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8. Perceived helpfulness of treatment for posttraumatic stress disorder: Findings from the World Mental Health Surveys

Author

Stein, Dan J., Harris, Meredith G., Vigo, Daniel V., Tat Chiu, Wai, Sampson, Nancy, Alonso, Jordi, Altwaijri, Yasmin, Bunting, Brendan, Caldas-de-Almeida, José Miguel, Cía, Alfredo, Ciutan, Marius, Degenhardt, Louisa, Gureje, Oye, Karam, Aimee, Karam, Elie G., Lee, Sing, Medina-Mora, Maria Elena, Mneimneh, Zeina, Navarro-Mateu, Fernando, Posada-Villa, José, Rapsey, Charlene, Torres, Yolanda, Carmen Viana, Maria, Ziv, Yuval, Kessler, Ronald C., Aguilar-Gaxiola, Sergio, Al-Hamzawi, Ali, Salih Al-Kaisy, Mohammed, Helena Andrade, Laura, Atwoli, Lukoye, Benjet, Corina, Borges, Guilherme, Bromet, Evelyn J., Bruffaerts, Ronny, Cardoso, Graça, Chatterji, Somnath, Cia, Alfredo H., Demyttenaere, Koen, Florescu, Silvia, de Girolamo, Giovanni, Maria Haro, Josep, Hinkov, Hristo, Chi-Hu, yi, de Jonge, Peter, Nasser Karam, Aimee, Kawakami, Norito, Kiejna, Andrzej, Kovess-Masfety, Viviane, Jean-Lepine, Pierre, Williams, David R., Developmental Psychology, and Scientific Visualization and Computer Graphics

Subjects
medicine.medical_specialty, Comorbid anxiety, Anxiety, Article, Odds, Stress Disorders, Post-Traumatic, Surveys and Questionnaires, Epidemiology, Health care, medicine, Humans, Child, Psychiatry, health services, Survival analysis, treatment, business.industry, PTSD, Patient Acceptance of Health Care, Health Surveys, Mental health, Psychiatry and Mental health, Clinical Psychology, Posttraumatic stress, cross national, trauma, Helpfulness, epidemiology, business
Abstract

Background: Perceived helpfulness of treatment is an important healthcare quality indicator in the era of patient-centered care. We examine probability and predictors of two key components of this indicator for posttraumatic stress disorder (PTSD). Methods: Data come from World Mental Health surveys in 16 countries. Respondents who ever sought PTSD treatment (n = 779) were asked if treatment was ever helpful and, if so, the number of professionals they had to see to obtain helpful treatment. Patients whose treatment was never helpful were asked how many professionals they saw. Parallel survival models were estimated for obtaining helpful treatment in a specific encounter and persisting in help-seeking after earlier unhelpful encounters. Results: Fifty seven percent of patients eventually received helpful treatment, but survival analysis suggests that it would have been 85.7% if all patients had persisted in help-seeking with up to six professionals after earlier unhelpful treatment. Survival analysis suggests that only 23.6% of patients would persist to that extent. Odds of ever receiving helpful treatment were positively associated with receiving treatment from a mental health professional, short delays in initiating help-seeking after onset, absence of prior comorbid anxiety disorders and childhood adversities, and initiating treatment before 2000. Some of these variables predicted helpfulness of specific treatment encounters and others predicted persistence after earlier unhelpful encounters. Conclusions: The great majority of patients with PTSD would receive treatment they considered helpful if they persisted in help-seeking after initial unhelpful encounters, but most patients whose initial treatment is unhelpful give up before receiving helpful treatment.

Published
2020

9. Alcohol Drinking and Health in Ageing : A Global Scale Analysis of Older Individual Data through the Harmonised Dataset of ATHLOS

Author

Tyrovolas, Stefanos, Panaretos, Dimitris, Daskalopoulou, Christina, Gine-Vazquez, Iago, Sanchez Niubo, Albert, Olaya, Beatriz, Bobak, Martin, Prince, Martin, Prina, Matthew, Luis Ayuso-Mateos, Jose, Felix Caballero, Francisco, Garcia-Esquinas, Esther, Holger, Arndt, Scherbov, Sergei, Sanderson, Warren, Gheno, Ilenia, Koupil, Ilona, Bickenbach, Jerome, Chatterji, Somnath, Koskinen, Seppo, Raggi, Alberto, Pajak, Andrzej, Tobiasz-Adamczyk, Beata, Maria Haro, Josep, Panagiotakos, Demosthenes, Tyrovolas, Stefanos, Panaretos, Dimitris, Daskalopoulou, Christina, Gine-Vazquez, Iago, Sanchez Niubo, Albert, Olaya, Beatriz, Bobak, Martin, Prince, Martin, Prina, Matthew, Luis Ayuso-Mateos, Jose, Felix Caballero, Francisco, Garcia-Esquinas, Esther, Holger, Arndt, Scherbov, Sergei, Sanderson, Warren, Gheno, Ilenia, Koupil, Ilona, Bickenbach, Jerome, Chatterji, Somnath, Koskinen, Seppo, Raggi, Alberto, Pajak, Andrzej, Tobiasz-Adamczyk, Beata, Maria Haro, Josep, and Panagiotakos, Demosthenes

Abstract

We investigated the relation between alcohol drinking and healthy ageing by means of a validated health status metric, using individual data from the Ageing Trajectories of Health: Longitudinal Opportunities and Synergies (ATHLOS) project. For the purposes of this study, the ATHLOS harmonised dataset, which includes information from individuals aged 65+ in 38 countries, was analysed (n = 135,440). Alcohol drinking was reflected by means of three harmonised variables: alcohol drinking frequency, current and past alcohol drinker. A set of 41 self-reported health items and measured tests were used to generate a specific health metric. In the harmonised dataset, the prevalence of current drinking was 47.5% while of past drinking was 26.5%. In the pooled sample, current alcohol drinking was positively associated with better health status among older adults ((b-coef (95% CI): 1.32(0.45 to 2.19)) and past alcohol drinking was inversely related (b-coef (95% CI): −0.83 (−1.51 to −0.16)) with health status. Often alcohol consumption appeared to be beneficial only for females in all super-regions except Africa, both age group categories (65–80 years old and 80+), both age group categories, as well as among all the financial status categories (all p < 0.05). Regional analysis pictured diverse patterns in the association for current and past alcohol drinkers. Our results report the need for specific alcohol intake recommendations among older adults that will help them maintain a better health status throughout the ageing process.

Published
2020
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12. Types of Racism and Twitter Users’ Responses Amid the COVID-19 Outbreak: Content Analysis.

Author

Lloret-Pineda, Amanda, Yuelu He, Maria Haro, Josep, and Cristóbal-Narváez, Paula

Subjects
RACISM, COVID-19 pandemic, SOCIAL media, CONTENT analysis
Abstract

Background: When the first COVID-19 cases were noticed in China, many racist comments against Chinese individuals spread. As there is a huge need to better comprehend why all of these targeted comments and opinions developed specifically at the start of the outbreak, we sought to carefully examine racism and advocacy efforts on Twitter in the first quarter of 2020 (January 15 to March 3, 2020). Objective: The first research question aimed to understand the main type of racism displayed on Twitter during the first quarter of 2020. The second research question focused on evaluating Twitter users’ positive and negative responses regarding racism toward Chinese individuals. Methods: Content analysis of tweets was utilized to address the two research questions. Using the NCapture browser link and NVivo software, tweets in English and Spanish were pulled from the Twitter data stream from January 15 to March 3, 2020. A total of 19,150 tweets were captured using the advanced Twitter search engine with the keywords and hashtags #nosoyunvirus, #imNotAVirus, #ChineseDon’tComeToJapan, #racism, “No soy un virus,” and “Racismo Coronavirus.” After cleaning the data, a total of 402 tweets were codified and analyzed. Results: The data confirmed clear sentiments of racism against Chinese individuals during the first quarter of 2020. The tweets displayed individual, cultural, and institutional racism. Individual racism was the most commonly reported form of racism, specifically displaying physical and verbal aggression. As a form of resistance, Twitter users created spaces for advocacy and activism. The hashtag “I am not a virus” helped to break stereotypes, prejudice, and discrimination on Twitter. Conclusions: Advocacy efforts were enormous both inside and outside the Chinese community; an allyship sentiment was fostered by some white users, and an identification with the oppression experienced by the Chinese population was expressed in the Black and Muslim worldwide communities. Activism through social media manifested through art, food sharing, and community support. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Blunted Autonomic Reactivity to Mental Stress in Depression Quantified by Nonlinear Cardiorespiratory Coupling Indices

Author

Kontaxis, Spyridon, primary, Laguna, Pablo, additional, García Pages, Esther, additional, Posadas-de Miguel, Mar, additional, Siddi, Sara, additional, Luisa Bernal, Maria, additional, Maria Haro, Josep, additional, Aguiló, Jordi, additional, de la Camara, Concepción, additional, Bailón, Raquel, additional, and Gil, Eduardo, additional

Published
2020
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15. Maternal mortality and morbidity burden in the Eastern Mediterranean Region : findings from the Global Burden of Disease 2015 study

Author

Mokdad, Ali H, Khalil, Ibrahim, Collison, Michael, El Bcheraoui, Charbel, Charara, Raghid, Moradi-Lakeh, Maziar, Afshin, Ashkan, Chew, Adrienne, Daoud, Farah, Krohn, Kristopher J, Colombara, Danny, Ehrenkranz, Rebecca, Kutz, Michael, Wang, Haidong, Abajobir, Amanuel Alemu, Abd-Allah, Foad, Abraha, Haftom Niguse, Abu-Raddad, Laith J, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Ahmed, Kedir Yimam, Ahmed, Muktar Beshir, Al Lami, Faris Hasan, Alam, Khurshid, Alasfoor, Deena, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Al-Maskari, Fatma, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Anber, Nahla, Ansari, Hossein, Asayesh, Hamid, Asghar, Rana Jawad, Atey, Tesfay Mehari, Ayele, Tadesse Awoke, Baernighausen, Till, Bacha, Umar, Barac, Aleksandra, Barker-Collo, Suzanne L, Baune, Bernhard T, Bazargan-Hejazi, Shahrzad, Geffen, David, Bedi, Neeraj, Bensenor, Isabela M, Berhane, Adugnaw, Beyene, Addisu Shunu, Bhutta, Zulfiqar A, Boneya, Dube Jara, Borschmann, Rohan, Breitborde, Nicholas JK, Butt, Zahid A, Catala-Lopez, Ferran, Ciobanu, Liliana G, Danawi, Hadi, Deribew, Amare, Dharmaratne, Samath D, Doyle, Kerrie E, Endries, Aman Yesuf, Faraon, Emerito Jose Aquino, Faro, Andre, Farvid, Maryam S, Fekadu, Wubalem, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Giref, Ababi Zergaw, Gishu, Melkamu Dedefo, Goulart, Alessandra Carvalho, Habtewold, Tesfa Dejenie, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Maria Haro, Josep, Hassanvand, Mohammad Sadegh, Horita, Nobuyuki, Hsairi, Mohamed, Huang, Hsiang, Husseini, Abdullatif, Jakovljevic, Mihajlo B, James, Spencer Lewis, Jonas, Jost B, Kasaeian, Amir, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khoja, Abdullah Tawfih Abdullah, Khosravi, Ardeshir, Khubchandani, Jagdish, Kim, Daniel, Kim, Yun Jin, Kokubo, Yoshihiro, Koyanagi, Ai, Defo, Barthelemy Kuate, Larson, Heidi J, Latif, Asma Abdul, Lee, Paul H, Leshargie, Cheru Tesema, Leung, Ricky, Lo, Loon-Tzian, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Martinez-Raga, Jose, Farid, Habibolah Masoudi, Mazidi, Mohsen, McGrath, John J, Memish, Ziad A, Mendoza, Walter, Mengesha, Melkamu Merid, Mengistie, Mubarek Abera, Mensah, George A, Mezgebe, Haftay Berhane, Miller, Ted R, Mitchell, Philip B, Mohammadi, Alireza, Mohammed, Shafiu, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Palomares Castillo, Elizabeth, Papachristou, Christina, Patten, Scott B, Patton, George C, Pereira, David M, Pervaiz, Aslam, Phillips, Michael Robert, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rawaf, David Laith, Rawaf, Salman, Refaat, Amany H, Rezaei, Satar, Rezai, Mohammad Sadegh, Roshandel, Gholamreza, Safdarian, Mahdi, Safiabadi, Mahdi, Safiri, Saeid, Sagar, Rajesh, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sartorius, Benn, Saylan, Mete I, Seedat, Soraya, Sepanlou, Sadaf G, Shaikh, Masood Ali, Shamsizadeh, Morteza, Santos Silva, Diego Augusto, Singh, Jasvinder A, Sobaih, Badr HA, Sreeramareddy, Chandrashekhar T, Stein, Dan J, Abdulkader, Rizwan Suliankatchi, Sykes, Bryan L, Tabares-Seisdedos, Rafael, Sufiyan, Muawiyyah, Tabb, Karen M, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Topor-Madry, Roman, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vollset, Stein Emil, Wakayo, Tolassa, Wang, Yuan-Pang, Werdecker, Andrea, Westerman, Ronny, Workicho, Abdulhalik, Yaghoubi, Mohsen, Yimam, Hassen Hamid, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Zaki, Maysaa El Sayed, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Kassebaum, Nicholas J, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, UCH. Departamento de Farmacia, Producción Científica UCH 2018, Mokdad, Ali H, Khalil, Ibrahim, Collison, Michael, El Bcheraou, Charbel, Ciobanu, Liliana G, and Murray, Christopher JL

Subjects
Adult, Burden of disease, Maternal mortality, medicine.medical_specialty, Health (social science), Psychological intervention, SAÚDE DA MULHER, Global Health, maternal health, Eastern Mediterranean Region, Global Burden of Disease, Middle East, 03 medical and health sciences, 0302 clinical medicine, Environmental health, medicine, Global health, Journal Article, Humans, 030212 general & internal medicine, 030219 obstetrics & reproductive medicine, Mediterranean Region, maternal mortality, business.industry, Public health, Age Factors, 1. No poverty, Public Health, Environmental and Occupational Health, Reproductive life, 3. Good health, Eastern mediterranean, Pregnant women - Mortality - Eastern Mediterranean, Standardized mortality ratio, 1117 Public Health And Health Services, Life expectancy, Mujeres embarazadas - Mortalidad - Mediterráneo oriental (Región), Original Article, Female, Public Health, Maternal health, Morbidity, business
Abstract

Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://link.springer.com/article/10.1007%2Fs00038-017-1004-3 Este artículo forma parte del suplemento titulado "The state of health in the Eastern Mediterranean Region, 1990-2015". Objectives Assessing the burden of maternal mortality is important for tracking progress and identifying public health gaps. This paper provides an overview of the burden of maternal mortality in the Eastern Mediterranean Region (EMR) by underlying cause and age from 1990 to 2015. Methods We used the results of the Global Burden of Disease 2015 study to explore maternal mortality in the EMR countries. Results The maternal mortality ratio in the EMR decreased 16.3% from 283 (241–328) maternal deaths per 100,000 live births in 1990 to 237 (188–293) in 2015. Maternal mortality ratio was strongly correlated with socio-demographic status, where the lowest-income countries contributed the most to the burden of maternal mortality in the region. Conclusion Progress in reducing maternal mortality in the EMR has accelerated in the past 15 years, but the burden remains high. Coordinated and rigorous efforts are needed to make sure that adequate and timely services and interventions are available for women at each stage of reproductive life.

Published
2018
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16. Adolescent health in the Eastern Mediterranean Region : findings from the global burden of disease 2015 study

Author

Mokdad, Ali H, Azzopardi, Peter, Cini, Karly, Kennedy, Elissa, Sawyer, Susan, El Bcheraoui, Charbel, Charara, Raghid, Khalil, Ibrahim, Moradi-Lakeh, Maziar, Collison, Michael, Afifi, Rima A, Al-Raiby, Jamela, Krohn, Kristopher J, Daoud, Farah, Chew, Adrienne, Afshin, Ashkan, Foreman, Kyle J, Kassebaum, Nicholas J, Kutz, Michael, Kyu, Hmwe H, Liu, Patrick, Olsen, Helen E, Smith, Alison, Stanaway, Jeffrey D, Wang, Haidong, Arnlov, Johan, Kiadaliri, Aliasghar Ahmad, Alam, Khurshid, Alasfoor, Deena, Ali, Raghib, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Anber, Nahla, Antonio, Carl Abelardo T, Anwari, Palwasha, Artaman, Al, Asayesh, Hamid, Barker-Collo, Suzanne L, Bedi, Neeraj, Beghi, Ettore, Bennett, Derrick A, Bensenor, Isabela M, Bhutta, Zulfiqar A, Butt, Zahid A, Castaneda-Orjuela, Carlos A, Catala-Lopez, Ferran, Charlson, Fiona J, Danawi, Hadi, De Leo, Diego, Degenhardt, Louisa, Denno, Donna, Deribe, Kebede, Jarlais, Don C Des, Dey, Subhojit, Dharmaratne, Samath D, Djalalinia, Shirin, Erskine, Holly E, Fereshtehnejad, Seyed-Mohammad, Ferrari, Alize J, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Geleijnse, Johanna M, Gona, Philimon N, Gugnani, Harish Chander, Gupta, Rajeev, Hamadeh, Randah Ribhi, Hamidi, Samer, Maria Haro, Josep, Hay, Roderick J, Hearps, Stephen JC, Hendrie, Delia, Hotez, Peter J, Hu, Guoqing, Jonas, Jost B, Karch, Andre, Karimi, Seyed M, Kasaeian, Amir, Kebede, Seifu, Kengne, Andre Pascal, Khan, Ejaz Ahmad, Khosravi, Ardeshir, Khubchandani, Jagdish, Kokubo, Yoshihiro, Kopec, Jacek A, Kosen, Soewarta, Larson, Heidi J, Larsson, Anders, Leasher, Janet L, Leung, Janni, Li, Yongmei, Lotufo, Paulo A, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Majdzadeh, Reza, Majeed, Azeem, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Mhimbira, Francis Apolinary, Miller, Ted R, Mitchell, Philip B, Monasta, Lorenzo, Obermeyer, Carla Makhlouf, Oh, In-Hwan, Olusanya, Bolajoko Olubukunola, Ortiz, Alberto, Park, Eun-Kee, Parry, Matti, Pereira, David M, Phillips, Michael Robert, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rana, Saleem M, Rawaf, David Laith, Rawaf, Salman, Reavley, Nicola, Renzaho, Andre MN, Rezaei, Satar, Sadegh-Rezai, Mohammad, Rios-Zertuche, Diego, Roshandel, Gholamreza, Rothenbacher, Dietrich, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sanabria, Juan Ramon, Santomauro, Damian, Sartorius, Benn, Schwebel, David C, Seedat, Soraya, Sepanlou, Sadaf G, Setegn, Tesfaye, Shaheen, Amira, Shaikh, Masood Ali, Shiri, Rahman, Sigfusdottir, Inga Dora, Singh, Jasvinder A, Sobaih, Badr HA, Sreeramareddy, Chandrashekhar T, Abdulkader, Rizwan Suliankatchi, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thomson, Alan J, Tonelli, Marcello, Topor-Madry, Roman, Tran, Bach Xuan, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Whiteford, Harvey A, Yano, Yuichiro, Yaseri, Mehdi, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Patton, George C, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany., Department of Public Health, Secure Systems research group / N. Asokan, and Clinicum

Subjects
Male, Health (social science), Nutrition and Disease, Laboratory of Virology, Poison control, Adolescent health, 030204 cardiovascular system & hematology, Global Health, Occupational safety and health, Global Burden of Disease, Disasters, 0302 clinical medicine, Risk Factors, Voeding en Ziekte, Prevalence, Global health, 030212 general & internal medicine, Child, education.field_of_study, Middle East, Mediterranean Region, Mental Disorders, Smoking, 1. No poverty, Burden of disease, Public Health, Global Health, Social Medicine and Epidemiology, MEDITERRÂNEO, 3142 Public health care science, environmental and occupational health, 3. Good health, Contraception, 1117 Public Health And Health Services, OBESITY, Original Article, Female, Public Health, medicine.medical_specialty, Adolescent, Population, OS Groenvoorziening, Developing country, Communicable Diseases, Eastern Mediterranean Region, Laboratorium voor Virologie, Young Adult, 03 medical and health sciences, FUTURE, Environmental health, SYSTEMATIC ANALYSIS, medicine, Humans, Noncommunicable Diseases, education, VLAG, Public health, Public Health, Environmental and Occupational Health, Klinisk medicin, Overweight, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, RISK-FACTORS, INJURIES, Morbidity, Clinical Medicine
Abstract

Objectives The 22 countries of the East Mediterranean Region (EMR) have large populations of adolescents aged 10–24 years. These adolescents are central to assuring the health, development, and peace of this region. We described their health needs. Methods Using data from the Global Burden of Disease Study 2015 (GBD 2015), we report the leading causes of mortality and morbidity for adolescents in the EMR from 1990 to 2015. We also report the prevalence of key health risk behaviors and determinants. Results Communicable diseases and the health consequences of natural disasters reduced substantially between 1990 and 2015. However, these gains have largely been offset by the health impacts of war and the emergence of non-communicable diseases (including mental health disorders), unintentional injury, and self-harm. Tobacco smoking and high body mass were common health risks amongst adolescents. Additionally, many EMR countries had high rates of adolescent pregnancy and unmet need for contraception. Conclusions Even with the return of peace and security, adolescents will have a persisting poor health profile that will pose a barrier to socioeconomic growth and development of the EMR. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-1003-4) contains supplementary material, which is available to authorized users.

Published
2018

17. Adolescent health in the Eastern Mediterranean Region : findings from the global burden of disease 2015 study

Author

Mokdad, Ali H., Azzopardi, Peter, Cini, Karly, Kennedy, Elissa, Sawyer, Susan, El Bcheraoui, Charbel, Charara, Raghid, Khalil, Ibrahim, Moradi-Lakeh, Maziar, Collison, Michael, Afifi, Rima A., Al-Raiby, Jamela, Krohn, Kristopher J., Daoud, Farah, Chew, Adrienne, Afshin, Ashkan, Foreman, Kyle J., Kassebaum, Nicholas J., Kutz, Michael, Kyu, Hmwe H., Liu, Patrick, Olsen, Helen E., Smith, Alison, Stanaway, Jeffrey D., Wang, Haidong, Arnlov, Johan, Kiadaliri, Aliasghar Ahmad, Alam, Khurshid, Alasfoor, Deena, Ali, Raghib, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Anber, Nahla, Antonio, Carl Abelardo T., Anwari, Palwasha, Artaman, Al, Asayesh, Hamid, Barker-Collo, Suzanne L., Bedi, Neeraj, Beghi, Ettore, Bennett, Derrick A., Bensenor, Isabela M., Bhutta, Zulfiqar A., Butt, Zahid A., Castaneda-Orjuela, Carlos A., Catala-Lopez, Ferran, Charlson, Fiona J., Danawi, Hadi, De Leo, Diego, Degenhardt, Louisa, Denno, Donna, Deribe, Kebede, Jarlais, Don C. Des, Dey, Subhojit, Dharmaratne, Samath D., Djalalinia, Shirin, Erskine, Holly E., Fereshtehnejad, Seyed-Mohammad, Ferrari, Alize J., Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Geleijnse, Johanna M., Gona, Philimon N., Gugnani, Harish Chander, Gupta, Rajeev, Hamadeh, Randah Ribhi, Hamidi, Samer, Maria Haro, Josep, Hay, Roderick J., Hearps, Stephen J. C., Hendrie, Delia, Hotez, Peter J., Hu, Guoqing, Jonas, Jost B., Karch, Andre, Karimi, Seyed M., Kasaeian, Amir, Kebede, Seifu, Kengne, Andre Pascal, Khan, Ejaz Ahmad, Khosravi, Ardeshir, Khubchandani, Jagdish, Kokubo, Yoshihiro, Kopec, Jacek A., Kosen, Soewarta, Larson, Heidi J., Larsson, Anders, Leasher, Janet L., Leung, Janni, Li, Yongmei, Lotufo, Paulo A., Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Majdzadeh, Reza, Majeed, Azeem, Memiah, Peter, Memish, Ziad A., Mendoza, Walter, Mhimbira, Francis Apolinary, Miller, Ted R., Mitchell, Philip B., Monasta, Lorenzo, Obermeyer, Carla Makhlouf, Oh, In-Hwan, Olusanya, Bolajoko Olubukunola, Ortiz, Alberto, Park, Eun-Kee, Parry, Matti, Pereira, David M., Phillips, Michael Robert, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rana, Saleem M., Rawaf, David Laith, Rawaf, Salman, Reavley, Nicola, Renzaho, Andre M. N., Rezaei, Satar, Sadegh-Rezai, Mohammad, Rios-Zertuche, Diego, Roshandel, Gholamreza, Rothenbacher, Dietrich, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M., Sanabria, Juan Ramon, Santomauro, Damian, Sartorius, Benn, Schwebel, David C., Seedat, Soraya, Sepanlou, Sadaf G., Setegn, Tesfaye, Shaheen, Amira, Shaikh, Masood Ali, Shiri, Rahman, Sigfusdottir, Inga Dora, Singh, Jasvinder A., Sobaih, Badr H. A., Sreeramareddy, Chandrashekhar T., Abdulkader, Rizwan Suliankatchi, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thomson, Alan J., Tonelli, Marcello, Topor-Madry, Roman, Tran, Bach Xuan, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A., Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Whiteford, Harvey A., Yano, Yuichiro, Yaseri, Mehdi, Yonemoto, Naohiro, Younis, Mustafa Z., Yu, Chuanhua, Jumaan, Aisha O., Vos, Theo, Hay, Simon I., Naghavi, Mohsen, Patton, George C., Murray, Christopher J. L., Mokdad, Ali H., Azzopardi, Peter, Cini, Karly, Kennedy, Elissa, Sawyer, Susan, El Bcheraoui, Charbel, Charara, Raghid, Khalil, Ibrahim, Moradi-Lakeh, Maziar, Collison, Michael, Afifi, Rima A., Al-Raiby, Jamela, Krohn, Kristopher J., Daoud, Farah, Chew, Adrienne, Afshin, Ashkan, Foreman, Kyle J., Kassebaum, Nicholas J., Kutz, Michael, Kyu, Hmwe H., Liu, Patrick, Olsen, Helen E., Smith, Alison, Stanaway, Jeffrey D., Wang, Haidong, Arnlov, Johan, Kiadaliri, Aliasghar Ahmad, Alam, Khurshid, Alasfoor, Deena, Ali, Raghib, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Anber, Nahla, Antonio, Carl Abelardo T., Anwari, Palwasha, Artaman, Al, Asayesh, Hamid, Barker-Collo, Suzanne L., Bedi, Neeraj, Beghi, Ettore, Bennett, Derrick A., Bensenor, Isabela M., Bhutta, Zulfiqar A., Butt, Zahid A., Castaneda-Orjuela, Carlos A., Catala-Lopez, Ferran, Charlson, Fiona J., Danawi, Hadi, De Leo, Diego, Degenhardt, Louisa, Denno, Donna, Deribe, Kebede, Jarlais, Don C. 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A., Sreeramareddy, Chandrashekhar T., Abdulkader, Rizwan Suliankatchi, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thomson, Alan J., Tonelli, Marcello, Topor-Madry, Roman, Tran, Bach Xuan, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A., Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Whiteford, Harvey A., Yano, Yuichiro, Yaseri, Mehdi, Yonemoto, Naohiro, Younis, Mustafa Z., Yu, Chuanhua, Jumaan, Aisha O., Vos, Theo, Hay, Simon I., Naghavi, Mohsen, Patton, George C., and Murray, Christopher J. L.

Abstract

The 22 countries of the East Mediterranean Region (EMR) have large populations of adolescents aged 10-24 years. These adolescents are central to assuring the health, development, and peace of this region. We described their health needs. Using data from the Global Burden of Disease Study 2015 (GBD 2015), we report the leading causes of mortality and morbidity for adolescents in the EMR from 1990 to 2015. We also report the prevalence of key health risk behaviors and determinants. Communicable diseases and the health consequences of natural disasters reduced substantially between 1990 and 2015. However, these gains have largely been offset by the health impacts of war and the emergence of non-communicable diseases (including mental health disorders), unintentional injury, and self-harm. Tobacco smoking and high body mass were common health risks amongst adolescents. Additionally, many EMR countries had high rates of adolescent pregnancy and unmet need for contraception. Even with the return of peace and security, adolescents will have a persisting poor health profile that will pose a barrier to socioeconomic growth and development of the EMR.

Published
2018
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18. Alcohol use and burden for 195 countries and territories, 1990-2016 : a systematic analysis for the Global Burden of Disease Study 2016

Author

Griswold, Max G., Fullman, Nancy, Hawley, Caitlin, Arian, Nicholas, Zimsen, Stephanie R. M., Tymeson, Hayley D., Venkateswaran, Vidhya, Tapp, Austin Douglas, Forouzanfar, Mohammad H., Salama, Joseph S., Abate, Kalkidan Hassen, Abate, Degu, Abay, Solomon M., Abbafati, Cristiana, Abdulkader, Rizwan Suliankatchi, Abebe, Zegeye, Aboyans, Victor, Abrar, Mohammed Mehdi, Acharya, Pawan, Adetokunboh, Olatunji O., Adhikari, Tara Ballav, Adsuar, Jose C., Afarideh, Mohsen, Agardh, Emilie Elisabet, Agarwal, Gina, Aghayan, Sargis Aghasi, Agrawal, Sutapa, Ahmed, Muktar Beshir, Akibu, Mohammed, Akinyemiju, Tomi, Akseer, Nadia, Al Asfoor, Deena H., Al-Aly, Ziyad, Alahdab, Fares, Alam, Khurshid, Albujeer, Ammar, Alene, Kefyalew Addis, Ali, Raghib, Ali, Syed Danish, Alijanzadeh, Mehran, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Allebeck, Peter, Alvis-Guzman, Nelson, Amare, Azmeraw T., Aminde, Leopold N., Ammar, Walid, Amoako, Yaw Ampem, Amul, Gianna Gayle Herrera, Andrei, Catalina Liliana, Angus, Colin, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T., Aremu, Olatunde, Arnlov, Johan, Artaman, Al, Aryal, Krishna K., Assadi, Reza, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide F. G. A., Awasthi, Ashish, Ayele, Henok Tadesse, Ayer, Rakesh, Ayuk, Tambe B., Azzopardi, Peter S., Badali, Hamid, Badawi, Alaa, Banach, Maciej, Barker-Collo, Suzanne Lyn, Barrero, Lope H., Basaleem, Huda, Baye, Estifanos, Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Bejot, Yannick, Belachew, Abate Bekele, Belay, Saba Abraham, Bennett, Derrick A., Bensenor, Isabela M., Bernabe, Eduardo, Bernstein, Robert S., Beyene, Addisu Shunu, Beyranvand, Tina, Bhaumik, Soumyadeeep, Bhutta, Zulfiqar A., Biadgo, Belete, Bijani, Ali, Bililign, Nigus, Birlik, Sait Mentes, Birungi, Charles, Bizuneh, Hailemichael, Bjerregaard, Peter, Bjorge, Tone, Borges, Guilherme, Bosetti, Cristina, Boufous, Soufiane, Bragazzi, Nicola Luigi, Brenner, Hermann, Butt, Zahid A., Cahuana-Hurtado, Lucero, Calabria, Bianca, Campos-Nonato, Ismael R., Campuzano Rincon, Julio Cesar, Carreras, Giulia, Carrero, Juan J., Carvalho, Felix, Castaneda-Orjuela, Carlos A., Castillo Rivas, Jacqueline, Catala-Lopez, Ferran, Chang, Jung-Chen, Charlson, Fiona J., Chattopadhyay, Aparajita, Chaturvedi, Pankaj, Chowdhury, Rajiv, Christopher, Devasahayam J., Chung, Sheng-Chia, Ciobanu, Liliana G., Claro, Rafael M., Conti, Sara, Cousin, Ewerton, Criqui, Michael H., Dachew, Berihun Assefa, Dargan, Paul, I, Daryani, Ahmad, Das Neves, Jose, Davletov, Kairat, De Castro, Filipa, De Courten, Barbora, De Neve, Jan-Walter, Degenhardt, Louisa, Demoz, Gebre Teklemariam, Des Jarlais, Don C., Dey, Subhojit, Dhaliwal, Rupinder Singh, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Doku, David Teye, Doyle, Kerrie E., Dubey, Manisha, Dubljanin, Eleonora, Duncan, Bruce B., Ebrahimi, Hedyeh, Edessa, Dumessa, Zaki, Maysaa El Sayed, Ermakov, Sergei Petrovich, Erskine, Holly E., Esteghamati, Alireza, Faramarzi, Mahbobeh, Farioli, Andrea, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Felisbino-Mendes, Mariana Santos, Fernandes, Eduarda, Ferrari, Alize J., Ferri, Cleusa P., Fijabi, Daniel Obadare, Filip, Irina, Finger, Jonas David, Fischer, Florian, Flaxman, Abraham D., Franklin, Richard Charles, Futran, Neal D., Gallus, Silvano, Ganji, Morsaleh, Gankpe, Fortune Gbetoho, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Geleijnse, Johanna M., Ghadimi, Reza, Ghandour, Lilian A., Ghimire, Mamata, Gill, Paramjit Singh, Ginawi, Ibrahim Abdelmageed, Giref, Ababi Zergaw Z., Gona, Philimon N., Gopalani, Sameer Vali, Gotay, Carolyn C., Goulart, Alessandra C., Greaves, Felix, Grosso, Giuseppe, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Alma Gutierrez, Reyna, Gvs, Murthy, Hafezi-Nejad, Nima, Hagos, Tekleberhan Beyene, Hailu, Gessessew Bugssa, Hamadeh, Randah R., Hamidi, Samer, Hankey, Graeme J., Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hay, Simon, I, Heibati, Behzad, Henok, Andualem, Heredia-Pi, Ileana, Francisco Hernandez-Llanes, Norberto, Herteliu, Claudiu, Hibstu, Desalegn Ts Tsegaw, Hoogar, Praveen, Horita, Nobuyuki, Hosgood, H. 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A., Awasthi, Ashish, Ayele, Henok Tadesse, Ayer, Rakesh, Ayuk, Tambe B., Azzopardi, Peter S., Badali, Hamid, Badawi, Alaa, Banach, Maciej, Barker-Collo, Suzanne Lyn, Barrero, Lope H., Basaleem, Huda, Baye, Estifanos, Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Bejot, Yannick, Belachew, Abate Bekele, Belay, Saba Abraham, Bennett, Derrick A., Bensenor, Isabela M., Bernabe, Eduardo, Bernstein, Robert S., Beyene, Addisu Shunu, Beyranvand, Tina, Bhaumik, Soumyadeeep, Bhutta, Zulfiqar A., Biadgo, Belete, Bijani, Ali, Bililign, Nigus, Birlik, Sait Mentes, Birungi, Charles, Bizuneh, Hailemichael, Bjerregaard, Peter, Bjorge, Tone, Borges, Guilherme, Bosetti, Cristina, Boufous, Soufiane, Bragazzi, Nicola Luigi, Brenner, Hermann, Butt, Zahid A., Cahuana-Hurtado, Lucero, Calabria, Bianca, Campos-Nonato, Ismael R., Campuzano Rincon, Julio Cesar, Carreras, Giulia, Carrero, Juan J., Carvalho, Felix, Castaneda-Orjuela, Carlos A., Castillo Rivas, Jacqueline, Catala-Lopez, Ferran, Chang, Jung-Chen, Charlson, Fiona J., Chattopadhyay, Aparajita, Chaturvedi, Pankaj, Chowdhury, Rajiv, Christopher, Devasahayam J., Chung, Sheng-Chia, Ciobanu, Liliana G., Claro, Rafael M., Conti, Sara, Cousin, Ewerton, Criqui, Michael H., Dachew, Berihun Assefa, Dargan, Paul, I, Daryani, Ahmad, Das Neves, Jose, Davletov, Kairat, De Castro, Filipa, De Courten, Barbora, De Neve, Jan-Walter, Degenhardt, Louisa, Demoz, Gebre Teklemariam, Des Jarlais, Don C., Dey, Subhojit, Dhaliwal, Rupinder Singh, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Doku, David Teye, Doyle, Kerrie E., Dubey, Manisha, Dubljanin, Eleonora, Duncan, Bruce B., Ebrahimi, Hedyeh, Edessa, Dumessa, Zaki, Maysaa El Sayed, Ermakov, Sergei Petrovich, Erskine, Holly E., Esteghamati, Alireza, Faramarzi, Mahbobeh, Farioli, Andrea, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Felisbino-Mendes, Mariana Santos, Fernandes, Eduarda, Ferrari, Alize J., Ferri, Cleusa P., Fijabi, Daniel Obadare, Filip, Irina, Finger, Jonas David, Fischer, Florian, Flaxman, Abraham D., Franklin, Richard Charles, Futran, Neal D., Gallus, Silvano, Ganji, Morsaleh, Gankpe, Fortune Gbetoho, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Geleijnse, Johanna M., Ghadimi, Reza, Ghandour, Lilian A., Ghimire, Mamata, Gill, Paramjit Singh, Ginawi, Ibrahim Abdelmageed, Giref, Ababi Zergaw Z., Gona, Philimon N., Gopalani, Sameer Vali, Gotay, Carolyn C., Goulart, Alessandra C., Greaves, Felix, Grosso, Giuseppe, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Alma Gutierrez, Reyna, Gvs, Murthy, Hafezi-Nejad, Nima, Hagos, Tekleberhan Beyene, Hailu, Gessessew Bugssa, Hamadeh, Randah R., Hamidi, Samer, Hankey, Graeme J., Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hay, Simon, I, Heibati, Behzad, Henok, Andualem, Heredia-Pi, Ileana, Francisco Hernandez-Llanes, Norberto, Herteliu, Claudiu, Hibstu, Desalegn Ts Tsegaw, Hoogar, Praveen, Horita, Nobuyuki, Hosgood, H. Dean, Hosseini, Mostafa, Hostiuc, Mihaela, Hu, Guoqing, Huang, Hsiang, Husseini, Abdullatif, Idrisov, Bulat, Ileanu, Bogdan Vasile, Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Jackson, Maria D., Jakovljevic, Mihajlo, Jayatilleke, Achala Upendra, Jha, Ravi Prakash, Jonas, Jost B., Jozwiak, Jacek Jerzy, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kapil, Umesh, Kasaeian, Amir, Kassa, Tesfaye D. Dessale, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Kebede, Seifu, Kefale, Adane Teshome, Keiyoro, Peter Njenga, Kengne, Andre Pascal, Khader, Yousef, Khafaie, Morteza Abdullatif, Khalil, Ibrahim A., Khan, Md Nuruzzaman, Khang, Young-Ho, Khater, Mona M., Khubchandani, Jagdish, Kim, Cho-Il, Kim, Daniel, Kim, Yun Jin, Kimokoti, Ruth W., Kisa, Adnan, Kivimaki, Mika, Kochhar, Sonali, Kosen, Soewarta, Koul, Parvaiz A., Koyanagi, Ai, Krishan, Kewal, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kulkarni, Veena S., Kumar, Pushpendra, Lafranconi, Alessandra, Balaji, Arjun Lakshmana, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lami, Faris Hasan, Lan, Qing, Lang, Justin J., Lansky, Sonia, Larsson, Anders O., Latifi, Arman, Leasher, Janet L., Lee, Paul H., Leigh, James, Leinsalu, Mall, Leung, Janni, Levi, Miriam, Li, Yichong, Lim, Lee-Ling, Linn, Shai, Liu, Shiwei, Lobato-Cordero, Andrea, Lotufo, Paulo A., King Macarayan, Erlyn Rachelle, Machado, Isis Eloah, Madotto, Fabiana, Abd El Razek, Hassan Magdy, Abd El Razek, Muhammed Magdy, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Mapoma, Chabila Christopher, Martinez-Raga, Jose, Maulik, Pallab K., Mazidi, Mohsen, Mckee, Martin, Mehta, Varshil, Meier, Toni, Mekonen, Tesfa, Meles, Kidanu Gebremariam, Melese, Addisu, Memiah, Peter T. N., Mendoza, Walter, Mengistu, Desalegn Tadese, Mensah, George A., Meretoja, Tuomo J., Mezgebe, Haftay Berhane, Miazgowski, Tomasz, Miller, Ted R., Mini, G. K., Mirica, Andreea, Mirrakhimov, Erkin M., Moazen, Babak, Mohammad, Karzan Abdulmuhsin, Mohammadifard, Noushin, Mohammed, Shafiu, Monasta, Lorenzo, Moraga, Paula, Morawska, Lidia, Jalu, Moti Tolera, Mousavi, Seyyed Meysam, Mukhopadhyay, Satinath, Musa, Kamarul Imran, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Nayak, Mudavath Siva Durga Prasad, Nejjari, Chakib, Neupane, Subas, Neupane, Sudan Prasad, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Long Hoang, Nguyen, Trang Huyen, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Noubiap, Jean Jacques, Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olagunju, Andrew T., Olivares, Pedro R., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oommen, Anu Mary, Oren, Eyal, Orpana, Heather M., Ortega-Altamirano, Doris D., V, Ortiz, Justin R., Ota, Erika, Owolabi, Mayowa Ojo, Oyekale, Abayomi Samuel, Mahesh, P. A., Pana, Adrian, Park, Eun-Kee, Parry, Charles D. H., Parsian, Hadi, Patle, Ajay, Patton, George C., Paudel, Deepak, Petzold, Max, Phillips, Michael R., Pillay, Julian David, Postma, Maarten J., Pourmalek, Farshad, Prabhakaran, Dorairaj, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Afarin, Rahman, Mahfuzar, Rahman, Muhammad Aziz, Rai, Rajesh Kumar, Rajsic, Sasa, Raju, Sree Bhushan, Ram, Usha, Rana, Saleem M., Ranabhat, Chhabi Lal, Rawaf, David Laith, Rawaf, Salman, Reiner, Robert C., Reis, Cesar, Renzaho, Andre M. N., Rezai, Mohammad Sadegh, Roever, Leonardo, Ronfani, Luca, Room, Robin, Roshandel, Gholamreza, Rostami, Ali, Roth, Gregory A., Roy, Ambuj, Sabde, Yogesh Damodar, Saddik, Basema, Safiri, Saeid, Sahebkar, Amirhossein, Saleem, Zikria, Salomon, Joshua A., Salvi, Sundeep Santosh, Sanabria, Juan, Dolores Sanchez-Nino, Maria, Santomauro, Damian Francesco, Santos, Itamar S., Milicevic, Milena M. M. Santric, Sarker, Abdur Razzaque, Sarmiento-Suarez, Rodrigo, Sarrafzadegan, Nizal, Sartorius, Benn, Satpathy, Maheswar, Sawhney, Monika, Saxena, Sonia, Saylan, Mete, Schaub, Michael P., Schmidt, Maria Ines, Schneider, Ione J. C., Schoettker, Ben, Schutte, Aletta Elisabeth, Schwendicke, Falk, Sepanlou, Sadaf G., Shaikh, Masood A. Ali, Sharif, Mehdi, She, Jun, Sheikh, Aziz, Shen, Jiabin, Shiferaw, Mekonnen Sisay, Shigematsu, Mika, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shukla, Sharvari Rahul, Sigfusdottir, Inga Dora, Santos Silva, Diego Augusto, Da Silva, Natacha Torres, Alves Silveira, Dayane Gabriele, Sinha, Dhirendra Narain Narain, Sitas, Freddy, Soares Filho, Adauto Martins, Soofi, Moslem, Sorensen, Reed J. D., Soriano, Joan B., Sreeramareddy, Chandrashekhar T., Steckling, Nadine, Stein, Dan J., Sufiyan, Mu'awiyyah Babale, Sur, Patrick J., Sykes, Bryan L., Tabares-Seisdedos, Rafael, Tabuchi, Takahiro, Tavakkoli, Mohammad, Tehrani-Banihashemi, Arash, Tekle, Merhawi Gebremedhin, Thapa, Subash, Thomas, Nihal, Topor-Madry, Roman, Topouzis, Fotis, Tran, Bach Xuan, Troeger, Christopher E., Truelsen, Thomas Clement, Tsilimparis, Nikolaos, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Ullah, Irfan, Uthman, Olalekan A., Valdez, Pascual R., Van Boven, Job F. M., Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Violante, Francesco S., Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Wagnew, Fasil Wagnew Shiferaw, Waheed, Yasir, Wang, Yuan-Pang, Weiderpass, Elisabete, Weldegebreal, Fitsum, Weldegwergs, Kidu Gidey, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A., Widecka, Justyna, Wijeratne, Tissa, Wyper, Grant M. A., Xu, Gelin, Yamada, Tomohide, Yano, Yuichiro, Ye, Pengpeng, Yimer, Ebrahim M., Yip, Paul, Yirsaw, Biruck Desalegn, Yisma, Engida, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z., Zachariah, Geevar, Zaidi, Zoubida, Zamani, Mohammad, Zhang, Xueying, Zodpey, Sanjay, Mokdad, Ali H., Naghavi, Mohsen, Murray, Christopher J. L., and Gakidou, Emmanuela

Abstract

Background: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older. Methods: Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health. Findings: Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2.2% (95% uncertainty interval [UI] 1.5-3.0) of age-standardised female deaths and 6.8% (5.8-8.0) of age-standardised male deaths. Among the population aged 15-49 years, alcohol use was the leading risk factor globally in 2016, with 3.8% (95% UI 3.2-4-3) of female deaths and 12.2% (10.8-13-6) of male deaths attributable to alcohol use. For the population aged 15-49 years, female attributable DALYs were 2.3% (95% UI 2.0-2.6) and male attribut, Funding: Bill & Melinda Gates Foundation

Published
2018
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19. an analysis of data from the World Mental Health Surveys

Author

Degenhardt, Louisa, Glantz, Meyer D., Evans-Lacko, Sara, Sadikova, Ekaterina, Sampson, Nancy, Thornicroft, Graham, Aguilar-Gaxiola, Sergio, Al-Hamzawi, Ali, Alonso, Jordi, Helena Andrade, Laura, Bruffaerts, Ronny, Bunting, Brendan, Bromet, Evelyn J., de Girolamo, Giovanni, Florescu, Silvia, Gureje, Oye, Maria Haro, Josep, Huang, Yueqin, Karam, Aimee Nasser, Karam, Elie G., Kiejna, Andrzej, Lee, Sing, Lepine, Jean Pierre, Levinson, Daphna, Elena Medina-Mora, Maria, Nakamura, Yosikazu, Navarro-Mateu, Fernando, Pennell, Beth Ellen, Posada-Villa, José, Scott, Kate M., Stein, Dan J., ten Have, Margreet, Torres, Yolanda, Zarkov, Zahari, Chatterji, Somnath, Kessler, Ronald C., Adamowski, Tomasz, Al-Kaisy, Mohammad, Altwaijri, Yasmin, Andrade, Laura Helena, Atwoli, Lukoye, Auerbach, Randy P., Axinn, William G., Benjet, Corina, Borges, Guilherme, Caldas-de-Almeida, José M, Cardoso, Graça, on behalf of the World Health Organization's World Mental Health Surveys collaborators, Centro de Estudos de Doenças Crónicas (CEDOC), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Psychiatry and Mental health, treatment coverage, SDG 3 - Good Health and Well-being, alcohol, Phychiatric Mental Health, United Nations Sustainable Development Goals, World Health Organization, drugs, Substance use disorders
Abstract

Funding: The authors are grateful to M. Kumvaj for her assistance with the systematic literature search. They also thank the staff of the WMHS Data Collection and Data Analysis Coordination Centres for assistance with instrumentation, fieldwork and consultation on data analysis. The WHO’s WMHS are supported by the US National Institute of Mental Health (R01 MH070884), the MacArthur Foundation, the Pfizer Foundation, the US Public Health Service (R13-MH066849, R01-MH069864 and R01 DA016558), the Fogarty International Center (R03-TW006481), the Pan American Health Organization, Eli Lilly and Company, Ortho-McNeil Pharmaceutical Inc., GlaxoSmithKline, Bristol-Myers Squibb, and Shire. The views expressed in this report are those of the authors and should not be construed to represent the views or policies of the WHO, other sponsoring organizations, agencies, or governments. This work was supported by an Australian National Health and Medical Research Council (NHMRC) project grant (no. 1081984). L. Degenhardt is supported by an NHMRC Principal Research Fellowship (no. 1041472). Substance use is a major cause of disability globally. This has been recognized in the recent United Nations Sustainable Development Goals (SDGs), in which treatment coverage for substance use disorders is identified as one of the indicators. There have been no estimates of this treatment coverage cross-nationally, making it difficult to know what is the baseline for that SDG target. Here we report data from the World Health Organization (WHO)'s World Mental Health Surveys (WMHS), based on representative community household surveys in 26 countries. We assessed the 12-month prevalence of substance use disorders (alcohol or drug abuse/dependence); the proportion of people with these disorders who were aware that they needed treatment and who wished to receive care; the proportion of those seeking care who received it; and the proportion of such treatment that met minimal standards for treatment quality (“minimally adequate treatment”). Among the 70,880 participants, 2.6% met 12-month criteria for substance use disorders; the prevalence was higher in upper-middle income (3.3%) than in high-income (2.6%) and low/lower-middle income (2.0%) countries. Overall, 39.1% of those with 12-month substance use disorders recognized a treatment need; this recognition was more common in high-income (43.1%) than in upper-middle (35.6%) and low/lower-middle income (31.5%) countries. Among those who recognized treatment need, 61.3% made at least one visit to a service provider, and 29.5% of the latter received minimally adequate treatment exposure (35.3% in high, 20.3% in upper-middle, and 8.6% in low/lower-middle income countries). Overall, only 7.1% of those with past-year substance use disorders received minimally adequate treatment: 10.3% in high income, 4.3% in upper-middle income and 1.0% in low/lower-middle income countries. These data suggest that only a small minority of people with substance use disorders receive even minimally adequate treatment. At least three barriers are involved: awareness/perceived treatment need, accessing treatment once a need is recognized, and compliance (on the part of both provider and client) to obtain adequate treatment. Various factors are likely to be involved in each of these three barriers, all of which need to be addressed to improve treatment coverage of substance use disorders. These data provide a baseline for the global monitoring of progress of treatment coverage for these disorders as an indicator within the SDGs. publishersversion published

Published
2017

20. Estimating treatment coverage for people with substance use disorders: an analysis of data from the World Mental Health Surveys

Author

Degenhardt, Louisa, Glantz, Meyer, Evans-Lacko, Sara, Sadikova, Ekaterina, Sampson, Nancy, Thornicroft, Graham, Aguilar-Gaxiola, Sergio, Al-Hamzawi, Ali, Alonso, Jordi, Helena Andrade, Laura, Bruffaerts, Ronny, Bunting, Brendan, Bromet, Evelyn J., Caldas de Almeida, José Miguel, de Girolamo, Giovanni, Florescu, Silvia, Gureje, Oye, Maria Haro, Josep, Huang, Yueqin, Karam, Aimee, Karam, Elie G., Kiejna, Andrzej, Lee, Sing, Lepine, Jean Pierre, Levinson, Daphna, Elena Medina-Mora, Maria, Nakamura, Yosikazu, Navarro-Mateu, Fernando, Pennell, Beth Ellen, Posada-Villa, José, Scott, Kate, Stein, Dan J., ten Have, Margreet, Torres, Yolanda, Zarkov, Zahari, Chatterji, Somnath, Kessler, Ronald C., Adamowski, Tomasz, Al-Kaisy, Mohammad, Altwaijri, Yasmin, Atwoli, Lukoye, Auerbach, Randy P., Axinn, William G., Benjet, Corina, Borges, Guilherme, Cardoso, Graça, Chardoul, Stephanie, de Jonge, Peter, Ormel, Johan, Williams, David R., Developmental Psychology, and Scientific Visualization and Computer Graphics

Subjects
medicine.medical_specialty, World Health Organization, World health, drugs, INJECTING DRUG-USERS, 03 medical and health sciences, 0302 clinical medicine, Treatment quality, DEPENDENCE, Environmental health, medicine, 030212 general & internal medicine, Psychiatry, VERSION, Substance use disorders, BARRIERS, business.industry, alcohol, Middle income countries, ALCOHOL-USE DISORDERS, Research Reports, CARE, SERVICES, Service provider, medicine.disease, Mental health, CANNABIS USE, 030227 psychiatry, Substance abuse, Psychiatry and Mental health, treatment coverage, ONSET, Pshychiatric Mental Health, Substance use, business, United Nations Sustainable Development Goals, Treatment need
Abstract

Substance use is a major cause of disability globally. This has been recognized in the recent United Nations Sustainable Development Goals (SDGs), in which treatment coverage for substance use disorders is identified as one of the indicators. There have been no estimates of this treatment coverage cross-nationally, making it difficult to know what is the baseline for that SDG target. Here we report data from the World Health Organization (WHO)'s World Mental Health Surveys (WMHS), based on representative community household surveys in 26 countries. We assessed the 12-month prevalence of substance use disorders (alcohol or drug abuse/dependence); the proportion of people with these disorders who were aware that they needed treatment and who wished to receive care; the proportion of those seeking care who received it; and the proportion of such treatment that met minimal standards for treatment quality ("minimally adequate treatment"). Among the 70,880 participants, 2.6% met 12-month criteria for substance use disorders; the prevalence was higher in upper-middle income (3.3%) than in high-income (2.6%) and low/lower-middle income (2.0%) countries. Overall, 39.1% of those with 12-month substance use disorders recognized a treatment need; this recognition was more common in high-income (43.1%) than in upper-middle (35.6%) and low/lower-middle income (31.5%) countries. Among those who recognized treatment need, 61.3% made at least one visit to a service provider, and 29.5% of the latter received minimally adequate treatment exposure (35.3% in high, 20.3% in upper-middle, and 8.6% in low/lower-middle income countries). Overall, only 7.1% of those with past-year substance use disorders received minimally adequate treatment: 10.3% in high income, 4.3% in upper-middle income and 1.0% in low/lower-middle income countries. These data suggest that only a small minority of people with substance use disorders receive even minimally adequate treatment. At least three barriers are involved: awareness/perceived treatment need, accessing treatment once a need is recognized, and compliance (on the part of both provider and client) to obtain adequate treatment. Various factors are likely to be involved in each of these three barriers, all of which need to be addressed to improve treatment coverage of substance use disorders. These data provide a baseline for the global monitoring of progress of treatment coverage for these disorders as an indicator within the SDGs.

Published
2017
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22. What Drives Country Differences in Cost of Alzheimer's Disease? : An Explanation from Resource Use in the GERAS Study

Author

Reed, Catherine, Happich, Michael, Maria Argimon, Josep, Maria Haro, Josep, Wimo, Anders, Bruno, Giuseppe, Dodel, Richard, Jones, Roy W., Vellas, Bruno, Belger, Mark, Reed, Catherine, Happich, Michael, Maria Argimon, Josep, Maria Haro, Josep, Wimo, Anders, Bruno, Giuseppe, Dodel, Richard, Jones, Roy W., Vellas, Bruno, and Belger, Mark

Abstract

Background: Country differences in resource use and costs of Alzheimer's disease (AD) may be driven by differences in health care systems and resource availability. Objective: To compare country resource utilization drivers of societal costs for AD dementia over 18 months. Methods: GERAS is an observational study in France (n = 419), Germany (n = 550), and the UK (n = 526). Resource use of AD patients and caregivers contributing to >1% of total societal costs (year 2010) was assessed for country differences, adjusting for participant characteristics. Results: Mean 18-month societal costs per patient were France (sic)33,339, Germany (sic)38,197, and UK (sic)37,899 (32,501) pound. Caregiver time spent on basic and instrumental activities of daily living (ADL) contributed the most to societal costs (54% France, 64% Germany, 65% UK). Caregivers in France spent less time on ADL than UK caregivers and missed fewer work days than in other countries. Compared with other countries, patients in France used more community care services overall and were more likely to use home aid. Patients in Germany were least likely to use temporary accommodation or to be institutionalized at 18 months. UK caregivers spent the most time on instrumental ADL, UK patients used fewest outpatient resources, and UK patients/caregivers were most likely to receive financial support. Conclusion: Caregiver time on ADL contributed the most to societal costs and differed across countries, possibly due to use of community care services and institutionalization. Other resources had different patterns of use across countries, reflecting country-specific health and social care systems.

Published
2017
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23. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015 : a systematic analysis for the Global Burden of Disease Study 2015

Author

Vos, Theo, Allen, Christine, Arora, Megha, Barber, Ryan M., Bhutta, Zulfiqar A., Brown, Alexandria, Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Z., Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J., Dilegge, Tina, Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Tom, Forouzanfar, Mohammad H., Fullman, Nancy, Gething, Peter W., Goldberg, Ellen M., Graetz, Nicholas, Haagsma, Juanita A., Johnson, Catherine O., Kassebaum, Nicholas J., Kawashima, Toana, Kemmer, Laura, Khalil, Ibrahim A., Kinfu, Yohannes, Kyu, Hmwe H., Leung, Janni, Liang, Xiaofeng, Lim, Stephen S., Lopez, Alan D., Lozano, Rafael, Marczak, Laurie, Mensah, George A., Mokdad, Ali H., Naghavi, Mohsen, Nguyen, Grant, Nsoesie, Elaine, Olsen, Helen, Pigott, David M., Pinho, Christine, Rankin, Zane, Reinig, Nikolas, Salomon, Joshua A., Sandar, Logan, Smith, Alison, Stanaway, Jeffrey, Steiner, Caitlyn, Teeple, Stephanie, Thomas, Bernadette A., Troeger, Christopher, Wagner, Joseph A., Wang, Haidong, Wanga, Valentine, Whiteford, Harvey A., Zoeckler, Leo, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abraham, Biju, Abubakar, Ibrahim, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M. E., Ackerman, Ilana N., Adebiyi, Akindele Olupelumi, Ademi, Zanfina, Adou, Arsene Kouablan, Afanvi, Kossivi Agbelenko, Agardh, Emilie Elisabet, Agarwal, Arnav, Kiadaliri, Aliasghar Ahmad, Ahmadieh, Hamid, Ajala, Oluremi N., Akinyemi, Rufus Olusola, Akseer, Nadia, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K. M., Aldhahri, Saleh Fahed, Alegretti, Miguel Angel, Alemu, Zewdie Aderaw, Alexander, Lily T., Alhabib, Samia, Ali, Raghib, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Amberbir, Alemayehu, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H., Anderson, Gregory M., Anderson, Benjamin, Antonio, Carl Abelardo T., Aregay, Atsede Fantahun, Ärnlöv, Johan, Artaman, Al, Asayesh, Hamid, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Banerjee, Amitava, Barac, Aleksandra, Barker-Collo, Suzanne L., Barnighausen, Till, Barregard, Lars, Barrero, Lope H., Basu, Arindam, Bazargan-Hejazi, Shahrzad, Bell, Brent, Bell, Michelle L., Bennett, Derrick A., Bensenor, Isabela M., Benzian, Habib, Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhatt, Samir, Biadgilign, Sibhatu, Bienhofff, Kelly, Bikbov, Boris, Biryukov, Stan, Bisanzio, Donal, Bjertness, Espen, Blore, Jed, Borschmann, Rohan, Boufous, Soufiane, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J. 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A., Foreman, Kyle, Fowkes, Gerry R., Fox, Jordan, Franklin, Richard C., Friedman, Joseph, Frostad, Joseph, Furst, Thomas, Futran, Neal D., Gabbe, Belinda, Ganguly, Parthasarathi, Gankpe, Fortune Gbetoho, Gebre, Teshome, Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Geleijnse, Johanna M., Gessner, Bradford D., Gibney, Katherine B., Ginawi, Ibrahim Abdelmageem Mohamed, Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Glaser, Elizabeth, Godwin, William W., Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Grainger, Rebecca, Greaves, Felix, Guillemin, Francis, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Gutierrez, Reyna A., Haile, Demewoz, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Halasa, Yara A., Hamadeh, Randah Ribhi, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Havmoeller, Rasmus, Hay, Roderick J., Beatriz Heredia-Pi, Ileana, Heydarpour, Pouria, Hoek, Hans W., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hoy, Damian G., Htet, Aung Soe, Huang, Hsiang, Huang, John J., Huynh, Chantal, Iannarone, Marissa, Iburg, Kim Moesgaard, Innos, Kaire, Inoue, Manami, Iyer, Veena J., Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jensen, Paul N., Jiang, Ying, Jibat, Tariku, Jimenez-Corona, Aida, Jin, Ye, Jonas, Jost B., Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, Andre, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khaiff, Abdur Rahman, Khaiff, Ejaz Ahmad, Khang, Young-Ho, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Pauline, Kim, Cho-il, Kim, Daniel, Kim, Yun Jin, Kissoon, Niranjan, Knibbs, Luke D., Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kolte, Dhaval, Kopec, Jacek A., Kosen, Soewarta, Kotsakis, Georgios A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kudom, Andreas A., Kuipers, Ernst J., Kumar, G. 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C., Schottker, Ben, Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shackelford, Katya A., Shaheen, Amira, Shaikh, Masood Ali, Sharma, Rajesh, Sharma, Upasana, Shen, Jiabin, Shepard, Donald S., Sheth, Kevin N., Shibuya, Kenji, Shin, Min-Jeong, Shiri, Rahman, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Alves Silveira, Dayane Gabriele, Singh, Abhishek, Singh, Jasvinder A., Singh, Om Prakash, Singh, Prashant Kumar, Sivonda, Anna, Skirbekk, Vegard, Skogen, Jens Christoffer, Sligar, Amber, Silwa, Karen, Soljak, Michael, Soreide, Kjetil, Soriano, Joan B., Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J., Steiner, Timothy J., Steinke, Sabine, Stovner, Lars, Stroumpoulis, Konstantinos, Sunguya, Bruno F., Sur, Patrick, Swaminathan, Soumya, Sykes, Bryan L., Szoeke, Cassandra E. 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A., Park, Eun-Kee, Parsaeian, Mahboubeh, de Azeredo Passos, Valeria Maria, Paternina Caicedo, Angel J., Patten, Scott B., Patton, George C., Pereira, David M., Perez-Padilla, Rogelio, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frederic B., Pillay, Julian David, Pishgar, Farhad, Plass, Dietrich, Platts-Mills, James A., Polinder, Suzanne, Pond, Constance D., Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M., Qorbani, Mostafa, Rabiee, Rynaz H. S., Radfar, Amir, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Rao, Puja, Refaat, Amany H., Reitsma, Marissa B., Remuzzi, Giuseppe, Resnikofff, Serge, Reynolds, Alex, Ribeiro, Antonio L., Rios Blancas, Maria Jesus, Rolm, Hirbo Shore, Rojas-Rueda, David, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Roy, Ambuj, Sagar, Rajesh, Sahathevan, Ramesh, Sanabria, Juan R., Dolores Sanchez-Nino, Maria, Santos, Itamar S., Santos, Joao Vasco, Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schaub, Michael P., Schmidt, Maria Ines, Schneider, Ione J. C., Schottker, Ben, Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shackelford, Katya A., Shaheen, Amira, Shaikh, Masood Ali, Sharma, Rajesh, Sharma, Upasana, Shen, Jiabin, Shepard, Donald S., Sheth, Kevin N., Shibuya, Kenji, Shin, Min-Jeong, Shiri, Rahman, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Alves Silveira, Dayane Gabriele, Singh, Abhishek, Singh, Jasvinder A., Singh, Om Prakash, Singh, Prashant Kumar, Sivonda, Anna, Skirbekk, Vegard, Skogen, Jens Christoffer, Sligar, Amber, Silwa, Karen, Soljak, Michael, Soreide, Kjetil, Soriano, Joan B., Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J., Steiner, Timothy J., Steinke, Sabine, Stovner, Lars, Stroumpoulis, Konstantinos, Sunguya, Bruno F., Sur, Patrick, Swaminathan, Soumya, Sykes, Bryan L., Szoeke, Cassandra E. I., Tabares-Seisdedos, Rafael, Takala, Jukka S., Landon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Bineyam, Taylor, Hugh R., Te Ao, Braden J., Tedla, Bemnet Amare, Terkawi, Abdullah Sulieman, Thomson, Alan J., Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Tran, Bach Xuan, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Uneke, Chigozie Jesse, Uthman, Olalekan A., van Gool, Coen H., Varakin, Yuri Y., Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Verma, Raj Kumar, Violante, Francesco S., Vladimirov, Sergey K., Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R., Waller, Stephen G., Wang, Linhong, Watkins, David A., Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Westerman, Ronny, White, Richard A., Williams, Hywel C., Wiysonge, Charles Shey, Wolfe, Charles D. A., Won, Sungho, Woodbrook, Rachel, Wubshet, Mamo, Xavier, Denis, Xu, Gelin, Yadav, Ajit Kumar, Yan, Lijing L., Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yebyo, Henock Gebremedhin, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z., Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zhou, Maigeng, Zodpey, Sanjay, Zuhlke, Liesl Joanna, and Murray, Christopher J. L.

Abstract

Background Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. Methods We estimated incidence and prevalence by age, sex, cause, year, and geography with a wide range of updated and standardised analytical procedures. Improvements from GBD 2013 included the addition of new data sources, updates to literature reviews for 85 causes, and the identification and inclusion of additional studies published up to November, 2015, to expand the database used for estimation of non-fatal outcomes to 60 900 unique data sources. Prevalence and incidence by cause and sequelae were determined with DisMod-MR 2.1, an improved version of the DisMod-MR Bayesian meta-regression tool first developed for GBD 2010 and GBD 2013. For some causes, we used alternative modelling strategies where the complexity of the disease was not suited to DisMod-MR 2.1 or where incidence and prevalence needed to be determined from other data. For GBD 2015 we created a summary indicator that combines measures of income per capita, educational attainment, and fertility (the Socio-demographic Index [SDI]) and used it to compare observed patterns of health loss to the expected pattern for countries or locations with similar SDI scores. Findings We generated 9.3 billion estimates from the various combinations of prevalence, incidence, and YLDs for causes, sequelae, and impairments by age, sex, geography, and year. In 2015, two causes had acute incidences in excess of 1 billion: upper respiratory infections (17.2 bi

Published
2016
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24. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015 : a systematic analysis for the Global Burden of Disease Study 2015

Author

Forouzanfar, Mohammad H., Afshin, Ashkan, Alexander, Lily T., Anderson, H. 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M., Aldhahri, Saleh Fahed, Aldridge, Robert William, Alemu, Zewdie Aderaw, Ali, Raghib, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Alsharif, Ubai, Altirkawi, Khalid A., Alvarez Martin, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T., Amberbir, Alemayehu, Amegah, Adeladza Kofi, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H., Anderson, Benjamin O., Antonio, Carl Abelardo T., Anwar, Palwasha, Ärnlöv, Johan, Artaman, Al, Asayesh, Hamid, Asghar, Rana Jawad, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G. 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Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Bahit, Maria C., Balakrishnan, Kalpana, Barac, Aleksandra, Barber, Ryan M., Barker-Collo, Suzanne L., Baernighausen, Till, Barquera, Simon, Barregard, Lars, Barrero, Lope H., Basu, Sanjay, Bans, Carolina, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Bell, Michelle L., Bello, Aminu K., Bennett, Derrick A., Bensenor, Isabela M., Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhansali, Anil, Bhatt, Samir, Biadgilign, Sibhatu, Bikbov, Boris, Bisanzio, Donal, Bjertness, Espen, Blore, Jed D., Borschmann, Rohan, Boufous, Soufiane, Bourne, Rupert R. A., Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Broday, David M., Brugha, Traolach S., Brunekreef, Bert, Butt, Zahid A., Cahill, Leah E., Calabria, Bianca, Ricardo Campos-Nonato, Ismael, Cardenas, Rosario, Carpenter, David, Casey, Daniel C., Castaneda-Oquela, Carlos A., Castillo Rivas, Jacqueline, Estanislao Castro, Ruben, Catala-Lopez, Ferran, Chang, Jung-Chen, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Choi, Jee-Young Jasmine, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Coates, Matthew M., Colquhoun, Samantha M., Cooper, Leslie Trumbull, Cooperrider, Kimberly, Cornaby, Leslie, Cortinovis, Monica, Crump, John A., Cuevas-Nasu, Lucia, Damasceno, Albertino, Dandona, Rakhi, Darby, Sarah C., Dargan, Paul I., das Neves, Jose, Davis, Adrian C., Davletov, Kairat, Filipa de Castro, E., De la Cruz-Gongora, Vanessa, De Leo, Diego, Degenhardt, Louisa, Del Gobbo, Liana C., del Pozo-Cruz, Borja, Dellavalle, Robert P., Deribew, Amare, Des Jarlais, Don C., Dharmaratne, Samath D., Dhillon, Preet K., Diaz-Tome, Cesar, Dicker, Daniel, Ding, Eric L., Dorsey, E. Ray, Doyle, Kerrie E., Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Elyazar, Iqbal, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Erskine, Holly E., Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Aquino Faraon, Emerito Jose, Farid, Talha A., Sofia E Sa Farinha, Carla, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fischer, Florian, Fitchett, Joseph R. A., Fleming, Tom, Foigt, Nataliya, Foreman, Kyle, Fowkes, F. Gerry R., Franklin, Richard C., Fuerst, Thomas, Futran, Neal D., Gakidou, Emmanuela, Garcia-Basteiro, Alberto L., Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Geleijnse, Johanna M., Gessner, Bradford D., Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Goenka, Shifalika, Carmen Gomez-Cabrera, Mari, Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Gugnani, Harish Chander, Guillemin, Francis, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gutierrez, Reyna A., Haagsma, Juanita A., Hafezi-Nejad, Nima, Haile, Demewoz, Hailu, Gessessew Bugssa, Halasa, Yara A., Hamadeh, Randah Ribhi, Hamidi, Samer, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Hassanvand, Mohammad Sadegh, Hassen, Tahir Ahmed, Havmoeller, Rasmus, Beatriz Heredia-Pi, Ileana, Francisco Hernandez-Llanes, Norberto, Heydarpour, Pouria, Hoek, Hans W., Hoffman, Howard J., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J., Husseini, Abdullatif, Hutchings, Sally J., Huybrechts, Inge, Iburg, Kim Moesgaard, Idrisov, Bulat T., Ileanu, Bogdan Vasile, Inoue, Manami, Jacobs, Troy A., Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Jansen, Henrica A. F. M., Jassal, Simerjot K., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jha, Vivekanand, Jiang, Ying, Jibat, Tariku, Jin, Ye, Johnson, Catherine O., Jonas, Jost B., Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, Andre, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S., Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khatibzadeh, Shahab, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Cho-il, Kim, Daniel, Kimokoti, Ruth W., Kissoon, Niranjan, Kivipelto, Miia, Knibbs, Luke D., Kokubo, Yoshihiro, Kopec, Jacek A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Kromhout, Hans, Krueger, Hans, Ku, Tiffany, Defo, Barthelemy Kuate, Kuchenbecker, Ricardo S., Bicer, Burcu Kucuk, Kuipers, Ernst J., Kumar, G. Anil, Kwan, Gene F., Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lan, Qing, Larsson, Anders, Latif, Asma Abdul, Beatriz Lawrynowicz, Alicia Elena, Leasher, Janet L., Leigh, James, Leung, Janni, Levi, Miriam, Li, Xiaohong, Li, Yichong, Liang, Juan, Liu, Shiwei, Lloyd, Belinda K., Logroscino, Giancarlo, Lotufo, Paulo A., Lunevicius, Raimundas, Maclntyre, Michael, Mahdavi, Mandi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manamo, Wondimu Ayele Ayele, Mapoma, Chabila C., Marcenes, Wagner, Martin, Randall V., Martinez-Raga, Jose, Masiye, Felix, Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M., McGrath, John J., McKee, Martin, Meaney, Peter A., Medina, Catalina, Mehari, Alem, Mena-Rodriguez, Fabiola, Mekonnen, Alemayehu B., Melaku, Yohannes Adama, Memish, Ziad A., Mendoza, Walter, Mensink, Gert B. M., Meretoja, Atte, Meretoja, Tuomo J., Mesfin, Yonatan Moges, Mhimbira, Francis Apolinary, Miller, Ted R., Mills, Edward J., Mirarefin, Mojde, Misganaw, Awoke, Mock, Charles N., Mohammadi, Alireza, Mohammed, Shafiu, Mola, Glen Liddell D., Monasta, Lorenzo, Montanez Hernandez, Julio Cesar, Montico, Marcella, Morawska, Lidia, Mori, Rintaro, Mozaffarian, Dariush, Mueller, Ulrich O., Mullany, Erin, Mumford, John Everett, Murthy, Gudlavalleti Venkata Satyanarayana, Nachega, Jean B., Naheed, Aliya, Nangia, Vinay, Nassiri, Nariman, Newton, John N., Ng, Marie, Nguyen, Quyen Le, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olivares, Pedro R., Olsen, Helen, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Opio, John Nelson, Oren, Eyal, Orozco, Ricardo, Ortiz, Alberto, Ota, Erika, Mahesh, P. A., Pana, Adrian, Park, Eun-Kee, Parry, Charles D., Parsaeian, Mahboubeh, Patel, Tejas, Caicedo, Angel J. Paternina, Patil, Snehal T., Patten, Scott B., Patton, George C., Pearce, Neil, Pereira, David M., Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frederic B., Pillay, Julian David, Plass, Dietrich, Polinder, Suzanne, Pond, Constance D., Pope, C. Arden, Pope, Daniel, Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prasad, Noela M., Qorbani, Mostafa, Rabiee, Rynaz H. S., Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Raju, Murugesan, Ram, Usha, Rana, Saleem M., Ranganathan, Kavitha, Rao, Puja, Razo Garcia, Christian Aspacia, Refaat, Amany H., Rehm, Colin D., Rehm, Jurgen, Reinig, Nikolas, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L., Rivera, Juan A., Rolm, Hirbo Shore, Rodriguez, Anna, Rodriguez-Ramirez, Sonia, Rojas-Rueda, David, Roman, Yesenia, Ronfani, Luca, Roshandel, Gholamreza, Rothenbacher, Dietrich, Roy, Ambuj, Saleh, Muhammad Muhammad, Sanabria, Juan R., Dolores Sanchez-Nino, Maria, Sanchez-Pimienta, Tania G., Sandar, Logan, Santomauro, Damian F., Santos, Itamar S., Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schmidhuber, Josef, Schmidt, Maria Ines, Schneider, Ione J. C., Schoettker, Ben, Schutte, Aletta E., Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shaheen, Amira, Shahraz, Saeid, Shaikh, Masood Ali, Levy, Teresa Shamah, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shen, Jiabin, Sheth, Kevin N., Shi, Peilin, Shibuya, Kenji, Shigematsu, Mika, Shin, Min-Jeong, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Alves Silveira, Dayane Gabriele, Silverberg, Jonathan I., Simard, Edgar P., Sindi, Shireen, Singh, Abhishek, Singh, Jasvinder A., Singh, Prashant Kumar, Slepak, Erica Leigh, Soljak, Michael, Soneji, Samir, Sorensen, Reed J. D., Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stathopoulou, Vasiliki, Steckling, Nadine, Steel, Nicholas, Stein, Dan J., Stein, Murray B., Stockl, Heidi, Stranges, Saverio, Stroumpoulis, Konstantinos, Sunguya, Bruno F., Swaminathan, Soumya, Sykes, Bryan L., Szoeke, Cassandra E. I., Tabares-Seisdedos, Rafael, Takahashi, Ken, Talongwa, Roberto Tchio, Landon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Belaynew Wasie, Taylor, Hugh R., Tedla, Bemnet Amare, Tefera, Worku Mekonnen, Tegegne, Teketo Kassaw, Tekle, Dejen Yemane, Terkawi, Abdullah Sulieman, Thakur, J. S., Thomas, Bernadette A., Thomas, Matthew Lloyd, Thomson, Alan J., Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Tillmann, Taavi, Tobe-Gai, Ruoyan, Tobollik, Myriam, Topor-Madry, Roman, Topouzis, Fotis, Towbin, Jeffrey Allen, Tran, Bach Xuan, Dimbuene, Zacharie Tsala, Tsilimparis, Nikolaos, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Uneke, Chigozie Jesse, Uthman, Olalekan A., van Donkelaar, Aaron, van Os, Jim, Varakin, Yuri Y., Vasankari, Tommi, Veerman, J. Lennert, Venketasubramanian, Narayanaswamy, Violante, Francesco S., Vollset, Stein Emil, Wagner, Gregory R., Waller, Stephen G., Wang, JianLi, Wang, Linhong, Wang, Yanping, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A., Wijeratne, Tissa, Wiysonge, Charles Shey, Wolfe, Charles D. A., Won, Sungho, Woolf, Anthony D., Wubshet, Mamo, Xavier, Denis, Xu, Gelin, Yadav, Ajit Kumar, Yakob, Bereket, Yalew, Ayalnesh Zemene, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z., Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zhu, Jun, Zipkin, Ben, Zodpey, Sanjay, Zuhlke, Liesl Joanna, and Murray, Christopher J. L.

Abstract

Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors-the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accou

Published
2016
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25. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015

Author

University of Helsinki, Clinicum, University of Helsinki, Department of Neurosciences, University of Helsinki, Department of Surgery, University of Helsinki, Department of Medical Genetics, Forouzanfar, Mohammad H., Afshin, Ashkan, Alexander, Lily T., Anderson, H. Ross, Bhutta, Zulficiar A., Biryukov, Stan, Brauer, Michael, Burnett, Richard, Cercy, Kelly, Charlson, Fiona J., Cohen, Aaron J., Dandona, Lalit, Estep, Kara, Ferrari, Alize J., Frostad, Joseph J., Fullman, Nancy, Gething, Peter W., Godwin, William W., Griswold, Max, Kinfu, Yohannes, Kyu, Hmwe H., Larson, Heidi J., Liang, Xiaofeng, Lim, Stephen S., Liu, Patrick Y., Lopez, Alan D., Lozano, Rafael, Marczak, Laurie, Mensah, George A., Mokdad, Ali H., Moradi-Lakeh, Maziar, Naghavi, Mohsen, Neal, Bruce, Reitsma, Marissa B., Roth, Gregory A., Salomon, Joshua A., Sur, Patrick J., Vos, Theo, Wagner, Joseph A., Wang, Haidong, Zhao, Yi, Zhou, Maigeng, Aasvang, Gunn Marit, Amanuel, Abajobir, Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abdulle, Abdishakur M., Abera, Semaw Ferede, Abraham, Biju, Abu-Raddad, Laith J., Abyu, Gebre Yitayih, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Ademi, Zanfina, Adou, Arsene Kouablan, Adsuar, Jose C., Agardh, Emilie Elisabet, Agarwal, Arnav, Agrawal, Anurag, Kiadaliri, Aliasghar Ahmad, Ajala, Oluremi N., Akinyemiju, Tomi F., Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K. M., Aldhahri, Saleh Fahed, Aldridge, Robert William, Alemu, Zewdie Aderaw, Ali, Raghib, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Alsharif, Ubai, Altirkawi, Khalid A., Alvarez Martin, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T., Amberbir, Alemayehu, Amegah, Adeladza Kofi, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H., Anderson, Benjamin O., Antonio, Carl Abelardo T., Anwar, Palwasha, Arnlov, Johan, Al Artaman, Asayesh, Hamid, Asghar, Rana Jawad, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Bahit, Maria C., Balakrishnan, Kalpana, Barac, Aleksandra, Barber, Ryan M., Barker-Collo, Suzanne L., Baernighausen, Till, Barquera, Simon, Barregard, Lars, Barrero, Lope H., Basu, Sanjay, Bans, Carolina, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Bell, Michelle L., Bello, Aminu K., Bennett, Derrick A., Bensenor, Isabela M., Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhansali, Anil, Bhatt, Samir, Biadgilign, Sibhatu, Bikbov, Boris, Bisanzio, Donal, Bjertness, Espen, Blore, Jed D., Borschmann, Rohan, Boufous, Soufiane, Bourne, Rupert R. A., Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Broday, David M., Brugha, Traolach S., Brunekreef, Bert, Butt, Zahid A., Cahill, Leah E., Calabria, Bianca, Ricardo Campos-Nonato, Ismael, Cardenas, Rosario, Carpenter, David, Casey, Daniel C., Castaneda-Oquela, Carlos A., Castillo Rivas, Jacqueline, Estanislao Castro, Ruben, Catala-Lopez, Ferran, Chang, Jung-Chen, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Choi, Jee-Young Jasmine, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Coates, Matthew M., Colquhoun, Samantha M., Cooper, Leslie Trumbull, Cooperrider, Kimberly, Cornaby, Leslie, Cortinovis, Monica, Crump, John A., Cuevas-Nasu, Lucia, Damasceno, Albertino, Dandona, Rakhi, Darby, Sarah C., Dargan, Paul I., das Neves, Jose, Davis, Adrian C., Davletov, Kairat, Filipa de Castro, E., De la Cruz-Gongora, Vanessa, De Leo, Diego, Degenhardt, Louisa, Del Gobbo, Liana C., del Pozo-Cruz, Borja, Dellavalle, Robert P., Deribew, Amare, Des Jarlais, Don C., Dharmaratne, Samath D., Dhillon, Preet K., Diaz-Tome, Cesar, Dicker, Daniel, Ding, Eric L., Dorsey, E. Ray, Doyle, Kerrie E., Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Elyazar, Iqbal, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Erskine, Holly E., Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Aquino Faraon, Emerito Jose, Farid, Talha A., Sofia E Sa Farinha, Carla, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fischer, Florian, Fitchett, Joseph R. A., Fleming, Tom, Foigt, Nataliya, Foreman, Kyle, Fowkes, F. Gerry R., Franklin, Richard C., Fuerst, Thomas, Futran, Neal D., Gakidou, Emmanuela, Garcia-Basteiro, Alberto L., Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Geleijnse, Johanna M., Gessner, Bradford D., Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Goenka, Shifalika, Carmen Gomez-Cabrera, Mari, Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Gugnani, Harish Chander, Guillemin, Francis, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gutierrez, Reyna A., Haagsma, Juanita A., Hafezi-Nejad, Nima, Haile, Demewoz, Hailu, Gessessew Bugssa, Halasa, Yara A., Hamadeh, Randah Ribhi, Hamidi, Samer, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Hassanvand, Mohammad Sadegh, Hassen, Tahir Ahmed, Havmoeller, Rasmus, Beatriz Heredia-Pi, Ileana, Francisco Hernandez-Llanes, Norberto, Heydarpour, Pouria, Hoek, Hans W., Hoffman, Howard J., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J., Husseini, Abdullatif, Hutchings, Sally J., Huybrechts, Inge, Iburg, Kim Moesgaard, Idrisov, Bulat T., Ileanu, Bogdan Vasile, Inoue, Manami, Jacobs, Troy A., Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Jansen, Henrica A. F. M., Jassal, Simerjot K., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jha, Vivekanand, Jiang, Ying, Jibat, Tariku, Jin, Ye, Johnson, Catherine O., Jonas, Jost B., Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, Andre, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S., Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khatibzadeh, Shahab, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Cho-il, Kim, Daniel, Kimokoti, Ruth W., Kissoon, Niranjan, Kivipelto, Miia, Knibbs, Luke D., Kokubo, Yoshihiro, Kopec, Jacek A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Kromhout, Hans, Krueger, Hans, Ku, Tiffany, Defo, Barthelemy Kuate, Kuchenbecker, Ricardo S., Bicer, Burcu Kucuk, Kuipers, Ernst J., Kumar, G. Anil, Kwan, Gene F., Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lan, Qing, Larsson, Anders, Latif, Asma Abdul, Beatriz Lawrynowicz, Alicia Elena, Leasher, Janet L., Leigh, James, Leung, Janni, Levi, Miriam, Li, Xiaohong, Li, Yichong, Liang, Juan, Liu, Shiwei, Lloyd, Belinda K., Logroscino, Giancarlo, Lotufo, Paulo A., Lunevicius, Raimundas, Maclntyre, Michael, Mahdavi, Mandi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manamo, Wondimu Ayele Ayele, Mapoma, Chabila C., Marcenes, Wagner, Martin, Randall V., Martinez-Raga, Jose, Masiye, Felix, Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M., McGrath, John J., McKee, Martin, Meaney, Peter A., Medina, Catalina, Mehari, Alem, Mena-Rodriguez, Fabiola, Mekonnen, Alemayehu B., Melaku, Yohannes Adama, Memish, Ziad A., Mendoza, Walter, Mensink, Gert B. M., Meretoja, Atte, Meretoja, Tuomo J., Mesfin, Yonatan Moges, Mhimbira, Francis Apolinary, Miller, Ted R., Mills, Edward J., Mirarefin, Mojde, Misganaw, Awoke, Mock, Charles N., Mohammadi, Alireza, Mohammed, Shafiu, Mola, Glen Liddell D., Monasta, Lorenzo, Montanez Hernandez, Julio Cesar, Montico, Marcella, Morawska, Lidia, Mori, Rintaro, Mozaffarian, Dariush, Mueller, Ulrich O., Mullany, Erin, Mumford, John Everett, Murthy, Gudlavalleti Venkata Satyanarayana, Nachega, Jean B., Naheed, Aliya, Nangia, Vinay, Nassiri, Nariman, Newton, John N., Ng, Marie, Quyen Le Nguyen, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olivares, Pedro R., Olsen, Helen, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Opio, John Nelson, Oren, Eyal, Orozco, Ricardo, Ortiz, Alberto, Ota, Erika, Mahesh, P. A., Pana, Adrian, Park, Eun-Kee, Parry, Charles D., Parsaeian, Mahboubeh, Patel, Tejas, Caicedo, Angel J. Paternina, Patil, Snehal T., Patten, Scott B., Patton, George C., Pearce, Neil, Pereira, David M., Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frederic B., Pillay, Julian David, Plass, Dietrich, Polinder, Suzanne, Pond, Constance D., Pope, C. Arden, Pope, Daniel, Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prasad, Noela M., Qorbani, Mostafa, Rabiee, Rynaz H. 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I., Tabares-Seisdedos, Rafael, Takahashi, Ken, Talongwa, Roberto Tchio, Landon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Belaynew Wasie, Taylor, Hugh R., Tedla, Bemnet Amare, Tefera, Worku Mekonnen, Tegegne, Teketo Kassaw, Tekle, Dejen Yemane, Terkawi, Abdullah Sulieman, Thakur, J. S., Thomas, Bernadette A., Thomas, Matthew Lloyd, Thomson, Alan J., Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Tillmann, Taavi, Tobe-Gai, Ruoyan, Tobollik, Myriam, Topor-Madry, Roman, Topouzis, Fotis, Towbin, Jeffrey Allen, Bach Xuan Tran, Dimbuene, Zacharie Tsala, Tsilimparis, Nikolaos, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Uneke, Chigozie Jesse, Uthman, Olalekan A., van Donkelaar, Aaron, van Os, Jim, Varakin, Yuri Y., Vasankari, Tommi, Veerman, J. Lennert, Venketasubramanian, Narayanaswamy, Violante, Francesco S., Vollset, Stein Emil, Wagner, Gregory R., Waller, Stephen G., Wang, JianLi, Wang, Linhong, Wang, Yanping, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A., Wijeratne, Tissa, Wiysonge, Charles Shey, Wolfe, Charles D. A., Won, Sungho, Woolf, Anthony D., Wubshet, Mamo, Xavier, Denis, Xu, Gelin, Yadav, Ajit Kumar, Yakob, Bereket, Yalew, Ayalnesh Zemene, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z., Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zhu, Jun, Zipkin, Ben, Zodpey, Sanjay, Zuhlke, Liesl Joanna, Murray, Christopher J. L., and GBD 2015 Risk Factors

Abstract

Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors-the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accou

Published
2016

26. Weight Perception, Satisfaction, Control, and Low Energy Dietary Reporting in the US Adult Population : Results from the National Health and Nutrition Examination Survey 2007-2012

Author

Tyrovolas, Stefanos, Koyanagi, Ai, Stickley, Andrew, Maria Haro, Josep, Tyrovolas, Stefanos, Koyanagi, Ai, Stickley, Andrew, and Maria Haro, Josep

Abstract

Background Prior research has indicated that several factors are associated with low energy dietary reporting; however, there is comparatively little information on the association between body image, weight control, and low energy reporting. Objective Our aim was to evaluate the association between low energy reporting and aspects of weight perception, satisfaction, and control in a nationally representative US adult sample. Design This was a cross-sectional study. Participants/setting Data were analyzed from 13,581 adults aged 20 years and older who participated in the 2007-2012 National Health and Nutrition Examination Survey. Data on sociodemographic, clinical, and lifestyle characteristics, and weight perception, satisfaction, and control were collected. The ratio of reported energy intake to estimated basal metabolic rate (EI/BMR) was calculated and used for the assessment of low energy reporting. Main outcome measures The relationship of low energy reporting with various aspects of weight perception, satisfaction, and control was evaluated. Statistical analyses performed Multivariable logistic regression was used to assess the association between the variables. Results Low energy reporters were significantly more likely to consider themselves overweight (perception), want to weigh less (satisfaction), and to have tried to lose weight in the past 12 months (control). Compared with having no desire for weight change, wanting to weigh less was associated with 1.28 (95% CI 1.07 to 1.53) times higher odds for low energy reporting. Trying to lose weight was also associated with low energy reporting (odds ratio = 1.56; 95% CI 1.38 to 1.76). Effect modification by obesity status was observed for the weight perception, satisfaction, and control variables where the odds ratios of these factors for low energy reporting were higher among those who were not obese. Conclusion Weight perception, satisfaction, and control are related to low energy reporting, and should be ta

Published
2016
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27. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015:a systematic analysis for the Global Burden of Disease Study 2015

Author

Vos, Theo, Allen, Christine, Arora, Megha, Barber, Ryan M., Bhutta, Zulfiqar A., Brown, Alexandria, Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Z., Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J., Dilegge, Tina, Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Tom, Forouzanfar, Mohammad H., Fullman, Nancy, Gething, Peter W., Goldberg, Ellen M., Graetz, Nicholas, Haagsma, Juanita A., Johnson, Catherine O., Kassebaum, Nicholas J., Kawashima, Toana, Kemmer, Laura, Khalil, Ibrahim A., Kinfu, Yohannes, Kyu, Hmwe H., Leung, Janni, Liang, Xiaofeng, Lim, Stephen S., Lopez, Alan D., Lozano, Rafael, Marczak, Laurie, Mensah, George A., Mokdad, Ali H., Naghavi, Mohsen, Nguyen, Grant, Nsoesie, Elaine, Olsen, Helen, Pigott, David M., Pinho, Christine, Rankin, Zane, Reinig, Nikolas, Salomon, Joshua A., Sandar, Logan, Smith, Alison, Stanaway, Jeffrey, Steiner, Caitlyn, Teeple, Stephanie, Thomas, Bernadette A., Troeger, Christopher, Wagner, Joseph A., Wang, Haidong, Wanga, Valentine, Whiteford, Harvey A., Zoeckler, Leo, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abraham, Biju, Abubakar, Ibrahim, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M. E., Ackerman, Ilana N., Adebiyi, Akindele Olupelumi, Ademi, Zanfina, Adou, Arsene Kouablan, Afanvi, Kossivi Agbelenko, Agardh, Emilie Elisabet, Agarwal, Arnav, Kiadaliri, Aliasghar Ahmad, Ahmadieh, Hamid, Ajala, Oluremi N., Akinyemi, Rufus Olusola, Akseer, Nadia, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K. M., Aldhahri, Saleh Fahed, Alegretti, Miguel Angel, Alemu, Zewdie Aderaw, Alexander, Lily T., Alhabib, Samia, Ali, Raghib, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Amberbir, Alemayehu, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H., Anderson, Gregory M., Anderson, Benjamin, Antonio, Carl Abelardo T., Aregay, Atsede Fantahun, Arnlov, Johan, Al Artaman, Asayesh, Hamid, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Banerjee, Amitava, Barac, Aleksandra, Barker-Collo, Suzanne L., Barnighausen, Till, Barregard, Lars, Barrero, Lope H., Basu, Arindam, Bazargan-Hejazi, Shahrzad, Bell, Brent, Bell, Michelle L., Bennett, Derrick A., Bensenor, Isabela M., Benzian, Habib, Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhatt, Samir, Biadgilign, Sibhatu, Bienhofff, Kelly, Bikbov, Boris, Biryukov, Stan, Bisanzio, Donal, Bjertness, Espen, Blore, Jed, Borschmann, Rohan, Boufous, Soufiane, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J. K., Brown, Jonathan, Buchbinder, Rachelle, Buckle, Geoffrey Colin, Butt, Zahid A., Calabria, Bianca, Ricardo Campos-Nonato, Ismael, Cesar Campuzano, Julio, Carabin, Helene, Cardenas, Rosario, Carpenter, David O., Carrero, Juan Jesus, Castaneda-Orjuela, Carlos A., Castillo Rivas, Jacqueline, Catala-Lopez, Ferran, Chang, Jung-Chen, Chiang, Peggy Pei-Chia, Chibueze, Chioma Ezinne, Chisumpa, Vesper Hichilombwe, Choi, Jee-Young Jasmine, Chowdhury, Rajiv, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Cirillo, Massimo, Coates, Matthew M., Colquhoun, Samantha M., Cooper, Cyrus, Cortinovis, Monica, Crump, John A., Damtew, Solomon Abrha, Dandona, Rakhi, Daoud, Farah, Dargan, Paul I., das Neves, Jose, Davey, Gail, Davis, Adrian C., De Leo, Diego, Degenhardt, Louisa, Del Gobbo, Liana C., Dellavalle, Robert P., Deribe, Kebede, Deribew, Amare, Derrett, Sarah, Des Jarlais, Don C., Dharmaratne, Samath D., Dhillon, Preet K., Diaz-Torne, Cesar, Ding, Eric L., Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Ebrahimi, Hedyeh, Ellenbogen, Richard G., Elyazar, Iqbal, Endres, Matthias, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshrati, Babak, Estep, Kara, Farid, Talha A., Sofia e Sa Farinha, Carla, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Felson, David T., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fernandes, Joao C., Fischer, Florian, Fitchett, Joseph R. A., Foreman, Kyle, Fowkes, Gerry R., Fox, Jordan, Franklin, Richard C., Friedman, Joseph, Frostad, Joseph, Furst, Thomas, Futran, Neal D., Gabbe, Belinda, Ganguly, Parthasarathi, Gankpe, Fortune Gbetoho, Gebre, Teshome, Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Geleijnse, Johanna M., Gessner, Bradford D., Gibney, Katherine B., Ginawi, Ibrahim Abdelmageem Mohamed, Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Glaser, Elizabeth, Godwin, William W., Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Grainger, Rebecca, Greaves, Felix, Guillemin, Francis, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Gutierrez, Reyna A., Haile, Demewoz, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Halasa, Yara A., Hamadeh, Randah Ribhi, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Havmøller, Rasmus, Hay, Roderick J., Beatriz Heredia-Pi, Ileana, Heydarpour, Pouria, Hoek, Hans W., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hoy, Damian G., Htet, Aung Soe, Huang, Hsiang, Huang, John J., Huynh, Chantal, Iannarone, Marissa, Iburg, Kim Moesgaard, Innos, Kaire, Inoue, Manami, Iyer, Veena J., Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jensen, Paul N., Jiang, Ying, Jibat, Tariku, Jimenez-Corona, Aida, Jin, Ye, Jonas, Jost B., Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, Andre, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khaiff, Abdur Rahman, Khaiff, Ejaz Ahmad, Khang, Young-Ho, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Pauline, Kim, Cho-il, Kim, Daniel, Kim, Yun Jin, Kissoon, Niranjan, Knibbs, Luke D., Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kolte, Dhaval, Kopec, Jacek A., Kosen, Soewarta, Kotsakis, Georgios A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kudom, Andreas A., Kuipers, Ernst J., Kumar, G. Anil, Kutz, Michael, Kwan, Gene F., Lal, Aparna, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lam, Jennifer O., Langan, Sinead M., Larsson, Anders, Lavados, Pablo M., Leasher, Janet L., Leigh, James, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K., Lo, Warren D., Logroscino, Giancarlo, Looker, Katharine J., Lotufo, Paulo A., Lunevicius, Raimundas, Lyons, Ronan A., Mackay, Mark T., Abd El Razek, Mohammed Magdy, Mahdavi, Mandi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Marcenes, Wagner, Margolis, David Joel, Martinez-Raga, Jose, Masiye, Felix, Massano, Joao, McGarvey, Stephen Theodore, McGrath, John J., McKee, Martin, McMahon, Brian J., Meaney, Peter A., Mehari, Alem, Meija-Rodriguez, Fabiola, Mekonnen, Alemayehu B., Melaku, Yohannes Adama, Memiah, Peter, Memish, Ziad A., Mendoza, Walter, Meretoja, Atte, Meretoja, Tuomo J., Mhimbira, Francis Apolinary, Miller, Ted R., Mills, Edward J., Mirarefin, Mojde, Mitchell, Philip B., Mock, Charles N., Mohammadi, Alireza, Mohammed, Shafiu, Monasta, Lorenzo, Montanez Hernandez, Julio Cesar, Montico, Marcella, Mooney, Meghan D., Moradi-Lakeh, Maziar, Morawska, Lidia, Mueller, Ulrich O., Mullany, Erin, Mumford, John Everett, Murdoch, Michele E., Nachega, Jean B., Nagel, Gabriele, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Newton, John N., Ng, Marie, Ngalesoni, Frida Namnyak, Quyen Le Nguyen, Nisar, Muhammad Imran, Nkamedjie Pete, Patrick Martial, Nona, Joan M., Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nunes, Bruno P., Ogbo, Felix Akpojene, Oh, In-Hwan, Ohkubo, Takayoshi, Olivares, Pedro R., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ortiz, Alberto, Osman, Majdi, Ota, Erika, Mahesh, P. A., Park, Eun-Kee, Parsaeian, Mahboubeh, de Azeredo Passos, Valeria Maria, Paternina Caicedo, Angel J., Patten, Scott B., Patton, George C., Pereira, David M., Perez-Padilla, Rogelio, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frederic B., Pillay, Julian David, Pishgar, Farhad, Plass, Dietrich, Platts-Mills, James A., Polinder, Suzanne, Pond, Constance D., Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M., Qorbani, Mostafa, Rabiee, Rynaz H. S., Radfar, Amir, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Rao, Puja, Refaat, Amany H., Reitsma, Marissa B., Remuzzi, Giuseppe, Resnikofff, Serge, Reynolds, Alex, Ribeiro, Antonio L., Rios Blancas, Maria Jesus, Rolm, Hirbo Shore, Rojas-Rueda, David, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Roy, Ambuj, Sagar, Rajesh, Sahathevan, Ramesh, Sanabria, Juan R., Dolores Sanchez-Nino, Maria, Santos, Itamar S., Santos, Joao Vasco, Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schaub, Michael P., Schmidt, Maria Ines, Schneider, Ione J. C., Schottker, Ben, Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shackelford, Katya A., Shaheen, Amira, Shaikh, Masood Ali, Sharma, Rajesh, Sharma, Upasana, Shen, Jiabin, Shepard, Donald S., Sheth, Kevin N., Shibuya, Kenji, Shin, Min-Jeong, Shiri, Rahman, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Alves Silveira, Dayane Gabriele, Singh, Abhishek, Singh, Jasvinder A., Singh, Om Prakash, Singh, Prashant Kumar, Sivonda, Anna, Skirbekk, Vegard, Skogen, Jens Christoffer, Sligar, Amber, Silwa, Karen, Soljak, Michael, Soreide, Kjetil, Soriano, Joan B., Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J., Steiner, Timothy J., Steinke, Sabine, Stovner, Lars, Stroumpoulis, Konstantinos, Sunguya, Bruno F., Sur, Patrick, Swaminathan, Soumya, Sykes, Bryan L., Szoeke, Cassandra E. I., Tabares-Seisdedos, Rafael, Takala, Jukka S., Landon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Bineyam, Taylor, Hugh R., Te Ao, Braden J., Tedla, Bemnet Amare, Terkawi, Abdullah Sulieman, Thomson, Alan J., Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Tran, Bach Xuan, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Uneke, Chigozie Jesse, Uthman, Olalekan A., van Gool, Coen H., Varakin, Yuri Y., Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Verma, Raj Kumar, Violante, Francesco S., Vladimirov, Sergey K., Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R., Waller, Stephen G., Wang, Linhong, Watkins, David A., Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Westerman, Ronny, White, Richard A., Williams, Hywel C., Wiysonge, Charles Shey, Wolfe, Charles D. A., Won, Sungho, Woodbrook, Rachel, Wubshet, Mamo, Xavier, Denis, Xu, Gelin, Yadav, Ajit Kumar, Yan, Lijing L., Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yebyo, Henock Gebremedhin, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z., Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zhou, Maigeng, Zodpey, Sanjay, Zuhlke, Liesl Joanna, Murray, Christopher J. L., Vos, Theo, Allen, Christine, Arora, Megha, Barber, Ryan M., Bhutta, Zulfiqar A., Brown, Alexandria, Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Z., Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J., Dilegge, Tina, Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Tom, Forouzanfar, Mohammad H., Fullman, Nancy, Gething, Peter W., Goldberg, Ellen M., Graetz, Nicholas, Haagsma, Juanita A., Johnson, Catherine O., Kassebaum, Nicholas J., Kawashima, Toana, Kemmer, Laura, Khalil, Ibrahim A., Kinfu, Yohannes, Kyu, Hmwe H., Leung, Janni, Liang, Xiaofeng, Lim, Stephen S., Lopez, Alan D., Lozano, Rafael, Marczak, Laurie, Mensah, George A., Mokdad, Ali H., Naghavi, Mohsen, Nguyen, Grant, Nsoesie, Elaine, Olsen, Helen, Pigott, David M., Pinho, Christine, Rankin, Zane, Reinig, Nikolas, Salomon, Joshua A., Sandar, Logan, Smith, Alison, Stanaway, Jeffrey, Steiner, Caitlyn, Teeple, Stephanie, Thomas, Bernadette A., Troeger, Christopher, Wagner, Joseph A., Wang, Haidong, Wanga, Valentine, Whiteford, Harvey A., Zoeckler, Leo, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abraham, Biju, Abubakar, Ibrahim, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M. E., Ackerman, Ilana N., Adebiyi, Akindele Olupelumi, Ademi, Zanfina, Adou, Arsene Kouablan, Afanvi, Kossivi Agbelenko, Agardh, Emilie Elisabet, Agarwal, Arnav, Kiadaliri, Aliasghar Ahmad, Ahmadieh, Hamid, Ajala, Oluremi N., Akinyemi, Rufus Olusola, Akseer, Nadia, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K. M., Aldhahri, Saleh Fahed, Alegretti, Miguel Angel, Alemu, Zewdie Aderaw, Alexander, Lily T., Alhabib, Samia, Ali, Raghib, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Amberbir, Alemayehu, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H., Anderson, Gregory M., Anderson, Benjamin, Antonio, Carl Abelardo T., Aregay, Atsede Fantahun, Arnlov, Johan, Al Artaman, Asayesh, Hamid, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Banerjee, Amitava, Barac, Aleksandra, Barker-Collo, Suzanne L., Barnighausen, Till, Barregard, Lars, Barrero, Lope H., Basu, Arindam, Bazargan-Hejazi, Shahrzad, Bell, Brent, Bell, Michelle L., Bennett, Derrick A., Bensenor, Isabela M., Benzian, Habib, Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhatt, Samir, Biadgilign, Sibhatu, Bienhofff, Kelly, Bikbov, Boris, Biryukov, Stan, Bisanzio, Donal, Bjertness, Espen, Blore, Jed, Borschmann, Rohan, Boufous, Soufiane, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J. K., Brown, Jonathan, Buchbinder, Rachelle, Buckle, Geoffrey Colin, Butt, Zahid A., Calabria, Bianca, Ricardo Campos-Nonato, Ismael, Cesar Campuzano, Julio, Carabin, Helene, Cardenas, Rosario, Carpenter, David O., Carrero, Juan Jesus, Castaneda-Orjuela, Carlos A., Castillo Rivas, Jacqueline, Catala-Lopez, Ferran, Chang, Jung-Chen, Chiang, Peggy Pei-Chia, Chibueze, Chioma Ezinne, Chisumpa, Vesper Hichilombwe, Choi, Jee-Young Jasmine, Chowdhury, Rajiv, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Cirillo, Massimo, Coates, Matthew M., Colquhoun, Samantha M., Cooper, Cyrus, Cortinovis, Monica, Crump, John A., Damtew, Solomon Abrha, Dandona, Rakhi, Daoud, Farah, Dargan, Paul I., das Neves, Jose, Davey, Gail, Davis, Adrian C., De Leo, Diego, Degenhardt, Louisa, Del Gobbo, Liana C., Dellavalle, Robert P., Deribe, Kebede, Deribew, Amare, Derrett, Sarah, Des Jarlais, Don C., Dharmaratne, Samath D., Dhillon, Preet K., Diaz-Torne, Cesar, Ding, Eric L., Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Ebrahimi, Hedyeh, Ellenbogen, Richard G., Elyazar, Iqbal, Endres, Matthias, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshrati, Babak, Estep, Kara, Farid, Talha A., Sofia e Sa Farinha, Carla, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Felson, David T., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fernandes, Joao C., Fischer, Florian, Fitchett, Joseph R. A., Foreman, Kyle, Fowkes, Gerry R., Fox, Jordan, Franklin, Richard C., Friedman, Joseph, Frostad, Joseph, Furst, Thomas, Futran, Neal D., Gabbe, Belinda, Ganguly, Parthasarathi, Gankpe, Fortune Gbetoho, Gebre, Teshome, Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Geleijnse, Johanna M., Gessner, Bradford D., Gibney, Katherine B., Ginawi, Ibrahim Abdelmageem Mohamed, Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Glaser, Elizabeth, Godwin, William W., Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Grainger, Rebecca, Greaves, Felix, Guillemin, Francis, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Gutierrez, Reyna A., Haile, Demewoz, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Halasa, Yara A., Hamadeh, Randah Ribhi, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Harikrishnan, Sivadasanpillai, Maria Haro, Josep, Havmøller, Rasmus, Hay, Roderick J., Beatriz Heredia-Pi, Ileana, Heydarpour, Pouria, Hoek, Hans W., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hoy, Damian G., Htet, Aung Soe, Huang, Hsiang, Huang, John J., Huynh, Chantal, Iannarone, Marissa, Iburg, Kim Moesgaard, Innos, Kaire, Inoue, Manami, Iyer, Veena J., Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jensen, Paul N., Jiang, Ying, Jibat, Tariku, Jimenez-Corona, Aida, Jin, Ye, Jonas, Jost B., Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, Andre, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khaiff, Abdur Rahman, Khaiff, Ejaz Ahmad, Khang, Young-Ho, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Pauline, Kim, Cho-il, Kim, Daniel, Kim, Yun Jin, Kissoon, Niranjan, Knibbs, Luke D., Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kolte, Dhaval, Kopec, Jacek A., Kosen, Soewarta, Kotsakis, Georgios A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kudom, Andreas A., Kuipers, Ernst J., Kumar, G. Anil, Kutz, Michael, Kwan, Gene F., Lal, Aparna, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lam, Jennifer O., Langan, Sinead M., Larsson, Anders, Lavados, Pablo M., Leasher, Janet L., Leigh, James, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K., Lo, Warren D., Logroscino, Giancarlo, Looker, Katharine J., Lotufo, Paulo A., Lunevicius, Raimundas, Lyons, Ronan A., Mackay, Mark T., Abd El Razek, Mohammed Magdy, Mahdavi, Mandi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Marcenes, Wagner, Margolis, David Joel, Martinez-Raga, Jose, Masiye, Felix, Massano, Joao, McGarvey, Stephen Theodore, McGrath, John J., McKee, Martin, McMahon, Brian J., Meaney, Peter A., Mehari, Alem, Meija-Rodriguez, Fabiola, Mekonnen, Alemayehu B., Melaku, Yohannes Adama, Memiah, Peter, Memish, Ziad A., Mendoza, Walter, Meretoja, Atte, Meretoja, Tuomo J., Mhimbira, Francis Apolinary, Miller, Ted R., Mills, Edward J., Mirarefin, Mojde, Mitchell, Philip B., Mock, Charles N., Mohammadi, Alireza, Mohammed, Shafiu, Monasta, Lorenzo, Montanez Hernandez, Julio Cesar, Montico, Marcella, Mooney, Meghan D., Moradi-Lakeh, Maziar, Morawska, Lidia, Mueller, Ulrich O., Mullany, Erin, Mumford, John Everett, Murdoch, Michele E., Nachega, Jean B., Nagel, Gabriele, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Newton, John N., Ng, Marie, Ngalesoni, Frida Namnyak, Quyen Le Nguyen, Nisar, Muhammad Imran, Nkamedjie Pete, Patrick Martial, Nona, Joan M., Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nunes, Bruno P., Ogbo, Felix Akpojene, Oh, In-Hwan, Ohkubo, Takayoshi, Olivares, Pedro R., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ortiz, Alberto, Osman, Majdi, Ota, Erika, Mahesh, P. A., Park, Eun-Kee, Parsaeian, Mahboubeh, de Azeredo Passos, Valeria Maria, Paternina Caicedo, Angel J., Patten, Scott B., Patton, George C., Pereira, David M., Perez-Padilla, Rogelio, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frederic B., Pillay, Julian David, Pishgar, Farhad, Plass, Dietrich, Platts-Mills, James A., Polinder, Suzanne, Pond, Constance D., Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M., Qorbani, Mostafa, Rabiee, Rynaz H. S., Radfar, Amir, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Rao, Puja, Refaat, Amany H., Reitsma, Marissa B., Remuzzi, Giuseppe, Resnikofff, Serge, Reynolds, Alex, Ribeiro, Antonio L., Rios Blancas, Maria Jesus, Rolm, Hirbo Shore, Rojas-Rueda, David, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Roy, Ambuj, Sagar, Rajesh, Sahathevan, Ramesh, Sanabria, Juan R., Dolores Sanchez-Nino, Maria, Santos, Itamar S., Santos, Joao Vasco, Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schaub, Michael P., Schmidt, Maria Ines, Schneider, Ione J. C., Schottker, Ben, Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shackelford, Katya A., Shaheen, Amira, Shaikh, Masood Ali, Sharma, Rajesh, Sharma, Upasana, Shen, Jiabin, Shepard, Donald S., Sheth, Kevin N., Shibuya, Kenji, Shin, Min-Jeong, Shiri, Rahman, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Alves Silveira, Dayane Gabriele, Singh, Abhishek, Singh, Jasvinder A., Singh, Om Prakash, Singh, Prashant Kumar, Sivonda, Anna, Skirbekk, Vegard, Skogen, Jens Christoffer, Sligar, Amber, Silwa, Karen, Soljak, Michael, Soreide, Kjetil, Soriano, Joan B., Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J., Steiner, Timothy J., Steinke, Sabine, Stovner, Lars, Stroumpoulis, Konstantinos, Sunguya, Bruno F., Sur, Patrick, Swaminathan, Soumya, Sykes, Bryan L., Szoeke, Cassandra E. I., Tabares-Seisdedos, Rafael, Takala, Jukka S., Landon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Bineyam, Taylor, Hugh R., Te Ao, Braden J., Tedla, Bemnet Amare, Terkawi, Abdullah Sulieman, Thomson, Alan J., Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Tran, Bach Xuan, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Uneke, Chigozie Jesse, Uthman, Olalekan A., van Gool, Coen H., Varakin, Yuri Y., Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Verma, Raj Kumar, Violante, Francesco S., Vladimirov, Sergey K., Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R., Waller, Stephen G., Wang, Linhong, Watkins, David A., Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Westerman, Ronny, White, Richard A., Williams, Hywel C., Wiysonge, Charles Shey, Wolfe, Charles D. A., Won, Sungho, Woodbrook, Rachel, Wubshet, Mamo, Xavier, Denis, Xu, Gelin, Yadav, Ajit Kumar, Yan, Lijing L., Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yebyo, Henock Gebremedhin, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z., Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zhou, Maigeng, Zodpey, Sanjay, Zuhlke, Liesl Joanna, and Murray, Christopher J. L.

Published
2016

28. Characteristics of patients with depression initiating or switching antidepressant treatment: baseline analyses of the PERFORM cohort study.

Author

Maria Haro, Josep, Lamy, François-Xavier, Jönsson, Bengt, Knapp, Martin, Brignone, Mélanie, Caillou, Hugo, Chalem, Ylana, Hammer-Helmich, Lene, Rive, Benoît, and Saragoussi, Delphine

Abstract

Background: Patients who require a switch in their antidepressant therapy may have different clinical profiles and treatment needs compared with patients initiating or maintaining a first-line antidepressant therapy. Methods: The Prospective Epidemiological Research on Functioning Outcomes Related to Major depressive disorder (MDD) (PERFORM) study was a 2-year observational cohort study in outpatients with MDD in five European countries. Enrolled patients were either initiating or undergoing the first switch to an antidepressant monotherapy. Baseline data on patients' clinical status, functioning, productivity, quality of life and medical-resource use were compared in a cross-sectional baseline analysis. Results: A total of 1402 patients were enrolled, of whom 1159 (82.7%) provided analysable baseline data. The majority (78.7%) of the analysable population were initiating antidepressant treatment and most (83.6%) were enrolled and followed up by general practitioners. Compared with patients initiating antidepressants, those switching antidepressants (21.3%) tended to have more severe depressive symptoms, greater anxiety, worse health-related quality of life, greater functional impairment, greater medical-resource use and had a different medical history. Limitations included an over-representation of switches due to lack of efficacy among patients who were switching treatment, as patients were selected based on presence of depressive symptoms. Conclusions: Patients with MDD who are switching treatment for the first time have a different profile and different depression-associated health needs compared with those initiating treatment. Therapeutic management should therefore be adapted for patients who switch. [ABSTRACT FROM AUTHOR]

Published
2018
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29. Towards Horizon 2020: Challenges and advances for clinical mental health research - outcome of an expert survey

Author

van der Feltz-Cornelis, C.M., van Os, Jim, Knappe, Susanne, Schumann, Gunter, Vieta, Eduard, Wittchen, Hans-Ulrich, Lewis, Shon W., Elfeddali, I., Wahlbeck, Kristian, Linszen, Donald, Obradors-Tarrago, Carla, Maria Haro, Josep, van der Feltz-Cornelis, C.M., van Os, Jim, Knappe, Susanne, Schumann, Gunter, Vieta, Eduard, Wittchen, Hans-Ulrich, Lewis, Shon W., Elfeddali, I., Wahlbeck, Kristian, Linszen, Donald, Obradors-Tarrago, Carla, and Maria Haro, Josep

Abstract

Background: The size and increasing burden of disease due to mental disorders in Europe poses substantial challenges to its population and to the health policy of the European Union. This warrants a specific research agenda concerning clinical mental health research as one of the cornerstones of sustainable mental health research and health policy in Europe. The aim of this research was to identify the top priorities needed to address the main challenges in clinical research for mental disorders. Methods: The research was conducted as an expert survey and expert panel discussion during a scientific workshop. Results: Eighty-nine experts in clinical research and representing most European countries participated in this survey. Identified top priorities were the need for new intervention studies, understanding the diagnostic and therapeutic implications of mechanisms of disease, and research in the field of somatic-psychiatric comorbidity. The “subjectivity gap” between basic neuroscience research and clinical reality for patients with mental disorders is considered the main challenge in psychiatric research, suggesting that a shift in research paradigms is required. Conclusion: Innovations in clinical mental health research should bridge the gap between mechanisms underlying novel therapeutic interventions and the patient experience of mental disorder and, if present, somatic comorbidity. Clinical mental health research is relatively underfunded and should receive specific attention in Horizon 2020 funding programs.

Published
2014

30. Posttraumatic stress disorder associated with unexpected death of a loved one: Cross-national findings from the world mental health surveys.

Author

Atwoli, Lukoye, Stein, Dan J., King, Andrew, Petukhova, Maria, Aguilar‐Gaxiola, Sergio, Alonso, Jordi, Bromet, Evelyn J., Girolamo, Giovanni, Demyttenaere, Koen, Florescu, Silvia, Maria Haro, Josep, Karam, Elie G., Kawakami, Norito, Lee, Sing, Lepine, Jean‐Pierre, Navarro‐Mateu, Fernando, O'Neill, Siobhan, Pennell, Beth‐Ellen, Piazza, Marina, and Posada‐Villa, Jose

Subjects
POST-traumatic stress disorder, MENTAL health surveys, HISTORY of medicine, DISEASE prevalence, PUBLIC health
Abstract

Background: Unexpected death of a loved one (UD) is the most commonly reported traumatic experience in cross-national surveys. However, much remains to be learned about posttraumatic stress disorder (PTSD) after this experience. The WHO World Mental Health (WMH) survey initiative provides a unique opportunity to address these issues.Methods: Data from 19 WMH surveys (n = 78,023; 70.1% weighted response rate) were collated. Potential predictors of PTSD (respondent sociodemographics, characteristics of the death, history of prior trauma exposure, history of prior mental disorders) after a representative sample of UDs were examined using logistic regression. Simulation was used to estimate overall model strength in targeting individuals at highest PTSD risk.Results: PTSD prevalence after UD averaged 5.2% across surveys and did not differ significantly between high-income and low-middle income countries. Significant multivariate predictors included the deceased being a spouse or child, the respondent being female and believing they could have done something to prevent the death, prior trauma exposure, and history of prior mental disorders. The final model was strongly predictive of PTSD, with the 5% of respondents having highest estimated risk including 30.6% of all cases of PTSD. Positive predictive value (i.e., the proportion of high-risk individuals who actually developed PTSD) among the 5% of respondents with highest predicted risk was 25.3%.Conclusions: The high prevalence and meaningful risk of PTSD make UD a major public health issue. This study provides novel insights into predictors of PTSD after this experience and suggests that screening assessments might be useful in identifying high-risk individuals for preventive interventions. [ABSTRACT FROM AUTHOR]

Published
2017
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31. Associations between mental disorders and subsequent onset of hypertension

Author

Stein, Dan J., primary, Aguilar-Gaxiola, Sergio, additional, Alonso, Jordi, additional, Bruffaerts, Ronny, additional, de Jonge, Peter, additional, Liu, Zharoui, additional, Miguel Caldas-de-Almeida, Jose, additional, O’Neill, Siobhan, additional, Viana, Maria Carmen, additional, Al-Hamzawi, Ali Obaid, additional, Angermeyer, Mattias C., additional, Benjet, Corina, additional, de Graaf⁎, Ron, additional, Ferry, Finola, additional, Kovess-Masfety, Viviane, additional, Levinson, Daphna, additional, de Girolamo, Giovanni, additional, Florescu, Silvia, additional, Hu, Chiyi, additional, Kawakami, Norito, additional, Maria Haro, Josep, additional, Piazza, Marina, additional, Posada-Villa, Jose, additional, Wojtyniak⁎, Bogdan J., additional, Xavier, Miguel, additional, Lim, Carmen C.W., additional, Kessler, Ronald C., additional, and Scott, Kate M., additional

Published
2014
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32. The Prevalence and Correlates of Binge Eating Disorder in the World Health Organization World Mental Health Surveys

Author

Kessler, Ronald C., primary, Berglund, Patricia A., additional, Chiu, Wai Tat, additional, Deitz, Anne C., additional, Hudson, James I., additional, Shahly, Victoria, additional, Aguilar-Gaxiola, Sergio, additional, Alonso, Jordi, additional, Angermeyer, Matthias C., additional, Benjet, Corina, additional, Bruffaerts, Ronny, additional, de Girolamo, Giovanni, additional, de Graaf, Ron, additional, Maria Haro, Josep, additional, Kovess-Masfety, Viviane, additional, O’Neill, Siobhan, additional, Posada-Villa, Jose, additional, Sasu, Carmen, additional, Scott, Kate, additional, Viana, Maria Carmen, additional, and Xavier, Miguel, additional

Published
2013
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33. Global Multimorbidity Patterns: A Cross-Sectional, Population-Based, Multi-Country Study.

Author

Garin, Noe, Koyanagi, Ai, Chatterji, Somnath, Tyrovolas, Stefanos, Olaya, Beatriz, Leonardi, Matilde, Lara, Elvira, Koskinen, Seppo, Tobiasz-Adamczyk, Beata, Ayuso-Mateos, Jose Luis, Maria Haro, Josep, and Haro, Josep Maria

Subjects
COMORBIDITY, CROSS-sectional method, POPULATION aging, DISEASE prevalence, CHRONIC diseases, LOGISTIC regression analysis, OBSTRUCTIVE lung diseases, AGING, RESEARCH funding, WORLD health, SOCIOECONOMIC factors
Abstract

Background: Population ageing challenges health care systems due to the high prevalence and impact of multimorbidity in older adults. However, little is known about how chronic conditions present in certain multimorbidity patterns, which could have great impact on public health at several levels. The aim of our study was to identify and describe multimorbidity patterns in low-, middle-, and high-income countries.Methods: We analyzed data from the Collaborative Research on Ageing in Europe project (Finland, Poland, and Spain) and the World Health Organization's Study on Global Ageing and Adult Health (China, Ghana, India, Mexico, Russia, and South Africa). These cross-sectional studies obtained data from 41,909 noninstitutionalized adults older than 50 years. Exploratory factor analysis was performed to detect multimorbidity patterns. Additional adjusted binary logistic regressions were performed to identify associations between sociodemographic factors and multimorbidity.Results: Overall multimorbidity prevalence was high across countries. Hypertension, cataract, and arthritis were the most prevalent comorbid conditions. Two or three multimorbidity patterns were found per country. Several patterns were identified across several countries: "cardio-respiratory" (angina, asthma, and chronic obstructive pulmonary disease), "metabolic" (diabetes, obesity, and hypertension), and "mental-articular" (arthritis and depression).Conclusions: A high prevalence of multimorbidity occurs in older adults across countries, with low- and middle-income countries gradually approaching the figures of richer countries. Certain multimorbidity patterns are present in several countries, which suggest that common underlying etiopathogenic factors may play a role. Deeper understanding of these patterns may lead to the development of preventive actions to diminish their prevalence and also give rise to new, comprehensive approaches for the management of these co-occurring conditions. [ABSTRACT FROM AUTHOR]

Published
2016
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34. Chronic Physical Conditions and Their Association With First Onset of Suicidal Behavior in the World Mental Health Surveys

Author

Scott, Kate M., primary, Hwang, Irving, additional, Chiu, Wai-Tat, additional, Kessler, Ronald C., additional, Sampson, Nancy A., additional, Angermeyer, Matthias, additional, Beautrais, Annette, additional, Borges, Guilherme, additional, Bruffaerts, Ronny, additional, de Graaf, Ron, additional, Florescu, Silvia, additional, Fukao, Akira, additional, Maria Haro, Josep, additional, Hu, Chiyi, additional, Kovess, Viviane, additional, Levinson, Daphna, additional, Posada-Villa, José, additional, Scocco, Paolo, additional, and Nock, Matthew K., additional

Published
2010
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37. Validation of an instrument to evaluate quality of life in the aging population: WHOQOL-AGE.

Author

Félix Caballero, Francisco, Miret, Marta, Power, Mick, Chatterji, Somnath, Tobiasz-Adamczyk, Beata, Koskinen, Seppo, Leonardi, Matilde, Olaya, Beatriz, Maria Haro, Josep, and Ayuso-Mateos, José Luis

Subjects
QUALITY of life measurement, OLDER people, FACTOR analysis, CRONBACH'S alpha, TEST reliability, PSYCHOMETRICS
Abstract

Background There is a need for short, specific instruments that assess quality of life (QOL) adequately in the older adult population. The aims of the present study were to obtain evidence on the validity of the inferences that could be drawn from an instrument to measure QOL in the aging population (people 50+ years old), and to test its psychometric properties. Methods The instrument, WHOQOL-AGE, comprised 13 positive items, assessed on a five-point rating scale, and was administered to nationally representative samples (n = 9987) from Finland, Poland, and Spain. Cronbach's alpha was employed to assess internal consistency reliability, whereas the validity of the questionnaire was assessed by means of factor analysis, graded response model, Pearson's correlation coefficient and unpaired t-test. Normative values were calculated across countries and for different age groups. Results The satisfactory goodness-of-fit indices confirmed that the factorial structure of WHOQOLAGE comprises two first-order factors. Cronbach's alpha was 0.88 for factor 1, and 0.84 for factor 2. Evidence supporting a global score was found with a second-order factor model, according to the goodness-of-fit indices: CFI = 0.93, TLI = 0.91, RMSEA = 0.073. Convergent validity was estimated at r = 0.75 and adequate discriminant validity was also found. Significant differences were found between healthy individuals (74.19 ± 13.21) and individuals with at least one chronic condition (64.29 ± 16.29), supporting adequate knowngroups validity. Conclusions WHOQOL-AGE has shown good psychometric properties in Finland, Poland, and Spain. Therefore, considerable support is provided to using the WHOQOL-AGE to measure QOL in older adults in these countries, and to compare the QOL of older and younger adults. [ABSTRACT FROM AUTHOR]

Published
2013
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38. Risk factors for suicide behaviors in the observational schizophrenia outpatient health outcomes (SOHO) study.

Author

Brugnoli, Roberto, Novick, Diego, Maria Haro, Josep, Rossi, Andrea, Bortolomasi, Marco, Frediani, Sonia, and Borgherini, Giuseppe

Subjects
DISEASE risk factors, SUICIDE, SUICIDAL behavior, SCHIZOPHRENIA, OUTPATIENT medical care, MENTAL depression, DEPRESSED persons
Abstract

Background: To identify risk factors for suicide using data from a large, 3-year, multinational follow-up study of schizophrenia (SOHO study). Methods: Baseline characteristics of 8,871 adult patients with schizophrenia were included in a logistic regression post-hoc analysis comparing patients who attempted and/or committed suicide during the study with those who did not. Results: 384 (4.3%) patients attempted or committed suicide. Completed suicides were 27 (0.3%). The significant risk factors for suicide behaviors were previous suicidality, depressive symptoms, prolactin-related adverse events, male gender and history of hospitalization for schizophrenia. Conclusions: In view of the observational design of the study and the post-hoc nature of the analysis, the identified risk factors should be confirmed by ad-hoc specifically designed studies. [ABSTRACT FROM AUTHOR]

Published
2012
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39. GBD 2016 Alcohol and Drug Use Collaborators (vol 5, pg 987, 2018)

Author

Degenhardt, Louisa, Charlson, Fiona, Alize Ferrari, Santomauro, Damian, Erskine, Holly, Mantilla-Herrara, Ana, Whiteford, Harvey, Leung, Janni, Naghavi, Mohsen, Griswold, Max, Rehm, Juegen, Hall, Wayne, Sartorius, Benn, Scott, James, Vollset, Stein Emil, Knudsen, Ann Kristin, Maria Haro, Josep, Patton, George, Kopec, Jacek, Malta, Deborah Carvalho, Topor-Madry, Roman, Mcgrath, John, Haagsma, Juanita, Allebeck, Peter, Phillips, Michael, Salomon, Joshua, Hay, Simon, Foreman, Kyle, Lim, Stephen, Mokdad, Ali, Smith, Mari, Gakidou, Emmanuela, Murray, Christopher, and Vos, Theo

42. Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019

Author

Armocida, Benedetta, Monasta, Lorenzo, Sawyer, Susan, Bustreo, Flavia, Segafredo, Giulia, Castelpietra, Giulio, Ronfani, Luca, Pasovic, Maja, Hay, Simon, Perel, Pablo, Beran, David, Sawyer, Susan M., Hay, Simon I., Abila, Derrick Bary, Abolhassani, Hassan, Accrombessi, Manfred Mario Kokou, Adekanmbi, Victor, Ahmadi, Keivan, Al Hamad, Hanadi, Aldeyab, Mamoon A., Al-Jumaily, Adel, Ancuceanu, Robert, Andrei, Catalina Liliana, Andrei, Tudorel, Arumugam, Ashokan, Attia, Sameh, Aujayeb, Avinash, Ausloos, Marcel, Baker, Jennifer L., Barone-Adesi, Francesco, Barra, Fabio, Barteit, Sandra, Basu, Sanjay, Baune, Bernhard T., Béjot, Yannick, Belo, Luis, Bennett, Derrick A., Bikbov, Boris, Bikov, Andras, Blyuss, Oleg, Breitner, Susanne, Brenner, Hermann, Carreras, Giulia, Carvalho, Márcia, Catapano, Alberico L., Chandan, Joht Singh, Charalampous, Periklis, Chen, Simiao, Conde, Joao, Cruz-Martins, Natália, Damiani, Giovanni, Dastiridou, Anna, de la Torre-Luque, Alejandro, Dianatinasab, Mostafa, Dias da Silva, Diana, Douiri, Abdel, Dragioti, Elena, Engelbert Bain, Luchuo, Fagbamigbe, Adeniyi Francis, Fereshtehnejad, Seyed-Mohammad, Ferrara, Pietro, Ferreira de Oliveira, José Miguel P., Ferrero, Simone, Ferro Desideri, Lorenzo, Fischer, Florian, Fonseca, Diogo, Gaewkhiew, Piyada, Gaihre, Santosh, Gallus, Silvano, Gaspar Fonseca, Mariana, Gill, Paramjit, Glasbey, James C., Gorini, Giuseppe, Gupta, Vijai Kumar, Gurara, Mekdes Kondale, Haro, Josep Maria, Hasan, M Tasdik, Havmoeller, Rasmus J., Heibati, Behzad, Hellemons, Merel E., Herteliu, Claudiu, Hussain, Salman, Isola, Gaetano, Johnson, Olatunji, Jonas, Jost B., Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Zubair, Karch, André, Kauppila, Joonas H., Kayode, Gbenga A., Khan, Moien A. B., Khatab, Khaled, Kivimäki, Mika, Klugar, Miloslav, Klugarová, Jitka, Koly, Kamrun Nahar, Koyanagi, Ai, Kurmi, Om P., Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lallukka, Tea, Lamnisos, Demetris, Langguth, Berthold, Larsson, Anders O., Lauriola, Paolo, Lee, Paul H., Leonardi, Matilde, Li, An, Linehan, Christine, López-Bueno, Rubén, Lorkowski, Stefan, Loureiro, Joana A., Lunevicius, Raimundas, Magee, Laura A., Magnani, Francesca Giulia, Majeed, Azeem, Makris, Konstantinos Christos, Mathioudakis, Alexander G., Mathur, Manu Raj, McGrath, John J., Menezes, Ritesh G., Mentis, Alexios-Fotios A., Meretoja, Atte, Mestrovic, Tomislav, Miao Jonasson, Junmei, Miazgowski, Tomasz, Mirica, Andreea, Moccia, Marcello, Mohammed, Shafiu, Molokhia, Mariam, Mondello, Stefania, Mueller, Ulrich Otto, Mulita, Francesk, Munblit, Daniel, Negoi, Ionut, Negoi, Ruxandra Irina, Nena, Evangelia, Noor, Nurulamin M., Nowak, Christoph, Ntaios, George, Nwatah, Vincent Ebuka, Oancea, Bogdan, Oguntade, Ayodipupo Sikiru, Ortiz, Alberto, Otoiu, Adrian, Padron-Monedero, Alicia, Palladino, Raffaele, Pana, Adrian, Panagiotakos, Demosthenes, Panda-Jonas, Songhomitra, Pardhan, Shahina, Patel, Jay, Pedersini, Paolo, Peñalvo, José L., Pensato, Umberto, Pereira, Renato B., Perico, Norberto, Petcu, Ionela-Roxana, Polinder, Suzanne, Postma, Maarten J., Rabiee, Mohammad, Rabiee, Navid, Raggi, Alberto, Rahimzadeh, Shadi, Rawaf, David Laith, Rawaf, Salman, Rehman, Faizan Ur, Remuzzi, Giuseppe, Riad, Abanoub, Rodriguez, Alina, Sacco, Simona, Saeb, Mohammad Reza, Safdarian, Mahdi, Sathian, Brijesh, Sattin, Davide, Saxena, Sonia, Scarmeas, Nikolaos, Schlee, Winfried, Schwendicke, Falk, Shamsizadeh, Morteza, Sharew, Nigussie Tadesse, Shiri, Rahman, Shivalli, Siddharudha, Shivarov, Velizar, Silva, João Pedro, Simpson, Colin R., Skou, Søren T., Socea, Bogdan, Soyiri, Ireneous N., Steiropoulos, Paschalis, Straif, Kurt, Sun, Xiaohui, Tabarés-Seisdedos, Rafael, Thiyagarajan, Arulmani, Topouzis, Fotis, Tovani-Palone, Marcos Roberto, Truelsen, Thomas Clement, Unim, Brigid, Van den Eynde, Jef, Vasankari, Tommi Juhani, Veroux, Massimiliano, Villafaina, Santos, Vinko, Matej, Violante, Francesco S., Volovici, Victor, Wang, Yanzhong, Westerman, Ronny, Yadegarfar, Mohammad Esmaeil, Yaya, Sanni, Zadnik, Vesna, Zumla, Alimuddin, HASH(0x5651c96cd260), Bill & Melinda Gates Foundation, Public Health, Pulmonary Medicine, Neurosurgery, Collaborators, GBD 2019 Europe NCDs in Adolescents, Lacey, BWH, Yaya, S, HUS Neurocenter, Department of Neurosciences, Armocida B., Monasta L., Sawyer S., Bustreo F., Segafredo G., Castelpietra G., Ronfani L., Pasovic M., Hay S., Sawyer S.M., Hay S.I., Abila D.B., Abolhassani H., Accrombessi M.M.K., Adekanmbi V., Ahmadi K., Al Hamad H., Aldeyab M.A., Al-Jumaily A., Ancuceanu R., Andrei C.L., Andrei T., Arumugam A., Attia S., Aujayeb A., Ausloos M., Baker J.L., Barone-Adesi F., Barra F., Barteit S., Basu S., Baune B.T., Bejot Y., Belo L., Bennett D.A., Bikbov B., Bikov A., Blyuss 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Population and Behavioural Science Division, and University of St Andrews. School of Medicine

Subjects
Male, mortality burden, Adolescent, RJ, RJ101, Care, Global Burden of Disease, Life Expectancy, RJ101 Child Health. Child health services, SDG 3 - Good Health and Well-being, RA0421, 3123 Gynaecology and paediatrics, Risk Factors, RA0421 Public health. Hygiene. Preventive Medicine, Developmental and Educational Psychology, Humans, Disabled Persons, Noncommunicable Diseases, Future, Determinants, MCC, Disability, Public Health, Global Health, Social Medicine and Epidemiology, Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019, 3rd-DAS, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, n/a, Health, Pediatrics, Perinatology and Child Health, Female, RA
Abstract

Background:Disability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU. Methods:Estimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member States from 1990 to 2019, three age subgroups (10–14 years, 15–19 years, and 20–24 years), and by sex. Spearman's correlation was conducted between DALY rates for NCDs and the Socio-demographic Index (SDI) of each EU Member State. Findings:In 2019, NCDs accounted for 86·4% (95% uncertainty interval 83·5–88·8) of all YLDs and 38·8% (37·4–39·8) of total deaths in adolescents aged 10–24 years. For NCDs in this age group, neoplasms were the leading causes of both mortality (4·01 [95% uncertainty interval 3·62–4·25] per 100 000 population) and YLLs (281·78 [254·25–298·92] per 100 000 population), whereas mental disorders were the leading cause for YLDs (2039·36 [1432·56–2773·47] per 100 000 population) and DALYs (2040·59 [1433·96–2774·62] per 100 000 population) in all EU Member States, and in all studied age groups. In 2019, among adolescents aged 10–24 years, males had a higher mortality rate per 100 000 population due to NCDs than females (11·66 [11·04–12·28]vs7·89 [7·53–8·23]), whereas females presented a higher DALY rate per 100 000 population due to NCDs (8003·25 [5812·78–10 701·59]vs6083·91 [4576·63–7857·92]). From 1990 to 2019, mortality rate due to NCDs in adolescents aged 10–24 years substantially decreased (–40·41% [–43·00 to –37·61), and also the YLL rate considerably decreased (–40·56% [–43·16 to –37·74]), except for mental disorders (which increased by 32·18% [1·67 to 66·49]), whereas the YLD rate increased slightly (1·44% [0·09 to 2·79]). Positive correlations were observed between DALY rates and SDIs for substance use disorders (rs=0·58, p=0·0012) and skin and subcutaneous diseases (rs=0·45, p=0·017), whereas negative correlations were found between DALY rates and SDIs for cardiovascular diseases (rs=–0·46, p=0·015), neoplasms (rs=–0·57, p=0·0015), and sense organ diseases (rs=–0·61, p=0·0005). Interpretation:NCD-related mortality has substantially declined among adolescents in the EU between 1990 and 2019, but the rising trend of YLL attributed to mental disorders and their YLD burden are concerning. Differences by sex, age group, and across EU Member States highlight the importance of preventive interventions and scaling up adolescent-responsive health-care systems, which should prioritise specific needs by sex, age, and location. Funding: Bill & Melinda Gates Foundation.

Published
2022
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43. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Sorin Hostiuc, Shaun Wen Huey Lee, Jorge R. Ledesma, Carsten Flohr, Masoumeh Sadeghi, João Mauricio Castaldelli-Maia, Behzad Karami Matin, Cyrus Alinia, Mehdi Bohluli, Félix Carvalho, Yun Jin Kim, Catalina Liliana Andrei, Seyyed Meysam Mousavi, Bernhard T. Baune, Ehsan Ahmadpour, Dinh-Toi Chu, Beatrix Haddock, Gianfranco Alicandro, Vasily Vlassov, Mohammad Taghi Khodayari, Gianna Gayle Herrera Amul, Arash Tehrani-Banihashemi, Govinda Prasad Dhungana, Fereshteh Ansari, Michael K. Hole, Azeem Majeed, Iman Halvaei, Saqib Ali, Arianna Maever L. Amit, Tomas Y. Yeheyis, John S. Ji, Martin McKee, Jamileh Shadid, Leonardo Roever, Peng Jia, Ettore Beghi, Pablo M. Lavados, Young Eun Kim, Vahid Alipour, Sowmya J. Rao, Ahmad Daryani, Cathleen Keller, Ibrahim Abdollahpour, Nicole K. DeCleene, Ebrahim Babaee, Saman Esmaeilnejad, Boris Bikbov, William M. Gardner, Lydia M. Haile, Luca Ronfani, Azalea M. Thomson, Irena Ilic, Ruth W. Kimokoti, Yingxi Zhao, Guoqing Hu, Mehran Shams-Beyranvand, Ilais Moreno Velásquez, Nathaniel J. Henry, Brijesh Sathian, Daniel Kim, Peter Memiah, Mohammad Hadi Abbasi, Andrea Farioli, Zahra Kamiab, Bolajoko O. Olusanya, Matthew C. Doxey, Tommi Vasankari, Hamideh Salimzadeh, Luisa Sorio Flor, Priya Rathi, Shanshan Li, Tanvir M. Huda, Dillon O Sylte, Rosario Cárdenas, Agegnehu Bante, Helen Ippolito, Alyssa Acebedo, Jeffrey D. Stanaway, Anwar Faraj, João Pedro Silva, Amin Mousavi Khaneghah, Pushpendra Kumar, Sangram Kishor Patel, Josephine W. Ngunjiri, Holly E. Erskine, Eugene Sobngwi, Filippo Ariani, Shane D. Morrison, Mohammad Aghaali, Meghan D. Mooney, Vera Marisa Costa, Palash Chandra Banik, Rupak Desai, Ken Takahashi, Maigeng Zhou, Morteza Oladnabi, Bogdan Oancea, Daniela Ribeiro, Mohammad Farahmand, Irmina Maria Michalek, Yetunde O. John-Akinola, Khem Narayan Pokhrel, Emilie R Maddison, Syed Mohamed Aljunid, Damian G. Hoy, Hosni Salem, V. 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L., Department of Public Health, Clinicum, Department of Neurosciences, HUS Comprehensive Cancer Center, Environmental Sciences, Public Health, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), Sálfræðideild (HR), Department of Psychology (RU), Samfélagssvið (HR), School of Social Sciences (RU), Háskólinn í Reykjavík, Reykjavik University, GBD 2019 Diseases and Injuries Collaborator, Violante FS, Department of Earth Observation Science, Faculty of Geo-Information Science and Earth Observation, and UT-I-ITC-ACQUAL

Subjects
Male, Life expectancy, Disability-Adjusted Life Year, Diseases, Disease, communicable disease, systematic analysis, Global Burden of Disease, 0302 clinical medicine, 80 and over, Medicine, 10. No inequality, Child, 11 Medical and Health Sciences, injuries, Aged, 80 and over, education.field_of_study, Sjúkdómar, DEMENTIA, FALLS, General Medicine, Forvarnir, 3. Good health, Child, Preschool, Human, GBD, Population health, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Humans, Global Burden of Disease Study, education, Aged, Spatial Analysis, Global burden, Disability, Prevention, DISABILITY, Infant, Spatial Analysi, Mortality rate, Global Burden of Disease, Diseases, Injuries, Systematic analysis, PREVENTION, Years of potential life lost, Risk factors, Disease study, ITC-ISI-JOURNAL-ARTICLE, RISK-FACTORS, Clinical Medicine, RA, Demography, Fötlun, Dánartíðni, Áhættuþættir, 030204 cardiovascular system & hematology, Risk Factors, Cause of Death, Global health, 030212 general & internal medicine, 1. No poverty, Disability-Adjusted Life Years, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, 3142 Public health care science, environmental and occupational health, Adolescent, Adult, Age Distribution, Female, Infant, Newborn, Young Adult, Lýðheilsa, CLINICAL-TRIALS, Population, Settore MED/01 - Statistica Medica, diseases, ITC-HYBRID, Heilbrigðisvísindi, General & Internal Medicine, Mortality, Preschool, Disease burden, business.industry, Risk Factor, Klinisk medicin, Newborn, purl.org/pe-repo/ocde/ford#3.02.00 [https], Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Áverkar, Systematic analysis, NA, business
Abstract

Publisher's version (útgefin grein), Background In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990-2010 time period, with the greatest annualised rate of decline occurring in the 0-9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10-24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10-24 years were also in the top ten in the 25-49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50-74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd., Research reported in this publication was supported by the Bill & Melinda Gates Foundation; the University of Melbourne; Queensland Department of Health, Australia; the National Health and Medical Research Council, Australia; Public Health England; the Norwegian Institute of Public Health; St Jude Children's Research Hospital; the Cardiovascular Medical Research and Education Fund; the National Institute on Ageing of the National Institutes of Health (award P30AG047845); and the National Institute of Mental Health of the National Institutes of Health (award R01MH110163). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders. The authors alone are responsible for the views expressed in this Article and they do not necessarily represent the views, decisions, or policies of the institutions with which they are affiliated, the National Health Service (NHS), the National Institute for Health Research (NIHR), the UK Department of Health and Social Care, or Public Health England; the United States Agency for International Development (USAID), the US Government, or MEASURE Evaluation; or the European Centre for Disease Prevention and Control (ECDC). This research used data from the Chile National Health Survey 2003, 2009-10, and 2016-17. The authors are grateful to the Ministry of Health, the survey copyright owner, for allowing them to have the database. All results of the study are those of the authors and in no way committed to the Ministry. The Costa Rican Longevity and Healthy Aging Study project is a longitudinal study by the University of Costa Rica's Centro Centroamericano de Poblacion and Instituto de Investigaciones en Salud, in collaboration with the University of California at Berkeley. The original pre-1945 cohort was funded by the Wellcome Trust (grant 072406), and the 1945-55 Retirement Cohort was funded by the US National Institute on Aging (grant R01AG031716). The principal investigators are Luis Rosero-Bixby and William H Dow and co-principal investigators are Xinia Fernandez and Gilbert Brenes. The accuracy of the authors' statistical analysis and the findings they report are not the responsibility of ECDC. ECDC is not responsible for conclusions or opinions drawn from the data provided. ECDC is not responsible for the correctness of the data and for data management, data merging and data collation after provision of the data. ECDC shall not be held liable for improper or incorrect use of the data. The Health Behaviour in School-Aged Children (HBSC) study is an international study carried out in collaboration with WHO/EURO. The international coordinator of the 1997-98, 2001-02, 2005-06, and 2009-10 surveys was Candace Currie and the databank manager for the 1997-98 survey was Bente Wold, whereas for the following surveys Oddrun Samdal was the databank manager. A list of principal investigators in each country can be found on the HBSC website. Data used in this paper come from the 2009-10 Ghana Socioeconomic Panel Study Survey, which is a nationally representative survey of more than 5000 households in Ghana. The survey is a joint effort undertaken by the Institute of Statistical, Social and Economic Research (ISSER) at the University of Ghana and the Economic Growth Centre (EGC) at Yale University. It was funded by EGC. ISSER and the EGC are not responsible for the estimations reported by the analysts. The Palestinian Central Bureau of Statistics granted the researchers access to relevant data in accordance with license number SLN2014-3-170, after subjecting data to processing aiming to preserve the confidentiality of individual data in accordance with the General Statistics Law, 2000. The researchers are solely responsible for the conclusions and inferences drawn upon available data. Data for this research was provided by MEASURE Evaluation, funded by USAID. The authors thank the Russia Longitudinal Monitoring Survey, conducted by the National Research University Higher School of Economics and ZAO Demoscope together with Carolina Population Center, University of North Carolina at Chapel Hill and the Institute of Sociology, Russia Academy of Sciences for making data available. This paper uses data from the Bhutan 2014 STEPS survey, implemented by the Ministry of Health with the support of WHO; the Kuwait 2006 and 2014 STEPS surveys, implemented by the Ministry of Health with the support of WHO; the Libya 2009 STEPS survey, implemented by the Secretariat of Health and Environment with the support of WHO; the Malawi 2009 STEPS survey, implemented by Ministry of Health with the support of WHO; and the Moldova 2013 STEPS survey, implemented by the Ministry of Health, the National Bureau of Statistics, and the National Center of Public Health with the support of WHO. This paper uses data from Survey of Health, Ageing and Retirement in Europe (SHARE) Waves 1 (DOI:10.6103/SHARE. w1.700), 2 (10.6103/SHARE.w2.700), 3 (10.6103/SHARE.w3.700), 4 (10.6103/SHARE.w4.700), 5 (10.6103/SHARE.w5.700), 6 (10.6103/SHARE.w6.700), and 7 (10.6103/SHARE.w7.700); see Borsch-Supan and colleagues (2013) for methodological details. The SHARE data collection has been funded by the European Commission through FP5 (QLK6-CT-2001-00360), FP6 (SHARE-I3: RII-CT-2006-062193, COMPARE: CIT5-CT-2005-028857, SHARELIFE: CIT4-CT-2006-028812), FP7 (SHARE-PREP: GA N degrees 211909, SHARE-LEAP: GA N degrees 227822, SHARE M4: GA N degrees 261982) and Horizon 2020 (SHARE-DEV3: GA N degrees 676536, SERISS: GA N degrees 654221) and by DG Employment, Social Affairs & Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the US National Institute on Aging (U01_AG09740-13S2, P01_AG005842, P01_AG08291, P30_AG12815, R21_AG025169, Y1-AG-4553-01, IAG_BSR06-11, OGHA_04-064, HHSN271201300071C), and from various national funding sources is gratefully acknowledged. This study has been realised using the data collected by the Swiss Household Panel, which is based at the Swiss Centre of Expertise in the Social Sciences. The project is financed by the Swiss National Science Foundation. The United States Aging, Demographics, and Memory Study is a supplement to the Health and Retirement Study (HRS), which is sponsored by the National Institute of Aging (grant number NIA U01AG009740). It was conducted jointly by Duke University and the University of Michigan. The HRS is sponsored by the National Institute on Aging (grant number NIA U01AG009740) and is conducted by the University of Michigan. This paper uses data from Add Health, a program project designed by J Richard Udry, Peter S Bearman, and Kathleen Mullan Harris, and funded by a grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 17 other agencies. Special acknowledgment is due to Ronald R Rindfuss and Barbara Entwisle for assistance in the original design. Information on how to obtain the Add Health data files is available on the Add Health website. No direct support was received from grant P01-HD31921 for this analysis. The data reported here have been supplied by the United States Renal Data System. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy or interpretation of the US Government. Collection of data for the Mozambique National Survey on the Causes of Death 2007-08 was made possible by USAID under the terms of cooperative agreement GPO-A-00-08-000_D3-00. This manuscript is based on data collected and shared by the International Vaccine Institute (IVI) from an original study IVI conducted. L G Abreu acknowledges support from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Brazil; finance code 001) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, a Brazilian funding agency). I N Ackerman was supported by a Victorian Health and Medical Research Fellowship awarded by the Victorian Government. O O Adetokunboh acknowledges the South African Department of Science and Innovation and the National Research Foundation. A Agrawal acknowledges the Wellcome Trust DBT India Alliance Senior Fellowship. S M Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. M Ausloos, C Herteliu, and A Pana acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. A Badawi is supported by the Public Health Agency of Canada. D A Bennett was supported by the NIHR Oxford Biomedical Research Centre. R Bourne acknowledges the Brien Holden Vision Institute, University of Heidelberg, Sightsavers, Fred Hollows Foundation, and Thea Foundation. G B Britton and I Moreno Velasquez were supported by the Sistema Nacional de Investigacion, SNI-SENACYT, Panama. R Buchbinder was supported by an Australian National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship. J J Carrero was supported by the Swedish Research Council (2019-01059). F Carvalho acknowledges UID/MULTI/04378/2019 and UID/QUI/50006/2019 support with funding from FCT/MCTES through national funds. A R Chang was supported by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases grant K23 DK106515. V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundacao para a Ciencia e Tecnologia, IP, under the Norma Transitaria DL57/2016/CP1334/CT0006. A Douiri acknowledges support and funding from the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care South London at King's College Hospital NHS Foundation Trust and the Royal College of Physicians, and support from the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. B B Duncan acknowledges grants from the Foundation for the Support of Research of the State of Rio Grande do Sul (IATS and PrInt) and the Brazilian Ministry of Health. H E Erskine is the recipient of an Australian NHMRC Early Career Fellowship grant (APP1137969). A J Ferrari was supported by a NHMRC Early Career Fellowship grant (APP1121516). H E Erskine and A J Ferrari are employed by and A M Mantilla-Herrera and D F Santomauro affiliated with the Queensland Centre for Mental Health Research, which receives core funding from the Queensland Department of Health. M L Ferreira holds an NHMRC Research Fellowship. C Flohr was supported by the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust. M Freitas acknowledges financial support from the EU (European Regional Development Fund [FEDER] funds through COMPETE POCI-01-0145-FEDER-029248) and National Funds (Fundacao para a Ciencia e Tecnologia) through project PTDC/NAN-MAT/29248/2017. A L S Guimaraes acknowledges support from CNPq. C Herteliu was partially supported by a grant co-funded by FEDER through Operational Competitiveness Program (project ID P_40_382). P Hoogar acknowledges Centre for Bio Cultural Studies, Directorate of Research, Manipal Academy of Higher Education and Centre for Holistic Development and Research, Kalaghatagi. F N Hugo acknowledges the Visiting Professorship, PRINT Program, CAPES Foundation, Brazil. B-F Hwang was supported by China Medical University (CMU107-Z-04), Taichung, Taiwan. S M S Islam was funded by a National Heart Foundation Senior Research Fellowship and supported by Deakin University. R Q Ivers was supported by a research fellowship from the National Health and Medical Research Council of Australia. M Jakovljevic acknowledges the Serbian part of this GBD-related contribution was co-funded through Grant OI175014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. P Jeemon was supported by a Clinical and Public Health intermediate fellowship (grant number IA/CPHI/14/1/501497) from the Wellcome Trust-Department of Biotechnology, India Alliance (2015-20). O John is a recipient of UIPA scholarship from University of New South Wales, Sydney. S V Katikireddi acknowledges funding from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_12017/13, MC_UU_12017/15), and the Scottish Government Chief Scientist Office (SPHSU13, SPHSU15). C Kieling is a CNPq researcher and a UK Academy of Medical Sciences Newton Advanced Fellow. Y J Kim was supported by Research Management Office, Xiamen University Malaysia (XMUMRF/2018-C2/ITCM/00010). K Krishan is supported by UGC Centre of Advanced Study awarded to the Department of Anthropology, Panjab University, Chandigarh, India. M Kumar was supported by K43 TW 010716 FIC/NIMH. B Lacey acknowledges support from the NIHR Oxford Biomedical Research Centre and the BHF Centre of Research Excellence, Oxford. J V Lazarus was supported by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III [ISCIII]/ESF, the EU [CP18/00074]). K J Looker thanks the NIHR Health Protection Research Unit in Evaluation of Interventions at the University of Bristol, in partnership with Public Health England, for research support. S Lorkowski was funded by the German Federal Ministry of Education and Research (nutriCARD, grant agreement number 01EA1808A). R A Lyons is supported by Health Data Research UK (HDR-9006), which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, NIHR (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation, and Wellcome Trust. J J McGrath is supported by the Danish National Research Foundation (Niels Bohr Professorship), and the Queensland Health Department (via West Moreton HHS). P T N Memiah acknowledges support from CODESRIA. U O Mueller gratefully acknowledges funding by the German National Cohort Study BMBF grant number 01ER1801D. S Nomura acknowledges the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K10082). A Ortiz was supported by ISCIII PI19/00815, DTS18/00032, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. These funding sources had no role in the writing of the manuscript or the decision to submit it for publication. S B Patten was supported by the Cuthbertson & Fischer Chair in Pediatric Mental Health at the University of Calgary. G C Patton was supported by an aNHMRC Senior Principal Research Fellowship. M R Phillips was supported in part by the National Natural Science Foundation of China (NSFC, number 81371502 and 81761128031). A Raggi, D Sattin, and S Schiavolin were supported by grants from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C Besta, Linea 4-Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). P Rathi and B Unnikrishnan acknowledge Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal. A L P Ribeiro was supported by Brazilian National Research Council, CNPq, and the Minas Gerais State Research Agency, FAPEMIG. D C Ribeiro was supported by The Sir Charles Hercus Health Research Fellowship (#18/111) Health Research Council of New Zealand. D Ribeiro acknowledges financial support from the EU (FEDER funds through the Operational Competitiveness Program; POCI-01-0145-FEDER-029253). P S Sachdev acknowledges funding from the NHMRC of Australia Program Grant. A M Samy was supported by a fellowship from the Egyptian Fulbright Mission Program. M M Santric-Milicevic acknowledges the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract number 175087). R Sarmiento-Suarez received institutional support from Applied and Environmental Sciences University (Bogota, Colombia) and ISCIII (Madrid, Spain). A E Schutte received support from the South African National Research Foundation SARChI Initiative (GUN 86895) and Medical Research Council. S T S Skou is currently funded by a grant from Region Zealand (Exercise First) and a grant from the European Research Council under the EU's Horizon 2020 research and innovation program (grant agreement number 801790). J B Soriano is funded by Centro de Investigacion en Red de Enfermedades Respiratorias, ISCIII. R Tabares-Seisdedos was supported in part by the national grant PI17/00719 from ISCIII-FEDER. N Taveira was partially supported by the European & Developing Countries Clinical Trials Partnership, the EU (LIFE project, reference RIA2016MC-1615). S Tyrovolas was supported by the Foundation for Education and European Culture, the Sara Borrell postdoctoral programme (reference number CD15/00019 from ISCIII-FEDER). S B Zaman received a scholarship from the Australian Government research training programme in support of his academic career., "Peer Reviewed"

Published
2020
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44. Factors associated with time to pharmacotherapy in patients with Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in Central Europe and East Asia.

Author

Hong, Jihyung, Novick, Diego, Maria Haro, Josep, Treuer, Tamas, Montgomery, William, Shenghu Wu, Altin, Murat, and Sutton Haynes, Virginia

Subjects
*ATTENTION-deficit hyperactivity disorder, *DRUG therapy, *SYMPTOMS
Abstract

Objective: ADHD is a neuro-behavioral disorder and one of the most common chronic health problems in school-aged children. While data on the prevalence of ADHD in non-Western countries, Central Europe and East Asia for example, are limited, they suggest that prevalence rates in these regions are similar to those in Western countries. Treatment options for ADHD include both behavioral and pharmacological therapies. Non conventional interventions such as complementary and alternative medicine (e.g. herbal medicine and homeopathy) are also available in some cultures. There is, however, lack of information on treatment practices and treatment decision process for ADHD, particularly in non-Western countries. This study aimed to explore factors associated with time to medication initiation during follow-up among patients who were newly diagnosed with ADHD symptoms and did not initiate pharmacotherapy at baseline in Central Europe and East Asia. Method: Data were taken from a 1-year prospective, observational study that included a total of 1,068 newly diagnosed paediatric patients with ADHD symptoms from eight countries/areas in Central Europe (Czech Republic, Hungary, Romania, Slovakia and Turkey) and East Asia (China, South Korea and Taiwan). This post-hoc analysis included all patients with at least one post-baseline visit (n=977). Clinical severity was measured using the Clinical Global Impression (CGI) scale and the Child Symptom Inventory-4 (CSI-4) Checklist. A Kaplan-Meier survival curve was used to depict the proportion of patients remaining on no medication during follow-up. Cox-regression was employed to explore baseline patient characteristics associated with time to medication initiation during follow-up. Results: Of the 977 patients analyzed, about two-thirds of patients (67%, n=651) initiated pharmacotherapy with/without psychotherapy at baseline. The remaining 316 patients (33%) received psychotherapy (9%), other treatments (e.g. herbal therapy and homeopathy) (8%), or no treatments (17%) at baseline. Of these, 71% (n=231) started pharmacotherapy soon after baseline, with a median time of 44 days. The KM survival curve also confirmed a prompt shift from no medication-to-medication during follow-up. The percentage of patients who remained on no medication at 400 days was 23.4% (KM survival estimate). Having other children living at home was found to be the most important predictor of medication initiation during follow-up (HR=1.47; 95% CI=1.03, 2.10), followed by increased patient age (HR=1.13; 95% CI=1.06, 1.21) and higher clinical severity at baseline (higher CSI-4 scores) (HR=1.02; 95% CI=1.00, 1.04). Conclusion: Pharmacotherapy was fairly common in the treatment of newly diagnosed paediatric patients with ADHD symptoms in Central Europe and East Asia. Although one in three of these patients did not initiate pharmacotherapy at baseline, the majority of them were quickly switched to pharmacotherapy during follow-up. Having other children living at home, older age of the patient, and having higher clinical severity were associated with time to medication initiation. Given the observational design however, the associations found in our study do not imply causal relationships. [ABSTRACT FROM AUTHOR]

Published
2013

45. Family burden related to mental and physical disorders in the world: results from the WHO World Mental Health (WMH) surveys.

Author

Viana, Maria Carmen, Gruber, Michael J., Shahly, Victoria, Alhamzawi, Ali, Alonso, Jordi, Andrade, Laura H., Angermeyer, Matthias C., Benjet, Corina, Bruffaerts, Ronny, Caldas-de-Almeida, Jose Miguel, de Girolamo, Giovanni, de Jonge, Peter, Ferry, Finola, Florescu, Silvia, Gureje, Oye, Maria Haro, Josep, Hinkov, Hristo, Chiyi Hu, Karam, Elie G., and Lépine, Jean-Pierre

Subjects
*MENTAL health, *DISEASE prevalence, *BURDEN of care, *CAREGIVERS, *FAMILY health, *EMBARRASSMENT
Abstract

Objective: To assess prevalence and correlates of family caregiver burdens associated with mental and physical conditions worldwide. Methods: Cross-sectional community surveys asked 43,732 adults residing in 19 countries of the WHO World Mental Health (WMH) Surveys about chronic physical and mental health conditions of first-degree relatives and associated objective (time, financial) and subjective (distress, embarrassment) burdens. Magnitudes and associations of burden are examined by kinship status and family health problem; population-level estimates are provided. Results: Among the 18.9-40.3% of respondents in high, upper-middle, and low/lower-middle income countries with first-degree relatives having serious health problems, 39.0-39.6% reported burden. Among those, 22.9-31.1% devoted time, 10.6-18.8% had financial burden, 23.3-27.1% reported psychological distress, and 6.0-17.2% embarrassment. Mean caregiving hours/week was 12.9-16.5 (83.7-147.9 hours/week/100 people aged 18+). Mean financial burden was 15.1% of median family income in high, 32.2% in upper-middle, and 44.1% in low/lower-middle income countries. A higher burden was reported by women than men, and for care of parents, spouses, and children than siblings. Conclusions: The uncompensated labor of family caregivers is associated with substantial objective and subjective burden worldwide. Given the growing public health importance of the family caregiving system, it is vital to develop effective interventions that support family caregivers. [ABSTRACT FROM AUTHOR]

Published
2013
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47. [Relationship between healthy lifestyle behaviours and subjective wellbeing: an european observational study.]

Author

Mateos-Lardiés AM, López-García P, Morillo D, Olaya B, Tobiasz-Adamczyk B, Koskinen S, Leonardi M, Maria Haro J, Chatterji S, Ayuso-Mateos JL, Cabello M, and Miret M

Subjects
Humans, Spain epidemiology, Exercise, Fruit, Life Style, Healthy Lifestyle, Vegetables
Abstract

Objective: A healthy lifestyle is related to physical and mental health. The aim of this study was to assess whether different healthy lifestyle behaviours are associated with experiential and evaluative well-being., Methods: A total of 10,800 participants from Finland, Poland and Spain were interviewed in 2011-2012. Physical activity, fruit and vegetable consumption, smoking, alcohol use, and sleep quality were self-reported. Life satisfaction was measured with the Cantril Self-Anchoring Striving Scale. Positive and negative affect were assessed using an abbreviated version of the Day Reconstruction Method. Multivariate regression analyses were performed., Results: Healthy lifestyle behaviours (consumption of five or more servings of fruit and vegetables per day, moderate or high physical activity, being a non-daily smoker, and having a good sleep quality) were positively associated with evaluative well-being (ß=0.23 p<0.001; ß=0.16, p<0.001; ß=0.26, p<0.001; ß=0.23, p<0.001, respectively), after controlling for confounding variables such as health and depression. Good sleep quality was related with higher positive affect (ß=0.29, p<0.001), lower negative affect (ß=-0.15, p<0.001) and higher life satisfaction (ß=0.23, p<0.001), after adjusting for those confounding variables., Conclusions: A healthy lifestyle is an important correlate of well-being independently of its effects on health. Healthy lifestyles could be considered when developing strategies to improve not only the physical health, but also the well-being of the population., Competing Interests: Disclosure The authors report no conflicts of interest in this work.

Published
2022

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