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1,022 results on '"Maria, Ruggero"'

1. The 1+Million Genomes Minimal Dataset for Cancer

Author

Riba, Michela, Sala, Cinzia, Culhane, Aedin C., Flobak, Åsmund, Patocs, Attila, Boye, Kjetil, Plevova, Karla, Pospíšilová, Šárka, Gandolfi, Giorgia, Morelli, Marco J., Bucci, Gabriele, Edsjö, Anders, Lassen, Ulrik, Al-Shahrour, Fátima, Lopez-Bigas, Nuria, Hovland, Randi, Cuppen, Edwin, Valencia, Alfonso, Poirel, Helene A., Rosenquist, Richard, Scollen, Serena, Arenas Marquez, Juan, Belien, Jeroen, De Nicolo, Arcangela, De Maria, Ruggero, Torrents, David, and Tonon, Giovanni

Published
2024
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2. Comprehensive genomic profiling on metastatic Melanoma: results from a network screening from 7 Italian Cancer Centres

Author

Pallocca, Matteo, Molineris, Ivan, Berrino, Enrico, Marcozzi, Benedetta, Betti, Martina, Levati, Lauretta, D’Atri, Stefania, Menin, Chiara, Madonna, Gabriele, Ghiorzo, Paola, Bulgarelli, Jenny, Ferraresi, Virgina, Venesio, Tiziana, Rodolfo, Monica, Rivoltini, Licia, Lanfrancone, Luisa, Ascierto, Paolo Antonio, Mazzarella, Luca, Pelicci, Pier Giuseppe, De Maria, Ruggero, Ciliberto, Gennaro, Medico, Enzo, and Russo, Giandomenico

Published
2024
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3. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Aqeilan, Rami I, Arama, Eli, Baehrecke, Eric H, Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A, Bartek, Jiri, Bazan, Nicolas G, Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu JM, Bianchi, Marco E, Blagosklonny, Mikhail V, Blander, J Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D, Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A, Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M, Dawson, Valina L, De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J, Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J Marie, Haupt, Ygal, He, Sudan, Heery, David M, Hengartner, Michael O, Hetz, Claudio, Hildeman, David A, Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J, and Kanneganti, Thirumala-Devi

Subjects
Biochemistry and Cell Biology, Biological Sciences, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Good Health and Well Being, Animals, Humans, Apoptosis, Cell Death, Caspases, Carcinogenesis, Mammals, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Published
2023

5. Correction to: L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fbrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients

Author

Lo Cicero, Stefania, Castelli, Germana, Blaconà, Giovanna, Bruno, Sabina Maria, Sette, Giovanni, Pigliucci, Riccardo, Villella, Valeria Rachela, Esposito, Speranza, Zollo, Immacolata, Spadaro, Francesca, De Maria, Ruggero, Biffoni, Mauro, Cimino, Giuseppe, Amato, Felice, Lucarelli, Marco, and Eramo, Adriana

Published
2023
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6. L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fibrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients

Author

Lo Cicero, Stefania, Castelli, Germana, Blaconà, Giovanna, Bruno, Sabina Maria, Sette, Giovanni, Pigliucci, Riccardo, Villella, Valeria Rachela, Esposito, Speranza, Zollo, Immacolata, Spadaro, Francesca, Maria, Ruggero De, Biffoni, Mauro, Cimino, Giuseppe, Amato, Felice, Lucarelli, Marco, and Eramo, Adriana

Published
2023
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7. Tackling the implementation gap for the uptake of NGS and advanced molecular diagnostics into healthcare systems

Author

Horgan, Denis, Van den Bulcke, Marc, Malapelle, Umberto, Troncone, Giancarlo, Normanno, Nicola, Capoluongo, Ettore D., Prelaj, Arsela, Rizzari, Carmelo, Trapani, Dario, Singh, Jaya, Kozaric, Marta, Longshore, John, Ottaviano, Manuel, Boccia, Stefania, Pravettoni, Gabriella, Cattaneo, Ivana, Malats, Núria, Buettner, Reinhard, Lekadir, Karim, de Lorenzo, Francesco, Hofman, Paul, and De Maria, Ruggero

Published
2024
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10. Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Author

Musella, Martina, Guarracino, Andrea, Manduca, Nicoletta, Galassi, Claudia, Ruggiero, Eliana, Potenza, Alessia, Maccafeo, Ester, Manic, Gwenola, Mattiello, Luca, Soliman Abdel Rehim, Sara, Signore, Michele, Pietrosanto, Marco, Helmer-Citterich, Manuela, Pallocca, Matteo, Fanciulli, Maurizio, Bruno, Tiziana, De Nicola, Francesca, Corleone, Giacomo, Di Benedetto, Anna, Ercolani, Cristiana, Pescarmona, Edoardo, Pizzuti, Laura, Guidi, Francesco, Sperati, Francesca, Vitale, Sara, Macchia, Daniele, Spada, Massimo, Schiavoni, Giovanna, Mattei, Fabrizio, De Ninno, Adele, Businaro, Luca, Lucarini, Valeria, Bracci, Laura, Aricò, Eleonora, Ziccheddu, Giovanna, Facchiano, Francesco, Rossi, Stefania, Sanchez, Massimo, Boe, Alessandra, Biffoni, Mauro, De Maria, Ruggero, Vitale, Ilio, and Sistigu, Antonella

Published
2022
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11. Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51

Author

Turdo, Alice, Gaggianesi, Miriam, Di Franco, Simone, Veschi, Veronica, D’Accardo, Caterina, Porcelli, Gaetana, Lo Iacono, Melania, Pillitteri, Irene, Verona, Francesco, Militello, Gabriella, Zippo, Alessio, Poli, Vittoria, Fagnocchi, Luca, Beyes, Sven, Stella, Stefania, Lattanzio, Rossano, Faldetta, Naida, Lentini, Vincenzo L., Porcasi, Rossana, Pistone, Giuseppe, Bongiorno, Maria Rita, Stassi, Giorgio, De Maria, Ruggero, and Todaro, Matilde

Published
2022
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12. Bridging therapeutic opportunities: a survey by the Italian molecular tumor board workgroup of Alliance Against Cancer

Author

Ciliberto, Gennaro, Canfora, Marco, Terrenato, Irene, Agnoletto, Chiara, Agustoni, Francesco, Amoroso, Loredana, Baldassarre, Gustavo, Curigliano, Giuseppe, Delmonte, Angelo, De Luca, Antonella, Fiorentino, Michelangelo, Gregorc, Vanesa, Ibrahim, Toni, Lazzari, Chiara, Mastronuzzi, Angela, Pronzato, Paolo, Santoro, Armando, Scambia, Giovanni, Tommasi, Stefania, Vingiani, Andrea, Giacomini, Patrizio, and De Maria, Ruggero

Published
2022
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13. An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile

Author

De Angelis, Maria Laura, Francescangeli, Federica, Nicolazzo, Chiara, Signore, Michele, Giuliani, Alessandro, Colace, Lidia, Boe, Alessandra, Magri, Valentina, Baiocchi, Marta, Ciardi, Antonio, Scarola, Francesco, Spada, Massimo, La Torre, Filippo, Gazzaniga, Paola, Biffoni, Mauro, De Maria, Ruggero, and Zeuner, Ann

Published
2022
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14. A real-time integrated framework to support clinical decision making for covid-19 patients

Author

Murri, Rita, Masciocchi, Carlotta, Lenkowicz, Jacopo, Fantoni, Massimo, Damiani, Andrea, Marchetti, Antonio, Sergi, Paolo Domenico Angelo, Arcuri, Giovanni, Cesario, Alfredo, Patarnello, Stefano, Antonelli, Massimo, Bellantone, Rocco, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Landolfi, Raffaele, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, and Valentini, Vincenzo

Published
2022
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15. Advancements in 3D In Vitro Models for Colorectal Cancer.

Author

Vitale, Sara, Calapà, Federica, Colonna, Francesca, Luongo, Francesca, Biffoni, Mauro, De Maria, Ruggero, and Fiori, Micol E.

Subjects
COLORECTAL cancer, DRUG discovery, CANCER patients, DRUG efficacy, MEDICATION safety, HUMAN body, ANIMAL models in research
Abstract

The process of drug discovery and pre‐clinical testing is currently inefficient, expensive, and time‐consuming. Most importantly, the success rate is unsatisfactory, as only a small percentage of tested drugs are made available to oncological patients. This is largely due to the lack of reliable models that accurately predict drug efficacy and safety. Even animal models often fail to replicate human‐specific pathologies and human body's complexity. These factors, along with ethical concerns regarding animal use, urge the development of suitable human‐relevant, translational in vitro models. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Author

Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Annicchiarico-Petruzzelli, Margherita, Antonov, Alexey V, Arama, Eli, Baehrecke, Eric H, Barlev, Nickolai A, Bazan, Nicolas G, Bernassola, Francesca, Bertrand, Mathieu JM, Bianchi, Katiuscia, Blagosklonny, Mikhail V, Blomgren, Klas, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chandel, Navdeep S, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Cohen, Gerald M, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D’Angiolella, Vincenzo, Dawson, Ted M, Dawson, Valina L, De Laurenzi, Vincenzo, De Maria, Ruggero, Debatin, Klaus-Michael, DeBerardinis, Ralph J, Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M, Dixon, Scott J, Duckett, Colin S, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Fimia, Gian Maria, Fulda, Simone, García-Sáez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Golstein, Pierre, Gottlieb, Eyal, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J Marie, Harris, Isaac S, Hengartner, Michael O, Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Joseph, Bertrand, Jost, Philipp J, Juin, Philippe P, Kaiser, William J, Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N, Klionsky, Daniel J, Knight, Richard A, Kumar, Sharad, Lee, Sam W, Lemasters, John J, Levine, Beth, Linkermann, Andreas, Lipton, Stuart A, Lockshin, Richard A, López-Otín, Carlos, Lowe, Scott W, Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, and Manic, Gwenola

Subjects
Biochemistry and Cell Biology, Biological Sciences, Animals, Cell Death, Humans, Lysosomes, Mitochondrial Membrane Transport Proteins, Mitochondrial Permeability Transition Pore, Necrosis, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

Published
2018

17. KEAP1 and TP53 Frame Genomic, Evolutionary, and Immunologic Subtypes of Lung Adenocarcinoma With Different Sensitivity to Immunotherapy

Author

Scalera, Stefano, Mazzotta, Marco, Corleone, Giacomo, Sperati, Francesca, Terrenato, Irene, Krasniqi, Eriseld, Pizzuti, Laura, Barba, Maddalena, Vici, Patrizia, Gallo, Enzo, Buglioni, Simonetta, Visca, Paolo, Pescarmona, Edoardo, Marinelli, Daniele, De Nicola, Francesca, Ciuffreda, Ludovica, Goeman, Frauke, Fanciulli, Maurizio, Giusti, Raffaele, Vecchione, Andrea, De Maria, Ruggero, Cappuzzo, Federico, Marchetti, Paolo, Ciliberto, Gennaro, and Maugeri-Saccà, Marcello

Published
2021
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18. Demographic Analysis of Cancer Research Priorities and Treatment Correlations

Author

Horgan, Denis, primary, Bulcke, Marc Van den, additional, Malapelle, Umberto, additional, Normanno, Nicola, additional, Capoluongo, Ettore D., additional, Prelaj, Arsela, additional, Rizzari, Carmelo, additional, Stathopoulou, Aliki, additional, Singh, Jaya, additional, Kozaric, Marta, additional, Dube, France, additional, Ottaviano, Manuel, additional, Boccia, Stefania, additional, Pravettoni, Gabriella, additional, Cattaneo, Ivana, additional, Malats, Núria, additional, Buettner, Reinhard, additional, Lekadir, Karim, additional, de Lorenzo, Francesco, additional, Alix-Panabieres, Catherine, additional, Badreh, Sara, additional, Solary, Eric, additional, De Maria, Ruggero, additional, and Hofman, Paul, additional

Published
2024
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19. Uracil‐ and Pyridine‐Containing HDAC Inhibitors Displayed Cytotoxicity in Colorectal and Glioblastoma Cancer Stem Cells

Author

Fiorentino, Francesco, primary, Fabbrizi, Emanuele, additional, Raucci, Alessia, additional, Noce, Beatrice, additional, Fioravanti, Rossella, additional, Valente, Sergio, additional, Paolini, Chantal, additional, De Maria, Ruggero, additional, Steinkühler, Christian, additional, Gallinari, Paola, additional, Rotili, Dante, additional, and Mai, Antonello, additional

Published
2024
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20. CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin

Author

Di Franco, Simone, Parrino, Barbara, Gaggianesi, Miriam, Pantina, Vincenzo Davide, Bianca, Paola, Nicotra, Annalisa, Mangiapane, Laura Rosa, Lo Iacono, Melania, Ganduscio, Gloria, Veschi, Veronica, Brancato, Ornella Roberta, Glaviano, Antonino, Turdo, Alice, Pillitteri, Irene, Colarossi, Lorenzo, Cascioferro, Stella, Carbone, Daniela, Pecoraro, Camilla, Fiori, Micol Eleonora, De Maria, Ruggero, Todaro, Matilde, Screpanti, Isabella, Cirrincione, Girolamo, Diana, Patrizia, and Stassi, Giorgio

Published
2021
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21. Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

Author

Manic, Gwenola, Musella, Martina, Corradi, Francesca, Sistigu, Antonella, Vitale, Sara, Soliman Abdel Rehim, Sara, Mattiello, Luca, Malacaria, Eva, Galassi, Claudia, Signore, Michele, Pallocca, Matteo, Scalera, Stefano, Goeman, Frauke, De Nicola, Francesca, Guarracino, Andrea, Pennisi, Rosa, Antonangeli, Fabrizio, Sperati, Francesca, Baiocchi, Marta, Biffoni, Mauro, Fanciulli, Maurizio, Maugeri-Saccà, Marcello, Franchitto, Annapaola, Pichierri, Pietro, De Maria, Ruggero, and Vitale, Ilio

Published
2021
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22. Aligning Cancer Research Priorities in Europe with Recommendations for Conquering Cancer: A Comprehensive Analysis

Author

Horgan, Denis, primary, Bulcke, Marc Van den, additional, Malapelle, Umberto, additional, Normanno, Nicola, additional, Capoluongo, Ettore D., additional, Prelaj, Arsela, additional, Rizzari, Carmelo, additional, Stathopoulou, Aliki, additional, Singh, Jaya, additional, Kozaric, Marta, additional, Dube, France, additional, Ottaviano, Manuel, additional, Boccia, Stefania, additional, Pravettoni, Gabriella, additional, Cattaneo, Ivana, additional, Malats, Núria, additional, Buettner, Reinhard, additional, Lekadir, Karim, additional, de Lorenzo, Francesco, additional, Blanc, Patricia, additional, Alix-Panabieres, Catherine, additional, Badreh, Sara, additional, Hofman, Paul, additional, Solary, Eric, additional, and De Maria, Ruggero, additional

Published
2024
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23. The prognostic relevance of HER2-positivity gain in metastatic breast cancer in the ChangeHER trial

Author

Pizzuti, Laura, Barba, Maddalena, Mazzotta, Marco, Krasniqi, Eriseld, Maugeri-Saccà, Marcello, Gamucci, Teresa, Berardi, Rossana, Livi, Lorenzo, Ficorella, Corrado, Natoli, Clara, Cortesi, Enrico, Generali, Daniele, La Verde, Nicla, Cassano, Alessandra, Bria, Emilio, Moscetti, Luca, Michelotti, Andrea, Adamo, Vincenzo, Zamagni, Claudio, Tonini, Giuseppe, Sergi, Domenico, Marinelli, Daniele, Paoletti, Giancarlo, Tomao, Silverio, Botticelli, Andrea, Marchetti, Paolo, Tinari, Nicola, Grassadonia, Antonino, Valerio, Maria Rosaria, Mirabelli, Rosanna, Fabbri, Maria Agnese, D’Ostilio, Nicola, Veltri, Enzo, Corsi, Domenico, Garrone, Ornella, Paris, Ida, Sarobba, Giuseppina, Meattini, Icro, Pistelli, Mirco, Giotta, Francesco, Lorusso, Vito, Garufi, Carlo, Russo, Antonio, Cazzaniga, Marina, Del Medico, Pietro, Roselli, Mario, Vaccaro, Angela, Perracchio, Letizia, di Benedetto, Anna, Daralioti, Theodora, Sperduti, Isabella, De Maria, Ruggero, Di Leo, Angelo, Sanguineti, Giuseppe, Ciliberto, Gennaro, and Vici, Patrizia

Published
2021
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24. Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery

Author

Di Franco, Simone, Bianca, Paola, Sardina, Davide Stefano, Turdo, Alice, Gaggianesi, Miriam, Veschi, Veronica, Nicotra, Annalisa, Mangiapane, Laura Rosa, Lo Iacono, Melania, Pillitteri, Irene, van Hooff, Sander, Martorana, Federica, Motta, Gianmarco, Gulotta, Eliana, Lentini, Vincenzo Luca, Martorana, Emanuele, Fiori, Micol Eleonora, Vieni, Salvatore, Bongiorno, Maria Rita, Giannone, Giorgio, Giuffrida, Dario, Memeo, Lorenzo, Colarossi, Lorenzo, Mare, Marzia, Vigneri, Paolo, Todaro, Matilde, De Maria, Ruggero, Medema, Jan Paul, and Stassi, Giorgio

Published
2021
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26. Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma

Author

Goeman, Frauke, De Nicola, Francesca, Scalera, Stefano, Sperati, Francesca, Gallo, Enzo, Ciuffreda, Ludovica, Pallocca, Matteo, Pizzuti, Laura, Krasniqi, Eriseld, Barchiesi, Giacomo, Vici, Patrizia, Barba, Maddalena, Buglioni, Simonetta, Casini, Beatrice, Visca, Paolo, Pescarmona, Edoardo, Mazzotta, Marco, De Maria, Ruggero, Fanciulli, Maurizio, Ciliberto, Gennaro, and Maugeri-Saccà, Marcello

Published
2019
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27. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Associazione Italiana per la Ricerca sul Cancro, Italian Institute for Genomic Medicine, Compagnia di San Paolo, Vitale, Ilio [0000-0002-5918-1841], Pietrocola, Federico [0000-0002-2930-234X], Guilbaud, Emma [0000-0001-5261-1944], Aaronson, Stuart A. [0000-0002-4643-0474], Dieter, Adam [0000-0002-5668-5032], Agostini, Massimiliano [0000-0003-3124-2072], Agostinis, Patrizia [0000-0003-1314-2115], Alnemri, Emad S. [0000-0002-7295-3383], Altucci, Lucia [0000-0002-7312-5387], Amelio, Ivano [0000-0002-9126-5391], Andrews, David W. [0000-0002-9266-7157], Aqeilan, Rami I. [0000-0002-6034-023X], Arama, Eli [0000-0001-5953-0629], Balachandran, Siddharth [0000-0003-2084-1803], Bano, Daniele [0000-0002-9617-5504], Bartek, Jiri [0000-0003-2013-7525], Bazan, Nicolas G. [0000-0002-9243-5444], Bernassola, Francesca [0000-0002-8883-8654], Bertrand, Mathieu J. M. [0000-0001-9000-0626], Bianchi, Marco Emilio [0000-0002-5329-6445], Blander, J. Magarian [0000-0001-9207-1700], Blandino, Giovanni [0000-0002-6970-2241], Blomgren, Klas [0000-0002-0476-7271], Bortner, Carl D. [0000-0002-5444-6628], Bove, Pierluigi [0000-0002-4788-2982], Boya, Patricia [0000-0003-3045-951X], Broz, Petr [0000-0002-2334-7790], Damgaard, Rune Busk [0000-0002-1709-6534], Calin, George A. [0000-0002-7427-0578], Campanella, Michelangelo [0000-0002-6948-4184], Candi, Eleonora [0000-0001-8332-4825], Carbone, Michele [0000-0001-8928-8474], Carmona-Gutierrez, Didac [0000-0001-7548-7771], Cecconi, Francesco [0000-0002-5614-4359], Chen, Guo‑Qiang [0000-0002-7226-1782], Cheng, Emily H. [0000-0002-3595-2648], Chipuk, Jerry E. [0000-0002-1337-842X], Cidlowski, John A. [0000-0003-1420-0516], Ciechanover, Aaron [0000-0001-9184-8944], Ciliberto, Gennaro [0000-0003-2851-8605], Conrad, Marcus [0000-0003-1140-5612], Czabotar, Peter E. [0000-0002-2594-496X], D’Angiolella, Vincenzo [0000-0001-8365-9094], Daugaard, Mads [0000-0001-8383-055X], Dawson, Valina L. [0000-0002-2915-3970], De Maria, Ruggero [0000-0003-2255-0583], Debatin, Klaus-Michael [0000-0002-8397-1886], Deberardinis, Ralph J. [0000-0002-2705-7432], Degterev, Alexei [0000-0002-8240-7132], Del Sal, Giannino [0000-0003-2185-6003], Deshmukh, Mohanish [0000-0002-2597-5862], Di Virgilio, Francesco [0000-0003-3566-1362], Diederich, Marc [0000-0003-0115-4725], Dixon, Scott J. [0000-0001-6230-8199], El-Deiry, Wafik S. [0000-0002-9577-8266], Elrod, John W. [0000-0003-3925-2224], Engeland, Kurt [0000-0003-3525-0440], Fimia, Gian María [0000-0003-4438-3325], Ganini, Carlo [0000-0002-5839-3965], García-Sáez, Ana J. [0000-0002-3894-5945], Garg, Abhishek D. [0000-0002-9976-9922], Garrido, Carmen [0000-0003-1368-1493], Gavathiotis, Evripidis [0000-0001-6319-8331], Ghosh, Sourav [0000-0001-5990-8708], Green, Douglas R. [0000-0002-7332-1417], Gronemeyer, Hinrich [0000-0001-9454-2449}, Häcker, Georg [0000-0003-1058-5746], Hajnóczky, György [0000-0003-3813-2570], Hardwick, J. 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[0000-0002-3532-3868], Strappazzon, Flavie [0000-0003-0285-7449], Sun, Liming [0000-0002-0136-5605], Sun, Erwei [0000-0001-5664-513X], Szabadkai, G [0000-0002-3006-3577], Tait, Stephen W. G. [0000-0001-7697-132X], Tang, Daolin [0000-0002-1903-6180], Tavernarakis, Nektarios [0000-0002-5253-1466], Turk, Boris [0000-0002-9007-5764], Urbano, Nicoletta [0000-0003-1822-155X], Vandenabeele, Peter [0000-0002-6669-8822], Vanden Berghe, Tom [0000-0002-1633-0974], Vander Heiden, Matthew G. [0000-0002-6702-4192], Vanderluit, Jacqueline L. [0000-0002-4960-920X], Verkhratsky, A. [0000-0003-2592-9898], Villunger, Andreas [0000-0001-8259-4153], Von Karstedt, Silvia [0000-0002-7816-5919], Voss, Anne K. [0000-0002-3853-9381], Vucic, Domagoj [0000-0003-3614-8093], Vuri, Daniela [0000-0001-8693-3845], Wagner, Erwin F. [0000-0001-7872-0196], Walczak, Henning [0000-0002-6312-4591], Wallach, David [0000-0003-2724-9757], Wang, Ruoning [0000-0001-9798-8032], Weber, Achim [0000-0003-0073-3637], Yamazaki, Takahiro [0000-0002-7420-4394], Zakeri, Zahra [0000-0003-4386-8072], Zawacka-Pankau, Joanna E. [0000-0002-7415-2942], Zhivotovsky, Boris [0000-0002-2238-3482], Piacentini, Mauro [0000-0003-2919-1296], Kroemer, Guido [0000-0002-9334-4405], Galluzzi, Lorenzo [0000-0003-2257-8500 ], Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Dieter, Adam, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco Emilio, Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Bomer, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, T., Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K.-M., Chen, Guo‑Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, B., Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian María, Galassi, Claudia, Ganini, Carlo, García-Sáez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravinchandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strappazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, G, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, A., Villunger, Andreas, Von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Zahra, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibin, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, and Galluzzi, Lorenzo

Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Published
2023

28. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant

Author

Veschi, Veronica, Mangiapane, Laura R., Nicotra, Annalisa, Di Franco, Simone, Scavo, Emanuela, Apuzzo, Tiziana, Sardina, Davide S., Fiori, Micol, Benfante, Antonina, Colorito, Maria L., Cocorullo, Gianfranco, Giuliante, Felice, Cipolla, Calogero, Pistone, Giuseppe, Bongiorno, Maria Rita, Rizzo, Aroldo, Tate, Courtney M., Wu, Xiaohua, Rowlinson, Scott, Stancato, Louis F., Todaro, Matilde, De Maria, Ruggero, and Stassi, Giorgio

Published
2020
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29. Diagnostic and prognostic potential of the proteomic profiling of serum-derived extracellular vesicles in prostate cancer

Author

Signore, Michele, Alfonsi, Romina, Federici, Giulia, Nanni, Simona, Addario, Antonio, Bertuccini, Lucia, Aiello, Aurora, Di Pace, Anna Laura, Sperduti, Isabella, Muto, Giovanni, Giacobbe, Alessandro, Collura, Devis, Brunetto, Lidia, Simone, Giuseppe, Costantini, Manuela, Crinò, Lucio, Rossi, Stefania, Tabolacci, Claudio, Diociaiuti, Marco, Merlino, Tania, Gallucci, Michele, Sentinelli, Steno, Papalia, Rocco, De Maria, Ruggero, and Bonci, Désirée

Published
2021
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30. Transcriptional phenocopies of deleterious KEAP1 mutations dictate survival outcomes in lung cancer treated with immunotherapy.

Author

Scalera, Stefano, primary, Ricciuti, Biagio, additional, Marinelli, Daniele, additional, Mazzotta, Marco, additional, Cipriani, Laura, additional, Bon, Giulia, additional, Schiavoni, Giulia, additional, Terrenato, Irene, additional, Di Federico, Alessandro, additional, Alessi, Joao, additional, Fanciulli, Maurizio, additional, Ciuffreda, Ludovica, additional, De Nicola, Francesca, additional, Goeman, Frauke, additional, Caravagna, Giulio, additional, Santini, Daniele, additional, De Maria, Ruggero, additional, Cappuzzo, Federico, additional, Ciliberto, Gennaro, additional, Jamal-Hanjani, Mariam, additional, Awad, Mark, additional, McGranahan, Nicholas, additional, and Maugeri-Saccà, Marcello, additional

Published
2023
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31. Mobilising Collaboration among Stakeholders to Optimise the Growing Potential of Data for Tackling Cancer

Author

Horgan, Denis, primary, Van den Bulcke, Marc, additional, Malapelle, Umberto, additional, Normanno, Nicola, additional, Capoluongo, Ettore D., additional, Prelaj, Arsela, additional, Rizzari, Carmelo, additional, Stathopoulou, Aliki, additional, Singh, Jaya, additional, Kozaric, Marta, additional, Dube, France, additional, Ottaviano, Manuel, additional, Boccia, Stefania, additional, Pravettoni, Gabriella, additional, Cattaneo, Ivana, additional, Malats, Núria, additional, Buettner, Reinhard, additional, Lekadir, Karim, additional, de Lorenzo, Francesco, additional, Alix-Panabieres, Catherine, additional, Badreh, Sara, additional, Hofman, Paul, additional, De Maria, Ruggero, additional, and Solary, Eric, additional

Published
2023
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32. The Minimal Dataset for Cancer of the 1+Million Genomes Initiative

Author

Riba, Michela, primary, Sala, Cinzia, additional, Culhane, Aedin, additional, Flobak, Asmund, additional, Patocs, Attila, additional, Boye, Kjetil, additional, Plevova, Karla, additional, Pospisilova, Sarka, additional, Gandolfi, Giorgia, additional, Morelli, Marco, additional, Bucci, Gabriele, additional, Edsjo, Anders, additional, Lassen, Ulrik, additional, Al-Shahrour, Fatima, additional, Lopez-Bigas, Nuria, additional, Hovland, Randi, additional, Cuppen, Edwin, additional, Valencia, Alfonso, additional, Antoine-Poirel, Helene, additional, Rosenquist Brandell, Richard, additional, Scollen, Serena, additional, Arenas Marquez, Juan, additional, Belien, Jeroen, additional, De Nicolo, Arcangela, additional, De Maria, Ruggero, additional, Torrents, David, additional, and Tonon, Giovanni, additional

Published
2023
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33. OMICS AND PROGNSTIC MARKERS

Author

Larson, Peder, Yoshihara, Hikari, Vigneron, Daniel, Nelson, Sarah, Pieper, Russell, Phillips, Joanna, Ronen, Sabrina, Clark, Victoria, Omay, Zeynep, Serin, Akdes, Günel, Jennifer, Omay, Bulent, Grady, Conor, Youngblood, Mark, Bilgüvar, Kaya, Baehring, Joachim, Piepmeier, Joseph, Gutin, Philip, Vortmeyer, Alexander, Brennan, Cameron, Pamir, M, Kilic, Türker, Krischek, Boris, Simon, Matthias, Yasuno, Katsuhito, Günel, Murat, Cohen, Adam, Sato, Mariko, Aldape, Kenneth, Mason, Clint, Diefes, Kristen, Heathcock, Lindsey, Abegglen, Lisa, Shrieve, Dennis, Couldwell, William, Schiffman, Joshua, Colman, Howard, DAlessandris, Quintino, Cenci, Tonia, Martini, Maurizio, Ricci-Vitiani, Lucia, De Maria, Ruggero, Larocca, Luigi, Pallini, Roberto, de Groot, John, Theeler, Brett, Lang, Frederick, Rao, Ganesh, Gilbert, Mark, Sulman, Erik, Luthra, Raja, Eterovic, Karina, Chen, Ken, Routbort, Mark, Verhaak, Roeland, Mills, Gordon, Mendelsohn, John, Meric-Bernstam, Funda, Yung, Alfred, Fujii, Kentaro, Kurozumi, Kazuhiko, Ichikawa, Tomotsugu, Onishi, Manabu, Ishida, Joji, Shimazu, Yosuke, Kaur, Balveen, Chiocca, E, Date, Isao, Geisenberger, Christoph, Mock, Andreas, Warta, Rolf, Schwager, Christian, Hartmann, Christian, von Deimling, Andreas, Abdollahi, Amir, Herold-Mende, Christel, Gevaert, Olivier, Achrol, Achal, Gholamin, Sharareh, Mitra, Siddhartha, Westbroek, Erick, Loya, Joshua, Mitchell, Lex, Chang, Steven, Steinberg, Gary, Plevritis, Sylvia, Cheshier, Samuel, Xu, Jiajing, Napel, Sandy, and Zaharchuk, Greg

Abstract

Although histopathological diagnosis is essential in decision of therapeutic strategy for gliomas, sometimes the tumors diagnosed in one histological entity show thoroughly different clinical courses. This phenomenon is believed to be due primarily to the presence of the genetic subgroup. In fact, relationship between treatment response and certain genetic characteristics is indicated (e.g. better chemosensitivity in glioma with losses of 1p/19q (−1p/19q)). It is highly likely that genetic classification of glioma is useful to select the adjuvant treatment. Additionally, gain of 7q (+7q) and −1p/19q are early events in 2 distinct tumor lineages, astrocytic tumors and oligodendroglial tumors, respectively, and these tumors obtain additional genetic aberration (−9p, 10q) with tumor progression. On the other hand, concerning the tumors without +7q or −1p/19q, little is known about clinically important genetic aberration. Therefore the study on such tumors could provide useful information for the prognosis prediction and the determination of treatment strategy. METHODS: We selected 39 cases of gliomas without +7q or −1p/19q from 200 adult supratentorial glioma cases surgically treated and analyzed chromosomal DNA copy number aberrations (CNAs) by comparative genomic hybridization (CGH) from 2005 to 2012. We correlated clinical features of these tumors with histological characteristics, CNAs and IDH1 status. RESULTS: The clinical course of gliomas without +7q or −1p/19q was not correlated with additional genetic aberration of -9p or 10q, which have been known as genetic markers for poor prognosis, and absence of +7q or −1p/19q was maintained at the time of recurrence. The tumors without +7q or −1p/19q showed relatively favorable prognosis although mutation of IDH1 was infrequent in these tumors (35.8 %). CONCLUSION: The gliomas without +7q or −1p/19q have clinical features distinct from the +7q and −1p/19q gliomas. Prognostic markers for each subgroups could help establish therapeutic strategy against the tumor. DNA methylation is a mechanism altering the normal state of cells implicated in many cancers. Currently the methylation status of MGMT is one of the most widely utilized clinical genetic tests performed on glioblastoma multiforme (GBM). While several global gene expression signatures have been developed, it is unclear if genome-wide DNA methylation signatures can predict prognosis in cancer. We used a computational algorithm (MethylMix) to analyze genome-wide DNA methylation in GBM data obtained from The Cancer Genome Atlas (TCGA). MethylMix identified a set of driver genes that met criteria for being both differential and functional. Differential refers to a difference in cancer methylation compared to normal tissue; functional refers to having a significant correlation with matched gene expression changes. We then used these MethylMix driver genes to build multivariate models of overall survival using linear regression and validated these models in independent data sets. Applying MethylMix and linear regression we identified a novel methylation signature predictive of overall survival, which we here define as the GLIOMETH signature. Interestingly, GLIOMETH did not include MGMT, suggesting that MGMT methylation is not essential to predict prognosis in GBM. GLIOMETH was prognostically significant even in a multivariate analysis with known prognostic covariates, including MGMT methylation. We validated GLIOMETH in two external DNA methylation data sets and two gene expression data sets, using a leveraging technique predicting methylation in terms of gene expression, showing also a significant survival correlation. Differential and functional DNA methylation is predictive of overall survival in GBM independent of known prognostic factors. We identified GLIOMETH as a DNA methylation signature that is predictive of overall survival in GBM, outperforming MGMT methylation. The GLIOMETH model validated across multiple independent DNA methylation and gene expression validation data sets demonstrating its robustness as an independent predictor of prognosis in GBM. Recent next-generation genomic studies of medulloblastoma have revealed an unexpected and overwhelming convergence of somatic alterations affecting chromatin-modifying genes. Estimates informed by next-generation sequencing implicate that at least one third of all medulloblastomas have somatic mutations in a chromatin modifier, including those targeting histone methyltransfereses, histone demethylases, and related chromatin modulators that collectively function to influence chromatin conformation associated gene expression states. These mutations occur across all four medulloblastoma subgroups although different sets of genes appear to be selectively altered in a subgroup-specific manner. Despite the abundance of evidence implicating deregulation of chromatin modifiers as a key event in medulloblastoma pathogenesis, the medulloblastoma epigenome remains largely unexplored, and studies cataloguing histone modification states on a genome-wide scale have yet to be reported. To comprehensively investigate the histone code in medulloblastoma and the consequences associated with mutations affecting histone-modifying genes, we have performed ChIP-sequencing on a set of well-characterized primary medulloblastoma specimens. Histone marks examined in this study include the six modifications mandated by the International Human Epigenome Consortium (IHEC), including H3K4me3, H3K9me3, H3K27me3, H3K27ac, H3K4me1 and H3K36me3. Chromatin isolates from primary fresh-frozen tissues representative of each medulloblastoma subgroup were immunoprecipitated with the indicated antibodies and sequenced with a HiSeq Illumina sequencer to obtain at least 10 million unique reads per ChIP experiment. Peak calling was performed using multiple publicly available tools and data integrated with existing ENCODE data for the same histone marks. Inter-subgroup comparisons of histone modification states revealed a wealth of distinguishing genomic regions that were highly correlated with alternative patterns of gene expression existing between the subgroups. Moreover, integration with existing mutational profiles demonstrated aberrant chromatin states that could be linked to underlying mutations in select chromatin modifiers. Ongoing work will focus on expanding the cohort and integration with all levels of ‘omic data.

Published
2013

34. Loss of HER2 and decreased T-DM1 efficacy in HER2 positive advanced breast cancer treated with dual HER2 blockade: the SePHER Study

Author

Bon, Giulia, Pizzuti, Laura, Laquintana, Valentina, Loria, Rossella, Porru, Manuela, Marchiò, Caterina, Krasniqi, Eriseld, Barba, Maddalena, Maugeri-Saccà, Marcello, Gamucci, Teresa, Berardi, Rossana, Livi, Lorenzo, Ficorella, Corrado, Natoli, Clara, Cortesi, Enrico, Generali, Daniele, La Verde, Nicla, Cassano, Alessandra, Bria, Emilio, Moscetti, Luca, Michelotti, Andrea, Adamo, Vincenzo, Zamagni, Claudio, Tonini, Giuseppe, Barchiesi, Giacomo, Mazzotta, Marco, Marinelli, Daniele, Tomao, Silverio, Marchetti, Paolo, Valerio, Maria Rosaria, Mirabelli, Rosanna, Russo, Antonio, Fabbri, Maria Agnese, D’Ostilio, Nicola, Veltri, Enzo, Corsi, Domenico, Garrone, Ornella, Paris, Ida, Sarobba, Giuseppina, Giotta, Francesco, Garufi, Carlo, Cazzaniga, Marina, Del Medico, Pietro, Roselli, Mario, Sanguineti, Giuseppe, Sperduti, Isabella, Sapino, Anna, De Maria, Ruggero, Leonetti, Carlo, Di Leo, Angelo, Ciliberto, Gennaro, Falcioni, Rita, and Vici, Patrizia

Published
2020
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35. Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection

Author

Fredolini, Claudia, Pathak, Khyatiben V., Paris, Luisa, Chapple, Kristina M., Tsantilas, Kristine A., Rosenow, Matthew, Tegeler, Tony J., Garcia-Mansfield, Krystine, Tamburro, Davide, Zhou, Weidong, Russo, Paul, Massarut, Samuele, Facchiano, Francesco, Belluco, Claudio, De Maria, Ruggero, Garaci, Enrico, Liotta, Lance, Petricoin, Emanuel F., and Pirrotte, Patrick

Published
2020
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37. A moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave?

Author

Silvestris, Nicola, Apolone, Giovanni, Botti, Gerardo, Ciliberto, Gennaro, Costantini, Massimo, De Paoli, Paolo, Franceschi, Silvia, Opocher, Giuseppe, Paradiso, Angelo, Pronzato, Paolo, Sgambato, Alessandro, and De Maria, Ruggero

Published
2020
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38. A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

Author

Francescangeli, Federica, Contavalli, Paola, De Angelis, Maria Laura, Careccia, Silvia, Signore, Michele, Haas, Tobias Longin, Salaris, Federico, Baiocchi, Marta, Boe, Alessandra, Giuliani, Alessandro, Tcheremenskaia, Olga, Pagliuca, Alfredo, Guardiola, Ombretta, Minchiotti, Gabriella, Colace, Lidia, Ciardi, Antonio, D’Andrea, Vito, La Torre, Filippo, Medema, JanPaul, De Maria, Ruggero, and Zeuner, Ann

Published
2020
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43. Supplementary Figure 1 from Dual Promoter Usage as Regulatory Mechanism of let-7c Expression in Leukemic and Solid Tumors

Author

Pelosi, Andrea, primary, Careccia, Silvia, primary, Sagrestani, Giulia, primary, Nanni, Simona, primary, Manni, Isabella, primary, Schinzari, Valeria, primary, Martens, Joost H.A., primary, Farsetti, Antonella, primary, Stunnenberg, Hendrik G., primary, Gentileschi, Maria Pia, primary, Del Bufalo, Donatella, primary, De Maria, Ruggero, primary, Piaggio, Giulia, primary, and Rizzo, Maria Giulia, primary

Published
2023
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50. Supplementary Figure Legends from Dual Promoter Usage as Regulatory Mechanism of let-7c Expression in Leukemic and Solid Tumors

Author

Pelosi, Andrea, primary, Careccia, Silvia, primary, Sagrestani, Giulia, primary, Nanni, Simona, primary, Manni, Isabella, primary, Schinzari, Valeria, primary, Martens, Joost H.A., primary, Farsetti, Antonella, primary, Stunnenberg, Hendrik G., primary, Gentileschi, Maria Pia, primary, Del Bufalo, Donatella, primary, De Maria, Ruggero, primary, Piaggio, Giulia, primary, and Rizzo, Maria Giulia, primary

Published
2023
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