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4 results on '"Maria Clara Borges de Andrade"'

1. Cancer patients diagnosed with COVID-19 infection: a multicenter retrospective cohort of nine Brazilian cancer centers

Author

Mariana Ribeiro Monteiro, Kaique Ferreira Costa de Almeida, Ana Beatriz Kinupe Abrahão, Camila Brambilla de Souza, Rafael Luis Moura Lima do Carmo, Maria Clara Borges de Andrade, Tuane Borges do Livramento Freitas, Cecilia Lameirinhas Longo, Maria Carolina Lopes Perdigão, Cynthia Lemos Ferreira, Tercia Tarciane Soares de Sousa, Angelo Maiolino, Sueli Monterroso da Cruz, Gustavo Henrique Munhoz Piotto, Fernando Meton de Alencar Camara Vieira, and Luiz Henrique Araujo

Subjects
coronavirus infections, sars virus, cancer symptoms, risk factors, clinical evolution, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Medicine
Abstract

Objectives: The COVID-19 infection was declared pandemic in March 2020. Since then, multiple studies have attempted to correlate clinical factors with the risk of complications from COVID-19. However, cancer patients are underrepresented in clinical trials and the results vary between different cohorts. Our goal is to describe a cohort of cancer patients and COVID-19. Methods: We conducted a multicenter retrospective study, based on a systematic review of medical records, including nine cancer centers, located in five different Brazilian cities. Patients were diagnosed with COVID-19 through RT-PCR between March 15th, 2020, and August 13th, 2020. Poisson regression models were then used to test for an association between clinical characteristics and severity of COVID-19 infections. Results: 102 patients had data collected for analysis, 85 (83.3%) of whom were hospitalized due to complications from COVID-19 infection. The median age was 65.8 years, most were female patients (61.8%) and white (73,5%). 78.4% had a performance status of 0-1, and the most common cancer subtypes were gastrointestinal (30.4%), breast (22.6%), and hematological (13.7%). Almost 40% of the population had stage IV disease. The mortality rate for all hospitalized patients was 36.5%, while that for those admitted to ICU was 68.4%. Key univariable risk factors for mortality included age (RR 1.03), ECOG = 2 (RR 1.83), hypertension (RR 1.72), lung metastasis (RR 1.67), and lymphocytes = 1000 admission (RR 2.40). At the multivariable analysis, the risk factors were also age (RR 1.02), primary lung cancer (RR 2.61), lung metastasis (RR 2.86), and coronary disease (RR 3.76). Conclusions: Despite the high mortality of patients hospitalized with COVID-19, cancer is a heterogeneous disease and some risk factors should be considered as the main responsible for the worst prognosis. Cancer patients should be carefully monitored in pandemic periods of infectious diseases and their management must be individualized.

Published
2021
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2. Patient-centered outcomes in non-small-cell lung cancer: a real-world perspective

Author

Pedro Nazareth Aguiar, Perla de Mello Andrade, Mauro Zukin, Clarissa Baldotto, Natalia Carvalho, Debora Victorino de Azevedo, Maria Clara Borges de Andrade, Raphaela Lima, Nelson Teich, Mayara Batista, Luiz H. Araujo, Cecilia Lameirinhas Longo, and Mariana Ribeiro Monteiro

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Adolescent, Kaplan-Meier Estimate, Emotional functioning, Young Adult, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Cost of Illness, Quality of life, Risk Factors, Carcinoma, Non-Small-Cell Lung, Surveys and Questionnaires, Internal medicine, medicine, Humans, Patient Reported Outcome Measures, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Lung cancer, Fatigue, Survival analysis, Aged, business.industry, Patient-centered outcomes, Cancer, Cancer Pain, General Medicine, Middle Aged, medicine.disease, Oncology, 030220 oncology & carcinogenesis, Quality of Life, Female, Non small cell, business, Brazil
Abstract

Aims: To assess non-small-cell lung cancer (NSCLC) patient-centered outcomes in the real world. Methods: This is a prospective study of NSCLC patients treated at a private cancer care institution in Brazil between 2014 and 2019. Results: The report comprises 337 patients. Advanced stage was associated with higher symptom burden – fatigue (p = 0.03), pain (p

Published
2021

3. Cancer patients diagnosed with COVID-19 infection: a multicenter retrospective cohort of nine Brazilian cancer centers

Author

Tuane Borges do Livramento Freitas, Mariana Ribeiro Monteiro, Angelo Maiolino, Kaique Ferreira Costa de Almeida, Cynthia Lemos Ferreira, Maria Clara Borges de Andrade, Camila Brambilla Souza, Ana Beatriz Kinupe Abrahao, Luiz H. Araujo, F. M. Vieira, Sueli Monterroso da Cruz, Tercia Tarciane Soares de Sousa, Gustavo Henrique Munhoz Piotto, Maria Carolina Lopes Perdigao, Rafael Luis Moura Lima do Carmo, and Cecilia Lameirinhas Longo

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Internal medicine, medicine, Cancer, Retrospective cohort study, medicine.disease, business
Published
2021

4. Cancer patients diagnosed with COVID-19 infection: A multicenter retrospective cohort of nine Brazilian cancer centers

Author

Gustavo Henrique Munhoz Piotto, Camila Brambilla Souza, Daniela Pezzutti, Cecilia Lameirinhas Longo, Mariana Ribeiro Monteiro, Maria Clara Borges de Andrade, Cynthia Lemos Ferreira, Sueli Monterroso da Cruz, Tercia Tarciane Soares de Sousa, Maria Carolina Lopes Perdigao, Luiz H. Araujo, Angelo Maiolino, Kaique Ferreira Costa de Almeida, Ana Beatriz Kinupe Abrahao, Tiago Costa de Padua, F. M. Vieira, Rafael Luis Moura Lima do Carmo, and Tuane Borges do Livramento Freitas

Subjects
Cancer Research, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Cancer, Retrospective cohort study, medicine.disease, Oncology, Internal medicine, Pandemic, Medicine, business
Abstract

e13600 Background: The COVID-19 infection was declared pandemic in March 2020. Since then, multiple studies have attempted to correlate clinical factors with risk of complications from COVID-19, including cancer. However, cancer patients are underrepresented in clinical trials and the results vary between different cohorts. Methods: We conducted a multicentre retrospective study, based on systematic review of medical records, including nine cancer centers, located in five different Brazilian cities. Patients were diagnosed with COVID-19 through RT-PCR between March 15, 2020 and August 13 , 2020. Poisson regression models were then used to test for an association between clinical characteristics and severity of COVID-19 infections. Results: 102 patients had data collected for analysis, 85 (83.3%) of whom were hospitalized due to complications from COVID-19 infection. The median age was 65.8 years, most were female patients (61.8%) and white (73,5%). 78.4% had a performance status of 0-1, and the most common cancer subtypes were gastrointestinal (30.4%), breast (22.6%) and hematological (13.7%). Almost 40% of population had stage IV disease. Mortality rate for all hospitalized patients was 36.5%, while for those admitted to the ICU it was 68.4%. Key univariable risk factors for mortality included age (RR 1.03), ECOG ≥ 2 (RR 1.83), hypertension (RR 1.72), lung metastasis (RR 1.67), and lymphocytes ≤ 1000 admission (RR 2.40). At the multivariable analysis, the risk factors were also age (RR 1.02), primary lung cancer (RR 2.61), lung metastasis (RR 2.86), and coronary disease (RR 3.76). Conclusions: Despite the high mortality of patients hospitalized with COVID-19, our data are compatible with other cohorts. Cancer patients must be carefully monitored in pandemic periods of infectious diseases.

Published
2021

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