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38 results on '"Maria, Mittelbrunn"'

1. Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy

Author

Andrés Pastor‐Fernández, Manuel Montero Gómez de las Heras, Jose Ignacio Escrig‐Larena, Marta Barradas, Cristina Pantoja, Adrian Plaza, Jose Luis Lopez‐Aceituno, Esther Durán, Alejo Efeyan, Maria Mittelbrunn, Lola Martinez, and Pablo Jose Fernandez‐Marcos

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2024
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2. Biological properties of extracellular vesicles and their physiological functions

Author

María Yáñez-Mó, Pia R.-M. Siljander, Zoraida Andreu, Apolonija Bedina Zavec, Francesc E. Borràs, Edit I. Buzas, Krisztina Buzas, Enriqueta Casal, Francesco Cappello, Joana Carvalho, Eva Colás, Anabela Cordeiro-da Silva, Stefano Fais, Juan M. Falcon-Perez, Irene M. Ghobrial, Bernd Giebel, Mario Gimona, Michael Graner, Ihsan Gursel, Mayda Gursel, Niels H. H. Heegaard, An Hendrix, Peter Kierulf, Katsutoshi Kokubun, Maja Kosanovic, Veronika Kralj-Iglic, Eva-Maria Krämer-Albers, Saara Laitinen, Cecilia Lässer, Thomas Lener, Erzsébet Ligeti, Aija Linē, Georg Lipps, Alicia Llorente, Jan Lötvall, Mateja Manček-Keber, Antonio Marcilla, Maria Mittelbrunn, Irina Nazarenko, Esther N.M. Nolte-‘t Hoen, Tuula A. Nyman, Lorraine O'Driscoll, Mireia Olivan, Carla Oliveira, Éva Pállinger, Hernando A. del Portillo, Jaume Reventós, Marina Rigau, Eva Rohde, Marei Sammar, Francisco Sánchez-Madrid, N. Santarém, Katharina Schallmoser, Marie Stampe Ostenfeld, Willem Stoorvogel, Roman Stukelj, Susanne G. Van der Grein, M. Helena Vasconcelos, Marca H. M. Wauben, and Olivier De Wever

Subjects
extracellular vesicle, microvesicle, microparticle, exosome, physiology, prokaryote, eukaryote, Cytology, QH573-671
Abstract

In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.

Published
2015
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3. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper

Author

Bogdan Mateescu, Emma J. K. Kowal, Bas W. M. van Balkom, Sabine Bartel, Suvendra N. Bhattacharyya, Edit I. Buzás, Amy H. Buck, Paola de Candia, Franklin W. N. Chow, Saumya Das, Tom A. P. Driedonks, Lola Fernández-Messina, Franziska Haderk, Andrew F. Hill, Jennifer C. Jones, Kendall R. Van Keuren-Jensen, Charles P. Lai, Cecilia Lässer, Italia di Liegro, Taral R. Lunavat, Magdalena J. Lorenowicz, Sybren L. N. Maas, Imre Mäger, Maria Mittelbrunn, Stefan Momma, Kamalika Mukherjee, Muhammad Nawaz, D. Michiel Pegtel, Michael W. Pfaffl, Raymond M. Schiffelers, Hidetoshi Tahara, Clotilde Théry, Juan Pablo Tosar, Marca H. M. Wauben, Kenneth W. Witwer, and Esther N. M. Nolte-‘t Hoen

Subjects
Extracellular vesicles, exosomes, non-coding RNA, mRNA, function, sorting, RNA binding proteins, quantification, Cytology, QH573-671
Abstract

The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has been demonstrated in a multitude of different in vitro cell systems and in a variety of body fluids. RNA-containing EV are in the limelight for their capacity to communicate genetically encoded messages to other cells, their suitability as candidate biomarkers for diseases, and their use as therapeutic agents. Although EV-RNA has attracted enormous interest from basic researchers, clinicians, and industry, we currently have limited knowledge on which mechanisms drive and regulate RNA incorporation into EV and on how RNA-encoded messages affect signalling processes in EV-targeted cells. Moreover, EV-RNA research faces various technical challenges, such as standardisation of EV isolation methods, optimisation of methodologies to isolate and characterise minute quantities of RNA found in EV, and development of approaches to demonstrate functional transfer of EV-RNA in vivo. These topics were discussed at the 2015 EV-RNA workshop of the International Society for Extracellular Vesicles. This position paper was written by the participants of the workshop not only to give an overview of the current state of knowledge in the field, but also to clarify that our incomplete knowledge – of the nature of EV(-RNA)s and of how to effectively and reliably study them – currently prohibits the implementation of gold standards in EV-RNA research. In addition, this paper creates awareness of possibilities and limitations of currently used strategies to investigate EV-RNA and calls for caution in interpretation of the obtained data.

Published
2017
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5. IP-10

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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6. Interleukin-7

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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7. IFN-β2

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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8. Interferon-Gamma

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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9. Insulin-Like Growth Factor Receptor Type I (IGF1R)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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10. Insulin-like Growth Factor Receptor Type I (IGF1R) Signaling and Inflammation

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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11. Icmt (Isoprenylcysteine Carboxyl Methyltransferase)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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12. Integrin Alpha 4

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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13. IP3 Receptor–Associated cGMP Kinase Substrate A

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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14. Intersectin

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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15. Inositol Polyphosphate-5-Phosphatase, 145 kDa

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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16. Interleukin-1 Signal Transducer

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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17. Integrin Alpha 11

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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18. Ionotropic Glutamate Receptors (AMPA, Kainate and NMDA Receptors)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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19. int-2

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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20. Interferon Regulatory Factor 5, IRF5

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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21. Inositol Trisphosphate 5/6-Kinase

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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22. Inositol 1,4,5-trisphosphate-associated cGMP kinase substrate

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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23. Inositol 3,4,5,6-Tetrakisphosphate 1-Kinase

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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24. Integrin-Associated Protein

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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25. ITPK1 (Inositol 1,3,4-Triphosphate 5/6 Kinase)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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26. IkB-zeta

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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27. Integrin Alpha 4 (Itga 4)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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28. IFN-γ

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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29. Inhibitor of DNA Binding 4 (ID4)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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30. IL-1 Inducible Nuclear Ankyrin-Repeat Protein (INAP)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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31. Immunity-Related GTPases (IRG)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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32. Inhibitor of Apoptosis (IAP) Proteins

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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33. Integrin-Associated Signal Transducer

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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34. Integrin Alpha V (ITGAV)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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35. Integrin α2 (ITGA2)

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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36. Immune IFN

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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37. IP3 Receptors

Author

Kathryn M. Appleton, Ian Cushman, Yuri K. Peterson, Balachandran Manavalan, Shaherin Basith, Sangdun Choi, Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto, Benedict Seddon, Maria Traver, Gregory A. Taylor, Mads Gyrd-Hansen, Giovanni Blandino, Giulia Fontemaggi, Michael A. Grillo, Peter Koulen, Alexander Annenkov, Cédric Zeltz, Donald Gullberg, Maria Mittelbrunn, Francisco Sánchez-Madrid, Bethany A. Kerr, Tatiana V. Byzova, Jyrki Heino, Fan-ching Lin, Howard A. Young, Colin W. Taylor, Betsy J. Barnes, Yixing Zhou, Tobias M. H. Schenk, Stephen B. Shears, Ameet S. Sengar, Michael W. Salter, and Sean E. Egan

Published
2012
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38. Basal shuttle of NF-kappaB/I kappaB alpha in resting T lymphocytes regulates HIV-1 LTR dependent expression

Author

Mayte, Coiras, María Rosa, López-Huertas, Joaquín, Rullas, Maria, Mittelbrunn, and José, Alcamí

Subjects
CD4-Positive T-Lymphocytes, Cell Nucleus, Gene Expression Regulation, Viral, Research, NF-kappa B, HIV Infections, Transfection, Virus Replication, Cytosol, DNA, Viral, HIV-1, Humans, I-kappa B Proteins, Cells, Cultured, HIV Long Terminal Repeat, Signal Transduction
Abstract

In HIV-infected T lymphocytes, NF-kappaB/Rel transcription factors are major elements involved in the activation of LTR-dependent transcription from latency. Most NF-kappaB heterodimer p65/p50 is sequestered as an inactive form in the cytoplasm of resting T lymphocytes via its interaction with I kappaB inhibitors. In these cells, both absolute HIV latency and low level ongoing HIV replication have been described. These situations could be related to differences in the balance between NF-kappaB and I kappaB alpha ratio. Actually, control of I kappaB alpha by cellular factors such as Murr-1 plays a critical role in maintaining HIV latency in unstimulated T lymphocytes. Formerly, our group demonstrated the presence of nuclear I kappaB alpha in T cells after PMA activation. Now we attempt to determine the dynamics of NF-kappaB/I kappaB alpha nucleocytosolic transport in absence of activation as a mechanism to explain both the maintenance of latency and the existence of low level ongoing HIV replication in resting CD4+ T lymphocytes.We show that the inhibition of the nuclear export by leptomycin B in resting CD4+ T cells resulted in nuclear accumulation of both I kappaB alpha and p65/RelA, as well as formation of NF-kappaB/I kappaB alpha complexes. This proves the existence of a rapid shuttling of I kappaB alpha between nucleus and cytosol even in absence of cellular activation. The nuclear accumulation of I kappaB alpha in resting CD4+ T lymphocytes results in inhibition of HIV-LTR dependent transcription as well as restrains HIV replication in CD4+ T lymphocytes. On the other hand, basal NF-kappaB activity detected in resting CD4+ T lymphocytes was related to low level HIV replication in these cells.

Published
2007

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