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Cubiu, an Amazonian fruit, is widely used as food and popular treatment for pathologies that present an inflammatory pattern, such as skin wound healing. However, there is still no confirmation in the scientific literature about the safety profile, as well as the anti-inflammatory, antioxidant, and healing actions of cubiu. This study is divided into two experimental protocols using Wistar rats. Thus, the first objective (protocol 1) of this study was to evaluate the toxicity of an oral administration of cubiu extract at different doses for 28 days. The macroscopic and microscopic analyses of the liver and kidney were performed, and the following analysis was determined in plasma: glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyl transpeptidase, glucose, triglycerides, total cholesterol, urea, creatinine, and uric acid. After, we conducted the second protocol aimed to establish the potential antioxidant and anti-inflammatory capacity of cubiu and its interaction with magnetic field in skin wound healing. On days 3, 7, and 14 of treatment, skin and blood samples were collected and analyzed: the oxidative stress biomarkers (reactive substances to thiobarbituric acid, nonprotein thiols, superoxide dismutase, catalase, and glutathione S-transferase), myeloperoxidase enzymatic activity, and cytokines levels (interleukin 1, interleukin 6, interleukin 10, and tumor necrosis factor-alpha). The cubiu has shown to be safe and nontoxic. Both cubiu and magnetic field promoted decreased levels of proinflammatory and prooxidant biomarkers (interleukin 1, interleukin 6, tumor necrosis factor-alpha, and reactive substances to thiobarbituric acid), as well as increased levels of anti-inflammatory and antioxidant biomarkers (interleukin 10, nonprotein thiols, and superoxide dismutase), with greater potential when treatments are used in association. Thus, cubiu promotes antioxidant and anti-inflammatory action in skin wound healing, while also improving results of the conventional treatment for skin healing (magnetic field) when used in association.

Estudos demonstram que cuidados com a exposição ao sol adotados desde a infância reduzem o desenvolvimento do câncer de pele. Pesquisas indicam que no ambiente escolar as atividades lúdicas favorecem a obtenção, construção e retenção do conhecimento. Além disso, estas favorecem o desenvolvimento social, pessoal e cultural, facilitando a comunicação e expressão científica. O objetivo desse artigo é relatar a experiência da aplicação do jogo intitulado “Fala sério” ou “Com certeza” sobre câncer de pele, para alunos do ensino fundamental de uma escola pública de Jaguari/RS. A ação foi gravada e o material foi utilizado para a análise dos resultados. Verificou-se que a dinâmica do jogo oportunizou um espaço de discussão e reflexão a respeito das causas, prevenção e importância do diagnóstico precoce do câncer de pele e favoreceu a troca experiências, estimulando a participação ativa dos estudantes na construção do conhecimento. Dessa forma, permitiu aos participantes melhorar seu nível de conhecimento sobre o tema abordado, o que pode interferir em comportamentos mais saudáveis quando expostos ao sol. Sendo assim, o uso de atividades lúdicas contribui de maneira efetiva/transformadora na prática da promoção de saúde, pois poderá despertar nos estudantes a capacidade de desenvolver habilidades e atitudes imprescindíveis para participar ativamente dos acontecimentos na comunidade em que vivem e atuar nas decisões do dia-a-dia, de forma consciente e crítica. Assim, pretende-se contribuir para a redução das taxas de ocorrência e morte por câncer de pele dos alunos, de seus familiares e de toda a comunidade que os cerca. Palavras-chave: Ensino de Ciências, Alfabetização Científica; Recurso Pedagógico; Promoção de Saúde; Exposição Solar "Speak Seriously” or "For Sure" about skin cancer - the use of playful activities in elementary school: An experience report Abstract: Studies show that sun exposure care adopted since childhood reduces the development of skin cancer. Research indicates that in the school environment, recreational activities promote the acquisition, construction, and retention of knowledge. In addition, these provide social, personal, and cultural development, facilitating communication and scientific expression. The objective of this article is to report the experience of the application of the game entitled Seriously or Certainly about skin cancer, for students of a public school in Jaguari, Rio Grande do Sul State, Brazil. The intervention was recorded and used for the analysis of the results. It was found that the dynamics of the game provided a space for discussion and reflection on the causes, prevention, and importance of early diagnosis of skin cancer. It also supported the exchange of experiences and the encouragement of active participation of students in the construction of knowledge. Thus, the activity allowed the participants to improve their level of knowledge of the proposed theme, which can interfere with healthier behaviors when exposed to the sun. Therefore, the use of playful activities contributes effectively to the practice of health promotion. In addition, it also encourages students to develop the skills and attitudes required to actively participate in events in their community and to act consciously and critically in daily decisions. Thus, it is intended to contribute to reducing the rates of occurrence and death from skin cancer, among students, their families, and the entire community that surrounds them. Keywords: Science Teaching; Scientific Literacy; Pedagogical Resource; Health Promotion; Sun Exposure

O câncer de pele é provocado pelo crescimento anormal e descontrolado de células que compõem a pele, acometendo milhares de pessoas a cada ano no Brasil. Estudos demonstram que as possibilidades de desenvolvimento do câncer de pele são reduzidas se os cuidados com a exposição solar forem adotados desde a infância. Sendo assim, o objetivo deste estudo foi analisar as possíveis contribuições do uso de diferentes recursos pedagógicos relacionados ao ensino do tema câncer de pele entre alunos do ensino fundamental de três escolas públicas da região central do estado do RS. Participaram da pesquisa 139 estudantes com idades entre 8 e 13 anos. Os recursos pedagógicos utilizados para a realização das oficinas foram uma cartilha, um folder e um flyer, com ilustrações e atividades a respeito do tema câncer de pele e os meios de prevenção. Os instrumentos de coleta de dados foram o diário de campo e a entrevista semiestruturada. O tratamento dos dados foi baseado em análise de conteúdo e estatística descritiva. Observou-se que os recursos pedagógicos utilizados despertaram o interesse dos estudantes em aprender sobre o tema proposto e foram eficientes para iniciar o processo de alfabetização científica relacionado às funções da pele, desenvolvimento do câncer de pele e fatores que influenciam seu surgimento. Acredita-se que esses recursos contemplaram o primeiro eixo estruturante da alfabetização científica, que se refere à compreensão básica de termos, conhecimentos e conceitos fundamentais que conduzem o aluno a compreender conceitos científicos de forma a significá-los em suas vivências cotidianas.

Cubiu, an Amazonian fruit, is widely used as food and popular treatment for pathologies that present an inflammatory pattern, such as skin wound healing. However, there is still no confirmation in the scientific literature about the safety profile, as well as the anti-inflammatory, antioxidant, and healing actions of cubiu. This study is divided into two experimental protocols using Wistar rats. Thus, the first objective (protocol 1) of this study was to evaluate the toxicity of an oral administration of cubiu extract at different doses for 28 days. The macroscopic and microscopic analyses of the liver and kidney were performed, and the following analysis was determined in plasma: glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyl transpeptidase, glucose, triglycerides, total cholesterol, urea, creatinine, and uric acid. After, we conducted the second protocol aimed to establish the potential antioxidant and anti-inflammatory capacity of cubiu and its interaction with magnetic field in skin wound healing. On days 3, 7, and 14 of treatment, skin and blood samples were collected and analyzed: the oxidative stress biomarkers (reactive substances to thiobarbituric acid, nonprotein thiols, superoxide dismutase, catalase, and glutathione S-transferase), myeloperoxidase enzymatic activity, and cytokines levels (interleukin 1, interleukin 6, interleukin 10, and tumor necrosis factor-alpha). The cubiu has shown to be safe and nontoxic. Both cubiu and magnetic field promoted decreased levels of proinflammatory and prooxidant biomarkers (interleukin 1, interleukin 6, tumor necrosis factor-alpha, and reactive substances to thiobarbituric acid), as well as increased levels of anti-inflammatory and antioxidant biomarkers (interleukin 10, nonprotein thiols, and superoxide dismutase), with greater potential when treatments are used in association. Thus, cubiu promotes antioxidant and anti-inflammatory action in skin wound healing, while also improving results of the conventional treatment for skin healing (magnetic field) when used in association.

The aim of the present study was to evaluate the associations of metabolic disorders and anthropometric and biochemical biomarkers of lipid, glucose and oxidative metabolism and the habitual ingestion of guaraná (Paullinia cupana, Mart. Var. sorbilis) by an elderly population residing in the Amazon Riverine region of the Maués municipality (Brazil). A case-controlled study was performed that included 637 elderly (≥60 years of age) patients classified as either those who habitually drank guaraná (GI, n = 421) or those who never drank guaraná (NG, n = 239) based upon their self-reported intake of guaraná. Indeed, the prevalence of various metabolic disorders was associated with guaraná ingestion. The prevalence of hypertension, obesity and metabolic syndrome in the GI group was lower than the prevalence found in the NG group. The NG group exhibited lower systolic and diastolic blood pressure values. The males in the GI group exhibited a lower waist circumference, on average, than the circumference found in the NG group, whereas the females in the GI group had lower cholesterol (total and LDL-c) levels than the control cohort. Additionally, a significant association was found between lower levels of advanced oxidative protein product (AOPP) and habitual guaraná consumption. The results constitute the first epidemiological study to suggest a potentially protective effect of habitual guaraná ingestion against metabolic disorders in elderly subjects.

A one hypothesis to explain some vestibular peripheral disorders is their association with life style. Thus, studies with young adults are relevant.to analyze the prevalence of dynamic balance alterations in young adults and their possible association with life style variables, health and negative emotional states (since they can impact the outcome).we carried out a non-probabilistic cross-sectional, clinical-retrospective study with young adults (18-32 years of age) from a university with 751 individuals, with a mean age of 22.45+/- 3.32 years. Life style, health and negative emotional states (NES) variables - depression, stress and anxiety, were collected by means of an interview. The Unterberger test was used in order to check for indications of dynamic balance alterations. Individuals with altered dynamic balance (ADB) were compared to those without these alterations (controls).From our sample, 642 (83.6%) had less than 45 masculine of deviation, while 109 (14.2%) had greater than 45 masculine deviation and were the considered with ADB. The ADB group had a greater prevalence of smoking, alcohol abuse/dependence, high blood pressure and NES.the study highlights the occurrence of ADB which needs to be corroborated in future studies.

Blueberry is a polyphenol-rich fruit bearing great bioactive potential. Natural deep eutectic solvents (NADES) emerged as putatively biocompatible solvents that could substitute for toxic organic solvents in the extraction of fruit phenolic compounds for developing nutraceuticals or functional foods. Therefore, the aim of this study was to investigate the gastroprotective effects and the biocompatibility of a blueberry crude extract (CE) obtained using NADES and of the extract fractions (anthocyanin-rich fraction ? ARF; non-anthocyanin phenolic fraction - NAPF) in a model of ethanol-induced gastric ulcer in rats. CE was the NADES-containing, ready-to-use extract that was obtained using choline chloride:glycerol:citric acid NADES (0.5:2:0.5 M ratio). ARF and NAPF were the NADES-free fractions obtained by solid phase purification of CE and were investigated to identify the bioactive fraction responsible for the effects of CE. Animals were treated for 14 days with water, NADES vehicle, CE, ARF, NAPF or lansoprazole (intragastric) and then received ethanol to induce gastric ulcer. CE decreased ulcer index and preserved the integrity of gastric mucosa. The pretreatment with CE or ARF reduced glutathione depletion and the inflammatory response. All treatments, including NADES vehicle reduced protein oxidation and nitric oxide overproduction in ethanol-treated rats. Additionally, ARF increased short-chain fatty acids in feces. These findings suggest that NADES can be used to obtain biocompatible extracts of blueberry that exhibit gastroprotective effects with no need of solvent removal. The gastroprotective effects were mainly associated to ARF but NAPF and even NADES vehicle also contributed to some protective effects. Made available in DSpace on 2020-12-04T09:06:43Z (GMT). No. of bitstreams: 1 Natural-deep-eutectic-solvent.pdf: 4564862 bytes, checksum: db1db40a12d74b8fafa46afe08f2fa71 (MD5) Previous issue date: 2020