: 3.95, 95% CI: 1.23-12.71) and five times the risk for depressive symptomatology (OR: 5.45, 95% CI: 2.17-13.66) in the earlier postpartum. Our findings suggest that women with history of childhood physical abuse are particularly at-risk for thyroid dysfunction and depressive symptomatology 24-48h after delivery. The assessment of childhood abuse in the perinatal period is important to identify women at-risk for physical and mental health problems in this period.
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- 2012
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11. Validación y comparación de cuatro instrumentos para la detección de la violencia de pareja en el ámbito sanitario
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Manuel Valdés, Maria Luisa Imaz, Lluïsa Garcia-Esteve, Purificación Navarro, Anna Torres, Zoe Herreras, and Carlos Ascaso
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Validation study ,Injury control ,business.industry ,Accident prevention ,Primary health care ,Poison control ,Medicine ,Diagnostic accuracy ,General Medicine ,Atencion primaria ,business ,Humanities ,Mass screening - Abstract
Resumen Fundamento y objetivo Estudio de la validacion externa y comparacion de la precision diagnostica y concordancia de cuatro instrumentos para la identificacion de la violencia de pareja (VP) en el ambito sanitario: Index of Spouse Abuse (ISA), Psychological Maltreatment of Women Inventory short form (PMWI-SF), Woman Abuse Screening Tool (WAST), Partner Violence Screen (PVS). Sujetos y metodo Estudio de casos y controles. La muestra se recluto en centros de asistencia primaria y centros especializados en VP. Completaron los cuestionarios ISA, PMWI-SF, WAST y PVS un total de 223 mujeres sin maltrato (controles) y 182 con maltrato de pareja (casos). Se evaluo la precision diagnostica mediante la estimacion por intervalo del area bajo la curva ROC, se compararon las areas bajo la curva (ABC) y se realizo un analisis de la concordancia entre ellos. Resultados Los valores de ABC fueron: ISA 0,99 (intervalo de confianza del 95% [IC 95%] 0,98-0,99), PMWI-SF 0,98 (IC 95% 0,97-0,99), WAST 0,95 (IC 95% 0,93-0,97), PVS 0,91 (IC 95% 0,87-0,94). La concordancia entre los cuatro cuestionarios fue excelente (Kappa de Fleiss = 0,82). Los valores del ABC del ISA y el PMWI-SF fueron significativamente mayores que el del WAST, y los tres obtuvieron un mejor funcionamiento que el PVS. El PVS fue el cuestionario que obtuvo menor concordancia con el resto. Conclusiones Todos los cuestionarios estudiados obtuvieron un buen funcionamiento global para la deteccion de la VP y una alta concordancia entre ellos. La sensibilidad puede estar sobreestimada debido a la distinta procedencia de los casos.
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- 2011
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12. Validation and Test-Retest Reliability of Early Trauma Inventory in Spanish Postpartum Women
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James Douglas Bremner, Purificación Navarro, Lluïsa Garcia-Esteve, Anna Plaza, Maria Luisa Imaz, Rocío Martín-Santos, Manuel Valdés, Estel Gelabert, and Anna Torres
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Adult ,Postpartum depression ,medicine.medical_specialty ,Psychometrics ,Intraclass correlation ,Article ,Depression, Postpartum ,Life Change Events ,Young Adult ,Surveys and Questionnaires ,Confidence Intervals ,medicine ,Humans ,Young adult ,Psychiatry ,Depression (differential diagnoses) ,Obstetrics ,Adult Survivors of Child Abuse ,Postpartum Period ,Case-control study ,Area under the curve ,Reproducibility of Results ,medicine.disease ,Confidence interval ,Psychiatry and Mental health ,ROC Curve ,Spain ,Area Under Curve ,Case-Control Studies ,Female ,Psychology - Abstract
The aims were to study the validity and test-retest reliability of the Early Trauma Inventory—Self Report (ETI-SR) and its short-form (ETI-SF), which retrospectively assess different childhood trauma, in a sample of Spanish postpartum women. A total of 227 healthy postpartum women completed the ETI-SR and ETI-SF. The longitudinal, expert, all data procedure was used as the external criterion for the assessment of childhood trauma. The ETI-SR and ETI-SF were also administered to a sample of 102 postpartum depressive women (DSM-IV) and the results were compared with those of the healthy postpartum sample. The area under the curve values of the ETI-SR and ETI-SF were 0.77 (95% confidence interval [CI], 0.71–0.84) and 0.78 (95% CI, 0.72–0.85), the internal consistencies of the 2 scales were 0.79 and 0.72, and the intraclass correlation coefficients were 0.92 (95% CI, 0.80–0.97) and 0.91 (95% CI, 0.78–0.96), all respectively. The ETI-SR and ETI-SF had higher test-retest reliability on all subscales. The ETI-SR and ETI-SF are shown to be valid and reliable instruments for assessing childhood trauma in postpartum women.
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- 2011
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13. The Vulnerable Personality Style Questionnaire: psychometric properties in Spanish postpartum women
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Susana Subirà, Maria Luisa Imaz, Purificación Navarro, Anna Torres, Anna Plaza, Rocío Martín-Santos, Lluïsa Garcia-Esteve, Manuel Valdés, and Estel Gelabert
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Adult ,Postpartum depression ,medicine.medical_specialty ,Adolescent ,Psychometrics ,media_common.quotation_subject ,Depression, Postpartum ,Young Adult ,Cronbach's alpha ,Surveys and Questionnaires ,medicine ,Humans ,Personality ,Psychiatry ,media_common ,Postpartum Period ,Obstetrics and Gynecology ,Construct validity ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Logistic Models ,Spain ,Edinburgh Postnatal Depression Scale ,Personality style ,Harm avoidance ,Female ,Temperament and Character Inventory ,Psychology ,Clinical psychology - Abstract
The Vulnerable Personality Style Questionnaire (VPSQ) is a nine-item self-report scale developed to asses personality traits which increase the risk of postpartum depression. The aim of the present study was to examine the psychometric properties of the Spanish version of the VPSQ in a sample of postpartum women. A cohort of 309 postpartum women was followed up for 32 weeks after delivery. All women were assessed with the Spanish version of the VPSQ, the Eysenck Personality Questionnaire-R Short Scale, the Frost Multidimensional Perfectionism Scale and the harm avoidance dimension of the Temperament and Character Inventory at 2-3 days postpartum. Depressive symptoms were evaluated at 8 and 32 weeks after delivery by the Edinburgh Postnatal Depression Scale, and a diagnostic interview was used to confirm the presence of major depression disorder. Factor analysis results revealed the unidimensionality of the Spanish version of the VPSQ. Cronbach's alpha coefficient for the VPSQ total score was 0.63. The test-retest reliability indicated a good temporal stability (ICC = 0.88; 95% confidence interval (CI) = 0.82-0.91). A moderate association between the VPSQ and other personality measures provided evidence for its construct validity. Logistic regression analyses showed that women with higher scores on the VPSQ had a higher risk of developing depressive symptoms (OR = 1.20; 95% CI = 1.11-1.29) and major depression (OR = 1.16; 95% CI = 1.07-1.26) throughout the 32 weeks after delivery. Overall, our results suggest adequate psychometric properties of the Spanish version of the VPSQ and its usefulness in identifying women with a personality style that increases the risk of developing postpartum depression.
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- 2010
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14. Detecting Domestic Violence: Spanish External Validation of the Index of Spouse Abuse
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Anna Torres, Maria Jesús Tarragona, Zoe Herreras, Maria Luisa Imaz, Rocío Martín-Santos, Alba Roca, Purificación Navarro, Susana Subirà, Estel Gelabert, Carlos Ascaso, and Lluïsa Garcia-Esteve
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Sociology and Political Science ,Human factors and ergonomics ,Poison control ,Occupational safety and health ,Confirmatory factor analysis ,Exploratory factor analysis ,Clinical Psychology ,Spouse ,Injury prevention ,Domestic violence ,Psychology ,Law ,Social psychology ,Social Sciences (miscellaneous) - Abstract
The aims of the study were to assess the psychometric properties of the Spanish version of the Index of Spouse Abuse (ISA), and to validate it against external criteria of intimate partner violence. The Spanish version of the ISA was administered to 223 non-abused women and 182 victims of intimate partner violence. Internal consistency coefficients oscillated between 0.88 and 0.98. The Confirmatory Factor Analysis failed to replicate the original two-factor structure. Using Exploratory Factor Analysis, a two-factor solution was found: physical (ISA-P) and non-physical (ISA-NP), but the items included in each factor were slightly different from the original two subscales. Receiver operating characteristic curve analysis revealed an AUC value for the ISA global score of 0.99 (95% CI: 0.98–0.99), with the optimal cut-off of 12 for detecting intimate partner violence. The Spanish version of the ISA is a valid instrument for detecting intimate partner violence in a female population.
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- 2009
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15. Maladaptive family dysfunction and parental death as risk markers of childhood abuse in women
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Purificación Navarro, Manuel Valdés, Maria Luisa Imaz, Anna Torres, Lluïsa Garcia-Esteve, Estel Gelabert, Carlos Ascaso, Anna Plaza, and Rocío Martín-Santos
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Adult ,Linguistics and Language ,medicine.medical_specialty ,Adolescent ,Family Conflict ,Dysfunctional family ,Language and Linguistics ,Parental Death ,Young Adult ,Risk Factors ,Surveys and Questionnaires ,medicine ,Humans ,Psychiatry ,Psychological abuse ,Child ,General Psychology ,Adult Survivors of Child Abuse ,Child Abuse, Sexual ,Middle Aged ,Mental illness ,medicine.disease ,Substance abuse ,Physical abuse ,Sexual abuse ,Child, Preschool ,Female ,Psychology ,Postpartum period ,Clinical psychology - Abstract
This study aims to examine the prevalence and characteristics of physical, emotional and sexual childhood abuse. It also examines whether other non-abuse types of childhood adversities related to maladaptive family functioning and separations during childhood can be used as markers for the presence of childhood abuse. Participants (N = 237) were women at 2–3 days after delivery that completed the Spanish-validated version of the Early Trauma Inventory Self Report (ETI-SR; Bremner, Bolus, & Mayer, 2007; Plaza et al., 2011), designed to assess the presence of childhood adversities. Results show that 29% of the women had experienced some type of childhood abuse, and 10% more than one type. Logistic regression analyses indicate that childhood parental death is a risk marker for childhood emotional abuse (OR: 3.77; 95% CI: 1.327–10.755; p OR: 3.72; 95% CI: 1.480–9.303; p < .005) and physical abuse (OR: 2.610; 95% CI: 1.000–6.812; p < .05) and that childhood family mental illness is a risk marker for childhood emotional (OR: 2.95; 95% CI: 1.175–7.441; p < .021) and sexual abuse (OR: 2.55; 95% CI: 1.168–5.580; p < .019). The high prevalence of childhood abuse indicates a need for assessment during the perinatal period. Screening for childhood family mental illness, parental substance abuse, and parental death - all identified risk factors for reporting childhood abuse - can help to identify women that should be assessed specifically regarding abuse.
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- 2015
16. Plasma levels of oral risperidone during enteral nutrition in a pregnant schizophrenic patient
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Lucila Barbosa, Maria Luisa Imaz, G. Oriolo, Eduard Parellada, Sergi Borrego, and Luisa Garcia
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Pediatrics ,medicine.medical_specialty ,Pregnancy ,Risperidone ,Clinical pharmacology ,business.industry ,medicine.medical_treatment ,medicine.disease ,Enteral administration ,Surgery ,law.invention ,Route of administration ,Parenteral nutrition ,Pharmacokinetics ,law ,medicine ,Psychology (miscellaneous) ,Antipsychotic ,business ,Letters to the Editor ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,medicine.drug - Abstract
Antipsychotic (AP) medication in pregnant women has always been a complex and controversial clinical challenge. On the one hand, this is due to possible adverse pregnancy outcomes for both the mother and child, that is, premature births, poor neonatal adaptation signs and higher rates of congenital malformation [Sadowski et al. 2013]. On the other hand, composite pharmacological interactions related to physiological changes that occur during pregnancy increase the difficulties in drug management. The augmentation of plasmatic volume, the reduction in albumin concentration, the increase of glomerular filtration and the modifications in hepatic metabolism are some of the factors that affect the pharmacokinetics of APs in pregnant women [Anderson, 2005]. Furthermore, the route of administration of a drug is a well-known factor that affects its absorption and distribution with direct consequences on plasmatic concentration and therapeutic effects. Among these latter effects, drug administration by nasogastric tube (NGT) is of particular interest in clinical pharmacology. Enteral feeding is a common condition among patients receiving long-term care as well as among psychiatric patients with rejection of food intake. Inappropriate prescribing behaviour together with incorrect procedures for drug delivery may result in significant harm to patients [Zhu and Zhou, 2013]. Unfortunately, there are virtually no data available on the pharmacokinetics of APs, such as risperidone, administered by NGT. Therefore, we believe it is important to share our findings in order to better address the management of APs during pregnancy and give impulse to further research on pharmacokinetics when administered by NGT.
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- 2015
17. Comparative Hemodynamic Effects of Urapidil and Labetalol After Electroconvulsive Therapy
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Purificacion Santos, Graciela Martinez-Palli, R. Navines, Jordi Blanch, Miguel Bernardo, Maria-Luisa Imaz, Adela Fauli, Carmen Gomar, and José-Manuel Arcega
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Adult ,Male ,Haemodynamic response ,medicine.medical_treatment ,Adrenergic beta-Antagonists ,Neuroscience (miscellaneous) ,Hemodynamics ,Urapidil ,Piperazines ,Electroconvulsive therapy ,Heart Rate ,Convulsion ,Heart rate ,medicine ,Humans ,Labetalol ,Electroconvulsive Therapy ,Adrenergic alpha-Antagonists ,Aged ,Dose-Response Relationship, Drug ,Electroencephalography ,Middle Aged ,Psychiatry and Mental health ,Blood pressure ,Anesthesia ,Hypertension ,Female ,medicine.symptom ,Psychology ,medicine.drug - Abstract
Urapidil, a postsynaptic alpha 1 -adrenergic antagonist, has been reported to improve intraoperative hemodynamic stability, although it has never been used to prevent the hemodynamic response of electroconvulsive therapy (ECT). This study was designed to evaluate the clinical effectiveness of urapidil, as an alternative to labetalol, in preventing the hemodynamic response of ECT. Twenty-seven patients undergoing a series of six consecutive ECT treatments were studied. Each patient received all three pretreatments twice: no drug, labetalol 0.2 mg/kg, or urapidil 25 mg. Systolic, diastolic, and mean blood pressure and heart rate (HR) were recorded during the awake state, after anesthesia induction, and 1, 2, 5, 10 and 30 minutes after electroencephalographic (EEG) seizure ended. The duration of the EEG convulsion was also recorded. After induction, the HR increased for no drug and urapidil pretreatments, whereas it decreased when labetalol was given. Labetalol and urapidil attenuated the peak increase of blood pressure and returned it to earlier baseline values. There were no differences in the duration of EEG convulsion between the three pretreatments. Urapidil seems to be a good alternative to labetalol for attenuating the hypertensive response to ECT in cases where there is a contraindication to beta-antagonists.
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- 2001
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18. An increased hypothermic response to buspirone in patients with major depression
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Maria Luisa Imaz, Cristóbal Gastó, Esther Gómez-Gil, Ricard Navinés, Rocío Martín-Santos, and María J. Martínez de Osaba
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Adult ,Male ,Pharmacology ,Agonist ,Depressive Disorder, Major ,medicine.drug_class ,Pharmacology toxicology ,Hypothermia ,Serotonin 5-HT1 Receptor Agonists ,Buspirone ,Serotonin Receptor Agonists ,Cross-Sectional Studies ,Case-Control Studies ,Anesthesia ,medicine ,Humans ,Female ,In patient ,medicine.symptom ,Psychology ,Depression (differential diagnoses) ,medicine.drug - Published
- 2006
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19. Are women with a history of abuse more vulnerable to perinatal depressive symptoms? A systematic review
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L. Hermida-Barros, M. Alvarez-Segura, Maria Luisa Imaz, L. San, Anna Plaza, L. Garcia-Esteve, N. Burtchen, and Anna Torres
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Child abuse ,medicine.medical_specialty ,MEDLINE ,Poison control ,PsycINFO ,Cochrane Library ,Vulnerable Populations ,Depression, Postpartum ,Stress Disorders, Post-Traumatic ,Pregnancy ,Risk Factors ,medicine ,Prevalence ,Humans ,Child Abuse ,Psychiatry ,Child ,business.industry ,Obstetrics and Gynecology ,Mental health ,Psychiatry and Mental health ,Perinatal Care ,Mental Health ,Domestic violence ,Female ,business ,Perinatal Depression - Abstract
The objective of this paper is to examine the association between maternal lifetime abuse and perinatal depressive symptoms. Papers included in this review were identified through electronic searches of the following databases: Pubmed Medline and Ovid, EMBASE, PsycINFO, and the Cochrane Library. Each database was searched from its start date through 1 September 2011. Keywords such as “postpartum,” “perinatal,” “prenatal,” “depression,” “violence,” “child abuse,” and “partner abuse” were included in the purview of MeSH terms. Studies that examined the association between maternal lifetime abuse and perinatal depression were included. A total of 545 studies were included in the initial screening. Forty-three articles met criteria for inclusion and were incorporated in this review. Quality of articles was evaluated with the Newcastle-Ottawa-Scale (NOS). This systematic review indicates a positive association between maternal lifetime abuse and depressive symptoms in the perinatal period.
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- 2014
20. Long-term and bizarre self-injurious behavior: an approach to underlying psychological mechanisms and management
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Fernando Gutiérrez, Mireia Vázquez, Maria Luisa Imaz, David A. Kahn, Rocío Martín-Santos, Jose Moreno-España, Victòria Soler, Ricard Navinés, Juan C. Pascual, and Belén Arranz
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Adult ,Psychotherapist ,Poison control ,Suicide, Attempted ,medicine.disease ,Foreign Bodies ,Suicide prevention ,Personality disorders ,Malingering ,Intervention (counseling) ,Injury prevention ,medicine ,Humans ,Female ,Psychology ,Borderline personality disorder ,Self-Injurious Behavior ,Psychopathology - Abstract
Repeated self-harm usually presents with associated psychopathology, mostly in the form of obsessive-compulsive disorder, malingering, or personality disorders, and may persist for many years. This case presentation focuses on self-harm involving the deliberate ingestion of foreign bodies. This behavior remains poorly understood, and the relevant literature focuses almost entirely on gastroenterological and surgical management, with little or no discussion of underlying psychological mechanisms, psychopathology, or psychotherapeutic intervention. The goal of this article is to begin to fill that gap by presenting the case of a young woman who was diagnosed with borderline personality disorder and followed for 20 years, who repeatedly swallowed objects as a form of self-harming behavior. The nosological status and possible functions of this behavior are discussed, as are the difficulties of caring for patients with such long-standing, repeated selfinjury. This case illustrates how the boundaries between different self-injurious behaviors are blurred and also how different self-injurious behaviors are likely to share common patterns, functional integrity, and meanings. It should also serve to remind us how far we have to go in terms of understanding, classifying, and successfully treating certain patients who present with longterm and bizarre self-injurious behavior. (Journal of Psychiatric Practice 2013;19:65-71). Language: en
- Published
- 2013
21. Avances en la psicofarmacología perinatal
- Author
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María Luisa Imaz
- Subjects
Psicofármacos ,Embarazo ,Posparto ,Farmacocinética ,Psychology ,BF1-990 ,Psychiatry ,RC435-571 - Published
- 2021
- Full Text
- View/download PDF
22. PSYCHOSIS AND INMIGRATION. DIFFERENCES ACCORDING TO ORIGIN
- Author
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Angeles Malagón, José María Ginés, Carles Garcia-Ribera, Antoni Bulbena, Maria Luisa Imaz, and Juan C. Pascual
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Psychiatry and Mental health ,Psychosis ,medicine.medical_specialty ,medicine ,medicine.disease ,Psychiatry ,Psychology ,Biological Psychiatry - Published
- 2008
- Full Text
- View/download PDF
23. Dual diagnosis in the psychiatric emergency room in Spain
- Author
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Rocío Martín-Santos, Ricard Navinés, José María Ginés, Francina Fonseca, Maria Luisa Imaz, Antònia Domingo-Salvany, Marta Torrens, and Juan C. Pascual
- Subjects
emergency room ,Pediatrics ,medicine.medical_specialty ,Referral ,business.industry ,evaluation of services ,Emergency department ,Logistic regression ,Psychiatry and Mental health ,Psychiatric history ,psychiatric comorbidity ,Rating scale ,psychiatric emergency services ,Severity of illness ,Medicine ,Dual diagnosis ,severity of illness ,business ,Psychiatry ,Substance abuse disorder - Abstract
Background and Objectives: Dual diagnosis is associated with increased emergency department service use. During recent years, increased emphasis has been given to monitor the decision to hospitalise the most sever patients. Many rating scales have developed based on patient-related factors. To assess the level of severity of dual diagnosis patients measured by the Severity Psychiatric Illness (SPI) Scale and to evaluate it as a tool for predicting discharge in emergency psychiatric practice. Methods: Data on 1,227 consecutive admissions visited in a psychiatric emergency room of a genera] teaching hospital during a period of six months were collected. A routine computerised protocol was completed which included socio-demographic, clinical and social factors and the SPI scale. Results: 206 admissions (17%) had dual diagnosis disorder, 106 (9%) had substance abuse disorder (SUD), and 906 (74%) had non-substance abuse disorder (NSUD). Differences among groups were found in clinical characteristics, discharge decision, readmissions, previous psychiatric history, reason for referral, DSM-IV diagnosis and illicit drug use. Dual diagnosed patients had the highest scores of severity. Logistic regression analyses revealed the independent contribution of different SPI'items. The model showed a good fit and indicated excellent calibration in the sample studied, predicting 87.6% of discharge decisions. Conclusions: Dual diagnosed patients at the emergency psychiatric room presented the highest levels of severity both in clinical and social problems. While the SPI was a good tool for assessing severity of illness in our patients, only some dimensions predicted discharge decision.
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