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1. Dietary Quality Changes According to the Preceding Maximum Weight: A Longitudinal Analysis in the PREDIMED-Plus Randomized Trial

Author

Cristina Bouzas, Maria del Mar Bibiloni, Silvia Garcia, David Mateos, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Helmut Schröder, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Luís Serra-Majem, Aurora Bueno-Cavanillas, Rafael M. Micó-Pérez, Xavier Pintó, Miguel Delgado-Rodríguez, María Ortíz-Ramos, Andreu Altés-Boronat, Bogdana L. Luca, Lidia Daimiel, Emilio Ros, Carmen Sayon-Orea, Nerea Becerra-Tomás, Ignacio Manuel Gimenez-Alba, Olga Castañer, Itziar Abete, Lucas Tojal-Sierra, Jéssica Pérez-López, Andrea Bernabé-Casanova, Marian Martin-Padillo, Antonio Garcia-Rios, Sara Castro-Barquero, José Carlos Fernández-García, José Manuel Santos-Lozano, Cesar I. Fernandez-Lazaro, Pablo Hernández-Alonso, Carmen Saiz, Maria Dolors Zomeño, Maria Angeles Zulet, Maria C. Belló-Mora, F. Javier Basterra-Gortari, Silvia Canudas, Albert Goday, and Josep A. Tur

Subjects
body image, dietary pattern, maximum weight, Mediterranean diet, PREDIMED-Plus, Nutrition. Foods and food supply, TX341-641
Abstract

One-year dietary quality change according to the preceding maximum weight in a lifestyle intervention program (PREDIMED-Plus trial, 55–75-year-old overweight or obese adults; n = 5695) was assessed. A validated food frequency questionnaire was used to assess dietary intake. A total of 3 groups were made according to the difference between baseline measured weight and lifetime maximum reported weight: (a) participants entering the study at their maximum weight, (b) moderate weight loss maintainers (WLM), and (c) large WLM. Data were analyzed by General Linear Model. All participants improved average lifestyle. Participants entering the study at their maximum weight were the most susceptible to improve significantly their dietary quality, assessed by adherence to Mediterranean diet, DII and both healthful and unhealthful provegetarian patterns. People at maximum weight are the most benefitted in the short term by a weight management program. Long term weight loss efforts may also reduce the effect of a weight management program.

Published
2020
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2. Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study

Author

Cristina Bouzas, Maria del Mar Bibiloni, Alicia Julibert, Miguel Ruiz-Canela, Jordi Salas-Salvadó, Dolores Corella, Maria Dolors Zomeño, Dora Romaguera, Jesús Vioque, Ángel M. Alonso-Gómez, Julia Wärnberg, J. Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Xavier Pintó, Antonio García Ríos, Aurora Bueno-Cavanillas, José J. Gaforio, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín-Sánchez, Josep Vidal, Clotilde Vázquez, Emilio Ros, Cesar Ignacio Fernandez-Lázaro, Nerea Becerra-Tomás, Ignacio Manuel Gimenez-Alba, Julia Muñoz, Marga Morey, Alejandro Oncina-Canovas, Lucas Tojal-Sierra, Jéssica Pérez-López, Itziar Abete, Tamara Casañas-Quintana, Sara Castro-Barquero, M. Rosa Bernal-López, José Manuel Santos-Lozano, Ana Galera, Escarlata Angullo-Martinez, F. Javier Basterra-Gortari, Josep Basora, Carmen Saiz, Olga Castañer, Marian Martín, Leyre Notario-Barandiarán, María C. Belló-Mora, Carmen Sayón-Orea, Jesús García-Gavilán, Albert Goday, and Josep A. Tur

Subjects
body image, mediterranean lifestyle, overweight, obesity, older adults, desired weight loss, Nutrition. Foods and food supply, TX341-641
Abstract

Background. Body weight dissatisfaction is a hindrance to following a healthy lifestyle and it has been associated with weight concerns. Objectives. The aim of this study was to assess the association between the adherence to the Mediterranean lifestyle (diet and exercise) and the desired body weight loss in an adult Mediterranean population with overweight. Methods. Cross-sectional analysis in 6355 participants (3268 men; 3087 women) with metabolic syndrome and BMI (Body mass index) between 27.0 and 40.0 kg/m2 (55–75 years old) from the PREDIMED-Plus trial. Desired weight loss was the percentage of weight that participants wished to lose. It was categorized into four cut-offs of this percentage (Q1: n = 1495; Q2: 10–15%, n = 1804; Q3: n = 1470; Q4: ≥20%, n = 1589). Diet was assessed using a validated food frequency questionnaire and a 17-item Mediterranean diet questionnaire. Physical activity was assessed by the validated Minnesota-REGICOR and the validated Spanish version of the Nurses’ Health Study questionnaire. Results. Participants reporting higher percentages of desired weight loss (Q3 and Q4) were younger, had higher real and perceived BMI and were more likely to have abdominal obesity. Desired weight loss correlated inversely to physical activity (Q1: 2106 MET min/week; Q4: 1585 MET min/week. p < 0.001) and adherence to Mediterranean diet (Q1: 8.7; Q4: 8.3. p < 0.001). Conclusions. In older Mediterranean individuals with weight excess, desired weight loss was inversely associated with Mediterranean lifestyle adherence. Deeply rooted aspects of the MedDiet remained similar across groups. Longitudinal research is advised to be able to establish causality.

Published
2020
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3. Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk

Author

Alicia Julibert, Maria del Mar Bibiloni, Cristina Bouzas, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Maria Dolors Zomeño, Dora Romaguera, Jesús Vioque, Ángel M. Alonso-Gómez, Julia Wärnberg, J. Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Xavier Pintó, José Lopez-Miranda, Laura García-Molina, José Juan Gaforio, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín-Sánchez, Josep Vidal, Clotilde Vázquez, Emili Ros, Estefanía Toledo, Nerea Becerra-Tomás, Olga Pórtoles, Karla A. Pérez-Vega, Miquel Fiol, Laura Torres-Collado, Lucas Tojal-Sierra, Rosa Carabaño-Moral, Itziar Abete, Almudena Sanchez-Villegas, Rosa Casas, María Rosa Bernal-López, José Manuel Santos-Lozano, Ana Galera, Lucía Ugarriza, Miguel Ruiz-Canela, Nancy Babio, Oscar Coltell, Helmut Schröder, Jadwiga Konieczna, Domingo Orozco-Beltrán, Carolina Sorto-Sánchez, Sonia Eguaras, Laura Barrubés, Montserrat Fitó, Josep A. Tur, and PREDIMED-PLUS Investigators

Subjects
fatty acids, dietary fat, fat intake, Mediterranean diet, cardiovascular disease risk, Nutrition. Foods and food supply, TX341-641
Abstract

Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55–75 years old, with overweight/obesity and MetS) in the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial. Methods: Assessment of fat intake (total fat, monounsatured fatty acids: MUFA, polyunsaturated fatty acids: PUFA, saturated fatty acids: SFA, trans-fatty acids: trans-FA, linoleic acid, α-linolenic acid, and ω-3 FA) using a validated food frequency questionnaire, and diet quality using 17-item Mediterranean dietary questionnaire and fat quality index (FQI). Results: Participants in the highest quintile of total dietary fat intake showed lower intake of energy, carbohydrates, protein and fiber, but higher intake of PUFA, MUFA, SFA, TFA, LA, ALA and ω-3 FA. Differences in MetS components were found according to fat intake. Odds (5th vs. 1st quintile): hyperglycemia: 1.3–1.6 times higher for total fat, MUFA, SFA and ω-3 FA intake; low high-density lipoprotein cholesterol (HDL-c): 1.2 higher for LA; hypertriglyceridemia: 0.7 lower for SFA and ω-3 FA intake. Conclusions: Dietary fats played different role on MetS components of high CVD risk patients. Dietary fat intake was associated with higher risk of hyperglycemia.

Published
2019
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4. Validity of the energy-restricted Mediterranean Diet Adherence Screener

Author

Camille Lassale, Josep Vidal, Miguel Ángel Martínez-González, Ana García-Arellano, Aurora Bueno-Cavanillas, Jordi Salas-Salvadó, José J. Gaforio, Francisco J. Tinahones, José López Miranda, Emilio Ros, José V. Sorlí, Maria Dolors Zomeño, Dolores Corella, Julia Wärnberg, Angel M Alonso Gómez, Helmut Schröder, Dora Romaguera, Clotilde Vázquez, PREDIMED-Plus Investigators, Nancy Babio, Olga Castañer, Josep A. Tur, José Lapetra, Montserrat Fitó, J. Alfredo Martínez, Ramon Estruch, Andrés Díaz-López, Pilar Matía-Martín, Lluis Serra-Majem, Lidia Daimiel, Vicente Martín, Jesús Vioque, Xavier Pintó, Miguel Ruiz-Canela, Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, AstraZeneca, Govern de les Illes Balears, Centros de Investigación Biomédica en Red (España), Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (España), and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (España)

Subjects
Blood Glucose, Male, Food intake, Validation study, Mediterranean diet, Energy restriction, Concurrent validity, Blood Pressure, Critical Care and Intensive Care Medicine, Diet, Mediterranean, Diet Surveys, Body Mass Index, Nutrition Policy, Validity, Environmental health, Surveys and Questionnaires, Validation, Medicine, Humans, Mass Screening, Dieta mediterranea, Triglycerides, Aged, Caloric Restriction, Randomized Controlled Trials as Topic, Nutrition and Dietetics, business.industry, Limits of agreement, Construct validity, Reproducibility of Results, Middle Aged, Predimed, Diet, Female, Short screener, Guideline Adherence, Diet, Healthy, Waist Circumference, business, Biomarkers
Abstract

[Background]: Short dietary assessment tools can be useful to estimate food intake and diet quality in large-scale epidemiological studies with time constraints. [Objective]: To determine the concurrent validity of the 17-item energy-restricted Mediterranean Adherence Screener (er-MEDAS) used in the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial and to analyse its capacity to detect 1-year changes in diet and cardiometabolic risk factors. [Methods]: Validation study nested in the PREDIMED-Plus (n = 6760, 55–75 years). Dietary data were collected by the 17-item er-MEDAS and a 143-item validated semiquantitative food frequency questionnaire (FFQ) at baseline and after 1-year intervention. Cardiometabolic risk markers were measured at both time points. A Mediterranean diet (MedDiet) score was derived from both instruments. Concurrent validity was evaluated by Pearson and intra-class correlation coefficients (ICC) and Bland and Altman limits of agreement. Construct validity was evaluated by assessing 1-year changes in FFQ-reported dietary intake and cardiometabolic profile changes in relation to changes in er-MEDAS. [Results]: A moderate to good correlation between the MedDiet score calculated by both measurement instruments was found: r = 0.61 and ICC = 0.60 (both p < 0.001). Agreement of each of the er-MEDAS items ranged from 55.4% to 85.0% with a moderate mean concordance (kappa = 0.41). Between baseline and 1-year follow-up, energy intake measured by the FFQ decreased by 242 kcal, while Mediterranean food consumption increased in participants with the highest increase in the er-MEDAS MedDiet score. An increase in the er-MEDAS MedDiet score ratings was associated with a decrease in BMI, waist circumference, triglycerides, fasting glucose, diastolic blood pressure, and triglycerides/HDL-cholesterol ratio (p < 0.001 for all), and with an increase in HDL-cholesterol (p = 0.006). [Conclusion]: The er-MEDAS shows a modest to good concurrent validity compared with FFQ data. It shows acceptable construct validity, as a greater er-MEDAS score was associated with more favourable dietary and cardiometabolic profiles over time., The PREDIMED-Plus trial was supported by the official funding agency for biomedical research of the Spanish government, ISCIII through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund four coordinated FIS projects led by Jordi Salas-Salvadó and Josep Vidal, including the following projects: PI13/00673, PI13/ 00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/ 00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/ 00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926; the Special Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física cohorte" PREDIMED-Plus grant to Jordi Salas-Salvadó; the Recercaixa grant to Jordi Salas-Salvadó (2013ACUP00194); the European Research Council Advanced Research Grant 2013–2018 (340918) granted to Miguel Ángel Martínez-Gonzalez, grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016, PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant and FEDER funds (CB06/03) to Josep A. Tur; the Astra Zeneca Young Investigators Award in Category of Obesity and Diabetes 2017 to Dora Romaguera; the ‘FOLIUM’ programme within the FUTURMed project from the Fundación Instituto de Investigación Sanitaria Illes Balears (financed by 2017annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands). JR17/00022 contract to Olga Castaner from ISCIII. CIBERobn (Centros de Investigación Biomedica en Red: Obesidad y Nutrición), CIBEResp (Centros de Investigación Biomedica en Red: Epidemiología y Salud Publica) and CIBERdem (Centros de Investigación Biomedica en Red: Diabetes y Enfermedades). J. Salas-Salvadó gratefully acknowledges the financial support provided by the ICREA Academia programme. None of the funding sources took part in the design, collection, analysis, or interpretation of the data; in writing the manuscript; or in the decision to submit the manuscript for publication.

Published
2021

5. Baseline drinking water consumption and changes in body weight and waist circumference at 2-years of follow-up in a senior Mediterranean population

Author

Jordi Salas-Salvadó, Dolores Corella, M. Angeles Zulet, Lluis Serra-Majem, Mariela Nissenshon, Blanca Riquelme-Gallego, Lidia Daimiel, Antoni Palau-Galindo, Laura Torres-Collado, Maria Dolors Zomeño, Josep A. Tur, Xavier Pintó, Jesús Vioque, Nerea Becerra-Tomás, Olga Castañer, Silvia Canudas, Ignacio M. Gimenez-Alba, Nancy Babio, Ana Galera, Cristina Bouzas, Zenaida Vázquez-Ruiz, Helmut Schröder, J. Alfredo Martínez, Aurora Bueno-Cavanillas, Víctor Micó, and Indira Paz-Graniel

Subjects
0301 basic medicine, Male, Weight loss, Aigua d'alimentació, Sugary drinks, Population, European Regional Development Fund, Pes corporal, 030209 endocrinology & metabolism, Feed-water, Critical Care and Intensive Care Medicine, Body weight, Institutional support, Water consumption, Plain water, Body Mass Index, Beverages, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Medicine, media_common.cataloged_instance, Humans, European union, Baseline (configuration management), education, media_common, Aged, Funding Agency, education.field_of_study, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Drinking Water, 1. No poverty, 6. Clean water, 3. Good health, Spain, Central obesity, Alcoholic beverages, Female, Waist Circumference, business, Humanities
Abstract

The PREDIMEDPlus trial was supported by the Spanish government's official funding agency for biomedical research, ISCIII, through the Fondo de Investigacion para la Salud (FIS) and cofunded by European Union ERDF/ESF, "A way to make Europe"/"Investing in your future" (five coordinated FIS projects led by JS-S and JVid, including the following: PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/00728, PI14/01722, PI14/00636, PI14/01206, PI14/01919, PI14/01374, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00366, PI17/00764, PI17/01827, PI17/01441, PI17/01732, PI17/00926, PI19/00309, PI19/01032, PI19/00576, PI19/00017, and PI19/00781) , the Special Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant to JSS, the European Research Council (Advanced Research Grant 2013-2018, 340918) to MAMG, the Recercaixa Grant to JS-S (2013ACUP00194) , a grant from the Generalitat Valenciana (PROMETEO/2017/017) , a SEMER-GEN grant, and funds from the European Regional Development Fund (CB06/03) . Study resulting from the SLT006/17/00246 grant, funded by the Department of Health of the Generalitat de Catalunya by the call "Accio instrumental de programes de recerca orientats en l'ambit de la recerca i la innovacio en salut". We thank the CERCA Programme/Generalitat de Catalunya for institutional support. This publication has been possible with the support of the Ministerio de Ciencia, Innovacion y Universidades (MICINN) (FPU 17/01925) . Jordi SalasSalvado, senior author of this study, is partially supported by ICREA under the ICREA Academia programme. IP-G receives a grant from the Spanish Ministry of Education, Culture and Sports (FPU 17/01925) . Dr. NB-T is supported by a postdoctoral fellowship (Juan de la Cierva-Formacion, FJC2018-036016-I) . I.M GimenezAlba received an FPU grant from the Ministry of Science, Innovation and Universities (reference FPU 18/01703) . C.B. received a Fernando Tarongi Bauza PhD Grant., Background & aims: The association between drinking water consumption and adiposity has been poorly explored. Therefore, we aimed to analyse the associations between the frequency of drinking water consumption and body weight and waist circumference changes in an elderly Mediterranean cohort. Methods: A total of 1832 elderly participants (aged 55e75 years) with metabolic syndrome from the PREDIMED-Plus study with baseline data on drinking water and other beverages assessed by a validated 32-item Spanish fluid-intake questionnaire and with data on body weight (BW) and waist circumference (WC) at 1-year and 2-year were included in these prospective analyses. Multivariable linear regression models were fitted to assess the b-coefficients and 95% confidence interval (CI) for BWand WC changes in terms of categories of baseline drinking water consumption (tap water and bottled water). The theoretical effect on BWand WC of replacing several beverages with drinking water was assessed using mathematical models. Results: The baseline frequency of drinking water consumptionwas inversely associated with 1-year and 2- year changes in BW. b-coefficients (95%CI) across categories ofwater consumption (, Spanish Government European Commission, European Union ERDF/ESF, "A way to make Europe"/"Investing in your future" PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/00728 PI14/01722 PI14/00636 PI14/01206 PI14/01919 PI14/01374 PI16/01873 PI16/01094 PI16/00501 PI16/00533 PI16/00366, Special Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant, European Research Council (ERC), European Commission 340918, Recercaixa Grant 2013ACUP00194, Generalitat Valenciana European Commission PROMETEO/2017/017, SEMER-GEN grant European Commission CB06/03, Department of Health of the Generalitat de Catalunya SLT006/17/00246, Ministerio de Ciencia, Innovacion y Universidades (MICINN) FPU 17/01925, ICREA under the ICREA Academia programme, Spanish Ministry of Education, Culture and Sports FPU 17/01925, Juan de la Cierva-Formacion FJC2018-036016-I, Ministry of Science, Innovation and Universities FPU 18/01703, Fernando Tarongi Bauza PhD Grant, The European Union ERDF/ESF, "A way to make Europe"/"Investing in your future" PI17/00764 PI17/01827 PI17/01441 PI17/01732 PI17/00926 PI19/00309 PI19/01032 PI19/00576 PI19/00017 PI19/00781

Published
2021

6. Physical activity and metabolic syndrome severity among older adults at cardiovascular risk: 1-Year trends

Author

Jose Lopez-Miranda, Sara Castro-Barquero, Jordi Salas-Salvadó, Cristina Bouzas, Helmut Schröder, Francisco J. Tinahones, José Manuel Santos-Lozano, Laura Torres-Collado, PREDIMED-Plus Investigators, Albert Goday, Luis Serra-Majem, Cesar I Fernandez-Lazaro, Ramon Estruch, Maria Dolors Zomeño, Bogdana L Luca, Aurora Bueno-Cavanillas, Rafael M Micó, Dolores Corella, Josep A. Tur, Jessica Pérez-López, Pablo Hernández-Alonso, Miguel Ángel Martínez-González, Maria C Belló-Mora, Antoni Colom, F. Javier Basterra-Gortari, Olga Castañer, José Lapetra, Lidia Daimiel, Carmen Sayón-Orea, Maria del Mar Bibiloni, Jesús Vioque, Silvia Canudas, Antonio Garcia-Rios, J. Alfredo Martínez, Carmen Saiz, Dora Romaguera, Nerea Becerra-Tomás, Rosa Bernal, María Ortíz-Ramos, Lucas Tojal-Sierra, Catalina M. Mascaró, Julia Wärnberg, Maria Angeles Zulet, Xavier Pintó, Emilio Ros, José J. Gaforio, Andreu Altés-Boronat, Ignacio M. Gimenez-Alba, Ángel M. Alonso-Gómez, Laura Gallardo-Alfaro, and Itziar Abete

Subjects
Male, Time Factors, Mediterranean diet, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Overweight, Diet, Mediterranean, Dietary inflammatory index, Severity of Illness Index, Longitudinal Studies, Prospective Studies, Depression (differential diagnoses), Randomized Controlled Trials as Topic, chemistry.chemical_classification, Metabolic Syndrome, Nutrition and Dietetics, Middle Aged, Prognosis, Cardiovascular Diseases, Saturated fatty acid, Female, medicine.symptom, Diet, Healthy, Cardiology and Cardiovascular Medicine, Nutritive Value, Polyunsaturated fatty acid, Risk Assessment, Environmental health, medicine, Humans, Metabolic syndrome severity, Exercise, Aged, Physical activity, business.industry, Fatty acid, Cardiometabolic Risk Factors, Feeding Behavior, Anthropometry, Protective Factors, medicine.disease, Sedentary behavior, Functional Status, chemistry, Spain, Depression risk, Metabolic syndrome, Sedentary Behavior, business, Risk Reduction Behavior
Abstract

Background and aims: Modifiable lifestyle factors, such as physical activity (PA) and Mediterranean diet (MD), decrease metabolic syndrome (MetS). The aim was to assess 1-year changes of leisure-time physical activity (LTPA), sedentary behavior, and diet quality according to MetS severity in older population at high cardiovascular risk. Methods and results: Prospective analysis of 55-75-year-old 4359 overweight/obese participants with MetS (PREDIMED-Plus trial) categorized in tertiles according to 1-year changes of a validated MetS severity score (MetSSS). Anthropometrics, visceral adiposity index, triglycerides and glucose index, dietary nutrient intake, biochemical marker levels, dietary inflammatory index, and depression symptoms were measured. Diet quality was assessed by 17-item MD questionnaire. PAs were self-reported using the Minnesota-REGICOR Short Physical Activity Questionnaire and 30-s chair stand test. Sedentary behaviors were measured using the Spanish version of the Nurses' Health Study questionnaire. After 1-year follow-up, decreasing MetSSS was associated with an anti-inflammatory dietary pattern, high intake of vegetables, fruits, legumes, nuts, whole grain cereals, white fish, and bluefish and low intake of refined cereals, red and processed meat, cookies/sweets, and snacks/ready-to-eat-meals. It resulted in high intake of polyunsaturated fatty acids, omega-3 fatty acids, protein, fiber, vitamins B1, B6, B9, C, D, potassium, magnesium, and phosphorus and low glycemic index and saturated fatty acid, trans fatty acid, and carbohydrates intake. Regarding PA and sedentary behavior, decreasing MetSSS was associated with increased moderate-to-vigorous LTPA, chair stand test, and decreased sedentary and TV-viewing time. Conclusion: Decreasing MetSSS was associated with an anti-inflammatory dietary pattern, high LTPA, high MD adherence, low sedentary time, and low depression risk. 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Published
2021

7. Correction to: Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study

Author

Estefanía Toledo, Pilar Matía-Martín, Jesús Vioque, Nancy Babio, Rebeca Fernández-Carrión, José Lapetra, Edelys Crespo-Oliva, José Manuel Santos-Lozano, Silvia Canudas, Miguel Ruiz-Canela, Vicente Martín Sánchez, Itziar Abete, Eva-María Navarrete-Muñoz, Laura Tomaino, Lidia Daimiel, Maria Dolors Zomeño, Andrés Díaz-López, I. Sarasa, José M Gámez, José M Antonio Garcia-Rios, Luis Serra-Majem, Miguel Ángel Martínez-González, Elena Rayó, Aurora Bueno-Cavanillas, Itziar Salaverria Lete, Antoni Colom, Cristina Gisbert Sellés, Manoli Garcia-de-la-Hera, Rosa Casas, Olga Castañer, Jose Lopez-Miranda, Josep Vidal, Javier Díez-Espino, José Carlos Fernández-García, Ramon Estruch, Dolores Corella, Josep A. Tur, Jordi Salas-Salvadó, Francisco J. Tinahones, E. Ros, Albert Goday, Laura Compañ-Gabucio, Alejando Oncina-Canovas, Raul Martinez-Lacruz, J. Alfredo Martínez, Dora Romaguera, Sandra Martín-Peláez, Xavier Pintó, Montserrat Fitó, Julia Wärnberg, Ana Isabel de Cos Blanco, Ángel M. Alonso-Gómez, Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, International Nut and Dried Fruit Foundation, AstraZeneca, Fundació Institut d'Investigació Sanitària Illes Balears, and Institución Catalana de Investigación y Estudios Avanzados

Subjects
Cardiometabolic risk, medicine.medical_specialty, Folate, Nutrition and Dietetics, GeneralLiterature_INTRODUCTORYANDSURVEY, business.industry, Cross-sectional study, Diabetes, MEDLINE, Medicine (miscellaneous), medicine.disease, Predimed, Cholesterol, Dietary folate, Metabolic syndrome score, Internal medicine, Diabetes mellitus, Medicine, Metabolic syndrome, business
Abstract

[Purpose]: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. [Methods]: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders., [Results]: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead., [Conclusion]: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects., The PREDIMED-Plus trial was supported by grants from the Instituto de Salud Carlos III, co-financed by the Fondo Europeo de Desarrollo Regional-FEDER including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926; the Cohorte PREDIMED-Plus grant; the European Research Council (Advanced Research Grant 2013–2018, 340918) to M.Á.M.-G., the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, and funds from the European Regional Development Fund (CB06/03 and CB12/03), The International Nut & Dried Fruit Council—FESNAD (Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014–2015, No. 201302) [M.A.M.-G.]; the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 [D.R.], EU-COST Action CA16112, Grant of support to research groups no. 35/2011 from the Balearic Islands Government, Grants from Balearic Islands Health Research Institute (IDISBA). This work is partially supported by ICREA under the ICREA Academia programme.

Published
2021

8. Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study

Author

Julia Wärnberg, Manoli Garcia-de-la-Hera, José M Antonio Garcia-Rios, Raul Martinez-Lacruz, J. Alfredo Martínez, Ana Isabel de Cos Blanco, Itziar Abete, Maria Dolors Zomeño, Ángel M. Alonso-Gómez, Nancy Babio, Dolores Corella, Silvia Canudas, Andrés Díaz-López, Laura Compañ-Gabucio, Vicente Martín Sánchez, José Manuel Santos-Lozano, Pilar Matía-Martín, I. Sarasa, José Lapetra, Alejando Oncina-Canovas, Jordi Salas-Salvadó, Josep Vidal, Sandra Martín-Peláez, Cristina Gisbert Sellés, Rosa Casas, Francisco J. Tinahones, Dora Romaguera, E. Ros, Albert Goday, Miguel Ruiz-Canela, Laura Tomaino, Eva-María Navarrete-Muñoz, Josep A. Tur, José M Gámez, Javier Díez-Espino, José Carlos Fernández-García, Ramon Estruch, Montserrat Fitó, Jesús Vioque, Rebeca Fernández-Carrión, Luis Serra-Majem, Itziar Salaverria Lete, Olga Castañer, Xavier Pintó, Miguel Ángel Martínez-González, Antoni Colom, Elena Rayó, Aurora Bueno-Cavanillas, Edelys Crespo-Oliva, Estefanía Toledo, Jose Lopez-Miranda, Lidia Daimiel, Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, International Nut and Dried Fruit Foundation, AstraZeneca, Fundació Institut d'Investigació Sanitària Illes Balears, and Institución Catalana de Investigación y Estudios Avanzados

Subjects
0301 basic medicine, medicine.medical_specialty, Folate, Mediterranean diet, Cross-sectional study, Medicine (miscellaneous), 030209 endocrinology & metabolism, Overweight, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Folic Acid, Metabolic syndrome score, Risk Factors, Diabetes mellitus, Internal medicine, medicine, Humans, Obesity, Aged, Metabolic Syndrome, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Confounding, Diabetes, medicine.disease, Cardiometabolic risk, Blood pressure, Cholesterol, Cross-Sectional Studies, Metabolic syndrome, medicine.symptom, business
Abstract

[Purpose]: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial., [Methods]: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders., [Results]: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead., [Conclusion]: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects., The PREDIMED-Plus trial was supported by grants from the Instituto de Salud Carlos III, co-financed by the Fondo Europeo de Desarrollo Regional-FEDER including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926; the Cohorte PREDIMED-Plus grant; the European Research Council (Advanced Research Grant 2013–2018, 340918) to M.Á.M.-G., the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, and funds from the European Regional Development Fund (CB06/03 and CB12/03), The International Nut & Dried Fruit Council—FESNAD (Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014–2015, No. 201302) [M.A.M.-G.]; the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 [D.R.], EU-COST Action CA16112, Grant of support to research groups no. 35/2011 from the Balearic Islands Government, Grants from Balearic Islands Health Research Institute (IDISBA). This work is partially supported by ICREA under the ICREA Academia programme.

Published
2020

9. Metabolic Syndrome Features and Excess Weight Were Inversely Associated with Nut Consumption after 1-Year Follow-Up in the PREDIMED-Plus Study

Author

Lidia Daimiel, Javier Basterra-Gortari, Cesar I Fernandez-Lazaro, Ignacio M. Gimenez-Alba, Sara Castro-Barquero, José Lapetra, Maria C Belló-Mora, PREDIMED-Plus Investigators, Clotilde Vázquez, Manuela Abbate, Naomi Cano-Ibáñez, Lluis Serra-Majem, Maria Dolors Zomeño, Jesús Vioque, Jessica Pérez-López, Antonio Garcia-Rios, Laura Gallardo-Alfaro, Montse Fitó, Emilio Ros, Alicia Julibert, Xavier Pintó, Julia Wärnberg, Maria Angeles Zulet, Olga Castañer, Maria del Mar Bibiloni, José Manuel Santos-Lozano, Lucas Tojal-Sierra, Leyre Notario-Barandiaran, Jose Lopez-Miranda, Ramon Estruch, Miguel Ángel Martínez-González, Antoni Colom, José J. Gaforio, Rosa Bernal, Nerea Becerra-Tomás, Ángel M. Alonso-Gómez, Itziar Abete, Josep Vidal, Vicente Martín-Sánchez, Dora Romaguera, Carmen Saiz, Carmen Sayón-Orea, Dolores Corella, Pablo Hernández-Alonso, Pilar Matía-Martín, J. Alfredo Martínez, Jordi Salas-Salvadó, Francisco J. Tinahones, Albert Goday, Josep A. Tur, Silvia Canudas, Instituto de Salud Carlos III, European Commission, European Research Council, Govern de les Illes Balears, Generalitat Valenciana, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), and Ministerio de Educación, Cultura y Deporte (España)

Subjects
0301 basic medicine, Nut, Male, overweight, medicine.medical_specialty, Mediterranean diet, Medicine (miscellaneous), 030209 endocrinology & metabolism, nut consumption, Overweight, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Nuts, obesity, Aged, metabolic syndrome, 2. Zero hunger, Metabolic Syndrome, 030109 nutrition & dietetics, Nutrition and Dietetics, 9. Industry and infrastructure, business.industry, digestive, oral, and skin physiology, food and beverages, Middle Aged, medicine.disease, Obesity, 3. Good health, Diet, Blood pressure, Cohort, excess weight, lifestyle, PREDIMED-Plus study, features of metabolic syndrome, Female, Metabolic syndrome, medicine.symptom, business, older adults, Cohort study, Follow-Up Studies
Abstract

PREDIMED-PLUS investigators: et al., [Background]: High nut consumption has been previously associated with decreased prevalence of metabolic syndrome (MetS) regardless of race and dietary patterns., [Objectives]: The aim of this study was to assess whether changes in nut consumption over a 1-y follow-up are associated with changes in features of MetS in a middle-aged and older Spanish population at high cardiovascular disease risk., [Methods]: This prospective 1-y follow-up cohort study, conducted in the framework of the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial, included 5800 men and women (55–75 y old) with overweight/obesity [BMI (in kg/m2) ≥27 and, [Results]: As nut consumption increased, between each tertile there was a significant decrease in WC, TG, systolic blood pressure, weight, and BMI (P < 0.05), and a significant increase in HDL cholesterol (only in women, P = 0.044). The interaction effect between time and group was significant for total energy intake (P < 0.001), adherence to the Mediterranean diet (MedDiet) (P < 0.001), and nut consumption (P < 0.001). Across tertiles of increasing nut consumption there was a significant increase in extra virgin olive oil intake and adherence to the MedDiet; change in energy intake, on the other hand, was inversely related to consumption of nuts., [Conclusions]: Features of MetS and excess weight were inversely associated with nut consumption after a 1-y follow-up in the PREDIMED-Plus study cohort. This trial was registered at isrctn.com as ISRCTN89898870., The PREDIMED-Plus trial was supported by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is cofunded by the European Regional Development Fund (5 coordinated FIS projects led by JS-S and J Vidal, including projects PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, and PI19/01332); the Special Action Project entitled Implementación y evaluación de una intervención intensive sobre la actividad física Cohorte PREDIMED-Plus grant (to JS-S); European Research Council Advanced Research Grant 2013–2018, 340918 (to MÁM-G); Recercaixa Grant 2013ACUP00194 (to JS-S); Consejería de Salud de la Junta de Andalucía grants PI0458/2013, PS0358/2016, and PI0137/2018; Generalitat Valenciana grant PROMETEO/2017/017; a SEMERGEN grant; EU-COST Action CA16112; Balearic Islands Government grant of support to research groups 35/2011; Balearic Islands Health Research Institute (IdISBa) grants; European Regional Development Fund funds CIBEROBN CB06/03 and CB12/03; and European Commission fund EAT2BENICE_H2020_SFS2016. PH-A is supported by Juan de la Cierva-Formación postdoctoral fellowship FJCI-2017-32205. AC is supported by IdISBa “TECH” fellowship TECH18/03, funded by the 2018 Sustainable Tourism Tax annual plan. LG-A is supported by a FPU PhD program from the Spanish Ministry of Education.

Published
2020

10. Leisure-Time physical activity, sedentary behaviour and diet quality are associated with metabolic syndrome severity: the PREDIMED-Plus Study

Author

Carmen Sayón-Orea, Aurora Bueno-Cavanillas, José Lapetra, Nerea Becerra-Tomás, Carolina Sorto-Sánchez, Maria del Mar Bibiloni, Josep Basora, José Carlos Fernández-García, Ramon Estruch, Dolores Corella, Julia Wärnberg, Jordi Salas-Salvadó, Carmen Saiz, Clotilde Vázquez, Josep Vidal, Xavier Pintó, Pilar Matía-Martín, Ana María Gómez-Pérez, Júlia Muñoz-Martínez, Lucas Tojal-Sierra, Aina M. Galmes-Panades, M. Angeles Zulet, José Manuel Santos-Lozano, José J. Gaforio, Catalina M. Mascaró, Ángel M. Alonso-Gómez, Josep A. Tur, Jadwiga Konieczna, Ana Galera, Lidia Daimiel, Sofía Montemayor, Laura Compañ-Gabucio, Cesar I Fernandez-Lazaro, Ignacio M. Gimenez-Alba, Miguel Ruiz-Canela, Karla Alejandra Pérez-Vega, Tamara Casañas-Quintana, Jesús García-Gavilán, Jesús Vioque, J. Alfredo Martínez, Lluis Serra-Majem, F. Javier Basterra-Gortari, Laura Gallardo-Alfaro, Dora Romaguera, Rafael M. Micó-Pérez, Maria Dolors Zomeño, Jessica Pérez-López, Emilio Ros, Cristina Tercero-Maciá, Montserrat Fitó, Antonio García Ríos, and Sara Castro-Barquero

Subjects
Male, Síndrome metabòlica, Mediterranean diet, humanos, ejercicio físico, 030204 cardiovascular system & hematology, Overweight, Severity of Illness Index, law.invention, chemistry.chemical_compound, 0302 clinical medicine, Sedentarisme, Randomized controlled trial, law, 030212 general & internal medicine, Depression (differential diagnoses), mediana edad, 2. Zero hunger, Metabolic Syndrome, anciano, Nutrition and Dietetics, 4. Education, Middle Aged, 16. Peace & justice, Metabolic syndrome, 3. Good health, Female, medicine.symptom, lcsh:Nutrition. Foods and food supply, medicine.medical_specialty, lcsh:TX341-641, Article, 03 medical and health sciences, Food Preferences, Mediterranean cooking, Leisure Activities, Internal medicine, Cuina mediterrània, medicine, ingesta energética, Humans, índice de gravedad de la enfermedad, Exercise, Metabolic syndrome severity, Aged, business.industry, Cholesterol, Physical activity, actividades de ocio, Sedentary behaviour, Anthropometry, Physical fitness, medicine.disease, Obesity, preferencias alimenticias, Sedentary behavior, Cross-Sectional Studies, chemistry, Depression risk, Sedentary Behavior, business, Energy Intake, Food Science, estudios transversales, Condició física
Abstract

The authors especially thank the PREDIMED-Plus participants for their enthusiastic collaboration, the PREDIMED-Plus personnel for outstanding support, and the personnel of all associated primary care centres for their exceptional effort. CIBEROBN, CIBERESP and CIBERDEM are initiatives of Instituto de Salud Carlos III, Spain. We thank the PREDIMED-Plus Biobank Network, part of the National Biobank Platform of Instituto de Salud Carlos III for storing and managing biological samples., Healthy lifestyle factors, such as physical activity (PA) and Mediterranean diet (MD), decrease the likelihood of developing metabolic syndrome (MetS). The aim of this study was to report main lifestyle components and related factors according to the MetS severity. Cross-sectional analysis was done of baseline lifestyle factors from 5739 participants with overweight/obesity and MetS features (aged 55–75 years) included in the PREDIMED-PLUS primary cardiovascular prevention randomized trial. Participants were categorized in tertiles according to a validated MetS severity score (MetSSS). Anthropometrics, visceral adiposity index, dietary nutrient intake, biochemical marker levels, as well as a Dietary Inflammatory Index and depression symptoms (Beck Depression Inventory-II) were measured. Diet quality was assessed using a 17-item energy-restricted MD questionnaire. Duration and intensity of PA was self-reported using the Minnesota-REGICOR Short Physical Activity Questionnaire. Sedentary behaviours were measured using the Spanish version of the Nurses’ Health Study questionnaire. The 30 s chair stand test was also assessed. Participants with highest MetSSS showed higher values of cardiovascular risk factors (except for total cholesterol and LDL cholesterol), depression risk, sedentary and TV viewing time, and lower moderate and vigorous leisure-time physical activity (LTPA). Highest MetSSS participants tended to a pro-inflammatory dietary pattern and tended to lower MD adherence. In addition, they showed lower carbohydrate and nut intake and higher intake of protein, saturated and trans fatty acids, cholesterol, iodine, sodium, red and processed meat products, other oils different from olive oil and spirit alcoholic drinks. The highest MetS severity score was associated with lower moderate and vigorous LTPA and higher sedentary time and depression risk, as they tended to a pro-inflammatory dietary pattern and lower MD adherence., The PREDIMED-Plus trial was supported by the official funding agency for biomedical research of the Spanish government, ISCIII, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund [five coordinated FIS projects led by Jordi Salas-Salvadó and Josep Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, and PI19/01332], the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to Jordi Salas-Salvadó, the European Research Council (Advanced Research Grant 2014–2019, 340918) to Dr. Miguel A. Martínez-González, the Recercaixa Grant to Jordi Salas-Salvadó (2013ACUP00194), Grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a Grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN Grant, EU-COST Action CA16112, a Grant of support to research groups no. 35/2011 from the Balearic Islands Government, Grants from Balearic Islands Health Research Institute IDISBA [FOLIUM, PRIMUS, SYNERGIA, and LIBERI], funds from the European Regional Development Fund (CIBEROBN CB06/03 and CB12/03) and from the European Commission (EAT2BENICE_H2020_SFS2016). Fundació La Marató TV3 (projects no. PI044003 and 201630.10). Laura Gallardo-Alfaro and Catalina M. Mascaró received FPU PhD Grants from the Spanish Ministry of Education. The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data; in the writing of the manuscript, and in the decision to publish the results.

Published
2020

11. Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study

Author

Josep A. Tur, Itziar Abete, José J. Gaforio, Jordi Salas-Salvadó, Nerea Becerra-Tomás, Francisco J. Tinahones, Albert Goday, Xavier Pintó, Maria Dolors Zomeño, Julia Wärnberg, Alejandro Oncina-Canovas, Carmen Saiz, Jessica Pérez-López, Dolores Corella, Clotilde Vázquez, Lucas Tojal-Sierra, Leyre Notario-Barandiaran, Marga Morey, Lidia Daimiel, Aurora Bueno-Cavanillas, José Manuel Santos-Lozano, José Lapetra, F. Javier Basterra-Gortari, Julia Muñoz, Alicia Julibert, Marian Martín, M. Rosa Bernal-Lopez, Sara Castro-Barquero, Ana Galera, Josep Vidal, Vicente Martín-Sánchez, Miguel Ruiz-Canela, Maria C Belló-Mora, Emilio Ros, Ignacio M. Gimenez-Alba, Antonio García Ríos, Tamara Casañas-Quintana, Ángel M. Alonso-Gómez, Jesús García-Gavilán, Josep Basora, Jesús Vioque, Ramon Estruch, Dora Romaguera, Luis Serra-Majem, Cesar I Fernandez-Lazaro, Pilar Matía-Martín, Escarlata Angullo-Martinez, Cristina Bouzas, Carmen Sayón-Orea, J. Alfredo Martínez, Olga Castañer, Maria del Mar Bibiloni, [Bouzas,C, Bibiloni,MM, Julibert,A, Ruiz-Canela,M, Salas-Salvadó,J, Corella,D, Zomeño,MD, Romaguera,D, Alonso-Gómez,ÁM, Wärnberg,J, Martínez,JA, Serra-Majem,L, Estruch,R, Tinahones,FJ, Lapetra,J, Pintó,X, García Ríos,A, Vázquez,C, Ros,E, Fernandez-Lázaro,CI, Becerra-Tomás,N, Gimenez-Alba,IM, Muñoz,J, Morey,M, Pérez-López,J, Abete,I, Casañas-Quintana,T, Castro-Barquero,S, Bernal-López,MR, Santos-Lozano,JM, Galera,A, Angullo-Martinez,E, Basterra-Gortari,FJ, Basora,J, Saiz,C, Castañer,O, Martín,M, Belló-Mora,MC, Sayón-Orea,C, García-Gavilán,J, Goday,A, Tur,JA] CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Bouzas,C, Tojal-Sierra,L, Tur,JA] Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, Guillem Colom Bldg, Campus, Palma de Mallorca, Spain. [Bouzas,C, Tur,JA] Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain. [Ruiz-Canela,M, Sayón-Orea,C] Department of Preventive Medicine and Public Health, IdISNA, University of Navarra, Pamplona, Spain. [Salas-Salvadó,J, García-Gavilán,J] Universitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Reus, Spain. [Salas-Salvadó,J] Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain. [Corella,D, Saiz,C] Department of Preventive Medicine, University of Valencia, Valencia, Spain. [Zomeño,MD, Goday,A] Unit of Cardiovascular Risk and Nutrition, Institut Hospital del Mar de Investigaciones Médicas Municipal d’Investigació Mèdica (IMIM), Barcelona, Spain. [Zomeño,MD] Blanquerna School of Health Sciences, Universitat Ramon Llull, Barcelona, Spain. [Vioque,J, Oncina-Canovas,A, Notario-Barandiarán,L] Unit of Nutritional Epidemiology, Miguel Hernández University, ISABIAL-UMH, Alicante, Spain. [Vioque,J, Bueno-Cavanillas,A, Gaforio,JJ, Notario-Barandiarán,L] CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Alonso-Gómez,ÁM, Belló-Mora,MC] Bioaraba Health Research Institute, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain. [Wärnberg,J, Pérez-López,J] Department of Nursing, School of Health Sciences, University of Málaga-IBIMA, Málaga, Spain. [Martínez,JA] Precision Nutrition Program, IMDEA Food, CEI UAM + CSIC, Madrid, Spain. [Martínez,JA, Abete,I] Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain. [Serra-Majem,L, Casañas-Quintana,T] Institute for Biomedical Research, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. [Estruch,R, Castro-Barquero,S] Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain. [Tinahones,FJ, Bernal-López,MR] Virgen de la Victoria Hospital, Department of Endocrinology, Biomedical Research Institute of Málaga (IBIMA), University of Málaga, Málaga, Spain. [Lapetra,J, Santos-Lozano,JM] Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain. [Pintó,X, Galera,A] Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain. [García Ríos,A] Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain. [Bueno-Cavanillas,A] Department of Preventive Medicine, University of Granada, Granada, Spain. [Gaforio,JJ] Department of Health Sciences, Centro de Estudios Avanzados en Olivar y Aceites de Oliva, University of Jaen, Jaen, Spain. [Matía-Martín,P] Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Daimiel,L] Nutritional Genomics and Epigenomics Group, IMDEA Food, CEI UAM + CSIC, Madrid, Spain. [Martín-Sánchez,V] CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Martín-Sánchez,V] Institute of Biomedicine (IBIOMED), University of León, León, Spain. [Vidal,J] Department of Endocrinology, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain. [Vázquez,C] Department of Endocrinology, Fundación Jiménez-Díaz, Madrid, Spain. [Ros,E] Lipid Clinic, Department of Endocrinology and Nutrition, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain. [Angullo-Martinez,E] Escola Graduada Primary Health Care Center, IBSalut, Palma de Mallorca, Spain. [Basterra-Gortari,FJ, Sayón-Orea,C] Servicio Navarro de Salud, Osasunbidea, Pamplona, Spain., The PREDIMED-Plus trial was supported by the official funding agency for biomedical research of the Spanish government, ISCIII, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (five coordinated FIS projects led by J.S.-S. and J.Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, and PI19/01332, the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., the European Research Council (Advanced Research Grant 2013–2018, 340918) to Miguel Ángel Martínez-González, the Recercaixa Grant to J.S.-S. (2013ACUP00194), Grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a Grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN Grant, EU-COST Action CA16112, a Grant of support to research groups no. 35/2011 from the Balearic Islands Government, Grants from Balearic Islands Health Research Institute (IDISBA), funds from the European Regional Development Fund (CIBEROBN CB06/03 and CB12/03) and from the European Commission (EAT2BENICE_H2020_SFS2016). M. Rosa Bernal-López was supported by 'Miguel Servet Type I' program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the European Regional Development Fund. Jordi Salas-Salvadó is partially supported by ICREA under the ICREA Academia programme. Cristina Bouzas received a Fernando Tarongí Bauzà PhD Grant. I.M Gimenez-Alba received a grant FPU from the Ministry of Science, Innovation and Univesities (reference FPU 18/01703). The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data, and in the writing of the manuscript, and in the decision to publish the results.

Subjects
Male, Mediterranean diet, Obesidad, ejercicio físico, Body Mass Index, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Surveys and Questionnaires, Antineoplastic Combined Chemotherapy Protocols, Medicine, mediana edad, education.field_of_study, anciano, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Age Factors [Medical Subject Headings], dieta, protocolos de quimioterapia antineoplásica combinada, 3. Good health, Older adults, metotrexato, programas de reducción de peso, Obesitat, lcsh:Nutrition. Foods and food supply, Personas mayores frágiles, Ideal weight, Lifestyles, Check Tags::Male [Medical Subject Headings], lcsh:TX341-641, Article, Estilo de vida, 03 medical and health sciences, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight [Medical Subject Headings], Anthropology, Education, Sociology and Social Phenomena::Human Activities::Exercise [Medical Subject Headings], ifosfamida, Humans, cisplatino, Ifosfamide, education, Exercise, Aged, conducta alimentaria, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome X [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style [Medical Subject Headings], PREDIMED-Plus, medicine.disease, Obesity, Methotrexate, Check Tags::Female [Medical Subject Headings], Desired weight loss, Metabolic syndrome, Cisplatin, Body mass index, Demography, obesity, cumplimiento del paciente, humanos, Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings], Ideal Body Weight, desired weight loss, Health Care::Health Care Facilities, Manpower, and Services::Health Promotion::Weight Reduction Programs [Medical Subject Headings], Overweight, Diet, Mediterranean, Mediterranean lifestyle, Health Care::Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Health Promotion::Healthy People Programs [Medical Subject Headings], Weight loss, 030212 general & internal medicine, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Health Behavior::Patient Compliance [Medical Subject Headings], Abdominal obesity, older adults, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], 2. Zero hunger, Nutrition and Dietetics, mediterranean lifestyle, sobrepeso, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet, Mediterranean [Medical Subject Headings], Age Factors, ideal weight, Middle Aged, Peso corporal ideal, Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Ideal Body Weight [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Weight Reduction Programs, Body image, Female, medicine.symptom, peso corporal ideal, Estils de vida, doxorrubicina, body image, Population, Imagen corporal, 030209 endocrinology & metabolism, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior [Medical Subject Headings], overweight, Healthy Lifestyle, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, índice de masa corporal, Feeding Behavior, Dieta mediterránea, Diet, Doxorubicin, Sobrepeso, Patient Compliance, Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Perception::Body Image [Medical Subject Headings], business, Food Science
Abstract

Background. Body weight dissatisfaction is a hindrance to following a healthy lifestyle and it has been associated with weight concerns. Objectives. The aim of this study was to assess the association between the adherence to the Mediterranean lifestyle (diet and exercise) and the desired body weight loss in an adult Mediterranean population with overweight. Methods. Cross-sectional analysis in 6355 participants (3268 men; 3087 women) with metabolic syndrome and BMI (Body mass index) between 27.0 and 40.0 kg/m2 (55–75 years old) from the PREDIMED-Plus trial. Desired weight loss was the percentage of weight that participants wished to lose. It was categorized into four cut-offs of this percentage (Q1, European Research Council (ERC) 340918, Recercaixa Grant 2013ACUP00194, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, Generalitat Valenciana PROMETEO/2017/017, SEMERGEN Grant, European Union (EU) European Cooperation in Science and Technology (COST) CA16112, Balearic Islands Government 35/2011, Balearic Islands Health Research Institute (IDISBA), European Union (EU) CIBEROBN CB06/03 CB12/03 PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056, European Commission Joint Research Centre EAT2BENICE_H2020_SFS2016, "Miguel Servet Type I" program from the ISCIII-Madrid (Spain) CP15/00028, ICREA under the ICREA Academia programme, Fernando Tarongi Bauza PhD Grant, FPU from the Ministry of Science, Innovation and Univesities FPU 18/01703, Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS), Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332

Published
2020

12. Dietary Quality Changes According to the Preceding Maximum Weight: A Longitudinal Analysis in the PREDIMED-Plus Randomized Trial

Author

Aurora Bueno-Cavanillas, Jose Lopez-Miranda, Miguel Delgado-Rodríguez, Maria del Mar Bibiloni, David Mateos, Helmut Schröder, Emilio Ros, José Carlos Fernández-García, Ramon Estruch, José Lapetra, Andrea Bernabé-Casanova, Andreu Altés-Boronat, Itziar Abete, Dora Romaguera, Lidia Daimiel, Bogdana L. Luca, Carmen Saiz, Ignacio M. Gimenez-Alba, Jesús Vioque, Silvia Moreno García, Ángel M. Alonso-Gómez, Marian Martin-Padillo, Julia Wärnberg, María Ortíz-Ramos, Nerea Becerra-Tomás, Silvia Canudas, Luis Serra-Majem, Cesar I Fernandez-Lazaro, Maria Angeles Zulet, Cristina Bouzas, F. Javier Basterra-Gortari, Maria C Belló-Mora, Pablo Hernández-Alonso, J. Alfredo Martínez, José Manuel Santos-Lozano, Dolores Corella, Carmen Sayón-Orea, Olga Castañer, Rafael M. Micó-Pérez, Xavier Pintó, Maria Dolors Zomeño, Jessica Pérez-López, Jordi Salas-Salvadó, Francisco J. Tinahones, Albert Goday, Sara Castro-Barquero, Miguel Ángel Martínez-González, Josep A. Tur, Antonio Garcia-Rios, and Lucas Tojal-Sierra

Subjects
Male, cumplimiento del paciente, Mediterranean diet, humanos, Overweight, Diet, Mediterranean, law.invention, encuestas sobre dietas, Clinical trials, 0302 clinical medicine, Randomized controlled trial, Behavior Therapy, Weight loss, law, estudios prospectivos, Weight management, Medicine, Longitudinal Studies, Prospective Studies, 030212 general & internal medicine, skin and connective tissue diseases, mediana edad, anciano, Nutrition and Dietetics, sobrepeso, dieta, resultado del tratamiento, Maximum weight, modelos lineales, Middle Aged, Weight Reduction Programs, Treatment Outcome, Body image, Diet quality, Cardiovascular Diseases, estilo de vida, programas de reducción de peso, Female, Dieta, terapia conductista, dietary pattern, Diet, Healthy, pérdida de peso, medicine.symptom, maximum weight, lcsh:Nutrition. Foods and food supply, body image, enfermedades cardiovasculares, Pes corporal, Dietary pattern, lcsh:TX341-641, 030209 endocrinology & metabolism, Diet Surveys, Article, 03 medical and health sciences, Weight Loss, Humans, Obesity, Life Style, obesidad, Aged, General linear model, business.industry, PREDIMED-Plus, Body weight, Predimed, Diet, Linear Models, Patient Compliance, estudios longitudinales, Body-Weight Trajectory, sense organs, business, Assaigs clínics, Food Science, Demography
Abstract

One-year dietary quality change according to the preceding maximum weight in a lifestyle intervention program (PREDIMED-Plus trial, 55–75-year-old overweight or obese adults; n = 5695) was assessed. A validated food frequency questionnaire was used to assess dietary intake. A total of 3 groups were made according to the difference between baseline measured weight and lifetime maximum reported weight: (a) participants entering the study at their maximum weight, (b) moderate weight loss maintainers (WLM), and (c) large WLM. Data were analyzed by General Linear Model. All participants improved average lifestyle. Participants entering the study at their maximum weight were the most susceptible to improve significantly their dietary quality, assessed by adherence to Mediterranean diet, DII and both healthful and unhealthful provegetarian patterns. People at maximum weight are the most benefitted in the short term by a weight management program. Long term weight loss efforts may also reduce the effect of a weight management program., European Research Council (ERC) 340918, Official funding agency for biomedical research of the Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS), Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensive sobre la actividad fisica Cohorte PREDIMED-Plus grant, Recercaixa Grant 2013ACUP00194, Generalitat Valenciana PROMETEO/2017/017, SEMERGEN Grant, European Union (EU) European Cooperation in Science and Technology (COST) CA16112, Balearic Islands Government 35/2011, Balearic Islands Health Research Institute (IDISBA), European Union (EU) CIBEROBN CB06/03 CB12/03 PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206 PI14/01919 PI14/00853 PI14/01374 PI14/00972 PI14/00728, European Commission European Commission Joint Research Centre EAT2BENICE_H2020_SFS2016, Fernando Tarongi Bauza Grant, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI14/01471, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332

Published
2020
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13. Total and Subtypes of Dietary Fat Intake and its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk

Author

Nerea Becerra-Tomás, Pilar Matía-Martín, María Rosa Bernal-López, José Lapetra, Miquel Fiol, Josep A. Tur, Dolores Corella, Miguel Ángel Martínez-González, José J. Gaforio, Lucas Tojal-Sierra, Almudena Sánchez-Villegas, Josep Vidal, Maria Dolors Zomeño, Cristina Bouzas, Helmut Schröder, Estefanía Toledo, Vicente Martín-Sánchez, Itziar Abete, PREDIMED-Plus Investigators, Jordi Salas-Salvadó, Rosa Casas, J. Alfredo Martínez, Alicia Julibert, Nancy Babio, Carolina Sorto-Sánchez, Jose Lopez-Miranda, Francisco J. Tinahones, Olga Portolés, E. Ros, Karla Alejandra Pérez-Vega, Laura García-Molina, Sonia Eguaras, Montserrat Fitó, Xavier Pintó, Julia Wärnberg, Laura Barrubés, Dora Romaguera, Lidia Daimiel, Maria del Mar Bibiloni, Ana Galera, Domingo Orozco-Beltrán, Laura Torres-Collado, Rosa Carabaño-Moral, Ramon Estruch, Jesús Vioque, Oscar Coltell, Miguel Ruiz-Canela, Luis Serra-Majem, Lucía Ugarriza, José Manuel Santos-Lozano, Clotilde Vázquez, Jadwiga Konieczna, and Ángel M. Alonso-Gómez

Subjects
Blood Glucose, Male, Mediterranean diet, humanos, Physiology, Àcids grassos, 030204 cardiovascular system & hematology, Overweight, Diet, Mediterranean, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, evaluación de riesgos, Medicine, 030212 general & internal medicine, mediana edad, lípidos, 2. Zero hunger, chemistry.chemical_classification, Metabolic Syndrome, education.field_of_study, anciano, Nutrition and Dietetics, dieta, resultado del tratamiento, food and beverages, Middle Aged, Lipids, cardiovascular disease risk, 3. Good health, fat intake, Treatment Outcome, Cardiovascular Diseases, dietary fat, Obesitat, Female, medicine.symptom, lcsh:Nutrition. Foods and food supply, Polyunsaturated fatty acid, glucosa sanguínea, Mediterranean diet, cardiovascular disease risk, dietary fat, fat intake, fatty acids, Linoleic acid, Population, dislipidemias, enfermedades cardiovasculares, lcsh:TX341-641, Risk Assessment, fatty acids, Article, 03 medical and health sciences, grasas dietéticas, Mediterranean cooking, Ciencias de la Salud::Medicina preventiva [Materias Investigacion], Cuina mediterrània, factores de riesgo, Humans, Obesity, cardiovascular diseases, education, hiperglucemia, Aged, Dyslipidemias, business.industry, Malalties cardiovasculars, Hypertriglyceridemia, medicine.disease, Dietary Fats, Diet, Cross-Sectional Studies, chemistry, Spain, Hyperglycemia, Metabolic syndrome, business, Biomarkers, Food Science, estudios transversales
Abstract

Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55&ndash, 75 years old, with overweight/obesity and MetS) in the PREvenci&oacute, n con DIeta MEDiterr&aacute, nea (PREDIMED)-Plus randomized trial. Methods: Assessment of fat intake (total fat, monounsatured fatty acids: MUFA, polyunsaturated fatty acids: PUFA, saturated fatty acids: SFA, trans-fatty acids: trans-FA, linoleic acid, &alpha, linolenic acid, and &omega, 3 FA) using a validated food frequency questionnaire, and diet quality using 17-item Mediterranean dietary questionnaire and fat quality index (FQI). Results: Participants in the highest quintile of total dietary fat intake showed lower intake of energy, carbohydrates, protein and fiber, but higher intake of PUFA, MUFA, SFA, TFA, LA, ALA and &omega, 3 FA. Differences in MetS components were found according to fat intake. Odds (5th vs. 1st quintile): hyperglycemia: 1.3&ndash, 1.6 times higher for total fat, MUFA, SFA and &omega, 3 FA intake, low high-density lipoprotein cholesterol (HDL-c): 1.2 higher for LA, hypertriglyceridemia: 0.7 lower for SFA and &omega, 3 FA intake. Conclusions: Dietary fats played different role on MetS components of high CVD risk patients. Dietary fat intake was associated with higher risk of hyperglycemia.

Published
2019
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14. Milk and Dairy Products Intake Is Related to Cognitive Impairment at Baseline in Predimed Plus Trial

Author

Lucia Prieto, Maria Dolors Zomeño, Aurora Bueno-Cavanillas, Isabel Cornejo-Pareja, Miquel Fiol, Jordi Salas-Salvadó, M. Rosa Bernal-Lopez, Xavier Pintó, Leire Goicolea-Güemez, Itziar Salaverria-Lete, Judith Pérez-Cabrera, Josep Vidal, Jessica Pérez-López, José Carlos Fernández-García, Ramon Estruch, Fernando Fernández-Aranda, Jesús Vioque, Olga Castañer, Indira Paz-Graniel, Patricia Guillem, Francisco J. Tinahones, Ángel M. Alonso-Gómez, Lidia Daimiel, Lucía Camacho-Barcia, Miguel Ángel Martínez-González, M Gimenez-Gracia, Luis Serra-Majem, Alejandro Oncina-Canovas, Helmut Schröder, Manuel Moñino, José Lapetra, Pilar Matía-Martín, PREDIMED-Plus Investigators, Laura Compañ-Gabucio, Dolores Corella, María Soria, Estefanía Toledo, Emilio Ros, Jose Lopez-Miranda, Miguel Delgado-Rodríguez, Carolina Ortega-Azorín, Leticia Miró-Moriano, Mònica Bulló, Vicente Martín Sánchez, Cristina Razquin, Araceli Muñoz-Garach, Josep A. Tur, Emilio Sacanella, Julia Wärnberg, Nuria Goñi, Dora Romaguera, and J. Alfredo Martínez

Subjects
Male, 0301 basic medicine, Consumption, Cultured Milk Products, Cognitive decline, Positive correlation, 03 medical and health sciences, Cognition, Animals, Humans, Medicine, Cognitive Dysfunction, Cognitive impairment, Aged, 2. Zero hunger, 030109 nutrition & dietetics, business.industry, Baseline data, Middle Aged, Predimed, Whole milk, Cross-Sectional Studies, Milk, 030104 developmental biology, Quartile, Female, Dairy Products, business, Food Science, Biotechnology, Demography
Abstract

Scope: To examine the association between milk and dairy products intake and the prevalence of cognitive decline among Spanish individuals at high cardiovascular risk. Methods and results: Cross-sectional analyses are performed on baseline data from 6744 adults (aged 55-75 years old). Intake of milk and dairy products is estimated using a food frequency questionnaire grouped into quartiles. The risk of developing cognitive impairment is based on the Mini-Mental State Examination (MMSE). A higher prevalence of cognitive decline was found in subjects who consumed more grams. Patients with worse MMSE score (10-24) consumed a mean of 395.14 ± 12.21 g, while patients with better MMSE score (27-30) consumed a mean of 341.23 ± 2.73 g (p < 0.05). Those subjects with the lower milk consumption (

Published
2021

15. Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study

Author

Laura Gallardo-Alfaro, Maria del Mar Bibiloni, Catalina M. Mascaró, Sofía Montemayor, Miguel Ruiz-Canela, Jordi Salas-Salvadó, Dolores Corella, Montserrat Fitó, Dora Romaguera, Jesús Vioque, Ángel M. Alonso-Gómez, Julia Wärnberg, J. Alfredo Martínez, Lluís Serra-Majem, Ramon Estruch, José Carlos Fernández-García, José Lapetra, Xavier Pintó, Antonio García Ríos, Aurora Bueno-Cavanillas, José J. Gaforio, Pilar Matía-Martín, Lidia Daimiel, Rafael M. Micó-Pérez, Josep Vidal, Clotilde Vázquez, Emilio Ros, Cesar Ignacio Fernandez-Lázaro, Nerea Becerra-Tomás, Ignacio Manuel Gimenez-Alba, María Dolors Zomeño, Jadwiga Konieczna, Laura Compañ-Gabucio, Lucas Tojal-Sierra, Jéssica Pérez-López, M. Ángeles Zulet, Tamara Casañas-Quintana, Sara Castro-Barquero, Ana María Gómez-Pérez, José Manuel Santos-Lozano, Ana Galera, F. Javier Basterra-Gortari, Josep Basora, Carmen Saiz, Karla Alejandra Pérez-Vega, Aina M. Galmés-Panadés, Cristina Tercero-Maciá, Carolina Sorto-Sánchez, Carmen Sayón-Orea, Jesús García-Gavilán, Júlia Muñoz-Martínez, and Josep A. Tur

Subjects
metabolic syndrome severity, physical activity, Mediterranean diet, depression risk, sedentary behaviour, Nutrition. Foods and food supply, TX341-641
Abstract

Healthy lifestyle factors, such as physical activity (PA) and Mediterranean diet (MD), decrease the likelihood of developing metabolic syndrome (MetS). The aim of this study was to report main lifestyle components and related factors according to the MetS severity. Cross-sectional analysis was done of baseline lifestyle factors from 5739 participants with overweight/obesity and MetS features (aged 55–75 years) included in the PREDIMED-PLUS primary cardiovascular prevention randomized trial. Participants were categorized in tertiles according to a validated MetS severity score (MetSSS). Anthropometrics, visceral adiposity index, dietary nutrient intake, biochemical marker levels, as well as a Dietary Inflammatory Index and depression symptoms (Beck Depression Inventory-II) were measured. Diet quality was assessed using a 17-item energy-restricted MD questionnaire. Duration and intensity of PA was self-reported using the Minnesota-REGICOR Short Physical Activity Questionnaire. Sedentary behaviours were measured using the Spanish version of the Nurses’ Health Study questionnaire. The 30 s chair stand test was also assessed. Participants with highest MetSSS showed higher values of cardiovascular risk factors (except for total cholesterol and LDL cholesterol), depression risk, sedentary and TV viewing time, and lower moderate and vigorous leisure-time physical activity (LTPA). Highest MetSSS participants tended to a pro-inflammatory dietary pattern and tended to lower MD adherence. In addition, they showed lower carbohydrate and nut intake and higher intake of protein, saturated and trans fatty acids, cholesterol, iodine, sodium, red and processed meat products, other oils different from olive oil and spirit alcoholic drinks. The highest MetS severity score was associated with lower moderate and vigorous LTPA and higher sedentary time and depression risk, as they tended to a pro-inflammatory dietary pattern and lower MD adherence.

Published
2020
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